ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 40/222 175/18639 0.228571428571429 19.1907335907336 3.76058343830734e-40 2.20746247828641e-37 GO:0009055 electron transfer activity 20/222 116/18639 0.172413793103448 14.4757688723206 7.15281580829332e-18 2.09935143973409e-15 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 16/222 68/18639 0.235294117647059 19.7551669316375 8.09151631167738e-17 1.58324002498487e-14 GO:0015078 proton transmembrane transporter activity 20/222 185/18639 0.108108108108108 9.07669831994156 7.7411721094623e-14 1.13601700706359e-11 GO:0022853 active monoatomic ion transmembrane transporter activity 16/222 118/18639 0.135593220338983 11.3843334860284 7.59433033279595e-13 8.91574381070245e-11 GO:0008137 NADH dehydrogenase (ubiquinone) activity 10/222 41/18639 0.24390243902439 20.4779169413316 3.80850684960431e-11 3.72598920119622e-09 GO:0003954 NADH dehydrogenase activity 10/222 44/18639 0.227272727272727 19.0816953316953 8.17053725826131e-11 6.85157910085627e-09 GO:0015399 primary active transmembrane transporter activity 16/222 166/18639 0.0963855421686747 8.09247802018886 1.48526119495923e-10 1.08981040180133e-08 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 10/222 58/18639 0.172413793103448 14.4757688723206 1.48577880079062e-09 9.69057951182326e-08 GO:0016651 oxidoreductase activity, acting on NAD(P)H 11/222 88/18639 0.125 10.4949324324324 7.65136207399045e-09 4.49134953743239e-07 GO:0022804 active transmembrane transporter activity 19/222 457/18639 0.0415754923413567 3.4906558637412 2.52209801077264e-06 0.000134588321120322 GO:0004129 cytochrome-c oxidase activity 4/222 15/18639 0.266666666666667 22.3891891891892 2.41187054378315e-05 0.00117980667433393 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/222 16/18639 0.25 20.9898648648649 3.18584832846536e-05 0.00143853305293013 GO:0031386 protein tag activity 3/222 15/18639 0.2 16.7918918918919 0.0006823178954799 0.0267013736431134 GO:0141047 molecular tag activity 3/222 15/18639 0.2 16.7918918918919 0.0006823178954799 0.0267013736431134 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 3/222 18/18639 0.166666666666667 13.9932432432432 0.0011918333875444 0.0437253874055353 GO:0042605 peptide antigen binding 4/222 45/18639 0.0888888888888889 7.46306306306306 0.00199076198921702 0.0687398404511993 GO:0043548 phosphatidylinositol 3-kinase binding 3/222 26/18639 0.115384615384615 9.68762993762994 0.00354048169757014 0.115459042026315 GO:0015252 proton channel activity 3/222 27/18639 0.111111111111111 9.32882882882883 0.00394839258100747 0.121984549739547 GO:0032395 MHC class II receptor activity 2/222 10/18639 0.2 16.7918918918919 0.00596729945664017 0.169910893224451 GO:0070851 growth factor receptor binding 6/222 139/18639 0.0431654676258993 3.6241493291853 0.0064533039485594 0.169910893224451 GO:0005507 copper ion binding 4/222 63/18639 0.0634920634920635 5.33075933075933 0.00674064938234473 0.169910893224451 GO:0045296 cadherin binding 10/222 334/18639 0.029940119760479 2.5137562712413 0.00691389268434969 0.169910893224451 GO:0010854 adenylate cyclase regulator activity 2/222 11/18639 0.181818181818182 15.2653562653563 0.007236409421825 0.169910893224451 GO:1990948 ubiquitin ligase inhibitor activity 2/222 11/18639 0.181818181818182 15.2653562653563 0.007236409421825 0.169910893224451 GO:0010853 cyclase activator activity 2/222 12/18639 0.166666666666667 13.9932432432432 0.00861594312716292 0.18062709341588 GO:0016208 AMP binding 2/222 12/18639 0.166666666666667 13.9932432432432 0.00861594312716292 0.18062709341588 GO:0097371 MDM2/MDM4 family protein binding 2/222 12/18639 0.166666666666667 13.9932432432432 0.00861594312716292 0.18062709341588 GO:0005518 collagen binding 4/222 72/18639 0.0555555555555556 4.66441441441441 0.0107189291741785 0.216965911215268 GO:0016530 metallochaperone activity 2/222 14/18639 0.142857142857143 11.9942084942085 0.0116951870706838 0.22883582701638 GO:0017022 myosin binding 4/222 76/18639 0.0526315789473684 4.41891891891892 0.0128867098745967 0.23817035186032 GO:0050780 dopamine receptor binding 2/222 15/18639 0.133333333333333 11.1945945945946 0.0133894746360998 0.23817035186032 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/222 15/18639 0.133333333333333 11.1945945945946 0.0133894746360998 0.23817035186032 GO:0048038 quinone binding 2/222 17/18639 0.117647058823529 9.87758346581876 0.0170741900572099 0.294780869517124 GO:0035254 glutamate receptor binding 3/222 49/18639 0.0612244897959184 5.1403750689465 0.0205481892566489 0.335331302102661 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/222 19/18639 0.105263157894737 8.83783783783784 0.0211367260269139 0.335331302102661 GO:0034987 immunoglobulin receptor binding 2/222 19/18639 0.105263157894737 8.83783783783784 0.0211367260269139 0.335331302102661 GO:0010851 cyclase regulator activity 2/222 20/18639 0.1 8.39594594594595 0.0233034630735308 0.353723857902744 GO:0019838 growth factor binding 5/222 136/18639 0.0367647058823529 3.08674483306836 0.0235012443921755 0.353723857902744 GO:0030295 protein kinase activator activity 5/222 139/18639 0.0359712230215827 3.02012444098775 0.0255232870247236 0.365905584139218 GO:0072542 protein phosphatase activator activity 2/222 21/18639 0.0952380952380952 7.996138996139 0.0255572895225008 0.365905584139218 GO:0003925 G protein activity 3/222 54/18639 0.0555555555555556 4.66441441441441 0.0264987861075953 0.370352082027581 GO:0031683 G-protein beta/gamma-subunit complex binding 2/222 22/18639 0.0909090909090909 7.63267813267813 0.0278958432854483 0.380810697873446 GO:0031625 ubiquitin protein ligase binding 8/222 302/18639 0.0264900662251656 2.22409164131018 0.0286498142656969 0.382214567590093 GO:0017134 fibroblast growth factor binding 2/222 23/18639 0.0869565217391304 7.30082256169213 0.0303168057408918 0.395465888220078 GO:0019209 kinase activator activity 5/222 148/18639 0.0337837837837838 2.83646822498174 0.0322457046462431 0.409874636413241 GO:0048027 mRNA 5'-UTR binding 2/222 24/18639 0.0833333333333333 6.99662162162162 0.0328179010416053 0.409874636413241 GO:0019211 phosphatase activator activity 2/222 25/18639 0.08 6.71675675675676 0.0353968954321949 0.432874533722883 GO:0051015 actin filament binding 6/222 209/18639 0.0287081339712919 2.41031941031941 0.0393942746443406 0.451656106607365 GO:0044389 ubiquitin-like protein ligase binding 8/222 322/18639 0.0248447204968944 2.08594930334061 0.0395122516299324 0.451656106607365 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/222 27/18639 0.0740740740740741 6.21921921921922 0.0407798528964061 0.451656106607365 GO:0023026 MHC class II protein complex binding 2/222 27/18639 0.0740740740740741 6.21921921921922 0.0407798528964061 0.451656106607365 GO:0035255 ionotropic glutamate receptor binding 2/222 27/18639 0.0740740740740741 6.21921921921922 0.0407798528964061 0.451656106607365 GO:0019843 rRNA binding 3/222 65/18639 0.0461538461538462 3.87505197505198 0.042470642825434 0.461671617380181 GO:0005178 integrin binding 5/222 161/18639 0.031055900621118 2.60743662917576 0.0437509226669452 0.466941665554488 GO:0005200 structural constituent of cytoskeleton 4/222 112/18639 0.0357142857142857 2.99855212355212 0.0450007833275044 0.470092114736992 GO:0003785 actin monomer binding 2/222 29/18639 0.0689655172413793 5.79030754892824 0.0464486246247794 0.470092114736992 GO:0043236 laminin binding 2/222 29/18639 0.0689655172413793 5.79030754892824 0.0464486246247794 0.470092114736992 GO:0035401 histone H3Y41 kinase activity 4/222 115/18639 0.0347826086956522 2.92032902467685 0.04875770529818 0.477012883500528 GO:0140801 histone H2AXY142 kinase activity 4/222 115/18639 0.0347826086956522 2.92032902467685 0.04875770529818 0.477012883500528 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/222 70/18639 0.0428571428571429 3.59826254826255 0.0510055835890504 0.490824222406108 GO:0140311 protein sequestering activity 2/222 33/18639 0.0606060606060606 5.08845208845209 0.0585785340128207 0.545803166119456 GO:0140416 transcription regulator inhibitor activity 2/222 33/18639 0.0606060606060606 5.08845208845209 0.0585785340128207 0.545803166119456 GO:0016831 carboxy-lyase activity 2/222 34/18639 0.0588235294117647 4.93879173290938 0.0617647212948079 0.566498303125817 GO:0005154 epidermal growth factor receptor binding 2/222 35/18639 0.0571428571428571 4.7976833976834 0.0650086420526645 0.587078044383293 GO:0046332 SMAD binding 3/222 79/18639 0.0379746835443038 3.18833390352378 0.0682717730236182 0.590295473217744 GO:0055106 ubiquitin-protein transferase regulator activity 2/222 36/18639 0.0555555555555556 4.66441441441441 0.0683084832829427 0.590295473217744 GO:0005539 glycosaminoglycan binding 6/222 242/18639 0.0247933884297521 2.0816394907304 0.0700625960262453 0.590295473217744 