category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	85/1162	233/9376	2.94357072680668	COL1A2/COL4A1/SYNPO2/ELN/COL4A2/ACTB/LMNA/COL1A1/THBS1/PDLIM3/BGN/COL27A1/COL6A3/FBN2/ACTG2/ITGA1/TPM4/SSPN/COL5A2/MYL9/DAAM1/VIM/SDC2/TPM2/COL5A3/COL3A1/DSP/TPM1/CSRP1/COMP/COL6A2/ATP1B1/PDLIM7/TLN1/NID2/FHL2/ACTG1/VCAN/SGCD/PDLIM2/VCL/MYH11/THBS2/COL5A1/ITGA11/ITGB1/COL6A1/MYH9/LMOD1/PDLIM1/SDC3/DAAM2/FHL3/NEBL/ITGAV/LDB3/COL4A5/MYH10/SYNE1/ITGA5/FMNL3/HSPG2/FLNC/ITGB3/FBLN2/MYH13/TMOD3/LMNB2/TLN2/TNNI3/ZYX/SGCB/ATP1A2/SNTB2/TNNC2/DIAPH3/THBS3/AGRN/DAG1/FBN1/SNTB1/ANK2/MYOZ1/ITGB5/ENO3	11.2991377407413
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	70/1162	205/9376	2.7552159858948	MT-ND3/COL1A2/ATP5F1E/NDUFA4L2/COL1A1/TGFB3/UQCR11/NDUFA3/MT-ND5/NDUFB2/NDUFB3/COL3A1/COX7A1/RYR2/UQCRQ/NDUFB7/NDUFB4/COX7A2/MT-ATP8/COX6C/COX8A/NDUFA2/NDUFS6/NDUFA4/PRKCD/NDUFA13/COX6B1/NDUFA6/CAMK2G/NDUFS8/NDUFA7/NDUFA11/PRKCG/TGFB2/GFPT1/AKT1/MT-ND6/GAPDH/NDUFC1/ATP2A2/ATP5MC1/COX6A1/UQCR10/MT-CO3/NDUFB11/COX7B/MT-CYB/NDUFB6/COX4I2/ATP2A3/COX7C/TBC1D4/PTPA/PPARA/MTOR/ATP5PB/MT-CO2/PARP1/TNNI3/TGFBR2/SLC25A5/GSK3B/NDUFB1/ATP5F1A/ATP5MC3/NDUFS1/AGER/PIK3R2/NDUFV3/TGFBR1	9.5567560999099
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	73/1162	235/9376	2.50649284066357	MT-ND3/ATP5F1E/ACTB/NDUFA4L2/UQCR11/NDUFA3/MT-ND5/CREB3L2/NDUFB2/ATP5MF/NDUFB3/COX7A1/UQCRQ/NDUFB7/SMARCA4/NDUFB4/COX7A2/MT-ATP8/ACTG1/COX6C/MGLL/COX8A/NDUFA2/NDUFS6/NDUFA4/ADCY5/NDUFA13/COX6B1/NDUFA6/PRKACA/NDUFS8/NDUFA7/NDUFA11/ADCY6/MAP3K5/ATP5ME/MT-ND6/NDUFC1/SMARCD3/ATP5MC1/COX6A1/UQCR10/MT-CO3/COX17/NDUFB11/COX7B/FRS2/SMARCD1/MT-CYB/NDUFB6/COX4I2/SMARCD2/FGFR1/COX7C/PRKAG2/MTOR/ATP5PB/MT-CO2/DPF1/SMARCB1/ACSL4/NDUFAF5/NDUFB1/COA7/ATP5F1A/ATP5MC3/NDUFAF8/NDUFS1/NDUFV3/RPS6KB2/CREB3/SIRT6/ATP5MGL	8.79661331983303
