category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	81/1503	205/9376	2.46484591792026	MT-ND3/COL1A2/ATP5F1E/COL1A1/UQCR11/NDUFA3/NDUFA4L2/TGFB3/NDUFB3/COL3A1/NDUFB2/NDUFB4/RYR2/COX6C/COX7A2/MT-ND5/UQCRQ/NDUFB7/MT-ATP8/NDUFS6/PRKCG/PRKCD/COX8A/COX7A1/NDUFA2/NDUFA13/NDUFA4/NDUFS8/NDUFB11/NDUFA7/NDUFA11/ATP2A2/PTPA/NDUFA6/AKT1/GFPT1/TGFB1/TGFBR2/COX6B1/NDUFC1/ATP5MC1/COX6A1/ATP5MC3/UQCR10/NDUFB6/PPARA/ATP2A3/PARP1/COX7C/MTOR/TNNI3/TGFB2/CAMK2G/GSK3B/MT-ND6/TGFBR1/ATP5PB/NDUFB1/PPIF/PIK3R2/COX7B/SLC25A4/NFKB1/PIK3R1/GAPDH/GFPT2/MAPK9/G6PD/SLC25A5/PIK3R3/ATP5F1D/GYS1/COX5B/MPC2/NDUFV3/VDAC1/NDUFS1/MT-CO2/GSR/MT-CO3/AGER	9.2652156427219
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	86/1503	233/9376	2.30250800259281	COL1A2/ELN/LMNA/COL4A1/SYNPO2/COL4A2/FBN2/COL1A1/COL27A1/THBS1/ACTB/SSPN/ATP1B1/DAAM1/COL6A2/TPM4/COL6A3/PDLIM3/VIM/COL5A2/COL3A1/COL5A3/BGN/VCAN/ITGA1/ACTG2/FHL2/COMP/SDC2/DSP/MYL9/TLN1/COL5A1/PDLIM7/PDLIM2/FBLN2/NEBL/SGCD/COL6A1/THBS2/TPM2/NID2/ITGA11/VCL/SDC3/CSRP1/ACTG1/TPM1/MYH10/SYNE1/ITGA5/HSPG2/MYH9/TMOD3/ITGB1/TNNI3/ANK2/PDLIM1/FHL3/LMOD1/MYH13/ITGAV/ZYX/TNNC2/AMPD2/LMNB2/SPTBN1/FLNC/SNTB2/THBS3/SNTB1/DAG1/DAAM2/FMNL3/SGCB/FBN1/ATP1B3/DIAPH1/ENO1/FBLN1/TLN2/ITGA10/AGRN/ITGB3/TNNT1/LAMA2	8.7964817029378
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	83/1503	235/9376	2.20327571806741	MT-ND3/ATP5F1E/ACTB/UQCR11/NDUFA3/NDUFA4L2/NDUFB3/ATP5MF/CREB3L2/NDUFB2/NDUFB4/COX6C/COX7A2/MT-ND5/UQCRQ/NDUFB7/SMARCA4/MT-ATP8/NDUFS6/MAP3K5/COX8A/COX7A1/NDUFA2/NDUFA13/NDUFA4/ACTG1/MGLL/NDUFS8/NDUFB11/NDUFA7/NDUFA11/FGFR1/FRS2/NDUFA6/COX6B1/NDUFC1/ATP5MC1/COX6A1/PRKACA/ATP5MC3/SMARCD2/UQCR10/NDUFB6/COX17/ACSL4/MAP2K3/ADCY7/ADCY6/ATP5ME/COX7C/MTOR/MT-ND6/SMARCD1/ATP5PB/SMARCD3/NDUFB1/NDUFAF5/RPS6KA3/COX7B/ADCY5/TSC2/SMARCB1/CREB3/DPF1/PRKAG2/PRKACB/COA7/ATP5F1D/PRKAA1/ACSL1/COX5B/NDUFV3/NDUFS1/ACSL3/MT-CO2/COA3/CPT1A/MT-CO3/RPTOR/SIRT6/RPS6KB2/ATP5MGL/AKT1S1	8.16201206159338
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	88/1503	268/9376	2.04836098946386	MT-ND3/ATP5F1E/DUSP1/UQCR11/NDUFA3/NDUFA4L2/NDUFB3/CALM1/NDUFB2/NDUFB4/COX6C/COX7A2/MT-ND5/TUBB6/UQCRQ/NDUFB7/MT-ATP8/SLC39A4/NDUFS6/MAP3K5/COX8A/XBP1/COX7A1/NDUFA2/NDUFA13/NDUFA4/SLC39A13/TUBA1A/SLC39A3/NDUFS8/TUBB2A/NDUFB11/NDUFA7/NDUFA11/GNAI2/NDUFA6/SLC39A7/COX6B1/NDUFC1/ATP5MC1/COX6A1/PRKACA/ATP5MC3/UQCR10/PINK1/NDUFB6/PSMD14/TUBA1B/PSMD2/PSMC4/COX7C/UBE2J1/CAMK2G/PSMD1/MT-ND6/SLC39A11/TUBB4B/ATP5PB/ITPR2/NDUFB1/PPIF/EIF2AK3/COX7B/ADCY5/HSPA5/SLC25A4/TUBA1C/CYCS/KLC2/MAPK9/SLC25A5/GPR37/PRKACB/KEAP1/ATP5F1D/ATF6/COX5B/NDUFV3/VDAC1/NDUFS1/CASP3/UBA52/MT-CO2/ITPR1/MCU/UBE2G1/MT-CO3/APAF1	7.60784648966048
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	113/1503	388/9376	1.81679253177494	MT-ND3/ATP5F1E/UQCR11/NDUFA3/NDUFA4L2/NDUFB3/CALM1/NDUFB2/CAPN2/WIPI1/NDUFB4/CACNA1C/COX6C/COX7A2/MT-ND5/TUBB6/UQCRQ/NDUFB7/MT-ATP8/PTGS2/SLC39A4/NDUFS6/WNT2B/MAP3K5/COX8A/XBP1/COX7A1/NDUFA2/NDUFA13/PSENEN/ADAM17/WNT11/NDUFA4/CAPN1/SLC39A13/TUBA1A/SLC39A3/NDUFS8/TUBB2A/NDUFB11/NDUFA7/NDUFA11/ATP2A2/NDUFA6/AKT1/SLC39A7/COX6B1/NDUFC1/ATP5MC1/COX6A1/ATP5MC3/UQCR10/LRP5/NDUFB6/PSMD14/TUBA1B/ATP2A3/PSMD2/PSMC4/COX7C/ATG101/MTOR/IL6/MME/PSMD1/GSK3B/MT-ND6/SLC39A11/TUBB4B/ATP5PB/ITPR2/NDUFB1/PPIF/EIF2AK3/BACE1/PIK3R2/COX7B/MAP2K1/SLC25A4/TUBA1C/NFKB1/CYCS/PIK3R1/KLC2/GAPDH/MAPK9/SLC25A5/PIK3R3/FADD/PSEN2/ADAM10/LRP6/ATP5F1D/ATF6/RTN4/COX5B/NRBF2/NDUFV3/VDAC1/NDUFS1/CASP3/MT-CO2/ITPR1/MCU/BECN1/APP/MT-CO3/PIK3R4/APC2/WNT5B/APAF1/AGER/FZD1	7.17944862127102
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	69/1503	203/9376	2.12037009724394	COL1A2/COL4A1/COL4A2/COL1A1/THBS1/ACTN1/ACTB/LAMB3/COL6A2/COL6A3/VASP/CAPN2/ITGA1/COMP/FLNB/TNC/MYL9/EMP1/TLN1/CCND2/ACTN4/MYLK/PRKCG/LAMA4/COL6A1/CCND1/THBS2/JUN/IGF1/ITGA11/VCL/ACTG1/FLNA/PDGFA/ITGA5/AKT1/CRK/PARVA/PTK2/SRC/ITGB1/DOCK1/SHC1/GSK3B/VAV2/PIP5K1A/PIP5K1C/ROCK2/ITGAV/ZYX/PIK3R2/MYL10/PGF/MAP2K1/BCAR1/PIK3R1/THBS3/PDGFC/MAPK9/PIK3R3/EGFR/DIAPH1/ILK/TLN2/ITGA10/ELK1/ITGB3/LAMC3/LAMA2	7.05096946516727
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	57/1503	157/9376	2.2648206771171	FOS/UQCR11/NDUFA3/NDUFA4L2/NDUFB3/NDUFB2/NDUFB4/COX6C/COX7A2/UQCRQ/NDUFB7/NDUFS6/MAP3K5/COX8A/XBP1/COX7A1/NDUFA2/NDUFA13/JUN/NDUFA4/NDUFS8/NDUFB11/NDUFA7/NDUFA11/MLXIP/NDUFA6/AKT1/TGFB1/COX6B1/NDUFC1/COX6A1/UQCR10/NDUFB6/PPARA/COX7C/IL6/GSK3B/CXCL8/NDUFB1/EIF2AK3/PIK3R2/COX7B/NFKB1/CYCS/PIK3R1/MAPK9/PRKAG2/PIK3R3/GSK3A/PRKAA1/COX5B/NDUFV3/NDUFS1/CASP3/MT-CO2/MT-CO3/ADIPOR2	6.98283657894355
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	84/1503	275/9376	1.90548357829795	MT-ND3/NCAM2/ATP5F1E/EGR1/UQCR11/NDUFA3/NDUFA4L2/NDUFB3/CREB3L2/NDUFB2/NDUFB4/RYR2/CACNA1C/COX6C/COX7A2/MT-ND5/TUBB6/UQCRQ/NDUFB7/HSPA8/MT-ATP8/NDUFS6/PRKCD/COX8A/COX7A1/NDUFA2/NDUFA13/NDUFA4/TUBA1A/NDUFS8/TUBB2A/NDUFB11/NDUFA7/NDUFA11/NDUFA6/COX6B1/NDUFC1/ATP5MC1/COX6A1/PRKACA/ATP5MC3/UQCR10/NDUFB6/PSMD14/TUBA1B/PSMD2/PSMC4/COX7C/IL6/PSMD1/GSK3B/MT-ND6/TUBB4B/ATP5PB/ITPR2/NDUFB1/PPIF/EIF2AK3/PIK3R2/C9/COX7B/STIP1/HSPA5/SLC25A4/TUBA1C/CREB3/CYCS/PIK3R1/KLC2/MAPK9/SLC25A5/PIK3R3/PRKACB/ATP5F1D/COX5B/NDUFV3/VDAC1/NDUFS1/CASP3/MT-CO2/ITPR1/MCU/MT-CO3/APAF1	6.65882146653966
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	79/1503	253/9376	1.94789340949195	ACTN1/ACTB/CAPN2/WIPI1/MYL9/HK1/TLN1/ACTN4/SEPTIN6/PRKCD/ARPC1B/PFN1/JUN/ARPC2/CAPN1/VCL/CTTN/ACTG1/FOXO6/ITGA5/AKT1/CRK/HK2/SEPTIN8/CAPNS1/SEPTIN2/PTK2/SRC/ITGB1/DOCK1/MTOR/GSK3B/FOXO1/CXCL8/ITPR2/ROCK2/MAP1LC3C/PIK3R2/MYL10/MAP1LC3A/ARPC5L/NAIP/ELMO2/TNIP1/CD14/SEPTIN9/UBE2V1/TECPR1/TRAF5/BCAR1/NFKB1/CYCS/PIK3R1/CYTH3/UBE2N/SEPTIN11/PYCARD/MAPK9/BTRC/PIK3R3/GSK3A/RBX1/EGFR/VDAC1/UBA52/DIAPH1/ILK/ITPR1/BECN1/NOD1/TLN2/PIK3R4/NFKBIA/U2AF1L4/RPTOR/ACTR3B/RPS6KB2/AKT1S1/ARPC4	6.67799254121031
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	73/1503	227/9376	2.00611405676166	MT-ND3/ATP5F1E/FOS/UQCR11/NDUFA3/NDUFA4L2/NDUFB3/NDUFB2/NDUFB4/COX6C/COX7A2/MT-ND5/UQCRQ/NDUFB7/MT-ATP8/NDUFS6/MAP3K5/PRKCD/COX8A/COX7A1/NDUFA2/NDUFA13/JUN/NDUFA4/NDUFS8/NDUFB11/CBR1/NDUFA7/NDUFA11/HIF1A/NDUFA6/AKT1/COX6B1/NDUFC1/ATP5MC1/COX6A1/ATP5MC3/UQCR10/NDUFB6/PTK2/SRC/COX7C/MT-ND6/ATP5PB/NDUFB1/GSTM4/GSTO2/PPIF/PIK3R2/AHR/COX7B/MAP2K1/SLC25A4/MAP3K14/NFKB1/PIK3R1/PRKD2/AKR1A1/MAPK9/SLC25A5/PIK3R3/SLC26A6/KEAP1/ATP5F1D/COX5B/EGFR/NDUFV3/VDAC1/NDUFS1/MT-CO2/MT-CO3/NFKBIA/CYP1B1	6.7045299364672
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	91/1503	308/9376	1.843101675437	MT-ND3/ATP5F1E/GPX7/UQCR11/NDUFA3/HIP1/NDUFA4L2/POLR2L/NDUFB3/ACTR1A/CREB3L2/NDUFB2/WIPI1/NDUFB4/COX6C/COX7A2/MT-ND5/TUBB6/UQCRQ/NDUFB7/MT-ATP8/NDUFS6/GPX8/MAP3K5/COX8A/COX7A1/NDUFA2/NDUFA13/NDUFA4/TUBA1A/NDUFS8/TUBB2A/NDUFB11/NDUFA7/NDUFA11/NDUFA6/SLC1A2/COX6B1/NDUFC1/DCTN2/ATP5MC1/COX6A1/ATP5MC3/UQCR10/NDUFB6/PSMD14/TUBA1B/AP2S1/PSMD2/PSMC4/SIN3A/COX7C/ATG101/MTOR/IFT57/PSMD1/MT-ND6/TUBB4B/ATP5PB/NDUFB1/PPIF/COX7B/POLR2J/SLC25A4/TUBA1C/CREB3/DCTN5/CYCS/KLC2/MAPK9/TFAM/SLC25A5/AP2A2/ATP5F1D/COX5B/NRBF2/CLTCL1/NDUFV3/VDAC1/NDUFS1/CASP3/MT-CO2/ITPR1/BECN1/DNAH17/MT-CO3/DNAH3/PIK3R4/RCOR1/DCTN1/APAF1	6.57346806864827
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	51/1503	138/9376	2.30541814920883	MT-ND3/ATP5F1E/UQCR11/NDUFA3/NDUFA4L2/NDUFB3/ATP5MF/NDUFB2/NDUFB4/COX6C/COX7A2/MT-ND5/UQCRQ/NDUFB7/MT-ATP8/NDUFS6/COX8A/COX7A1/NDUFA2/NDUFA13/NDUFA4/NDUFS8/NDUFB11/NDUFA7/NDUFA11/NDUFA6/COX6B1/NDUFC1/ATP5MC1/COX6A1/ATP5MC3/UQCR10/NDUFB6/COX17/ATP5ME/ATP6V0D1/COX7C/PPA1/MT-ND6/ATP5PB/NDUFB1/COX7B/CYCS/ATP6V1E2/ATP5F1D/COX5B/NDUFV3/NDUFS1/MT-CO2/MT-CO3/ATP5MGL	6.74986696693111
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	102/1503	368/9376	1.72906361190662	MT-ND3/ATP5F1E/GPX7/ACTB/UQCR11/NDUFA3/NDUFA4L2/NDUFB3/ACTR1A/NDUFB2/WIPI1/NDUFB4/COX6C/COX7A2/MT-ND5/TUBB6/UQCRQ/NDUFB7/MT-ATP8/NDUFS6/GPX8/MAP3K5/COX8A/XBP1/COX7A1/NDUFA2/CHCHD10/NDUFA13/PFN1/NDUFA4/ACTG1/ANXA11/SEC13/TUBA1A/NDUFS8/TUBB2A/NDUFB11/NDUFA7/NDUFA11/NDUFA6/SLC1A2/COX6B1/NDUFC1/DCTN2/POM121C/ATP5MC1/COX6A1/ATP5MC3/UQCR10/PINK1/NDUFB6/PSMD14/TUBA1B/MAP2K3/NUP153/PSMD2/NUP188/PSMC4/COX7C/ATG101/MTOR/PSMD1/MT-ND6/TUBB4B/ATP5PB/NDUFB1/MAP1LC3C/EIF2AK3/VCP/MAP1LC3A/NXF1/COX7B/HSPA5/TOMM40/TUBA1C/DCTN5/CYCS/KLC2/SETX/ATP5F1D/ATF6/ALYREF/CHMP2B/RAB8A/COX5B/NRBF2/NDUFV3/VDAC1/NDUFS1/CASP3/MT-CO2/MCU/BECN1/DNAH17/MT-CO3/UBQLN4/FUS/DNAH3/PIK3R4/NUP98/DCTN1/APAF1	6.23404806185646
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	125/1503	480/9376	1.6245287203371	MT-ND3/ATP5F1E/GPX7/UQCR11/NDUFA3/HIP1/NDUFA4L2/NDUFB3/CALM1/ACTR1A/NDUFB2/CAPN2/WIPI1/NDUFB4/RYR2/CACNA1C/COX6C/COX7A2/MT-ND5/TUBB6/UQCRQ/NDUFB7/MT-ATP8/PTGS2/NDUFS6/WNT2B/GPX8/MAP3K5/PRKCG/COX8A/XBP1/COX7A1/NDUFA2/NDUFA13/WNT11/NDUFA4/CAPN1/TUBA1A/NDUFS8/TUBB2A/NDUFB11/NDUFA7/NDUFA11/ATP2A2/NDUFA6/COX6B1/NDUFC1/DCTN2/ATP5MC1/COX6A1/ATP5MC3/UQCR10/PINK1/LRP5/NDUFB6/PSMD14/TUBA1B/MAP2K3/ATP2A3/PSMD2/PSMC4/COX7C/ATG101/MTOR/UBE2J1/IL6/IFT57/CAMK2G/PSMD1/GSK3B/MT-ND6/TUBB4B/ATP5PB/BAK1/ITPR2/NDUFB1/MAP1LC3C/PPIF/EIF2AK3/VCP/MAP1LC3A/COX7B/MAP2K1/HSPA5/SLC25A4/TOMM40/TUBA1C/NFKB1/DCTN5/CYCS/KLC2/MAPK9/SLC25A5/GPR37/FADD/PSEN2/LRP6/ATP5F1D/ATF6/CHMP2B/RAB8A/COX5B/NRBF2/NDUFV3/VDAC1/NDUFS1/CASP3/UBA52/MT-CO2/ITPR1/MCU/BECN1/APP/DNAH17/UBE2G1/MT-CO3/FUS/DNAH3/PIK3R4/APC2/DCTN1/WNT5B/APAF1/AGER/FZD1	6.13720527294508
NA	NA	hsa04518	Integrin signaling	53/1503	154/9376	2.14690964391563	COL1A2/COL4A1/COL4A2/COL1A1/THBS1/ACTN1/ACTB/LAMB3/COL6A2/COL6A3/ITGA1/COMP/FERMT2/FLNB/TNC/TLN1/CCND2/ACTN4/LAMA4/COL6A1/CCND1/THBS2/IGF1/ITGA11/VCL/ACTG1/FLNA/PDGFA/ITGA5/AKT1/TGFB1/PARVA/PTK2/SRC/ITGB1/MTOR/GSK3B/ITGAV/LIMS1/PIK3R2/PGF/PIK3R1/THBS3/PDGFC/PIK3R3/EGFR/FBN1/ILK/TLN2/ITGA10/ITGB3/LAMC3/LAMA2	6.27006450556311
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	32/1503	78/9376	2.55925755326953	ACTB/SEPTIN6/ARPC1B/ARPC2/VCL/CTTN/ACTG1/ITGA5/CRK/SEPTIN8/DNM1/SEPTIN2/PTK2/SRC/ITGB1/DOCK1/ARHGAP10/SHC1/DNM2/PIK3R2/CTNNA1/ARPC5L/ELMO2/SEPTIN9/BCAR1/PIK3R1/SEPTIN11/PIK3R3/CLTCL1/ILK/ACTR3B/ARPC4	6.0417867123394
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	51/1503	157/9376	2.02641850057846	SERPINE1/TGFB3/ZFP36L2/CALM1/CAPN2/CCND2/HLA-B/CCND1/MAPKAPK2/E2F4/CAPN1/MYC/CHEK2/NFATC1/NFATC2/AKT1/TGFB1/TGFBR2/HIPK4/HLA-F/MAP2K3/GADD45B/MTOR/TGFB2/IL6/FOXO1/TGFBR1/CXCL8/RAD1/CDK2/ITPR2/PIK3R2/NFATC4/MAP2K1/TSC2/MRAS/SLC25A4/NFKB1/PIK3R1/ATR/SLC25A5/BTRC/PIK3R3/RB1/VDAC1/ITPR1/MCU/CDK6/LIN52/HIPK2/TRAF3IP2	5.66666309368066
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	14/1503	21/9376	4.15879352406298	CSGALNACT1/XYLT1/CHST3/CHSY1/CHSY3/CHPF/B3GALT6/DSE/XYLT2/CHPF2/CHST12/DSEL/B4GALT7/CHST14	6.33146183266901
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	38/1503	105/9376	2.25763077020562	CACNA2D1/LMNA/ACTB/SSPN/TPM4/TGFB3/ITGA1/RYR2/CACNA1C/SGCD/SLC8A1/TPM2/IGF1/ITGA11/ACTG1/TPM1/ATP2A2/ITGA5/TGFB1/PRKACA/ADCY7/ATP2A3/ADCY6/ITGB1/TNNI3/TGFB2/CACNG7/ITGAV/ADCY5/SNTB2/SNTB1/DAG1/PRKACB/SGCB/ITGA10/CACNB3/ITGB3/LAMA2	5.66212582850707