GO:0031072 heat shock protein binding 4/222 131/18639 0.0305343511450382 2.56364761708273 0.0716075710372151 0.590295473217744 GO:0023023 MHC protein complex binding 2/222 37/18639 0.0540540540540541 4.53834915997078 0.0716624666314092 0.590295473217744 GO:0003779 actin binding 9/222 443/18639 0.0203160270880361 1.70572265267525 0.0838992679288107 0.590295473217744 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/222 41/18639 0.0487804878048781 4.09558338826632 0.0855854356068305 0.590295473217744 GO:0004713 protein tyrosine kinase activity 4/222 140/18639 0.0285714285714286 2.3988416988417 0.0864798391001126 0.590295473217744 GO:0051879 Hsp90 protein binding 2/222 42/18639 0.0476190476190476 3.9980694980695 0.089184628081296 0.590295473217744 GO:0003924 GTPase activity 7/222 331/18639 0.0211480362537764 1.77557769249612 0.101634117058331 0.590295473217744 GO:0005516 calmodulin binding 5/222 207/18639 0.0241545893719807 2.0280062671367 0.101923049813643 0.590295473217744 GO:0030276 clathrin binding 2/222 46/18639 0.0434782608695652 3.65041128084606 0.10400772588189 0.590295473217744 GO:0004867 serine-type endopeptidase inhibitor activity 3/222 95/18639 0.0315789473684211 2.65135135135135 0.104462900755859 0.590295473217744 GO:0004090 carbonyl reductase (NADPH) activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0015279 store-operated calcium channel activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0016427 tRNA (cytidine) methyltransferase activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0030957 Tat protein binding 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0031720 haptoglobin binding 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0031996 thioesterase binding 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0035374 chondroitin sulfate binding 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0043208 glycosphingolipid binding 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0050308 sugar-phosphatase activity 1/222 10/18639 0.1 8.39594594594595 0.112945804168985 0.590295473217744 GO:0001222 transcription corepressor binding 2/222 49/18639 0.0408163265306122 3.426916712631 0.115530938209375 0.590295473217744 GO:0140375 immune receptor activity 4/222 156/18639 0.0256410256410256 2.15280665280665 0.116256382748899 0.590295473217744 GO:0043130 ubiquitin binding 3/222 100/18639 0.03 2.51878378378378 0.117050403121523 0.590295473217744 GO:0016830 carbon-carbon lyase activity 2/222 51/18639 0.0392156862745098 3.29252782193959 0.123385079286564 0.590295473217744 GO:0000099 sulfur amino acid transmembrane transporter activity 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0001851 complement component C3b binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0015173 aromatic amino acid transmembrane transporter activity 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0015217 ADP transmembrane transporter activity 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0019203 carbohydrate phosphatase activity 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0019215 intermediate filament binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0019864 IgG binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0031731 CCR6 chemokine receptor binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0032050 clathrin heavy chain binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0034511 U3 snoRNA binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0034713 type I transforming growth factor beta receptor binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0048407 platelet-derived growth factor binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0070697 activin receptor binding 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0097493 structural molecule activity conferring elasticity 1/222 11/18639 0.0909090909090909 7.63267813267813 0.123516743643702 0.590295473217744 GO:0004857 enzyme inhibitor activity 8/222 416/18639 0.0192307692307692 1.61460498960499 0.125045152801375 0.590295473217744 GO:0005080 protein kinase C binding 2/222 52/18639 0.0384615384615385 3.22920997920998 0.127359703273111 0.590295473217744 GO:0008083 growth factor activity 4/222 162/18639 0.0246913580246914 2.07307307307307 0.128441360313436 0.590295473217744 GO:0141003 histone H2AX kinase activity 7/222 354/18639 0.019774011299435 1.66021530004581 0.131186931443218 0.590295473217744 GO:0005246 calcium channel regulator activity 2/222 53/18639 0.0377358490566038 3.16828148903621 0.131364294058751 0.590295473217744 GO:0008603 cAMP-dependent protein kinase regulator activity 1/222 12/18639 0.0833333333333333 6.99662162162162 0.133962270963387 0.590295473217744 GO:0016840 carbon-nitrogen lyase activity 1/222 12/18639 0.0833333333333333 6.99662162162162 0.133962270963387 0.590295473217744 GO:0017166 vinculin binding 1/222 12/18639 0.0833333333333333 6.99662162162162 0.133962270963387 0.590295473217744 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/222 12/18639 0.0833333333333333 6.99662162162162 0.133962270963387 0.590295473217744 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/222 12/18639 0.0833333333333333 6.99662162162162 0.133962270963387 0.590295473217744 GO:0140996 histone H3 kinase activity 7/222 357/18639 0.0196078431372549 1.64626391096979 0.135330012859965 0.590295473217744 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/222 54/18639 0.037037037037037 3.10960960960961 0.135397582826103 0.590295473217744 GO:0140313 molecular sequestering activity 2/222 55/18639 0.0363636363636364 3.05307125307125 0.139458326480674 0.590295473217744 GO:0035173 histone kinase activity 7/222 360/18639 0.0194444444444444 1.63254504504505 0.139537219136425 0.590295473217744 GO:0106310 protein serine kinase activity 7/222 361/18639 0.0193905817174515 1.62802275960171 0.14095372402923 0.590295473217744 GO:0030170 pyridoxal phosphate binding 2/222 56/18639 0.0357142857142857 2.99855212355212 0.14354530722276 0.590295473217744 GO:0004465 lipoprotein lipase activity 1/222 13/18639 0.0769230769230769 6.45841995841996 0.14428386734746 0.590295473217744 GO:0005172 vascular endothelial growth factor receptor binding 1/222 13/18639 0.0769230769230769 6.45841995841996 0.14428386734746 0.590295473217744 GO:0009982 pseudouridine synthase activity 1/222 13/18639 0.0769230769230769 6.45841995841996 0.14428386734746 0.590295473217744 GO:0019855 calcium channel inhibitor activity 1/222 13/18639 0.0769230769230769 6.45841995841996 0.14428386734746 0.590295473217744 GO:0031432 titin binding 1/222 13/18639 0.0769230769230769 6.45841995841996 0.14428386734746 0.590295473217744 GO:0031994 insulin-like growth factor I binding 1/222 13/18639 0.0769230769230769 6.45841995841996 0.14428386734746 0.590295473217744 GO:0045159 myosin II binding 1/222 13/18639 0.0769230769230769 6.45841995841996 0.14428386734746 0.590295473217744 GO:1902936 phosphatidylinositol bisphosphate binding 3/222 111/18639 0.027027027027027 2.26917457998539 0.146564303568919 0.590295473217744 GO:0004674 protein serine/threonine kinase activity 8/222 433/18639 0.0184757505773672 1.55121403158355 0.146647748313077 0.590295473217744 GO:0070279 vitamin B6 binding 2/222 57/18639 0.0350877192982456 2.94594594594595 0.147657332125822 0.590295473217744 GO:0008201 heparin binding 4/222 172/18639 0.0232558139534884 1.95254556882464 0.149865654933902 0.590295473217744 GO:0003823 antigen binding 4/222 174/18639 0.0229885057471264 1.93010251630941 0.154307046849865 0.590295473217744 GO:0005161 platelet-derived growth factor receptor binding 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:0005344 oxygen carrier activity 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:0005347 ATP transmembrane transporter activity 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:0019763 immunoglobulin receptor activity 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:0032036 myosin heavy chain binding 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:0044548 S100 protein binding 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:0046030 inositol trisphosphate phosphatase activity 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:1901612 cardiolipin binding 1/222 14/18639 0.0714285714285714 5.99710424710425 0.154482996599519 0.590295473217744 GO:0031593 polyubiquitin modification-dependent protein binding 2/222 59/18639 0.0338983050847458 2.8460833715071 0.155951864589382 0.590295473217744 GO:0005041 low-density lipoprotein particle receptor activity 1/222 15/18639 0.0666666666666667 5.5972972972973 0.164561105311192 0.590295473217744 GO:0047372 monoacylglycerol lipase activity 1/222 15/18639 0.0666666666666667 5.5972972972973 0.164561105311192 0.590295473217744 GO:0140161 monocarboxylate:sodium symporter activity 1/222 15/18639 0.0666666666666667 