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	52/1162	138/9376	3.04043503205368	MT-ND3/ATP5F1E/NDUFA4L2/UQCR11/NDUFA3/MT-ND5/NDUFB2/ATP5MF/NDUFB3/COX7A1/UQCRQ/NDUFB7/NDUFB4/COX7A2/MT-ATP8/COX6C/COX8A/NDUFA2/NDUFS6/NDUFA4/NDUFA13/COX6B1/NDUFA6/NDUFS8/NDUFA7/NDUFA11/ATP5ME/MT-ND6/NDUFC1/ATP5MC1/COX6A1/UQCR10/MT-CO3/COX17/NDUFB11/COX7B/MT-CYB/NDUFB6/COX4I2/COX7C/PPA1/ATP5PB/MT-CO2/ATP6V0D1/NDUFB1/ATP5F1A/ATP5MC3/NDUFS1/NDUFV3/ATP6V1E2/CYCS/ATP5MGL	9.08206672935571
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	66/1162	203/9376	2.62336891549308	COL1A2/COL4A1/COL4A2/ACTN1/ACTB/COL1A1/THBS1/COL6A3/ITGA1/LAMB3/VASP/MYL9/MYLK/COMP/COL6A2/ACTN4/TLN1/CCND1/TNC/ACTG1/PDGFA/FLNB/CAPN2/FLNA/PTK2/VCL/THBS2/LAMA4/ITGA11/ITGB1/COL6A1/PARVA/CRK/EMP1/PRKCG/AKT1/ITGAV/IGF1/DOCK1/COL4A5/JUN/ITGA5/CCND2/MYL10/PGF/VAV2/BCAR1/ILK/SHC1/ITGB3/ROCK2/TLN2/ZYX/SRC/PIP5K1C/GSK3B/THBS3/EGFR/SPP1/PIP5K1A/CTNNB1/RAPGEF1/PPP1R12A/ITGB5/PIK3R2/PPP1R12B	8.79469739409836
NA	NA	hsa04518	Integrin signaling	52/1162	154/9376	2.72454567807408	COL1A2/COL4A1/COL4A2/ACTN1/ACTB/COL1A1/THBS1/COL6A3/ITGA1/LAMB3/FERMT2/COMP/COL6A2/ACTN4/TLN1/CCND1/TNC/ACTG1/PDGFA/FLNB/FLNA/PTK2/VCL/THBS2/LAMA4/ITGA11/ITGB1/COL6A1/FRAS1/PARVA/AKT1/ITGAV/IGF1/COL4A5/ITGA5/CCND2/PGF/ILK/LIMS1/ITGB3/MTOR/TLN2/SRC/GSK3B/THBS3/NCK2/EGFR/SPP1/CTNNB1/FBN1/ITGB5/PIK3R2	8.11584709998858
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	95/1162	388/9376	1.97561971006264	MT-ND3/ATP5F1E/NDUFA4L2/UQCR11/NDUFA3/CACNA1C/MT-ND5/NDUFB2/CALM1/NDUFB3/COX7A1/TUBB6/UQCRQ/NDUFB7/NDUFB4/WIPI1/WNT2B/COX7A2/MT-ATP8/CAPN2/COX6C/PSENEN/TUBA1A/COX8A/NDUFA2/NDUFS6/NDUFA4/NDUFA13/COX6B1/NDUFA6/SLC39A4/CAPN1/WNT11/NDUFS8/NDUFA7/NDUFA11/XBP1/LRP5/PTGS2/MAP3K5/AKT1/MT-ND6/TUBA1B/GAPDH/NDUFC1/ATP2A2/ADAM17/ATP5MC1/SLC39A7/COX6A1/SLC39A3/UQCR10/MT-CO3/LRP6/TUBB2A/NDUFB11/SLC39A13/PSMD1/COX7B/FZD1/MT-CYB/NDUFB6/COX4I2/ATP2A3/COX7C/PSMC4/MTOR/ATP5PB/MT-CO2/KLC2/SLC39A11/APP/ATG101/SLC25A5/BACE1/GSK3B/WNT3A/PSMD14/IL6/NDUFB1/MME/CTNNB1/MAPT/ATP5F1A/ATP5MC3/NDUFS1/MCU/AGER/PSEN2/DVL3/PIK3R2/NDUFV3/CYCS/TUBA1C/TUBB4B	7.38203754192073
