category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	48/163	238/9376	11.6009692220446	RPL37A/RPS26/RPLP2/RPL27A/TRAF3/RPL21/RPL23A/RPL41/RPL37/RPS27/RPS12/RPL27/RPS15/RPL31/RPL28/RPS29/RPL36A/RPS23/RPL38/FAU/RPL32/RPS21/RPS16/RPL34/RPL26/UBA52/RPS25/RPL35A/RPS18/RPLP1/RPL29/RPL35/RPL36/RPS10/RPS11/RPS28/RPS8/RPS15A/RPL30/RPL17/RPS14/RPS19/RPL36AL/RPS2/JUN/RPL39/CCL2/NFKB1	22.0336973673892
Genetic Information Processing	Translation	hsa03010	Ribosome	44/163	222/9376	11.4006521859283	RPL37A/RPS26/RPLP2/RPL27A/RPL21/RPL23A/RPL41/RPL37/RPS27/RPS12/RPL27/RPS15/RPL31/RPL28/RPS29/RPL36A/RPS23/RPL38/FAU/RPL32/RPS21/RPS16/RPL34/RPL26/UBA52/RPS25/RPL35A/RPS18/RPLP1/RPL29/RPL35/RPL36/RPS10/RPS11/RPS28/RPS8/RPS15A/RPL30/RPL17/RPS14/RPS19/RPL36AL/RPS2/RPL39	20.8598178177217
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	20/163	227/9376	5.06797113591525	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/AKT3/NDUFB4/ATP5F1E/COX8A/CYBA/NDUFA1/NDUFB2/MT-CYB/ATP5MC2/JUN/NFE2L2/COX6C/PTPRJ/NFKB1	8.25244963255233
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/163	138/9376	6.25233395572153	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/NDUFB4/ATP5F1E/COX8A/ATP5MF/NDUFA1/NDUFB2/MT-CYB/ATP5MC2/COX6C	8.26764462701523
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/163	205/9376	4.77007332036511	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/AKT3/NDUFB4/ATP5F1E/COX8A/CYBA/NDUFA1/NDUFB2/MT-CYB/ATP5MC2/COX6C/NFKB1	7.25934246518625
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	14/163	157/9376	5.1293032706811	UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/AKT3/NDUFB4/COX8A/NDUFA1/NDUFB2/MT-CYB/JUN/COX6C/NFKB1	6.94006604949475
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/163	82/9376	7.01481370641927	HLA-B/HLA-A/CD74/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/CTSS/HLA-DQA2/PSME1	7.27623434094275
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/163	70/9376	7.39561787905346	HLA-B/HLA-A/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-DQA2/ITGAL/ACTG1	7.14379376973937
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/163	235/9376	3.91635556715833	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/NDUFB4/ATP5F1E/COX8A/ATP5MF/NDUFA1/NDUFB2/MT-CYB/ATP5MC2/COX6C/ACTG1	6.02221774607463
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	17/163	268/9376	3.64875011445838	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/UBA52/COX7A2/NDUFB4/ATP5F1E/COX8A/NDUFA1/NDUFB2/MT-CYB/ATP5MC2/NFE2L2/CALM1/COX6C	5.85161546944267
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/163	39/9376	10.3243668397043	HLA-B/HLA-A/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-DQA2	7.76116435035468
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	15/163	224/9376	3.85188431200701	HLA-B/HLA-A/HLA-F/HLA-DPB1/CD3E/AKT3/TLN1/NFATC1/LCK/HLA-DPA1/HLA-E/HLA-DQA2/JUN/ITGAL/NFKB1	5.74614806337476
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/163	44/9376	9.15114333519241	HLA-B/HLA-A/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-DQA2	7.20835900547669
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/163	45/9376	8.94778459441036	HLA-B/HLA-A/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-DQA2	7.10832302119809
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	14/163	205/9376	3.92829567559479	HLA-B/HLA-A/TRAF3/HLA-F/HLA-DPB1/CD3E/AKT3/NCOR2/HLA-DPA1/HLA-E/HLA-DQA2/JUN/ITGAL/NFKB1	5.63848480973518
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/163	54/9376	7.45648716200863	HLA-B/HLA-A/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-DQA2	6.32874397947668
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	12/163	180/9376	3.83476482617587	HLA-B/HLA-A/TRAF3/CD74/HLA-F/HLA-DPB1/AKT3/HLA-DPA1/HLA-E/HLA-DQA2/CCL2/NFKB1	5.10778621225249
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	15/163	275/9376	3.13753485778026	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/NDUFB4/ATP5F1E/COX8A/CYBA/NDUFA1/NDUFB2/MT-CYB/ATP5MC2/COX6C	4.78535212357896
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	13/163	214/9376	3.49429505188923	HLA-B/HLA-A/HLA-F/CD3E/AKT3/ELOB/NFATC1/TNFRSF1B/HLA-E/JUN/CALM1/NFKB1/APOBEC3C	4.9095136625484
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/163	160/9376	3.95460122699387	HLA-B/HLA-A/HLA-F/HLA-DPB1/SPN/HLA-DPA1/HLA-E/HLA-DQA2/SELL/CD6/ITGAL	5.01379458498526