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	36/1503	99/9376	2.26843283130708	CACNA2D1/LMNA/ACTB/SSPN/TPM4/TGFB3/ITGA1/RYR2/CACNA1C/SGCD/SLC8A1/TPM2/IGF1/ITGA11/ACTG1/TPM1/ATP2A2/ITGA5/TGFB1/ATP2A3/ITGB1/TNNI3/TGFB2/IL6/CACNG7/ITGAV/SNTB2/SNTB1/PRKAG2/DAG1/PRKAA1/SGCB/ITGA10/CACNB3/ITGB3/LAMA2	5.54340100558048
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	60/1503	204/9376	1.83476184885132	COL1A2/TIMP3/GPC3/COL1A1/THBS1/ACTB/PLAU/SDC2/EZR/MSN/WNT2B/PRKCG/SLC9A1/ARHGEF1/CCND1/WNT11/IGF1/CTTN/MYC/STAT3/ACTG1/FLNA/HIF1A/FGFR1/FRS2/ITGA5/AKT1/TGFB1/HSPG2/PRKACA/DDX5/PTK2/IQGAP1/SRC/ITGB1/MTOR/ANK2/TGFB2/CAMK2G/VAV2/ITPR2/ROCK2/ITGAV/PIK3R2/MAP2K1/MRAS/PIK3R1/PIK3R3/RDX/PRKACB/HSPB2/EGFR/PLAUR/CASP3/ITPR1/ELK1/RPS6KB2/WNT5B/ITGB3/FZD1	5.2667251612448
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	53/1503	174/9376	1.90013842047705	PPP1R15A/ERLEC1/SEC24D/CKAP4/CAPN2/RRBP1/SSR4/HSPA8/P4HB/MAP3K5/XBP1/SEC24A/SEC61B/CAPN1/SEC13/SEC62/TMEM258/SEC61G/ERO1B/SEC23A/HSP90B1/DNAJC1/RPN2/UBE2J1/DNAJC10/SELENOS/BAK1/CALR/SEC23B/EIF2AK3/VCP/DNAJB12/KRTCAP2/EDEM2/MOGS/HSPA5/SAR1B/DNAJC5/DNAJB1/SEC31A/MAPK9/STT3A/ERO1A/DNAJB11/ATF6/MAN1A2/RBX1/MAN1C1/UBE2G1/UBQLN4/OSTC/BAG2/UBE4B	5.23646025390201
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	65/1503	232/9376	1.74776883015578	CFL1/ACTN1/ACTB/TMSB4X/ENAH/GSN/LIMK1/ITGA1/MYL9/EZR/MSN/ACTN4/MYLK/ARPC1B/SLC9A1/F2R/ARHGEF1/PFN1/ARPC2/ITGA11/VCL/ACTG1/SSH2/PDGFA/MYH10/FGFR1/ITGA5/AKT1/CRK/MYH9/PTK2/FGFR2/IQGAP1/SRC/ITGB1/DOCK1/VAV2/PIP5K1A/PIP5K1C/ROCK2/ITGAV/CYFIP1/PIK3R2/MYL10/C9/SPATA13/ARPC5L/MAP2K1/BCAR1/MRAS/PIK3R1/SSH1/PDGFC/PIK3R3/RDX/GNA12/EGFR/DIAPH1/FGF1/ABI2/APC2/ITGA10/ACTR3B/ITGB3/ARPC4	5.03892906515298
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	51/1503	170/9376	1.87145708582834	ACTN1/ACTB/VASP/CLDN1/CGNL1/MYL9/EZR/MSN/ACTN4/MAP3K5/ARPC1B/RUNX1/LLGL1/CCND1/JUN/ARPC2/CTTN/ACTG1/TUBA1A/MYH10/RAB13/MYH9/PRKACA/TUBA1B/SRC/ITGB1/PCNA/ROCK2/PPP2R2D/F11R/PARD6G/ARPC5L/CFTR/AFDN/MYL6/TUBA1C/PPP2CA/SYNPO/DLG1/MAPK9/PRKAG2/RDX/PRKACB/RAPGEF2/PRKAA1/RAB8A/CLDN16/ARHGAP17/ACTR3B/WHAMM/ARPC4	5.00991068739734
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	43/1503	137/9376	1.9579721335917	LMNA/FOS/ACTB/CAPN2/MAP3K5/JUN/SEPTIN4/CAPN1/ACTG1/TUBA1A/AKT1/TNFRSF10B/TUBA1B/CTSC/PARP1/GADD45B/CTSF/CTSZ/DAB2IP/BAK1/ITPR2/CTSS/EIF2AK3/CASP6/PIK3R2/LMNB2/MAP2K1/TUBA1C/MAP3K14/NFKB1/CYCS/PIK3R1/MAPK9/PIK3R3/FADD/AIFM1/IL3RA/DFFA/NOL3/CASP3/ITPR1/NFKBIA/APAF1	4.93509683726503
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	62/1503	224/9376	1.72664195418686	EGR1/FOS/TGFB3/NRP1/MSX1/CD40/CREB3L2/ANAPC11/TLN1/CCND2/EGR2/HLA-B/CCND1/JUN/MYC/CHEK2/NFATC1/NFATC2/AKT1/TGFB1/MAD1L1/TGFBR2/SRF/PRKACA/ZFP36/HLA-F/ADCY7/ADCY6/HLA-DRA/TGFB2/IL6/TGFBR1/CDK2/CALR/HLA-DPB1/STAT5A/PIK3R2/NFATC4/TRRAP/MAP2K1/ADCY5/CD4/SLC25A4/MAP3K14/NFKB1/CREB3/DLG1/PIK3R1/ATR/MAPK9/SLC25A5/PIK3R3/PRKACB/RB1/VDAC1/TSPO/CDC27/KAT2A/TLN2/NFKBIA/RELB/ELK1	4.80929564275003
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	31/1503	87/9376	2.22280343527504	CACNA2D1/UQCR11/ATP1B1/TPM4/RYR2/CACNA1C/COX6C/COX7A2/UQCRQ/COX8A/COX7A1/SLC9A1/SLC8A1/TPM2/TPM1/ATP2A2/COX6B1/COX6A1/UQCR10/ATP2A3/COX7C/ASPH/TNNI3/CACNG7/COX7B/COX5B/ATP1B3/MT-CO2/MT-CO3/CACNB3/HRC	5.00641443240429
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	43/1503	138/9376	1.94378392972509	FOS/ACTB/LIMK1/ARPC1B/IRAK1/ARHGEF1/JUN/ARPC2/GIT2/ACTG1/NFATC1/NFATC2/ITGA5/AKT1/CRK/CCL2/PTK2/MAP2K3/SRC/ITGB1/DOCK1/IL6/GSK3B/VAV2/CXCL8/PIP5K1A/PIP5K1C/ROCK2/PIK3R2/ARPC5L/ELMO2/RPS6KA3/MAP2K1/CD4/BCAR1/NFKB1/PIK3R1/PYCARD/MAPK9/PIK3R3/NFKBIA/ACTR3B/ARPC4	4.87998115778666
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	62/1503	227/9376	1.7038228975236	CALM1/CREB3L2/PTGS2/PRKCG/HLA-B/ARHGEF1/CCND1/GNG5/MYC/STAT3/NFATC1/NFATC2/CCL4/ARHGEF11/GNAI2/AKT1/CRK/PRKACA/CCL2/PTK2/HLA-F/CCL3/ADCY7/SRC/ADCY6/MTOR/IL6/GSK3B/CXCL8/BAK1/ITPR2/CALR/ROCK2/ITGAV/PIK3R2/GNB4/NFATC4/MAP2K1/ADCY5/TSC2/TRAF5/BCAR1/AKAP13/NFKB1/CREB3/CYCS/PIK3R1/GNB5/PIK3R3/FADD/PRKACB/GNA12/RB1/EGFR/CASP3/ITPR1/CDK6/NFKBIA/ELK1/RPS6KB2/ITGB3/GNG11	4.69012598989651
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	38/1503	122/9376	1.94304287599664	ACTB/ATP1B1/NOTCH3/RCAN1/SLCO1C1/PRKCG/SLC9A1/CCND1/PFKL/MYC/ACTG1/HIF1A/ATP2A2/AKT1/PRKACA/MED27/SRC/ATP2A3/PFKP/SIN3A/MTOR/GSK3B/FOXO1/MED24/ITGAV/PIK3R2/HDAC3/MAP2K1/TSC2/SLC16A2/PIK3R1/PIK3R3/PRKACB/NCOR1/ATP1B3/KAT2A/MED14/ITGB3	4.58080293741857
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	65/1503	248/9376	1.63500955079089	FOS/ACTB/ACTR1A/TUBB6/MYL9/RHOB/ARPC1B/IRAK1/PFN1/JUN/ARPC2/MYC/GSDMD/ACTG1/FLNA/TUBA1A/TUBB2A/ANXA2/AKT1/TNFRSF10B/RAB5C/KPNA3/DCTN2/TUBA1B/HSP90B1/MAP2K3/IL6/DYNLT3/S100A10/CXCL8/FHOD1/TUBB4B/BAK1/DNM2/ROCK2/CYFIP1/DYNLL2/MYL10/ARPC5L/NAIP/ELMO2/CD14/MAP2K1/TUBA1C/NFKB1/TCF7/DCTN5/CYCS/CYTH3/KLC2/PYCARD/GAPDH/MAPK9/FADD/PIK3C2A/VPS39/CASP3/DYNC1LI2/ACBD3/NOD1/NFKBIA/ACTR3B/DCTN1/ARPC4/MYO6	4.42805783706161
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	33/1503	101/9376	2.03822058852592	COL1A2/COL4A1/EGR1/COL4A2/SERPINE1/COL1A1/TGFB3/COL3A1/THBD/PRKCD/CCND1/JUN/STAT3/NFATC1/AKT1/TGFB1/TGFBR2/CCL2/TGFB2/IL6/FOXO1/TGFBR1/CXCL8/STAT5A/PIK3R2/NFKB1/PIK3R1/MAPK9/PIK3R3/F3/CASP3/DIAPH1/AGER	4.58340640663466
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	81/1503	333/9376	1.51739763715812	COL1A2/COL4A1/COL4A2/COL1A1/THBS1/LAMB3/COL6A2/HEYL/NOTCH3/COL6A3/CREB3L2/ITGA1/COMP/TNC/CCND2/PTGS2/WNT2B/PKM/LAMA4/LLGL1/COL6A1/HLA-B/CCND1/THBS2/WNT11/ITGA11/IRF1/ITGA5/AKT1/TUBG1/PRKACA/PTK2/HLA-F/ISG15/STAT2/ITGB1/ATP6V0D1/MTOR/GSK3B/FOXO1/HES4/CDK2/JAG1/BAK1/ITGAV/PPP2R2D/TRAF3/PIK3R2/HES1/PARD6G/MAP2K1/TSC2/IFNAR2/NFKB1/PPP2CA/TCF7/CREB3/DLG1/PIK3R1/ATR/PPP2R5C/THBS3/PIK3R3/ATP6V1E2/FADD/PRKACB/CHD4/IKBKE/PPP2R5B/RB1/EGFR/CASP3/CDK6/APC2/ITGA10/RPS6KB2/WNT5B/ITGB3/LAMC3/LAMA2/FZD1	4.2003482113728
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	46/1503	163/9376	1.76047087828433	FOS/TGFB3/YWHAB/CREB3L2/EGR2/PRKCG/IRAK1/JUN/MYC/STAT3/NFATC1/NFATC2/AKT1/TGFB1/TGFBR2/HSPG2/YWHAZ/MAP2K3/STAT2/SRC/TGFB2/IL6/TGFBR1/CXCL8/EGR3/CDK2/PCNA/STAT5A/TRAF3/PIK3R2/NFATC4/MAP2K1/NFKB1/STAT6/CREB3/CYCS/PIK3R1/MAPK9/PIK3R3/FADD/IKBKE/RB1/CASP3/NFKBIA/ELK1/APAF1	4.27928150861286
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	53/1503	196/9376	1.68685757736228	FOS/CALM1/RCAN1/PTGS2/LYN/HLA-B/CCND1/MAPKAPK2/JUN/GNG5/MYC/STAT3/NFATC1/NFATC2/HIF1A/MICB/AKT1/ZFP36/HLA-F/STAT2/SRC/CXCL2/MTOR/IL6/GSK3B/CXCL8/BAK1/ITPR2/MAP1LC3C/TRAF3/PIK3R2/MAP1LC3A/GNB4/NFATC4/MAP2K1/IFNAR2/NFKB1/TCF7/CYCS/PIK3R1/MAPK9/GNB5/PIK3R3/FADD/IKBKE/RB1/CASP3/UBA52/ITPR1/BECN1/CDK6/NFKBIA/GNG11	4.24588660786732
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	41/1503	140/9376	1.82689858378481	ACTA2/EGR1/SERPINE1/NOTCH3/CALM1/RYR2/MYLK/SLC9A1/CCND1/SLC8A1/GNG5/GNAI2/AKT1/PRKACA/ADCY7/ADCY6/KLF2/MTOR/TGFBR1/PDE3B/JAG1/ITPR2/MAP1LC3C/MAP1LC3A/GNB4/MAP2K1/ADCY5/MRAS/PLAT/TFAM/PRKAG2/GNB5/PRKACB/HDAC4/PRKAA1/ITPR1/BECN1/PIK3R4/RPS6KB2/GNG11/APLNR	4.30694480943677
NA	NA	hsa04517	IgSF CAM signaling	74/1503	299/9376	1.54389993702673	NCAM2/ACTN1/ACTB/LRRTM4/NRP1/NECTIN2/TUBB6/MYL9/EZR/MSN/ACTN4/LYN/MYLK/PLXNA4/PRKCG/UNC5C/ARPC1B/ERC1/ARPC2/VCL/NECTIN4/ACTG1/SORBS1/CNTNAP2/ROBO2/TUBA1A/MYH10/TUBB2A/NRP2/FGFR1/ITGA5/AKT1/PTPRS/MYH9/CLMP/CASK/PTK2/TUBA1B/IQGAP1/PTPRD/SRC/ITGB1/ANK2/UNC5B/GSK3B/VAV2/FOXO1/PLXNA2/TUBB4B/IL1RAP/EPB41L2/GRIP2/DYNLL2/EPB41L1/F11R/PIK3R2/PARD6G/ARPC5L/SPTBN1/AFDN/MAP2K1/BCAR1/MYL6/TUBA1C/PIK3R1/MAPK9/PIK3R3/RDX/RAPGEF2/APP/ACTR3B/ITGB3/MTSS1/ARPC4	4.17617258186514
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	44/1503	154/9376	1.78234008174128	CACNA2D1/GUCY1A1/FOS/ACTB/CALM1/RCAN1/GUCY1A2/RYR2/CACNA1C/MYL9/GUCY1B1/PTGS2/MYLK/PRKCG/CCND1/JUN/ACTG1/NFATC1/NFATC2/GNAI2/CAMK1D/PRKACA/MAP2K5/ADCY7/SRC/ADCY6/CAMK2G/CACNG7/ITPR2/ROCK2/NFATC4/MAP2K1/ADCY5/CAMKK2/MYL6/PRKAG2/PRKACB/KCNJ14/PRKAA1/EGFR/ITPR1/ELK1/CACNB3/EEF2K	4.27699148213473
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	25/1503	71/9376	2.19654587538538	IDH2/PGAM1/HK1/PKM/LDHA/TIGAR/PFKL/MYC/HIF1A/FGFR1/AKT1/HK2/FGFR2/PFKP/MTOR/PIK3R2/SCO2/MAP2K1/PIK3R1/G6PD/SLC7A5/PIK3R3/EGFR/SIRT6/IDH1	4.42176178973311
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	30/1503	93/9376	2.01231944712725	COL4A1/COL4A2/LAMB3/PTGS2/LAMA4/CCND1/MYC/AKT1/PTK2/BIRC7/ITGB1/GADD45B/CDK2/SKP2/BAK1/ITGAV/TRAF3/PIK3R2/TRAF5/NFKB1/CYCS/PIK3R1/PIK3R3/RB1/CASP3/CDK6/NFKBIA/APAF1/LAMC3/LAMA2	4.28656962067923
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	53/1503	200/9376	1.65312042581504	FOS/ACTB/CLDN1/SEC24D/TUBB6/EZR/ARPC1B/SEC24A/IRAK1/F2R/ARHGEF1/JUN/MYO1D/ARPC2/CTTN/ACTG1/TUBA1A/MYH10/TUBB2A/ARHGEF11/MYO1B/ABCF2/MYO5A/TNFRSF10B/MYH9/TUBA1B/SRC/ITGB1/MYO1C/IL6/CXCL8/TUBB4B/BAK1/ROCK2/CYFIP1/ARPC5L/NAIP/TUBA1C/NFKB1/MYO10/CYCS/CYTH3/PYCARD/GAPDH/MAPK9/FADD/GNA12/CASP3/CLDN16/NFKBIA/ACTR3B/ARPC4/MYO6	4.07921470319245
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	13/1503	27/9376	3.00357310071216	ELOVL5/SCD5/ACOT7/FADS2/ELOVL1/HSD17B4/HSD17B12/ACOT2/ACOX1/ACOX3/ELOVL3/SCP2/ELOVL6	4.55511658936483
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	32/1503	103/9376	1.93807853548566	COL1A2/COL4A1/COL4A2/COL1A1/ACTN1/LAMB3/TGFB3/COL3A1/ACTN4/PRKCG/LAMA4/ARG2/VCL/TGFB1/RAB5C/PRKACA/PTK2/CXCL2/TGFB2/IL6/CXCL8/PIK3R2/C9/CD14/HSPB1/NFKB1/PIK3R1/PIK3R3/PRKACB/CASP3/LAMC3/LAMA2	4.18256485681217
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	73/1503	300/9376	1.51795963628299	CACNA2D1/DUSP1/NR4A1/FOS/TGFB3/CACNA1C/HSPA8/MAP3K5/PRKCG/DUSP10/IRAK1/DUSP6/MAP4K4/MAPKAPK2/JUN/IGF1/CACNA1G/MYC/TEK/FLNA/PDGFA/NFATC1/FGFR1/AKT1/CRK/TGFB1/MAP3K13/TGFBR2/SRF/PRKACA/ANGPT1/RPS6KA4/MKNK1/MAP2K5/FGFR2/MAP2K3/GADD45B/NF1/TGFB2/DUSP7/TGFBR1/CACNG7/EFNA5/IL1RAP/MAPK8IP1/JUND/EPHA2/PGF/RPS6KA3/CD14/TAOK3/MAP2K1/MRAS/HSPB1/MAP3K14/NFKB1/PDGFC/MAPK9/PRKACB/GNA12/RAPGEF2/RASGRP2/PPP5C/EGFR/NLK/MAP4K2/CASP3/DUSP5/FGF1/RELB/ELK1/CACNB3/MAPK8IP3	3.98386216143098
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	28/1503	86/9376	2.0310386977982	CACNA2D1/LMNA/ACTB/SSPN/ITGA1/RYR2/CACNA1C/DSP/SGCD/SLC8A1/ITGA11/ACTG1/ATP2A2/ITGA5/ATP2A3/ITGB1/CACNG7/ITGAV/CTNNA1/TCF7/SNTB2/SNTB1/DAG1/SGCB/ITGA10/CACNB3/ITGB3/LAMA2	4.19673297496665
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	55/1503	212/9376	1.61839842327923	THBS1/ACTB/ENAH/VASP/DOCK4/CALM1/TLN1/PRKCG/ID1/F2R/PFN1/IGF1/RAP1GAP/ACTG1/TEK/PDGFA/MAGI3/SIPA1L1/FGFR1/GNAI2/AKT1/CRK/SIPA1L3/FARP2/ANGPT1/FGFR2/MAP2K3/ADCY7/SRC/ADCY6/ITGB1/VAV2/SIPA1L2/SIPA1/EFNA5/PIK3R2/EPHA2/PARD6G/PGF/AFDN/MAP2K1/ADCY5/BCAR1/MRAS/PIK3R1/PRKD2/PDGFC/PIK3R3/RAPGEF2/RASGRP2/EGFR/ARAP3/FGF1/TLN2/ITGB3	3.97913585102157
