ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003779 actin binding 31/304 443/18639 0.0699774266365688 4.29049097065463 9.66943986827111e-12 6.16910263595697e-09 GO:0045296 cadherin binding 24/304 334/18639 0.0718562874251497 4.40568862275449 1.3935767068868e-09 4.44550969496888e-07 GO:0051015 actin filament binding 18/304 209/18639 0.0861244019138756 5.2805023923445 1.04083196642873e-08 2.21350264860511e-06 GO:0030695 GTPase regulator activity 24/304 489/18639 0.049079754601227 3.00920245398773 1.77331860121148e-06 0.000234461872819082 GO:0060589 nucleoside-triphosphatase regulator activity 24/304 490/18639 0.0489795918367347 3.0030612244898 1.83747549231255e-06 0.000234461872819082 GO:0002020 protease binding 11/304 136/18639 0.0808823529411765 4.95909926470588 1.44824617657015e-05 0.00153996843441959 GO:0005543 phospholipid binding 21/304 497/18639 0.0422535211267606 2.59066901408451 7.20715425989611e-05 0.00656880631116246 GO:0005201 extracellular matrix structural constituent 11/304 168/18639 0.0654761904761905 4.01450892857143 0.000101293361616894 0.00772317501956436 GO:0005085 guanyl-nucleotide exchange factor activity 13/304 230/18639 0.0565217391304348 3.46548913043478 0.000108947609993855 0.00772317501956436 GO:1990782 protein tyrosine kinase binding 9/304 117/18639 0.0769230769230769 4.71634615384615 0.000128430351152255 0.00819385640351384 GO:0005518 collagen binding 7/304 72/18639 0.0972222222222222 5.9609375 0.000170445942947014 0.00988586469092679 GO:0051020 GTPase binding 15/304 315/18639 0.0476190476190476 2.91964285714286 0.000220858872446447 0.0117423300517361 GO:0005516 calmodulin binding 11/304 207/18639 0.0531400966183575 3.25815217391304 0.000613743643908216 0.0293139217338281 GO:0045294 alpha-catenin binding 3/304 11/18639 0.272727272727273 16.7215909090909 0.000643252201055789 0.0293139217338281 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/304 44/18639 0.113636363636364 6.96732954545454 0.00072028715703675 0.0306362137459631 GO:0097110 scaffold protein binding 6/304 70/18639 0.0857142857142857 5.25535714285714 0.000978721321700136 0.0390265127027929 GO:0008187 poly-pyrimidine tract binding 4/304 30/18639 0.133333333333333 8.175 0.00136063740457961 0.0485043424770927 GO:0034236 protein kinase A catalytic subunit binding 3/304 14/18639 0.214285714285714 13.1383928571429 0.00136846107302142 0.0485043424770927 GO:0098631 cell adhesion mediator activity 6/304 76/18639 0.0789473684210526 4.84046052631579 0.0015044423147015 0.0505175893041871 GO:0005096 GTPase activator activity 12/304 271/18639 0.044280442804428 2.71494464944649 0.00172075525426016 0.0528726001348124 GO:0070717 poly-purine tract binding 4/304 32/18639 0.125 7.6640625 0.00174032069409257 0.0528726001348124 GO:0046332 SMAD binding 6/304 79/18639 0.0759493670886076 4.65664556962025 0.0018367122156962 0.0532646542551897 GO:0071889 14-3-3 protein binding 4/304 33/18639 0.121212121212121 7.43181818181818 0.00195523222911751 0.0542364418337814 GO:0004721 phosphoprotein phosphatase activity 9/304 175/18639 0.0514285714285714 3.15321428571429 0.00236117934851931 0.062217308197193 GO:0031267 small GTPase binding 12/304 283/18639 0.0424028268551237 2.59982332155477 0.00246335871493225 0.062217308197193 GO:0035091 phosphatidylinositol binding 12/304 284/18639 0.0422535211267606 2.59066901408451 0.00253550158797338 0.062217308197193 GO:0017124 SH3 domain binding 7/304 115/18639 0.0608695652173913 3.7320652173913 0.00280101221700418 0.0661868812758765 GO:0003727 single-stranded RNA binding 6/304 89/18639 0.0674157303370786 4.13342696629213 0.00335470899741616 0.0764394407268397 GO:0004857 enzyme inhibitor activity 15/304 416/18639 0.0360576923076923 2.21078725961538 0.00359908782533158 0.0791799321572947 GO:0005178 integrin binding 8/304 161/18639 0.0496894409937888 3.04658385093168 0.00499455152497236 0.106217462431079 GO:0001091 RNA polymerase II general transcription initiation factor binding 3/304 24/18639 0.125 7.6640625 0.00674630036885281 0.138843214042842 GO:0019838 growth factor binding 7/304 136/18639 0.0514705882352941 3.15579044117647 0.00699963432993517 0.139555209453082 GO:0003725 double-stranded RNA binding 5/304 75/18639 0.0666666666666667 4.0875 0.00760573526553737 0.147035508666683 GO:0008013 beta-catenin binding 6/304 106/18639 0.0566037735849057 3.47051886792453 0.00783574811076369 0.147035508666683 GO:0008143 poly(A) binding 3/304 26/18639 0.115384615384615 7.07451923076923 0.00846107379402 0.154233288016707 GO:0008266 poly(U) RNA binding 3/304 27/18639 0.111111111111111 6.8125 0.00940552606487832 0.166666512786643 GO:0001618 virus receptor activity 5/304 81/18639 0.0617283950617284 3.78472222222222 0.0104382421512519 0.166666512786643 GO:0030971 receptor tyrosine kinase binding 5/304 81/18639 0.0617283950617284 3.78472222222222 0.0104382421512519 0.166666512786643 GO:0001094 TFIID-class transcription factor complex binding 2/304 10/18639 0.2 12.2625 0.0109432509023499 0.166666512786643 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/304 10/18639 0.2 12.2625 0.0109432509023499 0.166666512786643 GO:0008239 dipeptidyl-peptidase activity 2/304 10/18639 0.2 12.2625 0.0109432509023499 0.166666512786643 GO:0140272 exogenous protein binding 5/304 82/18639 0.0609756097560976 3.73856707317073 0.0109717767038229 0.166666512786643 GO:0043236 laminin binding 3/304 29/18639 0.103448275862069 6.3426724137931 0.0114722658439303 0.170216409498315 GO:0098632 cell-cell adhesion mediator activity 4/304 55/18639 0.0727272727272727 4.45909090909091 0.0123269491309903 0.172287857197607 GO:0001968 fibronectin binding 3/304 30/18639 0.1 6.13125 0.0125957801149693 0.172287857197607 GO:0031210 phosphatidylcholine binding 3/304 30/18639 0.1 6.13125 0.0125957801149693 0.172287857197607 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/304 11/18639 0.181818181818182 11.1477272727273 0.0132321395026375 0.172287857197607 GO:0048407 platelet-derived growth factor binding 2/304 11/18639 0.181818181818182 11.1477272727273 0.0132321395026375 0.172287857197607 GO:0097493 structural molecule activity conferring elasticity 2/304 11/18639 0.181818181818182 11.1477272727273 0.0132321395026375 0.172287857197607 GO:0016791 phosphatase activity 10/304 273/18639 0.0366300366300366 2.24587912087912 0.0144985085312151 0.185000968858305 GO:0008603 cAMP-dependent protein kinase regulator activity 2/304 12/18639 0.166666666666667 10.21875 0.0157090983676664 0.192738553049445 GO:0097371 MDM2/MDM4 family protein binding 2/304 12/18639 0.166666666666667 10.21875 0.0157090983676664 0.192738553049445 GO:0015026 coreceptor activity 4/304 61/18639 0.0655737704918033 4.02049180327869 0.0174900655173449 0.202041680499253 GO:0017154 semaphorin receptor activity 2/304 13/18639 0.153846153846154 9.43269230769231 0.0183674254999321 0.202041680499253 GO:0035673 oligopeptide transmembrane transporter activity 2/304 13/18639 0.153846153846154 9.43269230769231 0.0183674254999321 0.202041680499253 GO:0051011 microtubule minus-end binding 2/304 13/18639 0.153846153846154 9.43269230769231 0.0183674254999321 0.202041680499253 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/304 13/18639 0.153846153846154 9.43269230769231 0.0183674254999321 0.202041680499253 GO:0089720 caspase binding 2/304 13/18639 0.153846153846154 9.43269230769231 0.0183674254999321 0.202041680499253 GO:1901682 sulfur compound transmembrane transporter activity 4/304 63/18639 0.0634920634920635 3.89285714285714 0.0194688659000732 0.210527736343165 GO:0005545 1-phosphatidylinositol binding 2/304 14/18639 0.142857142857143 8.75892857142857 0.0212005862377505 0.218160871285239 GO:0015926 glucosidase activity 2/304 14/18639 0.142857142857143 8.75892857142857 0.0212005862377505 0.218160871285239 GO:0044548 S100 protein binding 2/304 14/18639 0.142857142857143 8.75892857142857 0.0212005862377505 0.218160871285239 GO:0004725 protein tyrosine phosphatase activity 5/304 98/18639 0.0510204081632653 3.1281887755102 0.0221750283401968 0.224566160016596 GO:0000146 microfilament motor activity 3/304 38/18639 0.0789473684210526 4.84046052631579 0.0237982001545856 0.227073672508857 GO:0050840 extracellular matrix binding 4/304 67/18639 0.0597014925373134 3.66044776119403 0.0238272609490296 0.227073672508857 GO:0140789 histone phosphatase activity 6/304 136/18639 0.0441176470588235 2.70496323529412 0.0241946835021336 0.227073672508857 GO:0031005 filamin binding 2/304 15/18639 0.133333333333333 8.175 0.0242022096090945 0.227073672508857 GO:0050700 CARD domain binding 2/304 15/18639 0.133333333333333 8.175 0.0242022096090945 0.227073672508857 GO:0050997 quaternary ammonium group binding 3/304 40/18639 0.075 4.5984375 0.0272199256341328 0.242493917727646 GO:0005159 insulin-like growth factor receptor binding 2/304 16/18639 0.125 7.6640625 0.0273660847592328 0.242493917727646 GO:0015562 efflux transmembrane transporter activity 2/304 16/18639 0.125 7.6640625 0.0273660847592328 0.242493917727646 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/304 16/18639 0.125 7.6640625 0.0273660847592328 0.242493917727646 GO:0001727 lipid kinase activity 3/304 41/18639 0.0731707317073171 4.48628048780488 0.0290238677488048 0.250232805726182 GO:0042169 SH2 domain binding 3/304 41/18639 0.0731707317073171 4.48628048780488 0.0290238677488048 0.250232805726182 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/304 17/18639 0.117647058823529 7.21323529411765 0.0306861574507467 0.25425673316333 GO:0019198 transmembrane receptor protein phosphatase activity 2/304 17/18639 0.117647058823529 7.21323529411765 0.0306861574507467 0.25425673316333 