category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	58/115	238/9376	19.8687614176105	RPS26/RPL37A/RPS29/RPL41/RPS18/RPL27A/RPL28/RPS27/RPL36A/RPL37/RPL21/RPLP2/RPL23A/RPS8/RPS21/RPL27/RPL38/RPL35/RPS15/RPS12/RPL34/RPS23/RPL31/RPL35A/RPL36/RPL26/RPS25/RPS14/RPL32/UBA52/RPS16/RPS28/RPL30/RPS15A/RPS19/RPL29/RPS10/RPLP1/RPL13A/TRAF3/RPS11/RPL17/RPL39/RPL12/RPL13/RPS2/FAU/RPS27A/JAK1/RPL23/RPL10A/NFKB1/RPS20/RPS13/RPS17/PIK3CA/RPL22/F13A1	32.8557897786331
Genetic Information Processing	Translation	hsa03010	Ribosome	53/115	222/9376	19.464473168821	RPS26/RPL37A/RPS29/RPL41/RPS18/RPL27A/RPL28/RPS27/RPL36A/RPL37/RPL21/RPLP2/RPL23A/RPS8/RPS21/RPL27/RPL38/RPL35/RPS15/RPS12/RPL34/RPS23/RPL31/RPL35A/RPL36/RPL26/RPS25/RPS14/RPL32/UBA52/RPS16/RPS28/RPL30/RPS15A/RPS19/RPL29/RPS10/RPLP1/RPL13A/RPS11/RPL17/RPL39/RPL12/RPL13/RPS2/FAU/RPS27A/RPL23/RPL10A/RPS20/RPS13/RPS17/RPL22	31.0251271659257
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	10/115	138/9376	5.90800252047889	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCRB/UQCR11/MT-ND6/ATP5MF/UQCRQ	6.47233455109297
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/115	205/9376	4.37480381760339	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/NFKB1/UQCRB/UQCR11/MT-ND6/PIK3CA/UQCRQ	5.44405785387933
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/115	87/9376	6.55992003998001	ATP1B3/COX7C/COX6C/COX6B1/UQCRB/UQCR11/UQCRQ	5.80562936786477
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	11/115	227/9376	3.95081402030262	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/NFKB1/UQCRB/UQCR11/MT-ND6/PIK3CA/UQCRQ	5.01503039287777
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	12/115	268/9376	3.65061648280337	MT-ND3/UBA52/COX7C/ATP5F1E/RPS27A/COX6C/COX6B1/UQCRB/ITPR2/UQCR11/MT-ND6/UQCRQ	4.90578370808849
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	11/115	275/9376	3.26121739130435	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCRB/ITPR2/UQCR11/MT-ND6/PIK3CA/UQCRQ	4.2410141651374
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/115	235/9376	3.46938020351526	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCRB/UQCR11/MT-ND6/ATP5MF/UQCRQ	4.27199420718865
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	9/115	196/9376	3.74374445430346	UBA52/TRAF3/RPS27A/HLA-B/JAK1/NFKB1/ITPR2/PIK3CA/RB1	4.32569576277964
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/115	157/9376	4.15441705898643	COX7C/COX6C/COX6B1/NFKB1/UQCRB/UQCR11/PIK3CA/UQCRQ	4.44153048934508
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	12/115	388/9376	2.52155983863738	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/NFKB1/UQCRB/ITPR2/UQCR11/MT-ND6/PIK3CA/UQCRQ	3.41097851429196
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/115	93/9376	4.3833567087424	TRAF3/NFKB1/PIK3CA/BIRC2/RB1	3.65384990670295
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	13/115	480/9376	2.20811594202899	MT-ND3/UBA52/COX7C/ATP5F1E/RPS27A/COX6C/COX6B1/NFKB1/UQCRB/ITPR2/UQCR11/MT-ND6/UQCRQ	3.02787165958995
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/115	142/9376	3.44494794856093	CAMK4/JAK1/NFKB1/ITPR2/PIK3CA/RELB	3.2713308636459
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/115	105/9376	3.8824016563147	TRAF3/ERC1/NFKB1/RELB/BIRC2	3.30972167374973
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/115	106/9376	3.84577522559475	ZEB1/NFKB1/IGF1R/PIK3CA/RB1	3.28336584428763
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/115	156/9376	3.13578595317726	TRAF3/JAK1/NFKB1/PIK3CA/PPP2R2D/RB1	2.99750682632156
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/115	205/9376	2.78396606574761	TRAF3/HLA-B/JAK1/NFKB1/PIK3CA/RELB/RB1	2.87780119858477
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/115	205/9376	2.78396606574761	TRAF3/HLA-B/JAK1/NFKB1/HDAC4/PIK3CA/RB1	2.87780119858477
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/115	308/9376	2.38238283455675	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCRB/UQCR11/MT-ND6/UQCRQ	2.74886588331229
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/115	76/9376	4.29107551487414	CAMK4/IGF1R/PIK3CA/RB1	3.2100277410014
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/115	77/9376	4.23534726143422	JAK1/NFKB1/PIK3CA/RB1	3.17653581931147
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/115	180/9376	2.71768115942029	TRAF3/HLA-B/JAK1/NFKB1/PIK3CA/BIRC2	2.59289505581867
