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Dengue virus is dengue fever's noxa. Being one of the most dangerous viral mosquito-borne infectious diseases, dengue fever has caused severe health burden in Asia's tropical and subtropical regions. Probing into dengue virus' evolutionary history and variation in SoutheastAsian with Biostatistics and Bioinformatics method could make a difference in the study of dengue virus' transmission mode.

In this article, 321 genome and 1463 E gene sequences of dengue virus type 1,2,3,4 in Southeast Asia mainly ranging from 1974 to 2014 were calculated about identity comparison, codon bias, phylogenetic analysis, selection pressure and protein's secondary structure prediction. Thisstudy carried out the comparison about evolutionary history and variation of dengue virustype1,2,3,4 in Southeast Asian using the method of comparative genomics and evolutionary biology.

The amino acid and nucleotide's identity in the same Asia country are higher than the others while the amino acids' identity of denv-1 type virus and the nucleotide's identity of denv-2 type virus were slightly lower. On the contrast, the amino acids and nucleotide's identities of denv-3 type virus were the highest. Both identities compared between denv-1 and denv-2 was more similar than the ones of denv-1 and denv-3 virus. Some partial nucleotide substitutions or frame shift mutation usually happened in denv-1 virus's evolution and the mutations of other type virus usually happened in noncoding region.

The overall codon biases of denv-1,2,3,4 virusesin Southeast Asian were inconspicuous and had constant time-variation. The primary epidemic areas of four serotypes viruseswere similar, and the transmissions had largely increased in recent 15 years. The situation about non synonymous substitutions of Denv-3 type virus was quite distinct and envelope, the mutations accumulation of NS5 proteins might also be one of the fever outbreak's necessary conditions.

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