ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 51/1193 175/18639 0.291428571428571 4.55317447012334 1.01396693890528e-20 1.13969883932954e-17 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 23/1193 68/18639 0.338235294117647 5.28446575612642 1.40677418930988e-11 5.29623627963243e-09 GO:0008137 NADH dehydrogenase (ubiquinone) activity 18/1193 41/18639 0.439024390243902 6.85915809702942 1.41358619563143e-11 5.29623627963243e-09 GO:0003954 NADH dehydrogenase activity 18/1193 44/18639 0.409090909090909 6.39148822677741 5.98870049729643e-11 1.6828248397403e-08 GO:0015078 proton transmembrane transporter activity 35/1193 185/18639 0.189189189189189 2.95582338415532 6.20511283511534e-09 1.15613520980222e-06 GO:0030695 GTPase regulator activity 66/1193 489/18639 0.134969325153374 2.10871186214061 6.63168008100281e-09 1.15613520980222e-06 GO:0060589 nucleoside-triphosphatase regulator activity 66/1193 490/18639 0.13469387755102 2.1044083685444 7.20013031015616e-09 1.15613520980222e-06 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 18/1193 58/18639 0.310344827586207 4.8487152065208 1.10892966844506e-08 1.55804618416531e-06 GO:0009055 electron transfer activity 26/1193 116/18639 0.224137931034483 3.50184987137613 1.49478649873041e-08 1.86682224952553e-06 GO:0016651 oxidoreductase activity, acting on NAD(P)H 21/1193 88/18639 0.238636363636364 3.72836813228682 1.14671049290447e-07 1.28890259402462e-05 GO:0022853 active monoatomic ion transmembrane transporter activity 23/1193 118/18639 0.194915254237288 3.04528535098811 1.4037716122414e-06 0.000143439935650849 GO:0022804 active transmembrane transporter activity 56/1193 457/18639 0.12253829321663 1.91449392059075 2.19163984922714e-06 0.000205283599210942 GO:0051015 actin filament binding 31/1193 209/18639 0.148325358851675 2.31738169625848 1.03391110371632e-05 0.000831973205296732 GO:0005096 GTPase activator activity 37/1193 271/18639 0.136531365313653 2.13311661197081 1.06203716111276e-05 0.000831973205296732 GO:0005085 guanyl-nucleotide exchange factor activity 33/1193 230/18639 0.143478260869565 2.2416523925799 1.11028452664155e-05 0.000831973205296732 GO:0016208 AMP binding 6/1193 12/18639 0.5 7.81181894383906 4.48729942384734e-05 0.00315232784525276 GO:0003779 actin binding 49/1193 443/18639 0.110609480812641 1.72812247516079 0.000131146266406783 0.0086710825553661 GO:0002020 protease binding 21/1193 136/18639 0.154411764705882 2.41247349736206 0.000149014201413287 0.00882101522220521 GO:0015399 primary active transmembrane transporter activity 24/1193 166/18639 0.144578313253012 2.25883921267635 0.000149109687919839 0.00882101522220521 GO:0050700 CARD domain binding 6/1193 15/18639 0.4 6.24945515507125 0.000205678763686909 0.0115591465192043 GO:1990948 ubiquitin ligase inhibitor activity 5/1193 11/18639 0.454545454545455 7.10165358530824 0.000355339200277287 0.0190191076719843 GO:0004857 enzyme inhibitor activity 44/1193 416/18639 0.105769230769231 1.65250016119672 0.000732469979900374 0.03742255715491 GO:0140828 metal cation:monoatomic cation antiporter activity 9/1193 41/18639 0.219512195121951 3.42957904851471 0.00095011863361701 0.0464318845298052 GO:0008237 metallopeptidase activity 23/1193 184/18639 0.125 1.95295473595977 0.00159790617881197 0.0699668623784261 GO:0004674 protein serine/threonine kinase activity 44/1193 433/18639 0.10161662817552 1.58762140198115 0.00163690106458115 0.0699668623784261 GO:0005516 calmodulin binding 25/1193 207/18639 0.120772946859903 1.88691278836692 0.00167170382498266 0.0699668623784261 GO:0004222 metalloendopeptidase activity 16/1193 110/18639 0.145454545454545 2.27252914729864 0.00168069865143906 0.0699668623784261 GO:0106310 protein serine kinase activity 38/1193 361/18639 0.105263157894737 1.64459346186086 0.00177404282154592 0.071215147550629 GO:0055105 ubiquitin-protein transferase inhibitor activity 5/1193 15/18639 0.333333333333333 5.20787929589271 0.00186167335931485 0.0721558915817205 GO:0042578 phosphoric ester hydrolase activity 38/1193 363/18639 0.104683195592287 1.63553234085887 0.00195667822811249 0.0733102109466147 GO:0051219 phosphoprotein binding 14/1193 93/18639 0.150537634408602 2.35194548846767 0.00230242289955493 0.0834813980354757 GO:0019902 phosphatase binding 23/1193 190/18639 0.121052631578947 1.89128248113998 0.00243343440164241 0.0835204463359557 GO:0004860 protein kinase inhibitor activity 13/1193 84/18639 0.154761904761905 2.41794395880733 0.0025336150602253 0.0835204463359557 GO:0031720 haptoglobin binding 4/1193 10/18639 0.4 6.24945515507125 0.00256627447288645 0.0835204463359557 GO:0001784 phosphotyrosine residue binding 9/1193 47/18639 0.191489361702128 2.99176044657666 0.00261724410976798 0.0835204463359557 GO:0001221 transcription coregulator binding 16/1193 115/18639 0.139130434782609 2.1737235321987 0.00267503208905196 0.0835204463359557 GO:0015291 secondary active transmembrane transporter activity 31/1193 287/18639 0.10801393728223 1.68757064291994 0.00303972406375875 0.0923418877747253 GO:0008081 phosphoric diester hydrolase activity 13/1193 87/18639 0.149425287356322 2.33456658091742 0.00347142885086217 0.10248915829361 GO:0005548 phospholipid transporter activity 11/1193 68/18639 0.161764705882353 2.52735318771264 0.00372641786673011 0.10248915829361 GO:0005114 type II transforming growth factor beta receptor binding 4/1193 11/18639 0.363636363636364 5.68132286824659 0.00382966605723454 0.10248915829361 GO:0008526 phosphatidylinositol transfer activity 4/1193 11/18639 0.363636363636364 5.68132286824659 0.00382966605723454 0.10248915829361 GO:0140537 transcription regulator activator activity 4/1193 11/18639 0.363636363636364 5.68132286824659 0.00382966605723454 0.10248915829361 GO:0045309 protein phosphorylated amino acid binding 10/1193 59/18639 0.169491525423729 2.64807421825053 0.00394854910340306 0.103213237028489 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 5/1193 18/18639 0.277777777777778 4.33989941324392 0.00452301046743565 0.114080501161904 GO:0031267 small GTPase binding 30/1193 283/18639 0.106007067137809 1.65621603049591 0.00461066331077319 0.114080501161904 GO:0019210 kinase inhibitor activity 13/1193 90/18639 0.144444444444444 2.25674769488684 0.00467307112732087 0.114080501161904 GO:0005543 phospholipid binding 47/1193 497/18639 0.0945674044265594 1.47748688273817 0.00477027006637856 0.114080501161904 GO:0120014 phospholipid transfer activity 6/1193 26/18639 0.230769230769231 3.60545489715649 0.00515854297399441 0.120795881307702 GO:0017166 vinculin binding 4/1193 12/18639 0.333333333333333 5.20787929589271 0.00545594869784217 0.122649726727492 GO:0097371 MDM2/MDM4 family protein binding 4/1193 12/18639 0.333333333333333 5.20787929589271 0.00545594869784217 0.122649726727492 GO:0015297 antiporter activity 17/1193 135/18639 0.125925925925926 1.96742106733724 0.00568918198746509 0.125385108900211 GO:0001540 amyloid-beta binding 12/1193 83/18639 0.144578313253012 2.25883921267635 0.0063876916137372 0.138072411035396 GO:0017124 SH3 domain binding 15/1193 115/18639 0.130434782608696 2.03786581143628 0.00657839801874225 0.13951168628427 GO:0055106 ubiquitin-protein transferase regulator activity 7/1193 36/18639 0.194444444444444 3.03792958927075 0.00702021541575774 0.146124483839106 GO:0045159 myosin II binding 4/1193 13/18639 0.307692307692308 4.80727319620865 0.00748591356510767 0.152984851766928 GO:0030291 protein serine/threonine kinase inhibitor activity 8/1193 46/18639 0.173913043478261 2.71715441524837 0.00814390636579974 0.163459834913552 GO:0035173 histone kinase activity 35/1193 360/18639 0.0972222222222222 1.51896479463537 0.00907834692110618 0.179018630514445 GO:0000146 microfilament motor activity 7/1193 38/18639 0.184210526315789 2.8780385582565 0.00949828438520344 0.182996245869668 GO:0042277 peptide binding 26/1193 249/18639 0.104417670682731 1.63138387582181 0.00960567482767828 0.182996245869668 GO:0004065 arylsulfatase activity 4/1193 14/18639 0.285714285714286 4.46389653933661 0.00995640892684183 0.183459075963446 GO:0005344 oxygen carrier activity 4/1193 14/18639 0.285714285714286 4.46389653933661 0.00995640892684183 0.183459075963446 GO:0019903 protein phosphatase binding 17/1193 144/18639 0.118055555555556 1.84445725062867 0.0106780104129748 0.193581995228768 GO:0140375 immune receptor activity 18/1193 156/18639 0.115384615384615 1.80272744857824 0.011010595295232 0.19644300177525 GO:0008093 cytoskeletal anchor activity 5/1193 22/18639 0.227272727272727 3.55082679265412 0.0112359283910753 0.19733099236826 GO:0051020 GTPase binding 31/1193 315/18639 0.0984126984126984 1.53756436354928 0.011465620741539 0.198267041745997 GO:0141003 histone H2AX kinase activity 34/1193 354/18639 0.096045197740113 1.50057539034197 0.0119030552052734 0.202712637132231 GO:0031386 protein tag activity 4/1193 15/18639 0.266666666666667 4.16630343671417 0.0128999491332153 0.213228570966676 GO:0141047 molecular tag activity 4/1193 15/18639 0.266666666666667 4.16630343671417 0.0128999491332153 0.213228570966676 GO:0140996 histone H3 kinase activity 34/1193 357/18639 0.0952380952380952 1.4879655131122 0.0133889890706574 0.217132298135484 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/1193 23/18639 0.217391304347826 3.39644301906046 0.013616408694795 0.217132298135484 GO:0140297 DNA-binding transcription factor binding 44/1193 488/18639 0.0901639344262295 1.40868866200377 0.0137156522843588 0.217132298135484 GO:0005178 integrin binding 18/1193 161/18639 0.111801242236025 1.74674212408824 0.0149081793445269 0.232546653835346 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/1193 24/18639 0.208333333333333 3.25492455993294 0.0163141481799697 0.232546653835346 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/1193 24/18639 0.208333333333333 3.25492455993294 0.0163141481799697 0.232546653835346 GO:0015149 hexose transmembrane transporter activity 5/1193 24/18639 0.208333333333333 3.25492455993294 0.0163141481799697 0.232546653835346 GO:0030215 semaphorin receptor binding 5/1193 24/18639 0.208333333333333 3.25492455993294 0.0163141481799697 0.232546653835346 GO:0030552 cAMP binding 5/1193 24/18639 0.208333333333333 3.25492455993294 0.0163141481799697 0.232546653835346 GO:0055056 D-glucose transmembrane transporter activity 5/1193 24/18639 0.208333333333333 3.25492455993294 0.0163141481799697 0.232546653835346 GO:0015385 sodium:proton antiporter activity 4/1193 16/18639 0.25 3.90590947191953 0.0163444712215234 0.232546653835346 GO:1901505 carbohydrate derivative transmembrane transporter activity 8/1193 53/18639 0.150943396226415 2.35828496417783 0.018683224122198 0.262499298916881 GO:0004709 MAP kinase kinase kinase activity 5/1193 25/18639 0.2 3.12472757753562 0.0193448334987861 0.263297992159752 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 6/1193 34/18639 0.176470588235294 2.75711256841379 0.0195059336322327 0.263297992159752 GO:0001217 DNA-binding transcription repressor activity 27/1193 278/18639 0.0971223021582734 1.51740367973852 0.0203104282110239 0.263297992159752 GO:0008484 sulfuric ester hydrolase activity 4/1193 17/18639 0.235294117647059 3.67615009121838 0.0203132144604506 0.263297992159752 GO:0001223 transcription coactivator binding 7/1193 44/18639 0.159090909090909 2.48557875485788 0.0207084284637212 0.263297992159752 GO:0003725 double-stranded RNA binding 10/1193 75/18639 0.133333333333333 2.08315171835708 0.0208118894125933 0.263297992159752 GO:0005154 epidermal growth factor receptor binding 6/1193 35/18639 0.171428571428571 2.67833792360196 0.0223047026573282 0.263297992159752 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/1193 10/18639 0.3 4.68709136630344 0.0223441919727357 0.263297992159752 GO:0005131 growth hormone receptor binding 3/1193 10/18639 0.3 4.68709136630344 0.0223441919727357 0.263297992159752 GO:0008239 dipeptidyl-peptidase activity 3/1193 10/18639 0.3 4.68709136630344 0.0223441919727357 0.263297992159752 GO:0016427 tRNA (cytidine) methyltransferase activity 3/1193 10/18639 0.3 4.68709136630344 0.0223441919727357 0.263297992159752 GO:0050308 sugar-phosphatase activity 3/1193 10/18639 0.3 4.68709136630344 0.0223441919727357 0.263297992159752 GO:0017022 myosin binding 10/1193 76/18639 0.131578947368421 2.05574182732607 0.0226391254775529 0.263297992159752 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/1193 26/18639 0.192307692307692 3.00454574763041 0.0227225217189746 0.263297992159752 GO:0005160 transforming growth factor beta receptor binding 5/1193 26/18639 0.192307692307692 3.00454574763041 0.0227225217189746 0.263297992159752 GO:0015145 monosaccharide transmembrane transporter activity 5/1193 26/18639 0.192307692307692 3.00454574763041 0.0227225217189746 0.263297992159752 GO:0051139 metal cation:proton antiporter activity 5/1193 26/18639 0.192307692307692 3.00454574763041 0.0227225217189746 0.263297992159752 GO:0140313 molecular sequestering activity 8/1193 55/18639 0.145454545454545 2.27252914729864 0.0229565865050318 0.263297992159752 GO:0008514 organic anion transmembrane transporter activity 26/1193 269/18639 0.0966542750929368 1.51009139434807 0.0236855322289133 0.268914527528268 GO:0140658 ATP-dependent chromatin remodeler activity 17/1193 158/18639 0.107594936708861 1.68102432968689 0.0246903137641107 0.273558473320901 GO:0004706 JUN kinase kinase kinase activity 4/1193 18/18639 0.222222222222222 3.47191953059514 0.0248247013155978 0.273558473320901 GO:1901611 phosphatidylglycerol binding 4/1193 18/18639 0.222222222222222 3.47191953059514 0.0248247013155978 0.273558473320901 GO:0030276 clathrin binding 7/1193 46/18639 0.152173913043478 2.37751011334232 0.0259165930655703 0.282817967045641 GO:0004683 calcium/calmodulin-dependent protein kinase activity 5/1193 27/18639 0.185185185185185 2.89326627549595 0.0264595521623998 0.283243206005118 GO:0015252 proton channel activity 5/1193 27/18639 0.185185185185185 2.89326627549595 0.0264595521623998 0.283243206005118 GO:0004679 AMP-activated protein kinase activity 24/1193 248/18639 0.0967741935483871 1.51196495687208 0.0284963563433891 0.28876091623455 GO:0046332 SMAD binding 10/1193 79/18639 0.126582278481013 1.97767568198457 0.0288146256633716 0.28876091623455 GO:0005536 D-glucose binding 3/1193 11/18639 0.272727272727273 4.26099215118494 0.0292871391910486 0.28876091623455 GO:0015173 aromatic amino acid transmembrane transporter activity 3/1193 11/18639 0.272727272727273 4.26099215118494 0.0292871391910486 0.28876091623455 GO:0019203 carbohydrate phosphatase activity 3/1193 11/18639 0.272727272727273 4.26099215118494 0.0292871391910486 0.28876091623455 GO:0019864 IgG binding 3/1193 11/18639 0.272727272727273 4.26099215118494 0.0292871391910486 0.28876091623455 GO:0034713 type I transforming growth factor beta receptor binding 3/1193 11/18639 0.272727272727273 4.26099215118494 0.0292871391910486 0.28876091623455 GO:0047676 arachidonate-CoA ligase activity 3/1193 11/18639 0.272727272727273 4.26099215118494 0.0292871391910486 0.28876091623455 GO:0048407 platelet-derived growth factor binding 3/1193 11/18639 0.272727272727273 4.26099215118494 0.0292871391910486 0.28876091623455 GO:0140104 molecular carrier activity 24/1193 249/18639 0.0963855421686747 1.5058928084509 0.029698578594793 0.290271324700412 GO:0051119 sugar transmembrane transporter activity 5/1193 28/18639 0.178571428571429 2.78993533708538 0.0305664829364877 0.296178679488036 GO:0043531 ADP binding 6/1193 38/18639 0.157894736842105 2.46689019279128 0.0322825501122782 0.310133216463254 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/1193 60/18639 0.133333333333333 2.08315171835708 0.0365445665247922 0.314707907915946 GO:0004000 adenosine deaminase activity 3/1193 12/18639 0.25 3.90590947191953 0.0372308693554508 0.314707907915946 GO:0008603 cAMP-dependent protein kinase regulator activity 3/1193 12/18639 0.25 3.90590947191953 0.0372308693554508 0.314707907915946 GO:0015368 calcium:monoatomic cation antiporter activity 3/1193 12/18639 0.25 3.90590947191953 0.0372308693554508 0.314707907915946 