category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	67/650	238/9376	4.06071105365223	RPS26/RPL37A/RPS18/RPL21/RPL27A/RPL36A/RPL37/RPLP2/RPL41/RPL38/RPS29/RPL31/RPL27/RPL35A/RPS23/RPL34/RPL23A/RPS8/RPS21/RPL36/UBA52/RPL35/RPL26/RPL28/RPS27/RPS15/RPLP1/FAU/RPS19/RPS10/MAPK13/RPS12/RPL32/RPS25/RPL30/TRAF3/HBEGF/RPS27A/F13A1/RPL29/NFKBIA/RPS20/RPL17/TLR7/FCGR2A/RPS14/IKBKE/MX2/RPL13A/RPL12/RPS15A/RPL22/IL6/STAT3/TLR2/TYK2/RPL23/JAK1/TNF/IL6R/MMP1/RPS16/RPS11/C3/RPL36AL/NFKB1/MAP3K7	13.053288772558
Genetic Information Processing	Translation	hsa03010	Ribosome	51/650	222/9376	3.31376299376299	RPS26/RPL37A/RPS18/RPL21/RPL27A/RPL36A/RPL37/RPLP2/RPL41/RPL38/RPS29/RPL31/RPL27/RPL35A/RPS23/RPL34/RPL23A/RPS8/RPS21/RPL36/UBA52/RPL35/RPL26/RPL28/RPS27/RPS15/RPLP1/MRPL23/FAU/RPS19/RPS10/RPS12/RPL32/RPS25/RPL30/RPS27A/RPL29/RPS20/RPL17/RPS14/RPL13A/MRPL52/RPL12/RPS15A/RPL22/RPL23/MRPL41/RPS16/RPS11/RPL36AL/MRPL53	9.52192192333004
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	37/650	138/9376	3.86746934225195	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UQCR11/ATP5F1E/NDUFA1/COX8A/COX6B1/ATP5MF/MT-ND2/UQCRB/NDUFA2/COX7A2/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/MT-ND6/NDUFC1/NDUFB2/NDUFA3/COX17/COX6A1/UQCR10/NDUFB3/NDUFA4/NDUFS6/ATP5MG/NDUFA7	9.26155819050219
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	50/650	235/9376	3.06906710310966	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UQCR11/ATP5F1E/NDUFA1/COX8A/MAPK13/COX6B1/ATP5MF/MT-ND2/UQCRB/NDUFA2/COX7A2/ACSL5/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/MT-ND6/NDUFC1/NDUFB2/SMARCA4/NDUFA3/COX17/GRB2/PRKAG2/COX6A1/UQCR10/ACSL3/NDUFB3/NDUFA4/ADCY3/SMARCE1/NDUFAF2/MAP2K3/NDUFS6/COX14/ACSL1/ATP5MG/NDUFAF8/NDUFA7	8.76690629466408
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	46/650	205/9376	3.23674296435272	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UQCR11/ATP5F1E/NDUFA1/COX8A/MAPK13/TGFB1/COX6B1/MT-ND2/UQCRB/NDUFA2/COX7A2/UQCRQ/TGFB2/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/CYBA/MT-ND6/NDUFC1/NDUFB2/NDUFA3/COL1A1/COX6A1/UQCR10/NDUFB3/MMP2/NDUFA4/SLC25A6/PARP1/NDUFS6/PTPA/PRKCD/NFKB1/NDUFA7/CAMK2G	8.83729547656649
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/650	227/9376	2.79596069129109	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UQCR11/ATP5F1E/NDUFA1/COX8A/MAPK13/COX6B1/MT-ND2/HIF1A/UQCRB/NDUFA2/COX7A2/NFKBIA/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/CYBA/MT-ND6/NDUFC1/NDUFB2/NDUFA3/GRB2/COX6A1/UQCR10/GSTM4/NDUFB3/NDUFA4/SLC25A6/GSTO2/NDUFS6/PRKCD/NFKB1/NDUFA7	7.47579965083003
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/650	157/9376	3.215678588927	MT-CYB/COX7C/COX6C/UQCR11/NDUFA1/COX8A/MAPK13/TGFB1/COX6B1/UQCRB/NDUFA2/COX7A2/UQCRQ/NDUFB4/NDUFA13/NDUFB7/COX7B/NDUFC1/NDUFB2/IL1A/NDUFA3/PRKAG2/COX6A1/UQCR10/IL6/SREBF1/NDUFB3/TNF/NDUFA4/IL6R/NDUFS6/NR1H3/SOCS3/NFKB1/NDUFA7	7.64098578698477
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	47/650	275/9376	2.4652979020979	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UQCR11/ATP5F1E/NDUFA1/COX8A/MAPK13/COX6B1/MT-ND2/UQCRB/NDUFA2/COX7A2/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/CYBA/MT-ND6/NDUFC1/NDUFB2/IL1A/NDUFA3/COX6A1/UQCR10/IL6/NDUFB3/TNF/NDUFA4/ATF6B/SLC25A6/EGR1/ITPR1/NDUFS6/NOTCH1/PRKCD/GRIN2C/TUBB8/NDUFA7	6.73104400390368
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	43/650	268/9376	2.3143972445465	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UBA52/UQCR11/ATP5F1E/NDUFA1/COX8A/COX6B1/MT-ND2/UQCRB/RPS27A/NDUFA2/COX7A2/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/MT-ND6/NDUFC1/NDUFB2/NDUFA3/COX6A1/UQCR10/SLC39A11/NDUFB3/UBE2G2/NDUFA4/SLC25A6/ITPR1/NDUFS6/SLC39A8/TUBB8/NDUFA7/CAMK2G	5.95822964823837
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/650	87/9376	3.31600353669319	ATP1B3/MT-CYB/TPM4/COX7C/COX6C/UQCR11/COX8A/COX6B1/UQCRB/COX7A2/UQCRQ/CACNA2D4/COX7B/TPM3/COX6A1/UQCR10/SLC8A1/SLC8A2/SLC9A7/TPM1	5.92310014183828
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	44/650	308/9376	2.06065934065934	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UQCR11/ATP5F1E/NDUFA1/COX8A/HIP1/GRIA4/COX6B1/MT-ND2/DNAH17/UQCRB/POLR2L/NDUFA2/COX7A2/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/MT-ND6/NDUFC1/NDUFB2/NRBF2/NDUFA3/COX6A1/UQCR10/NDUFB3/NDUFA4/SLC25A6/ITPR1/NDUFS6/WIPI1/ACTR1B/TUBB8/NDUFA7	5.16571254728004
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	33/650	205/9376	2.32201125703565	HLA-B/CD44/HLA-E/CCND1/MAPK13/NCOR2/TRAF3/HLA-F/NFKBIA/JAK3/CD40/IKBKE/HLA-DQA2/RBPJ/IL6/ENTPD1/STAT3/TLR2/TYK2/BCL2/JAK1/TNF/VIM/MAP2K3/HLA-DQB2/DDB2/ITGAL/HES1/RELB/NFKB1/MAP3K7/TNFAIP3/MYC	5.22322157170705
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/650	78/9376	3.3287573964497	FCGR3A/MAPK13/TGFB1/NFKBIA/TGFB2/FCGR2A/ITGA4/CYBA/IL1A/HLA-DQA2/TLR2/JAK1/TNF/HLA-DQB2/ITGB2/C3/NFKB1/MAP3K7	5.63652567890378
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	60/650	480/9376	1.80307692307692	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UBA52/UQCR11/ATP5F1E/NDUFA1/COX8A/HIP1/MAPK13/GRIA4/COX6B1/MT-ND2/DNAH17/UQCRB/RPS27A/NDUFA2/COX7A2/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/MT-ND6/NDUFC1/NDUFB2/WNT5A/TNFRSF1B/NRBF2/IL1A/NDUFA3/COX6A1/UQCR10/IL6/BCL2/NDUFB3/TNF/UBE2G2/NDUFA4/ATXN1/SLC25A6/MAP2K3/APP/TOMM40L/ITPR1/NDUFS6/WIPI1/ACTR1B/GRIN2C/NFKB1/TUBB8/NDUFA7/CAMK2G	4.92963869682591
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/650	149/9376	2.51704697986577	MT-ND3/MT-ND5/MT-ND4/MT-ND1/MT-ND4L/NDUFA1/MAPK13/GRIA4/MT-ND2/NDUFA2/NDUFB4/NDUFA13/GNG7/NDUFB7/MT-ND6/NDUFC1/NDUFB2/NDUFA3/NDUFB3/NDUFA4/ADCY3/ITPR1/NDUFS6/GABRA3/GNB1/NDUFA7	5.09444193113019
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	34/650	224/9376	2.18945054945055	HLA-B/HLA-E/CCND1/TGFB1/HLA-F/NFKBIA/JAK3/ETS2/TGFB2/FOSL1/CD40/TLN1/CDKN2C/HLA-DQA2/TLN2/MAD1L1/IL6/CDKN2B/CDKN2A/JAK1/TNF/NFATC1/ADCY3/ATF6B/SLC25A6/HLA-DQB2/EGR1/ITGB2/ETS1/ITGAL/MAP3K1/RELB/NFKB1/MYC	4.91753100594189
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	48/650	368/9376	1.88147157190635	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UQCR11/ATP5F1E/NDUFA1/COX8A/MAPK13/COX6B1/MT-ND2/DNAH17/UQCRB/NDUFA2/COX7A2/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/MT-ND6/NDUFC1/NDUFB2/TNFRSF1B/NRBF2/NDUFA3/COX6A1/UQCR10/BCL2/NDUFB3/TNF/NDUFA4/NUP210L/MAP2K3/TOMM40L/NDUFS6/WIPI1/ERBB4/ACTR1B/GRIN2C/TUBB8/NDUFA7	4.70817658708682
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	49/650	388/9376	1.82166534496431	MT-ND3/MT-ND5/MT-CYB/MT-ATP8/MT-ND4/COX7C/MT-ND1/COX6C/MT-ND4L/UQCR11/ATP5F1E/NDUFA1/COX8A/COX6B1/MT-ND2/PSENEN/UQCRB/NDUFA2/COX7A2/UQCRQ/NDUFB4/MT-ATP6/NDUFA13/NDUFB7/COX7B/MT-ND6/NDUFC1/NDUFB2/WNT5A/NRBF2/IL1A/NDUFA3/COX6A1/UQCR10/IL6/SLC39A11/NDUFB3/TNF/NDUFA4/SLC25A6/APP/ITPR1/NDUFS6/WIPI1/SLC39A8/GRIN2C/NFKB1/TUBB8/NDUFA7	4.51142782105067
