category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	67/753	238/9376	3.50526186570246	RPS26/RPS18/RPL21/RPL37A/RPL27A/RPL37/RPL36A/NFKBIA/FCGR2A/RPL41/RPS29/RPLP2/F13A1/RPL35A/RPL38/MAPK13/RPL27/RPL28/RPL34/RPL23A/RPL31/RPS21/RPS23/RPS19/TNF/RPS8/RPS27/HBEGF/RPLP1/TLR7/RPS15/TRAF3/RPL36/IL6/TLR2/RPL26/FAU/UBA52/RPL30/PRKCA/RPL35/RPS10/IKBKE/NFKB1/RPL32/RPS25/RPS12/IL1B/STAT3/RPS27A/JAK1/MAP3K7/RPL29/NLRP3/MX2/CASP1/RPL12/IL6R/RPS15A/IFNAR2/RPS14/RPL17/RPS20/MMP1/TYK2/PIK3R1/RPL13A	11.5683111889448
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	46/753	205/9376	2.79400123084896	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MAPK13/MT-ND1/COX6C/TGFB2/UQCR11/COX8A/ATP5F1E/NDUFA2/UQCRQ/PRKCA/TGFB1/COX6B1/NDUFA1/UQCRB/NFKB1/COX7B/COX7A2/NDUFB4/MT-ND2/NDUFB7/NDUFC1/NDUFA3/MT-ND6/COL1A1/MT-ATP6/CAMK2G/PTPA/COX7A1/MT-CO2/PARP1/MMP2/TGFBR2/NDUFB3/PIK3R1/PRKCD/COX6A1/NDUFB2/UQCR10/NDUFA4	7.67441453025874
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	36/753	138/9376	3.24822449333102	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MT-ND1/COX6C/UQCR11/COX8A/ATP5F1E/NDUFA2/UQCRQ/ATP5MF/COX6B1/NDUFA1/UQCRB/COX7B/COX7A2/NDUFB4/MT-ND2/NDUFB7/NDUFC1/NDUFA3/MT-ND6/MT-ATP6/COX17/COX7A1/MT-CO2/NDUFB3/COX6A1/NDUFB2/UQCR10/ATP6V1E2/NDUFA4	7.8622015414434
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	48/753	235/9376	2.54329066711876	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MAPK13/MT-ND1/COX6C/ACSL5/ADCY3/UQCR11/COX8A/ATP5F1E/NDUFA2/UQCRQ/ACSL1/MAP2K3/ATP5MF/COX6B1/NDUFA1/UQCRB/ACSL3/COX7B/COX7A2/NDUFB4/MT-ND2/PRKAG2/NDUFB7/NDUFC1/NDUFA3/MT-ND6/MT-ATP6/COX17/GRB2/NDUFAF2/RPTOR/COX7A1/MT-CO2/SMARCA4/NDUFAF6/NDUFB3/SMARCE1/COX6A1/NDUFB2/UQCR10/NDUFA4	7.08008937094469
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/753	227/9376	2.52321697059047	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/NFKBIA/MT-ND4/COX7C/MT-ND4L/HIF1A/MAPK13/MT-ND1/COX6C/UQCR11/COX8A/ATP5F1E/NDUFA2/UQCRQ/COX6B1/NDUFA1/UQCRB/GSTM4/NFKB1/COX7B/COX7A2/NDUFB4/MT-ND2/GSTO2/ABL2/NDUFB7/NDUFC1/NDUFA3/MT-ND6/MT-ATP6/GRB2/PTPRJ/COX7A1/MT-CO2/GSTO1/NDUFB3/GSTM2/PIK3R1/PRKCD/COX6A1/NDUFB2/UQCR10/NDUFA4	6.8650201723073
Genetic Information Processing	Translation	hsa03010	Ribosome	45/753	222/9376	2.52395822116938	RPS26/RPS18/RPL21/RPL37A/RPL27A/RPL37/RPL36A/RPL41/RPS29/RPLP2/RPL35A/RPL38/RPL27/RPL28/RPL34/RPL23A/RPL31/RPS21/RPS23/RPS19/RPS8/RPS27/RPLP1/RPS15/RPL36/MRPL23/RPL26/FAU/UBA52/RPL30/RPL35/RPS10/RPL32/RPS25/RPS12/RPS27A/RPL29/RPL12/RPS15A/RPS14/RPL17/MRPL52/RPS20/MRPL41/RPL13A	6.79044174161882
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	36/753	157/9376	2.85512726165402	MT-CYB/COX7C/MAPK13/COX6C/TNF/UQCR11/COX8A/NDUFA2/UQCRQ/IL6/TGFB1/COX6B1/NDUFA1/IL1A/UQCRB/NFKB1/COX7B/COX7A2/NDUFB4/IL1B/PRKAG2/SREBF1/SOCS3/NDUFB7/NDUFC1/NDUFA3/IL6R/COX7A1/NR1H3/MT-CO2/NDUFB3/PIK3R1/COX6A1/NDUFB2/UQCR10/NDUFA4	6.92684643322197
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	24/753	87/9376	3.43490406191327	ATP1B3/TPM4/MT-CYB/COX7C/COX6C/UQCR11/COX8A/UQCRQ/CACNA2D4/COX6B1/UQCRB/SLC8A1/COX7B/TPM3/COX7A2/SLC9A7/SLC8A2/ASPH/ATP1B1/COX7A1/MT-CO2/TPM1/COX6A1/UQCR10	6.74234439553724
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	32/753	142/9376	2.80597796606999	FCGR3A/NFKBIA/LCP2/FCGR2A/MAPK13/TNF/TGFB2/TGFB1/LILRB3/NFATC1/IL1A/NFKB1/FOSL1/IFNGR2/IL1B/TREM2/JAK1/SOCS3/MAP3K7/OSCAR/ITPR1/GAB2/GRB2/RELB/FCGR1A/IFNAR2/TGFBR2/ITPR2/LILRB1/TYK2/PIK3R1/LILRB2	6.40789840747846
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	39/753	205/9376	2.36882713050238	HLA-B/CD44/CCND1/HLA-E/NFKBIA/RBPJ/MAPK13/JAK3/VIM/TNF/TNFAIP3/TRAF3/IL6/TLR2/CD40/MAP2K3/NCOR2/HLA-F/ENTPD1/IKBKE/NFKB1/HLA-DQA2/STAT3/JAK1/GADD45A/MAP3K7/HLA-DRA/MYC/DDB2/LYN/BCL2/RELB/HES1/CDKN1B/IFNAR2/MDM2/PSMD12/TYK2/PIK3R1	5.85559621649126
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	47/753	275/9376	2.12807919835808	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MAPK13/MT-ND1/EGR1/COX6C/TNF/UQCR11/COX8A/ATP5F1E/NDUFA2/UQCRQ/IL6/COX6B1/CCL5/NDUFA1/IL1A/UQCRB/COX7B/COX7A2/NDUFB4/MT-ND2/IL1B/NDUFB7/NDUFC1/NDUFA3/MT-ND6/MT-ATP6/ITPR1/ATF6B/COX7A1/MT-CO2/GRIN2C/NDUFB3/ITPR2/PSMD12/PIK3R1/PRKCD/COX6A1/NDUFB2/UQCR10/NDUFA4	5.61067759862388
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	20/753	78/9376	3.19269928831682	FCGR3A/NFKBIA/FCGR2A/MAPK13/TNF/TGFB2/TLR2/ITGA4/TGFB1/IL1A/NFKB1/HLA-DQA2/IFNGR2/IL1B/JAK1/MAP3K7/HLA-DRA/PTGS2/FCGR1A/ITGB2	5.74626352971814
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	44/753	268/9376	2.04428058908644	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MT-ND1/COX6C/UQCR11/COX8A/ATP5F1E/SLC39A8/NDUFA2/UQCRQ/UBA52/COX6B1/NDUFA1/UQCRB/COX7B/COX7A2/NDUFB4/MT-ND2/RPS27A/NDUFB7/NDUFC1/NDUFA3/MT-ND6/PRKN/UBE2G2/MT-ATP6/ITPR1/SLC39A11/CAMK2G/COX7A1/MT-CO2/NDUFB3/ITPR2/PSMD12/COX6A1/NDUFB2/UQCR10/SLC11A2/NDUFA4	5.12539126935064
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	23/753	101/9376	2.83549629863385	CCND1/MAPK13/EGR1/TNF/TGFB2/IL6/PRKCA/TGFB1/NFATC1/IL1A/PIM1/COL4A2/NFKB1/IL1B/STAT3/COL1A1/BCL2/COL4A1/CDKN1B/MMP2/TGFBR2/PIK3R1/PRKCD	5.48038632607927
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	24/753	112/9376	2.6681844052362	NFKBIA/MAPK13/TNF/TGFB2/ITGA6/TLR2/CD40/ALOX5/MAP2K3/TGFB1/NFKB1/HLA-DQA2/IFNGR2/CCR5/STAT3/JAK1/MAP3K7/HLA-DRA/PIK3R5/BCL2/LY96/IL10RB/CIITA/TYK2	5.24816799361568
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	23/753	105/9376	2.72747739201922	FCER1G/NFKBIA/MAPK13/TNF/CBLB/IL6/NFATC1/PLK3/IKBKE/NFKB1/IL1B/IL23A/CARD9/NLRP3/ITPR1/IL17D/CASP1/PTGS2/RELB/MDM2/ITPR2/PIK3R1/PRKCD	5.26014437758724
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	22/753	105/9376	2.60889141845317	BCL2A1/NFKBIA/CFLAR/CXCL1/TNF/TNFAIP3/PPP1R13L/TRAF3/CD40/PLAU/CCL4L2/NFKB1/IL1B/GADD45A/MAP3K7/LYN/BCL2/LY96/PTGS2/RELB/PARP1/CD14	4.8990517549017
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	18/753	77/9376	2.91074662389403	CCND1/NFKBIA/TGFB2/RUNX1/TGFB1/NFKB1/GADD45A/MYC/CDKN2A/GAB2/DDB2/GRB2/SHC3/CDKN1B/MDM2/TGFBR2/BCR/PIK3R1	4.97489905408836
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	54/753	388/9376	1.73294451061732	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MT-ND1/COX6C/TNF/APOE/PSENEN/UQCR11/COX8A/ATP5F1E/SLC39A8/NDUFA2/UQCRQ/IL6/COX6B1/NDUFA1/NRBF2/IL1A/UQCRB/WNT5A/NFKB1/COX7B/COX7A2/NDUFB4/MT-ND2/IL1B/APP/NDUFB7/NDUFC1/NDUFA3/MT-ND6/MT-ATP6/ITPR1/SLC39A11/PTGS2/COX7A1/MT-CO2/WIPI1/GRIN2C/NDUFB3/ITPR2/PSMD12/PIK3R1/COX6A1/NDUFB2/UQCR10/SLC11A2/ATG2A/NDUFA4	4.35721871885488
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	31/753	181/9376	2.13258201081494	FCGR3A/FCER1G/FCGR2A/MAPK13/TNF/TGFB2/RIPK2/IL6/TLR2/CORO1A/TGFB1/CD74/IL1A/PLK3/NFKB1/HLA-DQA2/IRAK2/IFNGR2/IL1B/IL23A/JAK1/HLA-DRA/CARD9/BCL2/CAMK2G/FCGR1A/IL10RB/CIITA/ITGB2/CD14/SPHK1	4.54660278050805
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	22/753	109/9376	2.51315228383104	MAP3K8/NFKBIA/MAPK13/TNF/TLR7/TRAF3/IL6/TLR2/CD40/MAP2K3/CCL5/CCL4L2/IKBKE/NFKB1/IL1B/JAK1/MAP3K7/LY96/IFNAR2/TYK2/PIK3R1/CD14	4.69548263088436
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	28/753	157/9376	2.22065453684202	DUSP4/TIMD4/HIF1A/DUSP2/MAPK13/CH25H/PTGER4/DNMT3A/SCARF1/CX3CR1/PANX1/ALOX5/TGFB1/GPR132/NFATC1/ITGAV/ABCA1/CD24/DUSP16/MERTK/CASP1/CAMK2G/ATP11A/PTGS2/NR1H3/P2RY6/PPARD/SPHK1	4.55779325736481
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	27/753	149/9376	2.2563170138239	MT-ND3/MT-ND5/MT-ND4/MT-ND4L/MAPK13/MT-ND1/GNG7/GRIA4/ADCY3/NDUFA2/PRKCA/NDUFA1/NDUFB4/MT-ND2/NDUFB7/NDUFC1/NDUFA3/MT-ND6/ITPR1/PTGS2/NDUFB3/ITPR2/GABRA3/FAAH/NDUFB2/DAGLA/NDUFA4	4.56789432699577