GO:0016840 carbon-nitrogen lyase activity 3/1193 12/18639 0.25 3.90590947191953 0.0372308693554508 0.314707907915946 GO:0019887 protein kinase regulator activity 24/1193 255/18639 0.0941176470588235 1.47046003648735 0.0377368196045026 0.314707907915946 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 25/1193 268/18639 0.0932835820895522 1.45742890743266 0.0378007896788498 0.314707907915946 GO:0015605 organophosphate ester transmembrane transporter activity 7/1193 50/18639 0.14 2.18730930427494 0.0388641295653791 0.314707907915946 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 23/1193 243/18639 0.0946502057613169 1.47878054080904 0.0391009472459181 0.314707907915946 GO:0051721 protein phosphatase 2A binding 5/1193 30/18639 0.166666666666667 2.60393964794635 0.0399231502421377 0.314707907915946 GO:0015144 carbohydrate transmembrane transporter activity 6/1193 40/18639 0.15 2.34354568315172 0.0403254626606584 0.314707907915946 GO:0071949 FAD binding 6/1193 40/18639 0.15 2.34354568315172 0.0403254626606584 0.314707907915946 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 31/1193 349/18639 0.0888252148997135 1.38777299288831 0.0405983199680653 0.314707907915946 GO:0004527 exonuclease activity 10/1193 84/18639 0.119047619047619 1.85995689139025 0.0416114434201858 0.314707907915946 GO:0009931 calcium-dependent protein serine/threonine kinase activity 4/1193 21/18639 0.19047619047619 2.9759310262244 0.041731884987845 0.314707907915946 GO:0019200 carbohydrate kinase activity 4/1193 21/18639 0.19047619047619 2.9759310262244 0.041731884987845 0.314707907915946 GO:0035091 phosphatidylinositol binding 26/1193 284/18639 0.0915492957746479 1.43033304605504 0.0421289992233385 0.314707907915946 GO:0004676 3-phosphoinositide-dependent protein kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0004711 ribosomal protein S6 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0035175 histone H3S10 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0035979 histone H2AXS139 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0044022 histone H3S28 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0044023 histone H4S1 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0044024 histone H2AS1 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0044025 histone H2BS14 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0072354 histone H3T3 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0072371 histone H2AS121 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0072518 Rho-dependent protein serine/threonine kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0140823 histone H2BS36 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0140855 histone H3S57 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0140995 histone H2A kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0140997 histone H4 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0140998 histone H2B kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:1990244 histone H2AT120 kinase activity 23/1193 245/18639 0.0938775510204082 1.46670886292489 0.0422783755296333 0.314707907915946 GO:0004677 DNA-dependent protein kinase activity 23/1193 246/18639 0.0934959349593496 1.46074663177478 0.0439363125092473 0.322773955950287 GO:0140857 histone H3T45 kinase activity 23/1193 246/18639 0.0934959349593496 1.46074663177478 0.0439363125092473 0.322773955950287 GO:0016791 phosphatase activity 25/1193 273/18639 0.0915750915750916 1.43073607030019 0.0454448724532194 0.326273561308368 GO:0033218 amide binding 23/1193 247/18639 0.0931174089068826 1.45483267779999 0.0456412612949782 0.326273561308368 GO:0035402 histone H3T11 kinase activity 23/1193 247/18639 0.0931174089068826 1.45483267779999 0.0456412612949782 0.326273561308368 GO:0035403 histone H3T6 kinase activity 23/1193 247/18639 0.0931174089068826 1.45483267779999 0.0456412612949782 0.326273561308368 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/1193 13/18639 0.230769230769231 3.60545489715649 0.0461543560925538 0.326273561308368 GO:0089720 caspase binding 3/1193 13/18639 0.230769230769231 3.60545489715649 0.0461543560925538 0.326273561308368 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 10/1193 86/18639 0.116279069767442 1.81670207996257 0.0476722136865477 0.334897301147997 GO:0008307 structural constituent of muscle 6/1193 42/18639 0.142857142857143 2.2319482696683 0.0495321710216823 0.345152643033329 GO:0031625 ubiquitin protein ligase binding 27/1193 302/18639 0.0894039735099338 1.39681530783877 0.0497461994407467 0.345152643033329 GO:1902936 phosphatidylinositol bisphosphate binding 12/1193 111/18639 0.108108108108108 1.68904193380304 0.051590576066174 0.355753420235457 GO:0005200 structural constituent of cytoskeleton 12/1193 112/18639 0.107142857142857 1.67396120225123 0.0545730954177557 0.365403438803742 GO:0019843 rRNA binding 8/1193 65/18639 0.123076923076923 1.92290927848346 0.0547080365753928 0.365403438803742 GO:0016530 metallochaperone activity 3/1193 14/18639 0.214285714285714 3.34792240450245 0.0560265235013842 0.365403438803742 GO:0019763 immunoglobulin receptor activity 3/1193 14/18639 0.214285714285714 3.34792240450245 0.0560265235013842 0.365403438803742 GO:0019992 diacylglycerol binding 3/1193 14/18639 0.214285714285714 3.34792240450245 0.0560265235013842 0.365403438803742 GO:0031404 chloride ion binding 3/1193 14/18639 0.214285714285714 3.34792240450245 0.0560265235013842 0.365403438803742 GO:0032036 myosin heavy chain binding 3/1193 14/18639 0.214285714285714 3.34792240450245 0.0560265235013842 0.365403438803742 GO:0034236 protein kinase A catalytic subunit binding 3/1193 14/18639 0.214285714285714 3.34792240450245 0.0560265235013842 0.365403438803742 GO:0046030 inositol trisphosphate phosphatase activity 3/1193 14/18639 0.214285714285714 3.34792240450245 0.0560265235013842 0.365403438803742 GO:0003724 RNA helicase activity 9/1193 77/18639 0.116883116883117 1.82613949336498 0.0568341940177012 0.365403438803742 GO:0019239 deaminase activity 5/1193 33/18639 0.151515151515152 2.36721786176941 0.0568911047959563 0.365403438803742 GO:0140311 protein sequestering activity 5/1193 33/18639 0.151515151515152 2.36721786176941 0.0568911047959563 0.365403438803742 GO:0000510 H3-H4 histone complex chaperone activity 15/1193 151/18639 0.0993377483443709 1.55201700870975 0.0599873257558406 0.376680190779692 GO:0140584 chromatin extrusion motor activity 15/1193 151/18639 0.0993377483443709 1.55201700870975 0.0599873257558406 0.376680190779692 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 15/1193 151/18639 0.0993377483443709 1.55201700870975 0.0599873257558406 0.376680190779692 GO:0140849 ATP-dependent H2AZ histone chaperone activity 15/1193 151/18639 0.0993377483443709 1.55201700870975 0.0599873257558406 0.376680190779692 GO:0015081 sodium ion transmembrane transporter activity 16/1193 164/18639 0.0975609756097561 1.52425735489543 0.0609175259803155 0.380396106677081 GO:0044389 ubiquitin-like protein ligase binding 28/1193 322/18639 0.0869565217391304 1.35857720762418 0.0615342349513536 0.382124199366417 GO:0015616 DNA translocase activity 15/1193 152/18639 0.0986842105263158 1.54180637049455 0.0628076817440085 0.383124386801079 GO:0140674 ATP-dependent histone chaperone activity 15/1193 152/18639 0.0986842105263158 1.54180637049455 0.0628076817440085 0.383124386801079 GO:0042826 histone deacetylase binding 13/1193 127/18639 0.102362204724409 1.59927001999855 0.0630259538685617 0.383124386801079 GO:0048027 mRNA 5'-UTR binding 4/1193 24/18639 0.166666666666667 2.60393964794635 0.0637625983143408 0.383124386801079 GO:0035401 histone H3Y41 kinase activity 12/1193 115/18639 0.104347826086957 1.63029264914902 0.0642095486493177 0.383124386801079 GO:0140801 histone H2AXY142 kinase activity 12/1193 115/18639 0.104347826086957 1.63029264914902 0.0642095486493177 0.383124386801079 GO:0008186 ATP-dependent activity, acting on RNA 9/1193 79/18639 0.113924050632911 1.77990811378612 0.064881870416597 0.383124386801079 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/1193 45/18639 0.133333333333333 2.08315171835708 0.065577852757163 0.383124386801079 GO:0042605 peptide antigen binding 6/1193 45/18639 0.133333333333333 2.08315171835708 0.065577852757163 0.383124386801079 GO:0140303 intramembrane lipid transporter activity 6/1193 45/18639 0.133333333333333 2.08315171835708 0.065577852757163 0.383124386801079 GO:0061775 cohesin loader activity 15/1193 153/18639 0.0980392156862745 1.53172920467433 0.065716214552993 0.383124386801079 GO:0004129 cytochrome-c oxidase activity 3/1193 15/18639 0.2 3.12472757753562 0.0668081670934266 0.383124386801079 GO:0004467 long-chain fatty acid-CoA ligase activity 3/1193 15/18639 0.2 3.12472757753562 0.0668081670934266 0.383124386801079 GO:0061578 K63-linked deubiquitinase activity 3/1193 15/18639 0.2 3.12472757753562 0.0668081670934266 0.383124386801079 GO:0120283 protein serine/threonine kinase binding 3/1193 15/18639 0.2 3.12472757753562 0.0668081670934266 0.383124386801079 GO:0030145 manganese ion binding 8/1193 68/18639 0.117647058823529 1.83807504560919 0.0679566336802409 0.387732265261882 GO:0035591 signaling adaptor activity 13/1193 129/18639 0.10077519379845 1.57447513596756 0.0695674688496263 0.3944417046115 GO:0000175 3'-5'-RNA exonuclease activity 5/1193 35/18639 0.142857142857143 2.2319482696683 0.0701755108462467 0.3944417046115 GO:0015932 nucleobase-containing compound transmembrane transporter activity 7/1193 57/18639 0.12280701754386 1.918692372171 0.070382122985023 0.3944417046115 GO:0046873 metal ion transmembrane transporter activity 37/1193 450/18639 0.0822222222222222 1.2846102263202 0.0705362834758999 0.3944417046115 GO:0015271 outward rectifier potassium channel activity 4/1193 25/18639 0.16 2.4997820620285 0.072223124945875 0.400972402980488 GO:0019207 kinase regulator activity 25/1193 287/18639 0.0871080139372822 1.36094406687092 0.0727625773439774 0.400972402980488 GO:0002039 p53 binding 8/1193 69/18639 0.115942028985507 1.81143627683225 0.0727743507188786 0.400972402980488 GO:0015101 organic cation transmembrane transporter activity 9/1193 81/18639 0.111111111111111 1.73595976529757 0.0736145445721375 0.403623161458939 GO:0004707 MAP kinase activity 3/1193 16/18639 0.1875 2.92943210393965 0.078453635371558 0.419913743607767 GO:0004708 MAP kinase kinase activity 3/1193 16/18639 0.1875 2.92943210393965 0.078453635371558 0.419913743607767 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/1193 16/18639 0.1875 2.92943210393965 0.078453635371558 0.419913743607767 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/1193 16/18639 0.1875 2.92943210393965 0.078453635371558 0.419913743607767 GO:0055102 lipase inhibitor activity 3/1193 16/18639 0.1875 2.92943210393965 0.078453635371558 0.419913743607767 GO:0003924 GTPase activity 28/1193 331/18639 0.0845921450151057 1.32163704185797 0.0803053594777633 0.42239371547854 GO:0005112 Notch binding 4/1193 26/18639 0.153846153846154 2.40363659810433 0.0812232346234933 0.42239371547854 GO:0019865 immunoglobulin binding 4/1193 26/18639 0.153846153846154 2.40363659810433 0.0812232346234933 0.42239371547854 GO:0050750 low-density lipoprotein particle receptor binding 4/1193 26/18639 0.153846153846154 2.40363659810433 0.0812232346234933 0.42239371547854 GO:0001786 phosphatidylserine binding 7/1193 59/18639 0.11864406779661 1.85365195277537 0.0815475411555544 0.42239371547854 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/1193 59/18639 0.11864406779661 1.85365195277537 0.0815475411555544 0.42239371547854 GO:0070888 E-box binding 7/1193 59/18639 0.11864406779661 1.85365195277537 0.0815475411555544 0.42239371547854 GO:0030551 cyclic nucleotide binding 5/1193 37/18639 0.135135135135135 2.1113024172538 0.0850158307304706 0.436336957721685 GO:0042805 actinin binding 5/1193 37/18639 0.135135135135135 2.1113024172538 0.0850158307304706 0.436336957721685 GO:0003689 DNA clamp loader activity 15/1193 160/18639 0.09375 1.46471605196982 0.0885996713146661 0.451393885021294 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/1193 27/18639 0.148148148148148 2.31461302039676 0.0907473533123791 0.451393885021294 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 4/1193 27/18639 0.148148148148148 2.31461302039676 0.0907473533123791 0.451393885021294 GO:0008429 phosphatidylethanolamine binding 3/1193 17/18639 0.176470588235294 2.75711256841379 0.0909122969953667 0.451393885021294 GO:0017110 nucleoside diphosphate phosphatase activity 3/1193 17/18639 0.176470588235294 2.75711256841379 0.0909122969953667 0.451393885021294 GO:0030169 low-density lipoprotein particle binding 3/1193 17/18639 0.176470588235294 2.75711256841379 0.0909122969953667 0.451393885021294 GO:0070492 oligosaccharide binding 3/1193 17/18639 0.176470588235294 2.75711256841379 0.0909122969953667 0.451393885021294 GO:0001222 transcription corepressor binding 6/1193 49/18639 0.122448979591837 1.91309851685855 0.0911622881671119 0.451393885021294 GO:0140097 catalytic activity, acting on DNA 28/1193 336/18639 0.0833333333333333 1.30196982397318 0.0922641454269519 0.454846050262693 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 5/1193 38/18639 0.131578947368421 2.05574182732607 0.093005721733227 0.456499699686232 GO:0050660 flavin adenine dinucleotide binding 9/1193 86/18639 0.104651162790698 1.63503187196632 0.0984688477562358 0.481212977730474 GO:0045499 chemorepellent activity 4/1193 28/18639 0.142857142857143 2.2319482696683 0.100777498375028 0.488249604196254 GO:0051019 mitogen-activated protein kinase binding 4/1193 28/18639 0.142857142857143 2.2319482696683 0.100777498375028 0.488249604196254 GO:0140713 histone chaperone activity 15/1193 164/18639 0.0914634146341463 1.42899127021446 0.103695251043823 0.498050695028103 GO:0008409 5'-3' exonuclease activity 3/1193 18/18639 0.166666666666667 2.60393964794635 0.10412981613132 0.498050695028103 GO:0008525 phosphatidylcholine transporter activity 3/1193 18/18639 0.166666666666667 2.60393964794635 0.10412981613132 0.498050695028103 GO:0005048 signal sequence binding 6/1193 51/18639 0.117647058823529 1.83807504560919 0.105711834242831 0.503475007156535 GO:0004532 RNA exonuclease activity 5/1193 40/18639 0.125 1.95295473595977 0.110085243179333 0.522092039382152 GO:0043236 laminin binding 4/1193 29/18639 0.137931034482759 2.15498453623146 0.111293570039916 0.523405743618685 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/1193 29/18639 0.137931034482759 2.15498453623146 0.111293570039916 0.523405743618685 GO:0004713 protein tyrosine kinase activity 13/1193 140/18639 0.0928571428571429 1.4507663752844 0.113303363311479 0.530637418175426 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 9/1193 89/18639 0.101123595505618 1.57991843807981 0.115438724482631 0.536169943464782 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 9/1193 89/18639 0.101123595505618 1.57991843807981 0.115438724482631 0.536169943464782 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1193 19/18639 0.157894736842105 2.46689019279128 0.118049256444202 0.539379529444239 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/1193 19/18639 0.157894736842105 2.46689019279128 0.118049256444202 0.539379529444239 GO:0022840 leak channel activity 3/1193 19/18639 0.157894736842105 2.46689019279128 0.118049256444202 0.539379529444239 GO:0022842 narrow pore channel activity 3/1193 19/18639 0.157894736842105 2.46689019279128 0.118049256444202 0.539379529444239 GO:0120013 lipid transfer activity 7/1193 65/18639 0.107692307692308 1.68254561867303 0.120742332227173 0.541099163824565 GO:0140793 histone H2AXY142 phosphatase activity 9/1193 90/18639 0.1 1.56236378876781 0.121431193311729 0.541099163824565 GO:0001965 G-protein alpha-subunit binding 4/1193 30/18639 0.133333333333333 2.08315171835708 0.12227363462419 0.541099163824565 GO:0001968 fibronectin binding 4/1193 30/18639 0.133333333333333 2.08315171835708 0.12227363462419 0.541099163824565 GO:0031210 phosphatidylcholine binding 4/1193 30/18639 0.133333333333333 