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	24/650	142/9376	2.43796316359697	FCGR3A/MAPK13/TGFB1/LCP2/NFKBIA/TGFB2/FOSL1/FCGR2A/CYBA/IL1A/GRB2/LILRB3/TYK2/JAK1/TNF/NFATC1/LILRB1/ITPR1/TREM2/RELB/SOCS3/OSCAR/NFKB1/MAP3K7	4.71228675040362
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/650	99/9376	2.76836052836053	TPM4/DMD/ITGA6/TGFB1/SSPN/TGFB2/ITGA4/CACNA2D4/ITGAV/TPM3/ITGA9/PRKAG2/ITGA5/IL6/SLC8A1/SLC8A2/TNF/SNTB1/TPM1	4.82746733302291
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/650	112/9376	2.57582417582418	ITGA6/MAPK13/TGFB1/NFKBIA/TGFB2/CD40/ALOX5/HLA-DQA2/STAT3/TLR2/TYK2/BCL2/JAK1/TNF/CIITA/MAP2K3/HLA-DQB2/CCR5/NFKB1/MAP3K7	4.57880564268772
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	32/650	233/9376	1.98106305711456	ATP1B3/TPM4/DMD/ITGA6/FMNL3/ACTN2/SDC3/ANK2/SSPN/TLN1/ITGA4/COL4A2/ITGAV/MYH9/TPM3/ITGA9/AMPD3/COL1A1/NID1/ITGA5/TLN2/FMN2/ENO3/VIM/PDLIM2/FMNL1/CAPZB/COL4A1/SDC2/SNTB1/NEB/TPM1	4.13871227449468
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/650	101/9376	2.57072353389185	CCND1/MAPK13/TGFB1/TGFB2/COL4A2/IL1A/PIM1/COL1A1/IL6/STAT3/BCL2/TNF/MMP2/NFATC1/COL4A1/EGR1/PRKCD/NFKB1	4.33149872295018
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/650	157/9376	2.2050367466928	TIMD4/DUSP4/MAPK13/DUSP2/TGFB1/CH25H/PTGER4/HIF1A/GPR132/DNMT3A/ALOX5/SCARF1/ITGAV/CX3CR1/CD24/PANX1/NFATC1/PPARD/SPHK1/NR1H3/ATP11A/RAB7B/P2RY6/CAMK2G	4.15568787832765
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/650	105/9376	2.47279120879121	TPM4/DMD/ITGA6/TGFB1/SSPN/TGFB2/ITGA4/CACNA2D4/ITGAV/TPM3/ITGA9/ITGA5/SLC8A1/SLC8A2/TNF/ADCY3/SNTB1/TPM1	4.1419729122313
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	24/650	163/9376	2.12386974988202	MAPK13/TGFB1/TRAF3/NFKBIA/JAK3/TGFB2/IKBKE/GRB2/IL6/STAT3/TLR2/TYK2/BCL2/JAK1/TNF/SLC10A1/NFATC1/ATF6B/MAP2K3/DDB2/MAP3K1/NFKB1/MAP3K7/MYC	3.95042627076649
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	18/650	109/9376	2.38204657727594	MAPK13/TGFB1/HIF1A/NFKBIA/JAK3/HLA-DQA2/IL6/STAT3/TYK2/JAK1/IL6R/NFATC1/IL4R/RUNX1/IL21R/HLA-DQB2/NFKB1/IL27RA	3.96096549701193
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/650	50/9376	3.17341538461538	TGFB1/HBA2/TGFB2/CD40/IL6/TLR2/TNF/HBA1/ITGB2/SDC2/ITGAL	4.20547199923137
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/650	66/9376	2.84121212121212	TGFB1/TGFB2/IL1A/HLA-DQA2/IL6/STAT3/TLR2/TNF/NFATC1/IL4R/IL21R/HLA-DQB2/NFKB1	4.09671417701492
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/650	94/9376	2.45525368248772	MAPK13/TRAF3/CXCL1/NFKBIA/FOSL1/IKBKE/MAPK6/IL6/IL17D/TNF/MMP1/IL17RA/IL17B/NFKB1/MAP3K7/TNFAIP3	3.87004989184393
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	25/650	181/9376	1.99235019124522	FCGR3A/FCER1G/MAPK13/TGFB1/RIPK2/TGFB2/PLK3/CORO1A/FCGR2A/IL1A/HLA-DQA2/IL6/CARD9/TLR2/IRAK2/BCL2/JAK1/TNF/CIITA/HLA-DQB2/ITGB2/SPHK1/C3/NFKB1/CAMK2G	3.67928212532627
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/650	204/9376	1.90914027149321	TWIST1/CD44/CCND1/MAPK13/TGFB1/HIF1A/HBEGF/ANK2/TIAM1/TGFB2/ITGAV/WNT5A/VAV2/GRB2/COL1A1/ITGA5/STAT3/TLR2/PLAU/TNF/MMP2/ITPR1/SDC2/ERBB4/VAV1/MYC/CAMK2G	3.58301534959361
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/650	70/9376	2.67885714285714	HLA-B/HLA-E/CCND1/CD55/DMD/HLA-F/SSPN/CD40/HLA-DQA2/HLA-DQB2/ITGB2/ITGAL/SNTB1	3.84783066039406
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/650	196/9376	1.9134693877551	HLA-B/HLA-E/CCND1/UBA52/MAPK13/HIF1A/PREX1/TRAF3/HLA-F/CXCL1/RPS27A/NFKBIA/IKBKE/GNG7/HCK/IL6/STAT3/TYK2/JAK1/NFATC1/CCR5/ITPR1/C3/NFKB1/MYC/GNB1	3.52724320176948
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	18/650	119/9376	2.18187459599224	MAP3K8/MAPK13/TRAF3/CXCL1/NFKBIA/CFLAR/TNFRSF1B/RHBDF2/IL6/TNF/ATF6B/IRF1/MAP2K3/MMP14/SOCS3/NFKB1/MAP3K7/TNFAIP3	3.54115110303726
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	24/650	180/9376	1.92328205128205	HLA-B/HLA-E/TRAF3/HLA-F/NFKBIA/IKBKE/POU2F2/EIF2B3/HLA-DQA2/NECTIN2/ITGA5/IL6/CARD9/TLR2/TYK2/BCL2/JAK1/TNF/HLA-DQB2/C3/SOCS3/NFKB1/MAP3K7/POU2F3	3.41354691720979
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/650	105/9376	2.19803663003663	FCER1G/MAPK13/NFKBIA/PLK3/IKBKE/IL6/CARD9/IL17D/TNF/CBLB/NFATC1/IRF1/ITPR1/RELB/PRKCD/NFKB1	3.36927273862894
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	24/650	187/9376	1.85128753599342	MAPK13/TRAF3/CXCL1/RIPK2/NFKBIA/CASP5/IKBKE/CYBA/ANTXR1/CARD16/IL6/CARD9/TYK2/BCL2/PANX1/JAK1/TNF/CARD18/ITPR1/PRKCD/NFKB1/MAP3K7/TNFAIP3/CASP4	3.20920650973316
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	26/650	212/9376	1.76905660377358	FPR1/PDGFA/MAGI1/DOCK4/RALGDS/VASP/MAPK13/RASGRP3/LCP2/RAPGEF1/TIAM1/SIPA1L1/TLN1/VAV2/SIPA1/TLN2/RASSF5/ADCY3/MAP2K3/ITGB2/SIPA1L2/FGF18/ITGAL/APBB1IP/F2R/VAV1	3.09113810038466
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/650	45/9376	2.88492307692308	HLA-B/HLA-E/HLA-F/IL1A/HLA-DQA2/IL6/TNF/HLA-DQB2/KLRD1	3.45915884924425
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/650	54/9376	2.67122507122507	SMS/DNMT3A/PSAT1/APIP/IL4I1/LDHC/MTR/SDS/DNMT1/KYAT3	3.36133645015829
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/650	130/9376	1.99725443786982	EDNRB/MAPK13/TGFB1/NFKBIA/GNG7/COL4A2/GRB2/ACTA2/COL1A1/RXFP1/SHC3/MMP2/ADCY3/MMP1/ATF6B/COL4A1/NFKB1/GNB1	3.12489494454342
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/650	157/9376	1.837530622244	HLA-B/HLA-E/CCND1/MAPK13/TGFB1/HLA-F/TGFB2/IL1A/IL6/RASSF5/CDKN2B/CDKN2A/NFATC1/SLC25A6/MAP2K3/ZFP36L1/ITPR1/ETS1/NFKB1/MYC	2.88830682063415
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/650	136/9376	1.90914027149321	CCND1/TRAF3/NFKBIA/JAK3/TLR7/IKBKE/MX2/IL1A/IL6/STAT3/TLR2/TYK2/BCL2/JAK1/CBLB/NFKB1/MAP3K7/TNFAIP3	2.91473500395692
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/650	128/9376	1.91576923076923	NME4/PDE4B/AK7/PAPSS2/ENPP4/PDE4A/ADA2/PDE2A/AMPD3/ENTPD1/NUDT16/ADCY3/ADK/PDE8A/RRM1/NT5E/PDE9A	2.84709418233202
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/650	98/9376	2.06065934065934	FCGR3A/LIMK2/VASP/GSN/FCGR2A/DNM2/VAV2/HCK/ASAP1/WAS/LIMK1/SPHK1/VAV1/PRKCD	2.88068974694899
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	26/650	227/9376	1.65215859030837	HLA-B/HLA-E/CCND1/GNA12/MAPK13/PTGER4/HLA-F/NFKBIA/GNG7/ITGAV/GRB2/IL6/STAT3/CDKN2A/JAK1/TNF/IL6R/NFATC1/ADCY3/ATF6B/CCR5/ITPR1/AKAP13/NFKB1/MYC/GNB1	2.71465126455984
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	25/650	216/9376	1.66951566951567	MAPK13/OLR1/ABCG1/TRAF3/CXCL1/NFKBIA/CD40/IKBKE/CYBA/POU2F2/VAV2/IL6/STAT3/TLR2/BCL2/TNF/NFATC1/MMP1/MAP2K3/ITPR1/VAV1/NFKB1/MAP3K7/POU2F3/CAMK2G	2.71690589905309
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/650	109/9376	1.98503881439661	MAP3K8/MAPK13/TRAF3/NFKBIA/TLR7/CD40/IKBKE/IL6/TLR2/TYK2/JAK1/TNF/MAP2K3/NFKB1/MAP3K7	2.82313550150598
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/650	70/9376	2.26672527472527	PCK2/NFKBIA/ACSL5/TNFRSF1B/PRKAG2/ACSL3/STAT3/TNF/ACSL1/SOCS3/NFKB1	2.90325139999047