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	32/1503	105/9376	1.90116275385736	CALM1/EGR2/PTGS2/PRKCD/MAPKAPK2/JUN/KSR1/IRF1/NFATC1/NFATC2/AKT1/PLK3/STAT2/SRC/IL6/EGR3/FCER1G/ITPR2/PIK3R2/NFATC4/MRAS/MAP3K14/NFKB1/PIK3R1/PYCARD/MAPK9/PIK3R3/IKBKE/ITPR1/NFKBIA/RELB/BCL3	4.05722969347362
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	34/1503	116/9376	1.82843508385528	IDH2/PGP/PGAM1/HK1/PKM/PFKL/GOT1/DLST/CPS1/PHGDH/PC/HK2/PGLS/OGDH/PFKP/FH/PGD/GPI/IDNK/GOT2/SDSL/ME2/TKTL1/GAPDH/G6PD/ENO4/ACOX1/TKFC/ACO2/PRPS2/ENO1/ACOX3/AGXT2/IDH1	3.92262676077517
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	41/1503	149/9376	1.71654900489848	MT-ND3/NDUFA3/NDUFA4L2/NDUFB3/NDUFB2/NDUFB4/CACNA1C/MT-ND5/NDUFB7/PTGS2/NDUFS6/PRKCG/NDUFA2/NDUFA13/NDUFA4/GNG5/MGLL/NDUFS8/NDUFB11/NDUFA7/NDUFA11/GNAI2/NDUFA6/NDUFC1/PRKACA/NDUFB6/ADCY7/ADCY6/MT-ND6/ITPR2/NDUFB1/GNB4/ADCY5/MAPK9/GNB5/PRKACB/NDUFV3/NDUFS1/DAGLB/ITPR1/GNG11	3.85215517991445
Organismal Systems	Immune system	hsa04611	Platelet activation	36/1503	126/9376	1.78234008174128	COL1A2/P2RX1/COL1A1/GUCY1A1/ACTB/VASP/COL3A1/GUCY1A2/TLN1/GUCY1B1/LYN/MYLK/F2R/ARHGEF1/ACTG1/GNAI2/AKT1/PTGIR/PRKACA/ADCY7/SRC/ADCY6/ITGB1/FCER1G/ITPR2/ROCK2/PIK3R2/ADCY5/PIK3R1/PIK3R3/PRKACB/RASGRP2/ITPR1/TLN2/ITGB3/BTK	3.86282461376197
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	20/1503	56/9376	2.2279251021766	CCND2/CCND1/GPR161/GLI3/GAS1/PRKACA/CSNK1G2/GSK3B/PTCH2/IQCE/MGRN1/CSNK1G3/SUFU/KIF7/BTRC/PRKACB/CSNK1G1/GLI2/EVC/EVC2	4.02673396307595
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	15/1503	37/9376	2.52899606193019	HK1/PMM2/PGM3/UXS1/GMPPB/GFPT1/HK2/GPI/UGP2/GMPPA/GFPT2/GMDS/GALK1/NAGK/PGM1	4.07147754534916
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	61/1503	250/9376	1.52211842980705	RAB31/TFRC/EHD4/HSPA8/GBF1/ARPC1B/SMAP1/HLA-B/ARF4/ARPC2/GIT2/ARFGAP1/DAB2/CHMP1A/TGFBR2/RAB5C/SH3KBP1/EHD1/EHD2/GRK5/RAB11B/DNM1/HLA-F/FGFR2/AP2S1/SRC/VPS45/EPN2/TGFBR1/ARF5/SH3GL1/PIP5K1A/VPS36/DNM2/PIP5K1C/RAB35/GRK4/SNX32/PARD6G/ARPC5L/LDLR/CYTH3/ACAP3/AP2A2/ARF3/LDLRAP1/AGAP1/CHMP2B/RAB8A/EGFR/EEA1/CLTCL1/ARAP3/PSD/EPN1/RAB11FIP3/ACTR3B/SNX4/IQSEC2/GRK6/ARPC4	3.65589570857397
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/1503	14/9376	3.56468016348256	CHST2/B4GALT1/B4GALT2/B3GNT2/ST3GAL2/ST3GAL3/CHST1/B4GALT4	4.19573368957218
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	34/1503	122/9376	1.73851204694436	SCD5/CREB3L2/RAB2A/CCND1/IGF1/PFKL/AKT1/RAB11B/PFKP/MTOR/FOXO1/PFKFB4/PPP2R2D/PIK3R2/CFTR/TSC2/CAMKK2/PPP2CA/CREB3/PIK3R1/PPP2R5C/PRKAG2/PIK3R3/PPP2R5B/PRKAA1/RAB8A/GYS1/ACACA/CPT1A/ADIPOR2/RPTOR/RPS6KB2/AKT1S1/EEF2K	3.58730047176963
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	24/1503	77/9376	1.94437099826321	TGFB3/RUNX1/CCND1/MYC/AKT1/CRK/TGFB1/TGFBR2/GADD45B/CTBP2/TGFB2/SHC1/TGFBR1/BAK1/STAT5A/PIK3R2/MAP2K1/NFKB1/PIK3R1/PIK3R3/RB1/CDK6/NFKBIA/CTBP1	3.6355061435442
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	31/1503	109/9376	1.77416420980669	CREB3L2/SLC27A4/PRKCD/PYGB/STAT3/PPP1R3C/MLXIP/PTPA/AKT1/GFPT1/PPARA/MTOR/IL6/GSK3B/FOXO1/PYGM/PIK3R2/RPS6KA3/NFKB1/CREB3/TRIB3/PIK3R1/GFPT2/MAPK9/PRKAG2/PIK3R3/PRKAA1/GYS1/CPT1A/NFKBIA/RPS6KB2	3.55199020847524
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	53/1503	216/9376	1.53066706093985	FOS/CALM1/CD40/HSPA8/LYN/MAP3K5/XBP1/IRAK1/ARHGEF1/JUN/STAT3/NFATC1/NFATC2/AKT1/TNFRSF10B/CCL2/PTK2/CCL3/HSP90B1/MAP2K3/SRC/CXCL2/IL6/CAMK2G/GSK3B/VAV2/CXCL8/ROCK2/EIF2AK3/TRAF3/CASP6/PIK3R2/CD14/ABCG1/HSPA5/HSPA2/NFKB1/CYCS/PIK3R1/LDLR/PYCARD/MAPK9/ERO1A/PIK3R3/OLR1/IKBKE/ATF6/ABCA1/CASP3/ITPR1/NFKBIA/APAF1/AGER	3.44743647956044
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	41/1503	157/9376	1.62908153968072	SERPINE1/ACTB/TGFB3/YWHAB/BMP7/CCND2/WNT2B/ID1/LLGL1/LATS2/CCND1/NKD2/WNT11/MYC/ACTG1/SMAD7/TGFB1/TGFBR2/WWC1/YWHAZ/TEAD4/TP53BP2/SNAI2/TGFB2/GSK3B/TGFBR1/PPP2R2D/YWHAH/CTNNA1/PARD6G/PPP2CA/TCF7/DLG1/BMPR2/BTRC/TEAD3/GLI2/FGF1/APC2/WNT5B/FZD1	3.4730406182425
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	33/1503	119/9376	1.72991831463124	JUNB/FOS/CREB3L2/PTGS2/MAP3K5/ADAM17/JUN/IRF1/AKT1/RHBDF2/RPS6KA4/CCL2/MAP2K3/CXCL2/IL6/RHBDF1/DAB2IP/JAG1/TRAF3/PIK3R2/MAP2K1/TRAF5/MAP3K14/NFKB1/CREB3/PIK3R1/DNM1L/MAPK9/PIK3R3/FADD/CASP3/NFKBIA/BCL3	3.5011249665288
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	37/1503	138/9376	1.67255826511229	CALM1/HK1/PYGB/PPP1R3C/SORBS1/AKT1/CRK/PRKACA/HK2/MKNK1/MTOR/SHC1/GSK3B/FOXO1/PDE3B/PYGM/PPP1R3F/PIK3R2/MAP2K1/TSC2/PIK3R1/SOCS4/PHKA2/MAPK9/PRKAG2/PIK3R3/PRKACB/INPP5A/PRKAA1/GYS1/PHKG2/ACACA/PRKAR1B/PHKG1/RPTOR/ELK1/RPS6KB2	3.47756680092833
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	26/1503	87/9376	1.86428675216617	FOS/TGFB3/CCND1/JUN/MYC/AKT1/TGFB1/TGFBR2/GADD45B/MTOR/TGFB2/GSK3B/TGFBR1/BAK1/MSH3/PIK3R2/MAP2K1/TCF7/CYCS/PIK3R1/MAPK9/PIK3R3/EGFR/CASP3/APC2/RPS6KB2	3.53857173193765
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	31/1503	110/9376	1.75803544426299	THBS1/TGFB3/TFRC/LTBP1/BMP7/ID1/LRRC32/E2F4/MYC/FMOD/FST/SMAD7/TGFB1/TGFBR2/EMP3/SIN3A/TGFB2/TFDP1/TGFBR1/SKI/INHBA/PPP2CA/ID4/BMPR2/RBX1/NCOR1/SKIL/FBN1/LEFTY1/RPS6KB2/ID3	3.49409501261366
Cellular Processes	Cell motility	hsa04814	Motor proteins	48/1503	194/9376	1.54346976150791	KIF26B/ACTA2/ACTB/TPM4/ACTR1A/ACTG2/TUBB6/MYL9/TPM2/MYO1D/ACTG1/TPM1/KIFAP3/TUBA1A/MYH10/TUBB2A/MYO1B/MYO9B/TUBG1/MYO5A/DCTN2/MYH9/TUBA1B/TNNI3/MYO1C/DYNLT3/TUBB4B/MYH13/TNNC2/KIF2A/DYNLL2/MYL10/KIF21B/MYL6/TUBA1C/MYO10/DCTN5/KLC2/KIF7/DYNC1LI2/KIF13A/KIFC3/DNAH17/DNAH3/DCTN1/TNNT1/MYO15B/MYO6	3.34197047385725
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/1503	93/9376	1.81108750241453	ACTN1/ACTB/NECTIN2/MYL9/ACTN4/VCL/NECTIN4/ACTG1/SORBS1/FGFR1/TGFBR2/FARP2/IQGAP1/SRC/SNAI2/TGFBR1/CCM2/ROCK2/MYL10/CTNNA1/AFDN/TCF7/EGFR/NLK/PTPRM/HEG1/YES1	3.43447224828988
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	23/1503	75/9376	1.91304502106897	IDH2/PYCR1/PGAM1/PKM/ARG2/PFKL/GOT1/CPS1/ALDH18A1/PHGDH/PC/PFKP/GOT2/SDSL/TKTL1/GAPDH/ENO4/ACO2/PRPS2/ASS1/ENO1/IDH1/ASL	3.46859029678262
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	26/1503	89/9376	1.82239266784782	COL1A2/COL4A1/COL4A2/COL1A1/THBS1/LAMB3/COL6A2/COL6A3/ITGA1/COMP/TNC/LAMA4/COL6A1/THBS2/ITGA11/ITGA5/HSPG2/ITGB1/ITGAV/THBS3/DAG1/ITGA10/AGRN/ITGB3/LAMC3/LAMA2	3.40589702307269
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	54/1503	226/9376	1.49054104181018	PDE4D/PDE3A/FOS/ATP1B1/PDE4C/CALM1/CREB3L2/RYR2/CACNA1C/MYL9/GIP/SLC9A1/F2R/SOX9/JUN/CGA/PDE10A/HCAR2/NFATC1/GLI3/ATP2A2/GNAI2/AKT1/GABBR1/PRKACA/PPARA/ADCY7/ATP2A3/ADCY6/TNNI3/CAMK2G/VAV2/ABCC4/PDE3B/ROCK2/FXYD1/PIK3R2/HCAR3/CFTR/AFDN/MAP2K1/ADCY5/NFKB1/CREB3/PIK3R1/MAPK9/PIK3R3/PRKACB/ACOX1/ATP1B3/ARAP3/ACOX3/NFKBIA/HCN2	3.26147477855606
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	28/1503	99/9376	1.76433664657218	SLC22A3/FOS/CHKB/PRKCG/JUN/SLC44A1/PDGFA/HIF1A/AKT1/SLC44A3/SLC22A2/MTOR/PIP5K1A/PIP5K1C/DGKI/PCYT1A/PIK3R2/MAP2K1/TSC2/PIK3R1/DGKZ/PDGFC/MAPK9/DGKA/PIK3R3/EGFR/PLPP1/RPS6KB2	3.34036176818608
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	26/1503	90/9376	1.80214386042729	CREB3L2/SESN3/IGF1/AKT1/PRKACA/ADCY7/ADCY6/ATG101/MTOR/FOXO1/PIK3R2/ADCY5/TSC2/CAMKK2/NFKB1/CREB3/PIK3R1/PRKAG2/PIK3R3/PRKACB/PRKAA1/EHMT1/ADIPOR2/RPTOR/RPS6KB2/AKT1S1	3.34082849782122
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	14/1503	38/9376	2.29828063171902	HK1/PMM2/PGM3/UXS1/GMPPB/GFPT1/HK2/GPI/UGP2/GMPPA/GFPT2/GALK1/NAGK/PGM1	3.50371235377905
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	51/1503	214/9376	1.48667151677953	CFL1/FOS/ELOB/CALM1/LIMK1/PRKCG/IRAK1/HLA-B/JUN/GNG5/AP1S2/NFATC1/NFATC2/GNAI2/AKT1/CRK/AP1M1/PTK2/HLA-F/MAP2K3/MTOR/BAK1/ITPR2/CALR/AP1S1/PIK3R2/GNB4/NFATC4/MAP2K1/TRAF5/CD4/AP1S3/NFKB1/CYCS/PIK3R1/ATR/MAPK9/GNB5/BTRC/PIK3R3/WEE1/FADD/RBX1/CASP3/ITPR1/AP1G1/APOBEC3G/NFKBIA/APOBEC3C/RPS6KB2/GNG11	3.14660823514993
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	30/1503	110/9376	1.70132462348031	SERPINE1/ELOB/TFRC/HK1/IFNGR2/PRKCG/LDHA/IGF1/PFKL/STAT3/TEK/HIF1A/AKT1/ANGPT1/HK2/MKNK1/PFKP/MTOR/IL6/CAMK2G/PIK3R2/MAP2K1/NFKB1/PIK3R1/GAPDH/PIK3R3/RBX1/EGFR/ENO1/RPS6KB2	3.23269167381512
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	31/1503	115/9376	1.68159912059938	PDE4D/EGR1/FOS/PDE4C/CREB3L2/PRKCG/ARHGEF1/STK39/VDR/ARHGEF11/FGFR1/PTH1R/GNAI2/PRKACA/NR4A2/LRP5/ADCY7/ADCY6/ITPR2/JUND/MAP2K1/MAFB/ADCY5/AKAP13/CREB3/PRKACB/LRP6/GNA12/MMP16/EGFR/ITPR1	3.21324619751817
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	42/1503	169/9376	1.55031947938443	WIPI1/PRKCD/ATG10/VMP1/WDR45B/HIF1A/AKT1/PRKACA/GORASP2/DAPK3/ATG101/MTOR/ATG4B/MTMR4/MAP1LC3C/GORASP1/EIF2AK3/PIK3R2/MAP1LC3A/MAP2K1/TSC2/CAMKK2/MRAS/PPP2CA/PIK3R1/MAPK9/PIK3R3/PRKACB/PRKAA1/RAB8A/ATG7/NRBF2/VPS39/UBA52/ITPR1/BECN1/PIK3R4/RPTOR/TP53INP2/RPS6KB2/AKT1S1/BIRC6	3.15423589077883
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	34/1503	130/9376	1.63152669020933	COL1A2/COL4A1/ACTA2/COL4A2/COL1A1/FOS/COL3A1/CREB3L2/JUN/GNG5/GNAI2/AKT1/TGFB1/TGFBR2/PRKACA/ADCY7/SRC/ADCY6/SHC1/TGFBR1/PIK3R2/GNB4/MAP2K1/ADCY5/NFKB1/CREB3/PIK3R1/MAPK9/GNB5/PIK3R3/PRKACB/EGFR/NFKBIA/GNG11	3.1679728009409
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	42/1503	170/9376	1.54119995303511	ACTB/TGFB3/SMARCA4/WNT2B/PRKCG/CCND1/WNT11/MYC/ACTG1/AKT1/TGFB1/TGFBR2/SMARCD2/LRP5/GADD45B/MTOR/TGFB2/SHC1/GSK3B/SMARCD1/TGFBR1/SMARCD3/BAK1/GSTM4/GSTO2/PIK3R2/MAP2K1/SMARCB1/TCF7/PIK3R1/DPF1/PIK3R3/KEAP1/LRP6/RB1/EGFR/CDK6/APC2/ELK1/RPS6KB2/WNT5B/FZD1	3.11129884973314
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/1503	24/9376	2.59924595253937	EXT1/XYLT1/EXTL3/EXTL2/B3GALT6/NDST1/XYLT2/EXT2/HS6ST1/B4GALT7	3.42739086445791
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	15/1503	44/9376	2.12665577935039	CREB3L2/ARHGDIG/RAB5C/DCTN2/PRKACA/RAB11B/ADCY6/NSF/DYNLL2/CREB3/DCTN5/PRKACB/DYNC1LI2/DCTN1/AQP3	3.27284339414859
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/1503	57/9376	1.96995482718773	ELOVL5/SCD5/ACADVL/FADS2/ACSL4/ELOVL1/HSD17B4/HSD17B12/ACSL1/ACOX1/HADH/ACSL3/ACACA/CPT1A/ACOX3/ELOVL3/SCP2/ELOVL6	3.2092184733379
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	28/1503	103/9376	1.69581871854996	COL1A2/ELN/COL4A1/COL4A2/COL1A1/COL27A1/ATP1B1/COL6A2/COL6A3/COL5A2/COL3A1/COL5A3/COL14A1/COL5A1/COL15A1/COL6A1/SLC8A1/SLC7A7/DPP4/SLC1A1/MME/COL18A1/COL25A1/SLC38A2/KCNE3/COL21A1/ATP1B3/PGA5	3.10241286718323
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	39/1503	157/9376	1.54961414750118	THBS1/PANX1/PTGS2/MAPKAPK2/ADAM17/ARG2/NFATC1/NFATC2/HIF1A/ATP2A2/CRK/TGFB1/RAB5C/PPARD/PTK2/ATP2A3/DOCK1/DUSP7/CAMK2G/DNMT3A/CALR/ITGAV/NFATC4/ANO6/P2RY6/MAP2K1/BCAR1/XKR8/MFGE8/LIPA/ADAM10/ABCA1/VPS39/CASP3/DUSP5/CPT1A/STAB1/ITGB3/AGER	3.03431612315487