GO:0030169 low-density lipoprotein particle binding 2/304 17/18639 0.117647058823529 7.21323529411765 0.0306861574507467 0.25425673316333 GO:0030228 lipoprotein particle receptor activity 2/304 18/18639 0.111111111111111 6.8125 0.0341565266345249 0.275846379656037 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/304 18/18639 0.111111111111111 6.8125 0.0341565266345249 0.275846379656037 GO:0042578 phosphoric ester hydrolase activity 11/304 363/18639 0.0303030303030303 1.85795454545455 0.0365848160479093 0.291763907982077 GO:0046624 sphingolipid transporter activity 2/304 19/18639 0.105263157894737 6.45394736842105 0.0377714410903651 0.297508387847567 GO:0001784 phosphotyrosine residue binding 3/304 47/18639 0.0638297872340425 3.91356382978723 0.0411358556715885 0.319194444995932 GO:0031418 L-ascorbic acid binding 2/304 20/18639 0.1 6.13125 0.0415252961358345 0.319194444995932 GO:0038187 pattern recognition receptor activity 3/304 48/18639 0.0625 3.83203125 0.0433660419157083 0.329375413597879 GO:0008373 sialyltransferase activity 2/304 21/18639 0.0952380952380952 5.83928571428571 0.0454126304020686 0.340861861135526 GO:0001540 amyloid-beta binding 4/304 83/18639 0.0481927710843374 2.95481927710843 0.0468083319352911 0.343261100858801 GO:0030165 PDZ domain binding 4/304 83/18639 0.0481927710843374 2.95481927710843 0.0468083319352911 0.343261100858801 GO:0004866 endopeptidase inhibitor activity 6/304 161/18639 0.0372670807453416 2.28493788819876 0.0487293791803328 0.350390469630939 GO:0008093 cytoskeletal anchor activity 2/304 22/18639 0.0909090909090909 5.57386363636364 0.0494281226752108 0.350390469630939 GO:0070034 telomerase RNA binding 2/304 22/18639 0.0909090909090909 5.57386363636364 0.0494281226752108 0.350390469630939 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/304 86/18639 0.0465116279069767 2.85174418604651 0.0521209415493054 0.352256624456069 GO:0042277 peptide binding 8/304 249/18639 0.0321285140562249 1.96987951807229 0.0521409156646131 0.352256624456069 GO:0005080 protein kinase C binding 3/304 52/18639 0.0576923076923077 3.53725961538462 0.0528743998963218 0.352256624456069 GO:0005158 insulin receptor binding 2/304 23/18639 0.0869565217391304 5.33152173913043 0.0535665888022202 0.352256624456069 GO:0017134 fibroblast growth factor binding 2/304 23/18639 0.0869565217391304 5.33152173913043 0.0535665888022202 0.352256624456069 GO:0005544 calcium-dependent phospholipid binding 3/304 53/18639 0.0566037735849057 3.47051886792453 0.0553956149457472 0.352256624456069 GO:0051018 protein kinase A binding 3/304 53/18639 0.0566037735849057 3.47051886792453 0.0553956149457472 0.352256624456069 GO:0140296 general transcription initiation factor binding 3/304 53/18639 0.0566037735849057 3.47051886792453 0.0553956149457472 0.352256624456069 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/304 89/18639 0.0449438202247191 2.75561797752809 0.057748641348544 0.352256624456069 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/304 89/18639 0.0449438202247191 2.75561797752809 0.057748641348544 0.352256624456069 GO:0140297 DNA-binding transcription factor binding 13/304 488/18639 0.0266393442622951 1.63332479508197 0.0578000014687683 0.352256624456069 GO:0005540 hyaluronic acid binding 2/304 24/18639 0.0833333333333333 5.109375 0.057822978659799 0.352256624456069 GO:0030552 cAMP binding 2/304 24/18639 0.0833333333333333 5.109375 0.057822978659799 0.352256624456069 GO:0050699 WW domain binding 2/304 24/18639 0.0833333333333333 5.109375 0.057822978659799 0.352256624456069 GO:0015485 cholesterol binding 3/304 54/18639 0.0555555555555556 3.40625 0.0579732689151839 0.352256624456069 GO:0030414 peptidase inhibitor activity 6/304 169/18639 0.0355029585798817 2.17677514792899 0.0589622635107186 0.35488607660225 GO:0140793 histone H2AXY142 phosphatase activity 4/304 90/18639 0.0444444444444444 2.725 0.0596940557789207 0.355932781186462 GO:0035591 signaling adaptor activity 5/304 129/18639 0.0387596899224806 2.37645348837209 0.0603146371023127 0.356303133993292 GO:0003712 transcription coregulator activity 13/304 495/18639 0.0262626262626263 1.61022727272727 0.0631798247925593 0.369392347122672 GO:0043178 alcohol binding 4/304 92/18639 0.0434782608695652 2.66576086956522 0.0636883357108056 0.369392347122672 GO:0051213 dioxygenase activity 4/304 93/18639 0.043010752688172 2.63709677419355 0.0657368853207619 0.373117966460225 GO:0051219 phosphoprotein binding 4/304 93/18639 0.043010752688172 2.63709677419355 0.0657368853207619 0.373117966460225 GO:0034237 protein kinase A regulatory subunit binding 2/304 26/18639 0.0769230769230769 4.71634615384615 0.0666699814678145 0.373117966460225 GO:0052742 phosphatidylinositol kinase activity 2/304 26/18639 0.0769230769230769 4.71634615384615 0.0666699814678145 0.373117966460225 GO:0003735 structural constituent of ribosome 6/304 175/18639 0.0342857142857143 2.10214285714286 0.0674184948185285 0.374026084297576 GO:0061980 regulatory RNA binding 3/304 58/18639 0.0517241379310345 3.17133620689655 0.0688348992402897 0.377289447516668 GO:0005044 scavenger receptor activity 2/304 27/18639 0.0740740740740741 4.54166666666667 0.0712511379000494 0.377289447516668 GO:0015252 proton channel activity 2/304 27/18639 0.0740740740740741 4.54166666666667 0.0712511379000494 0.377289447516668 GO:0001786 phosphatidylserine binding 3/304 59/18639 0.0508474576271186 3.11758474576271 0.0716845237697486 0.377289447516668 GO:0045309 protein phosphorylated amino acid binding 3/304 59/18639 0.0508474576271186 3.11758474576271 0.0716845237697486 0.377289447516668 GO:0005319 lipid transporter activity 6/304 178/18639 0.0337078651685393 2.06671348314607 0.0718981949933306 0.377289447516668 GO:0044325 transmembrane transporter binding 5/304 136/18639 0.0367647058823529 2.25413602941176 0.0721462579890808 0.377289447516668 GO:0001098 basal transcription machinery binding 3/304 60/18639 0.05 3.065625 0.0745863507858429 0.37766739524895 GO:0001099 basal RNA polymerase II transcription machinery binding 3/304 60/18639 0.05 3.065625 0.0745863507858429 0.37766739524895 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/304 60/18639 0.05 3.065625 0.0745863507858429 0.37766739524895 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 3/304 60/18639 0.05 3.065625 0.0745863507858429 0.37766739524895 GO:0045499 chemorepellent activity 2/304 28/18639 0.0714285714285714 4.37946428571429 0.0759312993868569 0.378369780654756 GO:0097718 disordered domain specific binding 2/304 28/18639 0.0714285714285714 4.37946428571429 0.0759312993868569 0.378369780654756 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 6/304 181/18639 0.0331491712707182 2.03245856353591 0.0765451407372723 0.378369780654756 GO:0070851 growth factor receptor binding 5/304 139/18639 0.0359712230215827 2.20548561151079 0.0775791585920609 0.378369780654756 GO:0061134 peptidase regulator activity 7/304 226/18639 0.0309734513274336 1.89905973451327 0.0776903468115565 0.378369780654756 GO:0004713 protein tyrosine kinase activity 5/304 140/18639 0.0357142857142857 2.18973214285714 0.079437902634326 0.383949862732576 GO:0061135 endopeptidase regulator activity 6/304 184/18639 0.0326086956521739 1.99932065217391 0.0813586171610352 0.387680118664501 GO:0046982 protein heterodimerization activity 10/304 369/18639 0.02710027100271 1.66158536585366 0.0814249779013214 0.387680118664501 GO:0015078 proton transmembrane transporter activity 6/304 185/18639 0.0324324324324324 1.98851351351351 0.0829999523112882 0.392251626478533 GO:0019903 protein phosphatase binding 5/304 144/18639 0.0347222222222222 2.12890625 0.0871093152551923 0.403726255901487 GO:0030246 carbohydrate binding 8/304 280/18639 0.0285714285714286 1.75178571428571 0.0889030662134348 0.403726255901487 GO:0072349 modified amino acid transmembrane transporter activity 2/304 31/18639 0.0645161290322581 3.95564516129032 0.0905221639015876 0.403726255901487 GO:0019902 phosphatase binding 6/304 190/18639 0.0315789473684211 1.93618421052632 0.0914809161545551 0.403726255901487 GO:0043425 bHLH transcription factor binding 2/304 32/18639 0.0625 3.83203125 0.0955552704072901 0.403726255901487 GO:0071813 lipoprotein particle binding 2/304 32/18639 0.0625 3.83203125 0.0955552704072901 0.403726255901487 GO:0071814 protein-lipid complex binding 2/304 32/18639 0.0625 3.83203125 0.0955552704072901 0.403726255901487 GO:0005548 phospholipid transporter activity 3/304 68/18639 0.0441176470588235 2.70496323529412 0.0995843975162796 0.403726255901487 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/304 68/18639 0.0441176470588235 2.70496323529412 0.0995843975162796 0.403726255901487 GO:0032934 sterol binding 3/304 68/18639 0.0441176470588235 2.70496323529412 0.0995843975162796 0.403726255901487 GO:0005496 steroid binding 4/304 108/18639 0.037037037037037 2.27083333333333 0.100426999171662 0.403726255901487 GO:0030296 protein tyrosine kinase activator activity 2/304 33/18639 0.0606060606060606 3.71590909090909 0.100666410451325 0.403726255901487 GO:0005539 glycosaminoglycan binding 7/304 242/18639 0.0289256198347107 1.7735020661157 0.102141450805167 0.403726255901487 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 7/304 243/18639 0.0288065843621399 1.7662037037037 0.103794795806225 0.403726255901487 GO:0003774 cytoskeletal motor activity 5/304 153/18639 0.0326797385620915 2.00367647058824 0.105721919452639 0.403726255901487 GO:0015035 protein-disulfide reductase activity 2/304 34/18639 0.0588235294117647 3.60661764705882 0.105851720537922 0.403726255901487 GO:0090482 vitamin transmembrane transporter activity 2/304 34/18639 