:root{--ink:#153340;--muted:#627681;--teal:#0f766e;--teal-dark:#075e59;--border:#dbe5e8;--surface:#fff;--background:#f5f8fa;--el-color-primary:#0f766e;--el-border-radius-base:7px;font-family:DM Sans,-apple-system,BlinkMacSystemFont,Segoe UI,sans-serif;color:var(--ink);background:var(--background);font-size:15px;line-height:1.6;font-synthesis:none}*{box-sizing:border-box}body{margin:0}a{color:var(--teal);text-decoration:none}a:hover{color:var(--teal-dark);text-decoration:underline}button,input,select{font:inherit}a,button,input,select{touch-action:manipulation}button{cursor:pointer}button:disabled{opacity:.6;cursor:wait}a:focus-visible,button:focus-visible,input:focus-visible,select:focus-visible{outline:3px solid #e8a63a;outline-offset:3px}h1,h2,h3,h4{font-family:Manrope,-apple-system,BlinkMacSystemFont,Segoe UI,sans-serif;line-height:1.25;letter-spacing:-.035em;margin:0 0 16px;font-weight:800}h1{font-size:42px}h2{font-size:26px}h3{font-size:20px}p{margin:0 0 16px}small{font-size:12px}hr{border:0;border-top:1px solid var(--border);margin:25px 0}input,select{background:#fff;color:var(--ink);border:1px solid #bfced3;border-radius:7px;min-height:44px;padding:10px 12px;max-width:100%;min-width:0}input::-moz-placeholder{color:#6b7e87}input::placeholder{color:#6b7e87}input[type=checkbox]{min-height:auto;width:17px;height:17px;accent-color:var(--teal)}label{font-weight:600;font-size:13px}select{padding-right:26px}.container{width:min(1280px,calc(100% - 64px));margin:auto}.page{padding-top:38px;padding-bottom:80px;min-height:65vh}.narrow{max-width:940px}.section{padding:24px 0 40px}.section.compact{padding:32px 0 12px}.results-heading,.section-heading{display:flex;gap:24px;align-items:center;justify-content:space-between;margin-bottom:22px}.results-heading h2,.section-heading h2{margin-bottom:4px}.section-heading p{margin:8px 0 0;color:var(--muted)}.eyebrow{text-transform:uppercase;letter-spacing:.14em;color:var(--teal);font-weight:700;font-size:11px;margin-bottom:16px}.muted{color:var(--muted)}.small-text{font-size:12px}.sr-only{position:absolute;width:1px;height:1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap}.skip-link{position:fixed;z-index:100;top:-80px;left:20px;padding:12px 20px;background:var(--teal);color:#fff}.skip-link:focus{top:12px}.button{display:inline-flex;align-items:center;justify-content:center;gap:12px;border:1px solid var(--teal);background:var(--teal);border-radius:7px;padding:11px 20px;min-height:44px;font-size:13px;line-height:1.5;font-weight:700;white-space:nowrap;transition:background .15s}.button,.button:hover{color:#fff;text-decoration:none}.button:hover{background:var(--teal-dark)}.button.secondary{background:#fff;color:var(--teal);border-color:#b6cecb}.button.secondary:hover{background:#edf7f5}.button.small{padding:6px 14px;min-height:34px;font-size:12px}.full-width{width:100%;margin-top:10px}.text-link{font-size:13px;font-weight:700}.grow{flex:1;min-width:220px}.field{display:flex;flex-direction:column;gap:7px;min-width:140px}.site-header{background:#fff;position:relative;z-index:20;border-bottom:1px solid #edf2f4}.nav-inner{max-width:1390px;margin:auto;padding:0 32px;min-height:83px;justify-content:space-between;gap:32px}.brand,.nav-inner{display:flex;align-items:center}.brand{gap:11px;color:var(--ink);font-size:24px;font-family:Manrope,sans-serif;font-weight:800;letter-spacing:-1px}.brand:hover{text-decoration:none}.brand-icon{display:grid;place-items:center;background:var(--teal);color:#fff;width:36px;height:38px;border-radius:12px 