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	36/1503	144/9376	1.55954757152362	SCD5/MAP3K5/IRAK1/CCND1/AKT1/ACADVL/IL17RC/PPARA/MAP2K3/CXCL2/IL6/GSK3B/FOXO1/CXCL8/ALDH2/TRA2B/TRAF3/CD14/LPIN2/CAMKK2/MAP3K14/NFKB1/TCF7/MAPK9/PRKAG2/FADD/IKBKE/PRKAA1/ACOX1/CASP3/ALDH1B1/ACACA/CPT1A/ACOX3/NFKBIA/ADIPOR2	2.95641478915895
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	48/1503	205/9376	1.46064943284163	VIM/CD40/CCND2/LYN/IRAK1/HLA-B/CCND1/JUN/MYC/STAT3/AKT1/HLA-F/PSMD14/ISG15/MAP2K3/STAT2/GADD45B/PSMD2/PSMC4/SIN3A/HLA-DRA/IL6/PSMD1/CDK2/SKP2/BAK1/CALR/HLA-DPB1/TRAF3/PIK3R2/HES1/IFNAR2/TRAF5/MAP3K14/NFKB1/CYCS/PIK3R1/MAPK9/PIK3R3/FADD/IKBKE/RB1/CASP3/CDK6/NFKBIA/RELB/APAF1/BTK	2.91362816987255
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	22/1503	77/9376	1.78234008174128	TGFB3/CCND1/STAT3/RALBP1/AKT1/TGFB1/TGFBR2/GADD45B/MTOR/TGFB2/TGFBR1/BAK1/PIK3R2/MAP2K1/NFKB1/PIK3R1/MAPK9/PIK3R3/RB1/EGFR/CDK6/RPS6KB2	3.01174239651794
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	28/1503	106/9376	1.64782384915703	PLAU/CREB3L2/CCND1/IGF1/PDGFA/FGFR1/AKT1/ETV5/FGFR2/HSP90B1/MTOR/GSK3B/FOXO1/SPINT1/CDK2/ERG/PIK3R2/MAP2K1/NFKB1/TCF7/CREB3/PLAT/PIK3R1/PDGFC/PIK3R3/RB1/EGFR/NFKBIA	2.93065705626846
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	77/1503	362/9376	1.32690787853391	COL1A2/COL4A1/COL4A2/NR4A1/COL1A1/THBS1/LAMB3/COL6A2/COL6A3/IL4R/YWHAB/CREB3L2/ITGA1/COMP/TNC/CCND2/LAMA4/COL6A1/F2R/CCND1/THBS2/IGF1/GNG5/ITGA11/MYC/TEK/PDGFA/FGFR1/ITGA5/AKT1/YWHAZ/ANGPT1/PTK2/FGFR2/HSP90B1/ITGB1/MTOR/IL6/GSK3B/CDK2/ITGAV/THEM4/EFNA5/PPP2R2D/YWHAH/PIK3R2/EPHA2/PGF/GNB4/MAP2K1/TSC2/IFNAR2/NFKB1/PPP2CA/CREB3/PIK3R1/PPP2R5C/THBS3/PDGFC/GNB5/PIK3R3/PPP2R5B/IL3RA/PRKAA1/GYS1/EGFR/IL7R/CDK6/FGF1/RPTOR/ITGA10/OSMR/RPS6KB2/ITGB3/GNG11/LAMC3/LAMA2	2.77150648065359
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	28/1503	107/9376	1.63242362626771	CALM1/CREB3L2/PGAM1/PKM/LDHA/PYGB/PFKL/AKT1/PRKACA/PPARA/PFKP/CAMK2G/FOXO1/PDE3B/ITPR2/PYGM/CREB3/PHKA2/PRKAG2/PRKACB/PRKAA1/GYS1/PHKG2/ACACA/SIK2/ITPR1/PHKG1/CPT1A	2.87460738257601
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	26/1503	98/9376	1.65503007590262	CFL1/VASP/GSN/LIMK1/LYN/PRKCG/PRKCD/ARPC1B/ARPC2/AKT1/CRK/DOCK1/VAV2/PIP5K1A/DNM2/PIP5K1C/PIK3R2/ARPC5L/MAP2K1/MYO10/PIK3R1/PIK3R3/PLPP1/ACTR3B/RPS6KB2/ARPC4	2.84801385510027
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/1503	56/9376	1.89373633685011	B4GALT1/B4GALT2/MGAT1/ST6GAL2/DPM3/TMEM258/MGAT4B/RPN2/KRTCAP2/MOGS/MGAT2/STT3A/DOLK/MAN1A2/DPM1/MAN1C1/OSTC	2.93082896933224
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	24/1503	89/9376	1.68220861647492	GUCY1A1/GUCY1A2/TUBB6/GUCY1B1/PRKCG/PDGFA/TUBA1A/TUBB2A/GNAI2/PRKACA/MAP2K5/TUBA1B/ADCY7/SRC/ADCY6/TUBB4B/ITPR2/MAP2K1/ADCY5/TUBA1C/PDGFC/PRKACB/EGFR/ITPR1	2.82533196951654
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	47/1503	205/9376	1.4302192363241	ACTN1/GSN/YWHAB/CREB3L2/CCND2/EGR2/ACTN4/LYN/PKM/HLA-B/CCND1/MAPKAPK2/JUN/STAT3/MAD1L1/SRF/YWHAZ/PRKACA/HLA-F/SRC/SND1/ATP6V0D1/EGR3/CDK2/HDAC7/SKP2/BAK1/HDAC8/YWHAH/STAT5A/TRAF3/PIK3R2/HDAC3/TRAF5/NFKB1/CREB3/DLG1/PIK3R1/PIK3R3/PRKACB/CHD4/RB1/HDAC4/CASP3/CDK6/KAT2A/NFKBIA	2.72115582221045
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	21/1503	75/9376	1.74669328010645	SERPINE1/THBS1/CD82/SESN3/CCND2/ZMAT3/CCND1/IGF1/CHEK2/PPP1R13L/TNFRSF10B/GADD45B/STEAP3/CDK2/ZNF385A/TSC2/CYCS/ATR/CASP3/CDK6/APAF1	2.83663237440115
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	26/1503	99/9376	1.63831260038845	FOS/NOTCH3/CCND1/JUN/IGF1/AKT1/PRKACA/PTK2/ADCY7/SRC/ADCY6/MTOR/SHC1/JAG1/PIK3R2/MAP2K1/ADCY5/DLL4/PIK3R1/MAPK9/PIK3R3/PRKACB/RB1/EGFR/NCOR1/RPS6KB2	2.78960195883748
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	12/1503	35/9376	2.13880809808954	HK1/PMM2/TIGAR/PFKL/GMPPB/HK2/PFKP/PFKFB4/GMPPA/AKR1B1/GMDS/TKFC	2.94905509121949
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	18/1503	62/9376	1.81108750241453	HSPA8/IGF1/AKT1/PRKACA/ADCY7/ADCY6/MTOR/FOXO1/PIK3R2/ADCY5/PIK3R1/PRKAG2/PIK3R3/PRKACB/PRKAA1/RPTOR/RPS6KB2/AKT1S1	2.79956425886595
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	55/1503	250/9376	1.37240186294079	ROGDI/NCOA7/SORT1/FUCA1/HYAL2/AP1S2/BORCS7/GALNS/AP1M1/AP4M1/CTSC/AP2S1/SMPD1/ATP6V0D1/MTOR/KXD1/MEAK7/CTSF/CTSZ/OSBPL7/CTSS/WDR7/TELO2/AP1S1/AP3D1/HGSNAT/LAMTOR2/ARSG/TFE3/AP1S3/AP3B1/ENTPD4/VPS13A/ABCB9/BLOC1S1/AP2A2/LIPA/ATP6V1E2/ACP2/MAN2B1/OSBPL2/CLTCL1/SLC29A1/VPS39/GLA/AP1G1/AP5B1/SLC17A5/RPTOR/TPCN2/LGMN/AKT1S1/NAGA/TFEB/GNPTAB	2.60757386613089
Human Diseases	Substance dependence	hsa05032	Morphine addiction	24/1503	91/9376	1.64523699853041	PDE4D/PDE3A/PDE4C/PDE7B/PRKCG/GNG5/PDE10A/GNAI2/GABBR1/PDE7A/PRKACA/GRK5/PDE8A/ADCY7/ADCY6/PDE3B/GRK4/GNB4/ADCY5/PDE2A/GNB5/PRKACB/GNG11/GRK6	2.70236499848098
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	11/1503	32/9376	2.14437791084498	HK1/B4GALT1/B4GALT2/PFKL/HK2/PFKP/UGP2/AKR1B1/GLA/GALK1/PGM1	2.83317266747688
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	41/1503	178/9376	1.43688652657232	DAAM1/CCND2/WNT2B/PRKCG/APCDD1/CCND1/NKD2/WNT11/JUN/MYC/NFATC1/NFATC2/RUVBL1/PPARD/PRKACA/PRICKLE2/ROR2/LRP5/TLE2/CTBP2/CAMK2G/GSK3B/SERPINF1/MCC/ROCK2/NFATC4/TCF7/LZTS2/MAPK9/BTRC/PRKACB/DAAM2/LRP6/RBX1/NLK/TLE4/CTBP1/APC2/WNT5B/CTNNBIP1/FZD1	2.57114726934031
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	30/1503	122/9376	1.53398121789208	JUNB/FOS/CREB3L2/CACNA1C/PRKCG/IGF1/STAT3/GNAI2/AKT1/CRK/PRKACA/PTK2/MAP2K3/ADCY7/ADCY6/MTOR/SHC1/GSK3B/ITPR2/STAT5A/PIK3R2/MAP2K1/ADCY5/BCAR1/CREB3/PIK3R1/MAPK9/PIK3R3/PRKACB/ITPR1	2.59379800612069
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	17/1503	59/9376	1.79744465870519	GPX7/IDH2/GPX8/SRM/GSS/GCLM/GSTK1/RRM1/GGT7/PGD/GSTM4/GSTO2/LAP3/G6PD/GSR/ANPEP/IDH1	2.68462428407716
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	25/1503	98/9376	1.59137507298329	NR4A1/ATP1B1/CALM1/CREB3L2/CACNA1C/PRKCG/HSD3B2/CACNA1G/CAMK1D/PRKACA/NR4A2/ADCY7/ADCY6/CAMK2G/ITPR2/ADCY5/CREB3/PRKD2/LDLR/PDE2A/PRKACB/ATF1/ATP1B3/DAGLB/ITPR1	2.57124743332812
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	26/1503	103/9376	1.5746888100821	SERPINE1/FOS/TGFB3/IFNGR2/IRAK1/JUN/GNAI2/AKT1/TGFB1/TGFBR2/CCL2/CCL3/TGFB2/IL6/TGFBR1/CXCL8/CALR/PPP2R2D/PIK3R2/NFKB1/PPP2CA/PIK3R1/MAPK9/PIK3R3/FADD/NFKBIA	2.56233687236876
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	32/1503	134/9376	1.48971708324644	ACTA2/GUCY1A1/PPP1R14A/CALD1/CALM1/GUCY1A2/ACTG2/CACNA1C/MYL9/GUCY1B1/MYLK/PRKCG/PRKCD/ARHGEF1/MYH10/ARHGEF11/PTGIR/MYH9/PLA2G5/PRKACA/ADCY7/ADCY6/ITPR2/ROCK2/MAP2K1/ADCY5/PLA2G2A/MYL6/PRKACB/GNA12/ITPR1/ADM	2.4946502953814
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/1503	70/9376	1.69322307765422	ACTB/SSPN/CD40/SGCD/HLA-B/CCND1/EIF4G3/ACTG1/HLA-F/EIF4G1/HLA-DRA/HLA-DPB1/CYCS/SNTB2/SNTB1/DAG1/SGCB/CASP3/LAMA2	2.54352207266718
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	38/1503	166/9376	1.42801946308187	PDE3A/GUCY1A1/ATP1B1/VASP/CALM1/GUCY1A2/CREB3L2/CACNA1C/MYL9/GUCY1B1/MYLK/SLC8A1/NFATC1/NFATC2/ATP2A2/GNAI2/AKT1/SRF/ADCY7/ATP2A3/ADCY6/GTF2I/PDE3B/ITPR2/ROCK2/PPIF/ADRA2A/NFATC4/MAP2K1/ADCY5/SLC25A4/CREB3/PDE2A/SLC25A5/GNA12/VDAC1/ATP1B3/ITPR1	2.43098763348399
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	20/1503	76/9376	1.64162902265644	ACTB/ATP1B1/CALM1/EZR/MYLK/PRKCG/SLC9A1/ACTG1/GNAI2/PRKACA/ADCY7/ADCY6/CAMK2G/HRH2/ITPR2/CFTR/ADCY5/PRKACB/ATP1B3/ITPR1	2.45382916913654
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	28/1503	116/9376	1.50577006905729	THY1/ACTN1/ACTB/VASP/CLDN1/MYL9/EZR/MSN/ACTN4/PRKCG/VCL/ACTG1/GNAI2/PTK2/ITGB1/VAV2/SIPA1/ROCK2/CD99L2/F11R/PIK3R2/MYL10/CTNNA1/AFDN/BCAR1/PIK3R1/PIK3R3/CLDN16	2.39481311975653
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	33/1503	142/9376	1.44972027775435	FOSB/JUNB/FOS/FHL2/IFNGR2/JUN/NFATC1/NFATC2/ATP2A2/AKT1/TGFB1/TGFBR2/TNFRSF11B/STAT2/ATP2A3/TGFB2/TGFBR1/ITPR2/JUND/PIK3R2/MAP2K1/IFNAR2/MAP3K14/NFKB1/PIK3R1/MAPK9/PIK3R3/ITPR1/TYROBP/NFKBIA/RELB/ITGB3/BTK	2.35931924398169
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	34/1503	148/9376	1.43309776842711	FOS/HEYL/NOTCH3/WNT2B/CCND1/WNT11/JUN/IGF1/MYC/FGFR1/AKT1/LRP5/GADD45B/MTOR/SHC1/GSK3B/JAG1/BAK1/PIK3R2/HES1/MAP2K1/DLL4/TCF7/PIK3R1/PIK3R3/LRP6/RB1/EGFR/CDK6/FGF1/APC2/RPS6KB2/WNT5B/FZD1	2.32037412303454
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	15/1503	53/9376	1.76552555266825	ATP1B1/PRKCG/SLC8A1/VDR/PTH1R/PRKACA/DNM1/AP2S1/ADCY6/DNM2/AP2A2/PRKACB/KLK1/CLTCL1/ATP1B3	2.441826413095
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	13/1503	44/9376	1.843101675437	B4GALT1/B4GALT2/MGAT1/TMEM258/MGAT4B/RPN2/KRTCAP2/MGAT2/STT3A/MAN1A2/MAN1C1/ST3GAL3/OSTC	2.44914178724632
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/1503	31/9376	2.01231944712725	PFKL/PGLS/PFKP/PGD/GPI/IDNK/TKTL1/G6PD/PRPS2/PGM1	2.46662867962977
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	21/1503	83/9376	1.57833730130101	IDH2/CROT/DECR2/CRAT/ACSL4/GSTK1/HSD17B4/PEX10/FAR1/ACOX2/PXMP2/PEX26/ABCD3/ACSL1/ACOX1/ACSL3/PXMP4/ACOX3/PEX11G/SCP2/IDH1	2.31226329112254
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	16/1503	59/9376	1.69171261995782	CCND1/MYC/AKT1/GADD45B/GSK3B/BAK1/PIK3R2/CTNNA1/MAP2K1/TCF7/PIK3R1/PIK3R3/EGFR/ILK/APC2/ELK1	2.32867381688481
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	8/1503	23/9376	2.16980531690243	B4GALT1/B4GALT2/B3GALNT2/POMGNT1/CRPPA/FKRP/POMT2/ST3GAL3	2.4541270623703
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	28/1503	120/9376	1.45557773342204	CALM1/ARHGDIG/MAP3K5/PRKCD/IRAK1/MAPKAPK2/JUN/SORT1/FRS2/AKT1/CRK/MAGED1/MAP2K5/SHC1/CAMK2G/GSK3B/PIK3R2/RPS6KA3/MAP2K1/NFKB1/PIK3R1/IRAK3/MAPK9/PIK3R3/PSEN2/NFKBIA/SH2B1/SH2B3	2.1945043315573
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	27/1503	115/9376	1.46461858890914	FOS/CREB3L2/CACNA1C/PRKCG/GNG5/GNAI2/AKT1/PRKACA/SLC18A3/ADCY7/ADCY6/CHAT/CAMK2G/KCNQ5/ITPR2/PIK3R2/GNB4/MAP2K1/ADCY5/CREB3/PIK3R1/GNB5/PIK3R3/PRKACB/KCNJ14/ITPR1/GNG11	2.19034014127791
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/1503	32/9376	1.94943446440452	WIPI1/ATG10/ATG101/MTOR/ATG4B/PPP2CA/ATG7/BECN1/PIK3R4/RPTOR	2.35054499795902
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1503	32/9376	1.94943446440452	SEPTIN4/BIRC7/BAK1/CYCS/MAPK9/FADD/CASP3/BECN1/APAF1/BIRC6	2.35054499795902
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	40/1503	184/9376	1.35612832306402	EPHA5/SEMA4A/CFL1/ENAH/NRP1/LIMK1/BMP7/MYL9/PLXNA4/UNC5C/SEMA3G/SSH2/ROBO2/NFATC2/SEMA6B/GNAI2/PTK2/SEMA5A/EFNB2/SRC/ITGB1/UNC5B/CAMK2G/GSK3B/PLXNA2/ROCK2/EFNA5/PIK3R2/EPHA2/PARD6G/NFATC4/PIK3R1/SSH1/BMPR2/PIK3R3/EPHB3/EFNB1/ILK/ABLIM2/WNT5B	2.13159857453296
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	19/1503	75/9376	1.58034153914393	GPX7/ATP1B1/CREB3L2/GPX8/PRKCG/PAX8/CGA/PRKACA/HSP90B1/ADCY7/ADCY6/ITPR2/ADCY5/HSPA5/CREB3/PRKACB/ATP1B3/GSR/ITPR1	2.20467445201969