5.5972972972973 0.164561105311192 0.590295473217744 GO:0032182 ubiquitin-like protein binding 3/222 120/18639 0.025 2.09898648648649 0.172311311613402 0.590295473217744 GO:1901682 sulfur compound transmembrane transporter activity 2/222 63/18639 0.0317460317460317 2.66537966537967 0.172791635726739 0.590295473217744 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0005149 interleukin-1 receptor binding 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0005159 insulin-like growth factor receptor binding 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0008296 3'-5'-DNA exonuclease activity 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0015378 sodium:chloride symporter activity 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0015923 mannosidase activity 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0022858 alanine transmembrane transporter activity 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0055102 lipase inhibitor activity 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0070411 I-SMAD binding 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/222 16/18639 0.0625 5.24746621621622 0.174519623063604 0.590295473217744 GO:0004679 AMP-activated protein kinase activity 5/222 248/18639 0.0201612903225806 1.6927310374891 0.17481386475109 0.590295473217744 GO:0042277 peptide binding 5/222 249/18639 0.0200803212851406 1.68593292087268 0.176798754395563 0.590295473217744 GO:0140104 molecular carrier activity 5/222 249/18639 0.0200803212851406 1.68593292087268 0.176798754395563 0.590295473217744 GO:0008237 metallopeptidase activity 4/222 184/18639 0.0217391304347826 1.82520564042303 0.177227314307165 0.590295473217744 GO:0061135 endopeptidase regulator activity 4/222 184/18639 0.0217391304347826 1.82520564042303 0.177227314307165 0.590295473217744 GO:1901981 phosphatidylinositol phosphate binding 4/222 185/18639 0.0216216216216216 1.81533966398831 0.179580873582981 0.590295473217744 GO:0038024 cargo receptor activity 2/222 65/18639 0.0307692307692308 2.58336798336798 0.181319854976012 0.590295473217744 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/222 17/18639 0.0588235294117647 4.93879173290938 0.184359962626503 0.590295473217744 GO:0004550 nucleoside diphosphate kinase activity 1/222 17/18639 0.0588235294117647 4.93879173290938 0.184359962626503 0.590295473217744 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/222 17/18639 0.0588235294117647 4.93879173290938 0.184359962626503 0.590295473217744 GO:0038191 neuropilin binding 1/222 17/18639 0.0588235294117647 4.93879173290938 0.184359962626503 0.590295473217744 GO:0051787 misfolded protein binding 1/222 17/18639 0.0588235294117647 4.93879173290938 0.184359962626503 0.590295473217744 GO:0070492 oligosaccharide binding 1/222 17/18639 0.0588235294117647 4.93879173290938 0.184359962626503 0.590295473217744 GO:0046943 carboxylic acid transmembrane transporter activity 4/222 188/18639 0.0212765957446809 1.78637147786084 0.1867040938906 0.590295473217744 GO:0019887 protein kinase regulator activity 5/222 255/18639 0.0196078431372549 1.64626391096979 0.188885411671726 0.590295473217744 GO:0005342 organic acid transmembrane transporter activity 4/222 189/18639 0.0211640211640212 1.77691977691978 0.189098797787071 0.590295473217744 GO:0050840 extracellular matrix binding 2/222 67/18639 0.0298507462686567 2.50625252117789 0.189909537757454 0.590295473217744 GO:0015373 monoatomic anion:sodium symporter activity 1/222 18/18639 0.0555555555555556 4.66441441441441 0.194083520155067 0.590295473217744 GO:0030228 lipoprotein particle receptor activity 1/222 18/18639 0.0555555555555556 4.66441441441441 0.194083520155067 0.590295473217744 GO:0031690 adrenergic receptor binding 1/222 18/18639 0.0555555555555556 4.66441441441441 0.194083520155067 0.590295473217744 GO:0034185 apolipoprotein binding 1/222 18/18639 0.0555555555555556 4.66441441441441 0.194083520155067 0.590295473217744 GO:0035615 clathrin adaptor activity 1/222 18/18639 0.0555555555555556 4.66441441441441 0.194083520155067 0.590295473217744 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/222 18/18639 0.0555555555555556 4.66441441441441 0.194083520155067 0.590295473217744 GO:0098641 cadherin binding involved in cell-cell adhesion 1/222 18/18639 0.0555555555555556 4.66441441441441 0.194083520155067 0.590295473217744 GO:1901611 phosphatidylglycerol binding 1/222 18/18639 0.0555555555555556 4.66441441441441 0.194083520155067 0.590295473217744 GO:0002039 p53 binding 2/222 69/18639 0.0289855072463768 2.43360752056404 0.19855303771814 0.592081558873807 GO:0097110 scaffold protein binding 2/222 70/18639 0.0285714285714286 2.3988416988417 0.202892668721937 0.592081558873807 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/222 19/18639 0.0526315789473684 4.41891891891892 0.20369167538441 0.592081558873807 GO:0005520 insulin-like growth factor binding 1/222 19/18639 0.0526315789473684 4.41891891891892 0.20369167538441 0.592081558873807 GO:0015245 fatty acid transmembrane transporter activity 1/222 19/18639 0.0526315789473684 4.41891891891892 0.20369167538441 0.592081558873807 GO:0043395 heparan sulfate proteoglycan binding 1/222 19/18639 0.0526315789473684 4.41891891891892 0.20369167538441 0.592081558873807 GO:0097001 ceramide binding 1/222 19/18639 0.0526315789473684 4.41891891891892 0.20369167538441 0.592081558873807 GO:0140036 ubiquitin-modified protein reader activity 1/222 19/18639 0.0526315789473684 4.41891891891892 0.20369167538441 0.592081558873807 GO:0004175 endopeptidase activity 7/222 405/18639 0.0172839506172839 1.45115115115115 0.209675847838882 0.592081558873807 GO:0001972 retinoic acid binding 1/222 20/18639 0.05 4.19797297297297 0.213185791821824 0.592081558873807 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/222 20/18639 0.05 4.19797297297297 0.213185791821824 0.592081558873807 GO:0016004 phospholipase activator activity 1/222 20/18639 0.05 4.19797297297297 0.213185791821824 0.592081558873807 GO:0016408 C-acyltransferase activity 1/222 20/18639 0.05 4.19797297297297 0.213185791821824 0.592081558873807 GO:0052745 inositol phosphate phosphatase activity 1/222 20/18639 0.05 4.19797297297297 0.213185791821824 0.592081558873807 GO:0008514 organic anion transmembrane transporter activity 5/222 269/18639 0.0185873605947955 1.56058474831709 0.218174545703923 0.592081558873807 GO:0048029 monosaccharide binding 2/222 74/18639 0.027027027027027 2.26917457998539 0.220349958187877 0.592081558873807 GO:0002020 protease binding 3/222 136/18639 0.0220588235294118 1.85204689984102 0.220805028855523 0.592081558873807 GO:0044325 transmembrane transporter binding 3/222 136/18639 0.0220588235294118 1.85204689984102 0.220805028855523 0.592081558873807 GO:0001846 opsonin binding 1/222 21/18639 0.0476190476190476 3.9980694980695 0.22256721693679 0.592081558873807 GO:0010314 phosphatidylinositol-5-phosphate binding 1/222 21/18639 0.0476190476190476 3.9980694980695 0.22256721693679 0.592081558873807 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/222 21/18639 0.0476190476190476 3.9980694980695 0.22256721693679 0.592081558873807 GO:0051428 peptide hormone receptor binding 1/222 21/18639 0.0476190476190476 3.9980694980695 0.22256721693679 0.592081558873807 GO:0140312 cargo adaptor activity 1/222 21/18639 0.0476190476190476 3.9980694980695 0.22256721693679 0.592081558873807 GO:0003725 double-stranded RNA binding 2/222 75/18639 0.0266666666666667 2.23891891891892 0.224734781013866 0.592081558873807 GO:0005126 cytokine receptor binding 5/222 275/18639 0.0181818181818182 1.52653562653563 0.231141222921365 0.592081558873807 GO:1901681 sulfur compound binding 5/222 275/18639 0.0181818181818182 1.52653562653563 0.231141222921365 0.592081558873807 GO:0008970 phospholipase A1 activity 1/222 22/18639 0.0454545454545455 3.81633906633907 0.231837282348759 0.592081558873807 GO:0015377 chloride:monoatomic cation symporter activity 1/222 22/18639 0.0454545454545455 3.81633906633907 0.231837282348759 0.592081558873807 GO:0034062 5'-3' RNA polymerase activity 1/222 22/18639 0.0454545454545455 3.81633906633907 0.231837282348759 0.592081558873807 GO:0050321 tau-protein kinase activity 1/222 22/18639 0.0454545454545455 3.81633906633907 0.231837282348759 0.592081558873807 GO:0061133 endopeptidase activator activity 1/222 22/18639 0.0454545454545455 3.81633906633907 0.231837282348759 0.592081558873807 GO:0097747 RNA polymerase activity 1/222 22/18639 0.0454545454545455 3.81633906633907 0.231837282348759 0.592081558873807 GO:0140035 ubiquitin-like protein reader activity 1/222 22/18639 0.0454545454545455 3.81633906633907 0.231837282348759 0.592081558873807 GO:0003724 RNA helicase activity 2/222 77/18639 0.025974025974026 2.18076518076518 0.23352341607683 0.592081558873807 GO:0020037 heme binding 3/222 142/18639 0.0211267605633803 