category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	55/95	238/9376	22.8076072534277	RPS26/RPS18/RPL37A/RPL28/RPS29/RPL41/RPL37/RPS27/RPL36A/RPL27A/RPS8/RPL21/RPL23A/RPLP2/RPL27/RPS21/RPL38/RPL35/RPS12/RPL34/RPS23/RPS15/RPL35A/RPL26/RPL36/RPL32/RPS25/RPS14/RPL31/RPS16/UBA52/RPS28/RPL30/RPLP1/RPS15A/RPL13A/RPL29/RPS19/RPS11/TRAF3/RPL12/RPL17/RPS10/RPL39/RPL13/RPS2/FAU/JAK1/RPL23/NFKB1/RPL10A/RPS27A/RPS20/RPS17/PIK3CA	34.4763255726771
Genetic Information Processing	Translation	hsa03010	Ribosome	51/95	222/9376	22.6731152204836	RPS26/RPS18/RPL37A/RPL28/RPS29/RPL41/RPL37/RPS27/RPL36A/RPL27A/RPS8/RPL21/RPL23A/RPLP2/RPL27/RPS21/RPL38/RPL35/RPS12/RPL34/RPS23/RPS15/RPL35A/RPL26/RPL36/RPL32/RPS25/RPS14/RPL31/RPS16/UBA52/RPS28/RPL30/RPLP1/RPS15A/RPL13A/RPL29/RPS19/RPS11/RPL12/RPL17/RPS10/RPL39/RPL13/RPS2/FAU/RPL23/RPL10A/RPS27A/RPS20/RPS17	33.0630129732731
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/95	205/9376	5.29581514762516	MT-ND3/COX7C/ATP5F1E/COX6C/NFKB1/COX6B1/UQCR11/PIK3CA/UQCRB/MT-ND6/UQCRQ	6.29164519371126
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/95	138/9376	6.43661327231121	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCR11/UQCRB/MT-ND6/UQCRQ	6.50922164287039
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	12/95	268/9376	4.41916732128829	MT-ND3/UBA52/COX7C/ATP5F1E/COX6C/COX6B1/RPS27A/UQCR11/ITPR2/UQCRB/MT-ND6/UQCRQ	5.74547970114128
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	11/95	227/9376	4.78256434036633	MT-ND3/COX7C/ATP5F1E/COX6C/NFKB1/COX6B1/UQCR11/PIK3CA/UQCRB/MT-ND6/UQCRQ	5.83663443808192
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/95	87/9376	7.94095583787054	ATP1B3/COX7C/COX6C/COX6B1/UQCR11/UQCRB/UQCRQ	6.58028161721469
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	11/95	275/9376	3.94778947368421	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCR11/PIK3CA/ITPR2/UQCRB/MT-ND6/UQCRQ	5.01959072238694
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/95	157/9376	5.02903117666778	COX7C/COX6C/NFKB1/COX6B1/UQCR11/PIK3CA/UQCRB/UQCRQ	5.15060922317802
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	12/95	388/9376	3.05241454150841	MT-ND3/COX7C/ATP5F1E/COX6C/NFKB1/COX6B1/UQCR11/PIK3CA/ITPR2/UQCRB/MT-ND6/UQCRQ	4.17733657429193
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/95	235/9376	3.77979843225084	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCR11/UQCRB/MT-ND6/UQCRQ	4.36616794460083
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/95	196/9376	4.02835660580021	UBA52/TRAF3/HLA-B/JAK1/NFKB1/RPS27A/PIK3CA/ITPR2	4.33474709288781
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	13/95	480/9376	2.67298245614035	MT-ND3/UBA52/COX7C/ATP5F1E/COX6C/NFKB1/COX6B1/RPS27A/UQCR11/ITPR2/UQCRB/MT-ND6/UQCRQ	3.80684042802755
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/95	308/9376	2.88393711551606	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCR11/UQCRB/MT-ND6/UQCRQ	3.40123045613542
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/95	109/9376	4.52728150651859	TRAF3/JAK1/NFKB1/PIK3CA/CCL4L2	3.74743271063543
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/95	368/9376	2.4137299771167	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCR11/UQCRB/MT-ND6/UQCRQ	2.79915045217486
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/95	90/9376	4.38643274853801	NFKB1/CAMK4/PIK3CA/IGF1R	3.26587399698915
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/95	142/9376	3.47516679021497	JAK1/NFKB1/CAMK4/PIK3CA/ITPR2	3.00679459559386
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	6/95	205/9376	2.88862644415918	TRAF3/HLA-B/JAK1/NFKB1/REL/PIK3CA	2.76607979667819
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/95	105/9376	3.75979949874687	TRAF3/NFKB1/ERC1/CCL4L2	2.87712641912532
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/95	106/9376	3.72432969215492	ZEB1/NFKB1/PIK3CA/IGF1R	2.85379507294529
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/95	227/9376	2.60867145838164	HLA-B/JAK1/NFKB1/PIK3CA/ITPR2/CCL4L2	2.4822386055277
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/95	238/9376	2.48810260946484	NFKB1/RALGAPA1/PAK2/REL/PIK3CA/IGF1R	2.35258776688562
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/95	180/9376	2.74152046783626	TRAF3/HLA-B/JAK1/NFKB1/PIK3CA	2.38679659047512
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/95	76/9376	3.89584487534626	CAMK4/PIK3CA/IGF1R	2.56442894533945
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/95	77/9376	3.84524948735475	JAK1/NFKB1/PIK3CA	2.5362826276858
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/95	80/9376	3.70105263157895	JAK1/PIK3CA/IGF1R	2.45459608519275
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/95	136/9376	2.90278637770898	TRAF3/JAK1/NFKB1/PIK3CA	2.26138005098227