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/163	87/9376	5.28933079472534	ATP1B3/UQCR11/COX6B1/COX7C/COX7A2/COX8A/MT-CYB/COX6C	5.3461801635107
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	18/163	388/9376	2.66852191512238	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/AKT3/NDUFB4/ATP5F1E/COX8A/AXIN1/NDUFA1/NDUFB2/MT-CYB/ATP5MC2/CALM1/COX6C/NFKB1	4.4647294910222
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/163	93/9376	4.94808364667854	HLA-DPB1/CD3E/NFATC1/LCK/HLA-DPA1/HLA-DQA2/JUN/NFKB1	5.08935270021116
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	17/163	368/9376	2.65724193118165	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/NDUFB4/TNFRSF1B/ATP5F1E/COX8A/NDUFA1/NDUFB2/MT-CYB/ATP5MC2/RANBP2/COX6C/ACTG1	4.31394435201845
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	20/163	480/9376	2.39672801635992	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/UBA52/COX7A2/NDUFB4/TNFRSF1B/ATP5F1E/COX8A/AXIN1/NDUFA1/NDUFB2/MT-CYB/HIP1/ATP5MC2/CALM1/COX6C/NFKB1	4.17843817792262
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	15/163	308/9376	2.80137040873237	MT-ND3/UQCR11/COX6B1/COX7C/NDUFA3/COX7A2/NDUFB4/ATP5F1E/COX8A/NDUFA1/NDUFB2/MT-CYB/HIP1/ATP5MC2/COX6C	4.27564394030837
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/163	155/9376	3.71106273500891	HLA-B/HLA-A/HLA-F/HLA-DPB1/HLA-DPA1/CYBA/HLA-E/CTSS/HLA-DQA2/ACTG1	4.52684172600799
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/163	109/9376	4.22175944166151	HLA-DPB1/CD3E/NFATC1/LCK/HLA-DPA1/HLA-DQA2/JUN/NFKB1	4.50003283029969
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	11/163	196/9376	3.22824589958683	HLA-B/HLA-A/TRAF3/HLA-F/UBA52/AKT3/NFATC1/HLA-E/JUN/CALM1/NFKB1	4.1932303056764
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/163	142/9376	3.64572712347706	AKT3/CYBA/JUN/NFE2L2/CALM1/MAP2K5/CCL2/ACTG1/NFKB1	4.2254521843861
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/163	66/9376	5.22922476296709	HLA-DPB1/NFATC1/HLA-DPA1/HLA-DQA2/JUN/NFKB1	4.58602901940998
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/163	95/9376	4.2384242815628	HLA-DPB1/HLA-DPA1/HLA-DQA2/LTB/JUN/CCL2/ITGAL	4.21965620375995
Human Diseases	Immune disease	hsa05310	Asthma	4/163	32/9376	7.19018404907975	HLA-DPB1/FCER1G/HLA-DPA1/HLA-DQA2	4.6654231597964
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/163	133/9376	3.45993818903086	HLA-B/HLA-A/HCST/NFATC1/LCK/FCER1G/HLA-E/ITGAL	3.80033991848677
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/163	78/9376	4.42472864558754	HLA-DPB1/HLA-DPA1/CYBA/HLA-DQA2/JUN/NFKB1	4.03977894744688
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/163	138/9376	3.33457810971815	ARPC1B/AKT3/NFATC1/LCK/JUN/CCL2/ACTG1/NFKB1	3.6748352880595
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	9/163	181/9376	2.86018371013117	CD74/HLA-DPB1/AKT3/FCER1G/HLA-DPA1/CTSS/HLA-DQA2/CALM1/NFKB1	3.36122946792254
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/163	119/9376	3.38361602309636	TRAF3/RHBDF2/AKT3/TNFRSF1B/JUN/CCL2/NFKB1	3.48059546361826
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/163	90/9376	3.83476482617587	CD3E/AKT3/NFATC1/LCK/JUN/NFKB1	3.59420509311673
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/163	157/9376	2.9310304403892	HLA-B/HLA-A/HLA-F/AKT3/NFATC1/HLA-E/CALM1/NFKB1	3.24545762841863
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/163	101/9376	3.41711717183988	AKT3/NFATC1/JUN/CCL2/PRKCE/NFKB1	3.24848103976769
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/163	105/9376	3.28694127957932	AKT3/NFATC1/FCER1G/JUN/CALM1/NFKB1	3.13447837133872
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/163	173/9376	2.65995248058442	TRAF3/HLA-DPB1/AKT3/HLA-DPA1/HLA-DQA2/CCL2/ACTG1/NFKB1	2.93111529073047
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/163	50/9376	4.60171779141104	HBA1/HBA2/CCL2/ITGAL	3.39645513791533
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	10/163	250/9376	2.30085889570552	HLA-B/HLA-A/HLA-F/GRK5/ARPC1B/ARRB1/HLA-E/CAPZB/SMAP1/DAB2	2.77292975562771
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	9/163	216/9376	2.39672801635992	TRAF3/AKT3/NFATC1/CYBA/JUN/NFE2L2/CALM1/CCL2/NFKB1	2.76229392388361
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/163	227/9376	2.28058701116186	HLA-B/HLA-A/HLA-F/AKT3/NFATC1/HLA-E/CALM1/CCL2/NFKB1	2.59785024441583
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/163	154/9376	2.61461238148355	CD38/NFATC1/JUN/CALM1/MAP2K5/RGS2/ACTG1	2.68716902530171