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	73/1162	268/9376	2.1978575281938	MT-ND3/ATP5F1E/NDUFA4L2/UQCR11/NDUFA3/MT-ND5/DUSP1/NDUFB2/CALM1/NDUFB3/COX7A1/TUBB6/UQCRQ/NDUFB7/NDUFB4/COX7A2/MT-ATP8/COX6C/TUBA1A/COX8A/NDUFA2/NDUFS6/NDUFA4/ADCY5/NDUFA13/COX6B1/NDUFA6/CAMK2G/SLC39A4/PRKACA/NDUFS8/NDUFA7/NDUFA11/XBP1/GNAI2/MAP3K5/MT-ND6/TUBA1B/NDUFC1/PINK1/ATP5MC1/SLC39A7/COX6A1/SLC39A3/UQCR10/MT-CO3/TUBB2A/NDUFB11/SLC39A13/PSMD1/UBE2J1/COX7B/MT-CYB/NDUFB6/COX4I2/COX7C/PSMC4/ATP5PB/MT-CO2/KLC2/SLC39A11/SLC25A5/PSMD14/NDUFB1/MAPT/ATP5F1A/ATP5MC3/NDUFS1/MCU/NDUFV3/CYCS/TUBA1C/TUBB4B	7.48294245849923
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	76/1162	308/9376	1.99101414936183	MT-ND3/ATP5F1E/NDUFA4L2/UQCR11/HIP1/NDUFA3/GPX7/POLR2L/MT-ND5/CREB3L2/NDUFB2/NDUFB3/COX7A1/TUBB6/UQCRQ/ACTR1A/NDUFB7/NDUFB4/WIPI1/COX7A2/MT-ATP8/GPX8/COX6C/TUBA1A/COX8A/NDUFA2/NDUFS6/NDUFA4/NDUFA13/COX6B1/NDUFA6/NDUFS8/NDUFA7/NDUFA11/MAP3K5/MT-ND6/TUBA1B/NDUFC1/ATP5MC1/COX6A1/UQCR10/MT-CO3/DCTN2/TUBB2A/NDUFB11/PSMD1/COX7B/MT-CYB/NDUFB6/COX4I2/SIN3A/COX7C/PSMC4/MTOR/IFT57/ATP5PB/AP2S1/MT-CO2/CLTCL1/SLC1A2/KLC2/ATG101/POLR2J/SLC25A5/PSMD14/NDUFB1/ATP5F1A/ATP5MC3/NDUFS1/NDUFV3/CYCS/CREB3/TUBA1C/TFAM/TUBB4B/AP2A2	6.65136545818936
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	70/1162	275/9376	2.0538882803943	MT-ND3/NCAM2/ATP5F1E/NDUFA4L2/UQCR11/NDUFA3/CACNA1C/EGR1/MT-ND5/CREB3L2/NDUFB2/NDUFB3/COX7A1/TUBB6/RYR2/UQCRQ/NDUFB7/NDUFB4/COX7A2/MT-ATP8/COX6C/TUBA1A/COX8A/NDUFA2/NDUFS6/NDUFA4/PRKCD/NDUFA13/COX6B1/NDUFA6/PRKACA/NDUFS8/NDUFA7/NDUFA11/HSPA8/MT-ND6/TUBA1B/NDUFC1/ATP5MC1/COX6A1/UQCR10/MT-CO3/TUBB2A/NDUFB11/PSMD1/COX7B/MT-CYB/NDUFB6/COX4I2/COX7C/PSMC4/ATP5PB/MT-CO2/KLC2/SLC25A5/GSK3B/PSMD14/IL6/NDUFB1/ATP5F1A/ATP5MC3/NDUFS1/MCU/PIK3R2/NDUFV3/C9/CYCS/CREB3/TUBA1C/TUBB4B	6.6715649399074
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	47/1162	157/9376	2.4155146518741	NDUFA4L2/UQCR11/NDUFA3/FOS/NDUFB2/NDUFB3/COX7A1/UQCRQ/NDUFB7/NDUFB4/COX7A2/COX6C/COX8A/NDUFA2/NDUFS6/NDUFA4/NDUFA13/COX6B1/NDUFA6/MLXIP/NDUFS8/NDUFA7/NDUFA11/XBP1/MAP3K5/AKT1/NDUFC1/COX6A1/JUN/UQCR10/MT-CO3/NDUFB11/COX7B/MT-CYB/NDUFB6/COX4I2/COX7C/PPARA/PRKAG2/MT-CO2/GSK3B/IL6/NDUFB1/NDUFS1/PIK3R2/NDUFV3/CYCS	6.72718917692118