0.0588235294117647 3.60661764705882 0.105851720537922 0.403726255901487 GO:0004676 3-phosphoinositide-dependent protein kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0004711 ribosomal protein S6 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0035175 histone H3S10 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0035979 histone H2AXS139 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0044022 histone H3S28 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0044023 histone H4S1 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0044024 histone H2AS1 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0044025 histone H2BS14 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0072354 histone H3T3 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0072371 histone H2AS121 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0072518 Rho-dependent protein serine/threonine kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0140823 histone H2BS36 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0140855 histone H3S57 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0140995 histone H2A kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0140997 histone H4 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:0140998 histone H2B kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:1990244 histone H2AT120 kinase activity 7/304 245/18639 0.0285714285714286 1.75178571428571 0.107144901070717 0.403726255901487 GO:1902936 phosphatidylinositol bisphosphate binding 4/304 111/18639 0.036036036036036 2.20945945945946 0.108211940375557 0.403726255901487 GO:0004677 DNA-dependent protein kinase activity 7/304 246/18639 0.0284552845528455 1.74466463414634 0.108841561152125 0.403726255901487 GO:0140857 histone H3T45 kinase activity 7/304 246/18639 0.0284552845528455 1.74466463414634 0.108841561152125 0.403726255901487 GO:0035402 histone H3T11 kinase activity 7/304 247/18639 0.0283400809716599 1.7376012145749 0.110552556087915 0.405065987420616 GO:0035403 histone H3T6 kinase activity 7/304 247/18639 0.0283400809716599 1.7376012145749 0.110552556087915 0.405065987420616 GO:0005154 epidermal growth factor receptor binding 2/304 35/18639 0.0571428571428571 3.50357142857143 0.111107441690608 0.405065987420616 GO:0004679 AMP-activated protein kinase activity 7/304 248/18639 0.0282258064516129 1.73059475806452 0.112277830828668 0.407007136753921 GO:0001664 G protein-coupled receptor binding 8/304 297/18639 0.0269360269360269 1.65151515151515 0.114155754446209 0.41147667421854 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/304 36/18639 0.0555555555555556 3.40625 0.116429917089283 0.412679372794236 GO:0016409 palmitoyltransferase activity 2/304 36/18639 0.0555555555555556 3.40625 0.116429917089283 0.412679372794236 GO:0045505 dynein intermediate chain binding 2/304 36/18639 0.0555555555555556 3.40625 0.116429917089283 0.412679372794236 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 9/304 349/18639 0.0257879656160458 1.58112464183381 0.118879613758657 0.419034218663112 GO:0048029 monosaccharide binding 3/304 74/18639 0.0405405405405405 2.48564189189189 0.12023591489745 0.421486339036116 GO:0030551 cyclic nucleotide binding 2/304 37/18639 0.0540540540540541 3.31418918918919 0.121815589756151 0.421607498822937 GO:0043394 proteoglycan binding 2/304 37/18639 0.0540540540540541 3.31418918918919 0.121815589756151 0.421607498822937 GO:0031625 ubiquitin protein ligase binding 8/304 302/18639 0.0264900662251656 1.62417218543046 0.122252958122638 0.421607498822937 GO:0042887 amide transmembrane transporter activity 2/304 38/18639 0.0526315789473684 3.22697368421053 0.127261000289572 0.434184589223245 GO:0043531 ADP binding 2/304 38/18639 0.0526315789473684 3.22697368421053 0.127261000289572 0.434184589223245 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/304 39/18639 0.0512820512820513 3.14423076923077 0.132762784644874 0.447083677072191 GO:0015103 inorganic anion transmembrane transporter activity 5/304 165/18639 0.0303030303030303 1.85795454545455 0.1332977666426 0.447083677072191 GO:0019199 transmembrane receptor protein kinase activity 3/304 78/18639 0.0384615384615385 2.35817307692308 0.134803655677018 0.447083677072191 GO:0004177 aminopeptidase activity 2/304 40/18639 0.05 3.065625 0.138317671961229 0.447083677072191 GO:0015036 disulfide oxidoreductase activity 2/304 40/18639 0.05 3.065625 0.138317671961229 0.447083677072191 GO:0001530 lipopolysaccharide binding 2/304 41/18639 0.0487804878048781 2.99085365853659 0.143922482433661 0.447083677072191 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/304 41/18639 0.0487804878048781 2.99085365853659 0.143922482433661 0.447083677072191 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/304 41/18639 0.0487804878048781 2.99085365853659 0.143922482433661 0.447083677072191 GO:0033192 calmodulin-dependent protein phosphatase activity 3/304 81/18639 0.037037037037037 2.27083333333333 0.146108197884327 0.447083677072191 GO:0140791 histone H2AXS140 phosphatase activity 3/304 81/18639 0.037037037037037 2.27083333333333 0.146108197884327 0.447083677072191 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/304 81/18639 0.037037037037037 2.27083333333333 0.146108197884327 0.447083677072191 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/304 81/18639 0.037037037037037 2.27083333333333 0.146108197884327 0.447083677072191 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/304 81/18639 0.037037037037037 2.27083333333333 0.146108197884327 0.447083677072191 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/304 81/18639 0.037037037037037 2.27083333333333 0.146108197884327 0.447083677072191 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/304 81/18639 0.037037037037037 2.27083333333333 0.146108197884327 0.447083677072191 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/304 81/18639 0.037037037037037 2.27083333333333 0.146108197884327 0.447083677072191 GO:0019894 kinesin binding 2/304 42/18639 0.0476190476190476 2.91964285714286 0.149574125229322 0.447083677072191 GO:0035198 miRNA binding 2/304 42/18639 0.0476190476190476 2.91964285714286 0.149574125229322 0.447083677072191 GO:0048487 beta-tubulin binding 2/304 42/18639 0.0476190476190476 2.91964285714286 0.149574125229322 0.447083677072191 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/304 82/18639 0.0365853658536585 2.24314024390244 0.149943653578964 0.447083677072191 GO:0033549 MAP kinase phosphatase activity 3/304 82/18639 0.0365853658536585 2.24314024390244 0.149943653578964 0.447083677072191 GO:0008201 heparin binding 5/304 172/18639 0.0290697674418605 1.78234011627907 0.150728741991951 0.447083677072191 GO:0030957 Tat protein binding 1/304 10/18639 0.1 6.13125 0.151668352337193 0.447083677072191 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/304 10/18639 0.1 6.13125 0.151668352337193 0.447083677072191 GO:0051864 histone H3K36 demethylase activity 1/304 10/18639 0.1 6.13125 0.151668352337193 0.447083677072191 GO:0099122 RNA polymerase II C-terminal domain binding 1/304 10/18639 0.1 6.13125 0.151668352337193 0.447083677072191 GO:1990763 arrestin family protein binding 1/304 10/18639 0.1 6.13125 0.151668352337193 0.447083677072191 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/304 83/18639 0.036144578313253 2.21611445783133 0.153811228140601 0.447083677072191 GO:0008200 ion channel inhibitor activity 2/304 43/18639 0.0465116279069767 2.85174418604651 0.155269596447153 0.447083677072191 GO:0048156 tau protein binding 2/304 43/18639 0.0465116279069767 2.85174418604651 0.155269596447153 0.447083677072191 GO:0044389 ubiquitin-like protein ligase binding 8/304 322/18639 0.0248447204968944 1.52329192546584 0.157534792599498 0.447083677072191 GO:0017018 myosin phosphatase activity 3/304 84/18639 0.0357142857142857 2.18973214285714 0.157710012741026 0.447083677072191 GO:0051117 ATPase binding 3/304 84/18639 0.0357142857142857 2.18973214285714 0.157710012741026 0.447083677072191 GO:0003954 NADH dehydrogenase activity 2/304 44/18639 0.0454545454545455 2.78693181818182 0.161005977120079 0.447083677072191 GO:0016248 channel inhibitor activity 2/304 44/18639 0.0454545454545455 2.78693181818182 0.161005977120079 0.447083677072191 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/304 130/18639 0.0307692307692308 1.88653846153846 0.163217853888184 0.447083677072191 GO:0000099 sulfur amino acid transmembrane transporter activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0002162 dystroglycan binding 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0003953 NAD+ nucleosidase activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0008526 phosphatidylinositol transfer activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0010854 adenylate cyclase regulator activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0015217 ADP transmembrane transporter activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0032794 GTPase activating protein binding 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0050998 nitric-oxide synthase binding 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0180030 inositol phosphate kinase activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:1990948 ubiquitin ligase inhibitor activity 1/304 11/18639 0.0909090909090909 5.57386363636364 0.165511973620649 0.447083677072191 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/304 45/18639 0.0444444444444444 2.725 0.166780431258905 0.447083677072191 GO:0141110 transporter inhibitor activity 2/304 45/18639 0.0444444444444444 2.725 0.166780431258905 0.447083677072191 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 