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/163	122/9376	2.82892487176908	CD3E/AKT3/NFATC1/LCK/JUN/NFKB1	2.7045183879933
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/163	91/9376	3.16052046113396	IFITM1/AKT3/NFATC1/JUN/NFKB1	2.75465383376226
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/163	205/9376	2.24474038605417	HLA-B/HLA-A/TRAF3/HLA-F/HLA-E/JUN/REL/NFKB1	2.39676949883305
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/163	100/9376	2.8760736196319	HLA-DPB1/CD38/CD3E/HLA-DPA1/HLA-DQA2	2.50869816131699
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/163	212/9376	2.17062159972219	RALGDS/AKT3/TLN1/SIPA1L1/EFNA5/CALM1/ITGAL/ACTG1	2.29308856306848
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/163	137/9376	2.51918857194035	AKT3/CTSW/CTSS/JUN/ACTG1/NFKB1	2.38253006464478
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/163	103/9376	2.79230448507952	CD3E/AKT3/JUN/CCL2/NFKB1	2.43275950947016
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/163	142/9376	2.43048474898471	AKT3/NFATC1/LCK/CYBA/JUN/NFKB1	2.28460632001411
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/163	73/9376	3.15186150096647	FEZ1/ELL2/RANBP2/APOBEC3C	2.45495276294794
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	5/163	112/9376	2.56792287467134	HLA-DPB1/AKT3/HLA-DPA1/HLA-DQA2/NFKB1	2.22030858983916
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/163	50/9376	3.45128834355828	HLA-DPB1/HLA-DPA1/HLA-DQA2	2.31158890595055
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/163	120/9376	2.39672801635992	AKT3/JUN/CALM1/MAP2K5/NFKB1	2.04818744387447
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/163	200/9376	2.01325153374233	ARPC1B/MYO1G/SEC24A/MYO1F/JUN/ACTG1/NFKB1	1.92656856586505
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/163	87/9376	2.64466539736267	RALGDS/AKT3/AXIN1/JUN	2.04989494720371
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/163	166/9376	2.07908936358933	ATP1B3/AKT3/NFATC1/CALM1/RGS2/PRKCE	1.86578048173266
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/163	253/9376	1.81886078711899	UBA52/ARPC1B/AKT3/TLN1/JUN/PRKCE/ACTG1/NFKB1	1.7562260004536
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	9/163	300/9376	1.72564417177914	PTPN7/AKT3/NFATC1/ARRB1/FLNA/EFNA5/JUN/MAP2K5/NFKB1	1.69908849834575
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/163	94/9376	2.44772222947396	TRAF3/JUN/CCL2/NFKB1	1.87632166215751
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/163	136/9376	2.11476001443522	TRAF3/CD3E/AKT3/JUN/NFKB1	1.74178183067786
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/163	61/9376	2.82892487176908	ATP1B3/MT2A/ATOX1	1.90611131183197
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/163	29/9376	3.966998096044	RASSF2/LATS2	2.12842842396666
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/163	99/9376	2.32409989465204	HLA-DPB1/HLA-DPA1/HLA-DQA2/ITGAL	1.76162504013154
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/163	226/9376	1.78163852543569	ATP1B3/AKT3/NFATC1/PDE4D/JUN/CALM1/NFKB1	1.58208034142842
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/163	187/9376	1.84560873987074	TRAF3/CARD16/CYBA/JUN/CCL2/NFKB1	1.55358509267977
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/163	105/9376	2.19129418638621	TRAF3/LCK/LTB/NFKB1	1.632786068655
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/163	233/9376	1.72811290449986	ATP1B3/SPTBN1/FMNL1/SYNE1/TLN1/CAPZB/ACTG1	1.49696357741457
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/163	149/9376	1.93025075143081	MT-ND3/NDUFA3/NDUFB4/NDUFA1/NDUFB2	1.52244568710129
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/163	238/9376	1.69180801154818	RALGDS/AKT3/RASA3/EFNA5/CALM1/REL/NFKB1	1.43789572854244
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/163	109/9376	2.11087972083075	TRAF3/AKT3/JUN/NFKB1	1.55163515612279
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/163	70/9376	2.46520595968449	AKT3/TNFRSF1B/NFKB1	1.63660953548528
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/163	70/9376	2.46520595968449	AKT3/ELOB/JUN	1.63660953548528
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/163	333/9376	1.55463438899022	HLA-B/HLA-A/TRAF3/HLA-F/AKT3/AXIN1/HLA-E/LLGL2/NFKB1	1.37072883811023
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/163	72/9376	2.39672801635992	TRAF3/NFKB1/ZNFX1	1.58242139717803
NA	NA	hsa04518	Integrin signaling	5/163	154/9376	1.86758027248825	AKT3/TLN1/FLNA/ITGAL/ACTG1	1.44389753350655
