ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 38/131 175/18639 0.217142857142857 30.8956161395856 8.82766412900948e-47 2.78071420063799e-44 GO:1990948 ubiquitin ligase inhibitor activity 4/131 11/18639 0.363636363636364 51.7390700902151 7.40230154013645e-07 0.000116586249257149 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/131 15/18639 0.266666666666667 37.9419847328244 2.99573411134621e-06 0.000314552081691352 GO:0055106 ubiquitin-protein transferase regulator activity 5/131 36/18639 0.138888888888889 19.7614503816794 5.02722002654633e-06 0.000395893577090524 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 6/131 68/18639 0.0882352941176471 12.5543331836551 8.22846049799679e-06 0.000510088541925226 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/131 41/18639 0.121951219512195 17.3515174083039 9.71597222714717e-06 0.000510088541925226 GO:0003954 NADH dehydrogenase activity 5/131 44/18639 0.113636363636364 16.1684594031922 1.384449743289e-05 0.000623002384480052 GO:0015078 proton transmembrane transporter activity 8/131 185/18639 0.0432432432432432 6.15275428099856 4.9522631726585e-05 0.00188977607961176 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/131 58/18639 0.0862068965517241 12.2657278231113 5.39936022746217e-05 0.00188977607961176 GO:0097371 MDM2/MDM4 family protein binding 3/131 12/18639 0.25 35.5706106870229 7.12634650028564e-05 0.00224479914758998 GO:0019843 rRNA binding 5/131 65/18639 0.0769230769230769 10.9448032883147 9.35813704289387e-05 0.00267983015319234 GO:0009055 electron transfer activity 6/131 116/18639 0.0517241379310345 7.35943669386681 0.000169454316130821 0.00444817579843404 GO:0022853 active monoatomic ion transmembrane transporter activity 6/131 118/18639 0.0508474576271186 7.23470047871652 0.000186044278129893 0.00450799597007048 GO:0016651 oxidoreductase activity, acting on NAD(P)H 5/131 88/18639 0.0568181818181818 8.08422970159611 0.000390198771752824 0.00877947236443853 GO:0048027 mRNA 5'-UTR binding 3/131 24/18639 0.125 17.7853053435114 0.000616394435940921 0.0127841381364362 GO:0030695 GTPase regulator activity 11/131 489/18639 0.0224948875255624 3.20062754648059 0.000678449038169434 0.0127841381364362 GO:0060589 nucleoside-triphosphatase regulator activity 11/131 490/18639 0.0224489795918367 3.19409565352859 0.000689937613712428 0.0127841381364362 GO:0045309 protein phosphorylated amino acid binding 4/131 59/18639 0.0677966101694915 9.64626730495536 0.000786463593526239 0.0137631128867092 GO:0015399 primary active transmembrane transporter activity 6/131 166/18639 0.036144578313253 5.14273889450933 0.00113905005574556 0.0188842509242027 GO:0005154 epidermal growth factor receptor binding 3/131 35/18639 0.0857142857142857 12.1956379498364 0.00188401097729859 0.0296731728924527 GO:0044389 ubiquitin-like protein ligase binding 8/131 322/18639 0.0248447204968944 3.53496752169172 0.00200390411366174 0.0300585617049261 GO:0034713 type I transforming growth factor beta receptor binding 2/131 11/18639 0.181818181818182 25.8695350451076 0.00258652394103793 0.0370343200648613 GO:0005096 GTPase activator activity 7/131 271/18639 0.025830258302583 3.67519224810569 0.00307177930991589 0.0420700209836307 GO:0001223 transcription coactivator binding 3/131 44/18639 0.0681818181818182 9.70107564191534 0.00364109901855583 0.0477894246185452 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/131 45/18639 0.0666666666666667 9.48549618320611 0.00388133814506261 0.0489048606277889 GO:0051219 phosphoprotein binding 4/131 93/18639 0.043010752688172 6.11967495690717 0.00420044250465037 0.0508899764986487 GO:0001784 phosphotyrosine residue binding 3/131 47/18639 0.0638297872340425 9.08185804775053 0.00439025497311713 0.0512196413530332 GO:0005085 guanyl-nucleotide exchange factor activity 6/131 230/18639 0.0260869565217391 3.7117158977763 0.00575265886972795 0.0647174122844394 GO:0070492 oligosaccharide binding 2/131 17/18639 0.117647058823529 16.7391109115402 0.00622179995970446 0.0675816202519623 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/131 18/18639 0.111111111111111 15.8091603053435 0.00696748927837516 0.0731586374229392 GO:0003924 GTPase activity 7/131 331/18639 0.0211480362537764 3.00899425751251 0.00895938401717387 0.0910389021099925 GO:0035591 signaling adaptor activity 4/131 129/18639 0.0310077519379845 4.41185868986331 0.0130639854098944 0.125871726901616 GO:0005126 cytokine receptor binding 6/131 275/18639 0.0218181818181818 3.10434420541291 0.0131865618658835 0.125871726901616 GO:0005160 transforming growth factor beta receptor binding 2/131 26/18639 0.0769230769230769 10.9448032883147 0.0142682289725169 0.132190944892436 GO:0015252 proton channel activity 2/131 27/18639 0.0740740740740741 10.5394402035623 0.0153395125610515 0.138055613049463 GO:0046875 ephrin receptor binding 2/131 28/18639 0.0714285714285714 10.1630316248637 0.0164442887048666 0.143887526167583 GO:0046332 SMAD binding 3/131 79/18639 0.0379746835443038 5.4031307372693 0.018205960508272 0.154996690813667 GO:0005164 tumor necrosis factor receptor binding 2/131 31/18639 0.0645161290322581 9.17951243536075 