11/304 484/18639 0.0227272727272727 1.39346590909091 0.169337829297881 0.448177278175085 GO:0030276 clathrin binding 2/304 46/18639 0.0434782608695652 2.66576086956522 0.172590203937082 0.448177278175085 GO:0030291 protein serine/threonine kinase inhibitor activity 2/304 46/18639 0.0434782608695652 2.66576086956522 0.172590203937082 0.448177278175085 GO:0004197 cysteine-type endopeptidase activity 3/304 88/18639 0.0340909090909091 2.09019886363636 0.17359916360693 0.448177278175085 GO:0043495 protein-membrane adaptor activity 2/304 47/18639 0.0425531914893617 2.60904255319149 0.178432619415548 0.448177278175085 GO:0005078 MAP-kinase scaffold activity 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0005095 GTPase inhibitor activity 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0017166 vinculin binding 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0031543 peptidyl-proline dioxygenase activity 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0034452 dynactin binding 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0035251 UDP-glucosyltransferase activity 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0035497 cAMP response element binding 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0045295 gamma-catenin binding 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0070008 serine-type exopeptidase activity 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0070679 inositol 1,4,5 trisphosphate binding 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/304 12/18639 0.0833333333333333 5.109375 0.179130416825465 0.448177278175085 GO:0001216 DNA-binding transcription activator activity 11/304 491/18639 0.0224032586558045 1.37359979633401 0.180600115578317 0.450089350542837 GO:1901981 phosphatidylinositol phosphate binding 5/304 185/18639 0.027027027027027 1.65709459459459 0.185434270088673 0.459458004621298 GO:0072341 modified amino acid binding 3/304 91/18639 0.032967032967033 2.02129120879121 0.185799631962845 0.459458004621298 GO:0008035 high-density lipoprotein particle binding 1/304 13/18639 0.0769230769230769 4.71634615384615 0.192527332769259 0.461776083860103 GO:0008253 5'-nucleotidase activity 1/304 13/18639 0.0769230769230769 4.71634615384615 0.192527332769259 0.461776083860103 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/304 13/18639 0.0769230769230769 4.71634615384615 0.192527332769259 0.461776083860103 GO:0019855 calcium channel inhibitor activity 1/304 13/18639 0.0769230769230769 4.71634615384615 0.192527332769259 0.461776083860103 GO:0031994 insulin-like growth factor I binding 1/304 13/18639 0.0769230769230769 4.71634615384615 0.192527332769259 0.461776083860103 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/304 13/18639 0.0769230769230769 4.71634615384615 0.192527332769259 0.461776083860103 GO:0070700 BMP receptor binding 1/304 13/18639 0.0769230769230769 4.71634615384615 0.192527332769259 0.461776083860103 GO:0140666 annealing activity 1/304 13/18639 0.0769230769230769 4.71634615384615 0.192527332769259 0.461776083860103 GO:0015605 organophosphate ester transmembrane transporter activity 2/304 50/18639 0.04 2.4525 0.19613011478958 0.46211488685681 GO:0005010 insulin-like growth factor receptor activity 2/304 51/18639 0.0392156862745098 2.40441176470588 0.20207786437566 0.46211488685681 GO:0005021 vascular endothelial growth factor receptor activity 2/304 51/18639 0.0392156862745098 2.40441176470588 0.20207786437566 0.46211488685681 GO:0016597 amino acid binding 2/304 51/18639 0.0392156862745098 2.40441176470588 0.20207786437566 0.46211488685681 GO:0004867 serine-type endopeptidase inhibitor activity 3/304 95/18639 0.0315789473684211 1.93618421052632 0.202399717266531 0.46211488685681 GO:0004065 arylsulfatase activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0005161 platelet-derived growth factor receptor binding 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0005313 L-glutamate transmembrane transporter activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0005347 ATP transmembrane transporter activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0008559 ABC-type xenobiotic transporter activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0016530 metallochaperone activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0032454 histone H3K9 demethylase activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0042813 Wnt receptor activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0061665 SUMO ligase activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0071933 Arp2/3 complex binding 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:1901474 azole transmembrane transporter activity 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:1990825 sequence-specific mRNA binding 1/304 14/18639 0.0714285714285714 4.37946428571429 0.205706313271684 0.46211488685681 GO:0004896 cytokine receptor activity 3/304 96/18639 0.03125 1.916015625 0.206603384435665 0.462501611473525 GO:0030159 signaling receptor complex adaptor activity 2/304 52/18639 0.0384615384615385 2.35817307692308 0.208046002954833 0.464102621976166 GO:0005246 calcium channel regulator activity 2/304 53/18639 0.0377358490566038 2.31367924528302 0.21403229268068 0.467940170275577 GO:0008146 sulfotransferase activity 2/304 53/18639 0.0377358490566038 2.31367924528302 0.21403229268068 0.467940170275577 GO:0016860 intramolecular oxidoreductase activity 2/304 53/18639 0.0377358490566038 2.31367924528302 0.21403229268068 0.467940170275577 GO:0004089 carbonate dehydratase activity 1/304 15/18639 0.0666666666666667 4.0875 0.218670892104725 0.467940170275577 GO:0005041 low-density lipoprotein particle receptor activity 1/304 15/18639 0.0666666666666667 4.0875 0.218670892104725 0.467940170275577 GO:0005523 tropomyosin binding 1/304 15/18639 0.0666666666666667 4.0875 0.218670892104725 0.467940170275577 GO:0008252 nucleotidase activity 1/304 15/18639 0.0666666666666667 4.0875 0.218670892104725 0.467940170275577 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/304 15/18639 0.0666666666666667 4.0875 0.218670892104725 0.467940170275577 GO:0034483 heparan sulfate sulfotransferase activity 1/304 15/18639 0.0666666666666667 4.0875 0.218670892104725 0.467940170275577 GO:0047372 monoacylglycerol lipase activity 1/304 15/18639 0.0666666666666667 4.0875 0.218670892104725 0.467940170275577 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/304 15/18639 0.0666666666666667 4.0875 0.218670892104725 0.467940170275577 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/304 54/18639 0.037037037037037 2.27083333333333 0.220034562825507 0.467940170275577 GO:0017069 snRNA binding 2/304 54/18639 0.037037037037037 2.27083333333333 0.220034562825507 0.467940170275577 GO:0140463 chromatin-protein adaptor activity 2/304 54/18639 0.037037037037037 2.27083333333333 0.220034562825507 0.467940170275577 GO:0141003 histone H2AX kinase activity 8/304 354/18639 0.0225988700564972 1.38559322033898 0.222568352725765 0.471756176209428 GO:0140996 histone H3 kinase activity 8/304 357/18639 0.0224089635854342 1.37394957983193 0.229128631538989 0.47945178737963 GO:0005149 interleukin-1 receptor binding 1/304 16/18639 0.0625 3.83203125 0.231424545927758 0.47945178737963 GO:0015385 sodium:proton antiporter activity 1/304 16/18639 0.0625 3.83203125 0.231424545927758 0.47945178737963 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/304 16/18639 0.0625 3.83203125 0.231424545927758 0.47945178737963 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/304 16/18639 0.0625 3.83203125 0.231424545927758 0.47945178737963 GO:0070411 I-SMAD binding 1/304 16/18639 0.0625 3.83203125 0.231424545927758 0.47945178737963 GO:0170055 lipid transmembrane transporter activity 2/304 56/18639 0.0357142857142857 2.18973214285714 0.232078687597343 0.47945178737963 GO:0008238 exopeptidase activity 3/304 102/18639 0.0294117647058824 1.80330882352941 0.232210975392328 0.47945178737963 GO:0035173 histone kinase activity 8/304 360/18639 0.0222222222222222 1.3625 0.235757746785937 0.480788715800621 GO:0004722 protein serine/threonine phosphatase activity 3/304 103/18639 0.029126213592233 1.78580097087379 0.236535490947932 0.480788715800621 GO:0005253 monoatomic anion channel activity 3/304 103/18639 0.029126213592233 1.78580097087379 0.236535490947932 0.480788715800621 GO:0106310 protein serine kinase activity 8/304 361/18639 0.0221606648199446 1.35872576177285 0.237982286753895 0.480788715800621 GO:0003714 transcription corepressor activity 5/304 204/18639 0.0245098039215686 1.50275735294118 0.240658735382168 0.480788715800621 GO:0003713 transcription coactivator activity 6/304 256/18639 0.0234375 1.43701171875 0.240771225394856 0.480788715800621 GO:0008429 phosphatidylethanolamine binding 1/304 17/18639 0.0588235294117647 3.60661764705882 0.243970695207572 0.480788715800621 GO:0008484 sulfuric ester hydrolase activity 1/304 17/18639 0.0588235294117647 3.60661764705882 0.243970695207572 0.480788715800621 GO:0008569 minus-end-directed microtubule motor activity 1/304 17/18639 0.0588235294117647 3.60661764705882 0.243970695207572 0.480788715800621 GO:0015278 intracellularly gated calcium channel activity 1/304 17/18639 0.0588235294117647 3.60661764705882 0.243970695207572 0.480788715800621 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/304 17/18639 0.0588235294117647 3.60661764705882 0.243970695207572 0.480788715800621 GO:0032183 SUMO binding 1/304 17/18639 0.0588235294117647 3.60661764705882 0.243970695207572 0.480788715800621 GO:0038191 neuropilin binding 1/304 17/18639 0.0588235294117647 3.60661764705882 0.243970695207572 