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	30/1162	78/9376	3.10340262147491	ACTB/ACTG1/PTK2/VCL/CTTN/SEPTIN2/ITGB1/SEPTIN8/CRK/ARPC1B/ARHGAP10/SEPTIN6/SEPTIN11/DOCK1/ITGA5/ARPC2/BCAR1/ILK/ELMO2/SEPTIN9/SHC1/CTNNA1/DNM1/CLTCL1/SRC/DNM2/CTNNB1/ACTR3B/PIK3R2/ARPC4	7.01594691309806
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	60/1162	227/9376	2.13273484118981	MT-ND3/ATP5F1E/NDUFA4L2/UQCR11/NDUFA3/FOS/MT-ND5/NDUFB2/NDUFB3/COX7A1/UQCRQ/NDUFB7/NDUFB4/COX7A2/MT-ATP8/COX6C/COX8A/PTK2/NDUFA2/NDUFS6/CBR1/NDUFA4/PRKCD/NDUFA13/COX6B1/NDUFA6/NDUFS8/NDUFA7/NDUFA11/MAP3K5/AKT1/MT-ND6/NDUFC1/ATP5MC1/COX6A1/GSTM4/JUN/UQCR10/HIF1A/MT-CO3/NDUFB11/COX7B/MT-CYB/NDUFB6/COX4I2/COX7C/ATP5PB/MT-CO2/SRC/SLC25A5/EGFR/NDUFB1/ATP5F1A/ATP5MC3/NDUFS1/GSTO2/AHR/PIK3R2/AKR1A1/NDUFV3	6.49779082746946
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	31/1162	87/9376	2.87510633667676	CACNA2D1/UQCR11/TPM4/CACNA1C/TPM2/TPM1/COX7A1/SLC8A1/RYR2/UQCRQ/ATP1B1/COX7A2/COX6C/COX8A/COX6B1/ATP2A2/SLC9A1/COX6A1/UQCR10/MT-CO3/COX7B/MT-CYB/COX4I2/ATP2A3/COX7C/MT-CO2/TNNI3/ATP1A2/CACNB3/CACNG7/HRC	6.60864463516958
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	33/1162	99/9376	2.68961560527826	CACNA2D1/ACTB/LMNA/TGFB3/ITGA1/TPM4/SSPN/CACNA1C/TPM2/TPM1/SLC8A1/RYR2/ACTG1/SGCD/ITGA11/ITGB1/TGFB2/ITGAV/ATP2A2/IGF1/ITGA5/ATP2A3/PRKAG2/ITGB3/TNNI3/SGCB/SNTB2/CACNB3/IL6/DAG1/CACNG7/SNTB1/ITGB5	6.35642729645495
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	34/1162	105/9376	2.61276944512745	CACNA2D1/ACTB/LMNA/TGFB3/ITGA1/TPM4/SSPN/CACNA1C/TPM2/TPM1/SLC8A1/RYR2/ACTG1/SGCD/ITGA11/ITGB1/ADCY5/PRKACA/ADCY6/TGFB2/ITGAV/ATP2A2/IGF1/ITGA5/ATP2A3/ITGB3/TNNI3/SGCB/SNTB2/CACNB3/DAG1/CACNG7/SNTB1/ITGB5	6.25050344449989
NA	NA	hsa04517	IgSF CAM signaling	70/1162	299/9376	1.8890276826369	NCAM2/ACTN1/ACTB/MYL9/MYLK/NECTIN2/LRRTM4/NRP1/TUBB6/ACTN4/UNC5C/EZR/ACTG1/SORBS1/MSN/TUBA1A/PTK2/VCL/MYH11/ITGB1/MYH9/ERC1/NECTIN4/PARD6G/PLXNA4/ARPC1B/MYL6/CNTNAP2/PRKCG/NTRK3/AKT1/TUBA1B/TRPC6/GRIP2/MYH10/ROBO2/ITGA5/ARPC2/TUBB2A/LYN/PTPRS/UNC5B/VAV2/BCAR1/PTPRD/FGFR1/EPB41L1/RAPGEF2/ESAM/EPB41L2/IQGAP1/ITGB3/CADM1/CASK/APP/SRC/GSK3B/IL1RAP/MTSS1/NCK2/CTNNB1/PLXNA1/MTSS2/ANK2/ACTR3B/PIK3R2/MAGI1/ARPC4/TUBA1C/TUBB4B	5.87612551333784