0.0199544382892305 0.161369784676805 GO:0031625 ubiquitin protein ligase binding 6/131 302/18639 0.0198675496688742 2.82680349830646 0.0199791161980807 0.161369784676805 GO:0071889 14-3-3 protein binding 2/131 33/18639 0.0606060606060606 8.62317834836919 0.022452683553815 0.176814882986293 GO:0000146 microfilament motor activity 2/131 38/18639 0.0526315789473684 7.48854961832061 0.0292232688687805 0.224520236430875 GO:0001046 core promoter sequence-specific DNA binding 2/131 44/18639 0.0454545454545455 6.46738376127689 0.0382709172929252 0.287031879696939 GO:0042605 peptide antigen binding 2/131 45/18639 0.0444444444444444 6.3236641221374 0.0398704326021281 0.29207409929466 GO:1901981 phosphatidylinositol phosphate binding 4/131 185/18639 0.0216216216216216 3.07637714049928 0.0416777753649801 0.297919830323074 GO:0022804 active transmembrane transporter activity 7/131 457/18639 0.0153172866520788 2.17938096113051 0.0426405466601125 0.297919830323074 GO:0032266 phosphatidylinositol-3-phosphate binding 2/131 48/18639 0.0416666666666667 5.92843511450382 0.0448173055606696 0.297919830323074 GO:0035254 glutamate receptor binding 2/131 49/18639 0.0408163265306122 5.80744664277925 0.0465143058810711 0.297919830323074 GO:0001221 transcription coregulator binding 3/131 115/18639 0.0260869565217391 3.7117158977763 0.0474668724643485 0.297919830323074 GO:0035401 histone H3Y41 kinase activity 3/131 115/18639 0.0260869565217391 3.7117158977763 0.0474668724643485 0.297919830323074 GO:0140801 histone H2AXY142 kinase activity 3/131 115/18639 0.0260869565217391 3.7117158977763 0.0474668724643485 0.297919830323074 GO:0032813 tumor necrosis factor receptor superfamily binding 2/131 50/18639 0.04 5.69129770992366 0.0482346391951643 0.297919830323074 GO:0035091 phosphatidylinositol binding 5/131 284/18639 0.0176056338028169 2.50497258359316 0.0502833815311098 0.301838159587232 GO:0005525 GTP binding 6/131 378/18639 0.0158730158730159 2.25845147219193 0.0508280334544292 0.301838159587232 GO:0030159 signaling receptor complex adaptor activity 2/131 52/18639 0.0384615384615385 5.47240164415737 0.0517436845006684 0.301838159587232 GO:0140463 chromatin-protein adaptor activity 2/131 54/18639 0.037037037037037 5.26972010178117 0.0553412454098715 0.316954405529264 GO:0051015 actin filament binding 4/131 209/18639 0.0191387559808612 2.72310895211659 0.0600938307232901 0.318258198282874 GO:0019001 guanyl nucleotide binding 6/131 400/18639 0.015 2.13423664122137 0.063336745114181 0.318258198282874 GO:0032561 guanyl ribonucleotide binding 6/131 400/18639 0.015 2.13423664122137 0.063336745114181 0.318258198282874 GO:0005131 growth hormone receptor binding 1/131 10/18639 0.1 14.2282442748092 0.0681169744970964 0.318258198282874 GO:0005381 iron ion transmembrane transporter activity 1/131 10/18639 0.1 14.2282442748092 0.0681169744970964 0.318258198282874 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/131 10/18639 0.1 14.2282442748092 0.0681169744970964 0.318258198282874 GO:0031996 thioesterase binding 1/131 10/18639 0.1 14.2282442748092 0.0681169744970964 0.318258198282874 GO:0016779 nucleotidyltransferase activity 3/131 136/18639 0.0220588235294118 3.13858329591379 0.0710380536142718 0.318258198282874 GO:0051020 GTPase binding 5/131 315/18639 0.0158730158730159 2.25845147219193 0.0716520234227969 0.318258198282874 GO:0004857 enzyme inhibitor activity 6/131 416/18639 0.0144230769230769 2.05215061655901 0.0734839316594629 0.318258198282874 GO:0000099 sulfur amino acid transmembrane transporter activity 1/131 11/18639 0.0909090909090909 12.9347675225538 0.0746700195527019 0.318258198282874 GO:0005114 type II transforming growth factor beta receptor binding 1/131 11/18639 0.0909090909090909 12.9347675225538 0.0746700195527019 0.318258198282874 GO:0005536 D-glucose binding 1/131 11/18639 0.0909090909090909 12.9347675225538 0.0746700195527019 0.318258198282874 GO:0008526 phosphatidylinositol transfer activity 1/131 11/18639 0.0909090909090909 12.9347675225538 0.0746700195527019 0.318258198282874 GO:0015173 aromatic amino acid transmembrane transporter activity 1/131 11/18639 0.0909090909090909 12.9347675225538 0.0746700195527019 0.318258198282874 GO:0019206 nucleoside kinase activity 1/131 11/18639 0.0909090909090909 12.9347675225538 0.0746700195527019 0.318258198282874 GO:0070697 activin receptor binding 1/131 11/18639 0.0909090909090909 12.9347675225538 0.0746700195527019 0.318258198282874 GO:0140031 phosphorylation-dependent protein binding 1/131 11/18639 0.0909090909090909 12.9347675225538 0.0746700195527019 0.318258198282874 GO:0070851 growth factor receptor binding 3/131 139/18639 0.0215827338129496 3.07084408808831 0.0747654180093101 0.318258198282874 GO:0004713 protein tyrosine kinase activity 3/131 140/18639 0.0214285714285714 3.04890948745911 0.0760269305675018 0.319313108383507 GO:0005078 MAP-kinase scaffold activity 1/131 12/18639 0.0833333333333333 11.8568702290076 0.0811773325996524 0.323681769226462 GO:0015368 calcium:monoatomic cation antiporter activity 1/131 12/18639 0.0833333333333333 11.8568702290076 0.0811773325996524 0.323681769226462 GO:0035259 