category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 2/3 227/9376 27.5359765051395 FOS/MT-ND3 7.24049313052952 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 2/3 238/9376 26.2633053221288 RPS26/FOS 7.0625255102746 Human Diseases Substance dependence hsa05031 Amphetamine addiction 1/3 69/9376 45.2946859903382 FOS 6.60660395078075 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 1/3 71/9376 44.018779342723 FOS 6.50932605066819 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 1/3 78/9376 40.0683760683761 FOS 6.19847490131751 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 1/3 78/9376 40.0683760683761 FOS 6.19847490131751 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 1/3 87/9376 35.9233716475096 FOS 5.85461400869871 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 1/3 90/9376 34.7259259259259 FOS 5.75145536736989 Organismal Systems Immune system hsa04662 B cell receptor signaling pathway 1/3 91/9376 34.3443223443223 FOS 5.71819017335185 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 1/3 93/9376 33.6057347670251 FOS 5.65325073060634 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 1/3 94/9376 33.2482269503546 FOS 5.62154825996236 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 1/3 95/9376 32.8982456140351 FOS 5.59033934324967 Organismal Systems Environmental adaptation hsa04713 Circadian entrainment 1/3 97/9376 32.2199312714777 FOS 5.52935125336757 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 1/3 99/9376 31.5690235690236 FOS 5.47018913812489 Human Diseases Cancer: overview hsa05231 Choline metabolism in cancer 1/3 99/9376 31.5690235690236 FOS 5.47018913812489 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 1/3 103/9376 30.3430420711974 FOS 5.35698679471294 Organismal Systems Immune system hsa04620 Toll-like receptor signaling pathway 1/3 109/9376 28.6727828746177 FOS 5.19880418727079 Organismal Systems Immune system hsa04659 Th17 cell differentiation 1/3 109/9376 28.6727828746177 FOS 5.19880418727079 Organismal Systems Nervous system hsa04725 Cholinergic synapse 1/3 115/9376 27.1768115942029 FOS 5.05293465950481 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 1/3 115/9376 27.1768115942029 FOS 5.05293465950481 Environmental Information Processing Signal transduction hsa04668 TNF signaling pathway 1/3 119/9376 26.2633053221288 FOS 4.96175683579833 Organismal Systems Immune system hsa04660 T cell receptor signaling pathway 1/3 122/9376 25.6174863387978 FOS 4.8962753196337 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 1/3 122/9376 25.6174863387978 FOS 4.8962753196337 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 1/3 130/9376 24.0410256410256 FOS 4.73264028160841 Organismal Systems Nervous system hsa04728 Dopaminergic synapse 1/3 133/9376 23.4987468671679 FOS 4.67503245856653 Human Diseases Infectious disease: viral hsa05162 Measles 1/3 136/9376 22.9803921568627 FOS 4.61929674254267 Cellular Processes Cell growth and death hsa04210 Apoptosis 1/3 137/9376 22.8126520681265 FOS 4.60111649340454 Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 1/3 138/9376 22.6473429951691 MT-ND3 4.58312940492739 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 1/3 138/9376 22.6473429951691 FOS 4.58312940492739 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 1/3 139/9376 22.484412470024 FOS 4.56533201265864 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 1/3 142/9376 22.0093896713615 FOS 4.51304465094907 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 1/3 142/9376 22.0093896713615 FOS 4.51304465094907 Human Diseases Cancer: specific types hsa05224 Breast cancer 1/3 148/9376 21.1171171171171 FOS 4.41316094440829 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 1/3 149/9376 20.9753914988814 MT-ND3 4.397087731 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 1/3 154/9376 20.2943722943723 FOS 4.31902196497736 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 1/3 157/9376 19.9065817409766 FOS 4.27393479834231 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 1/3 163/9376 19.1738241308793 FOS 4.18742020937752 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 1/3 196/9376 15.9455782312925 FOS 3.78291318168755 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 1/3 200/9376 15.6266666666667 FOS 3.74059437646732 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 1/3 205/9376 15.2455284552846 MT-ND3 3.68938608480611 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 1/3 214/9376 14.6043613707165 FOS 3.60161145977969 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 1/3 216/9376 14.4691358024691 FOS 3.58282691026049 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 1/3 217/9376 14.4024577572965 FOS 3.57352842956767 Genetic Information Processing Translation hsa03010 Ribosome 1/3 222/9376 14.0780780780781 RPS26 3.52794589455205 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 1/3 224/9376 13.952380952381 FOS 3.51012489712226 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 1/3 226/9376 13.8289085545723 FOS 3.49253155819686 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 1/3 235/9376 13.2992907801418 MT-ND3 3.41604908917404 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 1/3 248/9376 12.6021505376344 FOS 3.31271045141385 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 1/3 268/9376 11.6616915422886 MT-ND3 3.16802760133941 Human Diseases Neurodegenerative disease hsa05020 Prion disease 1/3 275/9376 11.3648484848485 MT-ND3 3.12098516734966 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 1/3 300/9376 10.4177777777778 FOS 2.96598383269391 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 1/3 308/9376 10.1471861471861 MT-ND3 2.92020995224 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 1/3 368/9376 8.4927536231884 MT-ND3 2.62336143574495 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 1/3 388/9376 8.05498281786942 MT-ND3 2.5391435150999 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 1/3 480/9376 6.51111111111111 MT-ND3 2.21752924298393