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/650	100/9376	2.01944615384615	CD44/CD55/ITGA6/ITGA4/IL1A/HLA-DQA2/ITGA5/IL6/CD24/CD5/TNF/IL6R/IL4R/HLA-DQB2	2.797168532744
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/650	35/9376	2.88492307692308	PFKP/PFKFB3/HK2/PFKFB4/TKFC/FBP1/ENOSF1	3.04905795866706
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/650	44/9376	2.62265734265734	HLA-B/HLA-E/HLA-F/IL1A/HLA-DQA2/ICA1/TNF/HLA-DQB2	2.94442505561497
NA	NA	hsa04518	Integrin signaling	19/650	154/9376	1.77966033966034	PDGFA/CCND1/ITGA6/TGFB1/TLN1/ACTN1/ITGA4/COL4A2/ITGAV/ITGA9/COL1A1/ITGA5/TLN2/LIMS1/COL4A1/ITGB2/PARVB/ITGAL/C3	2.66248982313716
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/650	103/9376	1.96062733383122	TGFB1/SERPINB9/CXCL1/TGFB2/ACTN1/COL4A2/COL1A1/IL6/TLR2/TNF/COL4A1/ITGB2/NFKB1/RAB7B	2.67545798098203
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/650	93/9376	2.01634408602151	CGA/MAPK13/HBEGF/GRB2/MMP2/ADCY3/MAP2K3/EGR1/ITPR1/MAP3K1/MMP14/PRKCD/CAMK2G	2.68826931991996
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/650	21/9376	3.43443223443223	CHST7/CSGALNACT2/DSE/XYLT1/CHST15	3.04803643125826
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/650	105/9376	1.92328205128205	TRAF3/PPP1R13L/CXCL1/NFKBIA/CFLAR/CD40/PLAU/BCL2/TNF/PARP1/RELB/NFKB1/MAP3K7/TNFAIP3	2.59657256502659
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/650	193/9376	1.64425667596652	PREX1/CXCL1/TIAM1/NFKBIA/JAK3/GNG7/GRK7/VAV2/GRB2/HCK/CX3CR1/STAT3/WAS/SHC3/CCL14/ADCY3/CCR5/GRK5/VAV1/PRKCD/NFKB1/GNB1	2.4681980341109
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/650	160/9376	1.71292307692308	HLA-B/HLA-E/ITGA6/CLDN11/SDC3/HLA-F/ALCAM/CD276/CD40/ITGA4/ITGAV/ITGA9/HLA-DQA2/NECTIN2/NEGR1/HLA-DQB2/ITGB2/SDC2/ITGAL	2.48236788075196
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/650	86/9376	2.01273703041145	DMD/ITGA6/ACTN2/SSPN/ITGA4/CACNA2D4/ITGAV/ITGA9/ITGA5/SLC8A1/SLC8A2/SNTB1	2.57497354159899
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/650	30/9376	2.88492307692308	FOLR3/IL6/MTR/FPGS/TNF/NFKB1	2.82212393892692
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/650	39/9376	2.58903353057199	HLA-B/HLA-E/HLA-F/CD40/HLA-DQA2/TNF/HLA-DQB2	2.71391597707124
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/650	77/9376	2.06065934065934	CCND1/TGFB1/NFKBIA/TGFB2/GRB2/CDKN2A/SHC3/RUNX1/DDB2/NFKB1/MYC	2.55057366860727
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/650	99/9376	1.89414141414141	CCND1/MAPK13/HBEGF/CARM1/GPER1/GRB2/CDKN2C/BCL2/CDKN2A/SHC3/MMP2/ADCY3/NOTCH1	2.44092672203695
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/650	110/9376	1.83586013986014	PFKP/PFKFB3/HIF1A/MKNK1/HK2/ELOB/LDHC/IL6/STAT3/BCL2/IL6R/ENO3/NFKB1/CAMK2G	2.4066809598604
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/650	72/9376	2.0034188034188	MAPK13/TRAF3/NFKBIA/IKBKE/ZNFX1/TNF/TKFC/MAP3K1/NFKB1/MAP3K7	2.33264336285991
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/650	93/9376	1.86124069478908	MAPK13/NFKBIA/JAK3/HLA-DQA2/RBPJ/TYK2/JAK1/NFATC1/IL4R/HLA-DQB2/NOTCH1/NFKB1	2.27801486594084
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/650	93/9376	1.86124069478908	CCND1/ITGA6/TRAF3/NFKBIA/COL4A2/ITGAV/BCL2/CDKN2B/COL4A1/DDB2/NFKB1/MYC	2.27801486594084
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/650	10/9376	4.32738461538461	PAPSS2/SELENBP1/SQOR	2.87316547884531
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/650	138/9376	1.67241917502787	FLOT1/PCK2/RAPGEF1/PHKG1/PYGL/MKNK1/HK2/PRKAR1B/GRB2/PRKAG2/SREBF1/SHC3/CBLB/FBP1/SOCS3/PRKAR2A	2.17182769007018
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/650	138/9376	1.67241917502787	MAPK13/LCP2/NFKBIA/FCGR2A/ITGA4/VAV2/ITGA5/IL6/WAS/TNF/NFATC1/MAP2K3/LIMK1/VAV1/NFKB1/MAP3K7	2.17182769007018
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/650	95/9376	1.82205668016194	TGFB1/CXCL1/TGFB2/IL1A/HLA-DQA2/IL6/TLR2/TNF/MMP1/HLA-DQB2/ITGB2/ITGAL	2.19786438364652
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/650	142/9376	1.62530877573131	PDGFA/MAPK13/ARHGEF2/CYBA/ITGAV/IL1A/GSTM4/BCL2/TNF/MMP2/GSTO2/SDC2/MAP2K5/BMPR1A/NFKB1/MAP3K7	2.04917228298044
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/650	109/9376	1.72036697247706	PCK2/NFKBIA/PYGL/PRKAG2/IL6/STAT3/SREBF1/TNF/PTPA/NR1H3/SOCS3/PRKCD/NFKB1	2.06458217116868
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/650	56/9376	2.06065934065934	CCND1/PTCH2/SCUBE2/BCL2/MGRN1/CSNK1G2/GLI3/IQCE	2.17268462175128
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/650	56/9376	2.06065934065934	CXCL1/NFKBIA/IL6/TLR2/TNF/ITGB2/C3/NFKB1	2.17268462175128
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/650	155/9376	1.58205459057072	FCGR3A/HLA-B/HLA-E/OLR1/HLA-F/CORO1A/FCGR2A/CYBA/ITGAV/HLA-DQA2/ITGA5/TLR2/HLA-DQB2/ITGB2/C3/TUBB8/RAB7B	1.99423010942042
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/650	214/9376	1.48290438533429	HLA-B/HLA-E/LIMK2/MAPK13/AP1B1/HLA-F/NFKBIA/GNG7/ELOB/TNFRSF1B/TLR2/BCL2/TNF/NFATC1/MAP2K3/LIMK1/CCR5/ITPR1/NFKB1/MAP3K7/APOBEC3C/GNB1	1.95032776957725
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	15/650	133/9376	1.62683632157316	FCGR3A/FCER1G/HLA-B/HLA-E/HCST/LCP2/VAV2/GRB2/TNF/SHC3/NFATC1/ITGB2/ITGAL/VAV1/KLRD1	1.98704731973631
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/650	203/9376	1.49220159151194	PDGFA/CCND1/ITGA6/VASP/RAPGEF1/TLN1/ACTN1/ITGA4/COL4A2/ITGAV/ITGA9/VAV2/GRB2/COL1A1/ITGA5/TLN2/BCL2/SHC3/COL4A1/PARVB/VAV1	1.93495134066803
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	29/650	300/9376	1.39437948717949	PDGFA/MAP3K8/DUSP4/GNA12/TAOK3/MAPK13/RASGRP3/DUSP2/TGFB1/MKNK1/TGFB2/CACNA2D4/IL1A/GRB2/MAPKAPK5/RASGRP1/TNF/NFATC1/MAP2K3/FGF18/MAP3K13/ERBB4/MAP3K1/MAP2K5/RELB/NFKB1/MAP3K7/MYC/DUSP9	1.89479580213761
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	21/650	205/9376	1.4776435272045	HLA-B/HLA-E/CCND1/REL/TRAF3/HLA-F/GSN/NFKBIA/JAK3/ACTN1/GRB2/RBPJ/MAD1L1/STAT3/CDKN2B/CDKN2A/JAK1/ATF6B/CCR5/C3/NFKB1	1.8871533518368
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/650	69/9376	1.88147157190635	FCER1G/MAPK13/LCP2/ALOX5/VAV2/GRB2/TNF/MAP2K3/VAV1	2.00568492897253
Organismal Systems	Immune system	hsa04611	Platelet activation	14/650	126/9376	1.60273504273504	FCER1G/VASP/MAPK13/LCP2/FCGR2A/TLN1/COL1A1/TLN2/RASGRP1/ADCY3/ITPR1/APBB1IP/PTGS1/F2R	1.85898360785175
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/650	71/9376	1.82847237269772	CCND1/CGA/MAPK13/GRB2/STAT3/SHC3/IRF1/SOCS3/NFKB1	1.91242198774079
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/650	116/9376	1.61655172413793	VASP/MAPK13/CLDN11/ACTN1/ITGA4/CYBA/VAV2/SIPA1/RASSF5/MMP2/ITGB2/ITGAL/VAV1	1.82359221717845
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/650	41/9376	2.11091932457786	CCND1/HBEGF/CDKN2A/MMP2/MMP1/MYC	1.94559302596328
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	20/650	200/9376	1.44246153846154	GNA12/MAPK13/CLDN11/ARHGEF2/NFKBIA/MYO5C/FCGR2A/MYH9/MYO1C/IL6/TNF/MYO1A/SEC24A/MYO1G/MYO6/F2R/NFKB1/MAP3K7/TUBB8/CASP4	1.72622949418384