nuclear glucocorticoid receptor binding 1/131 12/18639 0.0833333333333333 11.8568702290076 0.0811773325996524 0.323681769226462 GO:0097677 STAT family protein binding 1/131 12/18639 0.0833333333333333 11.8568702290076 0.0811773325996524 0.323681769226462 GO:0045296 cadherin binding 5/131 334/18639 0.0149700598802395 2.12997668784568 0.0868725006619178 0.336662897083173 GO:0005172 vascular endothelial growth factor receptor binding 1/131 13/18639 0.0769230769230769 10.9448032883147 0.0876392303518102 0.336662897083173 GO:0005542 folic acid binding 1/131 13/18639 0.0769230769230769 10.9448032883147 0.0876392303518102 0.336662897083173 GO:0003779 actin binding 6/131 443/18639 0.0135440180586907 1.92707597401478 0.092601881295799 0.344507542025133 GO:0003774 cytoskeletal motor activity 3/131 153/18639 0.0196078431372549 2.78985181859003 0.0932615835986943 0.344507542025133 GO:0005161 platelet-derived growth factor receptor binding 1/131 14/18639 0.0714285714285714 10.1630316248637 0.0940560273465443 0.344507542025133 GO:0016530 metallochaperone activity 1/131 14/18639 0.0714285714285714 10.1630316248637 0.0940560273465443 0.344507542025133 GO:0048029 monosaccharide binding 2/131 74/18639 0.027027027027027 3.8454714256241 0.095530705044947 0.345887035507567 GO:0031386 protein tag activity 1/131 15/18639 0.0666666666666667 9.48549618320611 0.10042803595957 0.355447543002973 GO:0141047 molecular tag activity 1/131 15/18639 0.0666666666666667 9.48549618320611 0.10042803595957 0.355447543002973 GO:0005159 insulin-like growth factor receptor binding 1/131 16/18639 0.0625 8.89265267175572 0.106755566419691 0.357337516127442 GO:0070411 I-SMAD binding 1/131 16/18639 0.0625 8.89265267175572 0.106755566419691 0.357337516127442 GO:0097027 ubiquitin-protein transferase activator activity 1/131 16/18639 0.0625 8.89265267175572 0.106755566419691 0.357337516127442 GO:0001618 virus receptor activity 2/131 81/18639 0.0246913580246914 3.51314673452078 0.111095621886158 0.357337516127442 GO:0030971 receptor tyrosine kinase binding 2/131 81/18639 0.0246913580246914 3.51314673452078 0.111095621886158 0.357337516127442 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/131 17/18639 0.0588235294117647 8.3695554557701 0.11303892682344 0.357337516127442 GO:0036041 long-chain fatty acid binding 1/131 17/18639 0.0588235294117647 8.3695554557701 0.11303892682344 0.357337516127442 GO:0046965 nuclear retinoid X receptor binding 1/131 17/18639 0.0588235294117647 8.3695554557701 0.11303892682344 0.357337516127442 GO:0048038 quinone binding 1/131 17/18639 0.0588235294117647 8.3695554557701 0.11303892682344 0.357337516127442 GO:0140272 exogenous protein binding 2/131 82/18639 0.024390243902439 3.47030348166077 0.113370938746291 0.357337516127442 GO:0016874 ligase activity 3/131 167/18639 0.0179640718562874 2.55597202541482 0.113440481310299 0.357337516127442 GO:0008525 phosphatidylcholine transporter activity 1/131 18/18639 0.0555555555555556 7.90458015267176 0.11927842314962 0.361275993193562 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/131 18/18639 0.0555555555555556 7.90458015267176 0.11927842314962 0.361275993193562 GO:0035615 clathrin adaptor activity 1/131 18/18639 0.0555555555555556 7.90458015267176 0.11927842314962 0.361275993193562 GO:1901611 phosphatidylglycerol binding 1/131 18/18639 0.0555555555555556 7.90458015267176 0.11927842314962 0.361275993193562 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 4/131 268/18639 0.0149253731343284 2.12361854847898 0.120451143182043 0.361353429546129 GO:0003823 antigen binding 3/131 174/18639 0.0172413793103448 2.45314556462227 0.124102408024618 0.368794891771271 GO:0140036 ubiquitin-modified protein reader activity 1/131 19/18639 0.0526315789473684 7.48854961832061 0.125474359273749 0.369387132441411 GO:0016004 phospholipase activator activity 1/131 20/18639 0.05 7.11412213740458 0.131627036982403 0.375437179466411 GO:0001217 DNA-binding transcription repressor activity 4/131 278/18639 0.0143884892086331 2.04722939205887 0.132594551851523 0.375437179466411 GO:0030246 carbohydrate binding 4/131 280/18639 0.0142857142857143 2.03260632497274 0.13508230913098 0.375437179466411 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/131 21/18639 0.0476190476190476 6.77535441657579 0.137736755987468 0.375437179466411 GO:0070182 DNA polymerase binding 1/131 21/18639 0.0476190476190476 6.77535441657579 0.137736755987468 0.375437179466411 GO:0140312 cargo adaptor activity 1/131 21/18639 0.0476190476190476 6.77535441657579 0.137736755987468 0.375437179466411 GO:0031267 small GTPase binding 4/131 283/18639 0.0141342756183746 2.01105926145713 0.138849741002998 0.375437179466411 GO:0140035 ubiquitin-like protein reader activity 1/131 22/18639 0.0454545454545455 6.46738376127689 0.143803813940291 0.375437179466411 GO:0019902 phosphatase binding 3/131 190/18639 0.0157894736842105 2.24656488549618 0.149745121599281 0.375437179466411 GO:0003887 DNA-directed DNA polymerase activity 1/131 23/18639 0.0434782608695652 6.1861931629605 0.149828506445733 0.375437179466411 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/131 23/18639 