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	16/753	66/9376	3.01855205440863	TNF/TGFB2/IL6/TLR2/TGFB1/NFATC1/IL1A/IL4R/NFKB1/HLA-DQA2/IFNGR2/IL1B/STAT3/IL23A/HLA-DRA/IL21R	4.86285157347109
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	63/753	480/9376	1.63426294820717	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MAPK13/MT-ND1/COX6C/GRIA4/DNAH17/TNF/UQCR11/COX8A/ATP5F1E/NDUFA2/UQCRQ/IL6/UBA52/MAP2K3/PRKCA/COX6B1/NDUFA1/NRBF2/TNFRSF1B/IL1A/UQCRB/WNT5A/NFKB1/COX7B/COX7A2/HIP1/ATXN1/NDUFB4/MT-ND2/IL1B/RPS27A/APP/NDUFB7/NDUFC1/NDUFA3/MT-ND6/PRKN/UBE2G2/MT-ATP6/ITPR1/BCL2/CAMK2G/PTGS2/COX7A1/MT-CO2/WIPI1/GRIN2C/NDUFB3/TOMM40L/ITPR2/PSMD12/COX6A1/NDUFB2/UQCR10/ATG2A/NDUFA4	4.2154748902247
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/753	68/9376	2.9297711116319	BCL2A1/CCND1/RUNX1/PIM1/NFKB1/STAT3/MYC/LEF1/GRB2/FCGR1A/PPARD/RUNX1T1/PER2/PIK3R1/CD14/DUSP6	4.71939146837734
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	31/753	187/9376	2.06415691955884	NFKBIA/MAPK13/CXCL1/TNF/TNFAIP3/ANTXR1/RIPK2/TRAF3/IL6/CASP5/PANX1/CCL5/CARD16/IKBKE/NFKB1/IL1B/CASP4/JAK1/MAP3K7/CARD18/CARD9/NLRP3/ITPR1/CASP1/BCL2/NAIP/IFNAR2/ITPR2/CASR/TYK2/PRKCD	4.3435645910865
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/753	98/9376	2.54112800498686	FCGR3A/LIMK2/FCGR2A/ASAP1/VASP/GSN/PRKCA/VAV2/DNM2/WAS/HCK/GAB2/LYN/VAV3/FCGR1A/LIMK1/PIK3R1/PRKCD/SPHK1/ARPC5L	4.5318810203699
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	32/753	196/9376	2.03290240398948	HLA-B/CCND1/HLA-E/NFKBIA/HIF1A/PREX1/MAPK13/CXCL1/GNG7/TRAF3/IL6/UBA52/HLA-F/NFATC1/IKBKE/NFKB1/RCAN1/CCR5/STAT3/RPS27A/JAK1/MYC/HCK/PIK3R5/ITPR1/LEF1/LYN/PTGS2/IFNAR2/ITPR2/TYK2/PIK3R1	4.31837066008974
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	44/753	308/9376	1.7787896034908	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MT-ND1/COX6C/GRIA4/DNAH17/UQCR11/COX8A/ATP5F1E/NDUFA2/UQCRQ/COX6B1/NDUFA1/NRBF2/UQCRB/SLC1A3/COX7B/COX7A2/HIP1/NDUFB4/MT-ND2/NDUFB7/NDUFC1/NDUFA3/MT-ND6/MT-ATP6/ITPR1/COX7A1/MT-CO2/POLR2L/WIPI1/NDUFB3/PSMD12/COX6A1/NDUFB2/UQCR10/ATG2A/SLC1A2/NDUFA4	4.10670664571392
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/753	109/9376	2.39891808911144	NFKBIA/HIF1A/MAPK13/JAK3/IL6/RUNX1/TGFB1/NFATC1/IL4R/NFKB1/HLA-DQA2/IFNGR2/IL1B/STAT3/IL23A/JAK1/HLA-DRA/IL6R/IL21R/TGFBR2/TYK2	4.34100100805597
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	19/753	94/9376	2.51679805600294	NFKBIA/MAPK13/CXCL1/TNF/TNFAIP3/MAPK6/TRAF3/IL6/CCL20/IKBKE/NFKB1/FOSL1/IL1B/IL17RA/MAP3K7/IL17B/IL17D/PTGS2/MMP1	4.3674188217071
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	50/753	368/9376	1.69178359027657	MT-ND3/MT-ND5/MT-ATP8/MT-CYB/MT-ND4/COX7C/MT-ND4L/MAPK13/MT-ND1/COX6C/DNAH17/TNF/UQCR11/COX8A/ATP5F1E/NDUFA2/UQCRQ/MAP2K3/COX6B1/NDUFA1/NRBF2/TNFRSF1B/UQCRB/COX7B/COX7A2/NDUFB4/MT-ND2/NDUFB7/NDUFC1/NDUFA3/MT-ND6/PRKN/MT-ATP6/CASP1/BCL2/NUP210L/COX7A1/MT-CO2/ERBB4/WIPI1/GRIN2C/NDUFB3/TOMM40L/PSMD12/COX6A1/NDUFB2/UQCR10/ATG2A/SLC1A2/NDUFA4	4.00068087205691
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	32/753	204/9376	1.95318074108794	TWIST1/CD44/CCND1/HIF1A/MAPK13/ANK2/TNF/TGFB2/HBEGF/TLR2/TIAM1/PLAU/PRKCA/VAV2/TGFB1/ITGAV/WNT5A/STAT3/MYC/SDC2/COL1A1/ITPR1/GRB2/VAV3/CAMK2G/ERBB4/MDM2/ITGA5/MMP2/HCLS1/ITPR2/PIK3R1	4.06735662405405
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	34/753	224/9376	1.88996395370897	HLA-B/CCND1/HLA-E/NFKBIA/ETS2/EGR1/JAK3/TNF/TGFB2/ADCY3/IL6/CD40/TGFB1/HLA-F/NFATC1/MAP3K1/CDKN2C/TLN2/NFKB1/FOSL1/HLA-DQA2/JAK1/HLA-DRA/MYC/ETS1/CDKN2B/MAD1L1/CDKN2A/ATF6B/TLN1/RELB/TGFBR2/ITGB2/PIK3R1	3.98375254037708
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	27/753	163/9376	2.06252291447706	NFKBIA/MAPK13/JAK3/TNF/TGFB2/TRAF3/IL6/TLR2/MAP2K3/PRKCA/TGFB1/NFATC1/MAP3K1/IKBKE/NFKB1/STAT3/JAK1/MAP3K7/MYC/DDB2/GRB2/SLC10A1/BCL2/ATF6B/TGFBR2/TYK2/PIK3R1	4.04376123588012
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/753	216/9376	1.90231665928877	NFKBIA/ABCG1/MAPK13/CXCL1/TNF/OLR1/TRAF3/IL6/TLR2/CD40/MAP2K3/PRKCA/VAV2/CCL5/NFATC1/IKBKE/NFKB1/ABCA1/IL1B/STAT3/MAP3K7/NLRP3/ITPR1/CASP1/LYN/VAV3/POU2F2/BCL2/LY96/CAMK2G/MMP1/PIK3R1/CD14	3.9645330962041
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/753	99/9376	2.3896870430735	TPM4/DMD/ITGA9/TNF/TGFB2/ITGA6/SSPN/IL6/CACNA2D4/ITGA4/TGFB1/ITGAV/SLC8A1/SNTB1/TPM3/PRKAG2/SLC8A2/TPM1/ITGA5	4.10756798822825
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	26/753	157/9376	2.06203635563902	HLA-B/CCND1/HLA-E/MAPK13/TGFB2/IL6/MAP2K3/TGFB1/HLA-F/NFATC1/IL1A/ZFP36L1/RASSF5/NFKB1/GADD45A/MYC/ETS1/CDKN2B/CDKN2A/ITPR1/MDM2/TGFBR2/ITPR2/PIK3R1/RAD9A/TRPV4	3.96552996340052
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	21/753	119/9376	2.19732833372393	MAP3K8/NFKBIA/MAPK13/CFLAR/CXCL1/TNF/TNFAIP3/TRAF3/IL6/MAP2K3/RHBDF2/CCL5/TNFRSF1B/CCL20/NFKB1/IL1B/SOCS3/MAP3K7/ATF6B/PTGS2/PIK3R1	3.8842353992019
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	28/753	180/9376	1.9369042349122	HLA-B/HLA-E/NFKBIA/TNF/TRAF3/IL6/TLR2/HLA-F/CD74/CCL5/EIF2B3/IKBKE/NFKB1/HLA-DQA2/IFNGR2/IL1B/JAK1/SOCS3/MAP3K7/HLA-DRA/CARD9/POU2F2/BCL2/IFNAR2/NECTIN2/ITGA5/TYK2/PIK3R1	3.75047181891062
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	33/753	227/9376	1.81013391368447	HLA-B/CCND1/HLA-E/NFKBIA/MAPK13/GNA12/PTGER4/GNG7/TNF/ADCY3/IL6/PRKCA/HLA-F/CCL5/NFATC1/CCL4L2/ITGAV/NFKB1/CCR5/IL1B/STAT3/JAK1/MYC/CDKN2A/ITPR1/GRB2/IL6R/ATF6B/PTGS2/IL10RB/MDM2/ITPR2/PIK3R1	3.65121041000364
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	33/753	233/9376	1.76352102320332	ATP1B3/TPM4/DMD/SDC3/ITGA9/FMNL3/VIM/ANK2/ACTN2/ITGA6/SSPN/CAPZB/ITGA4/NID1/ITGAV/COL4A2/AMPD3/TLN2/SNTB1/PDLIM2/TPM3/MYH9/SDC2/COL1A1/FMN2/FMNL2/COL4A1/ATP1B1/TLN1/TPM1/FMNL1/ITGA5/ENO3	3.4874543663472
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	35/753	253/9376	1.72254329191797	CD44/NFKBIA/SEPTIN9/MAPK13/TNF/ARHGEF2/RIPK2/HK2/ACTN1/UBA52/CCL5/TLN2/NFKB1/IL1B/RPS27A/CASP4/MAP3K7/NLRP3/ITPR1/CASP1/RPTOR/BCL2/NAIP/TLN1/TIFA/MDM2/ITGA5/WIPI1/HCLS1/TECPR1/ITPR2/PIK3R1/CD14/PRKCD/ARPC5L	3.4427796705323
Human Diseases	Infectious disease: viral	hsa05162	Measles	22/753	136/9376	2.01421763924693	CCND1/NFKBIA/JAK3/TNFAIP3/CBLB/TLR7/TRAF3/IL6/TLR2/IL1A/IKBKE/NFKB1/IL1B/STAT3/JAK1/MAP3K7/MX2/BCL2/CDKN1B/IFNAR2/TYK2/PIK3R1	3.5206152134878
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	29/753	201/9376	1.79648900253051	BCL2A1/PDGFA/ID2/REL/NFKBIZ/ETV6/IL6/CD40/TSPAN7/RUNX1/PLAU/CDKN2C/NFKB1/DOT1L/GADD45A/MYC/DDB2/FCGR1A/SPINT1/KLF3/CDKN1B/MDM2/TGFBR2/BCL6/RUNX1T1/PER2/CD14/DUSP6/ETV7	3.37309605887884
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	22/753	138/9376	1.98502607925785	NFKBIA/LCP2/FCGR2A/MAPK13/TNF/IL6/MAP2K3/ITGA4/VAV2/NFATC1/NFKB1/IL1B/WAS/MAP3K7/NLRP3/CASP1/VAV3/RHOG/ITGA5/LIMK1/PIK3R1/ARPC5L	3.44470651470779
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	28/753	193/9376	1.80643918281967	NFKBIA/PREX1/CXCL1/GNG7/JAK3/ADCY3/CX3CR1/TIAM1/VAV2/CCL5/CCL20/CCL4L2/NFKB1/CCR5/STAT3/CCL14/WAS/HCK/GRK5/PIK3R5/GRB2/LYN/VAV3/GRK7/SHC3/GRK4/PIK3R1/PRKCD	3.34512165273472
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/753	105/9376	2.13454752418896	TPM4/DMD/ITGA9/TNF/TGFB2/ADCY3/ITGA6/SSPN/CACNA2D4/ITGA4/TGFB1/ITGAV/SLC8A1/SNTB1/TPM3/SLC8A2/TPM1/ITGA5	3.45468126415958
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/753	50/9376	2.73933598937583	TNF/TGFB2/IL6/TLR2/CD40/HBA2/TGFB1/IL1B/SDC2/HBA1/ITGB2	3.6439693306467