2.08315171835708 0.12227363462419 0.541099163824565 GO:0098918 structural constituent of synapse 4/1193 30/18639 0.133333333333333 2.08315171835708 0.12227363462419 0.541099163824565 GO:0015294 solute:monoatomic cation symporter activity 11/1193 116/18639 0.0948275862068965 1.48155186865913 0.123503152832469 0.541099163824565 GO:0004175 endopeptidase activity 32/1193 405/18639 0.0790123456790123 1.23446027754494 0.127547542061241 0.541099163824565 GO:0072341 modified amino acid binding 9/1193 91/18639 0.0989010989010989 1.54519495592421 0.127588470812425 0.541099163824565 GO:0035198 miRNA binding 5/1193 42/18639 0.119047619047619 1.85995689139025 0.128563753242398 0.541099163824565 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 6/1193 54/18639 0.111111111111111 1.73595976529757 0.129627565549852 0.541099163824565 GO:0005337 nucleoside transmembrane transporter activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0005345 purine nucleobase transmembrane transporter activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0005381 iron ion transmembrane transporter activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0005528 FK506 binding 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0015279 store-operated calcium channel activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0030957 Tat protein binding 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0031434 mitogen-activated protein kinase kinase binding 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0032395 MHC class II receptor activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0070513 death domain binding 2/1193 10/18639 0.2 3.12472757753562 0.130942146405945 0.541099163824565 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/1193 20/18639 0.15 2.34354568315172 0.132612032233729 0.543999723469749 GO:0052745 inositol phosphate phosphatase activity 3/1193 20/18639 0.15 2.34354568315172 0.132612032233729 0.543999723469749 GO:0070325 lipoprotein particle receptor binding 4/1193 31/18639 0.129032258064516 2.01595327582943 0.133694197258641 0.546444646249862 GO:0005245 voltage-gated calcium channel activity 5/1193 43/18639 0.116279069767442 1.81670207996257 0.138298351174722 0.56321502434923 GO:0016829 lyase activity 17/1193 200/18639 0.085 1.32800922045264 0.14202465734352 0.576302219689952 GO:0043425 bHLH transcription factor binding 4/1193 32/18639 0.125 1.95295473595977 0.145530462375822 0.586279148341616 GO:0070717 poly-purine tract binding 4/1193 32/18639 0.125 1.95295473595977 0.145530462375822 0.586279148341616 GO:0001618 virus receptor activity 8/1193 81/18639 0.0987654320987654 1.54307534693117 0.14604818641962 0.586279148341616 GO:0015085 calcium ion transmembrane transporter activity 13/1193 147/18639 0.0884353741496599 1.38168226217562 0.14795670451142 0.58697324613062 GO:0140597 protein carrier chaperone 16/1193 188/18639 0.0851063829787234 1.32967130958963 0.149630153199964 0.58697324613062 GO:0019209 kinase activator activity 13/1193 148/18639 0.0878378378378378 1.37234657121497 0.153324602207447 0.58697324613062 GO:0140272 exogenous protein binding 8/1193 82/18639 0.0975609756097561 1.52425735489543 0.153378832253521 0.58697324613062 GO:0008046 axon guidance receptor activity 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0008172 S-methyltransferase activity 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0015205 nucleobase transmembrane transporter activity 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0032794 GTPase activating protein binding 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0035252 UDP-xylosyltransferase activity 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0042285 xylosyltransferase activity 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0050786 RAGE receptor binding 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0140031 phosphorylation-dependent protein binding 2/1193 11/18639 0.181818181818182 2.84066143412329 0.153532148009255 0.58697324613062 GO:0004601 peroxidase activity 6/1193 57/18639 0.105263157894737 1.64459346186086 0.155887855198892 0.593959149978151 GO:0019956 chemokine binding 4/1193 33/18639 0.121212121212121 1.89377428941553 0.1577565806627 0.595767636978673 GO:0140416 transcription regulator inhibitor activity 4/1193 33/18639 0.121212121212121 1.89377428941553 0.1577565806627 0.595767636978673 GO:0008528 G protein-coupled peptide receptor activity 11/1193 122/18639 0.0901639344262295 1.40868866200377 0.15795262973278 0.595767636978673 GO:0097110 scaffold protein binding 7/1193 70/18639 0.1 1.56236378876781 0.159543153796824 0.599754196881707 GO:0044325 transmembrane transporter binding 12/1193 136/18639 0.0882352941176471 1.37855628420689 0.161587405761648 0.605414146920308 GO:0015377 chloride:monoatomic cation symporter activity 3/1193 22/18639 0.136363636363636 2.13049607559247 0.163429769632398 0.610282594906362 GO:0008408 3'-5' exonuclease activity 6/1193 58/18639 0.103448275862069 1.6162384021736 0.1651236678455 0.612537962568784 GO:0061980 regulatory RNA binding 6/1193 58/18639 0.103448275862069 1.6162384021736 0.1651236678455 0.612537962568784 GO:0005126 cytokine receptor binding 22/1193 275/18639 0.08 1.24989103101425 0.16567108384728 0.612547033698498 GO:0005319 lipid transporter activity 15/1193 178/18639 0.0842696629213483 1.31659869839984 0.167998917134688 0.619117320850457 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/1193 34/18639 0.117647058823529 1.83807504560919 0.170345881556112 0.623676778075145 GO:0019825 oxygen binding 4/1193 34/18639 0.117647058823529 1.83807504560919 0.170345881556112 0.623676778075145 GO:0004879 nuclear receptor activity 6/1193 59/18639 0.101694915254237 1.58884453095032 0.174585116150022 0.628843866467649 GO:0031593 polyubiquitin modification-dependent protein binding 6/1193 59/18639 0.101694915254237 1.58884453095032 0.174585116150022 0.628843866467649 GO:0004725 protein tyrosine phosphatase activity 9/1193 98/18639 0.0918367346938776 1.43482388764391 0.175082539552926 0.628843866467649 GO:0004859 phospholipase inhibitor activity 2/1193 12/18639 0.166666666666667 2.60393964794635 0.176792403740015 0.628843866467649 GO:0004875 complement receptor activity 2/1193 12/18639 0.166666666666667 2.60393964794635 0.176792403740015 0.628843866467649 GO:0005527 macrolide binding 2/1193 12/18639 0.166666666666667 2.60393964794635 0.176792403740015 0.628843866467649 GO:0015132 prostaglandin transmembrane transporter activity 2/1193 12/18639 0.166666666666667 2.60393964794635 0.176792403740015 0.628843866467649 GO:0034452 dynactin binding 2/1193 12/18639 0.166666666666667 2.60393964794635 0.176792403740015 0.628843866467649 GO:0035259 nuclear glucocorticoid receptor binding 2/1193 12/18639 0.166666666666667 2.60393964794635 0.176792403740015 0.628843866467649 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1193 23/18639 0.130434782608696 2.03786581143628 0.179566056583466 0.63289800440233 GO:0099186 structural constituent of postsynapse 3/1193 23/18639 0.130434782608696 2.03786581143628 0.179566056583466 0.63289800440233 GO:0030295 protein kinase activator activity 12/1193 139/18639 0.0863309352517986 1.34880327087869 0.179621408722725 0.63289800440233 GO:0016874 ligase activity 14/1193 167/18639 0.0838323353293413 1.30976605046403 0.183060227849396 0.642821972656083 GO:0098531 ligand-modulated transcription factor activity 6/1193 60/18639 0.1 1.56236378876781 0.184262203471387 0.642821972656083 GO:0016209 antioxidant activity 8/1193 86/18639 0.0930232558139535 1.45336166397006 0.184377975035341 0.642821972656083 GO:0004518 nuclease activity 17/1193 209/18639 0.0813397129186603 1.27082222052884 0.18472553128818 0.642821972656083 GO:0008094 ATP-dependent activity, acting on DNA 17/1193 210/18639 0.080952380952381 1.26477068614537 0.189830373331585 0.652351628781721 GO:0003684 damaged DNA binding 7/1193 74/18639 0.0945945945945946 1.47791169207766 0.194127814629786 0.652351628781721 GO:0048029 monosaccharide binding 7/1193 74/18639 0.0945945945945946 1.47791169207766 0.194127814629786 0.652351628781721 GO:0015026 coreceptor activity 6/1193 61/18639 0.0983606557377049 1.53675126764047 0.194144557606889 0.652351628781721 GO:0016836 hydro-lyase activity 6/1193 61/18639 0.0983606557377049 1.53675126764047 0.194144557606889 0.652351628781721 GO:0035035 histone acetyltransferase binding 3/1193 24/18639 0.125 1.95295473595977 0.196109407764769 0.652351628781721 GO:0070300 phosphatidic acid binding 3/1193 24/18639 0.125 1.95295473595977 0.196109407764769 0.652351628781721 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/1193 36/18639 0.111111111111111 1.73595976529757 0.196504531894248 0.652351628781721 GO:0001653 peptide receptor activity 11/1193 128/18639 0.0859375 1.34265638097234 0.196690738111697 0.652351628781721 GO:0002161 aminoacyl-tRNA editing activity 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0008035 high-density lipoprotein particle binding 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0008253 5'-nucleotidase activity 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0019855 calcium channel inhibitor activity 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0031994 insulin-like growth factor I binding 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0032396 inhibitory MHC class I receptor activity 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0043560 insulin receptor substrate binding 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0051011 microtubule minus-end binding 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0061459 L-arginine transmembrane transporter activity 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0071714 icosanoid transmembrane transporter activity 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0140333 glycerophospholipid flippase activity 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1193 13/18639 0.153846153846154 2.40363659810433 0.200544776039554 0.652351628781721 GO:0061135 endopeptidase regulator activity 15/1193 184/18639 0.0815217391304348 1.27366613214767 0.200684704732692 0.652351628781721 GO:0004197 cysteine-type endopeptidase activity 8/1193 88/18639 0.0909090909090909 1.42033071706165 0.200812867934587 0.652351628781721 GO:0015179 L-amino acid transmembrane transporter activity 6/1193 62/18639 0.0967741935483871 1.51196495687208 0.204221477761104 0.661440526506247 GO:0008238 exopeptidase activity 9/1193 102/18639 0.0882352941176471 1.37855628420689 0.205376106539751 0.661440526506247 GO:0015171 amino acid transmembrane transporter activity 9/1193 102/18639 0.0882352941176471 1.37855628420689 0.205376106539751 0.661440526506247 GO:1901981 phosphatidylinositol phosphate binding 15/1193 185/18639 0.0810810810810811 1.26678145035228 0.20640301174644 0.662848529151424 GO:0023023 MHC protein complex binding 4/1193 37/18639 0.108108108108108 1.68904193380304 0.210018313853494 0.672515063952059 GO:0008483 transaminase activity 3/1193 25/18639 0.12 1.87483654652137 0.213002991785528 0.672515063952059 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/1193 25/18639 0.12 1.87483654652137 0.213002991785528 0.672515063952059 GO:0015645 fatty acid ligase activity 3/1193 25/18639 0.12 1.87483654652137 0.213002991785528 0.672515063952059 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/1193 25/18639 0.12 1.87483654652137 0.213002991785528 0.672515063952059 GO:0120515 fatty acid-CoA ligase activity 3/1193 25/18639 0.12 1.87483654652137 0.213002991785528 0.672515063952059 GO:0005507 copper ion binding 6/1193 63/18639 0.0952380952380952 1.4879655131122 0.214481980771214 0.673401526220237 GO:1901682 sulfur compound transmembrane transporter activity 6/1193 63/18639 0.0952380952380952 1.4879655131122 0.214481980771214 0.673401526220237 GO:0004705 JUN kinase activity 2/1193 14/18639 0.142857142857143 2.2319482696683 0.224631151462582 0.693324984535898 GO:0005161 platelet-derived growth factor receptor binding 2/1193 14/18639 0.142857142857143 2.2319482696683 0.224631151462582 0.693324984535898 GO:0005347 ATP transmembrane transporter activity 2/1193 14/18639 0.142857142857143 2.2319482696683 0.224631151462582 0.693324984535898 GO:0015386 potassium:proton antiporter activity 2/1193 14/18639 0.142857142857143 2.2319482696683 0.224631151462582 0.693324984535898 GO:0030983 mismatched DNA binding 2/1193 14/18639 0.142857142857143 2.2319482696683 0.224631151462582 0.693324984535898 GO:0004536 DNA nuclease activity 6/1193 64/18639 0.09375 1.46471605196982 0.224914846381175 0.693324984535898 GO:0015293 symporter activity 12/1193 146/18639 0.0821917808219178 1.28413462090505 0.225145568821711 0.693324984535898 GO:0004435 phosphatidylinositol phospholipase C activity 3/1193 26/18639 0.115384615384615 1.80272744857824 0.230191655763184 0.69366064632123 GO:0004529 DNA exonuclease activity 3/1193 26/18639 0.115384615384615 1.80272744857824 0.230191655763184 0.69366064632123 GO:0005227 calcium-activated cation channel activity 3/1193 26/18639 0.115384615384615 1.80272744857824 0.230191655763184 0.69366064632123 GO:0008157 protein phosphatase 1 binding 3/1193 26/18639 0.115384615384615 1.80272744857824 0.230191655763184 0.69366064632123 GO:0015216 purine nucleotide transmembrane transporter activity 3/1193 26/18639 0.115384615384615 1.80272744857824 0.230191655763184 0.69366064632123 GO:0043548 phosphatidylinositol 3-kinase binding 3/1193 26/18639 0.115384615384615 1.80272744857824 0.230191655763184 0.69366064632123 GO:0050681 nuclear androgen receptor binding 3/1193 26/18639 0.115384615384615 1.80272744857824 0.230191655763184 0.69366064632123 GO:0070412 R-SMAD binding 3/1193 26/18639 0.115384615384615 1.80272744857824 0.230191655763184 0.69366064632123 GO:0004866 endopeptidase inhibitor activity 13/1193 161/18639 0.0807453416149068 1.26153597850817 0.231674220640126 0.696261561495994 GO:0003714 transcription corepressor activity 16/1193 204/18639 0.0784313725490196 1.22538336373946 0.234620245823387 0.703235083481299 GO:0030159 signaling receptor complex adaptor activity 5/1193 52/18639 0.0961538461538462 1.5022728738152 0.2381716193269 0.711981117349564 GO:0015370 solute:sodium symporter activity 7/1193 79/18639 0.0886075949367089 1.3843729773892 0.241046522013871 0.713715944668978 GO:0008235 metalloexopeptidase activity 6/1193 66/18639 0.0909090909090909 1.42033071706165 0.246251862440392 0.713715944668978 GO:0016405 CoA-ligase activity 3/1193 27/18639 0.111111111111111 1.73595976529757 0.247622193569535 0.713715944668978 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/1193 27/18639 0.111111111111111 1.73595976529757 0.247622193569535 0.713715944668978 GO:0035255 ionotropic glutamate receptor binding 3/1193 27/18639 0.111111111111111 1.73595976529757 0.247622193569535 0.713715944668978 GO:0004089 carbonate dehydratase activity 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0004559 alpha-mannosidase activity 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0008252 nucleotidase activity 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0016846 carbon-sulfur lyase activity 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0031005 filamin binding 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0050780 dopamine receptor binding 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0051371 muscle alpha-actinin binding 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0140161 monocarboxylate:sodium symporter activity 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0140776 protein-containing complex destabilizing activity 2/1193 15/18639 0.133333333333333 2.08315171835708 0.248911610596299 0.713715944668978 GO:0005246 calcium channel regulator activity 5/1193 53/18639 0.0943396226415094 1.47392810261114 0.250336883276495 0.715976225961272 GO:0050997 quaternary ammonium group binding 4/1193 40/18639 0.1 1.56236378876781 0.25196305116581 0.718798145965407 GO:0050840 extracellular matrix binding 6/1193 67/18639 0.0895522388059701 1.39913175113535 0.257132777518161 0.731689220076995 GO:0016922 nuclear