1.77379139703083 0.239660619991273 0.592081558873807 GO:0000295 adenine nucleotide transmembrane transporter activity 1/222 23/18639 0.0434782608695652 3.65041128084606 0.240997304012753 0.592081558873807 GO:0005212 structural constituent of eye lens 1/222 23/18639 0.0434782608695652 3.65041128084606 0.240997304012753 0.592081558873807 GO:0005283 amino acid:sodium symporter activity 1/222 23/18639 0.0434782608695652 3.65041128084606 0.240997304012753 0.592081558873807 GO:0043274 phospholipase binding 1/222 23/18639 0.0434782608695652 3.65041128084606 0.240997304012753 0.592081558873807 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/222 23/18639 0.0434782608695652 3.65041128084606 0.240997304012753 0.592081558873807 GO:0008186 ATP-dependent activity, acting on RNA 2/222 79/18639 0.0253164556962025 2.12555593568252 0.242332291457353 0.592081558873807 GO:0033293 monocarboxylic acid binding 2/222 79/18639 0.0253164556962025 2.12555593568252 0.242332291457353 0.592081558873807 GO:0048306 calcium-dependent protein binding 2/222 80/18639 0.025 2.09898648648649 0.246742478664574 0.592081558873807 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0004622 lysophospholipase activity 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0004806 triacylglycerol lipase activity 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0005540 hyaluronic acid binding 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0015295 solute:proton symporter activity 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0030215 semaphorin receptor binding 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0030552 cAMP binding 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0060229 lipase activator activity 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/222 24/18639 0.0416666666666667 3.49831081081081 0.250048582402803 0.592081558873807 GO:0035091 phosphatidylinositol binding 5/222 284/18639 0.0176056338028169 1.47815949752569 0.250991223973147 0.592081558873807 GO:0015101 organic cation transmembrane transporter activity 2/222 81/18639 0.0246913580246914 2.07307307307307 0.25115555052739 0.592081558873807 GO:0030971 receptor tyrosine kinase binding 2/222 81/18639 0.0246913580246914 2.07307307307307 0.25115555052739 0.592081558873807 GO:0019207 kinase regulator activity 5/222 287/18639 0.0174216027874564 1.46270835295226 0.257703550820404 0.593268794371888 GO:0001848 complement binding 1/222 25/18639 0.04 3.35837837837838 0.258992402693245 0.593268794371888 GO:0005537 D-mannose binding 1/222 25/18639 0.04 3.35837837837838 0.258992402693245 0.593268794371888 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/222 25/18639 0.04 3.35837837837838 0.258992402693245 0.593268794371888 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/222 25/18639 0.04 3.35837837837838 0.258992402693245 0.593268794371888 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/222 25/18639 0.04 3.35837837837838 0.258992402693245 0.593268794371888 GO:0004527 exonuclease activity 2/222 84/18639 0.0238095238095238 1.99903474903475 0.264405243689167 0.593268794371888 GO:0051117 ATPase binding 2/222 84/18639 0.0238095238095238 1.99903474903475 0.264405243689167 0.593268794371888 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/222 26/18639 0.0384615384615385 3.22920997920998 0.267830034937905 0.593268794371888 GO:0004529 DNA exonuclease activity 1/222 26/18639 0.0384615384615385 3.22920997920998 0.267830034937905 0.593268794371888 GO:0005160 transforming growth factor beta receptor binding 1/222 26/18639 0.0384615384615385 3.22920997920998 0.267830034937905 0.593268794371888 GO:0005227 calcium-activated cation channel activity 1/222 26/18639 0.0384615384615385 3.22920997920998 0.267830034937905 0.593268794371888 GO:0008143 poly(A) binding 1/222 26/18639 0.0384615384615385 3.22920997920998 0.267830034937905 0.593268794371888 GO:0015216 purine nucleotide transmembrane transporter activity 1/222 26/18639 0.0384615384615385 3.22920997920998 0.267830034937905 0.593268794371888 GO:0019865 immunoglobulin binding 1/222 26/18639 0.0384615384615385 3.22920997920998 0.267830034937905 0.593268794371888 GO:0070412 R-SMAD binding 1/222 26/18639 0.0384615384615385 3.22920997920998 0.267830034937905 0.593268794371888 GO:0046906 tetrapyrrole binding 3/222 152/18639 0.0197368421052632 1.65709459459459 0.27163137907715 0.595598270351498 GO:0005104 fibroblast growth factor receptor binding 1/222 27/18639 0.037037037037037 3.10960960960961 0.276562734247193 0.595598270351498 GO:0008320 protein transmembrane transporter activity 1/222 27/18639 0.037037037037037 3.10960960960961 0.276562734247193 0.595598270351498 GO:0008395 steroid hydroxylase activity 1/222 27/18639 0.037037037037037 3.10960960960961 0.276562734247193 0.595598270351498 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/222 27/18639 0.037037037037037 3.10960960960961 0.276562734247193 0.595598270351498 GO:0001664 G protein-coupled receptor binding 5/222 297/18639 0.0168350168350168 1.41345891345891 0.280374914360054 0.595598270351498 GO:0004197 cysteine-type endopeptidase activity 2/222 88/18639 0.0227272727272727 1.90816953316953 0.282071752607143 0.595598270351498 GO:0061134 peptidase regulator activity 4/222 226/18639 0.0176991150442478 1.48600813202583 0.283247886520163 0.595598270351498 GO:0016866 intramolecular transferase activity 1/222 28/18639 0.0357142857142857 2.99855212355212 0.285191740963136 0.595598270351498 GO:0045499 chemorepellent activity 1/222 28/18639 0.0357142857142857 2.99855212355212 0.285191740963136 0.595598270351498 GO:0046625 sphingolipid binding 1/222 28/18639 0.0357142857142857 2.99855212355212 0.285191740963136 0.595598270351498 GO:0050698 proteoglycan sulfotransferase activity 1/222 28/18639 0.0357142857142857 2.99855212355212 0.285191740963136 0.595598270351498 GO:0051019 mitogen-activated protein kinase binding 1/222 28/18639 0.0357142857142857 2.99855212355212 0.285191740963136 0.595598270351498 GO:0051537 2 iron, 2 sulfur cluster binding 1/222 28/18639 0.0357142857142857 2.99855212355212 0.285191740963136 0.595598270351498 GO:0051959 dynein light intermediate chain binding 1/222 28/18639 0.0357142857142857 2.99855212355212 0.285191740963136 0.595598270351498 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/222 28/18639 0.0357142857142857 2.99855212355212 0.285191740963136 0.595598270351498 GO:0004181 metallocarboxypeptidase activity 1/222 29/18639 0.0344827586206897 2.89515377446412 0.293718280832363 0.595598270351498 GO:0005416 amino acid:monoatomic cation symporter activity 1/222 29/18639 0.0344827586206897 2.89515377446412 0.293718280832363 0.595598270351498 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/222 29/18639 0.0344827586206897 2.89515377446412 0.293718280832363 0.595598270351498 GO:0051861 glycolipid binding 1/222 29/18639 0.0344827586206897 2.89515377446412 0.293718280832363 0.595598270351498 GO:0099106 ion channel regulator activity 3/222 160/18639 0.01875 1.57423986486486 0.297530947381864 0.595598270351498 GO:0004866 endopeptidase inhibitor activity 3/222 161/18639 0.0186335403726708 1.56446197750546 0.300780757010852 0.595598270351498 GO:0001965 G-protein alpha-subunit binding 1/222 30/18639 0.0333333333333333 2.79864864864865 0.302143565177081 0.595598270351498 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/222 30/18639 0.0333333333333333 2.79864864864865 0.302143565177081 0.595598270351498 GO:0015215 nucleotide transmembrane transporter activity 1/222 30/18639 0.0333333333333333 2.79864864864865 0.302143565177081 0.595598270351498 GO:0022839 monoatomic ion-gated channel activity 1/222 30/18639 0.0333333333333333 2.79864864864865 0.302143565177081 0.595598270351498 GO:0031624 ubiquitin conjugating enzyme binding 1/222 30/18639 0.0333333333333333 2.79864864864865 0.302143565177081 0.595598270351498 GO:0033612 receptor serine/threonine kinase binding 1/222 30/18639 0.0333333333333333 2.79864864864865 0.302143565177081 0.595598270351498 GO:0051721 protein phosphatase 2A binding 1/222 30/18639 0.0333333333333333 2.79864864864865 0.302143565177081 0.595598270351498 GO:0005164 tumor necrosis factor receptor binding 1/222 31/18639 0.032258064516129 2.70836965998256 0.310468791064055 0.595598270351498 GO:0140098 catalytic activity, acting on RNA 6/222 387/18639 0.0155038759689922 1.30169704588309 0.314706166785314 0.595598270351498 GO:0022884 macromolecule transmembrane transporter activity 1/222 32/18639 0.03125 2.62373310810811 0.318695141471609 0.595598270351498 GO:0030515 snoRNA binding 1/222 32/18639 0.03125 2.62373310810811 0.318695141471609 0.595598270351498 GO:0070717 poly-purine tract binding 1/222 32/18639 0.03125 2.62373310810811 0.318695141471609 0.595598270351498 GO:0071813 lipoprotein particle binding 1/222 32/18639 0.03125 2.62373310810811 