0.480788715800621 GO:0070492 oligosaccharide binding 1/304 17/18639 0.0588235294117647 3.60661764705882 0.243970695207572 0.480788715800621 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/304 58/18639 0.0344827586206897 2.11422413793103 0.244162294544516 0.480788715800621 GO:0015459 potassium channel regulator activity 2/304 59/18639 0.0338983050847458 2.07838983050847 0.250214146150648 0.489682899521821 GO:0070063 RNA polymerase binding 2/304 59/18639 0.0338983050847458 2.07838983050847 0.250214146150648 0.489682899521821 GO:0008525 phosphatidylcholine transporter activity 1/304 18/18639 0.0555555555555556 3.40625 0.256312705123633 0.492552728520716 GO:0015172 acidic amino acid transmembrane transporter activity 1/304 18/18639 0.0555555555555556 3.40625 0.256312705123633 0.492552728520716 GO:0031690 adrenergic receptor binding 1/304 18/18639 0.0555555555555556 3.40625 0.256312705123633 0.492552728520716 GO:0034185 apolipoprotein binding 1/304 18/18639 0.0555555555555556 3.40625 0.256312705123633 0.492552728520716 GO:0070064 proline-rich region binding 1/304 18/18639 0.0555555555555556 3.40625 0.256312705123633 0.492552728520716 GO:0098641 cadherin binding involved in cell-cell adhesion 1/304 18/18639 0.0555555555555556 3.40625 0.256312705123633 0.492552728520716 GO:0099106 ion channel regulator activity 4/304 160/18639 0.025 1.5328125 0.264989899027738 0.502268561761653 GO:0004222 metalloendopeptidase activity 3/304 110/18639 0.0272727272727273 1.67215909090909 0.26715616240684 0.502268561761653 GO:0003756 protein disulfide isomerase activity 1/304 19/18639 0.0526315789473684 3.22697368421053 0.268453886458815 0.502268561761653 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/304 19/18639 0.0526315789473684 3.22697368421053 0.268453886458815 0.502268561761653 GO:0005520 insulin-like growth factor binding 1/304 19/18639 0.0526315789473684 3.22697368421053 0.268453886458815 0.502268561761653 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/304 19/18639 0.0526315789473684 3.22697368421053 0.268453886458815 0.502268561761653 GO:0030506 ankyrin binding 1/304 19/18639 0.0526315789473684 3.22697368421053 0.268453886458815 0.502268561761653 GO:0034987 immunoglobulin receptor binding 1/304 19/18639 0.0526315789473684 3.22697368421053 0.268453886458815 0.502268561761653 GO:0046527 glucosyltransferase activity 1/304 19/18639 0.0526315789473684 3.22697368421053 0.268453886458815 0.502268561761653 GO:0005507 copper ion binding 2/304 63/18639 0.0317460317460317 1.94642857142857 0.274447187152325 0.511124579290197 GO:0005200 structural constituent of cytoskeleton 3/304 112/18639 0.0267857142857143 1.64229910714286 0.275994365613854 0.511124579290197 GO:0008514 organic anion transmembrane transporter activity 6/304 269/18639 0.0223048327137546 1.36756505576208 0.276320570138022 0.511124579290197 GO:0004674 protein serine/threonine kinase activity 9/304 433/18639 0.0207852193995381 1.27439376443418 0.276531690918034 0.511124579290197 GO:0001614 purinergic nucleotide receptor activity 1/304 20/18639 0.05 3.065625 0.280397496475814 0.511124579290197 GO:0010851 cyclase regulator activity 1/304 20/18639 0.05 3.065625 0.280397496475814 0.511124579290197 GO:0016502 nucleotide receptor activity 1/304 20/18639 0.05 3.065625 0.280397496475814 0.511124579290197 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/304 20/18639 0.05 3.065625 0.280397496475814 0.511124579290197 GO:0030742 GTP-dependent protein binding 1/304 20/18639 0.05 3.065625 0.280397496475814 0.511124579290197 GO:0019843 rRNA binding 2/304 65/18639 0.0307692307692308 1.88653846153846 0.286556012818861 0.51671032942793 GO:0038024 cargo receptor activity 2/304 65/18639 0.0307692307692308 1.88653846153846 0.286556012818861 0.51671032942793 GO:0120013 lipid transfer activity 2/304 65/18639 0.0307692307692308 1.88653846153846 0.286556012818861 0.51671032942793 GO:0015399 primary active transmembrane transporter activity 4/304 166/18639 0.0240963855421687 1.47740963855422 0.286701342660638 0.51671032942793 GO:0001846 opsonin binding 1/304 21/18639 0.0476190476190476 2.91964285714286 0.292146739779501 0.519584817061604 GO:0010314 phosphatidylinositol-5-phosphate binding 1/304 21/18639 0.0476190476190476 2.91964285714286 0.292146739779501 0.519584817061604 GO:0015125 bile acid transmembrane transporter activity 1/304 21/18639 0.0476190476190476 2.91964285714286 0.292146739779501 0.519584817061604 GO:0061891 calcium ion sensor activity 1/304 21/18639 0.0476190476190476 2.91964285714286 0.292146739779501 0.519584817061604 GO:1901681 sulfur compound binding 6/304 275/18639 0.0218181818181818 1.33772727272727 0.293134088096037 0.519584817061604 GO:0009055 electron transfer activity 3/304 116/18639 0.0258620689655172 1.58566810344828 0.293752229955284 0.519584817061604 GO:0016247 channel regulator activity 4/304 168/18639 0.0238095238095238 1.45982142857143 0.293997051660249 0.519584817061604 GO:0141108 transporter regulator activity 4/304 170/18639 0.0235294117647059 1.44264705882353 0.301316785030798 0.528214539962327 GO:0022853 active monoatomic ion transmembrane transporter activity 3/304 118/18639 0.0254237288135593 1.55879237288136 0.302660824693153 0.528214539962327 GO:0005243 gap junction channel activity 1/304 22/18639 0.0454545454545455 2.78693181818182 0.30370476916542 0.528214539962327 GO:0031683 G-protein beta/gamma-subunit complex binding 1/304 22/18639 0.0454545454545455 2.78693181818182 0.30370476916542 0.528214539962327 GO:0140784 metal ion sensor activity 1/304 22/18639 0.0454545454545455 2.78693181818182 0.30370476916542 0.528214539962327 GO:0003777 microtubule motor activity 2/304 68/18639 0.0294117647058824 1.80330882352941 0.304675471326232 0.528214539962327 GO:1990841 promoter-specific chromatin binding 2/304 68/18639 0.0294117647058824 1.80330882352941 0.304675471326232 0.528214539962327 GO:0000295 adenine nucleotide transmembrane transporter activity 1/304 23/18639 0.0434782608695652 2.66576086956522 0.315074686454656 0.538828910454302 GO:0005283 amino acid:sodium symporter activity 1/304 23/18639 0.0434782608695652 2.66576086956522 0.315074686454656 0.538828910454302 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/304 23/18639 0.0434782608695652 2.66576086956522 0.315074686454656 0.538828910454302 GO:0099186 structural constituent of postsynapse 1/304 23/18639 0.0434782608695652 2.66576086956522 0.315074686454656 0.538828910454302 GO:0003697 single-stranded DNA binding 3/304 121/18639 0.0247933884297521 1.52014462809917 0.316045828366878 0.538828910454302 GO:0015108 chloride transmembrane transporter activity 3/304 121/18639 0.0247933884297521 1.52014462809917 0.316045828366878 0.538828910454302 GO:0016782 transferase activity, transferring sulphur-containing groups 2/304 70/18639 0.0285714285714286 1.75178571428571 0.316709782790538 0.538828910454302 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0004622 lysophospholipase activity 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0005315 phosphate transmembrane transporter activity 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0035035 histone acetyltransferase binding 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0070300 phosphatidic acid binding 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0070840 dynein complex binding 1/304 24/18639 0.0416666666666667 2.5546875 0.326259543315302 0.542066637070736 GO:0001848 complement binding 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0005251 delayed rectifier potassium channel activity 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0005537 D-mannose binding 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0015271 outward rectifier potassium channel activity 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0019707 protein-cysteine S-acyltransferase activity 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0042974 nuclear retinoic acid receptor binding 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0120020 cholesterol transfer activity 1/304 25/18639 0.04 2.4525 0.337262342070722 0.544311008048301 GO:0031491 nucleosome binding 2/304 74/18639 0.027027027027027 1.65709459459459 0.340624318112509 0.544311008048301 GO:0004175 endopeptidase activity 8/304 405/18639 0.0197530864197531 1.21111111111111 0.341565977353836 0.544311008048301 GO:0042826 histone deacetylase binding 3/304 127/18639 0.0236220472440945 1.44832677165354 0.342833205039796 0.544311008048301 GO:0031490 chromatin DNA binding 3/304 128/18639 0.0234375 1.43701171875 0.347293029119183 0.544311008048301 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 3/304 128/18639 0.0234375 1.43701171875 0.347293029119183 0.544311008048301 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0008066 glutamate receptor activity 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0008157 protein phosphatase 1 binding 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0015216 purine nucleotide transmembrane transporter activity 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0030507 spectrin binding 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0051139 metal cation:proton antiporter activity 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0070006 metalloaminopeptidase activity 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0070412 R-SMAD binding 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0120014 phospholipid transfer activity 1/304 26/18639 0.0384615384615385 2.35817307692308 0.348086036494838 0.544311008048301 GO:0008237 metallopeptidase activity 4/304 184/18639 0.0217391304347826 1.33288043478261 0.352974363714658 