category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	40/166	222/9376	10.1769239118637	RPL37A/RPS26/RPL36A/RPLP2/RPL21/RPL38/FAU/RPL27A/RPL41/RPL37/UBA52/RPS10/RPS29/RPL35/RPS8/RPS15/RPS21/RPS19/RPL36/RPL17/RPL23A/RPL34/RPL26/RPLP1/RPL31/RPL36AL/RPS25/RPL28/RPL27/RPL35A/RPS23/RPS27/RPS2/RPS12/RPS16/RPL32/RPS18/RPL30/RPL29/MRPL23	18.5771048027744
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	40/166	238/9376	9.49276095980561	RPL37A/RPS26/RPL36A/RPLP2/RPL21/RPL38/FAU/RPL27A/RPL41/RPL37/UBA52/RPS10/RPS29/RPL35/RPS8/RPS15/RPS21/RPS19/RPL36/RPL17/RPL23A/RPL34/RPL26/RPLP1/RPL31/RPL36AL/RPS25/RPL28/RPL27/RPL35A/RPS23/RPS27/HBEGF/RPS2/RPS12/RPS16/RPL32/RPS18/RPL30/RPL29	17.8164703421811
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/166	138/9376	11.0508119434259	MT-ND3/MT-ND5/MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/MT-ND1/COX7B/UQCR10/MT-ATP8/ATP5MF/NDUFA13/COX6A1/UQCR11/ATP5F1E/UQCRB/COX7A2/COX17/NDUFA4/COX5B/COX8A/NDUFB3/NDUFB4/NDUFB7	15.9684064565527
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	30/166	235/9376	7.21045885670341	MT-ND3/MT-ND5/MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/MT-ND1/COX7B/UQCR10/MT-ATP8/ATP5MF/NDUFA13/PRKAG2/MGLL/COX6A1/UQCR11/ATP5F1E/UQCRB/COX7A2/COX17/NDUFA4/COX5B/GNAS/COX8A/NDUFB3/NDUFB4/NDUFB7	12.9440634398118
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	27/166	205/9376	7.43908316191596	MT-ND3/MT-ND5/MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/CYBA/MT-ND1/COX7B/UQCR10/MT-ATP8/NDUFA13/COX6A1/UQCR11/ATP5F1E/UQCRB/COX7A2/NDUFA4/COX5B/COX8A/SLC25A6/NDUFB3/NDUFB4/NDUFB7	12.5141825243479
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	30/166	268/9376	6.32260384822874	MT-ND3/MT-ND5/MT-CYB/COX7C/UBA52/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/MT-ND1/EIF2AK3/COX7B/UQCR10/MT-ATP8/NDUFA13/COX6A1/UQCR11/ATP5F1E/UQCRB/COX7A2/CALM1/NDUFA4/COX5B/GNAS/COX8A/SLC25A6/NDUFB3/NDUFB4/NDUFB7	11.8683377440893
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	27/166	227/9376	6.71811474974789	MT-ND3/MT-ND5/MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/CYBA/MT-ND1/COX7B/UQCR10/MT-ATP8/NDUFA13/COX6A1/UQCR11/ATP5F1E/UQCRB/COX7A2/NDUFA4/COX5B/COX8A/SLC25A6/NDUFB3/NDUFB4/NDUFB7	11.7081653814043
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	29/166	275/9376	5.95627601314348	MT-ND3/MT-ND5/MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/CYBA/MT-ND1/EIF2AK3/COX7B/UQCR10/MT-ATP8/NDUFA13/COX6A1/UQCR11/ATP5F1E/UQCRB/COX7A2/IL1A/NDUFA4/COX5B/COX8A/SLC25A6/NDUFB3/NDUFB4/NDUFB7	11.1992036204759
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	22/166	157/9376	7.91466502954493	MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/EIF2AK3/COX7B/UQCR10/NDUFA13/PRKAG2/COX6A1/UQCR11/UQCRB/COX7A2/IL1A/NDUFA4/COX5B/COX8A/NDUFB3/NDUFB4/NDUFB7	11.7297547562966
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	28/166	308/9376	5.13472070098576	MT-ND3/MT-ND5/MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/MT-ND1/COX7B/UQCR10/MT-ATP8/NDUFA13/COX6A1/HIP1/UQCR11/ATP5F1E/UQCRB/COX7A2/NDUFA4/POLR2L/COX5B/COX8A/SLC25A6/NDUFB3/NDUFB4/NDUFB7	9.90548279715182
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	30/166	388/9376	4.36715935908583	MT-ND3/MT-ND5/MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/MT-ND1/EIF2AK3/COX7B/UQCR10/MT-ATP8/NDUFA13/COX6A1/UQCR11/ATP5F1E/UQCRB/LPL/COX7A2/CALM1/IL1A/NDUFA4/COX5B/COX8A/SLC25A6/NDUFB3/NDUFB4/NDUFB7	9.09406112537958
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	32/166	480/9376	3.76546184738956	MT-ND3/MT-ND5/MT-CYB/COX7C/UBA52/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/MT-ND1/EIF2AK3/COX7B/UQCR10/MT-ATP8/NDUFA13/COX6A1/HIP1/UQCR11/ATP5F1E/SQSTM1/UQCRB/COX7A2/CALM1/IL1A/NDUFA4/COX5B/COX8A/SLC25A6/NDUFB3/NDUFB4/NDUFB7	8.35027483855762
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	27/166	368/9376	4.1440544787847	MT-ND3/MT-ND5/MT-CYB/COX7C/NDUFA1/COX6C/NDUFB2/COX6B1/MT-ND4/MT-ND1/EIF2AK3/COX7B/UQCR10/MT-ATP8/NDUFA13/COX6A1/UQCR11/ATP5F1E/SQSTM1/UQCRB/COX7A2/NDUFA4/COX5B/COX8A/NDUFB3/NDUFB4/NDUFB7	8.26056305060245
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/166	87/9376	7.79061071873702	MT-CYB/COX7C/COX6C/COX6B1/COX7B/UQCR10/COX6A1/UQCR11/UQCRB/COX7A2/COX5B/COX8A	8.54267426001584