receptor binding 11/1193 137/18639 0.0802919708029197 1.25445267711284 0.261600326987 0.740951520529759 GO:0004867 serine-type endopeptidase inhibitor activity 8/1193 95/18639 0.0842105263157895 1.31567476948868 0.262456844656765 0.740951520529759 GO:0019789 SUMO transferase activity 3/1193 28/18639 0.107142857142857 1.67396120225123 0.265243556992876 0.740951520529759 GO:0046875 ephrin receptor binding 3/1193 28/18639 0.107142857142857 1.67396120225123 0.265243556992876 0.740951520529759 GO:0050698 proteoglycan sulfotransferase activity 3/1193 28/18639 0.107142857142857 1.67396120225123 0.265243556992876 0.740951520529759 GO:0051393 alpha-actinin binding 3/1193 28/18639 0.107142857142857 1.67396120225123 0.265243556992876 0.740951520529759 GO:0051959 dynein light intermediate chain binding 3/1193 28/18639 0.107142857142857 1.67396120225123 0.265243556992876 0.740951520529759 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/1193 41/18639 0.0975609756097561 1.52425735489543 0.266320653286497 0.740951520529759 GO:0140318 protein transporter activity 4/1193 41/18639 0.0975609756097561 1.52425735489543 0.266320653286497 0.740951520529759 GO:0004896 cytokine receptor activity 8/1193 96/18639 0.0833333333333333 1.30196982397318 0.271702112449453 0.745503230348228 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1193 16/18639 0.125 1.95295473595977 0.273262749914119 0.745503230348228 GO:0015923 mannosidase activity 2/1193 16/18639 0.125 1.95295473595977 0.273262749914119 0.745503230348228 GO:0022841 potassium ion leak channel activity 2/1193 16/18639 0.125 1.95295473595977 0.273262749914119 0.745503230348228 GO:0022858 alanine transmembrane transporter activity 2/1193 16/18639 0.125 1.95295473595977 0.273262749914119 0.745503230348228 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1193 16/18639 0.125 1.95295473595977 0.273262749914119 0.745503230348228 GO:0140327 flippase activity 2/1193 16/18639 0.125 1.95295473595977 0.273262749914119 0.745503230348228 GO:0140328 floppase activity 2/1193 16/18639 0.125 1.95295473595977 0.273262749914119 0.745503230348228 GO:0003774 cytoskeletal motor activity 12/1193 153/18639 0.0784313725490196 1.22538336373946 0.27477814220809 0.747822353128071 GO:0140098 catalytic activity, acting on RNA 28/1193 387/18639 0.0723514211886305 1.13039240531004 0.276758037609245 0.750050232188289 GO:0070851 growth factor receptor binding 11/1193 139/18639 0.079136690647482 1.23640299830546 0.276931357969875 0.750050232188289 GO:0061134 peptidase regulator activity 17/1193 226/18639 0.0752212389380531 1.17522939863066 0.279921464735355 0.756326265294564 GO:0048487 beta-tubulin binding 4/1193 42/18639 0.0952380952380952 1.4879655131122 0.280821379606929 0.756938203065198 GO:0004629 phospholipase C activity 3/1193 29/18639 0.103448275862069 1.6162384021736 0.283007017025909 0.757380683659814 GO:0099604 ligand-gated calcium channel activity 3/1193 29/18639 0.103448275862069 1.6162384021736 0.283007017025909 0.757380683659814 GO:0106222 lncRNA binding 3/1193 29/18639 0.103448275862069 1.6162384021736 0.283007017025909 0.757380683659814 GO:0030414 peptidase inhibitor activity 13/1193 169/18639 0.0769230769230769 1.20181829905216 0.286509733414994 0.764418298805248 GO:0030170 pyridoxal phosphate binding 5/1193 56/18639 0.0892857142857143 1.39496766854269 0.287676993233648 0.764418298805248 GO:0170055 lipid transmembrane transporter activity 5/1193 56/18639 0.0892857142857143 1.39496766854269 0.287676993233648 0.764418298805248 GO:0004386 helicase activity 12/1193 155/18639 0.0774193548387097 1.20957196549766 0.289572818802773 0.767641151731878 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/1193 70/18639 0.0857142857142857 1.33916896180098 0.290484280448745 0.768245485233857 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/1193 43/18639 0.0930232558139535 1.45336166397006 0.295439126112796 0.770681072459815 GO:0004550 nucleoside diphosphate kinase activity 2/1193 17/18639 0.117647058823529 1.83807504560919 0.297576143636619 0.770681072459815 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1193 17/18639 0.117647058823529 1.83807504560919 0.297576143636619 0.770681072459815 GO:0015278 intracellularly gated calcium channel activity 2/1193 17/18639 0.117647058823529 1.83807504560919 0.297576143636619 0.770681072459815 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1193 17/18639 0.117647058823529 1.83807504560919 0.297576143636619 0.770681072459815 GO:0016805 dipeptidase activity 2/1193 17/18639 0.117647058823529 1.83807504560919 0.297576143636619 0.770681072459815 GO:0019198 transmembrane receptor protein phosphatase activity 2/1193 17/18639 0.117647058823529 1.83807504560919 0.297576143636619 0.770681072459815 GO:0038191 neuropilin binding 2/1193 17/18639 0.117647058823529 1.83807504560919 0.297576143636619 0.770681072459815 GO:0048038 quinone binding 2/1193 17/18639 0.117647058823529 1.83807504560919 0.297576143636619 0.770681072459815 GO:0070279 vitamin B6 binding 5/1193 57/18639 0.087719298245614 1.37049455155071 0.30034902573699 0.772086074595036 GO:0015215 nucleotide transmembrane transporter activity 3/1193 30/18639 0.1 1.56236378876781 0.300866281737211 0.772086074595036 GO:0016769 transferase activity, transferring nitrogenous groups 3/1193 30/18639 0.1 1.56236378876781 0.300866281737211 0.772086074595036 GO:0022839 monoatomic ion-gated channel activity 3/1193 30/18639 0.1 1.56236378876781 0.300866281737211 0.772086074595036 GO:0000287 magnesium ion binding 17/1193 230/18639 0.0739130434782609 1.15479062648056 0.304500888684247 0.779633254854428 GO:0045296 cadherin binding 24/1193 334/18639 0.0718562874251497 1.12265661468346 0.307501850421706 0.785527454259086 GO:0016248 channel inhibitor activity 4/1193 44/18639 0.0909090909090909 1.42033071706165 0.310148469355144 0.788703347409913 GO:0019205 nucleobase-containing compound kinase activity 4/1193 44/18639 0.0909090909090909 1.42033071706165 0.310148469355144 0.788703347409913 GO:0005518 collagen binding 6/1193 72/18639 0.0833333333333333 1.30196982397318 0.313191807848557 0.794644677250063 GO:0046943 carboxylic acid transmembrane transporter activity 14/1193 188/18639 0.074468085106383 1.16346239589092 0.317906602669868 0.794845702114405 GO:0005164 tumor necrosis factor receptor binding 3/1193 31/18639 0.0967741935483871 1.51196495687208 0.318777576502773 0.794845702114405 GO:0016878 acid-thiol ligase activity 3/1193 31/18639 0.0967741935483871 1.51196495687208 0.318777576502773 0.794845702114405 GO:0004970 glutamate-gated receptor activity 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0016854 racemase and epimerase activity 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0017128 phospholipid scramblase activity 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0032393 MHC class I receptor activity 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0034185 apolipoprotein binding 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0035615 clathrin adaptor activity 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0070064 proline-rich region binding 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0070628 proteasome binding 2/1193 18/18639 0.111111111111111 1.73595976529757 0.321756934574781 0.794845702114405 GO:0043539 protein serine/threonine kinase activator activity 6/1193 73/18639 0.0821917808219178 1.28413462090505 0.324652608809264 0.79571310036149 GO:0046915 transition metal ion transmembrane transporter activity 4/1193 45/18639 0.0888888888888889 1.38876781223806 0.324924742091662 0.79571310036149 GO:0141110 transporter inhibitor activity 4/1193 45/18639 0.0888888888888889 1.38876781223806 0.324924742091662 0.79571310036149 GO:0005342 organic acid transmembrane transporter activity 14/1193 189/18639 0.0740740740740741 1.15730651019838 0.324939780307761 0.79571310036149 GO:0005262 calcium channel activity 10/1193 131/18639 0.0763358778625954 1.19264411356322 0.329076378567979 0.804090977196539 GO:0004721 phosphoprotein phosphatase activity 13/1193 175/18639 0.0742857142857143 1.16061310022752 0.32998557924535 0.804563538116644 GO:0030515 snoRNA binding 3/1193 32/18639 0.09375 1.46471605196982 0.336699691757285 0.81376032173938 GO:0051059 NF-kappaB binding 3/1193 32/18639 0.09375 1.46471605196982 0.336699691757285 0.81376032173938 GO:0071813 lipoprotein particle binding 3/1193 32/18639 0.09375 1.46471605196982 0.336699691757285 0.81376032173938 GO:0071814 protein-lipid complex binding 3/1193 32/18639 0.09375 1.46471605196982 0.336699691757285 0.81376032173938 GO:0004252 serine-type endopeptidase activity 13/1193 176/18639 0.0738636363636364 1.15401870761259 0.337377499938213 0.81376032173938 GO:0004180 carboxypeptidase activity 4/1193 46/18639 0.0869565217391304 1.35857720762418 0.339744097815807 0.81465857273307 GO:0008083 growth factor activity 12/1193 162/18639 0.0740740740740741 1.15730651019838 0.342961441510419 0.81465857273307 GO:0003727 single-stranded RNA binding 7/1193 89/18639 0.0786516853932584 1.22882545183985 0.343242655069586 0.81465857273307 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/1193 19/18639 0.105263157894737 1.64459346186086 0.345722543766614 0.81465857273307 GO:0005520 insulin-like growth factor binding 2/1193 19/18639 0.105263157894737 1.64459346186086 0.345722543766614 0.81465857273307 GO:0022821 solute:potassium antiporter activity 2/1193 19/18639 0.105263157894737 1.64459346186086 0.345722543766614 0.81465857273307 GO:0042577 lipid phosphatase activity 2/1193 19/18639 0.105263157894737 1.64459346186086 0.345722543766614 0.81465857273307 GO:0042834 peptidoglycan binding 2/1193 19/18639 0.105263157894737 1.64459346186086 0.345722543766614 0.81465857273307 GO:0046624 sphingolipid transporter activity 2/1193 19/18639 0.105263157894737 1.64459346186086 0.345722543766614 0.81465857273307 GO:0050145 nucleoside monophosphate kinase activity 2/1193 19/18639 0.105263157894737 1.64459346186086 0.345722543766614 0.81465857273307 GO:0097001 ceramide binding 2/1193 19/18639 0.105263157894737 1.64459346186086 0.345722543766614 0.81465857273307 GO:0071889 14-3-3 protein binding 3/1193 33/18639 0.0909090909090909 1.42033071706165 0.354594002866744 0.833815186657364 GO:0001614 purinergic nucleotide receptor activity 2/1193 20/18639 0.1 1.56236378876781 0.36940148949249 0.849097565984968 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1193 20/18639 0.1 1.56236378876781 0.36940148949249 0.849097565984968 GO:0016502 nucleotide receptor activity 2/1193 20/18639 0.1 1.56236378876781 0.36940148949249 0.849097565984968 GO:0030742 GTP-dependent protein binding 2/1193 20/18639 0.1 1.56236378876781 0.36940148949249 0.849097565984968 GO:0042288 MHC class I protein binding 2/1193 20/18639 0.1 1.56236378876781 0.36940148949249 0.849097565984968 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/1193 48/18639 0.0833333333333333 1.30196982397318 0.369421090965972 0.849097565984968 GO:0032266 phosphatidylinositol-3-phosphate binding 4/1193 48/18639 0.0833333333333333 1.30196982397318 0.369421090965972 0.849097565984968 GO:0140693 molecular condensate scaffold activity 4/1193 48/18639 0.0833333333333333 1.30196982397318 0.369421090965972 0.849097565984968 GO:0140789 histone phosphatase activity 10/1193 136/18639 0.0735294117647059 1.14879690350574 0.372225889216898 0.849097565984968 GO:0008175 tRNA methyltransferase activity 3/1193 34/18639 0.0882352941176471 1.37855628420689 0.372424466219386 0.849097565984968 GO:0008376 acetylgalactosaminyltransferase activity 3/1193 34/18639 0.0882352941176471 1.37855628420689 0.372424466219386 0.849097565984968 GO:0016831 carboxy-lyase activity 3/1193 34/18639 0.0882352941176471 1.37855628420689 0.372424466219386 0.849097565984968 GO:0051427 hormone receptor binding 3/1193 34/18639 0.0882352941176471 1.37855628420689 0.372424466219386 0.849097565984968 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/1193 34/18639 0.0882352941176471 1.37855628420689 0.372424466219386 0.849097565984968 GO:0090482 vitamin transmembrane transporter activity 3/1193 34/18639 0.0882352941176471 1.37855628420689 0.372424466219386 0.849097565984968 GO:0046906 tetrapyrrole binding 11/1193 152/18639 0.0723684210526316 1.13065800502934 0.381717716080445 0.85306162750251 GO:0016763 pentosyltransferase activity 4/1193 49/18639 0.0816326530612245 1.27539901123903 0.384235578483342 0.85306162750251 GO:0035254 glutamate receptor binding 4/1193 49/18639 0.0816326530612245 1.27539901123903 0.384235578483342 0.85306162750251 GO:0005343 organic acid:sodium symporter activity 3/1193 35/18639 0.0857142857142857 1.33916896180098 0.390157595176206 0.85306162750251 GO:0001846 opsonin binding 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0005248 voltage-gated sodium channel activity 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0009975 cyclase activity 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0015125 bile acid transmembrane transporter activity 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0015174 basic amino acid transmembrane transporter activity 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0036122 BMP binding 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0051010 microtubule plus-end binding 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0061891 calcium ion sensor activity 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0072542 protein phosphatase activator activity 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0140312 cargo adaptor activity 2/1193 21/18639 0.0952380952380952 1.4879655131122 0.392732306971555 0.85306162750251 GO:0016835 carbon-oxygen lyase activity 6/1193 79/18639 0.0759493670886076 1.18660540919074 0.39420832784222 0.85306162750251 GO:0032813 tumor necrosis factor receptor superfamily binding 4/1193 50/18639 0.08 1.24989103101425 0.399006911793909 0.85306162750251 GO:0160215 deacylase activity 5/1193 65/18639 0.0769230769230769 1.20181829905216 0.403475173583443 0.85306162750251 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/1193 36/18639 0.0833333333333333 1.30196982397318 0.407762419110929 0.85306162750251 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/1193 36/18639 0.0833333333333333 1.30196982397318 0.407762419110929 0.85306162750251 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/1193 36/18639 0.0833333333333333 1.30196982397318 0.407762419110929 0.85306162750251 GO:0003743 translation initiation factor activity 4/1193 51/18639 0.0784313725490196 1.22538336373946 0.413715976729582 0.85306162750251 GO:0016830 carbon-carbon lyase activity 4/1193 51/18639 0.0784313725490196 1.22538336373946 0.413715976729582 0.85306162750251 GO:0019001 guanyl nucleotide binding 27/1193 400/18639 0.0675 1.05459555741827 0.41563047745439 0.85306162750251 GO:0032561 guanyl ribonucleotide binding 27/1193 400/18639 0.0675 1.05459555741827 0.41563047745439 0.85306162750251 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/1193 22/18639 0.0909090909090909 1.42033071706165 0.415662560705471 0.85306162750251 GO:0016881 acid-amino acid ligase activity 2/1193 22/18639 0.0909090909090909 1.42033071706165 0.415662560705471 0.85306162750251 GO:0034062 5'-3' RNA polymerase activity 2/1193 22/18639 0.0909090909090909 1.42033071706165 0.415662560705471 0.85306162750251 GO:0061133 endopeptidase activator activity 2/1193 22/18639 0.0909090909090909 1.42033071706165 0.415662560705471 0.85306162750251 GO:0097747 RNA polymerase activity 2/1193 22/18639 0.0909090909090909 1.42033071706165 0.415662560705471 0.85306162750251 GO:0140517 protein-RNA adaptor activity 2/1193 22/18639 0.0909090909090909 1.42033071706165 0.415662560705471 0.85306162750251 GO:0140784 metal ion sensor activity 2/1193 22/18639 0.0909090909090909 1.42033071706165 0.415662560705471 0.85306162750251 GO:0030971 receptor tyrosine kinase binding 6/1193 81/18639 0.0740740740740741 1.15730651019838 0.417438849915649 0.85306162750251 GO:0020037 heme binding 10/1193 142/18639 0.0704225352112676 1.10025618927311 0.424646951876925 0.85306162750251 GO:0019213 