Human Diseases	Immune disease	hsa05310	Asthma	5/650	32/9376	2.25384615384615	FCER1G/CD40/HLA-DQA2/TNF/HLA-DQB2	1.93904343986266
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/650	120/9376	1.56266666666667	MAPK13/RAPGEF1/RIPK2/NFKBIA/GRB2/IRAK2/BCL2/SHC3/MAP3K1/MAP2K5/PRKCD/NFKB1/CAMK2G	1.69303076434339
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	15/650	144/9376	1.5025641025641	CCND1/MAPK13/TRAF3/CXCL1/NFKBIA/IKBKE/PRKAG2/IL6/SREBF1/TNF/IL17RA/MAP2K3/C3/NFKB1/MAP3K7	1.65866822378135
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/650	75/9376	1.73095384615385	CCND1/CD82/SESN2/PPP1R13L/ZNF385A/BCL2/CDKN2A/DDB2/SESN3	1.73456459408602
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	16/650	156/9376	1.47944773175542	CCND1/CLDN11/TRAF3/NFKBIA/CFLAR/IKBKE/MX2/GRB2/STAT3/TYK2/JAK1/TNF/NR1H3/SOCS3/NFKB1/MYC	1.64805924264453
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/650	168/9376	1.4596336996337	PDGFA/CCND1/JAK3/GRB2/PIM1/IL6/STAT3/TYK2/BCL2/JAK1/IL6R/IL4R/IL21R/OSM/SOCS3/IL27RA/MYC	1.64065988967714
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/650	54/9376	1.86985754985755	HLA-B/HLA-E/CGA/HLA-F/CD40/HLA-DQA2/HLA-DQB2	1.74954525223718
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/650	76/9376	1.70817813765182	OLR1/PCK2/ACSL5/PLTP/ACSL3/MMP1/PPARD/ACSL1/NR1H3	1.6917747917314
Cellular Processes	Cell motility	hsa04814	Motor proteins	19/650	194/9376	1.41272006344171	TPM4/MYO9B/DNAH17/MYO5C/KIFC3/MYH9/MYO1C/TPM3/ACTA2/KIFAP3/CAPZB/MYO1A/MYO15B/MYO1G/MYO6/ACTR1B/TUBB8/TPM1/KIF26B	1.58534035425022
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/650	122/9376	1.53704918032787	MAP3K8/MAPK13/LCP2/NFKBIA/VAV2/GRB2/RASGRP1/TNF/CBLB/NFATC1/VAV1/NFKB1/MAP3K7	1.62953591974402
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	30/650	333/9376	1.2995148995149	HLA-B/MAGI1/HLA-E/CCND1/ITGA6/PTGER4/TRAF3/HLA-F/IKBKE/ITGA4/MX2/COL4A2/ITGAV/ITGA9/WNT5A/GRB2/COL1A1/ITGA5/RBPJ/LLGL1/TYK2/JAK1/TNF/IRF1/COL4A1/NOTCH1/HES4/HES1/LFNG/NFKB1	1.51886437200499
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/650	77/9376	1.68599400599401	CCND1/RALGDS/TGFB1/TGFB2/STAT3/CDKN2A/JAK1/DDB2/NFKB1	1.64961376517278
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/650	89/9376	1.62074330164218	CD44/ITGA6/ITGA4/COL4A2/ITGAV/ITGA9/COL1A1/ITGA5/COL4A1/MEPE	1.60584651882148
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/650	78/9376	1.66437869822485	MAPK13/IL1A/ITGA5/IL6/TNF/IRF1/ITGB2/C3/NFKB1	1.60806256537076
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/650	90/9376	1.60273504273504	MAPK13/HIF1A/NFKBIA/STAT3/TLR2/RASGRP1/JAK1/NFATC1/MAP2K3/NFKB1	1.56807947092143
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/650	68/9376	1.69701357466063	CCND1/GRB2/PIM1/STAT3/RUNX1/PPARD/NFKB1/MYC	1.57435336776939
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/650	115/9376	1.50517725752508	GNA12/HBEGF/PDE4B/PDE4A/WNK2/BCL2/ADCY3/ATF6B/EGR1/ITPR1/AKAP13/MMP14	1.48764217146281
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/650	17/9376	2.54552036199095	AMACR/CH25H/CYP46A1	1.74068096610132
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/650	17/9376	2.54552036199095	PAPSS2/MTR/KYAT3	1.74068096610132
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	23/650	253/9376	1.31132867132867	CD44/SEPTIN9/UBA52/MAPK13/ARHGEF2/RPS27A/RIPK2/NFKBIA/HK2/TLN1/ACTN1/ITGA5/TLN2/BCL2/TNF/ITPR1/WIPI1/C3/TIFA/PRKCD/NFKB1/MAP3K7/CASP4	1.37007787646682
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/650	37/9376	1.94927234927235	HBA2/IL6/TNF/HBA1/APOL1	1.57897850286039
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/650	70/9376	1.64852747252747	TGFB1/HIF1A/RAPGEF1/TGFB2/ELOB/GRB2/ETS1/FH	1.48638250938509
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/650	18/9376	2.40410256410256	ACSL5/ACSL3/ACSL1	1.62733991468185
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	21/650	232/9376	1.30567639257294	PDGFA/LIMK2/ITGA6/GNA12/GSN/TIAM1/ACTN1/ITGA4/ITGAV/MYH9/ITGA9/VAV2/ITGA5/ABI2/ITGB2/LIMK1/FGF18/ITGAL/FGD3/F2R/VAV1	1.28668576232858
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/650	50/9376	1.73095384615385	TGFB1/CD40/ITGA4/HLA-DQA2/IL6/HLA-DQB2	1.41436651018943
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/650	85/9376	1.52731221719457	NME4/AK7/ADA2/AMPD3/ENTPD1/NUDT16/ADK/RRM1/NT5E	1.33284847234551
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/650	62/9376	1.62858560794045	NCOR2/PSENEN/RBPJ/ATXN1/NOTCH1/HES1/LFNG	1.35527327162715
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	16/650	173/9376	1.33406847487772	TRAF3/NFKBIA/TLR7/IKBKE/MX2/IL1A/HLA-DQA2/IL6/TYK2/JAK1/TNF/CIITA/SLC25A6/HLA-DQB2/SOCS3/NFKB1	1.21039897472594
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/650	41/9376	1.75909943714822	PSAT1/GAMT/SDS/SARDH/CHDH	1.32943818534207
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/650	76/9376	1.51838056680162	PDGFA/CCND1/GRB2/CDKN2A/SHC3/CAMK1D/DDB2/CAMK2G	1.23836522029092
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	18/650	201/9376	1.29175660160735	PDGFA/ID2/REL/ETV6/TSPAN7/CD40/NFKBIZ/CDKN2C/IL6/PLAU/DOT1L/RUNX1/ETV7/SPINT1/KLF3/DDB2/NFKB1/MYC	1.14117013151124
NA	NA	hsa04981	Folate transport and metabolism	4/650	31/9376	1.86124069478908	FOLR3/SLCO2B1/MTR/FPGS	1.31084230472904
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/650	103/9376	1.40044809559373	MAPK13/TGFB1/NFKBIA/CFLAR/TGFB2/IL6/TLR2/TNF/C3/NFKB1	1.11529415788364
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/650	91/9376	1.42661031276416	RASGRP3/NFKBIA/VAV2/GRB2/LILRB3/NFATC1/LILRB1/VAV1/NFKB1	1.11608122935256
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/650	91/9376	1.42661031276416	PDE4B/GNG7/PDE4A/PDE2A/ADCY3/PDE8A/GRK5/GABRA3/GNB1	1.11608122935256
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/650	116/9376	1.36785145888594	PFKP/ME2/HK2/PSAT1/PGP/ENO3/SDS/TKFC/FBP1/FH/PCCA	1.08800451160862
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/650	67/9376	1.50704936854191	PFKP/PCK2/HK2/ALDH3B1/LDHC/ENO3/FBP1	1.13676539528576
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/650	80/9376	1.44246153846154	PDGFA/GRB2/IL6/STAT3/BCL2/JAK1/SHC3/IL6R	1.08469383860329
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	21/650	248/9376	1.22143920595533	MAPK13/RIPK2/NFKBIA/CASP5/DNM2/IL6/TLR2/BCL2/TNF/FHOD1/MAP2K3/ARL8B/MYO6/EXOC4/ACTR1B/NFKB1/MAP3K7/TUBB8/RAB7B/MYC/CASP4	0.964555567977201
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	15/650	170/9376	1.27276018099548	MAGI1/CCND1/VASP/CLDN11/ARHGEF2/TIAM1/ACTN1/MYH9/PRKAG2/LLGL1/MICALL2/WAS/RUNX1/MAP3K1/NEDD4L	0.979500489943075
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/650	82/9376	1.40727954971857	HLA-B/HLA-E/HLA-F/HLA-DQA2/TNF/CIITA/HLA-DQB2/KLRD1	1.01095752253749
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/650	71/9376	1.4221451787649	SLC7A5/PFKP/HIF1A/SLC16A3/HK2/LDHC/MYC	0.974467886309724