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	17/753	100/9376	2.11675962815405	CD44/CD55/TNF/ITGA6/IL6/ITGA4/IL1A/IL4R/HLA-DQA2/IL1B/CD24/HLA-DRA/CD5/IL6R/FCGR1A/ITGA5/CD14	3.31767063410284
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/753	93/9376	2.14219823216096	CCND1/NFKBIA/ITGA6/TRAF3/ITGAV/COL4A2/NFKB1/GADD45A/MYC/CDKN2B/DDB2/BCL2/COL4A1/PTGS2/CDKN1B/PIK3R1	3.2710916764955
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/753	69/9376	2.34593991185018	FCER1G/LCP2/MAPK13/TNF/ALOX5/MAP2K3/PRKCA/VAV2/GAB2/GRB2/LYN/VAV3/PIK3R1	3.31588372646088
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/753	103/9376	2.05510643510102	SERPINB9/CXCL1/TNF/TGFB2/IL6/TLR2/ACTN1/PRKCA/TGFB1/COL4A2/NFKB1/IL1B/COL1A1/COL4A1/ITGB2/PIK3R1/CD14	3.18169604071003
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/753	70/9376	2.31242648453804	HLA-B/CCND1/HLA-E/CD55/DMD/SSPN/CD40/HLA-F/SNTB1/HLA-DQA2/ABL2/HLA-DRA/ITGB2	3.25683993705847
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/753	95/9376	2.0970993220102	CXCL1/TNF/TGFB2/IL6/TLR2/TGFB1/CCL5/IL1A/CCL20/HLA-DQA2/IL1B/IL23A/HLA-DRA/MMP1/ITGB2/ATP6V1E2	3.17588154953582
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/753	130/9376	1.91561957299009	NFKBIA/EDNRB/MAPK13/GNG7/ADCY3/PRKCA/TGFB1/COL4A2/NFKB1/ACTA2/COL1A1/RXFP1/GRB2/COL4A1/ATF6B/SHC3/MMP2/TGFBR2/MMP1/PIK3R1	3.10644545770469
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/753	56/9376	2.44583570479985	NFKBIA/CXCL1/TNF/IL6/TLR2/NFKB1/IL1B/CASP1/NAIP/ITGB2/CD14	3.20670446121508
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/753	21/9376	3.5575792069816	CSGALNACT2/CHST7/DSE/XYLT1/CHST11/CHST15	3.46713519997799
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	27/753	200/9376	1.6809561752988	NFKBIA/FCGR2A/MAPK13/GNA12/TNF/ARHGEF2/IL6/MYO5C/CLDN11/NFKB1/MYO1G/IL1B/MYH9/CASP4/MAP3K7/NLRP3/CASP1/NAIP/MYO1C/MYO1F/MYO6/MYO1A/HCLS1/SEC24A/F2R/NCK2/ARPC5L	2.87648021560268
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	28/753	212/9376	1.64454133152923	MAGI1/FPR1/PDGFA/RALGDS/DOCK4/LCP2/MAPK13/VASP/RASGRP3/ADCY3/RAPGEF1/SIPA1L1/TIAM1/MAP2K3/PRKCA/VAV2/SIPA1/RASSF5/TLN2/RAPGEF2/APBB1IP/SIPA1L2/VAV3/TLN1/AFDN/F2R/ITGB2/PIK3R1	2.80498210797686
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/753	110/9376	1.9243269346855	HIF1A/PFKFB3/MKNK1/PFKP/HK2/IL6/PRKCA/NFKB1/IFNGR2/STAT3/BCL2/IL6R/ELOB/CAMK2G/CDKN1B/ENO3/PIK3R1	2.88157373089727
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/753	44/9376	2.54690329590728	HLA-B/HLA-E/TNF/HLA-F/ICA1/IL1A/HLA-DQA2/IL1B/HLA-DRA	3.03917754115963
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	23/753	168/9376	1.70467337001202	PDGFA/CCND1/JAK3/IL6/PIM1/IL4R/IFNGR2/STAT3/IL23A/JAK1/SOCS3/MYC/OSM/GRB2/BCL2/IL6R/IL19/IL10RB/IL21R/IFNAR2/OSMR/TYK2/PIK3R1	2.72341470683344
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/753	45/9376	2.49030544488712	HLA-B/HLA-E/TNF/IL6/HLA-F/IL1A/HLA-DQA2/IL1B/HLA-DRA	2.9612248387724
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/753	78/9376	2.07525453740593	MAPK13/TNF/IL6/IL1A/NFKB1/IL1B/IL23A/NLRP3/CASP1/LY96/ITGA5/ITGB2/CD14	2.81784919910409
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/753	70/9376	2.13454752418896	NFKBIA/TNF/ACSL5/ACSL1/PCK2/TNFRSF1B/ACSL3/NFKB1/STAT3/PRKAG2/SOCS3/POMC	2.81542603018258
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/753	142/9376	1.75373622879375	PDGFA/MAPK13/TNF/ARHGEF2/IL1A/ITGAV/GSTM4/NFKB1/BMPR1A/GSTO2/IL1B/MAP3K7/SDC2/BCL2/MMP2/GSTO1/GSTM2/PIK3R1/MAP2K5/TRPV4	2.67437658204468
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	36/753	300/9376	1.49418326693227	MAP3K8/PDGFA/DUSP4/DUSP2/MAPK13/GNA12/TAOK3/MKNK1/RASGRP3/TNF/TGFB2/CACNA2D4/MAP2K3/PRKCA/TGFB1/NFATC1/MAP3K1/IL1A/NFKB1/IL1B/DUSP16/RAPGEF2/RASGRP1/GADD45A/MAP3K7/MYC/MAP3K13/GRB2/MAPKAPK5/RELB/ERBB4/TGFBR2/CD14/MAP2K5/MAP3K9/DUSP6	2.57072341394131
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/753	173/9376	1.65540535353768	NFKBIA/TNF/TLR7/TRAF3/IL6/PRKCA/CCL5/IL1A/IKBKE/NFKB1/HLA-DQA2/IFNGR2/IL1B/JAK1/SOCS3/HLA-DRA/NLRP3/MX2/CASP1/IFNAR2/CIITA/TYK2/PIK3R1	2.57111947711949
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/753	99/9376	1.88659503400539	CCND1/MAPK13/ADCY3/HBEGF/CARM1/GPER1/CDKN2C/CDKN2A/GRB2/BCL2/SHC3/CDKN1B/MDM2/MMP2/PIK3R1	2.62055359755562
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	35/753	298/9376	1.46242769414512	CXCL1/TNF/TGFB2/IL6/CX3CR1/CD40/RELT/TGFB1/CCL5/TNFRSF1B/IL1A/CCL20/CCL4L2/IL4R/BMPR1A/IFNGR2/CCR5/IL1B/IL23A/CCL14/IL17RA/IL1RN/OSM/IL17B/IL17D/RELL1/IL6R/IL19/IL1RL2/IL10RB/IL21R/IFNAR2/OSMR/TGFBR2/TNFSF15	2.39723611349219
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/753	41/9376	2.42956628769475	CCND1/HBEGF/DAPK1/MYC/CDKN2A/MDM2/MMP2/MMP1	2.71077204604285
NA	NA	hsa04517	IgSF CAM signaling	35/753	299/9376	1.4575366316229	UNC5C/MAGI1/LCP2/MAPK13/ANK2/NPHS1/ACTN1/ITGA4/PRKCA/VAV2/CD84/MYH9/UNC5B/RAPGEF2/APP/GRB2/LYN/VAV3/NTRK3/KIRREL2/CABLES1/EPB41L3/SRGAP1/ICAM3/AFDN/SLAMF6/NECTIN2/ITGA5/NRP2/PLXNA1/ITGB2/NCK2/PIK3R1/ARPC5L/CD226	2.3759879309578
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/753	93/9376	1.87442345314084	MAPK13/EGR1/CGA/ADCY3/HBEGF/MAP2K3/PRKCA/MAP3K1/ITPR1/GRB2/CAMK2G/MMP2/ITPR2/PRKCD	2.50422317139287
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/753	160/9376	1.63426294820717	HLA-B/HLA-E/SDC3/ALCAM/ITGA9/ITGA6/CD276/CD40/ITGA4/CLDN11/HLA-F/ITGAV/NEGR1/HLA-DQA2/HLA-DRA/SDC2/VSIR/ICAM3/NECTIN2/ITGB2/CD226	2.39117869996216
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/753	76/9376	1.96603061438457	PDGFA/CCND1/PRKCA/GADD45A/CDKN2A/DDB2/GRB2/SHC3/CAMK2G/MDM2/PIK3R1/CAMK1D	2.49867714805876
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/753	77/9376	1.94049774926269	RALGDS/CCND1/TGFB2/TGFB1/NFKB1/STAT3/JAK1/GADD45A/CDKN2A/DDB2/TGFBR2/PIK3R1	2.44871889588573
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/753	86/9376	1.88220760369375	DMD/ITGA9/ACTN2/ITGA6/SSPN/CACNA2D4/ITGA4/ITGAV/SLC8A1/SNTB1/SLC8A2/LEF1/ITGA5	2.42865652412107
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/753	133/9376	1.68516909804391	FCGR3A/HLA-B/FCER1G/HLA-E/LCP2/TNF/HCST/PRKCA/VAV2/NFATC1/IFNGR2/GRB2/VAV3/SHC3/IFNAR2/LAT2/ITGB2/PIK3R1	2.35164111585009
NA	NA	hsa04518	Integrin signaling	20/753	154/9376	1.61708145771891	PDGFA/CCND1/ITGA9/LIMS1/ITGA6/ACTN1/ITGA4/TGFB1/ITGAV/COL4A2/TLN2/PARVB/COL1A1/COL4A1/TLN1/ICAM3/ITGA5/ITGB2/NCK2/PIK3R1	2.28162481452605
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/753	205/9376	1.51847892980922	HLA-B/CCND1/HLA-E/NFKBIA/RBPJ/REL/JAK3/TRAF3/GSN/ACTN1/HLA-F/NFKB1/CCR5/STAT3/JAK1/CDKN2B/MAD1L1/CDKN2A/GRB2/LYN/ATF6B/CDKN1B/MDM2/PIK3R1/HDAC4	2.2179595889563
Organismal Systems	Immune system	hsa04611	Platelet activation	17/753	126/9376	1.67996795885242	FCER1G/LCP2/FCGR2A/MAPK13/VASP/ADCY3/TLN2/RASGRP1/APBB1IP/COL1A1/PIK3R5/ITPR1/LYN/TLN1/F2R/ITPR2/PIK3R1	2.27068446121639
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/753	37/9376	2.35569433975808	TNF/IL6/HBA2/PRKCA/IL1B/APOL1/HBA1	2.44155431675687
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/753	128/9376	1.65371845949535	PDE4B/ADCY3/ADA2/AK7/ENPP4/ENTPD1/AMPD3/PDE2A/PAPSS2/NME4/PDE4A/NT5E/PDE9A/NUDT16/PDE8A/PDE1C/RRM1	2.20052220931221
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/753	138/9376	1.62411224666551	FLOT1/PYGL/MKNK1/CBLB/RAPGEF1/HK2/PCK2/PRKAR1B/PHKG1/PRKAG2/SREBF1/SOCS3/GRB2/RPTOR/SHC3/PRKAR2A/PIK3R1/FBP1	2.18256507849762
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/753	30/9376	2.49030544488712	TNF/IL6/NFKB1/IL1B/MTR/FPGS	2.41588891122199