0.318695141471609 0.595598270351498 GO:0071814 protein-lipid complex binding 1/222 32/18639 0.03125 2.62373310810811 0.318695141471609 0.595598270351498 GO:0016874 ligase activity 3/222 167/18639 0.0179640718562874 1.50825376274478 0.320310252717157 0.595598270351498 GO:0016247 channel regulator activity 3/222 168/18639 0.0178571428571429 1.49927606177606 0.32356797180847 0.595598270351498 GO:0030296 protein tyrosine kinase activator activity 1/222 33/18639 0.0303030303030303 2.54422604422604 0.326823785454697 0.595598270351498 GO:0071889 14-3-3 protein binding 1/222 33/18639 0.0303030303030303 2.54422604422604 0.326823785454697 0.595598270351498 GO:0030414 peptidase inhibitor activity 3/222 169/18639 0.0177514792899408 1.49040460578922 0.326825850269719 0.595598270351498 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 4/222 243/18639 0.0164609053497942 1.38204871538205 0.328769226580051 0.595598270351498 GO:0141108 transporter regulator activity 3/222 170/18639 0.0176470588235294 1.48163751987281 0.330083653739843 0.595598270351498 GO:0004676 3-phosphoinositide-dependent protein kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0004711 ribosomal protein S6 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0035175 histone H3S10 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0035979 histone H2AXS139 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0044022 histone H3S28 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0044023 histone H4S1 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0044024 histone H2AS1 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0044025 histone H2BS14 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0072354 histone H3T3 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0072371 histone H2AS121 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0072518 Rho-dependent protein serine/threonine kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0140823 histone H2BS36 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0140855 histone H3S57 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0140995 histone H2A kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0140997 histone H4 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0140998 histone H2B kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:1990244 histone H2AT120 kinase activity 4/222 245/18639 0.0163265306122449 1.3707666850524 0.33416400621791 0.595598270351498 GO:0008175 tRNA methyltransferase activity 1/222 34/18639 0.0294117647058824 2.46939586645469 0.334855878308027 0.595598270351498 GO:0019825 oxygen binding 1/222 34/18639 0.0294117647058824 2.46939586645469 0.334855878308027 0.595598270351498 GO:0030332 cyclin binding 1/222 34/18639 0.0294117647058824 2.46939586645469 0.334855878308027 0.595598270351498 GO:0051427 hormone receptor binding 1/222 34/18639 0.0294117647058824 2.46939586645469 0.334855878308027 0.595598270351498 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/222 34/18639 0.0294117647058824 2.46939586645469 0.334855878308027 0.595598270351498 GO:0004677 DNA-dependent protein kinase activity 4/222 246/18639 0.016260162601626 1.36519446275544 0.336863076246503 0.595598270351498 GO:0140857 histone H3T45 kinase activity 4/222 246/18639 0.016260162601626 1.36519446275544 0.336863076246503 0.595598270351498 GO:0035402 histone H3T11 kinase activity 4/222 247/18639 0.0161943319838057 1.35966735966736 0.33956308290303 0.59677703492239 GO:0035403 histone H3T6 kinase activity 4/222 247/18639 0.0161943319838057 1.35966735966736 0.33956308290303 0.59677703492239 GO:0000175 3'-5'-RNA exonuclease activity 1/222 35/18639 0.0285714285714286 2.3988416988417 0.342792561727302 0.598155843797871 GO:0005343 organic acid:sodium symporter activity 1/222 35/18639 0.0285714285714286 2.3988416988417 0.342792561727302 0.598155843797871 GO:0015171 amino acid transmembrane transporter activity 2/222 102/18639 0.0196078431372549 1.64626391096979 0.343404632640345 0.598155843797871 GO:0004252 serine-type endopeptidase activity 3/222 176/18639 0.0170454545454545 1.43112714987715 0.349616123790113 0.603585700438564 GO:0004033 aldo-keto reductase (NADPH) activity 1/222 36/18639 0.0277777777777778 2.33220720720721 0.350634963968569 0.603585700438564 GO:0004190 aspartic-type endopeptidase activity 1/222 36/18639 0.0277777777777778 2.33220720720721 0.350634963968569 0.603585700438564 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/222 36/18639 0.0277777777777778 2.33220720720721 0.350634963968569 0.603585700438564 GO:0030551 cyclic nucleotide binding 1/222 37/18639 0.027027027027027 2.26917457998539 0.358384200005713 0.611545131986493 GO:0043394 proteoglycan binding 1/222 37/18639 0.027027027027027 2.26917457998539 0.358384200005713 0.611545131986493 GO:0070001 aspartic-type peptidase activity 1/222 37/18639 0.027027027027027 2.26917457998539 0.358384200005713 0.611545131986493 GO:0019888 protein phosphatase regulator activity 2/222 107/18639 0.0186915887850467 1.56933569083102 0.364944243927643 0.615662708251422 GO:0005501 retinoid binding 1/222 38/18639 0.0263157894736842 2.20945945945946 0.366041371686109 0.615662708251422 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/222 38/18639 0.0263157894736842 2.20945945945946 0.366041371686109 0.615662708251422 GO:0019840 isoprenoid binding 1/222 38/18639 0.0263157894736842 2.20945945945946 0.366041371686109 0.615662708251422 GO:0043531 ADP binding 1/222 38/18639 0.0263157894736842 2.20945945945946 0.366041371686109 0.615662708251422 GO:0004620 phospholipase activity 2/222 109/18639 0.018348623853211 1.54054054054054 0.373486147494903 0.623033074852793 GO:0000217 DNA secondary structure binding 1/222 39/18639 0.0256410256410256 2.15280665280665 0.373607567884468 0.623033074852793 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/222 39/18639 0.0256410256410256 2.15280665280665 0.373607567884468 0.623033074852793 GO:0004222 metalloendopeptidase activity 2/222 110/18639 0.0181818181818182 1.52653562653563 0.377739844482057 0.624849800425739 GO:0005543 phospholipid binding 7/222 497/18639 0.0140845070422535 1.18252759802056 0.380480900697788 0.624849800425739 GO:0004532 RNA exonuclease activity 1/222 40/18639 0.025 2.09898648648649 0.38108386465488 0.624849800425739 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/222 40/18639 0.025 2.09898648648649 0.38108386465488 0.624849800425739 GO:0071855 neuropeptide receptor binding 1/222 40/18639 0.025 2.09898648648649 0.38108386465488 0.624849800425739 GO:0071949 FAD binding 1/222 40/18639 0.025 2.09898648648649 0.38108386465488 0.624849800425739 GO:0005261 monoatomic cation channel activity 5/222 341/18639 0.0146627565982405 1.23107711817389 0.383327925098981 0.626778529340117 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/222 41/18639 0.024390243902439 2.04779169413316 0.388471325381081 0.629924497233963 GO:0042169 SH2 domain binding 1/222 41/18639 0.024390243902439 2.04779169413316 0.388471325381081 0.629924497233963 GO:0140318 protein transporter activity 1/222 41/18639 0.024390243902439 2.04779169413316 0.388471325381081 0.629924497233963 GO:0035198 miRNA binding 1/222 42/18639 0.0238095238095238 1.99903474903475 0.395771000924978 0.638235103140006 GO:0042056 chemoattractant activity 1/222 42/18639 0.0238095238095238 1.99903474903475 0.395771000924978 0.638235103140006 GO:0001221 transcription coregulator binding 2/222 115/18639 0.0173913043478261 1.46016451233843 0.398822931846339 0.639354633391125 GO:0017124 SH3 domain binding 2/222 115/18639 0.0173913043478261 1.46016451233843 0.398822931846339 0.639354633391125 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/222 43/18639 0.0232558139534884 1.95254556882464 0.40298392977343 0.639354633391125 GO:0005245 voltage-gated calcium channel activity 1/222 43/18639 0.0232558139534884 1.95254556882464 0.40298392977343 0.639354633391125 GO:0008200 ion channel inhibitor activity 1/222 43/18639 0.0232558139534884 1.95254556882464 0.40298392977343 0.639354633391125 GO:0015294 solute:monoatomic cation symporter activity 2/222 116/18639 0.0172413793103448 1.44757688723206 0.403000365169874 0.639354633391125 GO:0019208 phosphatase regulator activity 2/222 117/18639 0.0170940170940171 1.43520443520444 0.40716407665712 0.640253292855341 GO:1990782 protein tyrosine kinase binding 2/222 117/18639 0.0170940170940171 1.43520443520444 0.40716407665712 0.640253292855341 GO:0008236 serine-type peptidase activity 3/222 194/18639 0.0154639175257732 1.29834215658958 0.40768742401811 0.640253292855341 GO:0016248 channel inhibitor activity 1/222 44/18639 0.0227272727272727 1.90816953316953 0.410111138183319 0.640253292855341 GO:0019205 nucleobase-containing compound kinase activity 1/222 44/18639 0.0227272727272727 1.90816953316953 0.410111138183319 0.640253292855341 GO:0043014 