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/650	47/9376	1.53453355155483	ME2/PCK2/LDHC/ACYP2/FH	1.00263085339872
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/650	110/9376	1.31132867132867	SMAD7/ID2/TGFB1/SKI/SKIL/TGFB2/CDKN2B/TNF/BMPR1A/MYC	0.89640449378376
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/650	362/9376	1.15556311092223	PDGFA/MAGI1/CCND1/ITGA6/PCK2/JAK3/ITGA4/GNG7/COL4A2/ITGAV/ITGA9/GRB2/COL1A1/ITGA5/IL6/TLR2/BCL2/JAK1/IL6R/IL4R/OSM/ATF6B/COL4A1/FGF18/ERBB4/F2R/NFKB1/MYC/GNB1	0.823828553081477
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/650	73/9376	1.3831822971549	BICD1/MX2/MDFIC/CHMP4B/ELL/CCR5/APOBEC3C	0.896995095467991
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/650	73/9376	1.3831822971549	CCND1/JAK3/GRB2/RASSF5/STAT3/CDKN2A/DDB2	0.896995095467991
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/650	99/9376	1.31132867132867	FCGR3A/FPR1/FPR2/FCGR2A/HLA-DQA2/HLA-DQB2/ITGB2/ITGAL/C3	0.849899648046303
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/650	49/9376	1.47189952904239	GALNT3/GALNT6/XXYLT1/LFNG/COLGALT2	0.903881104745349
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/650	37/9376	1.55941787941788	CCND1/TPM3/DDB2/MYC	0.93051146638124
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/650	87/9376	1.32640141467728	CCND1/RALGDS/TGFB1/TGFB2/GRB2/BCL2/DDB2/MYC	0.834760497961755
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	14/650	166/9376	1.21653382761816	ATP1B3/EDNRB/GNA12/VASP/PDE2A/ADRA2B/SLC8A1/SLC8A2/NFATC1/ADCY3/ATF6B/SLC25A6/ITPR1/KCNMB4	0.768218380603492
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/650	38/9376	1.51838056680162	JAK3/CD40/CIITA/IGLL1	0.873872933064178
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/650	154/9376	1.21766233766234	ATP1B3/TPM4/MAPK13/CACNA2D4/TPM3/SLC8A1/SLC8A2/BCL2/ADCY3/ATF6B/KCNQ1/TPM1/CAMK2G	0.743302858214756
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/650	168/9376	1.20205128205128	JAK3/PYGL/CFLAR/IL1A/STAT3/TYK2/BCL2/CHMP4B/JAK1/TNF/SLC25A6/PARP1/TNFAIP3/CAMK2G	0.721220907830661
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/650	142/9376	1.21898158179848	UBA52/RPS27A/ELOB/ERCC8/UBE2U/UBE2G2/CBLB/MGRN1/DDB2/MAP3K1/NEDD4L/SOCS3	0.717615049268843
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/650	39/9376	1.47944773175542	MTHFD1L/MTR/SARDH/CHDH	0.818850473792857
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/650	103/9376	1.26040328603435	ATP1B3/COL4A2/DPP4/COL1A1/SLC8A1/SLC8A2/COL4A1/SLC16A10/KCNQ1	0.72525320210904
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/650	144/9376	1.20205128205128	ID2/MAPK13/SKIL/JAK3/WNT5A/GRB2/STAT3/JAK1/JARID2/BMPR1A/MYC/DUSP9	0.666852326703928
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/650	16/9376	1.80307692307692	ALDH3B1/IL4I1	0.877432922112844
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/650	106/9376	1.22473149492017	PDGFA/CCND1/NFKBIA/GRB2/FOLR3/PLAU/BCL2/SPINT1/NFKB1	0.635055553870604
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/650	133/9376	1.19301330248699	CCND1/MAPK13/TGFB1/PCK2/TGFB2/PLK3/GRB2/PRKAG2/IL6/STAT3/CDKN2B	0.611844834418159
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/650	54/9376	1.33561253561254	ERCC1/EME2/HES1/SLX1A/FANCA	0.675017786956438
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/650	107/9376	1.2132854061826	PFKP/PCK2/PHKG1/PYGL/PRKAG2/LDHC/ITPR1/FBP1/CAMK2G	0.605579688588822
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/650	17/9376	1.69701357466063	CA13/CA12	0.785028973001078
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/650	42/9376	1.37377289377289	ACSL5/ACSL3/ACSL1/SLC39A8	0.662572279459321
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/650	122/9376	1.18234552332913	CCND1/PFKP/PFKFB3/PCK2/TBC1D1/PRKAG2/SREBF1/PFKFB4/FBP1/MAP3K7	0.553280017833627
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/650	122/9376	1.18234552332913	MAPK13/GRB2/STAT3/SHC3/ADCY3/ATF6B/MAP2K3/ITPR1/MAP3K1/SOCS3	0.553280017833627
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/650	18/9376	1.60273504273504	ZNF143/MTR	0.698563493933309
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/650	31/9376	1.39593052109181	SMOX/DPYS/ALDH3B1	0.602621868567953
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/650	250/9376	1.09627076923077	HLA-B/AGAP3/HLA-E/DAB2/HLA-F/EPN1/GRK7/DNM2/FOLR3/ASAP1/CHMP4B/PSD4/CBLB/RAB11FIP4/CAPZB/CCR5/GRK5/STAMBP/NEDD4L	0.42107448512285
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/650	195/9376	1.10958579881657	FCGR3A/FPR1/FPR2/MAPK13/TLR7/FCGR2A/CYBA/TLR2/SLC25A6/ITGB2/ITGAL/C3/NFKB1/MAP3K7/CASP4	0.422047470695592
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/650	140/9376	1.13336263736264	CCND1/GNG7/PRKAG2/ACTA2/SLC8A1/SLC8A2/ADCY3/EGR1/ITPR1/SPHK1/GNB1	0.43390129206806
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/650	99/9376	1.16562548562549	MAPK13/PTGER4/PRKCH/ADCY3/MAP2K3/ITPR1/PRKCD/CAMK2G	0.452142879548642
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/650	99/9376	1.16562548562549	PDGFA/RALGDS/HIF1A/CHKB/GRB2/WAS/DGKI/GPCPD1	0.452142879548642
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/650	86/9376	1.17409660107335	HBEGF/GRB2/SHC3/CBLB/ERBB4/MYC/CAMK2G	0.44265601827954
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/650	59/9376	1.22242503259452	NME4/DPYS/ENTPD1/RRM1/NT5E	0.467741962144674
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/650	169/9376	1.10958579881657	UBA52/STX17/HIF1A/RPS27A/ATG10/CFLAR/NRBF2/BCL2/ITPR1/WIPI1/PRKCD/MAP3K7/RAB7B	0.392349651021936
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/650	100/9376	1.15396923076923	CXCL1/TNFRSF1B/CX3CR1/IL6/TNF/IL6R/CCL14/CCR5	0.422462614326059
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/650	170/9376	1.10305882352941	CCND1/TGFB1/TGFB2/WNT5A/SMARCA4/GRB2/GSTM4/CDKN2A/SHC3/SMARCE1/GSTO2/DDB2/MYC	0.370091293280416
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	19/650	254/9376	1.07900666262871	PDGFA/EDNRB/PHKG1/ORAI3/SLC8A1/SLC8A2/NFATC1/ADCY3/P2RX4/SLC25A6/CAMK1D/ITPR1/ORAI2/FGF18/SPHK1/ERBB4/F2R/GRIN2C/CAMK2G	0.348393668201305
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/650	88/9376	1.14741258741259	CD55/F13A1/SERPINA1/PLAU/ITGB2/C3/F2R	0.379183572496883
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/650	47/9376	1.22762684124386	HK2/TNF/SOCS3/PRKCD	0.426962336468751
NA	NA	hsa04517	IgSF CAM signaling	22/650	299/9376	1.06134293799846	UNC5C/MAGI1/MAPK13/LCP2/ANK2/UNC5B/ACTN1/ITGA4/MYH9/CD84/VAV2/GRB2/NECTIN2/ITGA5/APP/ITGB2/NPHS1/ITGAL/KIRREL2/VAV1/TUBB8/EPB41L3	0.2942142551499
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/650	61/9376	1.18234552332913	ATP1B3/ATOX1/MT2A/SLC8A1/SLC8A2	0.389944954815328
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/650	75/9376	1.15396923076923	PFKP/PSAT1/ASL/MTR/ENO3/SDS	0.365371326351509