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/163	37/9376	3.10926877798043	HBA1/HBA2	1.70986374275564
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/163	38/9376	3.027445915402	CD3E/LCK	1.66568565672897
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/163	76/9376	2.2705844365515	ATP1B3/CALM1/ACTG1	1.4792710500908
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/163	77/9376	2.2410963269859	RALGDS/AKT3/NFKB1	1.45449299466344
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/163	78/9376	2.21236432279377	JUN/CALM1/NFKB1	1.43009399421125
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/163	163/9376	1.76446234333245	TRAF3/AKT3/NFATC1/JUN/NFKB1	1.30956864674448
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/163	125/9376	1.84068711656442	AKT3/FCER1G/PRKCE/NFKB1	1.25856011032704
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/163	170/9376	1.69180801154818	ARPC1B/JUN/LLGL2/PRKCE/ACTG1	1.21074718317672
Organismal Systems	Immune system	hsa04611	Platelet activation	4/163	126/9376	1.82607848865518	AKT3/TLN1/FCER1G/ACTG1	1.24169411889993
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/163	12/9376	4.79345603271984	COQ7	1.74893585028236
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/163	130/9376	1.76989145823502	AKT3/ARRB1/JUN/NFKB1	1.17571792007196
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/163	48/9376	2.39672801635992	ATP1B3/AKT3	1.2903784436533
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/163	49/9376	2.34781519969951	JUN/NFKB1	1.25816125267611
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/163	91/9376	1.89631227668037	GRK5/ARRB1/PDE4D	1.1427941061525
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/163	93/9376	1.85553136750445	ATP1B3/CD38/CALM1	1.10283906446287
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/163	93/9376	1.85553136750445	TRAF3/AKT3/NFKB1	1.10283906446287
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/163	98/9376	1.76086139977463	ARPC1B/AKT3/PRKCE	1.00709470014382
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/163	98/9376	1.76086139977463	ATP1B3/CALM1/PRKCE	1.00709470014382
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	5/163	193/9376	1.4901935853015	GRK5/AKT3/ARRB1/CCL2/NFKB1	0.915235571235653
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/163	99/9376	1.74307492098903	RALGDS/AKT3/JUN	0.988610748173225
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/163	195/9376	1.47490954852918	AKT3/CYBA/ITGAL/ACTG1/NFKB1	0.891378425455831
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	6/163	248/9376	1.39164852562834	ARPC1B/AKT3/FLNA/JUN/ACTG1/NFKB1	0.831406519077865
NA	NA	hsa04517	IgSF CAM signaling	7/163	299/9376	1.34665654430925	SPTBN1/ARPC1B/AKT3/LCK/ITGAL/CRTAM/ACTG1	0.810294208131336
NA	NA	hsa04519	Cadherin signaling	9/163	404/9376	1.28141893943996	ARPC1B/MYO1G/AXIN1/KRT72/RERE/MYO1F/LATS2/ACTG1/NFKB1	0.769091969958422
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/163	59/9376	1.94988042008943	RRM1/NME4	0.973499647364658
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/163	59/9376	1.94988042008943	AKT3/AXIN1	0.973499647364658
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/163	105/9376	1.64347063978966	TOMM7/UBA52/JUN	0.881939917313133
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/163	203/9376	1.41678503430143	AKT3/TLN1/FLNA/JUN/ACTG1	0.798515486248905
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/163	154/9376	1.4940642179906	ATP1B3/AKT3/CALM1/CREM	0.822261787608976
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/163	157/9376	1.4655152201946	AXIN1/LLGL2/LATS2/ACTG1	0.782385347701219
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/163	109/9376	1.58315979062307	AKT3/PRKCE/NFKB1	0.814535737578572
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/163	110/9376	1.56876742889013	AKT3/ELOB/NFKB1	0.798111957457002
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/163	65/9376	1.76989145823502	AKT3/ARRB1	0.828451180406876
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/163	116/9376	1.4876242860165	CYBA/ITGAL/ACTG1	0.702890596975324
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/163	68/9376	1.69180801154818	AKT3/NFKB1	0.761536565423402
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/163	23/9376	2.50093358228861	ATP1B3	0.958581030423052
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/163	69/9376	1.66728905485907	AKT3/FCER1G	0.739967413279396
