SDHA (Sex Differences in Human Aging) Database—a vital resource for researchers exploring the intricate relationship between sex and aging.
Aging is a complex process marked by the gradual decline of tissue and organ function, leading to age-related diseases and increased mortality. While it is known that aging impacts both females and males, significant differences in their experiences remain largely unexplored.
Our recent study analyzed transcriptome data from 49 healthy human tissues in the GTEx database and two datasets from the GEO database. We identified four key sex-specific aging characteristics: mitochondrial dysfunction, inflammaging, neurodegenerative diseases, and telomere maintenance. Notably, males exhibited more severe mitochondrial dysfunction and inflammation, while females showed greater neurodegeneration and higher expression of genes related to telomere maintenance.
SDHA Database provides researchers with access to these findings, facilitating a deeper understanding of sex differences in aging. By highlighting these disparities, we aim to inspire the development of targeted, sex-specific interventions for aging-related diseases.