0.550605486674699 GO:0003724 RNA helicase activity 2/304 77/18639 0.025974025974026 1.59253246753247 0.358389764008685 0.555514548047036 GO:0005104 fibroblast growth factor receptor binding 1/304 27/18639 0.037037037037037 2.27083333333333 0.358733532594638 0.555514548047036 GO:0035255 ionotropic glutamate receptor binding 1/304 27/18639 0.037037037037037 2.27083333333333 0.358733532594638 0.555514548047036 GO:0031406 carboxylic acid binding 4/304 187/18639 0.0213903743315508 1.31149732620321 0.364081206462469 0.560481995182225 GO:0005179 hormone activity 3/304 132/18639 0.0227272727272727 1.39346590909091 0.365098076463416 0.560481995182225 GO:0019789 SUMO transferase activity 1/304 28/18639 0.0357142857142857 2.18973214285714 0.369207689380111 0.560481995182225 GO:0046875 ephrin receptor binding 1/304 28/18639 0.0357142857142857 2.18973214285714 0.369207689380111 0.560481995182225 GO:0050698 proteoglycan sulfotransferase activity 1/304 28/18639 0.0357142857142857 2.18973214285714 0.369207689380111 0.560481995182225 GO:0051959 dynein light intermediate chain binding 1/304 28/18639 0.0357142857142857 2.18973214285714 0.369207689380111 0.560481995182225 GO:0141052 histone H3 demethylase activity 1/304 28/18639 0.0357142857142857 2.18973214285714 0.369207689380111 0.560481995182225 GO:0008186 ATP-dependent activity, acting on RNA 2/304 79/18639 0.0253164556962025 1.55221518987342 0.370136890061903 0.560481995182225 GO:0043177 organic acid binding 4/304 189/18639 0.0211640211640212 1.29761904761905 0.371482264528578 0.560481995182225 GO:0051087 protein-folding chaperone binding 3/304 134/18639 0.0223880597014925 1.37266791044776 0.373972587840377 0.560481995182225 GO:0048306 calcium-dependent protein binding 2/304 80/18639 0.025 1.5328125 0.375978713610911 0.560481995182225 GO:0033218 amide binding 5/304 247/18639 0.0202429149797571 1.24114372469636 0.376794075976651 0.560481995182225 GO:0015297 antiporter activity 3/304 135/18639 0.0222222222222222 1.3625 0.378401042579754 0.560481995182225 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/304 29/18639 0.0344827586206897 2.11422413793103 0.37951131962182 0.560481995182225 GO:0005416 amino acid:monoatomic cation symporter activity 1/304 29/18639 0.0344827586206897 2.11422413793103 0.37951131962182 0.560481995182225 GO:0016417 S-acyltransferase activity 1/304 29/18639 0.0344827586206897 2.11422413793103 0.37951131962182 0.560481995182225 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/304 29/18639 0.0344827586206897 2.11422413793103 0.37951131962182 0.560481995182225 GO:0097472 cyclin-dependent protein kinase activity 1/304 29/18639 0.0344827586206897 2.11422413793103 0.37951131962182 0.560481995182225 GO:0099604 ligand-gated calcium channel activity 1/304 29/18639 0.0344827586206897 2.11422413793103 0.37951131962182 0.560481995182225 GO:0106222 lncRNA binding 1/304 29/18639 0.0344827586206897 2.11422413793103 0.37951131962182 0.560481995182225 GO:0019787 ubiquitin-like protein transferase activity 9/304 479/18639 0.0187891440501044 1.15200939457202 0.380688926862003 0.56092271440637 GO:0015101 organic cation transmembrane transporter activity 2/304 81/18639 0.0246913580246914 1.51388888888889 0.381798220338166 0.561260978285138 GO:0016922 nuclear receptor binding 3/304 137/18639 0.0218978102189781 1.34260948905109 0.387237889973646 0.561604128962866 GO:0001965 G-protein alpha-subunit binding 1/304 30/18639 0.0333333333333333 2.04375 0.389647190596294 0.561604128962866 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/304 30/18639 0.0333333333333333 2.04375 0.389647190596294 0.561604128962866 GO:0015215 nucleotide transmembrane transporter activity 1/304 30/18639 0.0333333333333333 2.04375 0.389647190596294 0.561604128962866 GO:0032452 histone demethylase activity 1/304 30/18639 0.0333333333333333 2.04375 0.389647190596294 0.561604128962866 GO:0033612 receptor serine/threonine kinase binding 1/304 30/18639 0.0333333333333333 2.04375 0.389647190596294 0.561604128962866 GO:0051721 protein phosphatase 2A binding 1/304 30/18639 0.0333333333333333 2.04375 0.389647190596294 0.561604128962866 GO:0098918 structural constituent of synapse 1/304 30/18639 0.0333333333333333 2.04375 0.389647190596294 0.561604128962866 GO:0008236 serine-type peptidase activity 4/304 194/18639 0.0206185567010309 1.26417525773196 0.389953964154466 0.561604128962866 GO:0005254 chloride channel activity 2/304 83/18639 0.0240963855421687 1.47740963855422 0.393367013059407 0.564062610254004 GO:0030295 protein kinase activator activity 3/304 139/18639 0.0215827338129496 1.32329136690647 0.396044818747312 0.564062610254004 GO:0004860 protein kinase inhibitor activity 2/304 84/18639 0.0238095238095238 1.45982142857143 0.399114744774489 0.564062610254004 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/304 31/18639 0.032258064516129 1.97782258064516 0.399618024819451 0.564062610254004 GO:0005452 solute:inorganic anion antiporter activity 1/304 31/18639 0.032258064516129 1.97782258064516 0.399618024819451 0.564062610254004 GO:0008327 methyl-CpG binding 1/304 31/18639 0.032258064516129 1.97782258064516 0.399618024819451 0.564062610254004 GO:0017147 Wnt-protein binding 1/304 31/18639 0.032258064516129 1.97782258064516 0.399618024819451 0.564062610254004 GO:0070273 phosphatidylinositol-4-phosphate binding 1/304 31/18639 0.032258064516129 1.97782258064516 0.399618024819451 0.564062610254004 GO:0140457 protein demethylase activity 1/304 31/18639 0.032258064516129 1.97782258064516 0.399618024819451 0.564062610254004 GO:0019887 protein kinase regulator activity 5/304 255/18639 0.0196078431372549 1.20220588235294 0.402640808400754 0.567074692626228 GO:0061659 ubiquitin-like protein ligase activity 7/304 372/18639 0.0188172043010753 1.15372983870968 0.404666273815871 0.567440323234357 GO:0017171 serine hydrolase activity 4/304 198/18639 0.0202020202020202 1.23863636363636 0.404679227385004 0.567440323234357 GO:0030515 snoRNA binding 1/304 32/18639 0.03125 1.916015625 0.409426500768231 0.569093916100504 GO:0042910 xenobiotic transmembrane transporter activity 1/304 32/18639 0.03125 1.916015625 0.409426500768231 0.569093916100504 GO:0051059 NF-kappaB binding 1/304 32/18639 0.03125 1.916015625 0.409426500768231 0.569093916100504 GO:0120015 sterol transfer activity 1/304 32/18639 0.03125 1.916015625 0.409426500768231 0.569093916100504 GO:0019955 cytokine binding 3/304 144/18639 0.0208333333333333 1.27734375 0.417907522479701 0.577473027625971 GO:0019956 chemokine binding 1/304 33/18639 0.0303030303030303 1.85795454545455 0.419075253590634 0.577473027625971 GO:0140311 protein sequestering activity 1/304 33/18639 0.0303030303030303 1.85795454545455 0.419075253590634 0.577473027625971 GO:0140416 transcription regulator inhibitor activity 1/304 33/18639 0.0303030303030303 1.85795454545455 0.419075253590634 0.577473027625971 GO:0016755 aminoacyltransferase activity 9/304 496/18639 0.0181451612903226 1.1125252016129 0.420204332256051 0.577780956852071 GO:0016651 oxidoreductase activity, acting on NAD(P)H 2/304 88/18639 0.0227272727272727 1.39346590909091 0.421844547683859 0.578788863273767 GO:0008376 acetylgalactosaminyltransferase activity 1/304 34/18639 0.0294117647058824 1.80330882352941 0.428566875804352 0.582997157277563 GO:0015020 glucuronosyltransferase activity 1/304 34/18639 0.0294117647058824 1.80330882352941 0.428566875804352 0.582997157277563 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/304 34/18639 0.0294117647058824 1.80330882352941 0.428566875804352 0.582997157277563 GO:0030332 cyclin binding 1/304 34/18639 0.0294117647058824 1.80330882352941 0.428566875804352 0.582997157277563 GO:0019210 kinase inhibitor activity 2/304 90/18639 0.0222222222222222 1.3625 0.433043681473377 0.587833763361733 GO:0019209 kinase activator activity 3/304 148/18639 0.0202702702702703 1.24282094594595 0.435210803968156 0.589521216415464 GO:0005343 organic acid:sodium symporter activity 1/304 35/18639 0.0285714285714286 1.75178571428571 0.437903917984168 0.591573222905637 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/304 91/18639 0.021978021978022 1.34752747252747 0.438599727529793 0.591573222905637 GO:0008509 monoatomic anion transmembrane transporter activity 3/304 149/18639 0.0201342281879195 1.23447986577181 0.439507378773153 0.591573222905637 GO:0019842 vitamin binding 3/304 150/18639 0.02 1.22625 0.443791514514879 0.59608207633788 GO:0000993 RNA polymerase II complex binding 1/304 36/18639 0.0277777777777778 1.703125 0.447088889438308 0.597691516969656 GO:0055106 ubiquitin-protein transferase regulator activity 1/304 36/18639 0.0277777777777778 1.703125 0.447088889438308 0.597691516969656 GO:0005216 monoatomic ion channel activity 8/304 448/18639 0.0178571428571429 1.09486607142857 0.447800227447485 0.597691516969656 GO:0004842 ubiquitin-protein transferase activity 8/304 449/18639 0.0178173719376392 1.0924276169265 0.450264098244239 0.599725458621763 GO:0022829 wide pore channel activity 1/304 37/18639 0.027027027027027 1.65709459459459 0.456124258873924 0.606265160753257 GO:0005506 iron ion binding 3/304 154/18639 0.0194805194805195 1.19439935064935 0.460796689933719 0.611202262323727 GO:0005109 frizzled binding 1/304 38/18639 0.0263157894736842 1.61348684210526 0.465012455051879 0.615514411458711 GO:0140375 immune receptor activity 3/304 156/18639 0.0192307692307692 1.17908653846154 0.469215809476209 0.61942191778382 GO:0022804 active transmembrane transporter activity 8/304 457/18639 0.0175054704595186 1.07330415754923 0.469906282456691 0.61942191778382 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/304 