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/95	137/9376	2.88159815597388	NFKB1/CTSW/PIK3CA/ITPR2	2.24452647953613
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/95	201/9376	2.45509295627128	ZEB1/NFKB1/REL/IGF1R/ETV6	2.10977326748191
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/95	38/9376	5.19445983379501	ATP1B3/PIK3CA	2.62114446567672
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	5/95	205/9376	2.40718870346598	TRAF3/HLA-B/JAK1/NFKB1/PIK3CA	2.06096671727157
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/95	90/9376	3.28982456140351	JAK1/NFKB1/PIK3CA	2.20830562661648
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/95	91/9376	3.25367264314633	NFKB1/PIK3CA/IFITM1	2.18559973602557
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/95	214/9376	2.30595179537629	HLA-B/NFKB1/PAK2/PIK3CA/ITPR2	1.9551898960648
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/95	93/9376	3.18370118845501	TRAF3/NFKB1/PIK3CA	2.14111781013938
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/95	156/9376	2.5306342780027	TRAF3/JAK1/NFKB1/PIK3CA	1.95037592794176
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/95	157/9376	2.51451558833389	HLA-B/NFKB1/PIK3CA/ITPR2	1.93611754684187
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/95	98/9376	3.02126745435016	ATP1B3/CAMK4/ITPR2	2.0349778735701
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/95	163/9376	2.4219567323216	TRAF3/JAK1/NFKB1/PIK3CA	1.8528049524516
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/95	48/9376	4.11228070175439	ATP1B3/PIK3CA	2.1870321347609
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/95	105/9376	2.81984962406015	UBA52/TOMM7/RPS27A	1.89721660381351
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/95	105/9376	2.81984962406015	NFKB1/PIK3CA/ITPR2	1.89721660381351
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/95	169/9376	2.33597010277172	UBA52/RPS27A/PIK3CA/IGF1R	1.77309120076107
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/95	173/9376	2.28195923334347	TRAF3/JAK1/NFKB1/PIK3CA	1.72179962850178
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/95	110/9376	2.69167464114832	NFKB1/PIK3CA/IGF1R	1.80558146657989
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/95	115/9376	2.57464530892448	CAMK4/PIK3CA/ITPR2	1.7189085677059
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	5/95	253/9376	1.95048887039734	UBA52/NFKB1/RPS27A/PIK3CA/ITPR2	1.55055977637532
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/95	119/9376	2.48810260946484	TRAF3/NFKB1/PIK3CA	1.6528037197428
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/95	187/9376	2.11111736560653	TRAF3/JAK1/NFKB1/ITPR2	1.55273258574137
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/95	120/9376	2.46736842105263	NFKB1/CAMK4/PIK3CA	1.63669657287217
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/95	60/9376	3.28982456140351	IGF1R/ITPR2	1.80016846361752
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/95	122/9376	2.42691975841242	NFKB1/PAK2/PIK3CA	1.60496207256694
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/95	61/9376	3.23589301121657	ATP1B3/MT2A	1.77245231847971
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/95	62/9376	3.18370118845501	PIK3CA/IGF1R	1.74530363384716
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/95	65/9376	3.03676113360324	PIK3CA/ITPR2	1.66705016363158
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/95	67/9376	2.94611154752553	CAMK4/ITPR2	1.61734872428716
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/95	68/9376	2.90278637770898	NFKB1/PIK3CA	1.59318554408129
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/95	70/9376	2.81984962406015	PAK2/PIK3CA	1.5461550872105
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/95	71/9376	2.78013343217198	NFKB1/PIK3CA	1.52325845276125
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/95	138/9376	2.14553775743707	SMC1B/IGF1R/ITPR2	1.37154489200308
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/95	138/9376	2.14553775743707	NFKB1/FYB1/PIK3CA	1.37154489200308
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/95	72/9376	2.74152046783626	TRAF3/NFKB1	1.5007558153096
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	4/95	212/9376	1.86216484607746	FYB1/SIPA1L1/PIK3CA/IGF1R	1.2845936049901
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/95	73/9376	2.70396539293439	PIK3CA/IGF1R	1.4786341905969
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/95	75/9376	2.63185964912281	ATP1B3/ITPR2	1.43548502999728
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/95	144/9376	2.05614035087719	JAK1/PIK3CA/IGF1R	1.29212651425465
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/95	76/9376	2.59722991689751	ATP1B3/ITPR2	1.41443440776997
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/95	77/9376	2.5634996582365	NFKB1/PIK3CA	1.3937185611321