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/1503	28/9376	2.00513259195894	ELOVL5/ACOT7/ELOVL1/HSD17B12/ACOT2/THEM4/HADH/ELOVL3/ELOVL6	2.32722311588783
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	15/1503	56/9376	1.67094382663245	HSPA8/CXCL2/IL6/RAB1B/CXCL8/VCP/NAIP/CD14/SAR1B/NFKB1/CYCS/PYCARD/CASP3/NFKBIA/APAF1	2.20022564016976
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	18/1503	71/9376	1.58151303027747	FOS/CCND2/CCND1/CGA/STAT3/IRF1/AKT1/SRC/SHC1/GSK3B/STAT5A/PIK3R2/MAP2K1/NFKB1/PIK3R1/SOCS4/MAPK9/PIK3R3	2.14894568641982
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1503	76/9376	1.55954757152362	CALM1/PRKCG/CCND1/IGF1/PDGFA/AKT1/CAMK1D/GADD45B/MTOR/SHC1/CAMK2G/BAK1/PIK3R2/MAP2K1/PIK3R1/PIK3R3/RB1/EGFR/CDK6	2.13991902492129
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	26/1503	112/9376	1.44815131641479	LAMB3/TGFB3/CD40/HSPA8/IFNGR2/LAMA4/IRAK1/STAT3/GNAI2/AKT1/TGFB1/MAP2K3/BIRC7/ITGB1/HLA-DRA/TGFB2/HLA-DPB1/PPIF/NFKB1/CYCS/LDLR/MAPK9/CASP3/NFKBIA/LAMC3/LAMA2	2.08463208303492
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	29/1503	128/9376	1.41333998669328	PDE4D/PDE3A/GUCY1A1/PAPSS2/PDE4C/GUCY1A2/GUCY1B1/PDE7B/PDE10A/PDE7A/PDE8A/ADCY7/ADCY6/IMPDH1/RRM1/PDE3B/NME3/AMPD2/ADCY5/AK3/ENTPD4/PDE2A/NME1/PDE9A/PRPS2/PNP/ITPA/ENPP1/PGM1	2.05723307581749
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	34/1503	155/9376	1.36837722404653	THBS1/ACTB/TFRC/COMP/TUBB6/MRC2/SEC61B/HLA-B/STX18/THBS2/ACTG1/TUBA1A/TUBB2A/ITGA5/RAB5C/SEC61G/HLA-F/TUBA1B/ITGB1/ATP6V0D1/HLA-DRA/TUBB4B/CTSS/CALR/HLA-DPB1/ITGAV/CD14/TUBA1C/THBS3/ATP6V1E2/OLR1/EEA1/DYNC1LI2/ITGB3	2.02052678365705
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	41/1503	193/9376	1.32521140792681	LYN/PRKCD/GNG5/STAT3/CCL4/CXCL14/GNAI2/AKT1/CRK/PRKACA/GRK5/CCL2/PTK2/CCL3/STAT2/ADCY7/SRC/ADCY6/CXCL2/SHC1/GSK3B/VAV2/CXCL8/ROCK2/GRK4/PIK3R2/GNB4/MAP2K1/ADCY5/BCAR1/NFKB1/PIK3R1/GNB5/PIK3R3/PRKACB/GSK3A/RASGRP2/NFKBIA/CCL26/GNG11/GRK6	1.99456014463125
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	17/1503	68/9376	1.55954757152362	RUNX1/DUSP6/CCND1/MYC/STAT3/AKT1/PPARD/MTOR/STAT5A/PIK3R2/CD14/MAP2K1/NFKB1/TCF7/PIK3R1/PIK3R3/RPS6KB2	2.02329070801099
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/1503	94/9376	1.4600019818519	FOSB/FOS/PTGS2/JUN/CCL2/IL17RC/HSP90B1/CXCL2/IL6/GSK3B/CXCL8/JUND/TRAF3/TRAF5/NFKB1/MAPK9/FADD/IKBKE/CASP3/MAPK6/NFKBIA/TRAF3IP2	1.95838399106108
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	34/1503	158/9376	1.34239537802033	TGFB3/YWHAB/ANAPC11/CCND2/CCND1/E2F4/MYC/CHEK2/TGFB1/CDC14A/MAD1L1/YWHAZ/CDC7/GADD45B/TGFB2/TFDP1/GSK3B/CDK2/SKP2/HDAC8/PCNA/YWHAH/PPP2CA/ATR/PPP2R5C/PRKDC/WEE1/PPP2R5B/RB1/RBX1/CDC27/CDK6/MCM5/CDK7	1.89641371662155
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	31/1503	142/9376	1.36185844273894	DUSP1/FOS/ACTB/CALM1/THBD/SDC2/MAP3K5/JUN/ACTG1/PDGFA/AKT1/CCL2/PTK2/MAP2K5/HSP90B1/SRC/KLF2/ITGAV/GSTM4/GSTO2/PIK3R2/NFKB1/PLAT/PIK3R1/MAPK9/BMPR2/PIK3R3/KEAP1/PRKAA1/ASS1/ITGB3	1.89837912538503
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1503	54/9376	1.61730859269116	DNMT1/LDHA/SRM/GSS/GOT1/GCLM/PHGDH/KYAT3/DNMT3A/GOT2/SDSL/AHCYL1/MRI1/AGXT2	1.98764882180359
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	21/1503	90/9376	1.45557773342204	FOS/BATF3/IFNGR2/JUN/STAT3/NFATC1/NFATC2/HIF1A/AKT1/MAP2K3/EML4/MTOR/PIK3R2/MAP2K1/CD4/NFKB1/PIK3R1/PIK3R3/EGFR/NFKBIA/RPS6KB2	1.8974240779932
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1503	80/9376	1.48157019294744	PRKCG/IGF1/STAT3/PDGFA/AKT1/FGFR2/SRC/NF1/MTOR/SHC1/IL6/GSK3B/PIK3R2/MAP2K1/PIK3R1/PDGFC/PIK3R3/EGFR/RPS6KB2	1.88995531865973
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	13/1503	50/9376	1.62192947438456	THBS1/TGFB3/CD40/COMP/SDC2/THBS2/TGFB1/CCL2/TGFB2/IL6/CXCL8/THBS3/ACKR1	1.92651963064194
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	16/1503	65/9376	1.53555453196172	NR4A1/CREB3L2/CACNA1C/HSD3B2/MRAP/CACNA1G/PRKACA/PDE8A/ADCY7/ADCY6/ITPR2/ADCY5/CREB3/LDLR/PRKACB/ITPR1	1.89302877936448
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	33/1503	155/9376	1.32813083510399	NR4A1/CREB3L2/CACNA1C/WNT2B/HSD3B2/CCND1/MRAP/WNT11/CACNA1G/GNAI2/PRKACA/PDE8A/ADCY7/ADCY6/FH/CAMK2G/GSK3B/CDK2/ITPR2/AHR/MAP2K1/ADCY5/TCF7/CREB3/LDLR/PRKACB/RB1/EGFR/ITPR1/CDK6/APC2/WNT5B/FZD1	1.79977777558694
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	20/1503	86/9376	1.45074192699872	PRKCG/JUN/MYC/AKT1/CRK/PTK2/SRC/MTOR/SHC1/CAMK2G/GSK3B/STAT5A/PIK3R2/MAP2K1/PIK3R1/MAPK9/PIK3R3/EGFR/ELK1/RPS6KB2	1.83469690543639
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	32/1503	150/9376	1.33081392770016	TGFB3/WNT2B/CCND1/WNT11/MYC/AKT1/TGFB1/TGFBR2/LRP5/FGFR2/GADD45B/MTOR/TGFB2/SHC1/GSK3B/TGFBR1/CDK2/BAK1/PIK3R2/CTNNA1/MAP2K1/TCF7/PIK3R1/PIK3R3/LRP6/RB1/EGFR/FGF1/APC2/RPS6KB2/WNT5B/FZD1	1.78450468629895
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	33/1503	156/9376	1.3196171759046	CLDN1/YWHAB/CCND1/MYC/STAT3/AKT1/YWHAZ/PPARA/STAT2/GSK3B/CDK2/BAK1/PPP2R2D/YWHAH/TRAF3/PIK3R2/MAP2K1/IFNAR2/NFKB1/PPP2CA/CYCS/PIK3R1/LDLR/PIK3R3/FADD/IKBKE/RB1/EGFR/CASP3/CDK6/CLDN16/NFKBIA/APAF1	1.7588222508491
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	22/1503	97/9376	1.41484728138225	GUCY1A1/FOS/CALM1/GUCY1A2/RYR2/CACNA1C/GUCY1B1/PRKCG/CACNA1G/GNG5/GNAI2/PRKACA/ADCY7/ADCY6/CAMK2G/GNB4/ADCY5/NOS1AP/GNB5/PRKACB/ITPR1/GNG11	1.79439698524311
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	17/1503	71/9376	1.49365119526206	LYN/ADAM17/JUN/SRC/ATP6V0D1/CXCL2/CXCL8/F11R/MAP3K14/NFKB1/MAPK9/ATP6V1E2/ADAM10/EGFR/CASP3/NOD1/NFKBIA	1.82425767166078
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	36/1503	173/9376	1.29812052196186	ACTB/IFNGR2/ACTG1/AKT1/TNFRSF10B/KPNA2/RAB11B/CCL2/STAT2/HLA-DRA/IL6/CXCL8/BAK1/HLA-DPB1/TRAF3/PIK3R2/NXF1/MAP2K1/IFNAR2/SLC25A4/DNAJB1/NFKB1/CYCS/PIK3R1/PYCARD/SLC25A5/PIK3R3/FADD/IKBKE/VDAC1/CASP3/CDK6/NLRX1/NFKBIA/NUP98/APAF1	1.72919995780116
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	22/1503	98/9376	1.40041006422529	CALM1/PRKCG/ITPK1/PIP5K1A/PIP5K1C/ITPR2/MTMR4/PI4K2A/DGKI/MTMR6/PIK3R2/PIK3R1/DGKZ/DGKA/PIK3R3/PIK3C2A/IP6K2/INPP5A/ITPKB/PI4K2B/ITPKC/ITPR1	1.74094816801169
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	24/1503	109/9376	1.37354648501163	FOS/IL4R/IFNGR2/RUNX1/JUN/STAT3/NFATC1/NFATC2/HIF1A/TGFB1/TGFBR2/MTOR/HLA-DRA/IL6/TGFBR1/HLA-DPB1/IL1RAP/STAT5A/AHR/CD4/NFKB1/STAT6/MAPK9/NFKBIA	1.7138914979071
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/1503	67/9376	1.48971708324644	PGAM1/HK1/PKM/LDHA/PFKL/HK2/PFKP/GPI/ALDH2/AKR1A1/GAPDH/ALDH3B1/ENO4/ALDH1B1/ENO1/PGM1	1.75762468390191
Human Diseases	Infectious disease: viral	hsa05162	Measles	29/1503	136/9376	1.3302023404172	FOS/HSPA8/MSN/CCND2/IRAK1/CCND1/JUN/STAT3/AKT1/STAT2/IL6/GSK3B/CDK2/BAK1/STAT5A/TRAF3/PIK3R2/IFNAR2/NFKB1/CYCS/PIK3R1/MAPK9/PIK3R3/FADD/IKBKE/CASP3/CDK6/NFKBIA/APAF1	1.69476161294338
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/1503	47/9376	1.59272943474753	CACNA1C/HK1/PKM/PRKCD/CACNA1G/HK2/MTOR/PIK3R2/PIK3R1/SOCS4/MAPK9/PIK3R3	1.77984785653086
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	22/1503	99/9376	1.386264508021	CALM1/TRPV2/PRKCG/PRKCD/IGF1/PRKACA/F2RL1/MAP2K3/ADCY7/SRC/ADCY6/CAMK2G/ITPR2/IL1RAP/TRPA1/PIK3R2/ADCY5/PIK3R1/MAPK9/PIK3R3/PRKACB/ITPR1	1.68808234014029
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	23/1503	105/9376	1.36646072933498	CCZ1/ARIH1/JUN/RABGEF1/CITED2/HIF1A/RAB5C/PINK1/SRC/MTX1/MAP1LC3C/EIF2AK3/VCP/MAP1LC3A/TFE3/MRAS/TOMM40/MAPK9/UBA52/MUL1/BECN1/NLRX1/TFEB	1.64988549092345
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	31/1503	149/9376	1.29787851589885	PTGFR/AGPAT4/F2R/PDGFA/AKT1/DNM1/ADCY7/ADCY6/MTOR/SHC1/CXCL8/FCER1G/PIP5K1A/DNM2/PIP5K1C/DGKI/PIK3R2/MAP2K1/ADCY5/TSC2/MRAS/PIK3R1/CYTH3/DGKZ/PDGFC/DGKA/PIK3R3/GNA12/GRM6/EGFR/PLPP1	1.60138980050298
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	28/1503	133/9376	1.31330321812515	TGFB3/CCND2/CCND1/IGF1/STAT3/FOXO6/AKT1/TGFB1/TGFBR2/PLK3/KLF2/GADD45B/TGFB2/IL6/FOXO1/TGFBR1/CDK2/SKP2/PIK3R2/MAP2K1/PIK3R1/MAPK9/PRKAG2/PIK3R3/PRKAA1/EGFR/NLK/IL7R	1.58993438774296
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	25/1503	117/9376	1.33294664232788	ACTB/SMARCA4/CDK2AP1/ACTG1/GATAD2A/RUVBL1/SMARCD2/GATAD2B/CHD3/SMARCD1/BAZ1B/SMARCD3/BRD9/SMARCA1/TRRAP/INO80/CHRAC1/SMARCB1/SRCAP/DPF1/CDK2AP2/RUVBL2/CHD4/BAZ1A/ZNHIT1	1.58336314209635
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	43/1503	217/9376	1.2361390889496	FOS/CREB3L2/CACNA1C/PRKCG/KLF4/CCND1/JUN/MYC/STAT3/VDR/GNAI2/AKT1/KPNA3/KPNA2/PRKACA/KLF5/PPARA/HSP90B1/ADCY7/SRC/ADCY6/MTOR/KPNB1/JAG1/GSTM4/GSTO2/STAT5A/PIK3R2/RPS6KA3/AHR/MAP2K1/ADCY5/DLL4/NFKB1/CREB3/PIK3R1/PIK3R3/PRKACB/IKBKE/RB1/EGFR/CYP1B1/RPS6KB2	1.53768976453054
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1503	59/9376	1.4802485424631	PTGS2/CGA/MGLL/GNAI2/AKT1/PRKACA/ADCY7/ADCY6/PDE3B/PIK3R2/ADCY5/PIK3R1/PIK3R3/PRKACB	1.61677288250009
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	11/1503	44/9376	1.55954757152362	TDG/PARP1/PNKP/FEN1/RFC1/PCNA/POLD4/POLG2/MPG/OGG1/PARG	1.62544018034405
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	36/1503	180/9376	1.2476380572189	NECTIN2/IFNGR2/IRAK1/HLA-B/ITGA5/AKT1/CCL2/HLA-F/STAT2/SRC/MTOR/HLA-DRA/IL6/CD74/BAK1/CALR/HLA-DPB1/TRAF3/PIK3R2/NXF1/TSC2/IFNAR2/TRAF5/NFKB1/CYCS/PIK3R1/ZC3HAV1/PIK3R3/FADD/HCFC1/IKBKE/ALYREF/CASP3/NFKBIA/ITGB3/APAF1	1.46571375069202
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	32/1503	158/9376	1.26343094401913	WNT2B/PRKCG/PRR5L/WNT11/IGF1/SEC13/AKT1/CLIP1/LRP5/MTOR/GSK3B/SKP2/TELO2/PIK3R2/LAMTOR2/RPS6KA3/LPIN2/MAP2K1/TSC2/DEPDC5/PIK3R1/SLC7A5/PIK3R3/ATP6V1E2/LRP6/PRKAA1/WDR24/RPTOR/RPS6KB2/WNT5B/AKT1S1/FZD1	1.45905607286202
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	17/1503	76/9376	1.39538466925798	SCD5/SLC27A4/SORBS1/FADS2/PPARD/PPARA/ACSL4/ACOX2/OLR1/ACSL1/ACOX1/ACSL3/ILK/CPT1A/ACOX3/SCP2/ANGPTL4	1.51209873649078
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	26/1503	125/9376	1.29754357950765	MAP3K5/SGMS2/PRKCG/S1PR3/GNAI2/AKT1/DEGS1/SMPD1/ORMDL2/S1PR5/FCER1G/ROCK2/PPP2R2D/PIK3R2/MAP2K1/NFKB1/PPP2CA/PIK3R1/PPP2R5C/MAPK9/PIK3R3/PPP2R5B/GNA12/SPTSSA/S1PR2/ORMDL3	1.4632086239654
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/1503	50/9376	1.49716566866267	PYCR1/P4HA2/SRM/ARG2/GOT1/P4HA3/ALDH18A1/CNDP2/ALDH2/GOT2/LAP3/ALDH1B1	1.54004506910959
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	11/1503	45/9376	1.52489095882309	ABCC3/ABCA7/ABCC10/ABCC4/CFTR/ABCG1/ABCB9/DEFB1/ABCB8/ABCD3/ABCA1	1.54207770085209
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/1503	30/9376	1.66351740962519	IDH2/ACLY/DLST/PC/OGDH/FH/ACO2/IDH1	1.59035860958906