39/18639 0.0256410256410256 1.57211538461538 0.473755867431011 0.623208749321618 GO:0030331 nuclear estrogen receptor binding 1/304 40/18639 0.025 1.5328125 0.48235684680203 0.629332654927802 GO:0032451 demethylase activity 1/304 40/18639 0.025 1.5328125 0.48235684680203 0.629332654927802 GO:0071855 neuropeptide receptor binding 1/304 40/18639 0.025 1.5328125 0.48235684680203 0.629332654927802 GO:0071949 FAD binding 1/304 40/18639 0.025 1.5328125 0.48235684680203 0.629332654927802 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/304 41/18639 0.024390243902439 1.49542682926829 0.49081770591124 0.637763129065929 GO:0140828 metal cation:monoatomic cation antiporter activity 1/304 41/18639 0.024390243902439 1.49542682926829 0.49081770591124 0.637763129065929 GO:0008083 growth factor activity 3/304 162/18639 0.0185185185185185 1.13541666666667 0.4941099844017 0.640736117984318 GO:0008307 structural constituent of muscle 1/304 42/18639 0.0238095238095238 1.45982142857143 0.499140720074214 0.643336928095653 GO:0031492 nucleosomal DNA binding 1/304 42/18639 0.0238095238095238 1.45982142857143 0.499140720074214 0.643336928095653 GO:0043175 RNA polymerase core enzyme binding 1/304 42/18639 0.0238095238095238 1.45982142857143 0.499140720074214 0.643336928095653 GO:0019207 kinase regulator activity 5/304 287/18639 0.0174216027874564 1.06816202090592 0.503864154300277 0.648115585571727 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/304 43/18639 0.0232558139534884 1.42587209302326 0.50732812777962 0.64995049301887 GO:0005245 voltage-gated calcium channel activity 1/304 43/18639 0.0232558139534884 1.42587209302326 0.50732812777962 0.64995049301887 GO:0001046 core promoter sequence-specific DNA binding 1/304 44/18639 0.0227272727272727 1.39346590909091 0.51538213128333 0.656314969578372 GO:0001223 transcription coactivator binding 1/304 44/18639 0.0227272727272727 1.39346590909091 0.51538213128333 0.656314969578372 GO:0043014 alpha-tubulin binding 1/304 44/18639 0.0227272727272727 1.39346590909091 0.51538213128333 0.656314969578372 GO:0061630 ubiquitin protein ligase activity 6/304 353/18639 0.0169971671388102 1.0421388101983 0.516837069250556 0.656638895086453 GO:0000149 SNARE binding 2/304 106/18639 0.0188679245283019 1.15683962264151 0.518128495487094 0.656638895086453 GO:0000287 magnesium ion binding 4/304 230/18639 0.0173913043478261 1.06630434782609 0.518724142826916 0.656638895086453 GO:0016887 ATP hydrolysis activity 7/304 417/18639 0.0167865707434053 1.02922661870504 0.522649277185002 0.658517799623508 GO:0042605 peptide antigen binding 1/304 45/18639 0.0222222222222222 1.3625 0.523304897192976 0.658517799623508 GO:0051539 4 iron, 4 sulfur cluster binding 1/304 45/18639 0.0222222222222222 1.3625 0.523304897192976 0.658517799623508 GO:0004180 carboxypeptidase activity 1/304 46/18639 0.0217391304347826 1.33288043478261 0.531098557043107 0.667009605105319 GO:0140359 ABC-type transporter activity 1/304 47/18639 0.0212765957446809 1.30452127659574 0.538765207861097 0.674192743193386 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1/304 48/18639 0.0208333333333333 1.27734375 0.546306912723954 0.674192743193386 GO:0032266 phosphatidylinositol-3-phosphate binding 1/304 48/18639 0.0208333333333333 1.27734375 0.546306912723954 0.674192743193386 GO:0140693 molecular condensate scaffold activity 1/304 48/18639 0.0208333333333333 1.27734375 0.546306912723954 0.674192743193386 GO:0004252 serine-type endopeptidase activity 3/304 176/18639 0.0170454545454545 1.04509943181818 0.549815905154578 0.674192743193386 GO:0005004 GPI-linked ephrin receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0005008 hepatocyte growth factor receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0005009 insulin receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0005011 macrophage colony-stimulating factor receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0005020 stem cell factor receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0008288 boss receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0035254 glutamate receptor binding 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0036332 placental growth factor receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0038062 protein tyrosine kinase collagen receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0060175 brain-derived neurotrophic factor receptor activity 1/304 49/18639 0.0204081632653061 1.25127551020408 0.553725701306166 0.674192743193386 GO:0005006 epidermal growth factor receptor activity 1/304 50/18639 0.02 1.22625 0.56102357041875 0.676675533087915 GO:0005007 fibroblast growth factor receptor activity 1/304 50/18639 0.02 1.22625 0.56102357041875 0.676675533087915 GO:0005017 platelet-derived growth factor receptor activity 1/304 50/18639 0.02 1.22625 0.56102357041875 0.676675533087915 GO:0005019 platelet-derived growth factor beta-receptor activity 1/304 50/18639 0.02 1.22625 0.56102357041875 0.676675533087915 GO:0035401 histone H3Y41 kinase activity 2/304 115/18639 0.0173913043478261 1.06630434782609 0.562128577643565 0.676675533087915 GO:0140801 histone H2AXY142 kinase activity 2/304 115/18639 0.0173913043478261 1.06630434782609 0.562128577643565 0.676675533087915 GO:0005030 neurotrophin receptor activity 1/304 51/18639 0.0196078431372549 1.20220588235294 0.568202484539612 0.681415761534346 GO:0005048 signal sequence binding 1/304 51/18639 0.0196078431372549 1.20220588235294 0.568202484539612 0.681415761534346 GO:0004864 protein phosphatase inhibitor activity 1/304 53/18639 0.0188679245283019 1.15683962264151 0.582211147174905 0.690428832523401 GO:0005003 ephrin receptor activity 1/304 53/18639 0.0188679245283019 1.15683962264151 0.582211147174905 0.690428832523401 GO:0005005 transmembrane-ephrin receptor activity 1/304 53/18639 0.0188679245283019 1.15683962264151 0.582211147174905 0.690428832523401 GO:0017046 peptide hormone binding 1/304 53/18639 0.0188679245283019 1.15683962264151 0.582211147174905 0.690428832523401 GO:0038064 collagen receptor activity 1/304 53/18639 0.0188679245283019 1.15683962264151 0.582211147174905 0.690428832523401 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/304 53/18639 0.0188679245283019 1.15683962264151 0.582211147174905 0.690428832523401 GO:0008234 cysteine-type peptidase activity 3/304 187/18639 0.0160427807486631 0.983622994652407 0.590967038318839 0.699512004540667 GO:0008528 G protein-coupled peptide receptor activity 2/304 122/18639 0.0163934426229508 1.00512295081967 0.594318875098765 0.699998534733577 GO:0046943 carboxylic acid transmembrane transporter activity 3/304 188/18639 0.0159574468085106 0.978390957446808 0.594586250241102 0.699998534733577 GO:0008374 O-acyltransferase activity 1/304 55/18639 0.0181818181818182 1.11477272727273 0.595766777994251 0.699998534733577 GO:0140313 molecular sequestering activity 1/304 55/18639 0.0181818181818182 1.11477272727273 0.595766777994251 0.699998534733577 GO:0005342 organic acid transmembrane transporter activity 3/304 189/18639 0.0158730158730159 0.973214285714286 0.598184701623562 0.701547499330575 GO:0015631 tubulin binding 6/304 385/18639 0.0155844155844156 0.955519480519481 0.601713559336741 0.703879095620762 GO:0019212 phosphatase inhibitor activity 1/304 56/18639 0.0178571428571429 1.09486607142857 0.60237928872874 0.703879095620762 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/304 57/18639 0.0175438596491228 1.07565789473684 0.608883980986527 0.708883174944169 GO:0016504 peptidase activator activity 1/304 57/18639 0.0175438596491228 1.07565789473684 0.608883980986527 0.708883174944169 GO:0001653 peptide receptor activity 2/304 128/18639 0.015625 0.9580078125 0.620480108646164 0.719720610484893 GO:0036002 pre-mRNA binding 1/304 59/18639 0.0169491525423729 1.03919491525424 0.621576890873316 0.719720610484893 GO:0070888 E-box binding 1/304 59/18639 0.0169491525423729 1.03919491525424 0.621576890873316 0.719720610484893 GO:0003924 GTPase activity 5/304 331/18639 0.0151057401812689 0.926170694864048 0.630301982753439 0.728501204704156 GO:0005262 calcium channel activity 2/304 131/18639 0.0152671755725191 0.936068702290076 0.633066510406686 0.729967801503372 GO:0016836 hydro-lyase activity 1/304 61/18639 0.0163934426229508 1.00512295081967 0.633859188139291 0.729967801503372 GO:0016757 glycosyltransferase activity 4/304 267/18639 0.0149812734082397 0.918539325842697 0.636297618767237 0.731455641033329 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 4/304 268/18639 0.0149253731343284 0.915111940298508 0.63920607036708 0.732898790638126 GO:0015179 L-amino acid transmembrane transporter activity 1/304 62/18639 0.0161290322580645 0.988911290322581 0.639850511575918 0.732898790638126 GO:0005261 monoatomic cation channel activity 5/304 341/18639 0.0146627565982405 0.899010263929619 0.656180977179964 0.750257102940532 GO:0008017 microtubule binding 4/304 276/18639 0.0144927536231884 0.888586956521739 0.661926329207849 0.755180491397144 GO:0008235 metalloexopeptidase activity 1/304 66/18639 0.0151515151515152 0.928977272727273 0.662854349815675 0.755180491397144 GO:0001217 DNA-binding transcription repressor activity 4/304 278/18639 0.0143884892086331 0.882194244604317 0.667453017772937 0.757943001191544 GO:0016500 protein-hormone receptor activity 1/304 67/18639 0.0149253731343284 0.915111940298508 0.668372697829245 0.757943001191544 GO:0008094 ATP-dependent activity, acting on DNA 3/304 210/18639 0.0142857142857143 0.875892857142857 0.668843118606331 0.757943001191544 GO:0030145 manganese ion binding 1/304 68/18639 0.0147058823529412 0.901654411764706 