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/163	69/9376	1.66728905485907	JUN/CALM1	0.739967413279396
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/163	170/9376	1.35344640923854	AKT3/AXIN1/NFE2L2/ACTG1	0.618573704331393
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/163	71/9376	1.6203231659898	AKT3/NFKB1	0.697859332415051
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/163	71/9376	1.6203231659898	JUN/NFKB1	0.697859332415051
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/163	122/9376	1.41446243588454	ATP1B3/AKT3/ACTG1	0.61288536029257
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/163	76/9376	1.513722957701	AKT3/CALM1	0.598099171713967
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/163	128/9376	1.34815950920245	RRM1/NME4/PDE4D	0.527519162818731
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/163	77/9376	1.4940642179906	AKT3/NFKB1	0.579014640810681
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/163	28/9376	2.05433829973707	SLC12A7	0.74315354113772
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/163	78/9376	1.47490954852918	ARPC1B/ACTG1	0.560199009799372
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/163	29/9376	1.983499048022	CALM1	0.70553039165925
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/163	133/9376	1.29747682088657	AKT3/ARRB1/CALM1	0.459569692556042
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/163	30/9376	1.91738241308793	NFKB1	0.669386661190053
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/163	134/9376	1.28779415804413	RAMP1/CALM1/PRKCE	0.446303503234586
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/163	82/9376	1.40296274128385	RRM1/NME4	0.48747167898497
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/163	32/9376	1.79754601226994	GALM	0.601095154384075
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/163	139/9376	1.24147062717924	AKT3/JUN/CALM1	0.381491743636303
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/163	85/9376	1.35344640923854	RRM1/NME4	0.435392267268728
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/163	194/9376	1.18600974005439	MYO1G/MYO1F/CAPZB/ACTG1	0.348214467762363
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/163	140/9376	1.23260297984224	AKT3/CALM1/PRKCE	0.368821504127327
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/163	86/9376	1.33770866029391	AKT3/JUN	0.418468210088196
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/163	143/9376	1.20674417606933	HLA-DPB1/HLA-DPA1/HLA-DQA2	0.33136664463664
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/163	144/9376	1.19836400817996	TRAF3/AKT3/NFKB1	0.319062032999391
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/163	201/9376	1.14470591826145	BCL11B/KLF3/REL/NFKB1	0.275841871409579
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/163	90/9376	1.27825494205862	AKT3/NFKB1	0.352800105566837
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/163	36/9376	1.59781867757328	MCM6	0.477998128922716
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/163	148/9376	1.16597579174266	AKT3/AXIN1/JUN	0.270707768316157
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/163	149/9376	1.15815045085848	RALGDS/AKT3/FCER1G	0.258828570094988
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/163	93/9376	1.23702091166964	PTPRJ/ACTG1	0.305536337313216
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/163	93/9376	1.23702091166964	JUN/CALM1	0.305536337313216
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/163	38/9376	1.513722957701	CD38	0.422058588924319
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/163	38/9376	1.513722957701	ATP1B3	0.422058588924319
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/163	156/9376	1.10618216139689	TRAF3/AKT3/NFKB1	0.17788007540218
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/163	99/9376	1.16204994732602	AKT3/JUN	0.21559645621491
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/163	99/9376	1.16204994732602	CALM1/PRKCE	0.21559645621491
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/163	158/9376	1.09217985555642	TFDP2/CDC14A/MCM6	0.155426518712359
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/163	100/9376	1.15042944785276	TNFRSF1B/CCL2	0.201155261332546
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/163	217/9376	1.06030363857397	AKT3/ARRB1/JUN/NFKB1	0.11954413102079