4px 12px 4px;font-size:24px}.brand-accent{color:var(--teal)}.site-header nav{display:flex;gap:29px;align-items:center}.site-header nav a{font-size:13px;font-weight:700;color:#526974;position:relative;padding:29px 0}.site-header nav .router-link-active,.site-header nav a:hover{color:var(--teal);text-decoration:none}.site-header nav .router-link-active:after{content:"";position:absolute;height:3px;background:var(--teal);bottom:0;left:0;right:0;border-radius:4px}.menu-toggle{display:none}.release-bar{background:#eef5f4;border-bottom:1px solid #e0e9e7;font-size:11px;color:#5e7976}.release-bar .container{display:flex;justify-content:space-between;gap:15px;padding:9px 0}.release-bar strong{font-weight:600}.site-footer{padding:45px 0 25px;background:#eaf0f3;border-top:1px solid #dde6eb;color:#647783;font-size:12px}.footer-content{display:flex;justify-content:space-between;gap:30px}.footer-content strong{font-family:Manrope,sans-serif;font-size:21px;color:var(--ink)}.footer-content p{margin-top:8px}.footer-content a{font-weight:600}.footer-note{padding-top:20px;border-top:1px solid #d5e1e6;margin-top:15px;font-size:11px}.hero{background:linear-gradient(110deg,#f4faf8,#f7fafb 68%,#edf5f6);border-bottom:1px solid var(--border);padding:65px 0}.hero-grid{display:grid;grid-template-columns:1.7fr 1fr;gap:50px;align-items:center}.hero h1{font-size:56px;line-height:1.12;letter-spacing:-2.5px}.hero h1 span{color:var(--teal)}.hero-description{font-size:17px;line-height:1.75;color:#5d737e;max-width:650px;margin:23px 0 30px}.hero-search{display:flex;background:#fff;border:1px solid #c7d9d7;border-radius:10px;padding:7px;gap:5px;box-shadow:0 8px 28px #173c3710}.hero-search input{flex:1;border:none;padding-left:12px;min-width:130px;font-size:13px}.hero-search select{border:none;border-left:1px solid #dce7e6;border-radius:0;min-width:90px;font-size:13px}.hero-links{display:flex;align-items:center;gap:26px;margin-top:24px;font-size:13px;font-weight:700}.hero-illustration{text-align:center;max-width:390px;justify-self:center;width:100%}.hero-illustration svg{width:100%;filter:drop-shadow(0 18px 26px #0f766e0b)}.illustration-label{color:#7a9995;font-size:11px;letter-spacing:.06em}.stats-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:18px}.stat-card{padding:24px;background:#fff;border:1px solid var(--border);border-radius:10px;display:flex;flex-direction:column;box-shadow:0 3px 12px #1d435204}.stat-card span{color:#526d77;font-size:12px;font-weight:700}.stat-card strong{font-family:Manrope,sans-serif;font-size:32px;line-height:1.7;letter-spacing:-1px;color:var(--ink)}.stat-card small{color:#71838b;font-size:11px}.feature-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:22px}.feature-card{display:block;border:1px solid var(--border);border-radius:10px;padding:30px;background:#fff;color:var(--ink);transition:border-color .15s,transform .15s}.feature-card:hover{border-color:#76b4aa;text-decoration:none;transform:translateY(-3px);color:var(--ink)}.feature-card p{font-size:14px;color:#667b86;line-height:1.8;margin:0 0 26px}.feature-card h3{margin-top:22px}.feature-number{display:inline-flex;justify-content:center;align-items:center;width:38px;height:38px;border-radius:10px;background:#e5f2ef;color:var(--teal);font-weight:700;font-size:13px}.scope-panel{display:grid;grid-template-columns:1fr 