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/95	78/9376	2.5306342780027	JAK1/NFKB1	1.3733271941789
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	4/95	224/9376	1.76240601503759	HLA-B/JAK1/NFKB1/PIK3CA	1.16842911974584
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/95	149/9376	1.98714235252561	MT-ND3/ITPR2/MT-ND6	1.22883257005643
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/95	226/9376	1.74680950163018	ATP1B3/NFKB1/CAMK4/PIK3CA	1.14975038024011
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/95	83/9376	2.37818642993025	NFKB1/CCL4L2	1.27590723917304
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/95	23/9376	4.29107551487414	ATP1B3	1.59873452150672
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/95	158/9376	1.87395069953364	TFDP2/SMC1B/STAG1	1.1208491851239
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/95	86/9376	2.29522643818849	PAK2/PIK3CA	1.22077920776376
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/95	93/9376	2.12246745897001	JAK1/NFKB1	1.10057872405288
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/95	93/9376	2.12246745897001	ATP1B3/ITPR2	1.10057872405288
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/95	94/9376	2.09988801791713	TRAF3/NFKB1	1.08428055692848
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	5/95	333/9376	1.48190295558717	TRAF3/HLA-B/JAK1/NFKB1/PIK3CA	0.905890062956688
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/95	29/9376	3.4032667876588	SLC24A1	1.31133881650534
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/95	98/9376	2.01417830290011	PIK3CA/ITPR2	1.02105755565144
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/95	30/9376	3.28982456140351	NFKB1	1.27086670807622
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/95	99/9376	1.99383306751728	PIK3CA/IGF1R	1.00572053171758
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/95	99/9376	1.99383306751728	PIK3CA/ITPR2	1.00572053171758
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/95	31/9376	3.18370118845501	SEC62	1.23206737888443
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/95	101/9376	1.95435122459614	NFKB1/PIK3CA	0.975578043306648
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/95	102/9376	1.93519091847265	ATP1B3/ITPR2	0.960764340230554
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/95	103/9376	1.91640265712826	NFKB1/PIK3CA	0.946117066880401
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/95	103/9376	1.91640265712826	NFKB1/PIK3CA	0.946117066880401
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/95	184/9376	1.6091533180778	PAK2/PIK3CA/SSH2	0.844268473695602
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/95	109/9376	1.81091260260744	JAK1/NFKB1	0.861524776761278
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/95	109/9376	1.81091260260744	NFKB1/PIK3CA	0.861524776761278
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/95	110/9376	1.79444976076555	PIK3CA/IGF1R	0.847943055523603
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/95	193/9376	1.53411508044723	NFKB1/PIK3CA/CCL4L2	0.758527371707024
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/95	112/9376	1.76240601503759	JAK1/NFKB1	0.821194641224103
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/95	39/9376	2.5306342780027	HLA-B	0.969058763996002
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	3/95	203/9376	1.45854290899663	PAK2/PIK3CA/IGF1R	0.668224444326238
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	3/95	204/9376	1.45139318885449	PIK3CA/IGF1R/ITPR2	0.659459481585683
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/95	122/9376	1.61794650560828	PIK3CA/IGF1R	0.695050088506736
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/95	122/9376	1.61794650560828	ATP1B3/PIK3CA	0.695050088506736
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/95	122/9376	1.61794650560828	PIK3CA/ITPR2	0.695050088506736
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/95	44/9376	2.24306220095694	TDG	0.836145560671564
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/95	44/9376	2.24306220095694	HLA-B	0.836145560671564
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/95	125/9376	1.57911578947368	NFKB1/PIK3CA	0.659441275082237
Organismal Systems	Immune system	hsa04611	Platelet activation	2/95	126/9376	1.56658312447786	PIK3CA/ITPR2	0.647780836106975
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/95	45/9376	2.19321637426901	HLA-B	0.81172967138928
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/95	216/9376	1.37076023391813	TRAF3/NFKB1/PIK3CA	0.557727861969733
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/95	130/9376	1.51838056680162	NFKB1/PIK3CA	0.602134481966456
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/95	47/9376	2.09988801791713	PIK3CA	0.76476835267251