0.0434782608695652 6.1861931629605 0.149828506445733 0.375437179466411 GO:0017134 fibroblast growth factor binding 1/131 23/18639 0.0434782608695652 6.1861931629605 0.149828506445733 0.375437179466411 GO:0043274 phospholipase binding 1/131 23/18639 0.0434782608695652 6.1861931629605 0.149828506445733 0.375437179466411 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/131 23/18639 0.0434782608695652 6.1861931629605 0.149828506445733 0.375437179466411 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/131 23/18639 0.0434782608695652 6.1861931629605 0.149828506445733 0.375437179466411 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/131 24/18639 0.0416666666666667 5.92843511450382 0.155811127076137 0.375437179466411 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/131 24/18639 0.0416666666666667 5.92843511450382 0.155811127076137 0.375437179466411 GO:0015149 hexose transmembrane transporter activity 1/131 24/18639 0.0416666666666667 5.92843511450382 0.155811127076137 0.375437179466411 GO:0030552 cAMP binding 1/131 24/18639 0.0416666666666667 5.92843511450382 0.155811127076137 0.375437179466411 GO:0035035 histone acetyltransferase binding 1/131 24/18639 0.0416666666666667 5.92843511450382 0.155811127076137 0.375437179466411 GO:0055056 D-glucose transmembrane transporter activity 1/131 24/18639 0.0416666666666667 5.92843511450382 0.155811127076137 0.375437179466411 GO:0060229 lipase activator activity 1/131 24/18639 0.0416666666666667 5.92843511450382 0.155811127076137 0.375437179466411 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/131 24/18639 0.0416666666666667 5.92843511450382 0.155811127076137 0.375437179466411 GO:0043130 ubiquitin binding 2/131 100/18639 0.02 2.84564885496183 0.156134192095555 0.375437179466411 GO:0003707 nuclear steroid receptor activity 1/131 25/18639 0.04 5.69129770992366 0.161751967385191 0.379551950844633 GO:0042974 nuclear retinoic acid receptor binding 1/131 25/18639 0.04 5.69129770992366 0.161751967385191 0.379551950844633 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/131 26/18639 0.0384615384615385 5.47240164415737 0.167651316921697 0.379551950844633 GO:0005112 Notch binding 1/131 26/18639 0.0384615384615385 5.47240164415737 0.167651316921697 0.379551950844633 GO:0015145 monosaccharide transmembrane transporter activity 1/131 26/18639 0.0384615384615385 5.47240164415737 0.167651316921697 0.379551950844633 GO:0050681 nuclear androgen receptor binding 1/131 26/18639 0.0384615384615385 5.47240164415737 0.167651316921697 0.379551950844633 GO:0070412 R-SMAD binding 1/131 26/18639 0.0384615384615385 5.47240164415737 0.167651316921697 0.379551950844633 GO:0120014 phospholipid transfer activity 1/131 26/18639 0.0384615384615385 5.47240164415737 0.167651316921697 0.379551950844633 GO:0003714 transcription corepressor activity 3/131 204/18639 0.0147058823529412 2.09238886394252 0.173449692585354 0.379551950844633 GO:0001671 ATPase activator activity 1/131 27/18639 0.037037037037037 5.26972010178117 0.173509463243261 0.379551950844633 GO:0008320 protein transmembrane transporter activity 1/131 27/18639 0.037037037037037 5.26972010178117 0.173509463243261 0.379551950844633 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/131 27/18639 0.037037037037037 5.26972010178117 0.173509463243261 0.379551950844633 GO:0035255 ionotropic glutamate receptor binding 1/131 27/18639 0.037037037037037 5.26972010178117 0.173509463243261 0.379551950844633 GO:0005516 calmodulin binding 3/131 207/18639 0.0144927536231884 2.0620643876535 0.178663144806803 0.383602205777478 GO:0051119 sugar transmembrane transporter activity 1/131 28/18639 0.0357142857142857 5.08151581243184 0.179326691929868 0.383602205777478 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/131 28/18639 0.0357142857142857 5.08151581243184 0.179326691929868 0.383602205777478 GO:1902936 phosphatidylinositol bisphosphate binding 2/131 111/18639 0.018018018018018 2.56364761708273 0.18356257492199 0.383602205777478 GO:0003785 actin monomer binding 1/131 29/18639 0.0344827586206897 4.90629112924454 0.185103286597386 0.383602205777478 GO:0004181 metallocarboxypeptidase activity 1/131 29/18639 0.0344827586206897 4.90629112924454 0.185103286597386 0.383602205777478 GO:0043236 laminin binding 1/131 29/18639 0.0344827586206897 4.90629112924454 0.185103286597386 0.383602205777478 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/131 29/18639 0.0344827586206897 4.90629112924454 0.185103286597386 0.383602205777478 GO:0031210 phosphatidylcholine binding 1/131 30/18639 0.0333333333333333 4.74274809160305 0.190839528910967 0.38534904876253 GO:0033612 receptor serine/threonine kinase binding 1/131 30/18639 0.0333333333333333 4.74274809160305 0.190839528910967 0.38534904876253 GO:0051721 protein phosphatase 2A binding 1/131 30/18639 0.0333333333333333 4.74274809160305 0.190839528910967 0.38534904876253 GO:0070566 adenylyltransferase activity 1/131 30/18639 0.0333333333333333 4.74274809160305 0.190839528910967 0.38534904876253 GO:0017124 SH3 domain binding 2/131 115/18639 0.0173913043478261 2.4744772651842 0.193707264272029 0.388648332775091 GO:1990782 