1fr;gap:45px;border-top:1px solid var(--border);padding-top:45px}.scope-panel h2{font-size:26px}.scope-panel>p{color:var(--muted);font-size:14px;line-height:1.9;padding-top:20px}.page-heading{max-width:920px;margin-bottom:32px}.page-heading>p:last-child{color:var(--muted);font-size:15px;line-height:1.8;margin:16px 0 0}.detail-title{font-size:33px;line-height:1.35}.back-link{display:inline-block;margin-bottom:25px;font-size:13px}.inline-meta{display:flex;flex-wrap:wrap;gap:15px;align-items:center;font-size:13px;color:var(--muted);margin-top:20px}.filter-panel,.search-panel{padding:24px;background:#fff;border:1px solid var(--border);border-radius:9px;display:flex;flex-wrap:wrap;align-items:flex-end;gap:16px;margin-bottom:30px}.filter-search{display:flex;flex-direction:column;gap:7px;flex:1 0 100%}.filter-panel>.field{flex:1;min-width:180px;max-width:350px}.search-panel.compact{margin:20px 0}.count-pill{display:inline-block;background:#e5efed;color:var(--teal);padding:4px 10px;vertical-align:middle;border-radius:15px;font-family:DM Sans,sans-serif;font-size:12px;letter-spacing:0;margin-left:7px}.study-list{display:grid;gap:16px}.study-card{padding:25px 28px;border:1px solid var(--border);background:#fff;border-radius:9px}.study-card-top{display:flex;justify-content:space-between;gap:14px;align-items:center;margin-bottom:14px}.accession{font-size:12px;font-weight:700;letter-spacing:.03em;color:var(--teal)}.study-card h3{font-size:19px;letter-spacing:-.02em;max-width:1040px}.study-card h3 a{color:var(--ink)}.study-tags{display:flex;flex-wrap:wrap;gap:8px;margin:10px 0 17px}.study-tags>span{background:#eef3f5;color:#5f7884;font-size:11px;padding:3px 9px;border-radius:4px}.study-summary{color:var(--muted);font-size:13px;display:-webkit-box;-webkit-line-clamp:3;-webkit-box-orient:vertical;overflow:hidden}.status-badge{display:inline-flex;align-items:center;gap:5px;border-radius:5px;padding:4px 8px;background:#edf1f4;font-size:10px;font-weight:700;line-height:1.5;color:#5c707e;white-space:normal;max-width:260px}.status-badge.positive{background:#e4f3eb;color:#216d4d}.status-badge.warning{background:#fff1d8;color:#86601d}.status-badge.negative{background:#fbe8e7;color:#9b4743}.table-scroll{overflow:auto;border:1px solid var(--border);border-radius:9px;background:#fff}.data-table{border-collapse:collapse;width:100%;font-size:12px;line-height:1.6}.data-table th{text-align:left;font-size:11px;font-weight:700;color:#5c7680;background:#eef4f5;padding:14px 17px;white-space:nowrap;border-bottom:1px solid var(--border)}.data-table td{padding:15px 17px;border-bottom:1px solid #e9eef0;vertical-align:top;max-width:420px;min-width:100px;overflow-wrap:anywhere}.data-table tr:last-child td{border-bottom:0}.data-table td small{display:block;color:#71858e;font-size:10px;margin-top:5px}.data-table td>a{font-weight:600}.data-table tr:hover{background:#fcfefe}.empty-cell{text-align:center!important;padding:35px!important;color:var(--muted)}.data-pager{justify-content:space-between;gap:16px;margin-top:22px;font-size:12px;flex-wrap:wrap}.data-pager,.resource-state{display:flex;align-items:center;color:var(--muted)}.resource-state{min-height:150px;padding:40px 24px;background:#fff;border:1px solid