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	23/1503	109/9376	1.31631538146948	FOS/CD40/IRAK1/JUN/CCL4/AKT1/CCL3/MAP2K3/STAT2/IL6/CXCL8/TRAF3/PIK3R2/CD14/MAP2K1/IFNAR2/NFKB1/PIK3R1/MAPK9/PIK3R3/FADD/IKBKE/NFKBIA	1.45130596782593
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	20/1503	93/9376	1.34154629808483	EGR1/CALM1/CACNA1C/PRKCD/JUN/CGA/PRKACA/MAP2K3/ADCY7/SRC/ADCY6/CAMK2G/ITPR2/MAP2K1/ADCY5/MAPK9/PRKACB/EGFR/ITPR1/ELK1	1.44624504604806
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1503	16/9376	1.94943446440452	B3GALNT1/ST3GAL2/GLA/GBGT1/NAGA	1.66066511334558
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	31/1503	154/9376	1.25573960304499	CACNA2D1/ATP1B1/TPM4/SCN7A/CALM1/CREB3L2/RYR2/CACNA1C/SLC9A1/SLC8A1/TPM2/TPM1/ATP2A2/GNAI2/AKT1/PRKACA/ADCY7/ATP2A3/ADCY6/TNNI3/CAMK2G/CACNG7/PPP2R2D/ADCY5/PPP2CA/CREB3/PPP2R5C/PRKACB/PPP2R5B/ATP1B3/CACNB3	1.39810822607152
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1503	51/9376	1.46780947908105	ACTB/KDELR2/SEC61B/KDELR3/ACTG1/PRKACA/SEC61G/ATP6V0D1/CFTR/ERO1A/ATP6V1E2/PRKACB	1.46360770838524
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1503	41/9376	1.5215098258767	THBS1/CCND1/TYMP/MYC/DAPK3/SRC/CXCL8/MAP2K1/RB1/EGFR	1.46215113414808
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	29/1503	144/9376	1.25630221039403	WIPI1/MAP3K5/PRKCG/XBP1/ATP2A2/AKT1/PSMD14/ATP2A3/PSMD2/PSMC4/ATG101/MTOR/PSMD1/KCND3/ITPR2/PPIF/PIK3R2/SLC25A4/CYCS/PIK3R1/MAPK9/SLC25A5/PIK3R3/NRBF2/VDAC1/ITPR1/MCU/BECN1/PIK3R4	1.3541934303097
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/1503	78/9376	1.35960557517444	CFL1/FOS/CALM1/IRAK1/JUN/IRF1/GNAI2/ITGA5/ITGB1/IL6/CXCL8/CD14/NFKB1/PYCARD/MAPK9/CASP3/NOD1	1.39339404270728
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/1503	36/9376	1.55954757152362	HK1/PYGB/HK2/GPI/UGP2/PYGM/GYS1/ENPP1/PGM1	1.46963616380531
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	14/1503	62/9376	1.40862361298908	HEYL/NOTCH3/PSENEN/ADAM17/TLE2/CTBP2/JAG1/HES1/DLL4/PSEN2/DTX3/KAT2A/TLE4/CTBP1	1.41041263593313
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/1503	31/9376	1.6098555577018	SRP19/SEC61B/SEC62/SRPRA/SEC61G/HSPA5/SRP54/SRPRB	1.48598074780418
Human Diseases	Cancer: specific types	hsa05218	Melanoma	16/1503	73/9376	1.36727458325358	CCND1/IGF1/PDGFA/FGFR1/AKT1/GADD45B/BAK1/PIK3R2/MAP2K1/PIK3R1/PDGFC/PIK3R3/RB1/EGFR/CDK6/FGF1	1.37637189836583
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/1503	52/9376	1.43958237371411	PTGS2/HSD3B2/CGA/IGF1/PRKACA/ADCY7/ADCY6/ACOT2/ADCY5/LDLR/PRKACB/CYP1B1	1.38878754188688
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/1503	47/9376	1.4600019818519	PKM/LDHA/PC/FH/ALDH2/ME2/AKR1A1/ACYP2/GRHPR/ALDH1B1/ACACA	1.38129388115809
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	14/1503	63/9376	1.386264508021	WNT2B/WNT11/GLI3/GADD45B/GSK3B/PTCH2/BAK1/TCF7/SUFU/KIF7/GLI2/APC2/WNT5B/FZD1	1.34401860549892
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1503	17/9376	1.83476184885132	TFRC/MYH10/NRP2/MYH9/DAG1	1.50510684928724
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1503	42/9376	1.48528340145107	TFRC/GSS/GCLM/ACSL4/STEAP3/MAP1LC3C/MAP1LC3A/ACSL1/ATG7/ACSL3	1.3771498106458
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1503	37/9376	1.51739763715812	GOT1/CPS1/RIMKLB/GFPT1/GOT2/GFPT2/ASS1/AGXT2/ASL	1.37774904341262
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1503	43/9376	1.45074192699872	ACADVL/ACSL4/ALDH2/ACSL1/ACOX1/HADH/ACSL3/ALDH1B1/CPT1A/ACOX3	1.29433458168523
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	15/1503	70/9376	1.33675506130596	STAT3/AKT1/PPARA/ACSL4/MTOR/CAMKK2/NFKB1/MAPK9/PRKAG2/PRKAA1/ACSL1/ACSL3/CPT1A/NFKBIA/ADIPOR2	1.23559638899002
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/1503	70/9376	1.33675506130596	ELOB/TGFB3/JUN/HIF1A/AKT1/CRK/TGFB1/TGFB2/FH/PIK3R2/MAP2K1/TFE3/PIK3R1/PIK3R3/RBX1	1.23559638899002
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1503	33/9376	1.51228855420472	IDH2/GOT1/DLST/OGDH/GOT2/ACO2/AGXT2/IDH1	1.28802250425328
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1503	65/9376	1.3436102154665	AGPAT4/MGLL/LCLAT1/ALDH2/DGKI/AKR1B1/LPIN2/AKR1A1/DGKZ/DGKA/TKFC/ALDH1B1/PLPP1/GLA	1.21456170743079
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/1503	28/9376	1.55954757152362	B4GALT1/B4GALT2/B3GNT2/B3GALNT1/ST3GAL4/ST3GAL3/B4GALT4	1.29554255160583
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/1503	23/9376	1.62735398767682	ARG2/GOT1/CPS1/GOT2/ASS1/ASL	1.31612190216437
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	11/1503	49/9376	1.40041006422529	B4GALT1/B3GLCT/B4GALT2/ST6GAL2/XXYLT1/GALNT16/POFUT2/GALNT10/POMT2/ST3GAL3/POGLUT1	1.22779833259351
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	22/1503	110/9376	1.2476380572189	ANAPC11/IGF1/GNAI2/AKT1/MAD1L1/PRKACA/CPEB4/ADCY7/ADCY6/CDK2/PDE3B/PIK3R2/RPS6KA3/MAP2K1/ADCY5/PIK3R1/MAPK9/STK10/PIK3R3/PRKACB/CDC27/SPDYE3	1.14146496342681
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	28/1503	144/9376	1.21298144451837	WNT2B/ID1/KLF4/WNT11/IGF1/MYC/STAT3/FGFR1/AKT1/FGFR2/GSK3B/PIK3R2/INHBA/MAP2K1/TCF7/PIK3R1/ID4/BMPR2/PIK3R3/PCGF2/JARID2/SKIL/PCGF3/APC2/LEFTY1/WNT5B/ID3/FZD1	1.1253046647598
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/1503	133/9376	1.21949584540193	FOS/CALM1/CREB3L2/CACNA1C/PRKCG/GNG5/GNAI2/AKT1/PRKACA/CAMK2G/GSK3B/CALY/ITPR2/PPP2R2D/GNB4/ADCY5/PPP2CA/CREB3/PPP2R5C/MAPK9/GNB5/PRKACB/PPP2R5B/GSK3A/ITPR1/GNG11	1.11388575789168
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/1503	105/9376	1.2476380572189	PLAU/CD40/PTGS2/LYN/IRAK1/ERC1/CCL4/PPP1R13L/PARP1/GADD45B/CXCL2/CXCL8/TRAF3/TNFSF13B/CD14/TRAF5/MAP3K14/NFKB1/NFKBIA/RELB/BTK	1.11492011257896
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/1503	73/9376	1.28181992180024	PRKCG/CCND1/STAT3/AKT1/GADD45B/EML4/BAK1/STAT5A/PIK3R2/MAP2K1/PIK3R1/PIK3R3/RB1/EGFR/CDK6	1.05612813532943
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	27/1503	142/9376	1.1861347727081	ELOB/CUL7/ANAPC11/FBXW7/TRIM37/UBE2E2/UBE2O/BIRC7/UBE2J1/RHOBTB2/UBE2E3/HERC2/SKP2/MGRN1/FBXW8/UBE2Q2/UBE2N/BTRC/KEAP1/RBX1/UBA52/CDC27/PIAS3/UBE2G1/UBE2S/BIRC6/UBE4B	0.976498888191707
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1503	20/9376	1.55954757152362	GMPPB/UGP2/GMPPA/CYB5R3/GMDS	1.09446507929531
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/1503	69/9376	1.26571976819308	PDE3A/GUCY1A1/CALM1/GUCY1A2/CACNA1C/GUCY1B1/GNAI2/PRKACA/ADCY6/PDE3B/ITPR2/ADCY5/PRKACB/ITPR1	0.967917977146015
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1503	10/9376	1.87145708582834	PAPSS2/SELENBP1/ETHE1	1.20465845069682
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/1503	36/9376	1.386264508021	PRIM2/FEN1/RFC1/PCNA/POLA2/POLD4/RNASEH1/MCM5	1.01451300777946
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	26/1503	138/9376	1.17531121332215	CALM1/YWHAB/ANAPC11/IGF1/MAD1L1/YWHAZ/PRKACA/CPEB4/ADCY7/ADCY6/CAMK2G/CDK2/ITPR2/YWHAH/RPS6KA3/MAP2K1/ADCY5/PPP2CA/PPP2R5C/BTRC/PRKACB/PPP2R5B/RBX1/CDC27/ITPR1/SPDYE3	0.906473813354714
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1503	75/9376	1.2476380572189	MAP3K5/ERCC1/AKT1/BAK1/MSH3/SLC31A1/GSTM4/GSTO2/PIK3R2/CYCS/PIK3R1/PIK3R3/FADD/CASP3/APAF1	0.940758607256753
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1503	37/9376	1.3487978996961	CCND1/PAX8/MYC/GADD45B/TFG/BAK1/MAP2K1/TCF7	0.92879429308986
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	13/1503	65/9376	1.2476380572189	CACNA1C/PRKCG/CGA/CACNA1G/AKT1/GABBR1/ITPR2/PIK3R2/MAP2K1/PIK3R1/PIK3R3/ITPR1/HCN2	0.87532817146394
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	34/1503	187/9376	1.13421641565354	ANTXR1/PANX1/TRPV2/PRKCD/GBP1/JUN/GSDMD/NLRP1/AIM2/CCL2/STAT2/DHX33/CXCL2/IL6/CXCL8/ITPR2/MAP1LC3C/TRAF3/MAP1LC3A/NAIP/IFNAR2/TRAF5/NFKB1/PYCARD/DNM1L/MAPK9/FADD/IKBKE/VDAC1/ITPR1/MCU/NLRX1/NOD1/NFKBIA	0.810004285783961
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1503	21/9376	1.48528340145107	COASY/ALDH2/PPCDC/ALDH1B1/ENPP1	0.972698377057313
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1503	60/9376	1.2476380572189	PTGS2/PRKCG/MAPKAPK2/NFATC2/AKT1/PTK2/SRC/PIK3R2/MAP2K1/HSPB1/PIK3R1/PIK3R3	0.840762390332865
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/1503	60/9376	1.2476380572189	GUCY1A1/GUCY1A2/GUCY1B1/LYN/PRKCG/IGF1/GNAI2/ITPR2/MAP2K1/PPP2CA/GNA12/ITPR1	0.840762390332865
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	16/1503	83/9376	1.20254270575315	POLR2L/GSDMD/AIM2/CCL4/ZDHHC11/IL6/POLR3E/NFKB1/PYCARD/POLR3A/FADD/POLR3B/IKBKE/CASP3/NFKBIA/POLR3H	0.809790519034653
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/1503	66/9376	1.22873445029134	TGFB3/IL4R/IFNGR2/JUN/STAT3/NFATC1/TGFB1/HLA-DRA/TGFB2/IL6/HLA-DPB1/NFKB1/STAT6	0.814748763080217
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	10/1503	49/9376	1.27310005838663	FOSB/CREB3L2/JUN/GNAI2/PRKACA/ADCY5/NFKB1/CREB3/RGS9/PRKACB	0.837420999811902
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	45/1503	254/9376	1.10519119241831	P2RX1/PTGFR/CALM1/RYR2/CACNA1C/MYLK/PRKCG/ORAI2/F2R/SLC8A1/CACNA1G/PDGFA/NFATC1/NFATC2/ATP2A2/FGFR1/CAMK1D/PRKACA/FGFR2/ADCY7/ATP2A3/ASPH/CAMK2G/HRH2/ITPR2/TNNC2/PPIF/NFATC4/SLC25A4/PHKA2/PDGFC/SLC25A5/PRKACB/ITPKB/EGFR/VDAC1/ITPKC/PHKG2/ITPR1/MCU/PHKG1/FGF1/TPCN2/HRC/TFEB	0.742585056345209
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	18/1503	95/9376	1.18197289631264	FOS/TGFB3/JUN/TEK/TGFB1/ANGPT1/CCL2/CCL3/ATP6V0D1/CXCL2/HLA-DRA/TGFB2/IL6/CXCL8/HLA-DPB1/TNFSF13B/ATP6V1E2/IL11	0.778872062844176
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1503	38/9376	1.31330321812515	ATP1B1/PRKCG/IGF1/HSD11B2/PIK3R2/PIK3R1/PIK3R3/ATP1B3	0.845521629919385
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1503	44/9376	1.27599346761023	TAF13/GTF2I/GTF2H5/TAF5L/TAF10/TAF15/TAF6/TAF2/CDK7	0.801738573441779
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/1503	73/9376	1.19636526034689	MAP1B/AFF4/BICD1/ELL/NUP153/MAP1A/SMARCB1/CD4/TNPO3/BICD2/NELFB/KAT2A/APOBEC3G/APOBEC3C	0.735884372293021
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1503	85/9376	1.17424758326484	TYMP/CTPS1/UPP1/IMPDH1/RRM1/TK2/NME3/AMPD2/AK3/ENTPD4/NME1/UCK2/DCTPP1/PNP/ITPA/ENPP1	0.705082602642271
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/1503	17/9376	1.46780947908105	FMO1/GGT7/ADO/FMO3	0.843477995664603
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1503	17/9376	1.46780947908105	PAPSS2/KYAT3/SEPHS2/SEPHS1	0.843477995664603
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	25/1503	139/9376	1.12197667016088	FOS/CALM1/CREB3L2/HSPA8/PRKCD/JUN/GNAI2/AKT1/GABBR1/PRKACA/HSP90B1/ADCY7/SRC/ADCY6/SHC1/ITPR2/PIK3R2/MAP2K1/ADCY5/CREB3/PIK3R1/PIK3R3/PRKACB/EGFR/ITPR1	0.633014567450874
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1503	23/9376	1.35612832306402	MME/THOP1/ENPEP/KLK1/ANPEP	0.747119322061396