deacetylase activity 3/1193 37/18639 0.0810810810810811 1.26678145035228 0.42521042839835 0.85306162750251 GO:0022829 wide pore channel activity 3/1193 37/18639 0.0810810810810811 1.26678145035228 0.42521042839835 0.85306162750251 GO:0043394 proteoglycan binding 3/1193 37/18639 0.0810810810810811 1.26678145035228 0.42521042839835 0.85306162750251 GO:0005261 monoatomic cation channel activity 23/1193 341/18639 0.0674486803519062 1.05379375781993 0.42815411981789 0.85306162750251 GO:0003712 transcription coregulator activity 33/1193 495/18639 0.0666666666666667 1.04157585917854 0.429714865638836 0.85306162750251 GO:0008168 methyltransferase activity 14/1193 204/18639 0.0686274509803922 1.07221044327203 0.433402940067333 0.85306162750251 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0005212 structural constituent of eye lens 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0005283 amino acid:sodium symporter activity 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0016493 C-C chemokine receptor activity 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0016849 phosphorus-oxygen lyase activity 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0017134 fibroblast growth factor binding 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0031681 G-protein beta-subunit binding 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0043274 phospholipase binding 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0070577 lysine-acetylated histone binding 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/1193 23/18639 0.0869565217391304 1.35857720762418 0.438147942050424 0.85306162750251 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 6/1193 83/18639 0.072289156626506 1.12941960633818 0.440559180643472 0.85306162750251 GO:0030165 PDZ domain binding 6/1193 83/18639 0.072289156626506 1.12941960633818 0.440559180643472 0.85306162750251 GO:1990841 promoter-specific chromatin binding 5/1193 68/18639 0.0735294117647059 1.14879690350574 0.441986261093039 0.85306162750251 GO:0005109 frizzled binding 3/1193 38/18639 0.0789473684210526 1.23344509639564 0.442475507875772 0.85306162750251 GO:0004864 protein phosphatase inhibitor activity 4/1193 53/18639 0.0754716981132075 1.17914248208891 0.442875921335178 0.85306162750251 GO:0008146 sulfotransferase activity 4/1193 53/18639 0.0754716981132075 1.17914248208891 0.442875921335178 0.85306162750251 GO:0038064 collagen receptor activity 4/1193 53/18639 0.0754716981132075 1.17914248208891 0.442875921335178 0.85306162750251 GO:0051018 protein kinase A binding 4/1193 53/18639 0.0754716981132075 1.17914248208891 0.442875921335178 0.85306162750251 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/1193 130/18639 0.0692307692307692 1.08163646914695 0.453703165510489 0.85306162750251 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/1193 39/18639 0.0769230769230769 1.20181829905216 0.459533861001489 0.85306162750251 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/1193 39/18639 0.0769230769230769 1.20181829905216 0.459533861001489 0.85306162750251 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/1193 39/18639 0.0769230769230769 1.20181829905216 0.459533861001489 0.85306162750251 GO:0043130 ubiquitin binding 7/1193 100/18639 0.07 1.09365465213747 0.459988249970235 0.85306162750251 GO:0005315 phosphate transmembrane transporter activity 2/1193 24/18639 0.0833333333333333 1.30196982397318 0.460151445167301 0.85306162750251 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/1193 24/18639 0.0833333333333333 1.30196982397318 0.460151445167301 0.85306162750251 GO:0019957 C-C chemokine binding 2/1193 24/18639 0.0833333333333333 1.30196982397318 0.460151445167301 0.85306162750251 GO:0050431 transforming growth factor beta binding 2/1193 24/18639 0.0833333333333333 1.30196982397318 0.460151445167301 0.85306162750251 GO:0140033 acetylation-dependent protein binding 2/1193 24/18639 0.0833333333333333 1.30196982397318 0.460151445167301 0.85306162750251 GO:0016782 transferase activity, transferring sulphur-containing groups 5/1193 70/18639 0.0714285714285714 1.11597413483415 0.467331107446701 0.85306162750251 GO:0008236 serine-type peptidase activity 13/1193 194/18639 0.0670103092783505 1.04694480690627 0.473391173251266 0.85306162750251 GO:0004177 aminopeptidase activity 3/1193 40/18639 0.075 1.17177284157586 0.476363926663841 0.85306162750251 GO:0015036 disulfide oxidoreductase activity 3/1193 40/18639 0.075 1.17177284157586 0.476363926663841 0.85306162750251 GO:0030331 nuclear estrogen receptor binding 3/1193 40/18639 0.075 1.17177284157586 0.476363926663841 0.85306162750251 GO:0003707 nuclear steroid receptor activity 2/1193 25/18639 0.08 1.24989103101425 0.481642615026586 0.85306162750251 GO:0008139 nuclear localization sequence binding 2/1193 25/18639 0.08 1.24989103101425 0.481642615026586 0.85306162750251 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/1193 25/18639 0.08 1.24989103101425 0.481642615026586 0.85306162750251 GO:0019211 phosphatase activator activity 2/1193 25/18639 0.08 1.24989103101425 0.481642615026586 0.85306162750251 GO:0120020 cholesterol transfer activity 2/1193 25/18639 0.08 1.24989103101425 0.481642615026586 0.85306162750251 GO:0001094 TFIID-class transcription factor complex binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0004090 carbonyl reductase (NADPH) activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0004382 GDP phosphatase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0004935 adrenergic receptor activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0004955 prostaglandin receptor activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0005031 tumor necrosis factor receptor activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0005522 profilin binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0008519 ammonium channel activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0015203 polyamine transmembrane transporter activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0016783 sulfurtransferase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0031419 cobalamin binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0031996 thioesterase binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0032052 bile acid binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0035374 chondroitin sulfate binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0043295 glutathione binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0045322 unmethylated CpG binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0050815 phosphoserine residue binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0051864 histone H3K36 demethylase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0070097 delta-catenin binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0071723 lipopeptide binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0099122 RNA polymerase II C-terminal domain binding 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0140940 histone H2A methyltransferase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:1990259 histone H2AQ104 methyltransferase activity 1/1193 10/18639 0.1 1.56236378876781 0.483986726832174 0.85306162750251 GO:0008509 monoatomic anion transmembrane transporter activity 10/1193 149/18639 0.0671140939597315 1.04856630118645 0.485507524569925 0.85306162750251 GO:0019212 phosphatase inhibitor activity 4/1193 56/18639 0.0714285714285714 1.11597413483415 0.485729457497401 0.85306162750251 GO:0051087 protein-folding chaperone binding 9/1193 134/18639 0.0671641791044776 1.04934881335152 0.490290028364957 0.85306162750251 GO:0001530 lipopolysaccharide binding 3/1193 41/18639 0.0731707317073171 1.14319301617157 0.492946290351527 0.85306162750251 GO:0001727 lipid kinase activity 3/1193 41/18639 0.0731707317073171 1.14319301617157 0.492946290351527 0.85306162750251 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/1193 41/18639 0.0731707317073171 1.14319301617157 0.492946290351527 0.85306162750251 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/1193 41/18639 0.0731707317073171 1.14319301617157 0.492946290351527 0.85306162750251 GO:0017080 sodium channel regulator activity 3/1193 41/18639 0.0731707317073171 1.14319301617157 0.492946290351527 0.85306162750251 GO:0042287 MHC protein binding 3/1193 41/18639 0.0731707317073171 1.14319301617157 0.492946290351527 0.85306162750251 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/1193 41/18639 0.0731707317073171 1.14319301617157 0.492946290351527 0.85306162750251 GO:0016504 peptidase activator activity 4/1193 57/18639 0.0701754385964912 1.09639564124057 0.499720433479319 0.85306162750251 GO:0015631 tubulin binding 25/1193 385/18639 0.0649350649350649 1.01452194075832 0.500173431372962 0.85306162750251 GO:0001637 G protein-coupled chemoattractant receptor activity 2/1193 26/18639 0.0769230769230769 1.20181829905216 0.502596861631869 0.85306162750251 GO:0004950 chemokine receptor activity 2/1193 26/18639 0.0769230769230769 1.20181829905216 0.502596861631869 0.85306162750251 GO:0008066 glutamate receptor activity 2/1193 26/18639 0.0769230769230769 1.20181829905216 0.502596861631869 0.85306162750251 GO:0008143 poly(A) binding 2/1193 26/18639 0.0769230769230769 1.20181829905216 0.502596861631869 0.85306162750251 GO:0005216 monoatomic ion channel activity 29/1193 448/18639 0.0647321428571429 1.01135155969345 0.502769551589614 0.85306162750251 GO:0017171 serine hydrolase activity 13/1193 198/18639 0.0656565656565657 1.02579440676675 0.503426356512931 0.85306162750251 GO:0032182 ubiquitin-like protein binding 8/1193 120/18639 0.0666666666666667 1.04157585917854 0.505201138709305 0.85306162750251 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 11/1193 167/18639 0.0658682634730539 1.02910189679317 0.505642036505219 0.85306162750251 GO:0019838 growth factor binding 9/1193 136/18639 0.0661764705882353 1.03391721315517 0.508352244421448 0.85306162750251 GO:0004520 DNA endonuclease activity 3/1193 42/18639 0.0714285714285714 1.11597413483415 0.509263591178034 0.85306162750251 GO:0016859 cis-trans isomerase activity 3/1193 42/18639 0.0714285714285714 1.11597413483415 0.509263591178034 0.85306162750251 GO:0042056 chemoattractant activity 3/1193 42/18639 0.0714285714285714 1.11597413483415 0.509263591178034 0.85306162750251 GO:0016741 transferase activity, transferring one-carbon groups 14/1193 215/18639 0.0651162790697674 1.01735316477904 0.513206118803036 0.85306162750251 GO:0016247 channel regulator activity 11/1193 168/18639 0.0654761904761905 1.02297629026464 0.513740191860405 0.85306162750251 GO:0004540 RNA nuclease activity 8/1193 121/18639 0.0661157024793388 1.03296779422665 0.514739903570111 0.85306162750251 GO:0015108 chloride transmembrane transporter activity 8/1193 121/18639 0.0661157024793388 1.03296779422665 0.514739903570111 0.85306162750251 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0001851 complement component C3b binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0002162 dystroglycan binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0004016 adenylate cyclase activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0004954 prostanoid receptor activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0005225 volume-sensitive anion channel activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0008432 JUN kinase binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0008503 benzodiazepine receptor activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0015217 ADP transmembrane transporter activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0019206 nucleoside kinase activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0019215 intermediate filament binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0032050 clathrin heavy chain binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0034511 U3 snoRNA binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0042608 T cell receptor binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0048185 activin binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0050998 nitric-oxide synthase binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0070697 activin receptor binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0180030 inositol phosphate kinase activity 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:1900750 oligopeptide binding 1/1193 11/18639 0.0909090909090909 1.42033071706165 0.517032184714466 0.85306162750251 GO:0000149 SNARE binding 7/1193 106/18639 0.0660377358490566 1.0317496718278 0.522035046643817 0.85306162750251 GO:0001671 ATPase activator activity 2/1193 27/18639 0.0740740740740741 1.15730651019838 0.522994835076856 0.85306162750251 GO:0004364 glutathione transferase activity 2/1193 27/18639 0.0740740740740741 1.15730651019838 0.522994835076856 0.85306162750251 GO:0005385 zinc ion transmembrane transporter activity 2/1193 27/18639 0.0740740740740741 1.15730651019838 0.522994835076856 0.85306162750251 GO:0008266 poly(U) RNA binding 2/1193 27/18639 0.0740740740740741 1.15730651019838 0.522994835076856 0.85306162750251 GO:0008320 protein transmembrane transporter activity 2/1193 27/18639 0.0740740740740741 1.15730651019838 0.522994835076856 0.85306162750251 GO:0008395 steroid hydroxylase activity 2/1193 27/18639 0.0740740740740741 1.15730651019838 0.522994835076856 0.85306162750251 GO:0023026 MHC class II protein complex binding 2/1193 27/18639 0.0740740740740741 1.15730651019838 0.522994835076856 0.85306162750251 GO:0008200 ion channel inhibitor activity 3/1193 43/18639 0.0697674418604651 1.09002124797754 0.525300426057927 0.85306162750251 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1193 43/18639 0.0697674418604651 1.09002124797754 0.525300426057927 0.85306162750251 GO:0030246 carbohydrate binding 18/1193 280/18639 0.0642857142857143 1.00437672135074 0.527503460672137 0.85306162750251 GO:0141108 transporter regulator activity 11/1193 170/18639 0.0647058823529412 1.01094127508506 0.529818224812574 0.85306162750251 GO:0019888 protein phosphatase regulator activity 7/1193 107/18639 0.0654205607476635 1.02210715153034 0.532129363294439 0.85306162750251 GO:0140101 catalytic activity, acting on a tRNA 9/1193 139/18639 0.0647482014388489 1.01160245315902 0.53506548426838 0.85306162750251 GO:0001664 G protein-coupled receptor binding 19/1193 297/18639 0.063973063973064 0.999491986080419 0.535168467699458 0.85306162750251 GO:0001046 core promoter sequence-specific DNA binding 3/1193 44/18639 0.0681818181818182 1.06524803779624 0.54104325215813 0.85306162750251 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/1193 44/18639 0.0681818181818182 1.06524803779624 0.54104325215813 0.85306162750251 GO:0043014 alpha-tubulin binding 3/1193 44/18639 0.0681818181818182 1.06524803779624 0.54104325215813 0.85306162750251 GO:0052689 carboxylic ester hydrolase activity 6/1193 92/18639 0.0652173913043478 1.01893290571814 0.541415092579427 0.85306162750251 GO:0046625 sphingolipid binding 2/1193 28/18639 0.0714285714285714 1.11597413483415 0.542821856467931 0.85306162750251 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/1193 28/18639 0.0714285714285714 1.11597413483415 0.542821856467931 0.85306162750251 GO:0097718 disordered domain specific binding 2/1193 28/18639 0.0714285714285714 1.11597413483415 0.542821856467931 0.85306162750251 GO:0005525 GTP binding 24/1193 378/18639 0.0634920634920635 0.991977008741468 0.546997340435824 0.85306162750251 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0003995 acyl-CoA dehydrogenase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0004126 cytidine deaminase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0004526 ribonuclease P activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0005025 transforming growth factor beta receptor activity, type I 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0005026 transforming growth factor beta receptor activity, type II 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0005078 MAP-kinase scaffold activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0005095 GTPase inhibitor activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0005165 neurotrophin receptor binding 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0008504 monoamine transmembrane transporter activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0010853 cyclase activator activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0015166 polyol transmembrane transporter activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0015269 calcium-activated potassium channel activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0016273 arginine N-methyltransferase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0016274 protein-arginine N-methyltransferase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0016361 activin receptor activity, type I 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0016362 activin receptor activity, type II 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0017002 activin receptor activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0035197 siRNA binding 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0036009 protein-glutamine N-methyltransferase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0042301 phosphate ion binding 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0043047 single-stranded telomeric DNA binding 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0097677 STAT family protein binding 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0140900 chloride:bicarbonate antiporter activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/1193 12/18639 0.0833333333333333 1.30196982397318 0.547963073893961 0.85306162750251 GO:0005244 voltage-gated monoatomic ion channel activity 11/1193 173/18639 0.0635838150289017 0.993410501528667 0.55359807143348 0.857554617102681 GO:0140030 modification-dependent protein binding 11/1193 173/18639 0.0635838150289017 0.993410501528667 0.55359807143348 0.857554617102681 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/1193 61/18639 0.0655737704918033 1.02450084509365 0.553900935957782 0.857554617102681 GO:0019905 syntaxin binding 4/1193 61/18639 0.0655737704918033 1.02450084509365 0.553900935957782 0.857554617102681 GO:0003785 actin monomer binding 2/1193 29/18639 0.0689655172413793 1.07749226811573 0.562067400130303 0.863162247353703 GO:0004181 metallocarboxypeptidase activity 2/1193 29/18639 0.0689655172413793 1.07749226811573 0.562067400130303 0.863162247353703 GO:0005416 amino acid:monoatomic cation symporter activity 2/1193 29/18639 0.0689655172413793 1.07749226811573 0.562067400130303 0.863162247353703 GO:0051861 glycolipid binding 2/1193 29/18639 0.0689655172413793 1.07749226811573 0.562067400130303 0.863162247353703 GO:0042562 hormone binding 6/1193 94/18639 0.0638297872340425 0.997253482192221 0.562775583767701 0.863162247353703 GO:0022832 voltage-gated channel activity 11/1193 175/18639 0.0628571428571429 0.982057238654054 0.569196178621102 0.863162247353703 GO:0004535 poly(A)-specific ribonuclease activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0005035 death receptor activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0005172 vascular endothelial growth factor receptor binding 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0005542 folic acid binding 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0008417 fucosyltransferase activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0009982 pseudouridine synthase activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0017154 semaphorin receptor activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0019104 DNA N-glycosylase activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0031432 titin binding 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0035325 Toll-like receptor binding 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0070123 transforming growth factor beta receptor activity, type III 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0097157 pre-mRNA intronic binding 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:1901338 catecholamine binding 1/1193 13/18639 0.0769230769230769 1.20181829905216 0.576914598715162 0.863162247353703 GO:0015079 potassium ion transmembrane transporter activity 10/1193 160/18639 0.0625 0.976477367979883 0.577489332749097 0.863162247353703 GO:0099106 ion channel regulator activity 10/1193 160/18639 0.0625 0.976477367979883 0.577489332749097 0.863162247353703 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 8/1193 128/18639 0.0625 0.976477367979883 0.579538439822546 0.86340539167841 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1193 30/18639 0.0666666666666667 1.04157585917854 0.580724622872667 0.86340539167841 GO:0008187 poly-pyrimidine tract binding 2/1193 30/18639 0.0666666666666667 1.04157585917854 0.580724622872667 0.86340539167841 GO:0031624 ubiquitin conjugating enzyme binding 2/1193 30/18639 0.0666666666666667 1.04157585917854 0.580724622872667 0.86340539167841 GO:0140938 histone H3 methyltransferase activity 3/1193 47/18639 0.0638297872340425 0.997253482192221 0.586398089995986 0.863546362329837 GO:0033192 calmodulin-dependent protein phosphatase activity 5/1193 81/18639 0.0617283950617284 0.964422091831983 0.598310556106026 0.863546362329837 GO:0140791 histone H2AXS140 phosphatase activity 5/1193 81/18639 0.0617283950617284 0.964422091831983 0.598310556106026 0.863546362329837 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/1193 81/18639 0.0617283950617284 0.964422091831983 0.598310556106026 0.863546362329837 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/1193 81/18639 0.0617283950617284 0.964422091831983 0.598310556106026 0.863546362329837 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/1193 81/18639 0.0617283950617284 0.964422091831983 0.598310556106026 0.863546362329837 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/1193 81/18639 0.0617283950617284 0.964422091831983 0.598310556106026 0.863546362329837 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/1193 81/18639 0.0617283950617284 0.964422091831983 0.598310556106026 0.863546362329837 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/1193 81/18639 0.0617283950617284 0.964422091831983 0.598310556106026 0.863546362329837 GO:0005452 solute:inorganic anion antiporter activity 2/1193 31/18639 0.0645161290322581 1.00797663791472 0.598789936415419 0.863546362329837 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 30/1193 484/18639 0.0619834710743802 0.968407307087487 0.600252105613895 0.863546362329837 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/1193 48/18639 0.0625 0.976477367979883 0.600863223264654 0.863546362329837 GO:0038187 pattern recognition receptor activity 3/1193 48/18639 0.0625 0.976477367979883 0.600863223264654 0.863546362329837 GO:0008017 microtubule binding 17/1193 276/18639 0.0615942028985507 0.962325522067131 0.601062945453214 0.863546362329837 GO:0008174 mRNA methyltransferase activity 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0032454 histone H3K9 demethylase activity 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0042813 Wnt receptor activity 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0061665 SUMO ligase activity 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0070742 C2H2 zinc finger domain binding 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0098821 BMP receptor activity 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0098847 sequence-specific single stranded DNA binding 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:1901474 azole transmembrane transporter activity 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:1901612 cardiolipin binding 1/1193 14/18639 0.0714285714285714 1.11597413483415 0.604013325426899 0.863546362329837 GO:0038024 cargo receptor activity 4/1193 65/18639 0.0615384615384615 0.961454639241731 0.604792286818908 0.863546362329837 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/1193 82/18639 0.0609756097560976 0.952660846809642 0.609303615200948 0.863546362329837 GO:0033549 MAP kinase phosphatase activity 5/1193 82/18639 0.0609756097560976 0.952660846809642 0.609303615200948 0.863546362329837 GO:0005004 GPI-linked ephrin receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0005008 hepatocyte growth factor receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0005009 insulin receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0005011 macrophage colony-stimulating factor receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0005020 stem cell factor receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0008288 boss receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0036332 placental growth factor receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0038062 protein tyrosine kinase collagen receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0060175 brain-derived neurotrophic factor receptor activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0060590 ATPase regulator activity 3/1193 49/18639 0.0612244897959184 0.956549258429273 0.614991113141696 0.863546362329837 GO:0015106 bicarbonate transmembrane transporter activity 2/1193 32/18639 0.0625 0.976477367979883 0.616262619392627 0.863546362329837 GO:0022884 macromolecule transmembrane transporter activity 2/1193 32/18639 0.0625 0.976477367979883 0.616262619392627 0.863546362329837 GO:0120015 sterol transfer activity 2/1193 32/18639 0.0625 0.976477367979883 0.616262619392627 0.863546362329837 GO:0019208 phosphatase regulator activity 7/1193 117/18639 0.0598290598290598 0.93474756592946 0.627703451048165 0.863546362329837 GO:1990782 protein tyrosine kinase binding 7/1193 117/18639 0.0598290598290598 0.93474756592946 0.627703451048165 0.863546362329837 GO:0005006 epidermal growth factor receptor activity 3/1193 50/18639 0.06 0.937418273260687 0.628777338759639 0.863546362329837 GO:0005007 fibroblast growth factor receptor activity 3/1193 50/18639 0.06 0.937418273260687 0.628777338759639 0.863546362329837 GO:0005017 platelet-derived growth factor receptor activity 3/1193 50/18639 0.06 0.937418273260687 0.628777338759639 0.863546362329837 GO:0005019 platelet-derived growth factor beta-receptor activity 3/1193 50/18639 0.06 0.937418273260687 0.628777338759639 0.863546362329837 GO:0008173 RNA methyltransferase activity 4/1193 67/18639 0.0597014925373134 0.932754500756903 0.628869415990239 0.863546362329837 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0004953 icosanoid receptor activity 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0005041 low-density lipoprotein particle receptor activity 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0010181 FMN binding 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0015116 sulfate transmembrane transporter activity 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0030553 cGMP binding 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0033130 acetylcholine receptor binding 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0034483 heparan sulfate sulfotransferase activity 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0042809 nuclear vitamin D receptor binding 1/1193 15/18639 0.0666666666666667 1.04157585917854 0.629377733629085 0.863546362329837 GO:0017018 myosin phosphatase activity 5/1193 84/18639 0.0595238095238095 0.929978445695126 0.630757618748039 0.863546362329837 GO:0051117 ATPase binding 5/1193 84/18639 0.0595238095238095 0.929978445695126 0.630757618748039 0.863546362329837 GO:0001216 DNA-binding transcription activator activity 30/1193 491/18639 0.0610997963340122 0.95460109293349 0.632049776554932 0.864262711493605 GO:0030296 protein tyrosine kinase activator activity 2/1193 33/18639 0.0606060606060606 0.946887144707765 0.633144465620104 0.864707629838392 GO:0005201 extracellular matrix structural constituent 10/1193 168/18639 0.0595238095238095 0.929978445695126 0.639581559190932 0.872438922974039 GO:0005010 insulin-like growth factor receptor activity 3/1193 51/18639 0.0588235294117647 0.919037522804595 0.642218673886518 0.872858270191592 GO:0005021 vascular endothelial growth factor receptor activity 3/1193 51/18639 0.0588235294117647 0.919037522804595 0.642218673886518 0.872858270191592 GO:0005030 neurotrophin receptor activity 3/1193 51/18639 0.0588235294117647 0.919037522804595 0.642218673886518 0.872858270191592 GO:0016779 nucleotidyltransferase activity 8/1193 136/18639 0.0588235294117647 0.919037522804595 0.648239844052834 0.872895904136503 GO:0015035 protein-disulfide reductase activity 2/1193 34/18639 0.0588235294117647 0.919037522804595 0.649439465582649 0.872895904136503 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1193 34/18639 0.0588235294117647 0.919037522804595 0.649439465582649 0.872895904136503 GO:0004722 protein serine/threonine phosphatase activity 6/1193 103/18639 0.058252427184466 0.910114828408434 0.652409567853714 0.872895904136503 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0005024 transforming growth factor beta receptor activity 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0005149 interleukin-1 receptor binding 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0015378 sodium:chloride symporter activity 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0043023 ribosomal large subunit binding 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0070411 I-SMAD binding 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1193 16/18639 0.0625 0.976477367979883 0.653118732543416 0.872895904136503 GO:0005080 protein kinase C binding 3/1193 52/18639 0.0576923076923077 0.901363724289122 0.655313000460399 0.87409587684706 GO:0008234 cysteine-type peptidase activity 11/1193 187/18639 0.0588235294117647 0.919037522804595 0.65745891159791 0.87409587684706 GO:0043015 gamma-tubulin binding 2/1193 35/18639 0.0571428571428571 0.892779307867321 0.665153518334554 0.87409587684706 GO:0061631 ubiquitin conjugating enzyme activity 2/1193 35/18639 0.0571428571428571 0.892779307867321 0.665153518334554 0.87409587684706 GO:0140566 histone reader activity 2/1193 35/18639 0.0571428571428571 0.892779307867321 0.665153518334554 0.87409587684706 GO:0005003 ephrin receptor activity 3/1193 53/18639 0.0566037735849057 0.884356861566686 0.668059225207912 0.87409587684706 GO:0005005 transmembrane-ephrin receptor activity 3/1193 53/18639 0.0566037735849057 0.884356861566686 0.668059225207912 0.87409587684706 GO:0005544 calcium-dependent phospholipid binding 3/1193 53/18639 0.0566037735849057 0.884356861566686 0.668059225207912 0.87409587684706 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1193 53/18639 0.0566037735849057 0.884356861566686 0.668059225207912 0.87409587684706 GO:0017046 peptide hormone binding 3/1193 53/18639 0.0566037735849057 0.884356861566686 0.668059225207912 0.87409587684706 GO:0140299 molecular sensor activity 4/1193 71/18639 0.0563380281690141 0.880204951418486 0.674121464378596 0.87409587684706 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0004549 tRNA-specific ribonuclease activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0004659 prenyltransferase activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0005092 GDP-dissociation inhibitor activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0008569 minus-end-directed microtubule motor activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0009881 photoreceptor activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0016018 cyclosporin A binding 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0030548 acetylcholine receptor regulator activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0032183 SUMO binding 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0032977 membrane insertase activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0036041 long-chain fatty acid binding 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0045125 bioactive lipid receptor activity 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0046965 nuclear retinoid X receptor binding 