var(--border);border-radius:9px;justify-content:center;gap:14px;font-size:14px}.error-state{flex-direction:column;background:#fffaf3;border-color:#eadbbf;align-items:flex-start;color:#795e31;min-height:110px}.error-state p{margin-bottom:0}.spinner{height:20px;width:20px;border:2px solid #cee3de;border-top-color:var(--teal);border-radius:50%;animation:spin 1s linear infinite}@keyframes spin{to{transform:rotate(1turn)}}.empty-panel{padding:55px 35px;background:#fff;border:1px solid var(--border);border-radius:9px;color:var(--muted)}.empty-panel h1,.empty-panel h2,.empty-panel h3{color:var(--ink)}.notice{padding:16px 20px;border-left:3px solid #78aca3;background:#eaf4f1;color:#4f716b;font-size:13px;line-height:1.8;border-radius:0 6px 6px 0;margin:24px 0}.metadata-grid{display:grid;grid-template-columns:repeat(4,1fr);background:#fff;border:1px solid var(--border);border-radius:9px;margin:28px 0}.metadata-grid>div{padding:21px 24px;border-right:1px solid var(--border);overflow-wrap:anywhere}.metadata-grid>div:last-child{border-right:none}.metadata-grid label{display:block;color:var(--muted);font-size:11px;margin-bottom:8px}.metadata-grid strong{font-size:13px}.object-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:20px}.object-card{display:block;padding:26px;border:1px solid var(--border);border-radius:9px;background:#fff;color:var(--ink);overflow-wrap:anywhere}.object-card:hover{border-color:#77b3aa;text-decoration:none;color:var(--ink)}.object-card h3{font-size:18px;margin:20px 0 14px}.object-card p{font-size:13px;color:var(--muted)}.object-card .study-card-top{flex-wrap:wrap}.gene-candidates{margin:25px 0}.gene-chip{display:inline-flex;flex-direction:column;align-items:flex-start;gap:6px;background:#fff;border:1px solid var(--border);border-radius:7px;padding:15px 20px;margin:0 10px 10px 0;color:var(--ink)}.gene-chip small{color:var(--muted)}.gene-chip.selected{border-color:var(--teal);background:#edf7f4}.inline-control{gap:10px;color:var(--muted);font-size:12px}.inline-control,.inline-search{display:flex;align-items:center}.inline-search{gap:8px}.inline-search input{min-height:35px;padding:7px 12px;font-size:12px}.chart-panel{background:#fff;border:1px solid var(--border);border-radius:9px;width:100%;min-width:0}.chart-caption{font-size:11px;color:var(--muted);line-height:1.8;margin:12px 0 0}.chart-heading{display:flex;align-items:center;justify-content:space-between;gap:12px;margin-bottom:14px}.chart-heading h2{margin:0}.chart-heading span{font-size:11px}.explorer-layout{display:grid;grid-template-columns:255px minmax(0,1fr);gap:26px;align-items:start}.explorer-controls{background:#fff;padding:23px;border:1px solid var(--border);border-radius:9px}.explorer-controls h2{font-size:19px}.explorer-controls .field{margin-top:16px;min-width:0}.explorer-controls .small-text{margin:20px 0 0}.explorer-main{min-width:0}.composition-section{margin:32px 0}.composition-section .table-scroll{max-height:430px}.composition-section .section-heading{align-items:flex-start}.composition-section .section-heading p{font-size:12px}.composition-section select{max-width:210px;font-size:12px}.inline-error{font-size:12px;line-height:1.7;color:#a0403d;background:#fff1ef;padding:12px;border-radius:6px;margin:15px 0}.methods-nav{display:flex;gap:20px;flex-wrap:wrap;border-top:1px solid var(--border);border-bottom:1px solid var(--border);padding:18px 0;font-size:13px;margin:30px 0}.prose-section{padding:25px 0 15px;scroll-margin-top:20px}.prose-section