alpha-tubulin binding 1/222 44/18639 0.0227272727272727 1.90816953316953 0.410111138183319 0.640253292855341 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/222 45/18639 0.0222222222222222 1.86576576576577 0.417153640324933 0.647802081668612 GO:0141110 transporter inhibitor activity 1/222 45/18639 0.0222222222222222 1.86576576576577 0.417153640324933 0.647802081668612 GO:0017171 serine hydrolase activity 3/222 198/18639 0.0151515151515152 1.27211302211302 0.420406705015705 0.650647277283069 GO:0004180 carboxypeptidase activity 1/222 46/18639 0.0217391304347826 1.82520564042303 0.424112438423667 0.650647277283069 GO:0030291 protein serine/threonine kinase inhibitor activity 1/222 46/18639 0.0217391304347826 1.82520564042303 0.424112438423667 0.650647277283069 GO:0016829 lyase activity 3/222 200/18639 0.015 1.25939189189189 0.426732862773465 0.650647277283069 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/222 122/18639 0.0163934426229508 1.37638458130261 0.427767779696908 0.650647277283069 GO:0030246 carbohydrate binding 4/222 280/18639 0.0142857142857143 1.19942084942085 0.4283490148704 0.650647277283069 GO:0001784 phosphotyrosine residue binding 1/222 47/18639 0.0212765957446809 1.78637147786084 0.43098852290008 0.650647277283069 GO:0005504 fatty acid binding 1/222 47/18639 0.0212765957446809 1.78637147786084 0.43098852290008 0.650647277283069 GO:0043495 protein-membrane adaptor activity 1/222 47/18639 0.0212765957446809 1.78637147786084 0.43098852290008 0.650647277283069 GO:0032266 phosphatidylinositol-3-phosphate binding 1/222 48/18639 0.0208333333333333 1.74915540540541 0.437782872508308 0.650647277283069 GO:0140693 molecular condensate scaffold activity 1/222 48/18639 0.0208333333333333 1.74915540540541 0.437782872508308 0.650647277283069 GO:0005004 GPI-linked ephrin receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0005008 hepatocyte growth factor receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0005009 insulin receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0005011 macrophage colony-stimulating factor receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0005020 stem cell factor receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0008288 boss receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0036332 placental growth factor receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0038062 protein tyrosine kinase collagen receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0060175 brain-derived neurotrophic factor receptor activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0060590 ATPase regulator activity 1/222 49/18639 0.0204081632653061 1.7134583563155 0.444496454472869 0.650647277283069 GO:0005006 epidermal growth factor receptor activity 1/222 50/18639 0.02 1.67918918918919 0.451130224623866 0.650647277283069 GO:0005007 fibroblast growth factor receptor activity 1/222 50/18639 0.02 1.67918918918919 0.451130224623866 0.650647277283069 GO:0005017 platelet-derived growth factor receptor activity 1/222 50/18639 0.02 1.67918918918919 0.451130224623866 0.650647277283069 GO:0005019 platelet-derived growth factor beta-receptor activity 1/222 50/18639 0.02 1.67918918918919 0.451130224623866 0.650647277283069 GO:0015605 organophosphate ester transmembrane transporter activity 1/222 50/18639 0.02 1.67918918918919 0.451130224623866 0.650647277283069 GO:0032813 tumor necrosis factor receptor superfamily binding 1/222 50/18639 0.02 1.67918918918919 0.451130224623866 0.650647277283069 GO:0048020 CCR chemokine receptor binding 1/222 50/18639 0.02 1.67918918918919 0.451130224623866 0.650647277283069 GO:0005010 insulin-like growth factor receptor activity 1/222 51/18639 0.0196078431372549 1.64626391096979 0.457685127530612 0.653676812312577 GO:0005021 vascular endothelial growth factor receptor activity 1/222 51/18639 0.0196078431372549 1.64626391096979 0.457685127530612 0.653676812312577 GO:0005030 neurotrophin receptor activity 1/222 51/18639 0.0196078431372549 1.64626391096979 0.457685127530612 0.653676812312577 GO:0030544 Hsp70 protein binding 1/222 51/18639 0.0196078431372549 1.64626391096979 0.457685127530612 0.653676812312577 GO:0016298 lipase activity 2/222 130/18639 0.0153846153846154 1.29168399168399 0.459933353844641 0.65454958748444 GO:0005262 calcium channel activity 2/222 131/18639 0.0152671755725191 1.28182380854137 0.463880559249144 0.65454958748444 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/222 52/18639 0.0192307692307692 1.61460498960499 0.4641620966337 0.65454958748444 GO:0005179 hormone activity 2/222 132/18639 0.0151515151515152 1.27211302211302 0.467810847402842 0.65454958748444 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2/222 132/18639 0.0151515151515152 1.27211302211302 0.467810847402842 0.65454958748444 GO:0005525 GTP binding 5/222 378/18639 0.0132275132275132 1.11057486057486 0.469837014699597 0.65454958748444 GO:0005003 ephrin receptor activity 1/222 53/18639 0.0188679245283019 1.5841407445181 0.470562054375526 0.65454958748444 GO:0005005 transmembrane-ephrin receptor activity 1/222 53/18639 0.0188679245283019 1.5841407445181 0.470562054375526 0.65454958748444 GO:0008146 sulfotransferase activity 1/222 53/18639 0.0188679245283019 1.5841407445181 0.470562054375526 0.65454958748444 GO:0038064 collagen receptor activity 1/222 53/18639 0.0188679245283019 1.5841407445181 0.470562054375526 0.65454958748444 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/222 53/18639 0.0188679245283019 1.5841407445181 0.470562054375526 0.65454958748444 GO:0051087 protein-folding chaperone binding 2/222 134/18639 0.0149253731343284 1.25312626058895 0.475620045754446 0.657117442575804 GO:0017069 snRNA binding 1/222 54/18639 0.0185185185185185 1.5548048048048 0.476885912329289 0.657117442575804 GO:0051287 NAD binding 1/222 54/18639 0.0185185185185185 1.5548048048048 0.476885912329289 0.657117442575804 GO:0140463 chromatin-protein adaptor activity 1/222 54/18639 0.0185185185185185 1.5548048048048 0.476885912329289 0.657117442575804 GO:0098632 cell-cell adhesion mediator activity 1/222 55/18639 0.0181818181818182 1.52653562653563 0.483134571326485 0.664168602736877 GO:0170055 lipid transmembrane transporter activity 1/222 56/18639 0.0178571428571429 1.49927606177606 0.489308921582916 0.671084899460682 GO:0140101 catalytic activity, acting on a tRNA 2/222 139/18639 0.0143884892086331 1.2080497763951 0.494836658695578 0.673161059576924 GO:0004601 peroxidase activity 1/222 57/18639 0.0175438596491228 1.47297297297297 0.495409842823222 0.673161059576924 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/222 57/18639 0.0175438596491228 1.47297297297297 0.495409842823222 0.673161059576924 GO:0016504 peptidase activator activity 1/222 57/18639 0.0175438596491228 1.47297297297297 0.495409842823222 0.673161059576924 GO:0008408 3'-5' exonuclease activity 1/222 58/18639 0.0172413793103448 1.44757688723206 0.501438204403958 0.67821250226987 GO:0061980 regulatory RNA binding 1/222 58/18639 0.0172413793103448 1.44757688723206 0.501438204403958 0.67821250226987 GO:0001786 phosphatidylserine binding 1/222 59/18639 0.0169491525423729 1.42304168575355 0.507394865435244 0.67845281551364 GO:0015459 potassium channel regulator activity 1/222 59/18639 0.0169491525423729 1.42304168575355 0.507394865435244 0.67845281551364 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1/222 59/18639 0.0169491525423729 1.42304168575355 0.507394865435244 0.67845281551364 GO:0045309 protein phosphorylated amino acid binding 1/222 59/18639 0.0169491525423729 1.42304168575355 0.507394865435244 0.67845281551364 GO:0070888 E-box binding 1/222 59/18639 0.0169491525423729 1.42304168575355 0.507394865435244 0.67845281551364 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/222 60/18639 0.0166666666666667 1.39932432432432 0.51328067490098 0.682092813929869 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/222 60/18639 0.0166666666666667 1.39932432432432 0.51328067490098 0.682092813929869 GO:0019903 protein phosphatase binding 2/222 144/18639 0.0138888888888889 1.1661036036036 0.513603106911417 0.682092813929869 GO:0019001 guanyl nucleotide binding 5/222 400/18639 0.0125 1.04949324324324 0.519548882007005 0.68688106697773 GO:0032561 guanyl ribonucleotide binding 5/222 400/18639 0.0125 1.04949324324324 0.519548882007005 0.68688106697773 GO:0015293 symporter activity 2/222 146/18639 0.0136986301369863 1.15012958163643 0.520980667664718 0.687226184088067 GO:0015085 calcium ion transmembrane transporter activity 2/222 147/18639 0.0136054421768707 1.142305570877 0.52464144145242 0.689223469763154 GO:0015179 L-amino acid transmembrane transporter activity 1/222 62/18639 0.0161290322580645 1.35418482999128 0.524843085151839 0.689223469763154 GO:0019842 vitamin binding 2/222 150/18639 0.0133333333333333 1.11945945945946 