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/753	120/9376	1.66020362992475	NFKBIA/MAPK13/RAPGEF1/RIPK2/MAP3K1/IRAK3/NFKB1/IRAK2/GRB2/NTRK3/BCL2/SHC3/CAMK2G/PIK3R1/MAP2K5/PRKCD	2.1508533049815
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/753	39/9376	2.23488950182177	HLA-B/HLA-E/TNF/CD40/HLA-F/HLA-DQA2/HLA-DRA	2.28355068716316
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/753	103/9376	1.6924405936126	NFKBIA/MAPK13/CFLAR/TNF/TGFB2/IL6/TLR2/TGFB1/CCL5/NFKB1/IFNGR2/IL1B/TGFBR2/PIK3R1	2.08806943245796
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/753	75/9376	1.82622399291722	CCND1/SESN2/PPP1R13L/CD82/GADD45A/CDKN2A/ZNF385A/DDB2/BCL2/SESN3/MDM2	2.12284138260846
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/753	133/9376	1.59154859259703	CCND1/MAPK13/TGFB2/IL6/TGFB1/PCK2/PLK3/STAT3/PRKAG2/GADD45A/CDKN2B/GRB2/CDKN1B/MDM2/TGFBR2/BCL6/PIK3R1	2.03031630636277
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	19/753	154/9376	1.53622738483296	ATP1B3/TPM4/MAPK13/ADCY3/CACNA2D4/PRKCA/SLC8A1/TPM3/KCNQ1/SLC8A2/PIK3R5/BCL2/ATP1B1/ATF6B/CAMK2G/TPM1/KCNE1/ADRB2/POPDC2	1.98267131860671
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	18/753	144/9376	1.55644090305445	CCND1/NFKBIA/MAPK13/CXCL1/TNF/TRAF3/IL6/MAP2K3/IKBKE/NFKB1/IL1B/IL17RA/PRKAG2/SREBF1/MAP3K7/LEF1/LY96/CD14	1.98841178357371
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/753	49/9376	2.03290240398948	GALNT3/GALNT6/B4GALT1/ST6GAL1/XXYLT1/LFNG/COLGALT2/ST3GAL3	2.14210262343904
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/753	86/9376	1.73742240340962	CBLB/HBEGF/PRKCA/ABL2/MYC/GRB2/SHC3/CAMK2G/ERBB4/CDKN1B/NCK2/PIK3R1	2.03007288032343
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/753	87/9376	1.71745203095663	RALGDS/CCND1/TGFB2/TGFB1/GADD45A/MYC/LEF1/DDB2/GRB2/BCL2/TGFBR2/PIK3R1	1.98665267993609
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/753	99/9376	1.63504902947134	PRKCH/MAPK13/PTGER4/ADCY3/MAP2K3/PRKCA/IL1B/ITPR1/CAMK2G/ITPR2/PIK3R1/PRKCD/TRPV4	1.87704640221931
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/753	109/9376	1.5992787260743	NFKBIA/PYGL/TNF/IL6/PCK2/NFKB1/STAT3/PRKAG2/SREBF1/SOCS3/PTPA/NR1H3/PIK3R1/PRKCD	1.85962964825725
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/753	170/9376	1.46488555581595	CCND1/TGFB2/PRKCA/TGFB1/GSTM4/WNT5A/GSTO2/GADD45A/MYC/CDKN2A/LEF1/DDB2/GRB2/SHC3/SMARCA4/TGFBR2/GSTO1/SMARCE1/GSTM2/PIK3R1	1.80754434740757
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	12/753	90/9376	1.66020362992475	NFKBIA/HIF1A/MAPK13/TLR2/MAP2K3/NFATC1/NFKB1/IFNGR2/STAT3/RASGRP1/JAK1/PIK3R1	1.85968229381761
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/753	100/9376	1.61869853917663	CXCL1/TNF/IL6/CX3CR1/CCL5/TNFRSF1B/CCL20/CCL4L2/CCR5/CCL14/IL6R/IL19/IL10RB	1.83803024665347
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/753	35/9376	2.13454752418896	PFKFB3/PFKP/HK2/ENOSF1/FBP1/TKFC	1.98707363844783
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	23/753	203/9376	1.41076416828581	PDGFA/CCND1/ITGA9/VASP/ITGA6/RAPGEF1/ACTN1/ITGA4/PRKCA/VAV2/ITGAV/COL4A2/TLN2/PARVB/COL1A1/GRB2/VAV3/BCL2/COL4A1/SHC3/TLN1/ITGA5/PIK3R1	1.74839198821822
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/753	91/9376	1.64195963399151	NFKBIA/RASGRP3/VAV2/LILRB3/NFATC1/NFKB1/GRB2/LYN/VAV3/LILRB1/PIK3R1/LILRB2	1.81840826279266
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/753	72/9376	1.72937878117161	NFKBIA/MAPK13/TNF/TRAF3/MAP3K1/IKBKE/NFKB1/MAP3K7/ZNFX1/TKFC	1.83585533298382
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/753	122/9376	1.53092547841421	MAP3K8/NFKBIA/LCP2/MAPK13/TNF/CBLB/VAV2/NFATC1/NFKB1/RASGRP1/MAP3K7/GRB2/VAV3/NCK2/PIK3R1	1.74422564709194
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/753	248/9376	1.35560981878936	NFKBIA/MAPK13/TNF/RIPK2/IL6/ARL8B/CASP5/TLR2/MAP2K3/NFKB1/DNM2/IL1B/CASP4/MAP3K7/MYC/NLRP3/LEF1/FHOD1/CASP1/BCL2/NAIP/EXOC4/LY96/RHOG/MYO6/CD14/ARPC5L	1.67712603880504
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/753	54/9376	1.84467069991638	HLA-B/HLA-E/CGA/CD40/HLA-F/HLA-DQA2/HLA-DRA/TG	1.8394318133457
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/753	73/9376	1.70568866088159	CCND1/JAK3/PRKCA/RASSF5/STAT3/GADD45A/CDKN2A/DDB2/GRB2/PIK3R1	1.78861550829642
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/753	93/9376	1.60664867412072	NFKBIA/RBPJ/MAPK13/JAK3/NFATC1/IL4R/NFKB1/HLA-DQA2/IFNGR2/JAK1/HLA-DRA/TYK2	1.73735466629025
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/753	28/9376	2.2234870043635	B4GALT1/FUT4/ST3GAL6/B3GALNT1/ST3GAL3	1.91590053096624
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/753	37/9376	2.0191665769355	CCND1/TPM3/GADD45A/MYC/LEF1/DDB2	1.83548052273732
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	18/753	156/9376	1.43671467974257	CCND1/NFKBIA/CFLAR/TNF/TRAF3/CLDN11/IKBKE/NFKB1/STAT3/JAK1/SOCS3/MYC/MX2/GRB2/NR1H3/IFNAR2/TYK2/PIK3R1	1.62535623826264
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/753	75/9376	1.66020362992475	ERCC1/GSTM4/GSTO2/CDKN2A/BCL2/MDM2/XPA/GSTO1/GSTM2/PIK3R1	1.69628042584935
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/753	75/9376	1.66020362992475	ATP1B3/CGA/ADCY3/PRKCA/ITPR1/TG/ATP1B1/ATF6B/TTF2/ITPR2	1.69628042584935
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/753	168/9376	1.40820843609688	PYGL/CFLAR/JAK3/TNF/TNFAIP3/IL1A/IFNGR2/CHMP4B/IL1B/STAT3/JAK1/NLRP3/CASP1/BCL2/CAMK2G/IFNAR2/PARP1/GLUD1/TYK2	1.57763994728617
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/753	116/9376	1.50277052708705	MAPK13/VASP/ACTN1/ITGA4/PRKCA/VAV2/CLDN11/SIPA1/RASSF5/VAV3/AFDN/MMP2/ITGB2/PIK3R1	1.61007922204437
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	34/753	333/9376	1.27132710399643	MAGI1/HLA-B/CCND1/HLA-E/RBPJ/PTGER4/ITGA9/TNF/ITGA6/TRAF3/ITGA4/HLA-F/ITGAV/COL4A2/WNT5A/IKBKE/NFKB1/JAK1/HES4/MX2/COL1A1/LLGL1/GRB2/COL4A1/PTGS2/HES1/CDKN1B/IFNAR2/MDM2/ITGA5/LFNG/TYK2/PIK3R1/ATP6V1E2	1.4897485246458
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/753	170/9376	1.39164127802515	MAGI1/CCND1/VASP/ARHGEF2/TIAM1/RUNX1/ACTN1/CLDN11/MAP3K1/MICALL2/NEDD4L/MYH9/WAS/PRKAG2/RAPGEF2/LLGL1/AFDN/HCLS1/ARPC5L	1.52275967590205
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	23/753	214/9376	1.33824825309354	HLA-B/LIMK2/HLA-E/NFKBIA/MAPK13/AP1B1/GNG7/TNF/TLR2/MAP2K3/PRKCA/HLA-F/NFATC1/TNFRSF1B/NFKB1/CCR5/MAP3K7/ITPR1/BCL2/ELOB/LIMK1/ITPR2/PIK3R1	1.47911260634691
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/753	98/9376	1.52467680299211	ATP1B3/ADCY3/PRKCA/PDE2A/ITPR1/ATP1B1/ATF6B/CAMK2G/POMC/ITPR2/CAMK1D/DAGLA	1.54287822790463
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/753	226/9376	1.32228607693121	ATP1B3/NFKBIA/PDE4B/GRIA4/CGA/ADCY3/TIAM1/VAV2/NFATC1/NFKB1/PDE4A/CNGB1/VAV3/ATP1B1/CAMK2G/GLI3/HCAR2/AFDN/GRIN2C/F2R/POMC/ADRB2/PIK3R1/POPDC2	1.44923612047811
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/753	14/9376	2.6681844052362	ST3GAL1/B4GALT1/ST3GAL3	1.84577045339949
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	36/753	362/9376	1.23827342563448	MAGI1/PDGFA/CCND1/ITGA9/GNG7/JAK3/ITGA6/IL6/TLR2/ITGA4/PRKCA/PCK2/IL4R/ITGAV/COL4A2/LPAR6/NFKB1/JAK1/MYC/OSM/COL1A1/PIK3R5/GRB2/RPTOR/BCL2/IL6R/COL4A1/ATF6B/ERBB4/CDKN1B/IFNAR2/MDM2/OSMR/ITGA5/F2R/PIK3R1	1.36623387847511
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/753	80/9376	1.55644090305445	PDGFA/IL6/PRKCA/STAT3/JAK1/GRB2/BCL2/IL6R/SHC3/PIK3R1	1.47696402102424
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/753	23/9376	2.16548299555402	ATP1B3/PCK2/ATP1B1/GLUD1	1.65366801192105