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	58/1162	232/9376	2.01721170395869	ACTN1/ACTB/ITGA1/TMSB4X/CFL1/GSN/MYL9/MYLK/ENAH/ACTN4/EZR/LIMK1/ACTG1/PDGFA/MSN/PTK2/VCL/MYH11/ITGA11/ITGB1/MYH9/PFN1/F2R/CRK/ARPC1B/AKT1/ITGAV/DOCK1/SLC9A1/MYH10/ITGA5/ARPC2/MYL10/SSH2/ARHGEF1/VAV2/BCAR1/FGFR1/FGFR2/IQGAP1/ITGB3/ROCK2/SRC/CYFIP1/PIP5K1C/MRAS/GNA12/DIAPH3/EGFR/PIP5K1A/SSH1/PPP1R12A/ACTR3B/ITGB5/PIK3R2/C9/ARPC4/PPP1R12B	5.90063274759863
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	97/1162	480/9376	1.63057946069994	MT-ND3/ATP5F1E/NDUFA4L2/UQCR11/HIP1/NDUFA3/GPX7/CACNA1C/MT-ND5/NDUFB2/CALM1/NDUFB3/COX7A1/TUBB6/RYR2/UQCRQ/ACTR1A/NDUFB7/NDUFB4/WIPI1/WNT2B/COX7A2/MT-ATP8/GPX8/CAPN2/COX6C/TUBA1A/COX8A/NDUFA2/NDUFS6/NDUFA4/NDUFA13/COX6B1/NDUFA6/CAMK2G/CAPN1/WNT11/NDUFS8/NDUFA7/NDUFA11/XBP1/PRKCG/LRP5/PTGS2/MAP3K5/MT-ND6/TUBA1B/NDUFC1/ATP2A2/PINK1/ATP5MC1/COX6A1/UQCR10/MT-CO3/DCTN2/LRP6/TUBB2A/MAP1LC3A/NDUFB11/PSMD1/UBE2J1/COX7B/FZD1/MT-CYB/NDUFB6/COX4I2/ATP2A3/COX7C/PSMC4/BAK1/MTOR/IFT57/ATP5PB/MT-CO2/KLC2/APP/ATG101/SLC25A5/GSK3B/WNT3A/PSMD14/IL6/MAP1LC3C/NDUFB1/CTNNB1/MAPT/ATP5F1A/ATP5MC3/NDUFS1/MCU/AGER/PSEN2/DVL3/NDUFV3/CYCS/TUBA1C/TUBB4B	5.33426276660781
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	51/1162	204/9376	2.01721170395869	COL1A2/TIMP3/ACTB/COL1A1/THBS1/GPC3/SDC2/PLAU/CCND1/WNT2B/EZR/ACTG1/MSN/FLNA/PTK2/CTTN/ITGB1/CAMK2G/MYC/PRKACA/WNT11/PRKCG/TGFB2/AKT1/ITGAV/IGF1/SLC9A1/ITGA5/HIF1A/HSPG2/FRS2/ARHGEF1/VAV2/FZD1/FGFR1/IQGAP1/ITGB3/ROCK2/MTOR/STAT3/SRC/MRAS/WNT3A/EGFR/CTNNB1/ANK2/PPP1R12A/ITGB5/PIK3R2/RPS6KB2/PPP1R12B	5.52466262590285
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	28/1162	86/9376	2.62706640515551	CACNA2D1/ACTB/LMNA/ITGA1/SSPN/CACNA1C/DSP/SLC8A1/RYR2/ACTG1/SGCD/ITGA11/ITGB1/ITGAV/ATP2A2/ITGA5/ATP2A3/ITGB3/CTNNA1/SGCB/SNTB2/TCF7L1/CACNB3/CTNNB1/DAG1/CACNG7/SNTB1/ITGB5	5.70109134741151