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/115	90/9376	3.62357487922705	CAMK4/NFKB1/IGF1R/PIK3CA	2.78680124063871
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/115	368/9376	1.99395085066163	MT-ND3/COX7C/ATP5F1E/COX6C/COX6B1/UQCRB/UQCR11/MT-ND6/UQCRQ	2.16760551142954
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/115	201/9376	2.43374432186892	ZEB1/NFKB1/IGF1R/KLF3/BIRC2/ETV6	2.28966697150918
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/115	105/9376	3.10592132505176	NFKB1/ITPR2/PIK3CA/RELB	2.41812706340416
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/115	157/9376	2.59651066186652	HLA-B/NFKB1/ITPR2/PIK3CA/RB1	2.24794332792604
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/115	109/9376	2.99194256082968	TRAF3/JAK1/NFKB1/PIK3CA	2.33091316511969
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/115	163/9376	2.50093358228861	TRAF3/JAK1/NFKB1/PIK3CA/RB1	2.15407270481825
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/115	30/9376	5.43536231884058	NFKB1/ABCC1	2.71133048959667
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	6/115	224/9376	2.18385093167702	HLA-B/JAK1/NFKB1/PIK3CA/RELB/RB1	1.99833658773732
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/115	119/9376	2.74051881622214	TRAF3/NFKB1/PIK3CA/BIRC2	2.12923054518281
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/115	227/9376	2.15498946561961	HLA-B/JAK1/NFKB1/ITPR2/PIK3CA/RB1	1.96295233575648
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/115	73/9376	3.35056581298392	IGF1R/PIK3CA/RB1	2.24661136364194
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/115	122/9376	2.67312900926586	NFKB1/PIK3CA/PAK2/PPP2R2D	2.07276569947903
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/115	125/9376	2.60897391304348	NFKB1/ABCC1/PIK3CA/PPP2R2D	2.01797269276983
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/115	77/9376	3.17651044607566	NFKB1/PIK3CA/RB1	2.13694631036301
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/115	80/9376	3.05739130434783	JAK1/IGF1R/PIK3CA	2.05929920667287
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/115	38/9376	4.29107551487414	ATP1B3/PIK3CA	2.26520925433231
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/115	187/9376	2.17995814926761	TRAF3/JAK1/NFKB1/ITPR2/BIRC2	1.8161800374297
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/115	136/9376	2.39795396419437	TRAF3/JAK1/NFKB1/PIK3CA	1.82991937238108
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/115	137/9376	2.38045065058712	NFKB1/ITPR2/PIK3CA/BIRC2	1.81373695580215
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/115	90/9376	2.71768115942029	JAK1/NFKB1/PIK3CA	1.82454711851201
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/115	144/9376	2.26473429951691	JAK1/IGF1R/PIK3CA/KAT6A	1.70426945818014
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/115	91/9376	2.68781653129479	NFKB1/IFITM1/PIK3CA	1.80285415299847
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/115	323/9376	1.76691344730112	ZEB1/NFKB1/HDAC4/FOXP1/ABCC1/SOX4/PIK3CA	1.56299277380876
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	7/115	333/9376	1.7138529834182	TRAF3/HLA-B/JAK1/NFKB1/PIK3CA/PPP2R2D/RB1	1.47801978122472
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/115	48/9376	3.39710144927536	ATP1B3/PIK3CA	1.85531809690012
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/115	98/9376	2.49582963620231	ATP1B3/CAMK4/ITPR2	1.65872199482129
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/115	99/9376	2.47061923583663	IGF1R/PIK3CA/RB1	1.63915369697924
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/115	214/9376	1.90491670052824	HLA-B/NFKB1/ITPR2/PIK3CA/PAK2	1.49219631294908
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/115	158/9376	2.06406164006604	TFDP2/SMC1B/STAG1/RB1	1.50308172597194
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/115	103/9376	2.37467285774588	NFKB1/PIK3CA/PPP2R2D	1.56319607730374
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/115	105/9376	2.32944099378882	UBA52/TOMM7/RPS27A	1.52653245305859
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/115	56/9376	2.91180124223602	MGAT5/MAN1C1	1.59894826856901
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/115	110/9376	2.22355731225296	NFKB1/IGF1R/PIK3CA	1.43840150149365
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/115	169/9376	1.92971443272447	UBA52/RPS27A/IGF1R/PIK3CA	1.35906262700317