Human Diseases	Immune disease	hsa05310	Asthma	5/753	32/9376	1.94555112881806	FCER1G/TNF/CD40/HLA-DQA2/HLA-DRA	1.58324281191349
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/753	91/9376	1.50512966449221	PDE4B/GNG7/ADCY3/PRKCA/PDE2A/PDE4A/GRK5/PDE8A/GRK4/PDE1C/GABRA3	1.43082509718435
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/753	71/9376	1.57836260591437	CCND1/MAPK13/CGA/NFKB1/STAT3/SOCS3/GRB2/SHC3/PIK3R1	1.4455233944721
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/753	155/9376	1.36565137300261	FCGR3A/HLA-B/HLA-E/FCGR2A/OLR1/TLR2/CORO1A/HLA-F/ITGAV/HLA-DQA2/HLA-DRA/FCGR1A/ITGA5/ITGB2/FCAR/CD14/ATP6V1E2	1.35643185333325
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/753	166/9376	1.35016560264964	ATP1B3/EDNRB/GNA12/VASP/ADCY3/ADRA2B/NFATC1/SLC8A1/PDE2A/KCNMB4/SLC8A2/PIK3R5/ITPR1/CNGB1/ATP1B1/ATF6B/ADRB2/ITPR2	1.34509093095315
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/753	93/9376	1.47276128461066	ACTN1/HEG1/WAS/MAP3K7/SNAI1/LEF1/RASIP1/PTPRJ/AFDN/NECTIN2/TGFBR2	1.35392041373894
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/753	83/9376	1.50018400294405	NFKBIA/IL6/CCL5/CCL4L2/IKBKE/NFKB1/IL1B/NLRP3/CASP1/POLR2L	1.3525234658822
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/753	115/9376	1.40756394711011	PDE4B/GNA12/EGR1/ADCY3/HBEGF/PRKCA/WNK2/PDE4A/ITPR1/BCL2/ATF6B/ITPR2/CASR	1.29948021286041
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/753	34/9376	1.83110694476994	CRY2/BHLHE41/NFIL3/PRKAG2/PER2	1.434598497358
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/753	54/9376	1.61408686242684	SMS/DNMT3A/APIP/PSAT1/IL4I1/MTR/DNMT1	1.33729145691615
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	16/753	149/9376	1.33707674893268	FCER1G/PDGFA/RALGDS/GNA12/ADCY3/PRKCA/LPAR6/DNM2/PIK3R5/GAB2/GRB2/SHC3/DGKI/F2R/PIK3R1/SPHK1	1.22559111455892
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/753	106/9376	1.40960685559648	PDGFA/CCND1/NFKBIA/PLAU/NFKB1/LEF1/GRB2/BCL2/SPINT1/CDKN1B/MDM2/PIK3R1	1.25323990681242
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	25/753	250/9376	1.24515272244356	HLA-B/AGAP3/HLA-E/DAB2/ASAP1/EPN1/CBLB/CAPZB/HLA-F/PSD3/NEDD4L/CHMP4B/CCR5/DNM2/GRK5/PSD4/RAB11FIP4/GRK7/MDM2/TGFBR2/SH3GL1/STAMBP/ARFGAP3/GRK4/ARPC5L	1.16096847182871
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/753	17/9376	2.19732833372393	CA13/CA12/GLUD1	1.4600809347373
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/753	76/9376	1.47452296078843	PLTP/ACSL5/OLR1/ACSL1/PCK2/ACSL3/NR1H3/PPARD/MMP1	1.22737277752485
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/753	76/9376	1.47452296078843	ATP1B3/ADCY3/PRKCA/KCNQ1/HRH2/ITPR1/ATP1B1/CAMK2G/ITPR2	1.22737277752485
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/753	36/9376	1.72937878117161	ST3GAL1/GALNT3/GALNT6/GCNT1/B4GALT5	1.29564156003654
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/753	56/9376	1.55644090305445	CCND1/PTCH2/SCUBE2/BCL2/GLI3/MGRN1/IQCE	1.23412467979843
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/753	98/9376	1.39762040274277	PRKCA/INPP4A/INPP4B/ITPR1/CDS1/DGKI/IPPK/PIP4K2A/ITPR2/PIK3R1/INPP5B	1.16925287884647
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/753	142/9376	1.31530217159531	CBLB/UBA52/MAP3K1/NEDD4L/ERCC8/RPS27A/SOCS3/UBE2U/PRKN/UBE2G2/DDB2/ELOB/HERC2/MGRN1/MDM2	1.11874248811393
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/753	232/9376	1.23441864725008	LIMK2/PDGFA/GNA12/ITGA9/ITGA6/GSN/TIAM1/ACTN1/ITGA4/VAV2/ITGAV/MYH9/FGD3/ABI2/VAV3/PIP4K2A/ITGA5/LIMK1/F2R/ITGB2/PIK3R1/IQGAP3/ARPC5L	1.06837070845959
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/753	110/9376	1.35834842448388	ID2/SMAD7/SKI/TNF/TGFB2/TGFB1/SKIL/BMPR1A/MYC/CDKN2B/NBL1/TGFBR2	1.11714520885678
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/753	18/9376	2.07525453740593	ACSL5/ACSL1/ACSL3	1.34930443941703
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/753	89/9376	1.39904800274557	CD44/ITGA9/ITGA6/ITGA4/ITGAV/COL4A2/COL1A1/MEPE/COL4A1/ITGA5	1.11772857851932
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/753	122/9376	1.32680208129232	MAPK13/ADCY3/MAP2K3/PRKCA/MAP3K1/STAT3/SOCS3/ITPR1/GRB2/ATF6B/SHC3/ITPR2/PIK3R1	1.07362821128048
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/753	38/9376	1.63835884532047	ATP1B3/PRKCA/NEDD4L/ATP1B1/PIK3R1	1.16515493042652
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/753	10/9376	2.49030544488712	PAPSS2/SELENBP1	1.39332408597342
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/753	59/9376	1.47729984018727	CCND1/GADD45A/MYC/LEF1/DDB2/GRB2/PIK3R1	1.08675883682081
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/753	70/9376	1.42303168279264	HIF1A/TGFB2/RAPGEF1/TGFB1/ETS1/GRB2/ELOB/PIK3R1	1.04977040267903
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/753	169/9376	1.25252049003198	HIF1A/CFLAR/STX17/ATG10/UBA52/NRBF2/DAPK1/RPS27A/MAP3K7/ITPR1/RPTOR/BCL2/VMP1/WIPI1/PIK3R1/PRKCD/ATG2A	0.978892131102742
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	24/753	250/9376	1.19534661354582	LAPTM5/AP1B1/CTSC/STX17/TLR7/SLC11A1/GGA1/ARL8B/ARSG/GAA/MEAK7/BORCS5/GALNS/GALC/GGA3/RPTOR/ACP2/DMXL2/OSBPL6/OSBPL7/SLC29A3/SLC11A2/SLC29A1/ATP6V1E2	0.925101941127387
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/753	71/9376	1.402988983035	NFKBIA/MAPK13/CXCL1/HBEGF/CCL5/NFKB1/LYN/ATP6V1E2	1.00720550868023
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/753	71/9376	1.402988983035	SLC7A5/HIF1A/PFKP/SLC16A3/HK2/MYC/NTRK3/PIK3R1	1.00720550868023
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/753	50/9376	1.49418326693227	IL6/CD40/ITGA4/TGFB1/HLA-DQA2/HLA-DRA	1.03533111452849
Cellular Processes	Cell motility	hsa04814	Motor proteins	19/753	194/9376	1.21947947043441	TPM4/MYO9B/DNAH17/CAPZB/MYO5C/MYO1G/TPM3/MYH9/ACTA2/KIFC3/TPM1/MYO1C/MYO1F/MYO6/KIFAP3/KIF26B/MYO1A/KIF17/MYO15B	0.912809303114086
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/753	61/9376	1.42886377985326	ATP1B3/ATOX1/SLC8A1/MT2A/SLC8A2/ATP1B1/SLC11A2	0.992994379032182
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/753	150/9376	1.24515272244356	CCND1/TGFB2/TGFB1/WNT5A/GADD45A/MYC/CDKN2B/LEF1/DDB2/GRB2/BCL2/SHC3/CDKN1B/TGFBR2/PIK3R1	0.894395402511841
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/753	62/9376	1.40581758985563	RBPJ/PSENEN/NCOR2/ATXN1/HES1/NUMB/LFNG	0.947354513270214
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/753	31/9376	1.60664867412072	SMOX/DPYS/ALDH3B1/ABAT	0.999729206749963
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/753	21/9376	1.7787896034908	VNN2/DPYS/PPCDC	1.05575179852456
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/753	42/9376	1.48232466957567	ACSL5/SLC39A8/ACSL1/ACSL3/SLC11A2	0.925729611098486
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/753	53/9376	1.40960685559648	ATP1B3/PRKCA/SLC8A1/DNM2/SLC8A2/ATP1B1	0.883651955268946
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/753	32/9376	1.55644090305445	PFKP/HK2/GAA/B4GALT1	0.931711710943471
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/753	32/9376	1.55644090305445	ATG10/RPTOR/WIPI1/ATG2A	0.931711710943471
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/753	99/9376	1.25773002267026	FCGR3A/FPR1/FCGR2A/FPR2/HLA-DQA2/HLA-DRA/FPR3/FCGR1A/ITGB2/FCAR	0.761785609214836
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/753	99/9376	1.25773002267026	PDGFA/RALGDS/HIF1A/PRKCA/CHKB/WAS/GRB2/DGKI/GPCPD1/PIK3R1	0.761785609214836