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:1990226 histone methyltransferase binding 1/1193 17/18639 0.0588235294117647 0.919037522804595 0.675340144350091 0.87409587684706 GO:0008013 beta-catenin binding 6/1193 106/18639 0.0566037735849057 0.884356861566686 0.679640750507331 0.87409587684706 GO:0005484 SNAP receptor activity 2/1193 36/18639 0.0555555555555556 0.867979882648785 0.680294171230062 0.87409587684706 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/1193 36/18639 0.0555555555555556 0.867979882648785 0.680294171230062 0.87409587684706 GO:0045505 dynein intermediate chain binding 2/1193 36/18639 0.0555555555555556 0.867979882648785 0.680294171230062 0.87409587684706 GO:0003925 G protein activity 3/1193 54/18639 0.0555555555555556 0.867979882648785 0.680457199502827 0.87409587684706 GO:0051287 NAD binding 3/1193 54/18639 0.0555555555555556 0.867979882648785 0.680457199502827 0.87409587684706 GO:0140463 chromatin-protein adaptor activity 3/1193 54/18639 0.0555555555555556 0.867979882648785 0.680457199502827 0.87409587684706 GO:0003823 antigen binding 10/1193 174/18639 0.0574712643678161 0.897910223429777 0.682732844518733 0.876017942053717 GO:0070001 aspartic-type peptidase activity 2/1193 37/18639 0.0540540540540541 0.84452096690152 0.69487038510616 0.881149112747017 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/1193 73/18639 0.0547945205479452 0.856089747270034 0.695261357996413 0.881149112747017 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0015172 acidic amino acid transmembrane transporter activity 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0015373 monoatomic anion:sodium symporter activity 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0017075 syntaxin-1 binding 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0022851 GABA-gated chloride ion channel activity 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0030228 lipoprotein particle receptor activity 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0050811 GABA receptor binding 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0099602 neurotransmitter receptor regulator activity 1/1193 18/18639 0.0555555555555556 0.867979882648785 0.696139156689815 0.881149112747017 GO:0022843 voltage-gated monoatomic cation channel activity 8/1193 143/18639 0.0559440559440559 0.874049672037937 0.702699118587572 0.888451978956615 GO:0019955 cytokine binding 8/1193 144/18639 0.0555555555555556 0.867979882648785 0.710014677177136 0.892721401595388 GO:0004519 endonuclease activity 7/1193 127/18639 0.0551181102362205 0.861145395383834 0.711281942308385 0.892721401595388 GO:0019003 GDP binding 4/1193 75/18639 0.0533333333333333 0.833260687342833 0.715401940282241 0.892721401595388 GO:0004890 GABA-A receptor activity 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0008301 DNA binding, bending 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0015245 fatty acid transmembrane transporter activity 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0030506 ankyrin binding 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0031420 alkali metal ion binding 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0034987 immunoglobulin receptor binding 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0043395 heparan sulfate proteoglycan binding 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0140036 ubiquitin-modified protein reader activity 1/1193 19/18639 0.0526315789473684 0.822296730930428 0.715606746296659 0.892721401595388 GO:0008194 UDP-glycosyltransferase activity 8/1193 145/18639 0.0551724137931034 0.861993814492586 0.717211356477989 0.893731224702061 GO:0031490 chromatin DNA binding 7/1193 128/18639 0.0546875 0.854417696982397 0.718903467245582 0.894847726671134 GO:0005326 neurotransmitter transmembrane transporter activity 1/1193 20/18639 0.05 0.781181894383906 0.733828075602142 0.899779513666175 GO:0010851 cyclase regulator activity 1/1193 20/18639 0.05 0.781181894383906 0.733828075602142 0.899779513666175 GO:0015095 magnesium ion transmembrane transporter activity 1/1193 20/18639 0.05 0.781181894383906 0.733828075602142 0.899779513666175 GO:0016004 phospholipase activator activity 1/1193 20/18639 0.05 0.781181894383906 0.733828075602142 0.899779513666175 GO:0016505 peptidase activator activity involved in apoptotic process 1/1193 20/18639 0.05 0.781181894383906 0.733828075602142 0.899779513666175 GO:0043024 ribosomal small subunit binding 1/1193 20/18639 0.05 0.781181894383906 0.733828075602142 0.899779513666175 GO:0061608 nuclear import signal receptor activity 1/1193 20/18639 0.05 0.781181894383906 0.733828075602142 0.899779513666175 GO:0140939 histone H4 methyltransferase activity 1/1193 20/18639 0.05 0.781181894383906 0.733828075602142 0.899779513666175 GO:0008276 protein methyltransferase activity 5/1193 95/18639 0.0526315789473684 0.822296730930428 0.735219397886423 0.899779513666175 GO:0016887 ATP hydrolysis activity 24/1193 417/18639 0.0575539568345324 0.899202180585791 0.735309142116344 0.899779513666175 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/1193 40/18639 0.05 0.781181894383906 0.735318907543148 0.899779513666175 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/1193 40/18639 0.05 0.781181894383906 0.735318907543148 0.899779513666175 GO:0061791 GTPase motor activity 2/1193 40/18639 0.05 0.781181894383906 0.735318907543148 0.899779513666175 GO:0071855 neuropeptide receptor binding 2/1193 40/18639 0.05 0.781181894383906 0.735318907543148 0.899779513666175 GO:1990606 membrane scission GTPase motor activity 2/1193 40/18639 0.05 0.781181894383906 0.735318907543148 0.899779513666175 GO:0015103 inorganic anion transmembrane transporter activity 9/1193 165/18639 0.0545454545454545 0.852198430236988 0.736250828507587 0.899779513666175 GO:0015459 potassium channel regulator activity 3/1193 59/18639 0.0508474576271186 0.794422265475159 0.737274850610807 0.899779513666175 GO:0036002 pre-mRNA binding 3/1193 59/18639 0.0508474576271186 0.794422265475159 0.737274850610807 0.899779513666175 GO:0019199 transmembrane receptor protein kinase activity 4/1193 78/18639 0.0512820512820513 0.801212199368109 0.743747818370099 0.906694737362246 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/1193 60/18639 0.05 0.781181894383906 0.747623859150692 0.907162635785355 GO:0004812 aminoacyl-tRNA ligase activity 2/1193 41/18639 0.0487804878048781 0.762128677447713 0.747748272527334 0.907162635785355 GO:0016875 ligase activity, forming carbon-oxygen bonds 2/1193 41/18639 0.0487804878048781 0.762128677447713 0.747748272527334 0.907162635785355 GO:0042169 SH2 domain binding 2/1193 41/18639 0.0487804878048781 0.762128677447713 0.747748272527334 0.907162635785355 GO:0005123 death receptor binding 1/1193 21/18639 0.0476190476190476 0.743982756556101 0.750882864033671 0.907162635785355 GO:0008373 sialyltransferase activity 1/1193 21/18639 0.0476190476190476 0.743982756556101 0.750882864033671 0.907162635785355 GO:0035613 RNA stem-loop binding 1/1193 21/18639 0.0476190476190476 0.743982756556101 0.750882864033671 0.907162635785355 GO:0070182 DNA polymerase binding 1/1193 21/18639 0.0476190476190476 0.743982756556101 0.750882864033671 0.907162635785355 GO:0019842 vitamin binding 8/1193 150/18639 0.0533333333333333 0.833260687342833 0.751395386046411 0.907162635785355 GO:0033293 monocarboxylic acid binding 4/1193 79/18639 0.0506329113924051 0.791070272793829 0.752704311454305 0.907767860595106 GO:0015276 ligand-gated monoatomic ion channel activity 10/1193 186/18639 0.0537634408602151 0.839980531595598 0.759106199828608 0.912100113055766 GO:0019894 kinesin binding 2/1193 42/18639 0.0476190476190476 0.743982756556101 0.759672506594799 0.912100113055766 GO:0031492 nucleosomal DNA binding 2/1193 42/18639 0.0476190476190476 0.743982756556101 0.759672506594799 0.912100113055766 GO:0051879 Hsp90 protein binding 2/1193 42/18639 0.0476190476190476 0.743982756556101 0.759672506594799 0.912100113055766 GO:0000049 tRNA binding 4/1193 80/18639 0.05 0.781181894383906 0.761417925953436 0.912100113055766 GO:0003713 transcription coactivator activity 14/1193 256/18639 0.0546875 0.854417696982397 0.765931753239955 0.912100113055766 GO:0005243 gap junction channel activity 1/1193 22/18639 0.0454545454545455 0.710165358530824 0.766845735620728 0.912100113055766 GO:0008649 rRNA methyltransferase activity 1/1193 22/18639 0.0454545454545455 0.710165358530824 0.766845735620728 0.912100113055766 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1193 22/18639 0.0454545454545455 0.710165358530824 0.766845735620728 0.912100113055766 GO:0033691 sialic acid binding 1/1193 22/18639 0.0454545454545455 0.710165358530824 0.766845735620728 0.912100113055766 GO:0050321 tau-protein kinase activity 1/1193 22/18639 0.0454545454545455 0.710165358530824 0.766845735620728 0.912100113055766 GO:0070034 telomerase RNA binding 1/1193 22/18639 0.0454545454545455 0.710165358530824 0.766845735620728 0.912100113055766 GO:0140035 ubiquitin-like protein reader activity 1/1193 22/18639 0.0454545454545455 0.710165358530824 0.766845735620728 0.912100113055766 GO:0022834 ligand-gated channel activity 10/1193 188/18639 0.0531914893617021 0.831044568493517 0.77049533555509 0.915472259158478 GO:0099094 ligand-gated monoatomic cation channel activity 7/1193 136/18639 0.0514705882352941 0.804157832454021 0.774915318929826 0.919751656258843 GO:0022824 transmitter-gated monoatomic ion channel activity 3/1193 63/18639 0.0476190476190476 0.743982756556101 0.776717849791809 0.919948222514219 GO:0022835 transmitter-gated channel activity 3/1193 63/18639 0.0476190476190476 0.743982756556101 0.776717849791809 0.919948222514219 GO:0005539 glycosaminoglycan binding 13/1193 242/18639 0.0537190082644628 0.839286332809155 0.781244487816974 0.92045669512341 GO:0005158 insulin receptor binding 1/1193 23/18639 0.0434782608695652 0.679288603812092 0.781786544419379 0.92045669512341 GO:0016917 GABA receptor activity 1/1193 23/18639 0.0434782608695652 0.679288603812092 0.781786544419379 0.92045669512341 GO:0140102 catalytic activity, acting on a rRNA 1/1193 23/18639 0.0434782608695652 0.679288603812092 0.781786544419379 0.92045669512341 GO:0016790 thiolester hydrolase activity 2/1193 44/18639 0.0454545454545455 0.710165358530824 0.782060626194712 0.92045669512341 GO:0030547 signaling receptor inhibitor activity 2/1193 44/18639 0.0454545454545455 0.710165358530824 0.782060626194712 0.92045669512341 GO:0008135 translation factor activity, RNA binding 4/1193 83/18639 0.0481927710843374 0.752946404225452 0.786126578164309 0.923861816593404 GO:0051539 4 iron, 4 sulfur cluster binding 2/1193 45/18639 0.0444444444444444 0.694383906119028 0.792552734920446 0.923861816593404 GO:0180051 translation factor activity 4/1193 84/18639 0.0476190476190476 0.743982756556101 0.793895026135123 0.923861816593404 GO:0003697 single-stranded DNA binding 6/1193 121/18639 0.0495867768595041 0.77472584566999 0.794216158550096 0.923861816593404 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0004622 lysophospholipase activity 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0004806 triacylglycerol lipase activity 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0005540 hyaluronic acid binding 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0015295 solute:proton symporter activity 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0050699 WW domain binding 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0060229 lipase activator activity 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0070840 dynein complex binding 1/1193 24/18639 0.0416666666666667 0.650984911986588 0.795770679169469 0.923861816593404 GO:0005253 monoatomic anion channel activity 5/1193 103/18639 0.0485436893203883 0.758429023673695 0.796460943308726 0.923861816593404 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/1193 46/18639 0.0434782608695652 0.679288603812092 0.802595976590445 0.929450819613628 GO:0001848 complement binding 1/1193 25/18639 0.04 0.624945515507125 0.808859348508756 0.929450819613628 GO:0005251 delayed rectifier potassium channel activity 1/1193 25/18639 0.04 0.624945515507125 0.808859348508756 0.929450819613628 GO:0017025 TBP-class protein binding 1/1193 25/18639 0.04 0.624945515507125 0.808859348508756 0.929450819613628 GO:0042974 nuclear retinoic acid receptor binding 1/1193 25/18639 0.04 0.624945515507125 0.808859348508756 0.929450819613628 GO:0047617 fatty acyl-CoA hydrolase activity 1/1193 25/18639 0.04 0.624945515507125 0.808859348508756 0.929450819613628 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1193 25/18639 0.04 0.624945515507125 0.808859348508756 0.929450819613628 GO:0046982 protein heterodimerization activity 20/1193 369/18639 0.0542005420054201 0.84680964160857 0.8102312184147 0.929450819613628 GO:0016500 protein-hormone receptor activity 3/1193 67/18639 0.0447761194029851 0.699565875567677 0.811159014349001 0.929450819613628 GO:0042054 histone methyltransferase activity 3/1193 67/18639 0.0447761194029851 0.699565875567677 0.811159014349001 0.929450819613628 GO:0022836 gated channel activity 17/1193 318/18639 0.0534591194968553 0.835225924812981 0.811811084868176 0.929450819613628 GO:0005504 fatty acid binding 2/1193 47/18639 0.0425531914893617 0.664835654794814 0.812204771550199 0.929450819613628 GO:0043495 protein-membrane adaptor activity 2/1193 47/18639 0.0425531914893617 0.664835654794814 0.812204771550199 0.929450819613628 GO:0005267 potassium channel activity 6/1193 124/18639 0.0483870967741935 0.755982478436038 0.812856010391634 0.929450819613628 GO:0004497 monooxygenase activity 5/1193 106/18639 0.0471698113207547 0.736964051305572 0.816345847977904 0.929754615105245 GO:0003777 microtubule motor activity 3/1193 68/18639 0.0441176470588235 0.689278142103447 0.819033294403356 0.929754615105245 GO:0140223 general transcription initiation factor activity 3/1193 68/18639 0.0441176470588235 0.689278142103447 0.819033294403356 0.929754615105245 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/1193 26/18639 0.0384615384615385 0.600909149526082 0.821109847983831 0.929754615105245 GO:0016289 acyl-CoA hydrolase activity 1/1193 26/18639 0.0384615384615385 0.600909149526082 0.821109847983831 0.929754615105245 GO:0030247 polysaccharide binding 1/1193 26/18639 0.0384615384615385 0.600909149526082 0.821109847983831 0.929754615105245 GO:0030507 spectrin binding 1/1193 26/18639 0.0384615384615385 0.600909149526082 0.821109847983831 0.929754615105245 GO:0034237 protein kinase A regulatory subunit binding 1/1193 26/18639 0.0384615384615385 0.600909149526082 0.821109847983831 0.929754615105245 GO:0070006 metalloaminopeptidase activity 1/1193 26/18639 0.0384615384615385 0.600909149526082 0.821109847983831 0.929754615105245 GO:0008188 neuropeptide receptor activity 2/1193 48/18639 0.0416666666666667 0.650984911986588 0.821393534519136 0.929754615105245 GO:0016279 protein-lysine N-methyltransferase activity 3/1193 69/18639 0.0434782608695652 0.679288603812092 0.826626327684704 0.934736410782301 GO:0005044 scavenger receptor activity 1/1193 27/18639 0.037037037037037 0.57865325509919 0.832575810018715 0.939573504478951 GO:0005104 fibroblast growth factor receptor binding 1/1193 27/18639 0.037037037037037 0.57865325509919 0.832575810018715 0.939573504478951 GO:0016278 lysine N-methyltransferase activity 3/1193 70/18639 0.0428571428571429 0.669584480900491 0.833944918391636 0.940174612108525 GO:0016755 aminoacyltransferase activity 27/1193 496/18639 0.0544354838709677 0.850480288240543 0.835268453323862 0.940723187911845 GO:0048020 CCR chemokine receptor binding 2/1193 50/18639 0.04 0.624945515507125 0.838568252843221 0.943494210406187 GO:0005242 inward rectifier potassium channel activity 1/1193 28/18639 0.0357142857142857 0.557987067417076 0.843307437928003 0.943760879279429 GO:0008527 taste receptor activity 1/1193 28/18639 0.0357142857142857 0.557987067417076 0.843307437928003 0.943760879279429 GO:0016866 intramolecular transferase activity 1/1193 28/18639 0.0357142857142857 0.557987067417076 