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/166	149/9376	4.54888008409477	MT-ND3/MT-ND5/NDUFA1/NDUFB2/MT-ND4/MT-ND1/NDUFA13/MGLL/NDUFA4/NDUFB3/NDUFB4/NDUFB7	5.86224636343536
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/166	44/9376	6.4184008762322	HLA-B/HLA-DQA2/HLA-DQB2/IL1A/HLA-F	4.83637506201966
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/166	45/9376	6.27576974564926	HLA-B/HLA-DQA2/HLA-DQB2/IL1A/HLA-F	4.76253151285437
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/166	181/9376	3.12054849231179	HLA-DQA2/FCER1G/ITGB2/HLA-DQB2/PLK3/LSP1/CALM1/CORO1A/ITGAX/IL1A	3.8674214001693
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/166	70/9376	4.84130808950086	HLA-B/HLA-DQA2/CD55/ITGB2/HLA-DQB2/HLA-F	4.33068408439947
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/166	100/9376	3.95373493975904	HLA-DQA2/ITGA6/CD55/HLA-DQB2/CD44/IL1A/CD9	3.98658489995842
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/166	78/9376	4.34476367006488	HLA-DQA2/CYBA/ITGB2/HLA-DQB2/IL1A/MARCKSL1	3.98224370958105
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/166	54/9376	5.22980812137439	HLA-B/HLA-DQA2/CGA/HLA-DQB2/HLA-F	4.18478224546518
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/166	39/9376	5.79301822675317	HLA-B/HLA-DQA2/HLA-DQB2/HLA-F	4.026684210543
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/166	155/9376	2.91519626894675	HLA-B/OLR1/HLA-DQA2/CYBA/ITGB2/HLA-DQB2/CORO1A/HLA-F	3.22775076104777
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/166	212/9376	2.39781768583769	RALA/VEGFB/ITGB2/FGF18/RAPGEF1/TLN1/CALM1/GNAS/PDGFA	2.76366748101155
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/166	82/9376	3.4440199823685	HLA-B/HLA-DQA2/HLA-DQB2/HLA-F/IFI30	2.98414699190585
Human Diseases	Immune disease	hsa05310	Asthma	3/166	32/9376	5.29518072289157	HLA-DQA2/FCER1G/HLA-DQB2	3.26738178196366
NA	NA	hsa04518	Integrin signaling	7/166	154/9376	2.56736035049288	ITGA6/VEGFB/ITGB2/TLN1/ITGAX/FLNA/PDGFA	2.63285247251881
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/166	88/9376	3.2092004381161	SERPINE1/PLAUR/CD55/ITGB2/ITGAX	2.79527937777637
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/166	157/9376	2.51830250940066	HLA-B/SERPINE1/SQSTM1/CALM1/IL1A/HLA-F/SLC25A6	2.57558623664977
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	9/166	232/9376	2.19110926464479	ITGA6/ITGB2/RGCC/GSN/FGF18/GNA12/ITGAX/LIMK1/PDGFA	2.46625144969755
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/166	160/9376	2.4710843373494	HLA-B/HLA-DQA2/ITGA6/ITGB2/HLA-DQB2/CADM1/HLA-F	2.51962667181143
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/166	95/9376	2.97273303741281	HLA-DQA2/CCL20/ITGB2/HLA-DQB2/IL1A	2.59443384520419
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/166	66/9376	3.42314713399051	HLA-DQA2/HLA-DQB2/IL1A/STAT4	2.65208097318691
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/166	254/9376	2.00132814723461	VEGFB/FGF18/ORAI2/CALM1/CAMK1D/PHKG1/GNAS/SLC25A6/PDGFA	2.17199147231444
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/166	105/9376	2.68961560527826	FCER1G/PLK3/LSP1/CALM1/IRF1	2.33737900158674
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/166	107/9376	2.63934241639455	PRKAG2/CALM1/PHKG1/GNAS/FBP1	2.28957561419719
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/166	76/9376	2.97273303741281	OLR1/CYP27A1/LPL/FABP5	2.31816052836199
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/166	78/9376	2.89650911337658	ITGB2/CALM1/IL1A/IRF1	2.25796565374693
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/166	52/9376	3.25857275254866	APOC2/CYP27A1/LPL	2.19252468174431
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/166	205/9376	1.92865119012636	HLA-B/HLA-DQA2/VIM/HLA-DQB2/CD44/RUNX3/HLA-F	1.80480826267761
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/166	93/9376	2.4293302241223	HLA-DQA2/HLA-DQB2/RUNX3/STAT4	1.85968652143824
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/166	93/9376	2.4293302241223	CGA/HBEGF/CALM1/GNAS	1.85968652143824
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/166	59/9376	2.87196242597509	CGA/MGLL/GNAS	1.93639945853733
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/166	133/9376	2.12338074100915	HLA-B/FCER1G/ITGB2/TYROBP/HCST	1.75168570261348
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/166	138/9376	2.04644665618998	PRKAG2/RAPGEF1/CALM1/PHKG1/FBP1	1.66256075978736