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/753	122/9376	1.22474038273137	ATP1B3/CCND1/HIF1A/PFKP/PRKCA/ITGAV/RCAN1/MYC/ATP1B1/SLC16A10/MDM2/PIK3R1	0.738329493374755
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/753	23/9376	1.62411224666551	B4GALT1/FUT4/ST3GAL3	0.885533690406474
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/753	78/9376	1.27707971532673	PLCH1/INPP4A/INPP4B/INPP5K/IPPK/PIP4K2A/PLCH2/INPP5B	0.726124677236913
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/753	78/9376	1.27707971532673	SEPTIN9/DNM2/SHC3/RHOG/ITGA5/HCLS1/PIK3R1/ARPC5L	0.726124677236913
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/753	24/9376	1.55644090305445	NDST2/XYLT1/HS3ST1	0.806540818788485
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/753	195/9376	1.14937174379405	FCGR3A/FPR1/FCGR2A/FPR2/MAPK13/TLR7/TLR2/PRKCA/NFKB1/AQP9/CASP4/MAP3K7/FPR3/CASP1/FCGR1A/ITGB2/PIK3R1/HDAC4	0.622866102313777
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/753	254/9376	1.12750049670086	PDGFA/EDNRB/ADCY3/PRKCA/ORAI3/NFATC1/SLC8A1/P2RX4/PHKG1/HRH2/SLC8A2/ASPH/ITPR1/NTRK3/CAMK2G/ERBB4/GRIN2C/F2R/PDE1C/ADRB2/ITPR2/CAMK1D/SPHK1	0.608748121767872
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/753	103/9376	1.20888613829472	ATP1B3/DPP4/COL4A2/SLC8A1/KCNQ1/SLC8A2/COL1A1/COL4A1/ATP1B1/SLC16A10	0.629900621455198
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/753	139/9376	1.16453132314865	ADCY3/HBEGF/GPER1/ITPR1/GRB2/BCL2/ATF6B/SHC3/MMP2/POMC/ITPR2/PIK3R1/PRKCD	0.577489978193905
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/753	47/9376	1.32463055579102	TNF/HK2/SOCS3/PIK3R1/PRKCD	0.65928730162449
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/753	116/9376	1.18074827128269	GNG7/GRIA4/ADCY3/DLGAP1/PRKCA/SLC1A3/ITPR1/GRIN2C/ITPR2/SHANK1/SLC1A2	0.578830739539953
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	13/753	140/9376	1.15621324226902	CCND1/EGR1/GNG7/ADCY3/SLC8A1/ACTA2/PRKAG2/SLC8A2/PIK3R5/ITPR1/ITPR2/HDAC4/SPHK1	0.550292806144378
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/753	59/9376	1.26625700587481	SMS/GSTM4/GSTO2/GSTO1/GSTM2/RRM1	0.60623769303246
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/753	82/9376	1.21478314384737	DPYS/GSTM4/NME4/GSTO2/GSTO1/CES2/GSTM2/RRM1	0.577244389310212
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/753	82/9376	1.21478314384737	HLA-B/HLA-E/TNF/HLA-F/CD74/HLA-DQA2/HLA-DRA/CIITA	0.577244389310212
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/753	48/9376	1.29703408587871	IL4I1/ABAT/PCCA/IVD/OXCT1	0.609658414740882
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/753	48/9376	1.29703408587871	ATP1B3/SLC2A5/HK2/ATP1B1/PIK3R1	0.609658414740882
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/753	37/9376	1.34611105129033	IL4I1/ASL/ABAT/GLUD1	0.623332934698221
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/753	154/9376	1.13195702040324	CCND1/ADCY3/CACNA2D4/PRKCA/NFATC1/RCAN1/PRKAG2/PIK3R5/ITPR1/CAMK2G/PTGS2/ITPR2/MAP2K5/CAMK1D	0.48790383901
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	21/753	238/9376	1.09866416686196	PDGFA/RALGDS/ETS2/REL/GNG7/RASGRP3/RASA3/TIAM1/PRKCA/RASSF5/NFKB1/ABL2/RASGRP1/ETS1/RASAL3/GAB2/GRB2/SHC3/AFDN/PIK3R1/PLA1A	0.455592208177066
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	14/753	155/9376	1.1246540718845	CCND1/ADCY3/CDKN2C/WNT5A/CDKN2B/CDKN2A/ITPR1/LEF1/ATF6B/CAMK2G/PDE8A/CDKN1B/POMC/ITPR2	0.462420672356196
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/753	73/9376	1.19398206261711	PDGFA/CCND1/GADD45A/CDKN2A/DDB2/MDM2/PIK3R1	0.491660621406119
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/753	16/9376	1.55644090305445	IL4I1/ALDH3B1	0.658256334340688
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/753	16/9376	1.55644090305445	ST3GAL1/B3GALNT1	0.658256334340688
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/753	85/9376	1.17190844465276	ADA2/AK7/ENTPD1/AMPD3/NME4/NT5E/NUDT16/RRM1	0.470467228606885
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/753	39/9376	1.27707971532673	MTHFD1L/MTR/SARDH/CHDH	0.512374243525345
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/753	122/9376	1.12267868417042	CCND1/PFKFB3/PFKP/TBC1D1/PCK2/PRKAG2/SREBF1/MAP3K7/RPTOR/PIK3R1/FBP1	0.403030775469025
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/753	63/9376	1.18585973566053	ERCC1/ERCC8/DDB2/POLR2L/XPA/MNAT1	0.43738584264661
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/753	63/9376	1.18585973566053	PTCH2/WNT5A/GADD45A/LEF1/DDB2/GLI3	0.43738584264661
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/753	17/9376	1.46488555581595	CH25H/AMACR	0.566904263236227
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/753	17/9376	1.46488555581595	PAPSS2/MTR	0.566904263236227
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/753	17/9376	1.46488555581595	MYH9/NRP2	0.566904263236227
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/753	52/9376	1.19726223311881	PLTP/APOC1/APOE/MYLIP/ABCA1	0.421500814239014
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/753	184/9376	1.08274149777701	UNC5C/LIMK2/SEMA3D/EPHB2/PRKCA/WNT5A/SEMA6A/UNC5B/CAMK2G/ABLIM3/SRGAP1/LIMK1/PLXNA1/NCK2/PIK3R1/EPHB1	0.334950950927842
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/753	41/9376	1.21478314384737	PSAT1/GAMT/SARDH/CHDH	0.407276071990713
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/753	137/9376	1.09064472038852	BCL2A1/NFKBIA/CFLAR/CTSC/TNF/NFKB1/GADD45A/ITPR1/BCL2/PARP1/ITPR2/PIK3R1	0.315823358028591
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/753	125/9376	1.09573439575033	FCER1G/MAPK13/GNA12/TNF/PRKCA/NFKB1/SGPP2/GAB2/BCL2/PIK3R1/SPHK1	0.318406994768692
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/753	65/9376	1.14937174379405	ADCY3/ITPR1/ATF6B/PDE8A/POMC/ITPR2	0.357092640182767
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/753	65/9376	1.14937174379405	CGA/GPER1/PRKCA/ITPR1/ITPR2/PIK3R1	0.357092640182767
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/753	90/9376	1.10680241994983	SESN2/ADCY3/NFKB1/PRKAG2/RPTOR/SESN3/ATF6B/PIK3R1	0.300844406657098
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/753	115/9376	1.08274149777701	GNG7/ADCY3/PRKCA/KCNQ1/PIK3R5/ITPR1/BCL2/CAMK2G/ITPR2/PIK3R1	0.263813666311871
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/753	67/9376	1.11506213950169	PFKP/HK2/PCK2/ALDH3B1/ENO3/FBP1	0.279300854646032
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/753	55/9376	1.13195702040324	SGPP2/GALC/CERK/B4GALT5/SPHK1	0.290025727333638
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/753	116/9376	1.0734075193479	PFKP/ME2/HK2/PGP/PSAT1/ENO3/PCCA/GLUD1/FBP1/TKFC	0.235081245371813
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/753	104/9376	1.07753600980693	PGS1/PLD4/PLB1/CHKB/CDS1/DGKI/GPCPD1/PISD/PLA1A	0.234956432190023
NA	NA	hsa04981	Folate transport and metabolism	3/753	31/9376	1.20498650559054	SLCO2B1/MTR/FPGS	0.33780836482583
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	15/753	178/9376	1.04928600205918	ROR1/CCND1/PRICKLE2/CCDC88C/PRKCA/NFATC1/WNT5A/FOSL1/MAP3K7/MYC/ANKRD6/LEF1/CAMK2G/PPARD/INVS	0.196173717758594
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/753	93/9376	1.07109911608048	ATP1B3/CST3/ADCY3/PRKCA/ITPR1/ATP1B1/ADRB2/ITPR2	0.203617656085002
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/753	44/9376	1.13195702040324	MAN1C1/MAN1B1/B4GALT1/ST3GAL3	0.259253964917465