protein tyrosine kinase binding 2/131 117/18639 0.0170940170940171 2.43217850851439 0.198807029168685 0.39635578600086 GO:0022884 macromolecule transmembrane transporter activity 1/131 32/18639 0.03125 4.44632633587786 0.202192073463127 0.398065644630531 GO:0051059 NF-kappaB binding 1/131 32/18639 0.03125 4.44632633587786 0.202192073463127 0.398065644630531 GO:0032182 ubiquitin-like protein binding 2/131 120/18639 0.0166666666666667 2.37137404580153 0.206486775375526 0.401593943314754 GO:0030296 protein tyrosine kinase activator activity 1/131 33/18639 0.0303030303030303 4.31158917418459 0.207808929397793 0.401593943314754 GO:0140416 transcription regulator inhibitor activity 1/131 33/18639 0.0303030303030303 4.31158917418459 0.207808929397793 0.401593943314754 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/131 122/18639 0.0163934426229508 2.33249906144412 0.211624581493723 0.402495570209671 GO:0030332 cyclin binding 1/131 34/18639 0.0294117647058824 4.18477772788505 0.213386540396873 0.402495570209671 GO:0051427 hormone receptor binding 1/131 34/18639 0.0294117647058824 4.18477772788505 0.213386540396873 0.402495570209671 GO:0090482 vitamin transmembrane transporter activity 1/131 34/18639 0.0294117647058824 4.18477772788505 0.213386540396873 0.402495570209671 GO:0034061 DNA polymerase activity 1/131 35/18639 0.0285714285714286 4.06521264994547 0.218925178569839 0.408055806210054 GO:0140566 histone reader activity 1/131 35/18639 0.0285714285714286 4.06521264994547 0.218925178569839 0.408055806210054 GO:0023023 MHC protein complex binding 1/131 37/18639 0.027027027027027 3.8454714256241 0.229886615527189 0.42280350607706 GO:0030551 cyclic nucleotide binding 1/131 37/18639 0.027027027027027 3.8454714256241 0.229886615527189 0.42280350607706 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 4/131 349/18639 0.0114613180515759 1.63074432949102 0.230864136651601 0.42280350607706 GO:0043531 ADP binding 1/131 38/18639 0.0263157894736842 3.74427480916031 0.23530994922066 0.428454531817964 GO:0015144 carbohydrate transmembrane transporter activity 1/131 40/18639 0.025 3.55706106870229 0.246043170535195 0.430306404135465 GO:0050997 quaternary ammonium group binding 1/131 40/18639 0.025 3.55706106870229 0.246043170535195 0.430306404135465 GO:0061791 GTPase motor activity 1/131 40/18639 0.025 3.55706106870229 0.246043170535195 0.430306404135465 GO:1990606 membrane scission GTPase motor activity 1/131 40/18639 0.025 3.55706106870229 0.246043170535195 0.430306404135465 GO:0016922 nuclear receptor binding 2/131 137/18639 0.0145985401459854 2.07711595252688 0.25047455206719 0.430306404135465 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/131 41/18639 0.024390243902439 3.47030348166077 0.251353582098176 0.430306404135465 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/131 41/18639 0.024390243902439 3.47030348166077 0.251353582098176 0.430306404135465 GO:0042169 SH2 domain binding 1/131 41/18639 0.024390243902439 3.47030348166077 0.251353582098176 0.430306404135465 GO:0042287 MHC protein binding 1/131 41/18639 0.024390243902439 3.47030348166077 0.251353582098176 0.430306404135465 GO:0140318 protein transporter activity 1/131 41/18639 0.024390243902439 3.47030348166077 0.251353582098176 0.430306404135465 GO:0140828 metal cation:monoatomic cation antiporter activity 1/131 41/18639 0.024390243902439 3.47030348166077 0.251353582098176 0.430306404135465 GO:0030295 protein kinase activator activity 2/131 139/18639 0.0143884892086331 2.04722939205887 0.255680009687955 0.432285910563442 GO:0140767 enzyme-substrate adaptor activity 2/131 139/18639 0.0143884892086331 2.04722939205887 0.255680009687955 0.432285910563442 GO:0035198 miRNA binding 1/131 42/18639 0.0238095238095238 3.3876772082879 0.256626873890043 0.432285910563442 GO:0019205 nucleobase-containing compound kinase activity 1/131 44/18639 0.0227272727272727 3.23369188063845 0.267063126328526 0.445105210547544 GO:0043014 alpha-tubulin binding 1/131 44/18639 0.0227272727272727 3.23369188063845 0.267063126328526 0.445105210547544 GO:0019903 protein phosphatase binding 2/131 144/18639 0.0138888888888889 1.97614503816794 0.268701465060149 0.445478744704983 GO:0005543 phospholipid binding 5/131 497/18639 0.0100603621730382 1.43141290491038 0.271569837270442 0.446621760113304 GO:0046915 transition metal ion transmembrane transporter activity 1/131 45/18639 0.0222222222222222 3.1618320610687 0.27222659664049 0.446621760113304 GO:0004180 carboxypeptidase activity 1/131 46/18639 0.0217391304347826 3.09309658148025 0.27735396653616 0.450342780715931 GO:0030276 clathrin binding 1/131 46/18639 0.0217391304347826 3.09309658148025 0.27735396653616 0.450342780715931 GO:0019209 kinase activator activity 2/131 148/18639 0.0135135135135135 1.92273571281205 0.27911801177723 0.45088294210168 GO:0005504 fatty acid binding 1/131 47/18639 0.0212765957446809 3.02728601591684 0.282445486483655 0.451626031687062 GO:0140938 histone H3 methyltransferase activity 1/131 47/18639 0.0212765957446809 3.02728601591684 0.282445486483655 0.451626031687062 GO:0015631 tubulin binding 4/131 385/18639 0.0103896103896104 