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	7/166	224/9376	1.76506024096386	HLA-B/HLA-DQA2/ITGB2/HLA-DQB2/TLN1/HLA-F/SLC25A6	1.5558635392393
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/166	142/9376	1.98880027150857	CYBA/SQSTM1/CALM1/IL1A/PDGFA	1.59392426157786
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/166	105/9376	2.1516924842226	TOMM7/UBA52/EIF2AK3/SQSTM1	1.59322737106459
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/166	149/9376	1.89536670170615	RALA/FCER1G/GNA12/GNAS/PDGFA	1.47901875144842
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/166	115/9376	1.96458878994238	HBEGF/GNA12/GNAS/PDE4A	1.39724336381841
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/166	75/9376	2.25927710843373	CD82/SERPINE1/ZNF385A	1.46993112283062
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/166	116/9376	1.94765267968425	SDS/ACAT2/ME2/FBP1	1.3787405964355
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/166	203/9376	1.6694165825865	ITGA6/VEGFB/RAPGEF1/TLN1/FLNA/PDGFA	1.29448986841668
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/166	76/9376	2.22954977805961	CALM1/CAMK1D/PDGFA	1.44484515091414
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/166	10/9376	5.64819277108434	SQOR	1.97431716488593
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/166	47/9376	2.4034862855678	ACAT2/ME2	1.29493933374537
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/166	50/9376	2.25927710843373	HLA-DQA2/HLA-DQB2	1.19858399018703
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/166	52/9376	2.17238183503244	CGA/GNAS	1.13809754715082
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/166	142/9376	1.59104021720686	CYBA/TYROBP/SQSTM1/IL1A	0.952743813810827
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/166	238/9376	1.42391414397084	RALA/VEGFB/FGF18/CALM1/RASA3/PDGFA	0.889304880878274
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/166	98/9376	1.72903860339316	GSN/LIMK1/MARCKSL1	0.973971493888269
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/166	98/9376	1.72903860339316	CALM1/CAMK1D/GNAS	0.973971493888269
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/166	99/9376	1.71157356699525	HLA-DQA2/ITGB2/HLA-DQB2	0.95552816545915
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/166	99/9376	1.71157356699525	LMNA/ITGA6/PRKAG2	0.95552816545915
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/166	17/9376	3.32246633593196	CYP27A1	1.28667550089854
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/166	101/9376	1.67768102111416	SERPINE1/VEGFB/IL1A	0.91926117481632
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/166	103/9376	1.64510469060709	ITGB2/GNAS/SERPINB9	0.883788913359285
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/166	18/9376	3.13788487282463	MANBA	1.21881815191941
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/166	18/9376	3.13788487282463	ZNF143	1.21881815191941
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/166	300/9376	1.31791164658635	VEGFB/FGF18/GNA12/DUSP2/IL1A/FLNA/PDGFA	0.751328199243259
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/166	105/9376	1.61376936316695	LMNA/ITGA6/GNAS	0.849075740542443
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/166	60/9376	1.88273092369478	GNA12/GNAS	0.920871629664269
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/166	154/9376	1.4670630574245	PRKAG2/CALM1/CAMK1D/GNAS	0.784572689474759
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/166	157/9376	1.43903000537181	SMAD7/SERPINE1/ITGB2/ID2	0.744752532720411
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/166	21/9376	2.68961560527826	CHST13	1.04060409494816
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/166	112/9376	1.51290877796902	HLA-DQA2/ITGA6/HLA-DQB2	0.733094121382752
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/166	65/9376	1.73790546802595	MGLL/LPL	0.80143648702158
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/166	214/9376	1.31967120819728	HLA-B/ELOB/CALM1/HLA-F/LIMK1	0.635075169122171
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/166	23/9376	2.45573598742797	ACAT2	0.93838473928132
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/166	69/9376	1.63715732495198	CALM1/GNAS	0.713142363084398