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1503	69/9376	1.17531121332215	FOSB/FOS/CALM1/CREB3L2/CACNA1C/PRKCG/JUN/PRKACA/CAMK2G/ADCY5/CREB3/ARC/PRKACB	0.63859334261682
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/1503	93/9376	1.14031435337211	FOS/NOTCH3/IL4R/IFNGR2/JUN/NFATC1/NFATC2/HLA-DRA/JAG1/HLA-DPB1/STAT5A/DLL4/CD4/NFKB1/STAT6/MAPK9/NFKBIA	0.594147673658714
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	35/1503	201/9376	1.0862520398672	PLAU/CD40/CCND2/RUNX1/DUSP6/PAX8/IGF1/ETV6/MYC/NR4A3/PDGFA/ETV5/TGFBR2/DDX5/PTK2/GADD45B/SIN3A/IL6/FOXO1/CXCL8/SPINT1/ERG/BAK1/CD14/TFE3/NFKB1/PLAT/HMGA2/TAF15/ATF1/NCOR1/ETV4/FUS/SLC45A3/ELANE	0.54008158557139
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1503	18/9376	1.386264508021	ACSL4/ACSL1/ACSL3/ACACA	0.716678769986692
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	41/1503	238/9376	1.07464622575577	CALM1/PRKCG/IGF1/KSR1/GNG5/TEK/PDGFA/RALBP1/FGFR1/AKT1/RAB5C/PLA2G5/PRKACA/ANGPT1/FGFR2/NF1/SHC1/RGL2/RASAL2/EFNA5/PIK3R2/EPHA2/PGF/GNB4/AFDN/MAP2K1/PLA2G2A/MRAS/NFKB1/PIK3R1/PDGFC/MAPK9/GNB5/PIK3R3/PRKACB/SYNGAP1/RASGRP2/EGFR/FGF1/ELK1/GNG11	0.509642641915494
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1503	41/9376	1.21720786070136	PGAM1/PHGDH/ALAS1/SARDH/SDSL/GRHPR/SRR/AGXT2	0.608983194777735
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1503	59/9376	1.163052426221	TYMP/CTPS1/UPP1/RRM1/TK2/NME3/ENTPD4/NME1/UCK2/DCTPP1/ENPP1	0.548921480923025
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1503	30/9376	1.2476380572189	ABCC3/GGH/IL6/ABCC4/FPGS/NFKB1	0.59355385502612
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	15/1503	83/9376	1.12738378664358	YAF2/CBX6/BCORL1/FOXK2/SFMBT1/TFDP1/RING1/MTF2/SCML1/E2F6/HCFC1/PCGF2/JARID2/LCOR/PCGF3	0.509295964617076
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/1503	89/9376	1.12147241098328	CACNA1C/PRKCG/GNG5/GNAI2/GABBR1/PRKACA/ADCY7/SRC/ADCY6/NSF/GNB4/SLC38A2/ADCY5/GNB5/PRKACB/GNG11	0.503071755291914
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	18/1503	101/9376	1.1117566846505	CALM1/CREB3L2/WNT2B/PRKCG/WNT11/GNAI2/PRKACA/ADCY7/ADCY6/CAMK2G/GSK3B/MAP2K1/ADCY5/TCF7/CREB3/PRKACB/WNT5B/FZD1	0.493369434272751
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/1503	78/9376	1.11967517955542	FOS/TGFB3/PTGS2/IFNGR2/IRAK1/JUN/TGFB1/ITGB1/HLA-DRA/TGFB2/HLA-DPB1/NFKB1/NFKBIA/ELK1	0.46371550878085
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	18/1503	102/9376	1.10085710931079	ATP1B1/RYR2/PRKCG/SLC9A1/SCT/ATP2A2/PLA2G5/ADCY7/ATP2A3/ADCY6/ITPR2/CFTR/ADCY5/PLA2G2A/RAB8A/ATP1B3/ITPR1/TPCN2	0.447474260978975
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1503	31/9376	1.20739166827635	CNDP2/ALDH2/ALDH3B1/ACOX1/ALDH1B1/ACOX3	0.505332815978596
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	18/1503	103/9376	1.09016917621069	MSI2/NCBP2/RNGTT/CSTF2T/CPSF3/PPP2R2D/NXF1/DDX19B/PPP2CA/ETF1/PPP2R5C/SMG6/PELO/UPF3A/PPP2R5B/ALYREF/FUS/GSPT1	0.402032893110878
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1503	122/9376	1.07378685252446	FOS/JUN/NFATC1/NFATC2/AKT1/GSK3B/VAV2/PPP2R2D/PIK3R2/MAP2K1/CD4/MAP3K14/NFKB1/PPP2CA/DLG1/PIK3R1/PPP2R5C/MAPK9/PIK3R3/PPP2R5B/NFKBIA	0.358417458410574
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	18/1503	104/9376	1.07968678028558	AGPAT4/CHKB/SGMS2/PLA2G5/CHAT/PLD3/LCLAT1/PISD/PGS1/DGKI/PCYT1A/LPIN2/PLA2G2A/LPCAT1/DGKZ/LPGAT1/DGKA/PLPP1	0.357035368880284
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1503	26/9376	1.19965197809509	FADS2/PLA2G5/PLA2G2A/ACOX1/ACOX3	0.445399257529486
Organismal Systems	Digestive system	hsa04970	Salivary secretion	16/1503	93/9376	1.07323703846787	GUCY1A1/ATP1B1/CALM1/GUCY1A2/GUCY1B1/PRKCG/SLC9A1/PRKACA/ADCY7/ADCY6/ITPR2/CST3/ADCY5/PRKACB/ATP1B3/ITPR1	0.310115216195598
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1503	63/9376	1.08920782773078	PLOD1/DLST/SMYD3/PRDM2/ALDH2/CAMKMT/HADH/KMT2B/EHMT1/ALDH1B1/SETD1A	0.310401234740927
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	11/1503	63/9376	1.08920782773078	POLR2L/ERCC1/ERCC4/CETN2/RFC1/GTF2H5/PCNA/POLR2J/POLD4/RBX1/CDK7	0.310401234740927
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	17/1503	100/9376	1.06049234863606	IL4R/TFRC/ITGA1/CD7/ITGA5/IL11RA/HLA-DRA/IL6/MME/HLA-DPB1/CD14/CD4/IL3RA/IL11/IL7R/ITGB3/ANPEP	0.265714392816154
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/1503	82/9376	1.06505687811369	HSPA8/HLA-B/HLA-F/PSME2/HLA-DRA/CD74/CTSS/CALR/HLA-DPB1/HSPA5/CD4/HSPA2/LGMN/RFX5	0.258519801530625
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	30/1503	181/9376	1.03395419106538	TGFB3/CALM1/MRC2/IFNGR2/IRAK1/KSR1/VDR/AKT1/TGFB1/RAB5C/PLK3/SRC/ATP6V0D1/HLA-DRA/TGFB2/IL6/CAMK2G/CD74/FCER1G/CTSS/HLA-DPB1/CD14/NFKB1/CYCS/MAPK9/FADD/EEA1/CASP3/APAF1/RFX5	0.20153561806841
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/1503	34/9376	1.10085710931079	POLR2L/POLR2J/POLR3E/POLR3A/POLR3B/POLR3H	0.257407410947124
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/1503	34/9376	1.10085710931079	CRY1/BHLHE41/PRKAG2/BTRC/RBX1/PRKAA1	0.257407410947124
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1503	28/9376	1.1139625510883	CBR1/ALPL/GGH/FPGS/AKR1B1	0.26386198732383
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1503	22/9376	1.13421641565354	CNDP2/ALDH2/ALDH3B1/ALDH1B1	0.275367890041656
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1503	16/9376	1.16966067864271	GOT1/GOT2/ALDH3B1	0.296755153400927
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	12/1503	72/9376	1.03969838101575	ISG15/CXCL8/TRAF3/OTUD5/NFKB1/MAPK9/ZNFX1/FADD/IKBKE/TKFC/NLRX1/NFKBIA	0.147740374582473
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	15/1503	91/9376	1.02827312408151	FOS/LYN/JUN/NFATC1/NFATC2/AKT1/GSK3B/VAV2/PIK3R2/MAP2K1/NFKB1/PIK3R1/PIK3R3/NFKBIA/BTK	0.118412770950198
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/1503	116/9376	1.0217725468603	CACNA1C/PRKCG/GRIK4/GNG5/SLC1A1/GNAI2/SLC1A2/PRKACA/ADCY7/ADCY6/ITPR2/GNB4/SLC38A2/ADCY5/GNB5/PRKACB/GRM6/ITPR1/GNG11	0.103092658228576
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1503	29/9376	1.07555004932663	LATS2/WWC1/TEAD4/FAT4/TEAD3	0.178029770752303
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	25/1503	154/9376	1.01269322826209	MTHFD1L/PMM2/CTPS1/GSS/GCLM/GMPPB/RDH11/ALPL/GGH/MTHFD2/ALAS1/UGP2/GMPPA/COASY/ALDH2/NME3/FPGS/AK3/AKR1A1/NME1/UROS/PPCDC/PDXK/ALDH1B1/VKORC1L1	0.069392877119271
NA	NA	hsa04519	Cadherin signaling	65/1503	404/9376	1.00366922919837	ACTN1/ACTB/DAAM1/ENAH/VASP/VIM/LHFPL6/YWHAB/LIMA1/DSP/ACTN4/WNT2B/LHFPL2/ARPC1B/LATS2/PSENEN/WNT11/MYO1D/PKP1/ARPC2/VCL/ACTG1/MYO1B/FGFR1/FAT1/WWC1/YWHAZ/TEAD4/PRICKLE2/LRP5/PTK2/MAP2K3/CDH13/CIB2/MYO1C/GSK3B/VAV2/PCDHGC3/ROCK2/YWHAH/CYFIP1/CTNNA1/ARPC5L/AFDN/TAOK3/MAP2K1/MRAS/NFKB1/TCF7/FAT4/MAPK9/PSEN2/ADAM10/DAAM2/LRP6/TEAD3/EGFR/ABI2/NFKBIA/APC2/ACTR3B/WNT5B/FZD1/TMC6/ARPC4	0.0329394158943148
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1503	48/9376	1.03969838101575	ATP1B1/HK1/AKT1/HK2/PIK3R2/PIK3R1/PIK3R3/ATP1B3	0.120474227003289
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1503	23/9376	1.08490265845121	RFC1/MSH3/PCNA/POLD4	0.178116741958427
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1503	86/9376	1.0155193488991	ATP1B1/CREB3L2/RYR2/CACNA1C/PRKCG/GIP/PRKACA/ADCY7/ADCY6/CAMK2G/ADCY5/CREB3/PRKACB/ATP1B3	0.0631698532886856
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	27/1503	168/9376	1.00256629597947	IL4R/CCND2/IFNGR2/CCND1/MYC/STAT3/PDGFA/AKT1/IL11RA/IL24/STAT2/MTOR/IL6/STAT5A/PIK3R2/IFNAR2/IL13RA1/STAT6/PIK3R1/SOCS4/PIK3R3/IL3RA/IL11/EGFR/IL7R/PIAS3/OSMR	0.0146647185366685
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1503	17/9376	1.10085710931079	HSD17B4/ACOX2/SCP2	0.181849142041971
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/1503	55/9376	1.02079477408819	SGMS2/DEGS1/SMPD1/CERK/B4GALT5/PLPP1/GLA/GBA2/SMPD4	0.0675770610355645
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1503	37/9376	1.01159842477208	PRKCG/LAMA4/F2RL1/IL6/THOP1/APOL1	0.0308847924443451
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/1503	69/9376	0.994494103580279	LYN/AKT1/MAP2K3/VAV2/FCER1G/PIK3R2/MAP2K1/PIK3R1/MAPK9/PIK3R3/BTK	-0.0200559264415712
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	8/1503	50/9376	0.998110445775117	CD40/TGFB1/HLA-DRA/IL6/HLA-DPB1/TNFSF13B/MAP3K14/ICOSLG	-0.00585317701979432
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1503	18/9376	1.03969838101575	FUCA1/MAN2B1/GBA2	0.073656746312508
Organismal Systems	Digestive system	hsa04976	Bile secretion	14/1503	90/9376	0.970385155614697	ATP1B1/ABCC3/SLC9A1/SCT/SLC4A5/PRKACA/ADCY7/ADCY6/ABCC4/CFTR/ADCY5/LDLR/PRKACB/ATP1B3	-0.12334210976602
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1503	12/9376	1.03969838101575	NCAM2/NECTIN4	0.0601212108776428
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1503	32/9376	0.974717232202262	LDHA/ACSS3/ACOX1/ACACA/ACOX3	-0.062593349630303
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1503	19/9376	0.984977413593865	HYAL2/GALNS/HGSNAT	-0.0286383636300988
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1503	52/9376	0.959721582476074	SORT1/LDLR/LIPA/LDLRAP1/ABCA1/VDAC1/TSPO/ANGPTL4	-0.127252974207122
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1503	78/9376	0.959721582476074	ITPK1/PIP5K1A/PIP5K1C/MTMR4/PI4K2A/MTMR6/PIK3C2A/IP6K2/INPP5A/ITPKB/PI4K2B/ITPKC	-0.156070180503433
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/1503	46/9376	0.949289826144812	PSME4/PSMD14/PSME2/PSMD2/PSMC4/PSMD1/PSMB10	-0.150635799296431
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1503	33/9376	0.945180346377951	STX18/GOSR2/STX5/STX2/VAMP5	-0.137830421860941
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1503	79/9376	0.947573208014351	SLC1A1/SLC1A2/DNM1/SLC18A3/AP2S1/ATP6V0D1/NSF/DNM2/AP2A2/ATP6V1E2/CLTCL1/STX2	-0.204451554437938
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1503	13/9376	0.959721582476074	FEN1/PRKDC	-0.0634938361161358
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/1503	67/9376	0.931073177029026	CALM1/CACNA1C/PRKCG/PRKACA/CAMK2G/ITPR2/RPS6KA3/MAP2K1/PRKACB/ITPR1	-0.247382600242586
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1503	27/9376	0.924176338680663	OXCT1/AACS/ACSM6/HADH	-0.172384834583438
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1503	61/9376	0.920388730735251	ATP1B1/ATOX1/SLC39A4/SLC8A1/VDR/HMOX2/SLC31A1/SLC26A6/ATP1B3	-0.272548024638228
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1503	48/9376	0.909736083388778	OXCT1/AACS/ALDH2/IVD/HADH/ALDH1B1/AGXT2	-0.27392743234826
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1503	48/9376	0.909736083388778	CLDN1/DPP4/CHMP1A/HSPG2/LDLR/EGFR/CLDN16	-0.27392743234826