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/650	75/9376	1.15396923076923	ERCC1/GSTM4/BCL2/CDKN2A/XPA/GSTO2	0.365371326351509
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/650	34/9376	1.27276018099548	CRY2/BHLHE41/PRKAG2	0.434845729353176
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/650	117/9376	1.10958579881657	CHD3/BAZ2B/BAZ1A/SMARCA4/SMARCE1/CECR2/BICRAL/BRD9/GATAD2A	0.325536641587484
NA	NA	hsa03272	Virion - Hepatitis viruses	4/650	48/9376	1.20205128205128	CLDN11/DPP4/CHMP4B/SLC10A1	0.38302107658074
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	13/650	174/9376	1.07770114942529	WFS1/RRBP1/MAN1C1/MAN1B1/ERO1B/BCL2/PPP1R15A/UBE2G2/ATF6B/SEC62/SEC24A/ERLEC1/TMEM258	0.282355118638397
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/650	21/9376	1.37377289377289	VNN2/DPYS	0.467983204101102
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/650	104/9376	1.10958579881657	PLD4/PLB1/PGS1/CHKB/DGKI/CDS1/GPCPD1/PISD	0.306703652585705
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/650	105/9376	1.09901831501832	RABGEF1/TOMM7/UBA52/CCZ1/HIF1A/RPS27A/TOMM40L/RAB7B	0.278472044219534
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/650	63/9376	1.14481074481074	POLR2L/ERCC1/ERCC8/XPA/DDB2	0.314746545866068
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/650	78/9376	1.10958579881657	PLCH1/INPP5K/INPP4B/INPP4A/PLCH2/IPPK	0.265241527526421
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/650	78/9376	1.10958579881657	PFKP/BTG2/DIS3L/NUDT16/ENO3/PNPT1	0.265241527526421
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/650	149/9376	1.06490449148167	FCER1G/PDGFA/RALGDS/GNA12/DNM2/GRB2/SHC3/ADCY3/DGKI/SPHK1/F2R	0.217957760907426
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/650	36/9376	1.20205128205128	ST3GAL1/GALNT3/GALNT6	0.331492826661379
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/650	50/9376	1.15396923076923	SMS/PRODH2/SMOX/GAMT	0.297924314572651
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/650	150/9376	1.05780512820513	CCND1/TGFB1/TGFB2/WNT5A/GRB2/BCL2/CDKN2B/SHC3/DDB2/FGF18/MYC	0.194778037307919
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/650	23/9376	1.2543143812709	ATP1B3/PCK2	0.333268358889114
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/650	238/9376	1.03032967032967	PDGFA/RALGDS/REL/RASGRP3/RASA3/TIAM1/ETS2/GNG7/GRB2/RASSF5/RASGRP1/SHC3/FGF18/ETS1/RASAL3/NFKB1/GNB1	0.129349663607499
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/650	139/9376	1.03774211400111	HBEGF/GPER1/GRB2/BCL2/SHC3/MMP2/ADCY3/ATF6B/ITPR1/PRKCD	0.122349686985306
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/650	298/9376	1.01649974186887	TGFB1/CXCL1/RELT/TGFB2/CD40/TNFRSF1B/IL1A/CX3CR1/IL6/IL17D/TNF/IL6R/CCL14/IL4R/IL21R/OSM/IL17RA/IL17B/CCR5/BMPR1A/IL27RA	0.078999602297073
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	16/650	226/9376	1.02121170864534	ATP1B3/CGA/GRIA4/TIAM1/NFKBIA/PDE4B/PDE4A/VAV2/NFATC1/ADCY3/GLI3/F2R/VAV1/GRIN2C/NFKB1/CAMK2G	0.0880955635183789
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/650	24/9376	1.20205128205128	NDST2/XYLT1	0.270489053642674
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/650	53/9376	1.08865021770682	ATP1B3/DNM2/SLC8A1/SLC8A2	0.176634125030151
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/650	82/9376	1.05545966228893	NME4/DPYS/GSTM4/GSTO2/RRM1/CES2	0.137663093634642
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/650	97/9376	1.04095162569389	GRIA4/GNG7/ADCY3/ITPR1/GRIN2C/GNB1/CAMK2G	0.110647381066774
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	11/650	155/9376	1.023682382134	CCND1/WNT5A/CDKN2C/CDKN2B/CDKN2A/ADCY3/ATF6B/PDE8A/ITPR1/FH/CAMK2G	0.0811403608519002
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/650	98/9376	1.03032967032967	ATP1B3/PDE2A/ADCY3/ATF6B/CAMK1D/ITPR1/CAMK2G	0.0823736396765355
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/650	157/9376	1.0106418422342	SMAD7/CCND1/ID2/TGFB1/TGFB2/WNT5A/LLGL1/ITGB2/SAV1/BMPR1A/MYC	0.0366994408237824
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/650	41/9376	1.05545966228893	GRIA4/GABRA3/GRIN2C	0.0971285040996328
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/650	71/9376	1.01581798483207	MAPK13/HBEGF/CXCL1/NFKBIA/NFKB1	0.0365137848786624
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/650	116/9376	0.994801061007958	GRIA4/DLGAP1/GNG7/ADCY3/ITPR1/SHANK1/GRIN2C/GNB1	-0.0153770467461268
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/650	57/9376	1.01225371120108	ACSL5/ACSL3/ACSL1/ELOVL7	0.0253253306760356
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/650	73/9376	0.987987355110643	PDGFA/CCND1/CDKN2A/DDB2/FGF18	-0.0281205150377711
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/650	43/9376	1.00636851520572	ACSL5/ACSL3/ACSL1	0.0114234292732735
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/650	178/9376	0.972445980985307	ROR1/CCND1/PRICKLE2/FOSL1/CCDC88C/WNT5A/NFATC1/ANKRD6/PPARD/MAP3K7/MYC/CAMK2G	-0.101293823478985
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/650	28/9376	1.03032967032967	FPGS/GCH1	0.0438653971508844
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/650	89/9376	0.972445980985307	PDGFA/GRB2/ADCY3/ITPR1/MAP2K5/TUBB8	-0.0712815191033539
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/650	59/9376	0.977940026075619	SMS/GSTM4/GSTO2/RRM1	-0.046390351696881
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/650	59/9376	0.977940026075619	CCND1/GRB2/DDB2/MYC	-0.046390351696881
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/650	44/9376	0.983496503496503	MAN1C1/MAN1B1/TMEM258	-0.0299467468162875
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/650	44/9376	0.983496503496503	APTX/PARP1/TDG	-0.0299467468162875
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/650	90/9376	0.961641025641025	SESN2/PRKAG2/ADCY3/ATF6B/SESN3/NFKB1	-0.0997949612237008
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/650	75/9376	0.961641025641025	ATP1B3/CGA/ADCY3/ATF6B/ITPR1	-0.0910264295599949
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/650	29/9376	0.994801061007958	RASSF4/SAV1	-0.00765265810506433
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/650	29/9376	0.994801061007958	GRK7/GNB1	-0.00765265810506433
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/650	76/9376	0.948987854251012	ATP1B3/ADCY3/ITPR1/KCNQ1/CAMK2G	-0.121863494030503
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/650	122/9376	0.945876418663304	ATP1B3/CCND1/PFKP/HIF1A/ITGAV/NOTCH1/SLC16A10/MYC	-0.164223916773301
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/650	30/9376	0.961641025641025	PCK2/FH	-0.0574314045684332
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/650	93/9376	0.930620347394541	ACTN1/NECTIN2/HEG1/WAS/SNAI1/MAP3K7	-0.183511857933922
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/650	14/9376	1.03032967032967	ST3GAL1	0.0309943192004563