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/166	69/9376	1.63715732495198	CALM1/GNAS	0.713142363084398
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/166	168/9376	1.34480780263913	SQSTM1/IL1A/STAT4/SLC25A6	0.605423030388842
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/166	70/9376	1.61376936316695	RAPGEF1/ELOB	0.691962516577136
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/166	119/9376	1.42391414397084	CCL20/TRAF1/IRF1	0.624778567580003
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/166	71/9376	1.59104021720686	CGA/IRF1	0.671116453091563
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/166	173/9376	1.30594052510621	HLA-DQA2/HLA-DQB2/IL1A/SLC25A6	0.5452619789383
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/166	73/9376	1.54745007426968	FGF18/PDGFA	0.630382728602552
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/166	227/9376	1.24409532402739	HLA-B/GNA12/CALM1/HLA-F/GNAS	0.499799067982347
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/166	27/9376	2.09192324854975	ACAT2	0.762783485960776
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/166	75/9376	1.50618473895582	CGA/GNAS	0.590860182171102
Organismal Systems	Immune system	hsa04611	Platelet activation	3/166	126/9376	1.34480780263913	FCER1G/TLN1/GNAS	0.523120040771822
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/166	76/9376	1.4863665187064	CALM1/GNAS	0.571529773466296
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/166	180/9376	1.25515394912985	HLA-B/HLA-DQA2/HLA-DQB2/HLA-F	0.464033070606774
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/166	233/9376	1.21205853456745	VIM/LMNA/ITGA6/FBN2/TLN1	0.440047161187471
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/166	29/9376	1.94765267968425	CALM1	0.686154537622838
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/166	134/9376	1.26452076964575	GNA12/CALM1/GNAS	0.41403691297635
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/166	31/9376	1.82199766809172	FBP1	0.615420057790427
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/166	31/9376	1.82199766809172	ACAT2	0.615420057790427
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/166	31/9376	1.82199766809172	SEC62	0.615420057790427
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/166	137/9376	1.23683053381409	LMNA/EIF2AK3/TRAF1	0.374882667078672
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/166	139/9376	1.2190344110254	HBEGF/CALM1/GNAS	0.349272300515801
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/166	86/9376	1.31353320257775	LMNA/ITGA6	0.392134248176716
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/166	140/9376	1.21032702237522	SERPINE1/PRKAG2/CALM1	0.336609986447892
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/166	34/9376	1.66123316796598	POLR2L	0.518542102383347
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/166	34/9376	1.66123316796598	PRKAG2	0.518542102383347
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	4/166	196/9376	1.15269240226211	HLA-B/UBA52/CALM1/HLA-F	0.290024034690463
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/166	35/9376	1.61376936316695	FBP1	0.488373859140344
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/166	89/9376	1.26925680249086	ITGA6/CD44	0.342636663028576
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/166	89/9376	1.26925680249086	GNAS/PDGFA	0.342636663028576
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/166	91/9376	1.24136104858996	GNAS/PDE4A	0.310603820394391
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	4/166	204/9376	1.10748877864399	PLAUR/CD44/HBEGF/FLNA	0.208380010697029
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/166	93/9376	1.21466511206115	CALM1/GNAS	0.279298519534411
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/166	93/9376	1.21466511206115	ITGA6/TRAF1	0.279298519534411
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/166	205/9376	1.10208639435792	HLA-B/GSN/HLA-F/TRAF1	0.198402123427062
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/166	97/9376	1.16457582908955	CALM1/GNAS	0.218731433159534
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/166	41/9376	1.3776079929474	SDS	0.325301310528467
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/166	41/9376	1.3776079929474	HBEGF	0.325301310528467