1.47825914543472 0.286267728671614 0.452814713232048 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/131 48/18639 0.0208333333333333 2.96421755725191 0.287501405226697 0.452814713232048 GO:0140693 molecular condensate scaffold activity 1/131 48/18639 0.0208333333333333 2.96421755725191 0.287501405226697 0.452814713232048 GO:0001222 transcription corepressor binding 1/131 49/18639 0.0204081632653061 2.90372332138962 0.292521969796398 0.453913401408203 GO:0016763 pentosyltransferase activity 1/131 49/18639 0.0204081632653061 2.90372332138962 0.292521969796398 0.453913401408203 GO:0060590 ATPase regulator activity 1/131 49/18639 0.0204081632653061 2.90372332138962 0.292521969796398 0.453913401408203 GO:0048020 CCR chemokine receptor binding 1/131 50/18639 0.02 2.84564885496183 0.297507425522954 0.459386465881031 GO:0008017 microtubule binding 3/131 276/18639 0.0108695652173913 1.54654829074013 0.306834839980093 0.471477924847459 GO:0004864 protein phosphatase inhibitor activity 1/131 53/18639 0.0188679245283019 2.68457439147343 0.312255567675502 0.475171516027937 GO:0051018 protein kinase A binding 1/131 53/18639 0.0188679245283019 2.68457439147343 0.312255567675502 0.475171516027937 GO:0008083 growth factor activity 2/131 162/18639 0.0123456790123457 1.75657336726039 0.315455467475189 0.477733039685983 GO:0019212 phosphatase inhibitor activity 1/131 56/18639 0.0178571428571429 2.54075790621592 0.326696401264096 0.492389312910002 GO:0016504 peptidase activator activity 1/131 57/18639 0.0175438596491228 2.49618320610687 0.331442823878013 0.497164235817019 GO:0061980 regulatory RNA binding 1/131 58/18639 0.0172413793103448 2.45314556462227 0.33615604043554 0.501698264783907 GO:0004879 nuclear receptor activity 1/131 59/18639 0.0169491525423729 2.41156682623884 0.340836281472242 0.501698264783907 GO:0031593 polyubiquitin modification-dependent protein binding 1/131 59/18639 0.0169491525423729 2.41156682623884 0.340836281472242 0.501698264783907 GO:0036002 pre-mRNA binding 1/131 59/18639 0.0169491525423729 2.41156682623884 0.340836281472242 0.501698264783907 GO:0140030 modification-dependent protein binding 2/131 173/18639 0.0115606936416185 1.64488373119181 0.343733318850047 0.503609281105882 GO:0098531 ligand-modulated transcription factor activity 1/131 60/18639 0.0166666666666667 2.37137404580153 0.345483775935489 0.503830506572588 GO:0015179 L-amino acid transmembrane transporter activity 1/131 62/18639 0.0161290322580645 2.29487810884019 0.354681433055233 0.514860144757596 GO:0005507 copper ion binding 1/131 63/18639 0.0158730158730159 2.25845147219193 0.359232045762869 0.516703627467141 GO:1901682 sulfur compound transmembrane transporter activity 1/131 63/18639 0.0158730158730159 2.25845147219193 0.359232045762869 0.516703627467141 GO:0120013 lipid transfer activity 1/131 65/18639 0.0153846153846154 2.18896065766295 0.368237952996468 0.527249796335852 GO:0008235 metalloexopeptidase activity 1/131 66/18639 0.0151515151515152 2.1557945870923 0.3726936883339 0.531214985634292 GO:0042054 histone methyltransferase activity 1/131 67/18639 0.0149253731343284 2.12361854847898 0.377118236162913 0.531753190839262 GO:0050840 extracellular matrix binding 1/131 67/18639 0.0149253731343284 2.12361854847898 0.377118236162913 0.531753190839262 GO:0031406 carboxylic acid binding 2/131 187/18639 0.0106951871657754 1.52173735559456 0.37916928114717 0.531753190839262 GO:0005548 phospholipid transporter activity 1/131 68/18639 0.0147058823529412 2.09238886394252 0.381511813110074 0.531753190839262 GO:1990841 promoter-specific chromatin binding 1/131 68/18639 0.0147058823529412 2.09238886394252 0.381511813110074 0.531753190839262 GO:0043177 organic acid binding 2/131 189/18639 0.0105820105820106 1.50563431479462 0.384169790472777 0.533099048453414 GO:0016279 protein-lysine N-methyltransferase activity 1/131 69/18639 0.0144927536231884 2.0620643876535 0.385874634308855 0.533116271084603 GO:0016278 lysine N-methyltransferase activity 1/131 70/18639 0.0142857142857143 2.03260632497274 0.390206913409854 0.534413816191756 GO:0097110 scaffold protein binding 1/131 70/18639 0.0142857142857143 2.03260632497274 0.390206913409854 0.534413816191756 GO:0005518 collagen binding 1/131 72/18639 0.0138888888888889 1.97614503816794 0.39878069256726 0.541447923097788 GO:0042379 chemokine receptor binding 1/131 72/18639 0.0138888888888889 1.97614503816794 0.39878069256726 0.541447923097788 GO:0043539 protein serine/threonine kinase activator activity 1/131 73/18639 0.0136986301369863 1.94907455819304 0.40302261260139 0.54485889686454 GO:0033293 monocarboxylic acid binding 1/131 79/18639 0.0126582278481013 1.80104357908977 0.427857562176369 0.575962102929728 GO:0000049 tRNA binding 1/131 80/18639 0.0125 1.77853053435115 0.431895852012301 0.578924227165425 GO:0015101 organic cation transmembrane transporter activity 1/131 81/18639 0.0123456790123457 1.75657336726039 0.435905854888878 0.581823492754223 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 4/131 484/18639 0.00826446280991736 1.1758879565958 0.443455464140992 0.589402832086129 GO:0051117 ATPase binding 1/131 