p{font-size:14px;line-height:1.95;color:#576e7b}.prose-section h2{font-size:24px}.el-pagination{flex-wrap:wrap;gap:6px}.el-pagination .el-select{width:115px}.el-pagination.is-background .el-pager li.is-active{background-color:var(--teal)}@media(min-width:1600px){.container{max-width:1390px}.hero h1{font-size:64px}.hero{padding:85px 0}.hero-grid{grid-template-columns:1.7fr 1fr}.hero-illustration{max-width:440px}}@media(max-width:1100px){.hero-grid{grid-template-columns:1fr .65fr;gap:15px}.hero h1{font-size:47px}.hero-search{flex-wrap:wrap}.hero-search input{min-width:200px}.hero-search .button{flex:1}.hero-illustration{max-width:310px}.site-header nav{gap:18px}.brand{font-size:21px}.feature-card{padding:24px}.metadata-grid,.object-grid{grid-template-columns:repeat(2,1fr)}.metadata-grid>div:nth-child(2){border-right:none}.metadata-grid>div:nth-child(-n+2){border-bottom:1px solid var(--border)}}@media(max-width:800px){.container{width:calc(100% - 36px)}.nav-inner{padding:0 18px;min-height:70px;flex-wrap:wrap;gap:0}.menu-toggle{display:block;background:#fff;border:1px solid var(--border);border-radius:5px;padding:7px 12px;color:var(--teal);font-size:12px}.site-header nav{display:none;flex-basis:100%;flex-direction:column;gap:0;align-items:stretch;padding:10px 0}.site-header nav.is-open{display:flex}.site-header nav a{padding:12px}.site-header nav .router-link-active:after{display:none}.release-bar .container{flex-direction:column;gap:2px;font-size:10px}.hero{padding:40px 0}.hero-grid{grid-template-columns:1fr}.hero h1{font-size:45px;letter-spacing:-1.8px}.hero-illustration{display:none}.hero-description{font-size:15px;max-width:620px}.hero-search .button{flex:0 0 auto}.stats-grid{grid-template-columns:repeat(2,1fr);gap:12px}.stat-card{padding:19px}.stat-card strong{font-size:29px}.feature-grid{grid-template-columns:1fr}.feature-card{padding:25px}.feature-card h3{margin-top:15px}.feature-card p{margin-bottom:16px}.scope-panel{grid-template-columns:1fr;gap:5px}.scope-panel>p{padding-top:0}.footer-content{flex-direction:column;gap:10px}.page{padding-top:28px}.page-heading h1{font-size:33px}.page-heading .detail-title{font-size:27px}.results-heading,.section-heading{align-items:flex-start;flex-direction:column;gap:12px}.filter-panel,.search-panel{padding:18px}.filter-panel>.field{min-width:160px}.metadata-grid>div{padding:18px}.explorer-layout{grid-template-columns:1fr}.explorer-controls{display:block}.explorer-controls form:first-of-type{display:grid;grid-template-columns:1fr 1fr;gap:10px}.explorer-controls .full-width{margin-top:0}.explorer-controls .field{margin:0 0 15px}.explorer-controls form:first-of-type .field{margin:0}.explorer-controls hr{margin:20px 0}.object-card{padding:21px}.chart-heading{flex-wrap:wrap}.composition-section .section-heading{flex-direction:column}.data-pager .el-pagination{max-width:100%}.hero-links{gap:16px;font-size:12px}}@media(max-width:480px){.hero-search input{flex-basis:100%}.hero-search .button{flex:1}.hero-links{flex-wrap:wrap}.stat-card strong{font-size:25px}.stat-card small{font-size:10px}.page-heading h1{font-size:30px}.object-grid{grid-template-columns:1fr}.filter-panel>.field{flex-basis:100%;max-width:none}.search-panel>.field{flex-basis:100%;min-width:0}.metadata-grid{grid-template-columns:1fr}.metadata-grid>div{border-right:none;border-bottom:1px solid var(--border)}.metadata-grid>div:last-child{border-bottom:0}.explorer-controls