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/95	133/9376	1.48413138108429	PIK3CA/IGF1R	0.568895675833802
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/95	133/9376	1.48413138108429	HLA-B/PIK3CA	0.568895675833802
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/95	49/9376	2.01417830290011	NFKB1	0.720097695810566
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/95	52/9376	1.89797570850202	IGF1R	0.656924081414488
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/95	139/9376	1.42006815600151	PIK3CA/ITPR2	0.504791162680081
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/95	140/9376	1.40992481203008	CAMK4/ITPR2	0.494397557390487
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/95	53/9376	1.86216484607746	ATP1B3	0.636796192678739
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	3/95	232/9376	1.27622504537205	PAK2/PIK3CA/SSH2	0.431011632920589
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/95	142/9376	1.39006671608599	UBA52/RPS27A	0.473847054867172
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	2/95	142/9376	1.39006671608599	NFKB1/PIK3CA	0.473847054867172
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/95	54/9376	1.82768031189084	HLA-B	0.617099237567976
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/95	144/9376	1.37076023391813	TRAF3/NFKB1	0.453603660042883
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/95	144/9376	1.37076023391813	PIK3CA/ITPR2	0.453603660042883
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/95	56/9376	1.76240601503759	MGAT5	0.578925162019753
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/95	56/9376	1.76240601503759	NFKB1	0.578925162019753
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/95	148/9376	1.33371266002845	PIK3CA/IGF1R	0.413999486111495
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/95	59/9376	1.67279214986619	PIK3CA	0.524467918914527
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/95	59/9376	1.67279214986619	PIK3CA	0.524467918914527
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/95	60/9376	1.64491228070175	PIK3CA	0.507004234773061
NA	NA	hsa04518	Integrin signaling	2/95	154/9376	1.28174982911825	PIK3CA/IGF1R	0.356665840761693
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/95	154/9376	1.28174982911825	CAMK4/ITPR2	0.356665840761693
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/95	250/9376	1.18433684210526	HLA-B/IGF1R/RAB11FIP3	0.298876638417216
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/95	158/9376	1.24930046635576	PIK3CA/IGF1R	0.31972996270267
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/95	65/9376	1.51838056680162	ITPR2	0.424284612688612
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/95	66/9376	1.49537480063796	NFKB1	0.408583752131508
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	4/95	362/9376	1.0905495783658	JAK1/NFKB1/PIK3CA/IGF1R	0.177759162444478
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/95	166/9376	1.18909321496512	ATP1B3/ITPR2	0.248685365683025
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/95	69/9376	1.43035850495805	PIK3CA	0.362994573789193
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/95	69/9376	1.43035850495805	ITPR2	0.362994573789193
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/95	69/9376	1.43035850495805	CAMK4	0.362994573789193
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/95	168/9376	1.1749373433584	JAK1/PIK3CA	0.231475252759065
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/95	70/9376	1.40992481203008	NFKB1	0.348274563521387
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/95	70/9376	1.40992481203008	HLA-B	0.348274563521387
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/95	71/9376	1.39006671608599	NFKB1	0.333779710936524
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/95	71/9376	1.39006671608599	PIK3CA	0.333779710936524
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/95	170/9376	1.16111455108359	PIK3CA/IGF1R	0.214473577221145
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/95	73/9376	1.3519826964672	SERINC5	0.305436748688079
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/95	73/9376	1.3519826964672	PIK3CA	0.305436748688079
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/95	75/9376	1.3159298245614	PIK3CA	0.277911482112658
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/95	78/9376	1.26531713900135	PIK3CA	0.23804983810225
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/95	78/9376	1.26531713900135	PIK3CA	0.23804983810225
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/95	78/9376	1.26531713900135	NFKB1	0.23804983810225
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/95	181/9376	1.0905495783658	JAK1/NFKB1	0.124451434689244