84/18639 0.0119047619047619 1.69383860414395 0.447768101267882 0.592162158543642 GO:0140297 DNA-binding transcription factor binding 4/131 488/18639 0.00819672131147541 1.16624953072206 0.449698049897531 0.592162158543642 GO:0001216 DNA-binding transcription activator activity 4/131 491/18639 0.00814663951120163 1.15912376984189 0.454366071656981 0.592162158543642 GO:0141003 histone H2AX kinase activity 3/131 354/18639 0.00847457627118644 1.20578341311942 0.454738510663829 0.592162158543642 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/131 86/18639 0.0116279069767442 1.65444700869874 0.455538399577582 0.592162158543642 GO:0008081 phosphoric diester hydrolase activity 1/131 87/18639 0.0114942528735632 1.63543037641485 0.459382762734772 0.592162158543642 GO:0140996 histone H3 kinase activity 3/131 357/18639 0.00840336134453781 1.19565077939573 0.460223579846098 0.592162158543642 GO:0003712 transcription coregulator activity 4/131 495/18639 0.00808080808080808 1.14975711311589 0.460570567756166 0.592162158543642 GO:0035173 histone kinase activity 3/131 360/18639 0.00833333333333333 1.18568702290076 0.46568552927848 0.596304641149273 GO:0072341 modified amino acid binding 1/131 91/18639 0.010989010989011 1.56354332690211 0.474492694933675 0.605122262769666 GO:0008276 protein methyltransferase activity 1/131 95/18639 0.0105263157894737 1.49770992366412 0.489183447597722 0.621341879005171 GO:0008170 N-methyltransferase activity 1/131 98/18639 0.0102040816326531 1.45186166069481 0.499933380633019 0.632445842969481 GO:0008238 exopeptidase activity 1/131 102/18639 0.00980392156862745 1.39492590929502 0.513918151721619 0.644957042997251 GO:0015171 amino acid transmembrane transporter activity 1/131 102/18639 0.00980392156862745 1.39492590929502 0.513918151721619 0.644957042997251 GO:0042393 histone binding 2/131 247/18639 0.00809716599190283 1.15208455666471 0.520133994476466 0.650167493095582 GO:0042277 peptide binding 2/131 249/18639 0.00803212851405622 1.14283086544652 0.524463800210414 0.650417704985355 GO:0140104 molecular carrier activity 2/131 249/18639 0.00803212851405622 1.14283086544652 0.524463800210414 0.650417704985355 GO:0008013 beta-catenin binding 1/131 106/18639 0.00943396226415094 1.34228719573671 0.527514729682856 0.651635842549411 GO:0019888 protein phosphatase regulator activity 1/131 107/18639 0.00934579439252336 1.32974245558964 0.530854478801269 0.653199846962499 GO:0019887 protein kinase regulator activity 2/131 255/18639 0.00784313725490196 1.11594072743601 0.537296534524989 0.658554118192107 GO:0005200 structural constituent of cytoskeleton 1/131 112/18639 0.00892857142857143 1.27037895310796 0.547205049580566 0.668099188441389 GO:0019208 phosphatase regulator activity 1/131 117/18639 0.00854700854700855 1.21608925425719 0.562989972433063 0.684717534040212 GO:0008514 organic anion transmembrane transporter activity 2/131 269/18639 0.00743494423791822 1.05786202786685 0.566312199666548 0.686109011134472 GO:0042826 histone deacetylase binding 1/131 127/18639 0.0078740157480315 1.12033419486686 0.592939905368507 0.715617127168888 GO:0019207 kinase regulator activity 2/131 287/18639 0.00696864111498258 0.991515280474506 0.601679754109459 0.723393597498013 GO:0005179 hormone activity 1/131 132/18639 0.00757575757575758 1.07789729354615 0.607141798440216 0.727185043759194 GO:0051087 protein-folding chaperone binding 1/131 134/18639 0.00746268656716418 1.06180927423949 0.612683881120212 0.731043267245707 GO:0015297 antiporter activity 1/131 135/18639 0.00740740740740741 1.05394402035623 0.615425756914497 0.731543824256855 GO:0019838 growth factor binding 1/131 136/18639 0.00735294117647059 1.04619443197126 0.61814836963846 0.731908310507404 GO:0001664 G protein-coupled receptor binding 2/131 297/18639 0.00673400673400673 0.958130927596576 0.620379425096752 0.731908310507404 GO:0015085 calcium ion transmembrane transporter activity 1/131 147/18639 0.00680272108843537 0.967907773796541 0.646863500325427 0.755080422797122 GO:0019842 vitamin binding 1/131 150/18639 0.00666666666666667 0.948549618320611 0.654315869425124 0.755080422797122 GO:0000510 H3-H4 histone complex chaperone activity 1/131 151/18639 0.00662251655629139 0.942267832768819 0.656765143107059 0.755080422797122 GO:0140584 chromatin extrusion motor activity 1/131 151/18639 0.00662251655629139 0.942267832768819 0.656765143107059 0.755080422797122 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 1/131 151/18639 0.00662251655629139 0.942267832768819 0.656765143107059 0.755080422797122 GO:0140849 ATP-dependent H2AZ histone chaperone activity 1/131 151/18639 0.00662251655629139 0.942267832768819 0.656765143107059 0.755080422797122 GO:0015616 DNA translocase activity 1/131 152/18639 0.00657894736842105 0.936068702290076 0.659197194505424 0.755080422797122 GO:0140674 ATP-dependent histone chaperone activity 1/131 152/18639 0.00657894736842105 0.936068702290076 0.659197194505424 0.755080422797122 GO:0061775 cohesin loader activity 1/131 153/18639 0.0065359477124183 0.929950606196677 0.661612143795184 0.755100816287982 GO:0140375 immune receptor activity 1/131 