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/753	217/9376	1.03284557622046	CCND1/ADCY3/PRKCA/GSTM4/IKBKE/NFKB1/GSTO2/STAT3/MYC/GRB2/BCL2/ATF6B/PAQR8/GSTO1/BCL6/ADRB2/GSTM2/PIK3R1	0.144656067950064
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/753	144/9376	1.03762726870297	ID2/MAPK13/JAK3/SKIL/WNT5A/JARID2/BMPR1A/STAT3/JAK1/MYC/GRB2/PIK3R1	0.13445903071103
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/753	107/9376	1.04732471981234	PYGL/PFKP/PCK2/PHKG1/PRKAG2/ITPR1/CAMK2G/ITPR2/FBP1	0.145484736701545
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/753	157/9376	1.03101817781951	ID2/CCND1/SMAD7/TGFB2/TGFB1/WNT5A/BMPR1A/MYC/SAV1/LEF1/LLGL1/TGFBR2/ITGB2	0.115818552632629
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/753	33/9376	1.13195702040324	STX11/STX17/STX6	0.22438831088024
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/753	158/9376	1.02449274631432	TFDP2/CCND1/TGFB2/CDC14B/TGFB1/CDKN2C/GADD45A/MYC/CDKN2B/MAD1L1/CDKN2A/CDKN1B/MDM2	0.0917490569700962
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/753	59/9376	1.05521417156234	DPYS/ENTPD1/NME4/NT5E/RRM1	0.125716549244114
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/753	59/9376	1.05521417156234	CGA/ADCY3/PTGS2/ADRB2/PIK3R1	0.125716549244114
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/753	97/9376	1.02693008036582	GNG7/GRIA4/ADCY3/PRKCA/ITPR1/CAMK2G/GRIN2C/PER2	0.0787819747197664
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/753	60/9376	1.03762726870297	MAPK13/PRKCA/PTGS2/PIK3R1/SPHK1	0.0864007501839114
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/753	60/9376	1.03762726870297	GNA12/PRKCA/ITPR1/LYN/ITPR2	0.0864007501839114
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/753	73/9376	1.02341319652895	BICD1/ELL/CHMP4B/CCR5/MDFIC/MX2	0.0593423257760177
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/753	86/9376	1.01349640198894	ATP1B3/ADCY3/PRKCA/KCNMB4/ATP1B1/ATF6B/CAMK2G	0.0371546613352321
NA	NA	hsa03272	Virion - Hepatitis viruses	4/753	48/9376	1.03762726870297	DPP4/CLDN11/CHMP4B/SLC10A1	0.0772294564127795
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/753	36/9376	1.03762726870297	PYGL/HK2/GAA	0.0668396920512477
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/753	23/9376	1.08274149777701	ASL/GLUD1	0.117399368891893
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/753	62/9376	1.00415542132545	ADCY3/PRKAG2/RPTOR/PIK3R1/CLPB	0.00970055819563071
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/753	50/9376	0.996122177954847	SMS/PRODH2/SMOX/GAMT	-0.00812417191879832
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/753	89/9376	0.9793336019219	PDGFA/ADCY3/PRKCA/ITPR1/GRB2/ITPR2/MAP2K5	-0.0578863284317116
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/753	51/9376	0.976590370543968	ADCY3/PRKCA/KCNQ1/ATP6V1E2	-0.0495346547647315
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/753	38/9376	0.983015307192283	JAK3/CD40/CIITA	-0.0310010563991726
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/753	117/9376	0.957809786495046	CHD3/BAZ1A/BAZ2B/CECR2/SMARCA4/BICRAL/GATAD2A/SMARCE1/BRD9	-0.135698968121971
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/753	78/9376	0.957809786495046	PFKP/BTG2/NUDT16/DIS3L/ENO3/PNPT1	-0.110565131509959
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/753	52/9376	0.957809786495046	CGA/ADCY3/ALOX5/PTGS2	-0.0901500964685201
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/753	144/9376	0.951158329644386	RBPJ/PRKCA/NRBF2/ATXN1/ITPR1/WIPI1/GRIN2C/ITPR2/PSMD12/PIK3R1/ATG2A	-0.174533094766083
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/753	105/9376	0.948687788528426	RABGEF1/HIF1A/CCZ1/TOMM7/UBA52/RPS27A/PRKN/TOMM40L	-0.156244962695734
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/753	79/9376	0.94568561198245	SYT1/SLC1A3/DNM2/CPLX1/ATP6V1E2/SLC1A2	-0.14325538426611
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/753	158/9376	0.94568561198245	SLC7A5/TNF/PRR5/SESN2/PRKCA/WNT5A/GRB2/RPTOR/MAPKAP1/CLIP1/PIK3R1/ATP6V1E2	-0.203459988380494
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/753	26/9376	0.957809786495046	PLB1/CUBN	-0.0636570523899955
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/753	67/9376	0.929218449584746	PRKCA/ITPR1/CAMK2G/GRIN2C/ITPR2	-0.171814530911452
NA	NA	hsa04082	Neuroactive ligand signaling	15/753	199/9376	0.938557328475044	GNG7/GRIA4/ADCY3/ADRA2B/PRKCA/SLC1A3/P2RX4/HRH2/TAC3/P2RY6/GRIN2C/POMC/ADRB2/GABRA3/SLC1A2	-0.258881011102161
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/753	134/9376	0.929218449584746	PRKCH/GNA12/ADCY3/PRKCA/KCNMB4/MYH9/ACTA2/ITPR1/ITPR2/PRKCD	-0.243861601520948
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/753	27/9376	0.922335349958192	ABAT/OXCT1	-0.119419878527746
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/753	41/9376	0.911087357885531	GRIA4/GRIN2C/GABRA3	-0.168597921522321
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/753	69/9376	0.90228458148084	PTGER4/ITPR1/PDE1C/ADRB2/ITPR2	-0.240733604256222
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/753	69/9376	0.90228458148084	GRIA4/PRKCA/ATF6B/CAMK2G/GRIN2C	-0.240733604256222
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/753	56/9376	0.889394801745399	MAN1C1/MAN1B1/B4GALT1/ST6GAL1	-0.245310156264059
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/753	28/9376	0.889394801745399	GCH1/FPGS	-0.173200497682325
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/753	28/9376	0.889394801745399	SLC12A7/ATP6V1E2	-0.173200497682325
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/753	70/9376	0.889394801745399	GSTM4/GSTO2/PTGS2/GSTO1/GSTM2	-0.274471317948638
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/753	57/9376	0.873791384170919	ACSL5/ACSL1/ACSL3/ELOVL7	-0.282420169235159
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/753	43/9376	0.868711201704809	ACSL5/ACSL1/ACSL3	-0.254979462514071
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	24/753	323/9376	0.925190877357443	CD44/PDGFA/CCND1/VIM/DNMT3A/TGFB2/PLAU/PRKCA/PIM1/NFKB1/STAT3/MYC/CDKN2A/GRB2/RPTOR/BCL2/PTGS2/TPM1/CDKN1B/MDM2/ITGA5/DNMT1/PIK3R1/HDAC4	-0.404309080710631
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/753	29/9376	0.858726015478317	RASSF4/SAV1	-0.225153656923363
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/753	29/9376	0.858726015478317	CNGB1/GRK7	-0.225153656923363
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/753	44/9376	0.848967765302427	APTX/PARP1/TDG	-0.296730750330968
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/753	73/9376	0.852844330440794	GSTM4/GSTO2/ALDH3B1/GSTO1/GSTM2	-0.372975969854084
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/753	101/9376	0.862977134366823	EDNRB/ADCY3/PRKCA/WNT5A/LEF1/CAMK2G/POMC	-0.409119996447381
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/753	115/9376	0.866193198221606	GNG7/ALOX5/PRKCA/CYP4X1/APP/ITPR1/PTGS2/ITPR2	-0.426630698053824
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/753	15/9376	0.830101814962373	ST3GAL1	-0.194592984805041
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/753	15/9376	0.830101814962373	AK7	-0.194592984805041
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/753	88/9376	0.848967765302427	CD55/F13A1/SERPINA1/PLAU/F2R/ITGB2	-0.420633457947389
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/753	102/9376	0.854516574225972	ATP1B3/ADCY3/PRKCA/KCNQ1/ITPR1/ATP1B1/ITPR2	-0.436549999855839
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/753	31/9376	0.803324337060361	PFKP/FBP1	-0.324112477098304
