FPIA: A webserver for Fusion Profiling Interactive Analysis

In FPIA we provide the overview and summary of data statistic, which might help gain insights into gene fusion from general level. The number of fusion genes in each cancer varies greatly in different cancers, generally proportional to that of samples size, which suggests that as the sample size grows, an increasing number of fusion gene, and an even better understanding would be expected.

In each cancer, the number of fusion gene identified in across patients were plotted.

Fusion Event Number Across Cancers.(Box plot)

According to the annotations of fusion breakpoints across different regions of the genome, fusion events occurs mostly in the exons, indicating a high probability of truncated and chimeric protein.

Overview of Fusion Gene Breakpoint Across Genomic Regions.(Bar plot)

According to the frequency distribution across different cancers, the majority of the fusions were singletons, with a series of lineage specific-fusions identified, e.g., TMPRSS2--ERG fusion in PRAD (129 individuals) and CCDC6--RET fusion in THCA (20 individuals).

Frequency of Recurrent Fusions in Each Cancer Type.(Dot plot)

ACC FGFR3--TACC3 (17) BLCA ESR1--C6orf97 (14) BRCA FGFR3--TACC3 (10) CESC FGFR2--BICC1 (4) C10orf68--CCDC7 (14) COAD VAV2--FNBP1 (2) FGFR3--TACC3 (4) ESCA EGFR--SEPT14 (14) GBM FHOD3--MOCOS (5) HNSC VPS13C--RB1CC1 (2) KICH SFPQ--TFE3 (10) KIRC PRCC--TFE3 (6) PML--RARA (31) FGFR3--TACC3 (4) DNAJB1--PRKACA (7)