0.535510811086015 0.69856375900366 GO:0004536 DNA nuclease activity 1/222 64/18639 0.015625 1.31186655405405 0.536132028983907 0.69856375900366 GO:0000510 H3-H4 histone complex chaperone activity 2/222 151/18639 0.0132450331125828 1.11204582065509 0.539096052519009 0.69856375900366 GO:0140584 chromatin extrusion motor activity 2/222 151/18639 0.0132450331125828 1.11204582065509 0.539096052519009 0.69856375900366 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/222 151/18639 0.0132450331125828 1.11204582065509 0.539096052519009 0.69856375900366 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/222 151/18639 0.0132450331125828 1.11204582065509 0.539096052519009 0.69856375900366 GO:0015616 DNA translocase activity 2/222 152/18639 0.0131578947368421 1.10472972972973 0.5426622481649 0.700093933346806 GO:0140674 ATP-dependent histone chaperone activity 2/222 152/18639 0.0131578947368421 1.10472972972973 0.5426622481649 0.700093933346806 GO:0061775 cohesin loader activity 2/222 153/18639 0.0130718954248366 1.09750927397986 0.546209341315108 0.702799488197442 GO:0008235 metalloexopeptidase activity 1/222 66/18639 0.0151515151515152 1.27211302211302 0.547153945666492 0.702799488197442 GO:0005506 iron ion binding 2/222 154/18639 0.012987012987013 1.09038259038259 0.549737279289756 0.704458589667648 GO:0008173 RNA methyltransferase activity 1/222 67/18639 0.0149253731343284 1.25312626058895 0.55256673972572 0.704458589667648 GO:0016500 protein-hormone receptor activity 1/222 67/18639 0.0149253731343284 1.25312626058895 0.55256673972572 0.704458589667648 GO:0004386 helicase activity 2/222 155/18639 0.0129032258064516 1.08334786399303 0.553246013350572 0.704458589667648 GO:0140658 ATP-dependent chromatin remodeler activity 2/222 158/18639 0.0126582278481013 1.06277796784126 0.563656562003714 0.716161043065325 GO:0016782 transferase activity, transferring sulphur-containing groups 1/222 70/18639 0.0142857142857143 1.19942084942085 0.56842170342629 0.72065559376076 GO:0003689 DNA clamp loader activity 2/222 160/18639 0.0125 1.04949324324324 0.570500184354853 0.721731914259264 GO:0042379 chemokine receptor binding 1/222 72/18639 0.0138888888888889 1.1661036036036 0.578679682294723 0.730505319369897 GO:0043539 protein serine/threonine kinase activator activity 1/222 73/18639 0.0136986301369863 1.15012958163643 0.583717281827796 0.734006728088909 GO:0140713 histone chaperone activity 2/222 164/18639 0.0121951219512195 1.02389584706658 0.583954245345009 0.734006728088909 GO:0019003 GDP binding 1/222 75/18639 0.0133333333333333 1.11945945945946 0.593613296606102 0.744553429717483 GO:0051536 iron-sulfur cluster binding 1/222 76/18639 0.0131578947368421 1.10472972972973 0.598473124668667 0.747454732298952 GO:0098631 cell adhesion mediator activity 1/222 76/18639 0.0131578947368421 1.10472972972973 0.598473124668667 0.747454732298952 GO:0051540 metal cluster binding 1/222 77/18639 0.012987012987013 1.09038259038259 0.603275094518559 0.751204893659306 GO:0019199 transmembrane receptor protein kinase activity 1/222 78/18639 0.0128205128205128 1.07640332640333 0.608019891901216 0.751204893659306 GO:0015370 solute:sodium symporter activity 1/222 79/18639 0.0126582278481013 1.06277796784126 0.612708194471009 0.751204893659306 GO:0140030 modification-dependent protein binding 2/222 173/18639 0.0115606936416185 0.970629589126699 0.613085237042884 0.751204893659306 GO:0000049 tRNA binding 1/222 80/18639 0.0125 1.04949324324324 0.617340671886281 0.751204893659306 GO:0005216 monoatomic ion channel activity 5/222 448/18639 0.0111607142857143 0.937047538610039 0.620288777988053 0.751204893659306 GO:0001618 virus receptor activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:0033192 calmodulin-dependent protein phosphatase activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:0140791 histone H2AXS140 phosphatase activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:1990439 MAP kinase serine/threonine phosphatase activity 1/222 81/18639 0.0123456790123457 1.03653653653654 0.621917985903267 0.751204893659306 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 1/222 82/18639 0.0121951219512195 1.02389584706658 0.626440790468925 0.751204893659306 GO:0033549 MAP kinase phosphatase activity 1/222 82/18639 0.0121951219512195 1.02389584706658 0.626440790468925 0.751204893659306 GO:0140272 exogenous protein binding 1/222 82/18639 0.0121951219512195 1.02389584706658 0.626440790468925 0.751204893659306 GO:0005096 GTPase activator activity 3/222 271/18639 0.011070110701107 0.929440510621322 0.629226060988388 0.751204893659306 GO:0042578 phosphoric ester hydrolase activity 4/222 363/18639 0.0110192837465565 0.925173106991289 0.630791789502149 0.751204893659306 GO:0001540 amyloid-beta binding 1/222 83/18639 0.0120481927710843 1.01155975252361 0.630909731812671 0.751204893659306 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 1/222 83/18639 0.0120481927710843 1.01155975252361 0.630909731812671 0.751204893659306 GO:0030165 PDZ domain binding 1/222 83/18639 0.0120481927710843 1.01155975252361 0.630909731812671 0.751204893659306 GO:0016791 phosphatase activity 3/222 273/18639 0.010989010989011 0.922631422631423 0.634171670168314 0.751887173974291 GO:0004860 protein kinase inhibitor activity 1/222 84/18639 0.0119047619047619 0.999517374517375 0.63532544853705 0.751887173974291 GO:0017018 myosin phosphatase activity 1/222 84/18639 0.0119047619047619 0.999517374517375 0.63532544853705 0.751887173974291 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/222 86/18639 0.0116279069767442 0.976272784412319 0.643999724940121 0.757570818717136 GO:0016209 antioxidant activity 1/222 86/18639 0.0116279069767442 0.976272784412319 0.643999724940121 0.757570818717136 GO:0050660 flavin adenine dinucleotide binding 1/222 86/18639 0.0116279069767442 0.976272784412319 0.643999724940121 0.757570818717136 GO:0008081 phosphoric diester hydrolase activity 1/222 87/18639 0.0114942528735632 0.965051258154706 0.648259524490775 0.76105668175217 GO:0008234 cysteine-type peptidase activity 2/222 187/18639 0.0106951871657754 0.897962133256251 0.655270968020878 0.762179669016726 GO:0031406 carboxylic acid binding 2/222 187/18639 0.0106951871657754 0.897962133256251 0.655270968020878 0.762179669016726 GO:0003727 single-stranded RNA binding 1/222 89/18639 0.0112359550561798 0.943364713027634 0.656627491279343 0.762179669016726 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/222 89/18639 0.0112359550561798 0.943364713027634 0.656627491279343 0.762179669016726 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 1/222 89/18639 0.0112359550561798 0.943364713027634 0.656627491279343 0.762179669016726 GO:0140597 protein carrier chaperone 2/222 188/18639 0.0106382978723404 0.89318573893042 0.65813989637757 0.762179669016726 GO:0019210 kinase inhibitor activity 1/222 90/18639 0.0111111111111111 0.932882882882883 0.660736854995569 0.762179669016726 GO:0140793 histone H2AXY142 phosphatase activity 1/222 90/18639 0.0111111111111111 0.932882882882883 0.660736854995569 0.762179669016726 GO:0043177 organic acid binding 2/222 189/18639 0.0105820105820106 0.888459888459888 0.660989776079095 0.762179669016726 GO:0019902 phosphatase binding 2/222 190/18639 0.0105263157894737 0.883783783783784 0.663820651652875 0.762179669016726 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 1/222 91/18639 0.010989010989011 0.922631422631423 0.664797258154282 0.762179669016726 GO:0072341 modified amino acid binding 1/222 91/18639 0.010989010989011 0.922631422631423 0.664797258154282 0.762179669016726 GO:0015291 secondary active transmembrane transporter activity 3/222 287/18639 0.0104529616724739 0.877625011771353 0.667506072273496 0.763793497903591 GO:0043178 alcohol binding 1/222 92/18639 0.0108695652173913 0.912602820211516 0.668809281482391 0.763795813677361 GO:0051219 phosphoprotein binding 1/222 93/18639 0.010752688172043 0.902789886660854 0.672773498849669 0.766831153057778 GO:0004896 cytokine receptor activity 1/222 96/18639 0.0104166666666667 0.874577702702703 0.684384952713393 0.777048292539191 GO:0016407 acetyltransferase activity 1/222 96/18639 0.0104166666666667 0.874577702702703 0.684384952713393 0.777048292539191 GO:0004725 protein tyrosine phosphatase activity 1/222 98/18639 0.0102040816326531 0.85672917815775 0.691897111793746 0.784061012785577 GO:0030695 GTPase regulator activity 5/222 489/18639 0.0102249488752556 0.85848118056707 0.695707804158074 0.786860271754893 GO:0060589 nucleoside-triphosphatase regulator activity 5/222 490/18639 0.0102040816326531 0.85672917815775 0.697412996157329 0.787271978354524 GO:0003714 transcription corepressor activity 2/222 204/18639 0.00980392156862745 0.823131955484897 0.701486044414591 0.790349919522773 GO:0008238 exopeptidase activity 1/222 102/18639 