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	78/1162	368/9376	1.7102447055302	MT-ND3/ATP5F1E/ACTB/NDUFA4L2/UQCR11/NDUFA3/GPX7/MT-ND5/NDUFB2/NDUFB3/COX7A1/TUBB6/UQCRQ/ACTR1A/NDUFB7/NDUFB4/WIPI1/COX7A2/MT-ATP8/ACTG1/GPX8/COX6C/CHCHD10/TUBA1A/COX8A/NDUFA2/NDUFS6/NDUFA4/NDUFA13/COX6B1/NDUFA6/PFN1/NDUFS8/NDUFA7/NDUFA11/XBP1/MAP3K5/MT-ND6/TUBA1B/NDUFC1/SEC13/PINK1/ATP5MC1/COX6A1/UQCR10/ANXA11/MT-CO3/DCTN2/TUBB2A/MAP1LC3A/NDUFB11/POM121C/PSMD1/COX7B/MT-CYB/NDUFB6/COX4I2/COX7C/PSMC4/MTOR/ATP5PB/MT-CO2/SLC1A2/NUP188/NUP153/KLC2/ATG101/PSMD14/MAP1LC3C/NDUFB1/ATP5F1A/ATP5MC3/NDUFS1/MCU/NDUFV3/CYCS/TUBA1C/TUBB4B	5.22792174970706
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	51/1162	212/9376	1.94109050758289	ACTB/THBS1/VASP/CALM1/ENAH/TLN1/DOCK4/ACTG1/PDGFA/ITGB1/ADCY5/TEK/PFN1/F2R/CRK/ID1/PARD6G/SIPA1L1/RASGRP2/SIPA1L2/ADCY6/GNAI2/PRKCG/AKT1/RAP1GAP/IGF1/ANGPT1/RAPGEF5/MAGI3/SIPA1L3/FARP2/PGF/VAV2/BCAR1/FGFR1/FGFR2/RAPGEF2/ITGB3/TLN2/EPHA2/SRC/MRAS/EGFR/NGF/CTNNB1/NGFR/RAPGEF1/SIPA1/PIK3R2/MAGI1/ARAP3	5.21276487267375
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	28/1162	89/9376	2.53851360498172	COL1A2/COL4A1/COL4A2/COL1A1/THBS1/COL6A3/ITGA1/LAMB3/COMP/COL6A2/TNC/THBS2/LAMA4/ITGA11/ITGB1/COL6A1/FRAS1/ITGAV/COL4A5/ITGA5/HSPG2/ITGB3/GP1BB/THBS3/SPP1/AGRN/DAG1/ITGB5	5.48491592039798
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	43/1162	170/9376	2.04094360635821	ACTN1/ACTB/VASP/MYL9/CGNL1/ACTN4/CLDN1/CCND1/EZR/ACTG1/MSN/TUBA1A/CTTN/MYH11/ITGB1/MYH9/PRKACA/LLGL1/PARD6G/RAB13/ARPC1B/MYL6/MAP3K5/TUBA1B/RUNX1/SYNPO/MYH10/JUN/ARPC2/RAPGEF2/PRKAG2/ROCK2/SRC/PPP2CA/PPP2R2D/ARHGAP17/ACTR3B/PCNA/MAGI1/ARPC4/TUBA1C/AMOTL2/CLDN16	5.1514267688541
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	39/1162	154/9376	2.04340925855556	CACNA2D1/ACTB/GUCY1A1/GUCY1A2/CACNA1C/MYL9/MYLK/FOS/GUCY1B1/CALM1/RYR2/RCAN1/CCND1/ACTG1/ADCY5/CAMK2G/PRKACA/MYL6/ADCY6/GNAI2/PRKCG/PTGS2/NFATC4/JUN/CAMKK2/CAMK1D/PRKAG2/ROCK2/NFATC2/SRC/MAP2K5/NFATC1/CACNB3/EGFR/MEF2C/CACNG7/PPP1R12A/KCNJ14/PPP1R12B	4.91036573447353