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/115	112/9376	2.18385093167702	JAK1/NFKB1/BIRC2	1.40446970165285
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/115	173/9376	1.88509675797939	TRAF3/JAK1/NFKB1/PIK3CA	1.3093468471907
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/115	115/9376	2.1268809073724	CAMK4/ITPR2/PIK3CA	1.35488868251924
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/115	60/9376	2.71768115942029	IGF1R/ITPR2	1.48733587576913
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/115	238/9376	1.71282426013884	NFKB1/IGF1R/RALGAPA1/PIK3CA/PAK2	1.24122635937156
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/115	61/9376	2.67312900926586	ATP1B3/MT2A	1.46085978342554
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/115	62/9376	2.63001402524544	IGF1R/PIK3CA	1.43491007679521
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/115	120/9376	2.03826086956522	CAMK4/NFKB1/PIK3CA	1.2755311021273
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/115	122/9376	2.00484675694939	IGF1R/PIK3CA/PPP2R2D	1.24486030634981
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/115	184/9376	1.77240075614367	SSH2/ABLIM1/PIK3CA/PAK2	1.17910426478969
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/115	65/9376	2.50862876254181	ITPR2/PIK3CA	1.3600238195815
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/115	67/9376	2.43374432186892	CAMK4/ITPR2	1.31239090925492
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	5/115	253/9376	1.61127341467606	UBA52/RPS27A/NFKB1/ITPR2/PIK3CA	1.09832924447906
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/115	68/9376	2.39795396419437	NFKB1/PIK3CA	1.28921323492064
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/115	70/9376	2.32944099378882	PIK3CA/PAK2	1.2440624403899
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/115	71/9376	2.29663196570729	NFKB1/PIK3CA	1.22206224194043
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/115	72/9376	2.26473429951691	TRAF3/NFKB1	1.20042853510869
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/115	73/9376	2.23371054198928	PIK3CA/RB1	1.17914933832867
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/115	75/9376	2.17414492753623	PIK3CA/BIRC2	1.13760929540012
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/115	75/9376	2.17414492753623	ATP1B3/ITPR2	1.13760929540012
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/115	203/9376	1.60651103019919	IGF1R/PIK3CA/PAK2/BIRC2	0.973501537967354
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/115	76/9376	2.14553775743707	ATP1B3/ITPR2	1.11732713610437
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/115	138/9376	1.77240075614367	SMC1B/IGF1R/ITPR2	1.01858873959812
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/115	138/9376	1.77240075614367	FYB1/NFKB1/PIK3CA	1.01858873959812
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/115	140/9376	1.74708074534161	CAMK4/ITPR2/HDAC4	0.992419331528579
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/115	23/9376	3.54480151228733	ATP1B3	1.36159510457266
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/115	78/9376	2.09052396878484	JAK1/NFKB1	1.0776887819139
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/115	142/9376	1.72247397428047	UBA52/RPS27A/BIRC2	0.966667372872171
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	4/115	212/9376	1.5383100902379	FYB1/IGF1R/SIPA1L1/PIK3CA	0.883412473193005
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/115	148/9376	1.65264394829612	IGF1R/PIK3CA/RB1	0.891782604129493
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/115	26/9376	3.13578595317726	ABCC1	1.21519006635872
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/115	149/9376	1.64155237817333	MT-ND3/ITPR2/MT-ND6	0.879631168097112
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/115	86/9376	1.89605662285136	PIK3CA/PAK2	0.930213073656072
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/115	226/9376	1.44301654482493	ATP1B3/CAMK4/NFKB1/PIK3CA	0.751223619756067
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/115	29/9376	2.81139430284858	SLC24A1	1.08863299072842
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/115	93/9376	1.75334268349696	JAK1/NFKB1	0.813571057021021
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/115	93/9376	1.75334268349696	ATP1B3/ITPR2	0.813571057021021
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/115	31/9376	2.63001402524544	SEC62	1.01295033309187