0.00980392156862745 0.823131955484897 0.706391583287123 0.794352221052761 GO:0004722 protein serine/threonine phosphatase activity 1/222 103/18639 0.00970873786407767 0.815140383101548 0.70990785175075 0.79677994068392 GO:0004518 nuclease activity 2/222 209/18639 0.00956937799043062 0.803439803439803 0.714066590115483 0.799918107629368 GO:0008094 ATP-dependent activity, acting on DNA 2/222 210/18639 0.00952380952380952 0.7996138996139 0.716528950000097 0.801147606952489 GO:0004497 monooxygenase activity 1/222 106/18639 0.00943396226415094 0.792070372259052 0.720207100266516 0.802204113579592 GO:0008013 beta-catenin binding 1/222 106/18639 0.00943396226415094 0.792070372259052 0.720207100266516 0.802204113579592 GO:0004843 cysteine-type deubiquitinase activity 1/222 108/18639 0.00925925925925926 0.777402402402402 0.726870204889266 0.80809244369318 GO:0101005 deubiquitinase activity 1/222 115/18639 0.00869565217391304 0.730082256169213 0.748971234494183 0.831089063606967 GO:0005085 guanyl-nucleotide exchange factor activity 2/222 230/18639 0.00869565217391304 0.730082256169213 0.762147109919335 0.841096254558663 GO:0003697 single-stranded DNA binding 1/222 121/18639 0.00826446280991736 0.693879830243467 0.766491929141193 0.841096254558663 GO:0004540 RNA nuclease activity 1/222 121/18639 0.00826446280991736 0.693879830243467 0.766491929141193 0.841096254558663 GO:0015108 chloride transmembrane transporter activity 1/222 121/18639 0.00826446280991736 0.693879830243467 0.766491929141193 0.841096254558663 GO:0051082 unfolded protein binding 1/222 121/18639 0.00826446280991736 0.693879830243467 0.766491929141193 0.841096254558663 GO:0140097 catalytic activity, acting on DNA 3/222 336/18639 0.00892857142857143 0.749638030888031 0.766586875960622 0.841096254558663 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/222 122/18639 0.00819672131147541 0.688192290651307 0.769291302277096 0.842488795590775 GO:0019783 ubiquitin-like protein peptidase activity 1/222 127/18639 0.0078740157480315 0.661098105979996 0.782794880380577 0.855680809652512 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 1/222 128/18639 0.0078125 0.655933277027027 0.785399652234267 0.856932334315084 GO:0035591 signaling adaptor activity 1/222 129/18639 0.00775193798449612 0.650848522941546 0.787973326114879 0.857093471580231 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 3/222 349/18639 0.00859598853868195 0.721714551227445 0.788467588847231 0.857093471580231 GO:0016798 hydrolase activity, acting on glycosyl bonds 1/222 130/18639 0.00769230769230769 0.645841995841996 0.790516271636353 0.857732072921514 GO:0033218 amide binding 2/222 247/18639 0.00809716599190283 0.67983367983368 0.795804810138311 0.861877165223595 GO:0015297 antiporter activity 1/222 135/18639 0.00740740740740741 0.621921921921922 0.80278270708131 0.865608694808995 GO:0016779 nucleotidyltransferase activity 1/222 136/18639 0.00735294117647059 0.617348966613673 0.805148803008026 0.865608694808995 GO:0099094 ligand-gated monoatomic cation channel activity 1/222 136/18639 0.00735294117647059 0.617348966613673 0.805148803008026 0.865608694808995 GO:0140789 histone phosphatase activity 1/222 136/18639 0.00735294117647059 0.617348966613673 0.805148803008026 0.865608694808995 GO:0140767 enzyme-substrate adaptor activity 1/222 139/18639 0.00719424460431655 0.60402488819755 0.812078866929126 0.871463061951366 GO:0046982 protein heterodimerization activity 3/222 369/18639 0.00813008130081301 0.682597231377719 0.818801369104788 0.8770737293148 GO:0022843 voltage-gated monoatomic cation channel activity 1/222 143/18639 0.00699300699300699 0.587129087129087 0.820938717913968 0.87724168231587 GO:0003730 mRNA 3'-UTR binding 2/222 262/18639 0.00763358778625954 0.640911904270683 0.821947061795108 0.87724168231587 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 2/222 268/18639 0.00746268656716418 0.626563130294474 0.831539181185577 0.885868419883727 GO:0008509 monoatomic anion transmembrane transporter activity 1/222 149/18639 0.00671140939597315 0.563486305097043 0.833454756767383 0.886300619968214 GO:0140297 DNA-binding transcription factor binding 4/222 488/18639 0.00819672131147541 0.688192290651307 0.836515470725731 0.887946801656427 GO:0003712 transcription coregulator activity 4/222 495/18639 0.00808080808080808 0.678460278460278 0.844501278466551 0.894805506245244 GO:0001217 DNA-binding transcription repressor activity 2/222 278/18639 0.00719424460431655 0.60402488819755 0.846498460147487 0.895305578570405 GO:0031267 small GTPase binding 2/222 283/18639 0.00706713780918728 0.593353070384873 0.853518450217251 0.901106709132242 GO:0015081 sodium ion transmembrane transporter activity 1/222 164/18639 0.00609756097560976 0.511947923533289 0.861064373687896 0.907441269936796 GO:0015103 inorganic anion transmembrane transporter activity 1/222 165/18639 0.00606060606060606 0.508845208845209 0.862733857262526 0.907571279951798 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/222 167/18639 0.00598802395209581 0.50275125424826 0.86601314737304 0.909391265667217 GO:0005201 extracellular matrix structural constituent 1/222 168/18639 0.00595238095238095 0.499758687258687 0.867623426784213 0.909455270575594 GO:0005244 voltage-gated monoatomic ion channel activity 1/222 173/18639 0.00578034682080925 0.485314794563349 0.875390375277531 0.91581235909779 GO:0004721 phosphoprotein phosphatase activity 1/222 175/18639 0.00571428571428571 0.47976833976834 0.87836858291662 0.91581235909779 GO:0022832 voltage-gated channel activity 1/222 175/18639 0.00571428571428571 0.47976833976834 0.87836858291662 0.91581235909779 GO:0043021 ribonucleoprotein complex binding 1/222 177/18639 0.00564971751412429 0.474347228584517 0.881275923484267 0.917074302311011 GO:0005319 lipid transporter activity 1/222 178/18639 0.00561797752808989 0.471682356513817 0.882703544813835 0.917074302311011 GO:0016853 isomerase activity 1/222 180/18639 0.00555555555555556 0.466441441441441 0.885507720203137 0.918168089400599 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/222 181/18639 0.00552486187845304 0.463864416903091 0.886884679199556 0.918168089400599 GO:0051020 GTPase binding 2/222 315/18639 0.00634920634920635 0.533075933075933 0.891937816288489 0.921773764368562 GO:0015276 ligand-gated monoatomic ion channel activity 1/222 186/18639 0.00537634408602151 0.451394943330427 0.89352607202091 0.921792274650745 GO:0022834 ligand-gated channel activity 1/222 188/18639 0.00531914893617021 0.44659286946521 0.89607261299675 0.922797585665074 GO:0046873 metal ion transmembrane transporter activity 3/222 450/18639 0.00666666666666667 0.55972972972973 0.906641526366689 0.932046542867332 GO:0008168 methyltransferase activity 1/222 204/18639 0.00490196078431373 0.411565977742448 0.914378552060838 0.938357010593902 GO:0016741 transferase activity, transferring one-carbon groups 1/222 215/18639 0.00465116279069767 0.390509113764928 0.925064334153538 0.947666255057813 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 3/222 484/18639 0.00619834710743802 0.5204098726826 0.930369993911795 0.951441091334884 GO:0001216 DNA-binding transcription activator activity 3/222 491/18639 0.00610997963340122 0.512990587328673 0.934512360349144 0.954015226999909 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 1/222 229/18639 0.00436681222707424 0.366635194146111 0.936765369304745 0.95465498573244 GO:0005125 cytokine activity 1/222 234/18639 0.00427350427350427 0.358801108801109 0.94048754147485 0.956787152245645 GO:0015631 tubulin binding 2/222 385/18639 0.00519480519480519 0.436153036153036 0.945750039959097 0.960476251653962 GO:0042393 histone binding 1/222 247/18639 0.00404858299595142 0.33991683991684 0.94917566200977 0.962290351640302 GO:0016887 ATP hydrolysis activity 2/222 417/18639 0.00479616306954436 0.402683258798367 0.960764733058716 0.972360169492184 GO:0008017 microtubule binding 1/222 276/18639 0.0036231884057971 0.304200940070505 0.964272092783219 0.974230152261187 GO:0022836 gated channel activity 1/222 318/18639 0.00314465408805031 0.264023457419684 0.978576187974996 0.986983199899179 GO:0061630 ubiquitin protein ligase activity 1/222 353/18639 0.0028328611898017 0.237845494219432 0.986023040241596 0.992788206898485 GO:0061659 ubiquitin-like protein ligase activity 1/222 372/18639 0.00268817204301075 0.225697471665214 0.988919184004126 0.993999248305518 GO:0004842 ubiquitin-protein transferase activity 1/222 449/18639 0.0022271714922049 0.186992114609041 0.995686625779935 0.997579814909156 GO:0019787 ubiquitin-like protein transferase activity 1/222 479/18639 0.00208768267223382 0.175280708683631 0.99701667976198 0.997579814909156 GO:0016755 aminoacyltransferase activity 1/222 496/18639 0.00201612903225806 0.16927310374891 0.997579814909156 0.997579814909156