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/163	102/9376	1.12787200769878	ATP1B3/CD38	0.172711369919015
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/163	106/9376	1.08531079986109	AKT3/NFKB1	0.117488669113411
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/163	46/9376	1.25046679114431	PSME1	0.226499449407136
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/163	107/9376	1.07516770827361	AKT3/CALM1	0.1040125304561
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/163	47/9376	1.22386111473698	ME3	0.204639256519181
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/163	47/9376	1.22386111473698	PRKCE	0.204639256519181
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	4/163	232/9376	0.991749524011001	ARPC1B/AKT3/ITGAL/ACTG1	-0.0169251993757156
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/163	49/9376	1.17390759984976	ST6GAL1	0.162339617275162
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/163	51/9376	1.12787200769878	ACTG1	0.121790960813425
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/163	115/9376	1.00037343291544	ARRB1/PDE4D	0.000535934207703059
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/163	178/9376	0.96946301785345	NFATC1/AXIN1/JUN	-0.0547102020322008
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/163	53/9376	1.08531079986109	ATP1B3	0.0828405571987196
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/163	117/9376	0.983273032352787	BAZ1A/ACTG1	-0.0242162566397703
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/163	55/9376	1.04584495259342	CERK	0.0453545146236424
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/163	56/9376	1.02716914986854	ST6GAL1	0.0271232053212863
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/163	56/9376	1.02716914986854	ARRB1	0.0271232053212863
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/163	56/9376	1.02716914986854	NFKB1	0.0271232053212863
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/163	59/9376	0.974940210044713	RRM1	-0.0256829135210599
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/163	59/9376	0.974940210044713	AKT3	-0.0256829135210599
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/163	60/9376	0.958691206543967	AKT3	-0.0426955193208879
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/163	62/9376	0.927765683752226	AKT3	-0.0759014720864826
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/163	62/9376	0.927765683752226	NCOR2	-0.0759014720864826
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/163	63/9376	0.913039244327588	AXIN1	-0.0921144329799433
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/163	67/9376	0.85852943869609	GALM	-0.154572014733767
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/163	67/9376	0.85852943869609	CALM1	-0.154572014733767
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	3/163	204/9376	0.845904005774089	AKT3/FLNA/ACTG1	-0.295973831567448
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/163	138/9376	0.833644527429537	AKT3/CALM1	-0.26185843104541
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/163	69/9376	0.833644527429537	CALM1	-0.184474221218621
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/163	142/9376	0.810161582994902	UBA52/ELOB	-0.303188165815222
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/163	71/9376	0.810161582994902	AKT3	-0.213566924824609
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/163	144/9376	0.798909338786639	AKT3/AXIN1	-0.323447765411753
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/163	73/9376	0.787965375241617	AKT3	-0.241899856313909
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/163	73/9376	0.787965375241617	AKT3	-0.241899856313909
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/163	75/9376	0.766952965235174	AKT3	-0.26951832303933
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/163	75/9376	0.766952965235174	ATP1B3	-0.26951832303933
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/163	76/9376	0.7568614788505	ME3	-0.283072706662864
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/163	150/9376	0.766952965235174	AKT3/AXIN1	-0.382702580540557
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/163	154/9376	0.747032108995299	NME4/COQ7	-0.421009704186179
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/163	80/9376	0.719018404907976	AKT3	-0.335701834393631
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/163	298/9376	0.772100300572323	TNFRSF1B/LTB/TNFRSF9/CCL2	-0.531784531001342