NA	NA	hsa04981	Folate transport and metabolism	1/115	31/9376	2.63001402524544	ABCC1	1.01295033309187
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/115	94/9376	1.73469010175763	TRAF3/NFKB1	0.797724535533951
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/115	32/9376	2.54782608695652	BIRC2	0.977319023767324
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/115	98/9376	1.66388642413487	ITPR2/PIK3CA	0.736182107323106
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/115	99/9376	1.64707949055775	ITPR2/PIK3CA	0.721235458737743
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	3/115	170/9376	1.43877237851662	IGF1R/PIK3CA/RB1	0.643330100441536
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/115	101/9376	1.61446405510116	NFKB1/PIK3CA	0.691840252823644
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/115	102/9376	1.59863597612958	ATP1B3/ITPR2	0.677384054775284
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/115	103/9376	1.58311523849726	NFKB1/PIK3CA	0.663083909963576
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/115	39/9376	2.09052396878484	MTHFD1L	0.760447884087987
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/115	39/9376	2.09052396878484	HLA-B	0.760447884087987
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/115	181/9376	1.35133317319241	JAK1/NFKB1/MRC2	0.531848814005519
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/115	109/9376	1.49597128041484	JAK1/NFKB1	0.580371146123157
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/115	109/9376	1.49597128041484	NFKB1/PIK3CA	0.580371146123157
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/115	110/9376	1.48237154150198	IGF1R/PIK3CA	0.5670710661658
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/115	41/9376	1.98854718981972	RB1	0.706867133795254
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/115	44/9376	1.85296442687747	MAN1C1	0.631939509331449
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/115	44/9376	1.85296442687747	TDG	0.631939509331449
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/115	44/9376	1.85296442687747	HLA-B	0.631939509331449
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/115	193/9376	1.26731245776076	NFKB1/PIK3CA/CCR7	0.418129854773709
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/115	45/9376	1.81178743961353	ABCC1	0.608261188033367
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/115	45/9376	1.81178743961353	HLA-B	0.608261188033367
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/115	195/9376	1.2543143812709	NFKB1/HDAC4/PIK3CA	0.399897646429358
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/115	47/9376	1.73469010175763	PIK3CA	0.562653710820883
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/115	122/9376	1.33656450463293	ATP1B3/PIK3CA	0.416954913220584
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/115	122/9376	1.33656450463293	ITPR2/PIK3CA	0.416954913220584
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/115	49/9376	1.66388642413487	NFKB1	0.519190163420428
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	5/115	362/9376	1.12611097766034	JAK1/NFKB1/IGF1R/PIK3CA/PPP2R2D	0.272680459517338
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	3/115	204/9376	1.19897698209719	IGF1R/ITPR2/PIK3CA	0.320178021447456
Organismal Systems	Immune system	hsa04611	Platelet activation	2/115	126/9376	1.29413388543823	ITPR2/PIK3CA	0.370394971777178
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/115	52/9376	1.56789297658863	IGF1R	0.457585920611311
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/115	130/9376	1.2543143812709	NFKB1/PIK3CA	0.32536532540013
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/115	53/9376	1.5383100902379	ATP1B3	0.437923478140428
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/115	54/9376	1.50982286634461	HLA-B	0.418665579795648
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/115	133/9376	1.22602157567833	IGF1R/PIK3CA	0.292532995609684
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/115	133/9376	1.22602157567833	HLA-B/PIK3CA	0.292532995609684
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/115	133/9376	1.22602157567833	ITPR2/PPP2R2D	0.292532995609684
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/115	216/9376	1.13236714975845	TRAF3/NFKB1/PIK3CA	0.219313301323535
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/115	217/9376	1.12714886796233	NFKB1/PIK3CA/RB1	0.211165979669358