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/650	31/9376	0.930620347394541	PFKP/FBP1	-0.105598567593131
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/650	31/9376	0.930620347394541	PGP/PCCA	-0.105598567593131
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/650	31/9376	0.930620347394541	SRPRA/SEC62	-0.105598567593131
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/650	63/9376	0.915848595848596	PTCH2/WNT5A/GLI3/DDB2	-0.182903304730939
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/650	125/9376	0.923175384615385	FCER1G/GNA12/MAPK13/BCL2/TNF/SPHK1/SGPP2/NFKB1	-0.235991180581215
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/650	48/9376	0.901538461538462	IL4I1/PCCA/IVD	-0.186649864729701
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/650	48/9376	0.901538461538462	ATP1B3/HK2/SLC2A5	-0.186649864729701
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/650	15/9376	0.961641025641025	ST3GAL1	-0.0405775858821785
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/650	15/9376	0.961641025641025	AK7	-0.0405775858821785
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/650	32/9376	0.901538461538462	PFKP/HK2	-0.152268441903326
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/650	32/9376	0.901538461538462	LDHC/PCCA	-0.152268441903326
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/650	32/9376	0.901538461538462	ATG10/WIPI1	-0.152268441903326
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	10/650	158/9376	0.912950340798442	TFDP2/CCND1/TGFB1/TGFB2/CDC14B/CDKN2C/MAD1L1/CDKN2B/CDKN2A/MYC	-0.301170187254652
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	16/650	250/9376	0.923175384615385	LAPTM5/AP1B1/STX17/ARSG/TLR7/BORCS7/CTSC/GGA1/GALNS/MEAK7/ACP2/SLC11A1/SLC29A3/ARL8B/ROGDI/BORCS5	-0.336019807739304
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/650	65/9376	0.887668639053254	ADCY3/ATF6B/PDE8A/ITPR1	-0.248024308676536
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/650	49/9376	0.883139717425432	ATF6B/GRIN2C/NFKB1	-0.223835360736007
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/650	33/9376	0.874219114219114	STX17/STX11	-0.197543687567492
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/650	98/9376	0.883139717425432	INPP4B/DGKI/CDS1/ITPR1/INPP4A/IPPK	-0.317385804219529
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/650	16/9376	0.901538461538462	ST3GAL1	-0.107577982787782
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/650	83/9376	0.868952734012975	POLR2L/NFKBIA/IKBKE/IL6/NFKB1	-0.327283231482889
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/650	115/9376	0.878020066889632	GNG7/BCL2/ADCY3/ITPR1/KCNQ1/GNB1/CAMK2G	-0.359205585493298
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/650	115/9376	0.878020066889632	ALOX5/GNG7/CYP4X1/APP/ITPR1/PTGS1/GNB1	-0.359205585493298
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/650	34/9376	0.848506787330317	POLR2L/CRCP	-0.241516838399873
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/650	17/9376	0.848506787330317	MYH9	-0.170623020099169
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/650	148/9376	0.877172557172557	CCND1/WNT5A/GRB2/SHC3/DDB2/FGF18/NOTCH1/HES1/MYC	-0.411061863978116
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/650	52/9376	0.832189349112426	CGA/ALOX5/ADCY3	-0.331172886576364
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/650	52/9376	0.832189349112426	APOC1/APOC2/PLTP	-0.331172886576364
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/650	133/9376	0.867646038172354	SCN1A/MAPK13/GRIA4/GNG7/ATF6B/ITPR1/GNB1/CAMK2G	-0.419557029570452
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/650	69/9376	0.836209587513935	GRIA4/ATF6B/GRIN2C/CAMK2G	-0.37268582709142
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/650	134/9376	0.861171067738232	GNA12/MYH9/PRKCH/ACTA2/ADCY3/ITPR1/KCNMB4/PRKCD	-0.441757684362776
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/650	86/9376	0.838640429338104	ATP1B3/ADCY3/ATF6B/KCNMB4/CAMK2G	-0.410270991048238
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/650	36/9376	0.801367521367521	PYGL/HK2	-0.325883810981829
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/650	37/9376	0.77970893970894	IL4I1/ASL	-0.366422606577064
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/650	37/9376	0.77970893970894	ALDH3B1/IL4I1	-0.366422606577064
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/650	184/9376	0.862341137123746	UNC5C/LIMK2/SEMA3D/UNC5B/WNT5A/SEMA6A/EPHB2/LIMK1/EPHB1/SEMA3C/CAMK2G	-0.51468651964884
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/650	137/9376	0.842313307130825	NFKBIA/CFLAR/CTSC/BCL2/TNF/ITPR1/PARP1/NFKB1	-0.507431656038302
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/650	55/9376	0.786797202797203	CERK/SPHK1/SGPP2	-0.432790482126996
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/650	19/9376	0.75919028340081	GALNS	-0.286759097260603
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/650	89/9376	0.810371650821089	SLC12A5/GNG7/ADCY3/GABRA3/GNB1	-0.490563528584563
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/650	154/9376	0.842997002997003	CCND1/CACNA2D4/PRKAG2/NFATC1/ADCY3/CAMK1D/ITPR1/MAP2K5/CAMK2G	-0.53615511840018
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/650	38/9376	0.75919028340081	NNMT/NT5E	-0.405950968905477
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/650	38/9376	0.75919028340081	ATP1B3/NEDD4L	-0.405950968905477
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/650	56/9376	0.772747252747253	MAN1C1/MAN1B1/TMEM258	-0.465510961228932
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/650	20/9376	0.721230769230769	CYB5R3	-0.340603761750251
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/650	143/9376	0.806971490048413	FCGR3A/FCGR2A/CD40/ACTN1/HLA-DQA2/TNF/HLA-DQB2/C3	-0.634823172886343
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/650	59/9376	0.733455019556714	CGA/ADCY3/PTGS1	-0.560522665538436
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/650	22/9376	0.655664335664336	ALDH3B1	-0.441295375783447
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/650	42/9376	0.686886446886447	IL4I1/KYAT3	-0.555043889143304
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/650	78/9376	0.739723865877712	SEPTIN9/DNM2/ITGA5/SHC3	-0.62997249770314
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/650	23/9376	0.627157190635452	ASL	-0.488594905956844
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/650	23/9376	0.627157190635452	FUT4	-0.488594905956844
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/650	23/9376	0.627157190635452	PDSS1	-0.488594905956844
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/650	62/9376	0.697965260545906	PRKAG2/ADCY3/CLPB	-0.651207416005278
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/650	44/9376	0.655664335664336	TAF7L/TAF11	-0.62482110730254