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/166	98/9376	1.15269240226211	SYNJ2/CALM1	0.203992005971202
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/166	99/9376	1.1410490446635	HBEGF/GNAS	0.189406044769481
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/166	99/9376	1.1410490446635	CALM1/GNAS	0.189406044769481
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/166	42/9376	1.34480780263913	ACAT2	0.300661416309572
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	4/166	216/9376	1.04596162427488	OLR1/CYBA/EIF2AK3/CALM1	0.0917454159594537
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/166	43/9376	1.31353320257775	ACAT2	0.276641289672607
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/166	43/9376	1.31353320257775	ACAT2	0.276641289672607
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/166	101/9376	1.11845401407611	CALM1/GNAS	0.160680575003099
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/166	44/9376	1.28368017524644	GNAS	0.253208235509014
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/166	103/9376	1.09673646040473	SERPINE1/GNAS	0.132528274043178
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/166	166/9376	1.02075772971404	GNA12/CALM1/SLC25A6	0.0362254633195755
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/166	226/9376	0.999680136475104	CGA/CALM1/GNAS/PDE4A	-0.000653458871660032
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/166	48/9376	1.17670682730924	ACAT2	0.16477432699908
NA	NA	hsa03272	Virion - Hepatitis viruses	1/166	48/9376	1.17670682730924	CD9	0.16477432699908
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/166	109/9376	1.03636564607052	HLA-DQA2/HLA-DQB2	0.0512678189806154
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/166	169/9376	1.00263777001497	UBA52/EIF2AK3/SQSTM1	0.00464548513720171
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/166	110/9376	1.02694414019715	SERPINE1/ELOB	0.0381614081157156
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/166	110/9376	1.02694414019715	SMAD7/ID2	0.0381614081157156
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/166	49/9376	1.15269240226211	GNAS	0.143864733824841
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/166	50/9376	1.12963855421687	ITGB2	0.12339039164191
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/166	51/9376	1.10748877864399	GNAS	0.103331721106191
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/166	174/9376	0.973826339842127	EIF2AK3/SEC62/SSR4	-0.0467851295050444
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/166	116/9376	0.973826339842127	CYBA/ITGB2	-0.0380800778498187
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/166	53/9376	1.0656967492612	GNAS	0.0643893202896361
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/166	54/9376	1.04596162427488	SDS	0.0454723674736695
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/166	55/9376	1.02694414019715	PSAP	0.0269044604779018
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/166	120/9376	0.941365461847389	RAPGEF1/CALM1	-0.0867845320119382
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/166	56/9376	1.00860585197935	ITGB2	0.00867141150654953
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/166	184/9376	0.92090099528549	UNC5B/SEMA3C/LIMK1	-0.145473802097108
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/166	57/9376	0.990911012470936	ACAT2	-0.00924013138808204
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/166	122/9376	0.925933241161367	PRKAG2/FBP1	-0.110547359907958
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/166	59/9376	0.957320808658362	NME4	-0.0441483022618416
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/166	125/9376	0.903710843373494	FCER1G/GNA12	-0.145494948787263
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/166	253/9376	0.892994904519263	UBA52/CD44/SQSTM1/TLN1	-0.231635835949312
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/166	61/9376	0.925933241161367	ATOX1	-0.0779124202479786
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/166	128/9376	0.882530120481928	NME4/PDE4A	-0.179645964048628
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/166	62/9376	0.910998834045861	PRKAG2	-0.0943915877137577
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/166	130/9376	0.868952734012975	VEGFB/GNAS	-0.20199125312718