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/115	56/9376	1.45590062111801	NFKB1	0.381295655987541
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/115	300/9376	1.08707246376812	NFKB1/IGF1R/PAK2/RELB	0.170804706439418
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/115	139/9376	1.17309978104473	ITPR2/PIK3CA	0.229110009391576
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/115	59/9376	1.38187177597642	PIK3CA	0.327877137860721
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/115	59/9376	1.38187177597642	PIK3CA	0.327877137860721
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	2/115	142/9376	1.14831598285364	NFKB1/PIK3CA	0.198446209280929
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/115	60/9376	1.35884057971014	PIK3CA	0.310719172156967
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/115	144/9376	1.13236714975845	TRAF3/NFKB1	0.178368919610909
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/115	144/9376	1.13236714975845	ITPR2/PIK3CA	0.178368919610909
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	3/115	232/9376	1.05427286356822	SSH2/PIK3CA/PAK2	0.093274780701652
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/115	150/9376	1.08707246376812	PIK3CA/RB1	0.119791320944612
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/115	65/9376	1.2543143812709	LCLAT1	0.229263570189274
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/115	65/9376	1.2543143812709	ITPR2	0.229263570189274
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/115	66/9376	1.23530961791831	NFKB1	0.213767866207927
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/115	154/9376	1.05883681535855	ATP1B3/PPP2R2D	0.0820356409330177
NA	NA	hsa04518	Integrin signaling	2/115	154/9376	1.05883681535855	IGF1R/PIK3CA	0.0820356409330177
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/115	154/9376	1.05883681535855	CAMK4/ITPR2	0.0820356409330177
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	2/115	155/9376	1.05200561009818	HLA-B/MRC2	0.0727499417578096
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/115	155/9376	1.05200561009818	ITPR2/RB1	0.0727499417578096
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/115	69/9376	1.18160050409578	PIK3CA	0.168710593965662
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/115	69/9376	1.18160050409578	ITPR2	0.168710593965662
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/115	69/9376	1.18160050409578	CAMK4	0.168710593965662
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/115	157/9376	1.03860426474661	PPP2R2D/BIRC2	0.054356166507006
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/115	70/9376	1.16472049689441	NFKB1	0.154141917020838
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/115	70/9376	1.16472049689441	HLA-B	0.154141917020838
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/115	158/9376	1.03203082003302	IGF1R/PIK3CA	0.045246382772094
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/115	71/9376	1.14831598285364	NFKB1	0.139786282704247
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/115	71/9376	1.14831598285364	PIK3CA	0.139786282704247
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	3/115	248/9376	0.986255259467041	NFKB1/PIK3CA/BIRC2	-0.0244444453135802
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/115	73/9376	1.11685527099464	SERINC5	0.111687313015393
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/115	250/9376	0.978365217391304	HLA-B/IGF1R/RAB11FIP3	-0.0386356233928671
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/115	166/9376	0.982294394971189	ATP1B3/ITPR2	-0.0256472388927242
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/115	168/9376	0.970600414078675	JAK1/BIRC2	-0.0428468417461446
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/115	168/9376	0.970600414078675	JAK1/PIK3CA	-0.0428468417461446
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/115	78/9376	1.04526198439242	PIK3CA	0.0447292624674956
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/115	78/9376	1.04526198439242	PIK3CA	0.0447292624674956
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/115	78/9376	1.04526198439242	NFKB1	0.0447292624674956
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/115	174/9376	0.937131434282859	SEC62/MAN1C1	-0.0932765937870201
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/115	82/9376	0.994273594909862	HLA-B	-0.00580354392057722