0.843307437928003 0.943760879279429 GO:0046966 nuclear thyroid hormone receptor binding 1/1193 28/18639 0.0357142857142857 0.557987067417076 0.843307437928003 0.943760879279429 GO:0141052 histone H3 demethylase activity 1/1193 28/18639 0.0357142857142857 0.557987067417076 0.843307437928003 0.943760879279429 GO:0005272 sodium channel activity 2/1193 51/18639 0.0392156862745098 0.61269168186973 0.846582521372066 0.943760879279429 GO:0016597 amino acid binding 2/1193 51/18639 0.0392156862745098 0.61269168186973 0.846582521372066 0.943760879279429 GO:0030544 Hsp70 protein binding 2/1193 51/18639 0.0392156862745098 0.61269168186973 0.846582521372066 0.943760879279429 GO:0042379 chemokine receptor binding 3/1193 72/18639 0.0416666666666667 0.650984911986588 0.8477863753253 0.943760879279429 GO:0043178 alcohol binding 4/1193 92/18639 0.0434782608695652 0.679288603812092 0.848128915173968 0.943760879279429 GO:0031072 heat shock protein binding 6/1193 131/18639 0.0458015267175573 0.715586468137929 0.851180031603498 0.943760879279429 GO:0031406 carboxylic acid binding 9/1193 187/18639 0.0481283422459893 0.751939791385578 0.852844313985128 0.943760879279429 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/1193 29/18639 0.0344827586206897 0.538746134057866 0.853351724992207 0.943760879279429 GO:0035250 UDP-galactosyltransferase activity 1/1193 29/18639 0.0344827586206897 0.538746134057866 0.853351724992207 0.943760879279429 GO:0097472 cyclin-dependent protein kinase activity 1/1193 29/18639 0.0344827586206897 0.538746134057866 0.853351724992207 0.943760879279429 GO:0051213 dioxygenase activity 4/1193 93/18639 0.043010752688172 0.671984425276478 0.853978443652332 0.943760879279429 GO:0004521 RNA endonuclease activity 3/1193 73/18639 0.0410958904109589 0.642067310452526 0.854323161782252 0.943760879279429 GO:0031491 nucleosome binding 3/1193 74/18639 0.0405405405405405 0.63339072517614 0.860613301191825 0.943760879279429 GO:0043177 organic acid binding 9/1193 189/18639 0.0476190476190476 0.743982756556101 0.861031735728873 0.943760879279429 GO:0140296 general transcription initiation factor binding 2/1193 53/18639 0.0377358490566038 0.589571241044457 0.861534246404636 0.943760879279429 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/1193 53/18639 0.0377358490566038 0.589571241044457 0.861534246404636 0.943760879279429 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/1193 30/18639 0.0333333333333333 0.520787929589271 0.862752659548053 0.943760879279429 GO:0032452 histone demethylase activity 1/1193 30/18639 0.0333333333333333 0.520787929589271 0.862752659548053 0.943760879279429 GO:0033612 receptor serine/threonine kinase binding 1/1193 30/18639 0.0333333333333333 0.520787929589271 0.862752659548053 0.943760879279429 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/1193 30/18639 0.0333333333333333 0.520787929589271 0.862752659548053 0.943760879279429 GO:0048019 receptor antagonist activity 1/1193 30/18639 0.0333333333333333 0.520787929589271 0.862752659548053 0.943760879279429 GO:0070566 adenylyltransferase activity 1/1193 30/18639 0.0333333333333333 0.520787929589271 0.862752659548053 0.943760879279429 GO:0101005 deubiquitinase activity 5/1193 115/18639 0.0434782608695652 0.679288603812092 0.866758022820444 0.943760879279429 GO:0008201 heparin binding 8/1193 172/18639 0.0465116279069767 0.726680831985029 0.866991052066167 0.943760879279429 GO:0015485 cholesterol binding 2/1193 54/18639 0.037037037037037 0.57865325509919 0.868498748208552 0.943760879279429 GO:0005506 iron ion binding 7/1193 154/18639 0.0454545454545455 0.710165358530824 0.870018977771236 0.943760879279429 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1193 31/18639 0.032258064516129 0.503988318957359 0.871551416985807 0.943760879279429 GO:0008327 methyl-CpG binding 1/1193 31/18639 0.032258064516129 0.503988318957359 0.871551416985807 0.943760879279429 GO:0016411 acylglycerol O-acyltransferase activity 1/1193 31/18639 0.032258064516129 0.503988318957359 0.871551416985807 0.943760879279429 GO:0017147 Wnt-protein binding 1/1193 31/18639 0.032258064516129 0.503988318957359 0.871551416985807 0.943760879279429 GO:0047499 calcium-independent phospholipase A2 activity 1/1193 31/18639 0.032258064516129 0.503988318957359 0.871551416985807 0.943760879279429 GO:0070273 phosphatidylinositol-4-phosphate binding 1/1193 31/18639 0.032258064516129 0.503988318957359 0.871551416985807 0.943760879279429 GO:0072349 modified amino acid transmembrane transporter activity 1/1193 31/18639 0.032258064516129 0.503988318957359 0.871551416985807 0.943760879279429 GO:0140457 protein demethylase activity 1/1193 31/18639 0.032258064516129 0.503988318957359 0.871551416985807 0.943760879279429 GO:0016757 glycosyltransferase activity 13/1193 267/18639 0.048689138576779 0.760701470186575 0.879336431615437 0.946079140119136 GO:0008378 galactosyltransferase activity 1/1193 32/18639 0.03125 0.488238683989941 0.879786539488813 0.946079140119136 GO:0031369 translation initiation factor binding 1/1193 32/18639 0.03125 0.488238683989941 0.879786539488813 0.946079140119136 GO:0047498 calcium-dependent phospholipase A2 activity 1/1193 32/18639 0.03125 0.488238683989941 0.879786539488813 0.946079140119136 GO:0140142 nucleocytoplasmic carrier activity 1/1193 32/18639 0.03125 0.488238683989941 0.879786539488813 0.946079140119136 GO:0019787 ubiquitin-like protein transferase activity 25/1193 479/18639 0.0521920668058455 0.815429952384036 0.8802348584088 0.946079140119136 GO:0005249 voltage-gated potassium channel activity 4/1193 98/18639 0.0408163265306122 0.637699505619515 0.88042596135642 0.946079140119136 GO:0008170 N-methyltransferase activity 4/1193 98/18639 0.0408163265306122 0.637699505619515 0.88042596135642 0.946079140119136 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/1193 56/18639 0.0357142857142857 0.557987067417076 0.88147058326009 0.946296977635473 GO:0043021 ribonucleoprotein complex binding 8/1193 177/18639 0.0451977401129944 0.706153124866808 0.886017024855438 0.950270167879306 GO:0005125 cytokine activity 11/1193 234/18639 0.047008547008547 0.734444516087433 0.889872308797267 0.953495209807558 GO:0051082 unfolded protein binding 5/1193 121/18639 0.0413223140495868 0.645604871391658 0.893450116597344 0.955627626098247 GO:0048306 calcium-dependent protein binding 3/1193 80/18639 0.0375 0.58588642078793 0.89356284255272 0.955627626098247 GO:0030332 cyclin binding 1/1193 34/18639 0.0294117647058824 0.459518761402298 0.894707881227954 0.955942641159906 GO:0016853 isomerase activity 8/1193 180/18639 0.0444444444444444 0.694383906119028 0.896307969802221 0.956742790178249 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 8/1193 181/18639 0.0441988950276243 0.690547530947099 0.899560260193421 0.958969005257362 GO:0004623 phospholipase A2 activity 1/1193 35/18639 0.0285714285714286 0.446389653933661 0.901459480136584 0.958969005257362 GO:1901681 sulfur compound binding 13/1193 275/18639 0.0472727272727273 0.738571972872057 0.901993106734697 0.958969005257362 GO:0001098 basal transcription machinery binding 2/1193 60/18639 0.0333333333333333 0.520787929589271 0.903933169929857 0.958969005257362 GO:0001099 basal RNA polymerase II transcription machinery binding 2/1193 60/18639 0.0333333333333333 0.520787929589271 0.903933169929857 0.958969005257362 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/1193 60/18639 0.0333333333333333 0.520787929589271 0.903933169929857 0.958969005257362 GO:0005254 chloride channel activity 3/1193 83/18639 0.036144578313253 0.564709803169089 0.907262141648692 0.958969005257362 GO:0000993 RNA polymerase II complex binding 1/1193 36/18639 0.0277777777777778 0.433989941324392 0.907778488962484 0.958969005257362 GO:0004033 aldo-keto reductase (NADPH) activity 1/1193 36/18639 0.0277777777777778 0.433989941324392 0.907778488962484 0.958969005257362 GO:0004190 aspartic-type endopeptidase activity 1/1193 36/18639 0.0277777777777778 0.433989941324392 0.907778488962484 0.958969005257362 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1193 36/18639 0.0277777777777778 0.433989941324392 0.907778488962484 0.958969005257362 GO:0019783 ubiquitin-like protein peptidase activity 5/1193 127/18639 0.0393700787401575 0.615103853845595 0.91539401565098 0.966105984593146 GO:0042162 telomeric DNA binding 1/1193 38/18639 0.0263157894736842 0.411148365465214 0.91922774566737 0.968333632736761 GO:0042887 amide transmembrane transporter activity 1/1193 38/18639 0.0263157894736842 0.411148365465214 0.91922774566737 0.968333632736761 GO:0004843 cysteine-type deubiquitinase activity 4/1193 108/18639 0.037037037037037 0.57865325509919 0.921076256047902 0.969372389323821 GO:0004620 phospholipase activity 4/1193 109/18639 0.036697247706422 0.573344509639564 0.924369018872784 0.970560275319332 GO:0000217 DNA secondary structure binding 1/1193 39/18639 0.0256410256410256 0.400606099684054 0.924408182171796 0.970560275319332 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/1193 130/18639 0.0384615384615385 0.600909149526082 0.924795422479542 0.970560275319332 GO:0004842 ubiquitin-protein transferase activity 22/1193 449/18639 0.0489977728285078 0.76552345997532 0.925733600248054 0.970638588319788 GO:0032451 demethylase activity 1/1193 40/18639 0.025 0.390590947191953 0.929256625110992 0.973424460973677 GO:0008227 G protein-coupled amine receptor activity 1/1193 41/18639 0.024390243902439 0.381064338723857 0.933794333925583 0.976518167770894 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/1193 67/18639 0.0298507462686567 0.466377250378451 0.933947535901878 0.976518167770894 GO:0032934 sterol binding 2/1193 68/18639 0.0294117647058824 0.459518761402298 0.937429785644258 0.978977082196399 GO:0043175 RNA polymerase core enzyme binding 1/1193 42/18639 0.0238095238095238 0.371991378278051 0.93804120776292 0.978977082196399 GO:0098960 postsynaptic neurotransmitter receptor activity 2/1193 69/18639 0.0289855072463768 0.452859069208062 0.940737351553498 0.980177361933011 GO:0016758 hexosyltransferase activity 8/1193 197/18639 0.0406091370558376 0.634462452291497 0.940935385699038 0.980177361933011 GO:0008375 acetylglucosaminyltransferase activity 1/1193 43/18639 0.0232558139534884 0.363340415992514 0.942015872447484 0.980394296880529 GO:0061630 ubiquitin protein ligase activity 16/1193 353/18639 0.0453257790368272 0.7081535586483 0.946393652549611 0.983777866621138 GO:0061659 ubiquitin-like protein ligase activity 17/1193 372/18639 0.0456989247311828 0.713983451856258 0.94701748370469 0.983777866621138 GO:0008009 chemokine activity 1/1193 45/18639 0.0222222222222222 0.347191953059514 0.949217194326467 0.984659613422744 GO:0030594 neurotransmitter receptor activity 3/1193 97/18639 0.0309278350515464 0.4832052954952 0.952325197557943 0.984659613422744 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1193 46/18639 0.0217391304347826 0.339644301906046 0.95247544360949 0.984659613422744 GO:0003678 DNA helicase activity 2/1193 74/18639 0.027027027027027 0.42226048345076 0.954926515412593 0.984659613422744 GO:0061749 forked DNA-dependent helicase activity 1/1193 47/18639 0.0212765957446809 0.332417827397407 0.955524806045562 0.984659613422744 GO:0099095 ligand-gated monoatomic anion channel activity 1/1193 47/18639 0.0212765957446809 0.332417827397407 0.955524806045562 0.984659613422744 GO:0140359 ABC-type transporter activity 1/1193 47/18639 0.0212765957446809 0.332417827397407 0.955524806045562 0.984659613422744 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/1193 47/18639 0.0212765957446809 0.332417827397407 0.955524806045562 0.984659613422744 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/1193 122/18639 0.0327868852459016 0.512250422546824 0.957221194679212 0.984659613422744 GO:0009378 four-way junction helicase activity 1/1193 48/18639 0.0208333333333333 0.325492455993294 0.958378662886549 0.984659613422744 GO:0036121 double-stranded DNA helicase activity 1/1193 48/18639 0.0208333333333333 0.325492455993294 0.958378662886549 0.984659613422744 GO:0043138 3'-5' DNA helicase activity 1/1193 48/18639 0.0208333333333333 0.325492455993294 0.958378662886549 0.984659613422744 GO:0051536 iron-sulfur cluster binding 2/1193 76/18639 0.0263157894736842 0.411148365465214 0.959638270946849 0.985053348442245 GO:0051540 metal cluster binding 2/1193 77/18639 0.025974025974026 0.405808776303328 0.961813331407375 0.986385204837491 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/1193 52/18639 0.0192307692307692 0.300454574763041 0.968077807051623 0.991904699294461 GO:0016298 lipase activity 4/1193 130/18639 0.0307692307692308 0.480727319620865 0.970270053345972 0.993217724301496 GO:0017069 snRNA binding 1/1193 54/18639 0.0185185185185185 0.289326627549595 0.972044230612862 0.993217724301496 GO:0005496 steroid binding 3/1193 108/18639 0.0277777777777778 0.433989941324392 0.9723520442058 0.993217724301496 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4/1193 132/18639 0.0303030303030303 0.473443572353883 0.972893874071127 0.993217724301496 GO:0008374 O-acyltransferase activity 1/1193 55/18639 0.0181818181818182 0.284066143412329 0.973838754846322 0.993280181894071 GO:0043022 ribosome binding 3/1193 112/18639 0.0267857142857143 0.418490300562807 0.977414233970024 0.995394786716857 GO:0017116 single-stranded DNA helicase activity 1/1193 58/18639 0.0172413793103448 0.269373067028933 0.978560745698438 0.995394786716857 GO:0042393 histone binding 9/1193 247/18639 0.0364372469635627 0.569282352182604 0.979470778565513 0.995394786716857 GO:0070063 RNA polymerase binding 1/1193 59/18639 0.0169491525423729 0.264807421825053 0.979937260976505 0.995394786716857 GO:0140767 enzyme-substrate adaptor activity 4/1193 139/18639 0.0287769784172662 0.449601090292896 0.980465154759271 0.995394786716857 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/1193 60/18639 0.0166666666666667 0.260393964794635 0.981225465909499 0.995394786716857 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/1193 91/18639 0.021978021978022 0.343376656872047 0.982623526287407 0.995914196165054 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1193 122/18639 0.0245901639344262 0.384187816910118 0.986491881821968 0.998492929658185 GO:0016407 acetyltransferase activity 2/1193 96/18639 0.0208333333333333 0.325492455993294 0.986944523888117 0.998492929658185 GO:0008080 N-acetyltransferase activity 1/1193 69/18639 0.0144927536231884 0.226429534604031 0.989669829934266 0.999999999979862 GO:0035064 methylated histone binding 1/1193 74/18639 0.0135135135135135 0.21113024172538 0.992588503641692 0.999999999979862 GO:0044183 protein folding chaperone 1/1193 75/18639 0.0133333333333333 0.208315171835708 0.993064771627443 0.999999999979862 GO:0098631 cell adhesion mediator activity 1/1193 76/18639 0.0131578947368421 0.205574182732607 0.993510458303184 0.999999999979862 GO:0140034 methylation-dependent protein binding 1/1193 76/18639 0.0131578947368421 0.205574182732607 0.993510458303184 0.999999999979862 GO:0016410 N-acyltransferase activity 1/1193 94/18639 0.0106382978723404 0.166208913698703 0.998038005496477 0.999999999979862 GO:0005179 hormone activity 2/1193 132/18639 0.0151515151515152 0.236721786176941 0.998421213009582 0.999999999979862 GO:0042626 ATPase-coupled transmembrane transporter activity 1/1193 98/18639 0.0102040816326531 0.159424876404879 0.998496238609535 0.999999999979862 GO:0005549 odorant binding 1/1193 111/18639 0.00900900900900901 0.140753494483587 0.999366765448599 0.999999999979862 GO:0003730 mRNA 3'-UTR binding 6/1193 262/18639 0.0229007633587786 0.357793234068965 0.999438300813082 0.999999999979862 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4/1193 229/18639 0.0174672489082969 0.272901971837172 0.999808881927462 0.999999999979862 GO:0045182 translation regulator activity 3/1193 356/18639 0.00842696629213483 0.131659869839984 0.999999984357673 0.999999999979862 GO:0004984 olfactory receptor activity 2/1193 419/18639 0.00477326968973747 0.0745758371726879 0.999999999979862 0.999999999979862