form:first-of-type{grid-template-columns:1fr}.study-card{padding:20px}.study-card-top{align-items:flex-start}.status-badge{max-width:160px}.inline-search,.inline-search input{width:100%}.results-heading>label{font-size:11px}.data-pager .el-pagination .el-pagination__sizes{margin-left:0}.empty-panel{padding:35px 23px}}@media(prefers-reduced-motion:reduce){*{animation:none!important;transition:none!important}}.result-kind-filter{max-width:430px;margin:18px 0}.result-kind-filter+label{margin-bottom:16px}.gene-chip{max-width:100%;overflow-wrap:anywhere;text-align:left}.skip-link{opacity:0;pointer-events:none}.skip-link:focus{opacity:1;pointer-events:auto}.detail-title{overflow-wrap:anywhere}.kg-summary{display:flex;flex-wrap:wrap;gap:12px 26px;color:var(--muted);font-size:12px}.kg-workspace{display:grid;grid-template-columns:250px minmax(0,1fr);gap:24px;align-items:start}.kg-controls .inline-control{margin:18px 0}.kg-entity-card{padding:24px;border:1px solid var(--border);background:#fff;border-radius:9px;margin-bottom:22px;overflow-wrap:anywhere}.kg-entity-card h3{font-size:17px;margin-top:18px}.kg-path-controls{display:flex;flex-wrap:wrap;gap:12px;align-items:center;margin-bottom:24px}.kg-path-controls label{flex-basis:100%}.kg-path-controls select{flex:1;min-width:180px}.kg-text-button{background:transparent;border:0;padding:0;text-align:left;color:var(--teal);font:inherit;overflow-wrap:anywhere}.kg-dialog{width:min(900px,calc(100% - 32px));max-height:88vh;border:1px solid var(--border);border-radius:12px;padding:28px;color:var(--ink);background:var(--background);overflow-wrap:anywhere}.kg-dialog::backdrop{background:#16313db3}.kg-dialog-header{display:flex;justify-content:space-between;gap:20px;align-items:start}.kg-evidence-card{background:#fff;border:1px solid var(--border);padding:22px;border-radius:8px;margin:18px 0}.kg-evidence-card h3{font-size:18px}.kg-evidence-card blockquote{border-left:3px solid var(--teal);padding:8px 16px;margin:16px 0;font-size:14px;white-space:pre-line}.kg-candidates{margin-bottom:25px}.kg-controls .field{min-width:0}.kg-controls select{width:100%}@media(max-width:900px){.kg-workspace{grid-template-columns:1fr}.kg-controls{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:14px}.kg-controls h2{grid-column:1/-1}.kg-controls .field{margin:0}}@media(max-width:480px){.kg-controls{display:block}.kg-controls .field{margin:14px 0}.kg-dialog{padding:18px}.kg-evidence-card{padding:16px}}.chart-toolbar{display:flex;align-items:center;justify-content:space-between;gap:16px;flex-wrap:wrap;margin:18px 0}.chart-toolbar h3{margin:0}.chart-controls{display:flex;align-items:center;gap:10px;flex-wrap:wrap}.chart-data-table{margin-top:16px}.chart-data-details{margin-top:20px;font-size:13px}.chart-data-details>summary{color:var(--teal);cursor:pointer;font-weight:600}.composition-chart-toolbar{margin-top:30px}.catalog-breakdown .inline-control,.composition-chart-toolbar .inline-control{flex-wrap:wrap}.catalog-breakdown .inline-control select{max-width:100%}@media(max-width:600px){.chart-toolbar{align-items:flex-start}.chart-toolbar .inline-control{flex-wrap:wrap}.chart-controls{width:100%;align-items:flex-start}.chart-controls select{max-width:100%}.composition-chart-toolbar .chart-controls{display:grid;grid-template-columns:1fr}.chart-data-table .data-table td,.chart-data-table .data-table th{padding:11px 12px}}