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/166	195/9376	0.868952734012975	CYBA/ITGB2/SLC25A6	-0.248261939484605
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/166	63/9376	0.896538535092752	ACAT2	-0.110614984711501
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/166	63/9376	0.896538535092752	POLR2L	-0.110614984711501
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/166	133/9376	0.84935229640366	PRKAG2/PLK3	-0.234904711188309
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/166	133/9376	0.84935229640366	CALM1/GNAS	-0.234904711188309
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/166	65/9376	0.868952734012975	GNAS	-0.142329966421567
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/166	65/9376	0.868952734012975	CGA	-0.142329966421567
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/166	201/9376	0.843013846430498	ID2/TRAF1/PDGFA	-0.302041214577773
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/166	67/9376	0.843013846430498	FBP1	-0.173123929883527
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/166	67/9376	0.843013846430498	CALM1	-0.173123929883527
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/166	68/9376	0.830616583982991	DHRS4L2	-0.188194541763375
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	5/166	333/9376	0.848076992655306	HLA-B/ITGA6/HLA-F/GNAS/IRF1	-0.378965144366392
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/166	69/9376	0.818578662475991	FCER1G	-0.203056978691337
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/166	70/9376	0.806884681583477	PRKAG2	-0.217717875378448
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/166	71/9376	0.795520108603428	HBEGF	-0.232183556122691
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/166	71/9376	0.795520108603428	SLC16A3	-0.232183556122691
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/166	142/9376	0.795520108603428	UBA52/ELOB	-0.329617081723241
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/166	143/9376	0.789957030920886	HLA-DQA2/HLA-DQB2	-0.33979314780769
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/166	73/9376	0.773725037134841	MDFIC	-0.260553126594543
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/166	75/9376	0.753092369477912	SDS	-0.288210758488411
NA	NA	hsa04382	Cornified envelope formation	3/166	217/9376	0.780856143467881	ITGA6/S100A11/ST14	-0.438475169560666
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/166	77/9376	0.733531528712252	RALA	-0.315197624873394
NA	NA	hsa04081	Hormone signaling	3/166	219/9376	0.773725037134841	CGA/GNA12/GNAS	-0.454874739354163
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/166	78/9376	0.724127278344146	SYNJ2	-0.328451430004237
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/166	78/9376	0.724127278344146	BTG1	-0.328451430004237
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/166	154/9376	0.733531528712252	CALM1/GNAS	-0.447613832554611
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/166	80/9376	0.706024096385542	PDGFA	-0.354501875407983
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/166	82/9376	0.6888039964737	NME4	-0.379970141208164
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/166	157/9376	0.719515002685903	GPR132/DUSP2	-0.475803269899161
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/166	83/9376	0.680505153142691	POLR2L	-0.392495609042858
NA	NA	hsa04517	IgSF CAM signaling	4/166	299/9376	0.755611073054761	UNC5B/ITGB2/CADM1/ITGAX	-0.576575013795824
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/166	85/9376	0.664493267186393	NME4	-0.417147206672222
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/166	86/9376	0.656766601288876	HBEGF	-0.429280119764502
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/166	86/9376	0.656766601288876	GNAS	-0.429280119764502
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/166	87/9376	0.649217559894751	RALA	-0.441288750904867
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/166	90/9376	0.627576974564926	PRKAG2	-0.47659919670192
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/166	90/9376	0.627576974564926	GNAS	-0.47659919670192
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/166	168/9376	0.672403901319564	STAT4/PDGFA	-0.575202246841978