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/95	82/9376	1.20359435173299	HLA-B	0.187336055647037
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/95	85/9376	1.16111455108359	ADK	0.150960405205847
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/95	86/9376	1.14761321909425	ATP1B3	0.139128683099896
NA	NA	hsa04517	IgSF CAM signaling	3/95	299/9376	0.990248195740187	PAK2/ERC1/PIK3CA	-0.0173380182757476
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/95	87/9376	1.13442226255293	PIK3CA	0.127437252718907
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	3/95	300/9376	0.986947368421053	NFKB1/PAK2/IGF1R	-0.0232467110845628
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/95	195/9376	1.01225371120108	NFKB1/PIK3CA	0.0174940356428978
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/95	89/9376	1.10892962743938	ITPR2	0.104460801398942
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/95	90/9376	1.0966081871345	ATP1B3	0.0931688858711417
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	2/95	200/9376	0.986947368421053	NFKB1/PAK2	-0.0188771501294391
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/95	93/9376	1.061233729485	IGF1R	0.060039637966382
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/95	93/9376	1.061233729485	ITPR2	0.060039637966382
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/95	98/9376	1.00708915145005	PIK3CA	0.00713723773278916
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/95	99/9376	0.996916533758639	PIK3CA	-0.00312034828499086
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/95	100/9376	0.986947368421053	CCL4L2	-0.0132760159161947
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/95	323/9376	0.916669382434414	ZEB1/NFKB1/PIK3CA	-0.154191223974692
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/95	217/9376	0.909628910987145	NFKB1/PIK3CA	-0.136265341099863
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/95	103/9376	0.958201328564129	ATP1B3	-0.0431539958017269
NA	NA	hsa04081	Hormone signaling	2/95	219/9376	0.901321797644797	PIK3CA/IGF1R	-0.149491580700499
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/95	107/9376	0.922380718150516	ITPR2	-0.0816949332958714
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/95	115/9376	0.858215102974828	ITPR2	-0.154774712048854
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/95	115/9376	0.858215102974828	ITPR2	-0.154774712048854
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/95	116/9376	0.850816696914701	PIK3CA	-0.163566279197084
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/95	116/9376	0.850816696914701	ITPR2	-0.163566279197084
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	2/95	248/9376	0.795925297113752	NFKB1/PIK3CA	-0.329516565278455
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/95	250/9376	0.789557894736842	CTSW/BORCS7	-0.341202704159261
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/95	128/9376	0.771052631578947	ADK	-0.263855884841521
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/95	254/9376	0.777123912142561	CAMK4/ITPR2	-0.364321964299153
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/95	133/9376	0.742065690542145	ITPR2	-0.303094818954121
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/95	134/9376	0.736527886881382	ITPR2	-0.310780761299269
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/95	138/9376	0.715179252479024	PIK3CA	-0.34101402495269
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/95	149/9376	0.662380784175203	PIK3CA	-0.420281317705551
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/95	150/9376	0.657964912280702	PIK3CA	-0.427227912765316
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/95	154/9376	0.640874914559125	ATP1B3	-0.454614829539528
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	1/95	155/9376	0.636740237691002	HLA-B	-0.461364513413935
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/95	155/9376	0.636740237691002	ITPR2	-0.461364513413935
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/95	160/9376	0.616842105263158	HLA-B	-0.494557270882741
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/95	168/9376	0.587468671679198	JAK1	-0.545857114672523
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/95	174/9376	0.567211131276467	SEC62	-0.582988041514114
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/95	191/9376	0.516726370901075	CAMK4	-0.682684834541389
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/95	194/9376	0.508735756918068	BICDL1	-0.699515641874574
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/95	233/9376	0.4235825615541	ATP1B3	-0.901406667773853
NA	NA	hsa04519	Cadherin signaling	2/95	404/9376	0.488587806149036	NFKB1/IGF1R	-1.06308302499919
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/95	298/9376	0.331190392087602	CCL4L2	-1.1870406751769