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/650	63/9376	0.686886446886447	ALOX5/PLB1/PTGS1	-0.680553155327947
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/650	217/9376	0.797674583481035	CCND1/IKBKE/GRB2/GSTM4/STAT3/BCL2/ADCY3/ATF6B/GSTO2/FGF18/NFKB1/MYC	-0.822983243443328
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/650	83/9376	0.69516218721038	AMACR/ACSL5/ACSL3/ACSL1	-0.761315420787494
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/650	65/9376	0.665751479289941	MOGAT1/DGKI/TKFC	-0.738010806390655
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/650	65/9376	0.665751479289941	CGA/GPER1/ITPR1	-0.738010806390655
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/650	26/9376	0.554792899408284	PLB1	-0.620408391017154
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/650	26/9376	0.554792899408284	HES1	-0.620408391017154
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/650	26/9376	0.554792899408284	PLB1	-0.620408391017154
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/650	67/9376	0.645878300803674	ITPR1/GRIN2C/CAMK2G	-0.793913410293317
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/650	27/9376	0.534245014245014	ELOVL7	-0.66144163269907
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/650	323/9376	0.803848535365563	CD44/PDGFA/CCND1/TGFB2/DNMT3A/GRB2/PIM1/ITGA5/STAT3/PLAU/BCL2/CDKN2A/VIM/DNMT1/NOTCH1/NFKB1/TPM1/MYC	-0.979109509137675
NA	NA	hsa04519	Cadherin signaling	23/650	404/9376	0.821203351104341	PRICKLE2/VASP/TAOK3/MAPK13/TMC6/PSENEN/NFKBIA/ACTN1/PCDH18/MYO1C/WNT5A/VAV2/ABI2/VIM/ANKRD6/MAP2K3/MYO1A/SAV1/MYO1G/GABRA3/CDH23/VAV1/NFKB1	-1.00262871158955
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/650	28/9376	0.515164835164835	ELOVL7	-0.701210624020658
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/650	28/9376	0.515164835164835	FUT4	-0.701210624020658
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/650	28/9376	0.515164835164835	SLC12A7	-0.701210624020658
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/650	51/9376	0.565671191553545	PLD4/PLB1	-0.848816897421727
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/650	51/9376	0.565671191553545	ADCY3/KCNQ1	-0.848816897421727
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/650	144/9376	0.701196581196581	NRBF2/RBPJ/ATXN1/SLC25A6/ITPR1/WIPI1/GRIN2C	-0.986174168425099
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/650	30/9376	0.480820512820513	PIGX	-0.777320240442271
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/650	30/9376	0.480820512820513	PLB1	-0.777320240442271
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/650	73/9376	0.592792413066386	ALDH3B1/GSTM4/GSTO2	-0.953236125543533
NA	NA	hsa04082	Neuroactive ligand signaling	10/650	199/9376	0.724855044453035	GRIA4/GNG7/ADRA2B/TAC3/ADCY3/P2RX4/GABRA3/GRIN2C/GNB1/P2RY6	-1.07071143158561
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/650	93/9376	0.620413564929694	ATP1B3/CST3/ADCY3/ITPR1	-1.00402076589218
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/650	32/9376	0.450769230769231	BCL2	-0.849372402491989
NA	NA	hsa04081	Hormone signaling	11/650	219/9376	0.724524060414471	CGA/GNA12/GNG7/GPER1/ITGAV/ADRA2B/STAT3/ADCY3/SLC16A10/BMPR1A/GNB1	-1.12580671710365
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/650	79/9376	0.547770204479065	ALDH3B1/GSTM4/GSTO2	-1.10163066172867
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/650	79/9376	0.547770204479065	SYT1/DNM2/CPLX1	-1.10163066172867
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/650	101/9376	0.571271896420411	EDNRB/WNT5A/ADCY3/CAMK2G	-1.18228013592346
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/650	60/9376	0.480820512820513	MAPK13/SPHK1	-1.10106541786272
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/650	60/9376	0.480820512820513	GNA12/ITPR1	-1.10106541786272
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/650	158/9376	0.63906523855891	SLC7A5/SESN2/PRR5/WNT5A/GRB2/TNF/CLIP1	-1.24874457507332
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/650	102/9376	0.565671191553545	ATP1B3/ADCY3/ITPR1/KCNQ1	-1.20370451292109
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/650	37/9376	0.38985446985447	HK2	-1.01488964305622
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/650	83/9376	0.521371640407785	JARID2/YAF2/BCOR	-1.1953476100921
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/650	38/9376	0.379595141700405	HK2	-1.0458629198903
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/650	63/9376	0.457924297924298	DOT1L/COLGALT2	-1.17820300592495
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/650	41/9376	0.351819887429644	BABAM2	-1.1351811771428
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/650	90/9376	0.480820512820513	ATP1B3/SLC10A1/ADCY3	-1.35070078533255
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/650	69/9376	0.418104793756968	PTGER4/ITPR1	-1.324034129517
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/650	44/9376	0.327832167832168	ADCY3	-1.21969546778879
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/650	70/9376	0.412131868131868	GSTM4/GSTO2	-1.34735527182568
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/650	45/9376	0.320547008547009	ABCG1	-1.24691339227845
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/650	154/9376	0.561998001998002	MTHFD1L/NME4/AK7/PSAT1/FPGS/GCH1	-1.49574860086138
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/650	138/9376	0.52263099219621	MAPK13/MAD1L1/ADCY3/ITPR1/CAMK2G	-1.54184066729897
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/650	191/9376	0.528650825614176	GNG7/GRB2/SHC3/ATF6B/SLC29A3/GRIN2C/GNB1	-1.79619947951541
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/650	108/9376	0.400683760683761	EIF4A3/NUP210L/TNPO2	-1.70965949689466
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/650	110/9376	0.393398601398601	MAPK13/MAD1L1/ADCY3	-1.74657932185037
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/650	86/9376	0.335456171735242	TAS1R1/GABRA3	-1.68966150503991
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/650	68/9376	0.212126696832579	DHRS4L2	-1.77957938454951
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/650	370/9376	0.584781704781705	FPR1/CGA/FPR2/EDNRB/GRIA4/PTGER4/ADRA2B/TAC3/RXFP1/P2RX4/C3/GABRA3/F2R/GRIN2C/P2RY6	-2.22405787267807
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/650	103/9376	0.140044809559373	EIF4A3	-2.39507444408775
NA	NA	hsa04382	Cornified envelope formation	5/650	217/9376	0.332364409783765	ITGA6/CLDN11/COL4A2/COL4A1/TGM3	-2.71568897733052
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/650	183/9376	0.236469104665826	GNL3L/GTPBP4/BMS1	-2.84680842177987
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/650	243/9376	0.23744222855334	EIF4A3/DDX46/PRPF6/DHX16	-3.28703154261669
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/650	449/9376	0.28913482953572	OR5AU1/GNG7/PDE2A/SLC8A1/SLC8A2/ADCY3/OR2B11/GNB1/CAMK2G	-4.21300865553497