156/18639 0.00641025641025641 0.912066940692895 0.668755568315087 0.760498209455785 GO:0140658 ATP-dependent chromatin remodeler activity 1/131 158/18639 0.00632911392405063 0.900521789544884 0.673434506810005 0.763064279299107 GO:0003689 DNA clamp loader activity 1/131 160/18639 0.00625 0.889265267175573 0.678047851168932 0.764772577741961 GO:0005178 integrin binding 1/131 161/18639 0.0062111801242236 0.883741880422929 0.680330211226125 0.764772577741961 GO:0140097 catalytic activity, acting on DNA 2/131 336/18639 0.00595238095238095 0.846919302071974 0.686899001034599 0.764772577741961 GO:0015081 sodium ion transmembrane transporter activity 1/131 164/18639 0.00609756097560976 0.867575870415193 0.68708139524119 0.764772577741961 GO:0140713 histone chaperone activity 1/131 164/18639 0.00609756097560976 0.867575870415193 0.68708139524119 0.764772577741961 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/131 167/18639 0.00598802395209581 0.851990675138273 0.69369106490498 0.767831461306669 GO:0005261 monoatomic cation channel activity 2/131 341/18639 0.00586510263929619 0.834501130487341 0.694704655467938 0.767831461306669 GO:0008201 heparin binding 1/131 172/18639 0.00581395348837209 0.82722350434937 0.704400673167731 0.775825916251173 GO:0061630 ubiquitin protein ligase activity 2/131 353/18639 0.0056657223796034 0.806132820102502 0.712789176605454 0.781246555190486 GO:0043021 ribonucleoprotein complex binding 1/131 177/18639 0.00564971751412429 0.80385560874628 0.714738595761855 0.781246555190486 GO:0005319 lipid transporter activity 1/131 178/18639 0.00561797752808989 0.799339566000515 0.716762712539842 0.781246555190486 GO:0008237 metallopeptidase activity 1/131 184/18639 0.00543478260869565 0.773274145370063 0.728611550313874 0.791422890858173 GO:0046943 carboxylic acid transmembrane transporter activity 1/131 188/18639 0.00531914893617021 0.756821503979211 0.736236142993413 0.792425910399596 GO:0140597 protein carrier chaperone 1/131 188/18639 0.00531914893617021 0.756821503979211 0.736236142993413 0.792425910399596 GO:0005342 organic acid transmembrane transporter activity 1/131 189/18639 0.00529100529100529 0.75281715739731 0.738108836357884 0.792425910399596 GO:0061659 ubiquitin-like protein ligase activity 2/131 372/18639 0.00537634408602151 0.764959369613396 0.739597516372957 0.792425910399596 GO:0008168 methyltransferase activity 1/131 204/18639 0.00490196078431373 0.697462954647508 0.764666342843323 0.816508128798802 GO:0008094 ATP-dependent activity, acting on DNA 1/131 210/18639 0.00476190476190476 0.677535441657579 0.774524839159506 0.824240960592042 GO:0016741 transferase activity, transferring one-carbon groups 1/131 215/18639 0.00465116279069767 0.661778803479496 0.782426356718668 0.829846135913739 GO:0016887 ATP hydrolysis activity 2/131 417/18639 0.00479616306954436 0.682409797352957 0.794732921883689 0.840070034877054 GO:0061134 peptidase regulator activity 1/131 226/18639 0.00442477876106195 0.629568330743768 0.798855528740344 0.841603650679626 GO:0005125 cytokine activity 1/131 234/18639 0.00427350427350427 0.608044627128597 0.81002494542884 0.850526192700282 GO:0005539 glycosaminoglycan binding 1/131 242/18639 0.00413223140495868 0.587943978297899 0.82057860432062 0.855563599938162 GO:0005216 monoatomic ion channel activity 2/131 448/18639 0.00446428571428571 0.63518947655398 0.826511359164628 0.855563599938162 GO:0033218 amide binding 1/131 247/18639 0.00404858299595142 0.576042278332355 0.826877002847334 0.855563599938162 GO:0004842 ubiquitin-protein transferase activity 2/131 449/18639 0.0044543429844098 0.633774800659651 0.82745941607292 0.855563599938162 GO:0046873 metal ion transmembrane transporter activity 2/131 450/18639 0.00444444444444444 0.63236641221374 0.828402850733776 0.855563599938162 GO:0003713 transcription coactivator activity 1/131 256/18639 0.00390625 0.555790791984733 0.83766616601762 0.862303406194609 GO:0003730 mRNA 3'-UTR binding 1/131 262/18639 0.00381679389312977 0.543062758580502 0.844485481746248 0.866491618078398 GO:0016757 glycosyltransferase activity 1/131 267/18639 0.00374531835205993 0.532893044000343 0.849950511836196 0.869267568923383 GO:0019787 ubiquitin-like protein transferase activity 2/131 479/18639 0.00417536534446764 0.594081180576583 0.853829888894462 0.870409110038044 GO:1901681 sulfur compound binding 1/131 275/18639 0.00363636363636364 0.517390700902151 0.858300794112154 0.872144355307511 GO:0016755 aminoacyltransferase activity 2/131 496/18639 0.00403225806451613 0.573719527210047 0.867103000958985 0.878255451132091 GO:0015291 secondary active transmembrane transporter activity 1/131 287/18639 0.00348432055749129 0.495757640237253 0.869969158877489 0.878334246943619 GO:0045182 translation regulator activity 1/131 356/18639 0.00280898876404494 0.399669783000257 0.920754620089488 0.926638036192296 GO:0042578 phosphoric ester hydrolase activity 1/131 363/18639 0.00275482093663912 0.391962652198599 0.924645443827734 0.927590174540561 GO:0046982 protein heterodimerization activity 1/131 369/18639 0.002710027100271 0.385589275740086 0.927829139869643 0.927829139869643