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/166	93/9376	0.607332556030574	SNAI1	-0.510895481417502
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/166	94/9376	0.600871571391951	CCL20	-0.522114403423748
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/166	250/9376	0.67778313253012	LAPTM5/PSAP/MANBA	-0.693246858869043
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/166	323/9376	0.699466597038308	VIM/CD44/ST14/PDGFA	-0.737917172256092
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/166	99/9376	0.570524522331751	PDGFA	-0.576716075920188
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/166	100/9376	0.564819277108434	CCL20	-0.587352939249871
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/166	102/9376	0.553744389321994	GNAS	-0.608359223184327
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/166	105/9376	0.537923121055651	TRAF1	-0.639227520501854
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/166	106/9376	0.532848374630598	PDGFA	-0.649352918676782
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/166	191/9376	0.591433798019302	CALM1/GNAS	-0.765860036057376
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/166	109/9376	0.51818282303526	PRKAG2	-0.6792596441839
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/166	193/9376	0.585304950371434	CCL20/FGR	-0.781492978803393
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/166	115/9376	0.491147197485595	GNAS	-0.737092540248291
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/166	116/9376	0.486913169921064	GNAS	-0.74649041499248
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/166	122/9376	0.462966620580683	GNAS	-0.801542057572637
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	4/166	362/9376	0.624109698462358	ITGA6/VEGFB/FGF18/PDGFA	-0.979188932257952
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/166	217/9376	0.52057076231192	FGF18/GNAS	-0.959268580987169
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	3/166	298/9376	0.568610010511846	CCL20/IL1A/RELT	-1.01599828047724
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/166	136/9376	0.415308291991495	IL1A	-0.922083541991518
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/166	138/9376	0.409289331237995	CALM1	-0.938502094169972
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/166	138/9376	0.409289331237995	LIMK1	-0.938502094169972
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/166	144/9376	0.392235609103079	ID2	-0.986684864547081
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/166	144/9376	0.392235609103079	PRKAG2	-0.986684864547081
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/166	144/9376	0.392235609103079	SLC25A6	-0.986684864547081
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/166	148/9376	0.381634646694888	FGF18	-1.01796320449639
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/166	150/9376	0.376546184738956	FGF18	-1.03336335951723
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	2/166	248/9376	0.45549941702293	RALA/FLNA	-1.16666519259878
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/166	154/9376	0.366765764356126	NME4	-1.0637070935693
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/166	155/9376	0.364399533618344	GNAS	-1.07120085933226
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	2/166	250/9376	0.451855421686747	HLA-B/HLA-F	-1.17932841351727
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/166	163/9376	0.346514893931554	STAT4	-1.12989692711819
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/166	170/9376	0.332246633593196	PRKAG2	-1.1795461262602
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/166	187/9376	0.302042394175633	CYBA	-1.29427209839987
NA	NA	hsa04082	Neuroactive ligand signaling	1/166	199/9376	0.28382878246655	GNAS	-1.37089092808634
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/166	200/9376	0.282409638554217	GNA12	-1.37712942909373
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/166	243/9376	0.232435916505528	DDX46	-1.62749970965414
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/166	370/9376	0.152653858677955	CGA	-2.23257272090095
NA	NA	hsa04519	Cadherin signaling	1/166	404/9376	0.139806751759513	VIM	-2.37274980634532
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/166	449/9376	0.125794939222368	CALM1	-2.54855251219341