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/753	31/9376	0.803324337060361	PGP/PCCA	-0.324112477098304
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/753	31/9376	0.803324337060361	SEC62/SRPRA	-0.324112477098304
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/753	89/9376	0.839428801647343	SLC12A5/GNG7/ADCY3/PRKCA/ABAT/GABRA3	-0.449757964082056
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/753	75/9376	0.830101814962373	PFKP/PSAT1/MTR/ASL/ENO3	-0.436524357946212
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/753	47/9376	0.794778333474612	ME2/PCK2/ACYP2	-0.416781588623785
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/753	32/9376	0.778220451527224	ABAT/PCCA	-0.371350490996562
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	12/753	174/9376	0.858726015478317	WFS1/MAN1C1/ERO1B/RRBP1/PPP1R15A/MAN1B1/PRKN/UBE2G2/BCL2/ATF6B/SEC62/SEC24A	-0.555839795770617
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/753	133/9376	0.842584549021957	SCN1A/MAPK13/GNG7/GRIA4/PRKCA/ITPR1/ATF6B/CAMK2G/ITPR2	-0.540282169535795
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/753	148/9376	0.841319407056459	CCND1/WNT5A/GADD45A/MYC/LEF1/DDB2/GRB2/SHC3/HES1/PIK3R1	-0.574982746029886
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/753	49/9376	0.762338401496057	NFKB1/ATF6B/GRIN2C	-0.492878641466688
NA	NA	hsa04519	Cadherin signaling	29/753	404/9376	0.893797746308495	NFKBIA/PRICKLE2/MAPK13/TAOK3/TMC6/VASP/VIM/PSENEN/ACTN1/MAP2K3/VAV2/WNT5A/FMN1/NFKB1/MYO1G/PCDH18/ABI2/SAV1/ANKRD6/LEF1/VAV3/CDH23/MYO1C/AFDN/MYO1F/LIMA1/MYO1A/GABRA3/ARPC5L	-0.644812898446727
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/753	79/9376	0.788071343318708	GSTM4/GSTO2/ALDH3B1/GSTO1/GSTM2	-0.558966459128088
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/753	18/9376	0.691751512468644	MTR	-0.386811715924547
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/753	19/9376	0.655343538128189	GALNS	-0.444374208333657
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/753	83/9376	0.750092001472024	JARID2/BCOR/YAF2/FBRSL1/SFMBT2	-0.675764179444484
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/753	83/9376	0.750092001472024	ACSL5/AMACR/ACSL1/ACSL3/PEX10	-0.675764179444484
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/753	37/9376	0.673055525645167	IL4I1/ALDH3B1	-0.588814653340879
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/753	20/9376	0.62257636122178	CYB5R3	-0.499290062084993
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/753	54/9376	0.691751512468644	ERCC1/EME2/HES1	-0.671269968802043
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/753	38/9376	0.655343538128189	HK2/CHIT1	-0.629079049812019
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/753	38/9376	0.655343538128189	NNMT/NT5E	-0.629079049812019
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/753	22/9376	0.565978510201618	ALDH3B1	-0.602251408317122
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/753	41/9376	0.607391571923687	BABAM2/RAD51B	-0.744471915035354
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/753	90/9376	0.691751512468644	ATP1B3/ADCY3/AQP9/SLC10A1/ATP1B1	-0.868284008713287
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/753	42/9376	0.592929867830266	IL4I1/KYNU	-0.781292973205842
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/753	44/9376	0.565978510201618	TAF7L/MNAT1	-0.8527154655794
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/753	154/9376	0.727686655973508	MTHFD1L/AK7/GCH1/PSAT1/NME4/KYNU/FPGS/DHRS3/PPCDC	-1.00686364058671
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/753	45/9376	0.553401209974915	ABCG1/ABCA1	-0.887388175709276
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/753	26/9376	0.478904893247523	PLB1	-0.78623395700089
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/753	26/9376	0.478904893247523	HES1	-0.78623395700089
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/753	63/9376	0.592929867830266	ALOX5/PLB1/PTGS2	-0.957962799971497
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/753	27/9376	0.461167674979096	ELOVL7	-0.828527402958493
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/753	143/9376	0.69658893563276	FCGR3A/FCGR2A/TNF/CD40/ACTN1/HLA-DQA2/HLA-DRA/FCGR1A	-1.0803934639658
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/753	65/9376	0.574685871897027	MOGAT1/DGKI/TKFC	-1.0167689085877
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/753	28/9376	0.4446974008727	ELOVL7	-0.869567507231846
NA	NA	hsa04081	Hormone signaling	13/753	219/9376	0.739131753048688	GNA12/GNG7/CGA/ADCY3/ADRA2B/GPER1/ITGAV/BMPR1A/STAT3/SLC16A10/POMC/ADRB2/PIK3R1	-1.15430507026416
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/753	30/9376	0.415050907481186	PCK2	-0.9482432149019
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/753	30/9376	0.415050907481186	PIGX	-0.9482432149019
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/753	30/9376	0.415050907481186	PLB1	-0.9482432149019
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/753	51/9376	0.488295185271984	PLD4/PLB1	-1.08276473946801
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/753	32/9376	0.389110225763612	BCL2	-1.02288159196658
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/753	34/9376	0.366221388953988	POLR2L	-1.09398417229678
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/753	110/9376	0.565978510201618	MAPK13/ADCY3/STK10/MAD1L1/PIK3R1	-1.35305472199991
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/753	37/9376	0.336527762822584	HK2	-1.19488844736043
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/753	63/9376	0.395286578553511	DOT1L/COLGALT2	-1.42307901417753
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/753	138/9376	0.541370748888504	MAPK13/ADCY3/MAD1L1/ITPR1/CAMK2G/ITPR2	-1.60385923013291
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/753	43/9376	0.28957040056827	ABCA1	-1.37974419576833
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/753	86/9376	0.434355600852404	TAS1R1/PDE1C/GABRA3	-1.55717991385533
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/753	44/9376	0.282989255100809	ADCY3	-1.40870018082783
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/753	68/9376	0.366221388953988	DHRS3/DHRS4L2	-1.54995032922905
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/753	46/9376	0.270685374444252	PSMD12	-1.4652338733091
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/753	191/9376	0.521529936102014	GNG7/GRB2/ATF6B/SHC3/GRIN2C/SLC29A3/HDAC4/SLC29A1	-1.97417572461069
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	19/753	370/9376	0.639402749362909	FPR1/EDNRB/FPR2/PTGER4/GRIA4/CGA/ADRA2B/LPAR6/P2RX4/HRH2/RXFP1/FPR3/TAC3/P2RY6/GRIN2C/F2R/POMC/ADRB2/GABRA3	-2.09127543029572
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/753	108/9376	0.345875756234322	EIF4A3/NUP210L/TNPO2	-2.02037992262983
NA	NA	hsa04382	Cornified envelope formation	6/753	217/9376	0.344281858740155	ITGA6/CLDN11/COL4A2/TCHH/COL4A1/S100A11	-2.88786554881864
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/753	103/9376	0.120888613829472	EIF4A3	-2.65097920330102
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/753	243/9376	0.256204263877276	EIF4A3/DDX46/PRPF6/DHX16/PRPF40B	-3.47139493626011
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/753	183/9376	0.13608226474793	GNL3L/GTPBP4	-3.48757244535052
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/753	449/9376	0.277316864686761	GNG7/ADCY3/OR5AU1/SLC8A1/PDE2A/SLC8A2/CNGB1/CAMK2G/PDE1C/OR2B11	-4.6373754270993