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1503	88/9376	0.921550837718502	SERPINE1/F5/CFI/PLAU/THBD/PROCR/F2R/A2M/F13A1/C9/PLAT/F3/PLAUR	-0.32304538849315
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/1503	160/9376	0.935728542914172	NCAM2/CLDN1/CD40/VCAN/NECTIN2/SDC2/HLA-B/SDC3/CNTNAP2/PTPRS/HLA-F/PTPRD/CD276/ITGB1/HLA-DRA/HLA-DPB1/ITGAV/CD99L2/F11R/CD4/VSIR/PTPRM/ICOSLG/CLDN16	-0.358262957632408
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	16/1503	108/9376	0.924176338680663	SEC13/NCBP2/KPNA3/KPNA2/POM121C/NUP153/NUP188/KPNB1/NXF1/DDX19B/TNPO3/TNPO2/IPO13/UPF3A/ALYREF/NUP98	-0.346272991948526
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	17/1503	115/9376	0.922167259683532	DUSP1/CACNA1C/PTGS2/PRKCG/GNG5/GNAI2/PRKACA/ITPR2/GNB4/MAP2K1/ADCY5/GNB5/PRKACB/CASP3/ITPR1/APP/GNG11	-0.366924999322746
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1503	42/9376	0.89117004087064	DLST/KYAT3/ALDH2/HADH/ALDH1B1/CYP1B1	-0.308840477872188
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	25/1503	168/9376	0.928302125906916	CAPN2/IFNGR2/PYGB/CAPN1/STAT3/CHMP1A/TNFRSF10B/STAT2/PARP1/SMPD1/CAMK2G/PYGM/STAT5A/IFNAR2/TRAF5/SLC25A4/STAT6/PYCARD/DNM1L/MAPK9/SLC25A5/FADD/AIFM1/CHMP2B/VDAC1	-0.409706889487409
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1503	63/9376	0.89117004087064	PTGS2/LTC4S/CBR1/PTGR1/PLA2G5/PRXL2B/PTGES2/PLA2G2A/PTGIS	-0.378677012431071
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/1503	29/9376	0.860440039461307	CALM1/GUCA1B/RGS9/RCVRN	-0.328865804884986
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1503	43/9376	0.870445156199229	SLC27A4/PLA2G5/GOT2/PLA2G2A/ABCA1/PLPP1	-0.372025109074541
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1503	15/9376	0.831758704812597	ST3GAL2/SLC33A1	-0.284912899675361
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	11/1503	78/9376	0.879744783936401	LSM7/PFKL/TENT4B/MPHOSPH6/PFKP/TOB2/LSM1/LSM5/ENO1/TENT4A/DIS3	-0.465963025145575
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1503	37/9376	0.842998687310065	GOT1/FAH/GOT2/ALDH3B1/FAHD1	-0.418069957878412
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1503	30/9376	0.831758704812597	GPAA1/PIGQ/PIGX/PIGK	-0.403250899536821
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1503	23/9376	0.81367699383841	PDSS1/ICMT/DHDDS	-0.390885838144542
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1503	23/9376	0.81367699383841	ATP1B1/SLC25A10/ATP1B3	-0.390885838144542
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1503	38/9376	0.820814511328221	NNT/SARM1/PNP/SIRT6/ENPP1	-0.483573732010449
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1503	38/9376	0.820814511328221	CD40/CD4/IL7R/BTK/RFX5	-0.483573732010449
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1503	31/9376	0.8049277788509	PGP/GRHPR/ACO2/AGXT2	-0.47531511584699
NA	NA	hsa04981	Folate transport and metabolism	4/1503	31/9376	0.8049277788509	ABCC3/ABCC4/FPGS/SLCO2B1	-0.47531511584699
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/1503	39/9376	0.799767985396728	CD40/HLA-B/HLA-F/HLA-DRA/HLA-DPB1	-0.547465988733335
Human Diseases	Immune disease	hsa05310	Asthma	4/1503	32/9376	0.77977378576181	CD40/HLA-DRA/FCER1G/HLA-DPB1	-0.545221019148167
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/1503	82/9376	0.836830404232186	TYMP/UPP1/IMPDH1/RRM1/TK2/GSTM4/GSTO2/NME3/NME1/UCK2/ITPA	-0.648395261758651
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1503	19/9376	0.656651609062577	DLST/OGDH	-0.654543485764848
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	46/1503	323/9376	0.888411000496427	TIMP3/THBS1/NOTCH3/PLAU/SOX4/VIM/DNMT1/TNC/EZR/CCND2/PTGS2/PRKCG/IGF2BP1/CCND1/MYC/STAT3/TPM1/PDGFA/ITGA5/CRK/MTOR/TGFB2/SHC1/DNMT3A/RECK/BAK1/EFNA5/PIK3R2/MAP2K1/NFKB1/PIK3R1/HMGA2/BMPR2/PIK3R3/RDX/FSCN1/MMP16/HDAC4/EGFR/CASP3/CDK6/APC2/CYP1B1/RPTOR/SLC45A3/ITGB3	-0.891705381219409
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1503	36/9376	0.693132254010498	UGP2/CRPPA/AKR1B1/AKR1A1	-0.805979616323931
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1503	36/9376	0.693132254010498	GALNT16/ST3GAL2/GALNT10/B4GALT5	-0.805979616323931
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1503	20/9376	0.623819028609448	SQLE/LIPA	-0.73580327685323
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/1503	44/9376	0.708885259783463	HLA-B/HLA-F/HLA-DRA/HLA-DPB1/PTPRN2	-0.845664640362762
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/1503	45/9376	0.693132254010498	HLA-B/HLA-F/HLA-DRA/IL6/HLA-DPB1	-0.901547074200307
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	17/1503	133/9376	0.797362668147414	IFNGR2/PRKCG/HLA-B/NFATC1/NFATC2/MICB/TNFRSF10B/SHC1/VAV2/FCER1G/PIK3R2/MAP2K1/IFNAR2/PIK3R1/PIK3R3/CASP3/TYROBP	-1.0283330764391
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1503	12/9376	0.519849190507873	VKORC1L1	-0.727164366201656
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	41/1503	298/9376	0.85827450244924	TNFRSF12A/TNFSF15/TGFB3/IL4R/CD40/BMP7/IL32/IFNGR2/RELL1/CCL4/CXCL14/TNFRSF10B/TGFB1/TGFBR2/IL11RA/TNFRSF11B/CCL2/IL24/IL17RC/CCL3/TNFRSF10D/CXCL2/TGFB2/IL6/TGFBR1/CXCL8/ACVRL1/IL1RAP/TNFSF13B/INHBA/IFNAR2/CD4/IL13RA1/BMPR2/IL3RA/IL11/IL34/IL7R/GDF11/OSMR/CCL26	-1.08631564923102
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1503	54/9376	0.693132254010498	ERCC1/ERCC4/FAAP100/TELO2/HES1/ATR	-0.988071964309612
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/1503	54/9376	0.693132254010498	CD40/HLA-B/CGA/HLA-F/HLA-DRA/HLA-DPB1	-0.988071964309612
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	32/1503	238/9376	0.838748273760602	RPS26/FOS/NRP1/PRKCG/IRAK1/ADAM17/JUN/RPL31/STAT3/CCL2/ISG15/STAT2/RPL27A/IL6/CXCL8/F13A1/TRAF3/RPLP2/PIK3R2/C9/IFNAR2/NFKB1/PIK3R1/RPL26L1/MAPK9/PIK3R3/IKBKE/RPL37A/EGFR/RPL27/UBA52/NFKBIA	-1.10093651677663
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1503	39/9376	0.639814388317382	MTHFD1L/MTHFD2/SARDH/AHCYL1	-0.984804415108367
NA	NA	hsa04081	Hormone signaling	29/1503	219/9376	0.826061727382374	SLCO1C1/GIP/CGA/IGF1/GNG5/STAT3/PTH1R/GNAI2/PRKACA/ADCY7/SRC/ADCY6/ITGAV/ADRA2A/STAT5A/PIK3R2/GNB4/ADCY5/SLC16A2/PIK3R1/GNB5/PIK3R3/PRKACB/GNA12/PENK/HCRTR2/ADIPOR2/ITGB3/GNG11	-1.13798255866157
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1503	31/9376	0.603695834138175	ALDH2/AKR1A1/ALDH1B1	-0.965639081759783
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/1503	100/9376	0.748582834331337	CCL4/CXCL14/TNFRSF10B/CCL2/IL24/CCL3/TNFRSF10D/CXCL2/IL6/CXCL8/IL34/CCL26	-1.10435717946951
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	25/1503	195/9376	0.799767985396728	ACTB/PRKCG/GSDMD/ACTG1/AKT1/SRC/MTOR/HDAC7/HDAC8/PPIF/CLCN5/PIK3R2/HDAC3/MAP2K1/SLC25A4/NFKB1/PIK3R1/SLC25A5/PIK3R3/HDAC4/ATG7/VDAC1/ITGB3/ELANE/AGER	-1.23452767943971
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1503	15/9376	0.415879352406298	ALPL	-0.989195353499822
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1503	51/9376	0.611587282950439	PLA2G5/PLD3/PLA2G2A/LPCAT1/PLPP1	-1.21520377873766
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1503	70/9376	0.623819028609448	HSD11B1/PTGS2/CBR1/GSTK1/GSTM4/GSTO2/CYP1B1	-1.3802549783643
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1503	17/9376	0.366952369770263	CPS1	-1.14140856520329
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/1503	79/9376	0.631715472009567	HSD11B1/CBR1/GSTK1/GSTM4/GSTO2/AKR7A2/ALDH3B1/CYP1B1	-1.43621879903881
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1503	28/9376	0.44558502043532	ATP6V0D1/ATP6V1E2	-1.28365885909917
NA	NA	hsa04082	Neuroactive ligand signaling	24/1503	199/9376	0.752344557116922	P2RX1/PRKCG/GRIK4/GNG5/SLC1A1/GNAI2/SLC1A2/GABBR1/PRKACA/SLC18A3/SLC17A9/ADCY7/ADCY6/CHAT/HRH2/ADRA2A/GNB4/P2RY6/ADCY5/GNB5/PRKACB/PENK/GRM6/GNG11	-1.54283347178192
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1503	18/9376	0.346566127005249	HCFC1	-1.21238730103586
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1503	30/9376	0.415879352406298	PLA2G5/PLA2G2A	-1.40005565409976
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1503	73/9376	0.512727968720094	FMO1/GSTK1/GSTM4/GSTO2/ALDH3B1/FMO3	-1.82606573199823
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1503	46/9376	0.406838496919205	HMOX2/ALAS1/UROS	-1.76200060728655
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1503	66/9376	0.472590173188976	HSD11B1/HSD3B2/HSD11B2/HSD17B12/CYP1B1	-1.87862608139404
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1503	26/9376	0.239930395619018	HES1	-1.69562275661892
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1503	26/9376	0.239930395619018	SLC19A2	-1.69562275661892
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1503	191/9376	0.653213642522982	FOSB/CALM1/CREB3L2/GNG5/GNAI2/PRKACA/SHC1/HDAC7/HDAC8/GNB4/HDAC3/MAP2K1/ADCY5/CAMKK2/CREB3/GNB5/PRKACB/HDAC4/SLC29A1/GNG11	-2.11560268795928
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1503	68/9376	0.366952369770263	RDH11/PNPLA4/DHRS4L2/RDH10	-2.28906254473511
NA	NA	hsa04382	Cornified envelope formation	21/1503	217/9376	0.603695834138175	S100A11/COL4A1/COL4A2/LAMB3/CLDN1/DSP/SLC27A4/PCSK6/S100A4/PKP1/CAPN1/S100A16/ELOVL1/S100A10/PPP2R2D/PPP2CA/PPP2R5C/PPP2R5B/CLDN16/S100A6/GBA2	-2.58065220035051
Genetic Information Processing	Translation	hsa03010	Ribosome	21/1503	222/9376	0.590099081117045	RPS26/MRPL41/MRPL52/RPL31/MRPL23/MRPS11/RPL27A/RPLP2/MRPL36/RPL26L1/MRPS12/MRPL12/MRPL33/MRPL34/MRPL3/RPL37A/RPL27/UBA52/MRPS33/MRPL47/MRPL16	-2.70050464009069
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1503	86/9376	0.362685481749679	CACNA1C/GABBR1/PRKACA/ADCY6/PRKACB	-2.59412072493286
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/1503	41/9376	0.15215098258767	POLD4	-2.37710459301848
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	13/1503	183/9376	0.443150129613269	GNL2/REXO5/LSG1/GNL3/POP5/NXF1/MPHOSPH10/POP7/RBM28/WDR43/RPP38/TBL3/GTPBP4	-3.32376293510524
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/1503	99/9376	0.252048092367454	CFI/HLA-DRA/HLA-DPB1/DEFB1	-3.2687559439971
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/1503	143/9376	0.305365958060569	ACTN1/CD40/ACTN4/HLA-DRA/HLA-DPB1/C9/ELANE	-3.65719120510525
Genetic Information Processing	Transcription	hsa03040	Spliceosome	17/1503	243/9376	0.43641660437698	DDX46/HSPA8/LSM7/NCBP2/DDX5/TRA2B/EFTUD2/SNRPF/SNIP1/LSM5/ALYREF/PPIL1/PUF60/SNRPG/FUS/U2AF1L4/RBM25	-3.88910438676371
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	27/1503	370/9376	0.455219291147435	P2RX1/PTGFR/NPFFR2/GIP/F2R/GRIK4/CGA/S1PR3/LYPD6/SCT/PTH1R/GABBR1/PTGIR/F2RL1/S1PR5/HRH2/ADRA2A/P2RY6/LYPD6B/PENK/GRM6/TSPO/S1PR2/HCRTR2/GLP2R/APLNR/ADM	-4.67144902240429
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1503	449/9376	0.111148156545113	CALM1/SLC24A4/SLC8A1/NCALD/PRKACA/CAMK2G/PDE2A/PRKACB	-8.4332462788569