1. Prognostic gene signatures and therauptic agent for biliary atresia

We identified a 14-gene prognostic signature at diagnosis that predicts two year, transplant-free survival in children with biliary atresia – the most common and leading indication for pediatric liver transplant. In addition, we found that the antioxidant N-acetly-cysteine (NAC) as a potential therauptic agent to prevent biliary injury and fibrosis. [Link].

2. Shared connectome among human cholangiopathies

We uncovered a shared connectome among the three main human cholangiopatheis (biliary atresia, primary biliary cholangitis and primary sclerosing cholangitis). [Link].