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/115	83/9376	0.982294394971189	NFKB1	-0.0180541674336596
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/115	85/9376	0.959181585677749	ADK	-0.0421250062886818
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/115	86/9376	0.948028311425682	ATP1B3	-0.05395277813803
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/115	87/9376	0.937131434282859	PIK3CA	-0.0656469137718543
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/115	88/9376	0.926482213438735	F13A1	-0.0772108390625445
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/115	89/9376	0.916072300928188	ITPR2	-0.0886478513578922
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/115	90/9376	0.905893719806763	ATP1B3	-0.0999611257414048
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/115	191/9376	0.853721830184384	CAMK4/HDAC4	-0.227594748793819
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/115	93/9376	0.876671341748481	IGF1R	-0.133188559539621
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/115	93/9376	0.876671341748481	ITPR2	-0.133188559539621
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/115	98/9376	0.831943212067436	PIK3CA	-0.186357780175082
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/115	99/9376	0.823539745278876	PIK3CA	-0.19668277950375
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	2/115	200/9376	0.815304347826087	NFKB1/PAK2	-0.294205362052892
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/115	100/9376	0.815304347826087	CCR7	-0.206910208504025
NA	NA	hsa04517	IgSF CAM signaling	3/115	299/9376	0.818031118220154	ERC1/PIK3CA/PAK2	-0.356342127861645
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/115	103/9376	0.791557619248628	PPP2R2D	-0.237028257376584
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/115	103/9376	0.791557619248628	ATP1B3	-0.237028257376584
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/115	104/9376	0.783946488294314	LCLAT1	-0.24688625054792
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/115	107/9376	0.761966680211296	ITPR2	-0.275942641728005
NA	NA	hsa04081	Hormone signaling	2/115	219/9376	0.744570180663093	IGF1R/PIK3CA	-0.426209045730292
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/115	115/9376	0.708960302457467	ITPR2	-0.349927299135513
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/115	115/9376	0.708960302457467	ITPR2	-0.349927299135513
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/115	116/9376	0.702848575712144	PIK3CA	-0.358845028467395
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/115	116/9376	0.702848575712144	ITPR2	-0.358845028467395
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/115	128/9376	0.63695652173913	ADK	-0.460834866393312
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/115	134/9376	0.608436080467229	ITPR2	-0.508718698036593
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/115	250/9376	0.652243478260869	BORCS7/GPR155	-0.621027271192741
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/115	138/9376	0.590800252047889	PIK3CA	-0.539624349400408
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/115	254/9376	0.641971927422116	CAMK4/ITPR2	-0.644606263516021
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/115	149/9376	0.547184126057776	PIK3CA	-0.620854928887973
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/115	154/9376	0.529418407679277	MTHFD1L	-0.656127669420125
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/115	160/9376	0.509565217391304	HLA-B	-0.697229314140585
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/115	170/9376	0.479590792838875	PPP2R2D	-0.763026397982302
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/115	178/9376	0.458036150464094	TBL1X	-0.813465677853223
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/115	194/9376	0.42025997310623	BICDL1	-0.909224486655544
NA	NA	hsa04382	Cornified envelope formation	1/115	217/9376	0.375716289320777	PPP2R2D	-1.03679634329307
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/115	233/9376	0.349916029109909	ATP1B3	-1.11971803849095
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/115	243/9376	0.335516192521023	DDX46	-1.16946283995585
NA	NA	hsa04519	Cadherin signaling	2/115	404/9376	0.403616013775291	NFKB1/IGF1R	-1.3654557790843
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/115	298/9376	0.273592063028888	CCR7	-1.42003562517881