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/163	83/9376	0.693029787863109	KDM2B	-0.373625248383471
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/163	83/9376	0.693029787863109	NFKB1	-0.373625248383471
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/163	86/9376	0.668854330146954	ATP1B3	-0.4103357480417
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/163	86/9376	0.668854330146954	ACTG1	-0.4103357480417
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/163	89/9376	0.646308678568967	MAP2K5	-0.445923734996011
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/163	90/9376	0.639127471029312	ATP1B3	-0.457551141320636
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/163	169/9376	0.680727483936545	UBA52/AKT3	-0.557089175921247
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/163	174/9376	0.661166349340667	SEC24A/NFE2L2	-0.600065902355092
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/163	250/9376	0.690257668711656	CTSW/CTSS/BORCS5	-0.660251261564479
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/163	97/9376	0.593004870027196	CALM1	-0.535924235577674
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/163	98/9376	0.586953799924878	CALM1	-0.546718021355019
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/163	254/9376	0.679387469204386	CD38/NFATC1/CALM1	-0.689019037326603
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/163	99/9376	0.581024973663011	ACTG1	-0.557417835743406
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/163	101/9376	0.569519528639981	CALM1	-0.578543591305848
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/163	184/9376	0.625233395572153	EPHA4/EFNA5	-0.682878897592985
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/163	103/9376	0.558460897015903	ATP1B3	-0.599316946718363
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/163	103/9376	0.558460897015903	NFKB1	-0.599316946718363
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/163	105/9376	0.547823546596553	ACTG1	-0.619752385370593
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/163	108/9376	0.53260622585776	RANBP2	-0.649801475465627
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/163	110/9376	0.522922476296709	EMP3	-0.669449861157795
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/163	110/9376	0.522922476296709	AKT3	-0.669449861157795
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/163	115/9376	0.500186716457722	AKT3	-0.717309655995812
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/163	116/9376	0.4958747620055	ME3	-0.726676048846941
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/163	122/9376	0.471487478628181	AKT3	-0.781536658174583
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/163	122/9376	0.471487478628181	AKT3	-0.781536658174583
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/163	133/9376	0.432492273628857	AKT3	-0.876738397816248
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/163	138/9376	0.416822263714768	CALM1	-0.917974050896228
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/163	144/9376	0.39945466939332	AKT3	-0.965957563822898
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/163	323/9376	0.53425516154153	EFNA5/PRKCE/NFKB1	-1.13300533907039
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/163	155/9376	0.371106273500891	AXIN1	-1.05010567464108
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/163	157/9376	0.36637880504865	NFATC1	-1.06491886283684
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/163	158/9376	0.364059951852139	AKT3	-1.07227275630624
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/163	168/9376	0.342389716622845	AKT3	-1.14398277742464
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	3/163	362/9376	0.476697285021862	AKT3/EFNA5/NFKB1	-1.35060203936235
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/163	191/9376	0.301159541322712	CALM1	-1.29787852995257
NA	NA	hsa04382	Cornified envelope formation	1/163	217/9376	0.265075909643493	KRT72	-1.45689155456419
NA	NA	hsa04081	Hormone signaling	1/163	219/9376	0.262655125080539	RAMP1	-1.46857124744682
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/163	449/9376	0.384330550507604	ARRB1/CALM1/RGS2	-1.77826676449016
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/163	243/9376	0.236713878159004	DDX46	-1.60347679320998
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/163	370/9376	0.155463438899022	P2RY8	-2.20461242655064