0.673801014642723 0.762207530748328 GO:0002039 p53 binding 1/304 69/18639 0.0144927536231884 0.888586956521739 0.679140764335718 0.766684821522338 GO:0022843 voltage-gated monoatomic cation channel activity 2/304 143/18639 0.013986013986014 0.857517482517482 0.680162396522952 0.766684821522338 GO:0008028 monocarboxylic acid transmembrane transporter activity 1/304 70/18639 0.0142857142857143 0.875892857142857 0.684393387256662 0.770093441040124 GO:0008194 UDP-glycosyltransferase activity 2/304 145/18639 0.0137931034482759 0.845689655172414 0.687514952314055 0.772243907704872 GO:0140299 molecular sensor activity 1/304 71/18639 0.0140845070422535 0.863556338028169 0.689560300406211 0.77318009078939 GO:0015291 secondary active transmembrane transporter activity 4/304 287/18639 0.0139372822299652 0.854529616724739 0.691556014330736 0.774057433584227 GO:0015085 calcium ion transmembrane transporter activity 2/304 147/18639 0.0136054421768707 0.834183673469388 0.694728497922922 0.776246552845577 GO:0043539 protein serine/threonine kinase activator activity 1/304 73/18639 0.0136986301369863 0.839897260273973 0.699642550912136 0.780370537555844 GO:0035064 methylated histone binding 1/304 74/18639 0.0135135135135135 0.828547297297297 0.704560608895693 0.782873386611632 GO:0000510 H3-H4 histone complex chaperone activity 2/304 151/18639 0.0132450331125828 0.812086092715232 0.70874368430544 0.782873386611632 GO:0140584 chromatin extrusion motor activity 2/304 151/18639 0.0132450331125828 0.812086092715232 0.70874368430544 0.782873386611632 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/304 151/18639 0.0132450331125828 0.812086092715232 0.70874368430544 0.782873386611632 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/304 151/18639 0.0132450331125828 0.812086092715232 0.70874368430544 0.782873386611632 GO:0015616 DNA translocase activity 2/304 152/18639 0.0131578947368421 0.806743421052632 0.712162652677217 0.782873386611632 GO:0140674 ATP-dependent histone chaperone activity 2/304 152/18639 0.0131578947368421 0.806743421052632 0.712162652677217 0.782873386611632 GO:0017022 myosin binding 1/304 76/18639 0.0131578947368421 0.806743421052632 0.714157227285219 0.782873386611632 GO:0051536 iron-sulfur cluster binding 1/304 76/18639 0.0131578947368421 0.806743421052632 0.714157227285219 0.782873386611632 GO:0140034 methylation-dependent protein binding 1/304 76/18639 0.0131578947368421 0.806743421052632 0.714157227285219 0.782873386611632 GO:0061775 cohesin loader activity 2/304 153/18639 0.0130718954248366 0.801470588235294 0.715548041749901 0.783052573990458 GO:0051540 metal cluster binding 1/304 77/18639 0.012987012987013 0.796266233766234 0.718838378117805 0.785306310341027 GO:0004386 helicase activity 2/304 155/18639 0.0129032258064516 0.791129032258065 0.722218811804046 0.787650601591421 GO:0015370 solute:sodium symporter activity 1/304 79/18639 0.0126582278481013 0.776107594936709 0.727972682370784 0.791220734842522 GO:0016835 carbon-oxygen lyase activity 1/304 79/18639 0.0126582278481013 0.776107594936709 0.727972682370784 0.791220734842522 GO:0140658 ATP-dependent chromatin remodeler activity 2/304 158/18639 0.0126582278481013 0.776107594936709 0.731977759546599 0.794220766310766 GO:0003689 DNA clamp loader activity 2/304 160/18639 0.0125 0.76640625 0.738321169367409 0.799743473779978 GO:0015081 sodium ion transmembrane transporter activity 2/304 164/18639 0.0121951219512195 0.747713414634146 0.750625028144681 0.810319404325391 GO:0140713 histone chaperone activity 2/304 164/18639 0.0121951219512195 0.747713414634146 0.750625028144681 0.810319404325391 GO:0016209 antioxidant activity 1/304 86/18639 0.0116279069767442 0.712936046511628 0.757675167689249 0.815171596940541 GO:0050660 flavin adenine dinucleotide binding 1/304 86/18639 0.0116279069767442 0.712936046511628 0.757675167689249 0.815171596940541 GO:0016874 ligase activity 2/304 167/18639 0.0119760479041916 0.734281437125749 0.759524294193709 0.815785353022873 GO:0008081 phosphoric diester hydrolase activity 1/304 87/18639 0.0114942528735632 0.704741379310345 0.761645778858465 0.816689087246556 GO:0140104 molecular carrier activity 3/304 249/18639 0.0120481927710843 0.738704819277108 0.77508484237387 0.829704915158606 GO:0005244 voltage-gated monoatomic ion channel activity 2/304 173/18639 0.0115606936416185 0.708815028901734 0.776502478623372 0.829830119533855 GO:0022832 voltage-gated channel activity 2/304 175/18639 0.0114285714285714 0.700714285714286 0.781925134064288 0.834227818617083 GO:0042562 hormone binding 1/304 94/18639 0.0106382978723404 0.652260638297872 0.787682196673679 0.838967014153268 GO:0016853 isomerase activity 2/304 180/18639 0.0111111111111111 0.68125 0.794980521809399 0.84532928819066 GO:0005249 voltage-gated potassium channel activity 1/304 98/18639 0.0102040816326531 0.625637755102041 0.801266403090803 0.849182666398558 GO:0042626 ATPase-coupled transmembrane transporter activity 1/304 98/18639 0.0102040816326531 0.625637755102041 0.801266403090803 0.849182666398558 GO:0003730 mRNA 3'-UTR binding 3/304 262/18639 0.0114503816793893 0.702051526717557 0.803665553279357 0.850312807615638 GO:0015171 amino acid transmembrane transporter activity 1/304 102/18639 0.00980392156862745 0.601102941176471 0.813984160422575 0.858861185657666 GO:0140597 protein carrier chaperone 2/304 188/18639 0.0106382978723404 0.652260638297872 0.814437331227098 0.858861185657666 GO:0004497 monooxygenase activity 1/304 106/18639 0.00943396226415094 0.578419811320755 0.825890563141272 0.869501946013418 GO:0019888 protein phosphatase regulator activity 1/304 107/18639 0.00934579439252336 0.573014018691589 0.828746510306062 0.871071290898299 GO:0004620 phospholipase activity 1/304 109/18639 0.00917431192660551 0.5625 0.834319080584395 0.874075075706322 GO:0016758 hexosyltransferase activity 2/304 197/18639 0.0101522842639594 0.62246192893401 0.834344390446944 0.874075075706322 GO:0001221 transcription coregulator binding 1/304 115/18639 0.00869565217391304 0.533152173913043 0.849975457649225 0.888990724557714 GO:0015294 solute:monoatomic cation symporter activity 1/304 116/18639 0.00862068965517241 0.528556034482759 0.852437531762517 0.890106620727473 GO:0019208 phosphatase regulator activity 1/304 117/18639 0.00854700854700855 0.524038461538462 0.854859331165648 0.891176884450464 GO:0046873 metal ion transmembrane transporter activity 5/304 450/18639 0.0111111111111111 0.68125 0.861105435709613 0.895579090249138 GO:0032182 ubiquitin-like protein binding 1/304 120/18639 0.00833333333333333 0.5109375 0.861889594691177 0.895579090249138 GO:0005267 potassium channel activity 1/304 124/18639 0.00806451612903226 0.49445564516129 0.870738072784094 0.903302260871954 GO:0019783 ubiquitin-like protein peptidase activity 1/304 127/18639 0.0078740157480315 0.482775590551181 0.877001536611656 0.908323020062073 GO:0016298 lipase activity 1/304 130/18639 0.00769230769230769 0.471634615384615 0.882962450518143 0.913014657099798 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/304 229/18639 0.00873362445414847 0.535480349344978 0.890440582407417 0.919257429734518 GO:0099094 ligand-gated monoatomic cation channel activity 1/304 136/18639 0.00735294117647059 0.450827205882353 0.894034203071811 0.92016089529013 GO:0022836 gated channel activity 3/304 318/18639 0.00943396226415094 0.578419811320755 0.894200243071913 0.92016089529013 GO:0005125 cytokine activity 2/304 234/18639 0.00854700854700855 0.524038461538462 0.897424017609081 0.921991180732035 GO:0020037 heme binding 1/304 142/18639 0.00704225352112676 0.431778169014085 0.904061685696668 0.927317291759605 GO:0015293 symporter activity 1/304 146/18639 0.00684931506849315 0.419948630136986 0.910215406461641 0.932130705172595 GO:0140097 catalytic activity, acting on DNA 3/304 336/18639 0.00892857142857143 0.547433035714286 0.914116589453687 0.934625615499122 GO:0046906 tetrapyrrole binding 1/304 152/18639 0.00657894736842105 0.403371710526316 0.918716077715904 0.937825372132395 GO:0015079 potassium ion transmembrane transporter activity 1/304 160/18639 0.00625 0.383203125 0.928815337260866 0.946620104109317 GO:0005126 cytokine receptor binding 2/304 275/18639 0.00727272727272727 0.445909090909091 0.940878401440435 0.957073117031414 GO:0140030 modification-dependent protein binding 1/304 173/18639 0.00578034682080925 0.354407514450867 0.942627581361548 0.957073117031414 GO:0003823 antigen binding 1/304 174/18639 0.00574712643678161 0.352370689655172 0.943572085599937 0.957073117031414 GO:0043021 ribonucleoprotein complex binding 1/304 177/18639 0.00564971751412429 0.346398305084746 0.946313615564531 0.958330296397097 GO:0005525 GTP binding 3/304 378/18639 0.00793650793650794 0.486607142857143 0.94802562382858 0.958542548340149 GO:0015276 ligand-gated monoatomic ion channel activity 1/304 186/18639 0.00537634408602151 0.329637096774194 0.953766863139366 0.962821611840057 GO:0022834 ligand-gated channel activity 1/304 188/18639 0.00531914893617021 0.326130319148936 0.955277671807561 0.962823309025631 GO:0019001 guanyl nucleotide binding 3/304 400/18639 0.0075 0.45984375 0.960358276361503 0.964895402076597 GO:0032561 guanyl ribonucleotide binding 3/304 400/18639 0.0075 0.45984375 0.960358276361503 0.964895402076597 GO:0016829 lyase activity 1/304 200/18639 0.005 0.3065625 0.963363199997133 0.966392644022282 GO:0042393 histone binding 1/304 247/18639 0.00404858299595142 0.248228744939271 0.983244430337171 0.984787985172865 GO:0140098 catalytic activity, acting on RNA 2/304 387/18639 0.00516795865633075 0.316860465116279 0.987835044869883 0.987835044869883