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	39/1162	157/9376	2.00436322176787	ACTB/TGFB3/SERPINE1/YWHAB/CCND1/WNT2B/ACTG1/BMP7/MYC/LLGL1/WNT11/ID1/PARD6G/WWC1/NKD2/TGFB2/TEAD4/LATS2/BMPR2/CCND2/SNAI2/SMAD7/FZD1/YWHAZ/CTNNA1/TP53BP2/YWHAH/TGFBR2/TCF7L1/GSK3B/WNT3A/PPP2CA/CTNNB1/PPP2R2D/TEAD1/TEAD3/DVL3/FRMD6/TGFBR1	4.77320484548079
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	68/1162	333/9376	1.64769244287317	COL1A2/COL4A1/COL4A2/HEYL/COL1A1/THBS1/NOTCH3/COL6A3/ITGA1/LAMB3/CREB3L2/COMP/COL6A2/CCND1/WNT2B/TNC/HES4/PTK2/THBS2/LAMA4/ITGA11/PKM/ITGB1/COL6A1/PRKACA/LLGL1/WNT11/PARD6G/HLA-B/JAG1/PTGS2/AKT1/ITGAV/PPP2R5B/COL4A5/TUBG1/ITGA5/CCND2/HEY2/FZD1/HLA-F/IRF1/BAK1/ITGB3/MTOR/ATP6V0D1/STAT2/CDK6/TCF7L1/GSK3B/WNT3A/THBS3/EGFR/SPP1/PPP2CA/CTNNB1/PPP2R2D/ISG15/IFNAR2/ITGB5/DVL3/PIK3R2/MAGI1/ATR/CHD4/RPS6KB2/ATP6V1E2/CREB3	4.52632812779332
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	55/1162	253/9376	1.75409713387712	ACTN1/ACTB/MYL9/ACTN4/TLN1/WIPI1/ACTG1/CAPN2/PTK2/VCL/CTTN/HK1/PRKCD/SEPTIN2/ITGB1/SEPTIN8/PFN1/CAPN1/CRK/FOXO6/ARPC1B/SEPTIN6/AKT1/SEPTIN11/DOCK1/JUN/ITGA5/ARPC2/MAP1LC3A/CAPNS1/MYL10/BCAR1/ILK/ELMO2/SEPTIN9/ROCK2/MTOR/HK2/TLN2/CYTH3/SRC/GSK3B/TECPR1/TNIP1/MAP1LC3C/EGFR/RBX1/UBE2V1/UBE2N/ACTR3B/PIK3R2/ARPC4/RPS6KB2/CYCS/RIPK2	4.57330394943049
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	32/1162	122/9376	2.11641883694027	ACTB/NOTCH3/ATP1B1/RCAN1/CCND1/SLCO1C1/ACTG1/MYC/PRKACA/PFKL/PRKCG/AKT1/ITGAV/ATP2A2/SLC9A1/HIF1A/MED27/SLC16A2/SIN3A/ATP2A3/MED24/TBC1D4/ITGB3/MTOR/PFKP/ATP1A2/SRC/GSK3B/CTNNB1/HDAC3/MED14/PIK3R2	4.66824538241147
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	45/1162	200/9376	1.81549053356282	ACTB/FOS/TUBB6/CLDN1/SEC24D/EZR/ACTG1/TUBA1A/CTTN/SEC24A/MYH11/MYO1B/ITGB1/MYH9/F2R/IRAK1/MYO1D/ARPC1B/TUBA1B/GAPDH/MYO1C/ARHGEF11/MYO5A/MYH10/JUN/ABCF2/ARPC2/TUBB2A/TNFRSF10B/ARHGEF1/MYO6/BAK1/ROCK2/CYTH3/SRC/CYFIP1/GNA12/IL6/NCK2/ACTR3B/ARPC4/CYCS/TUBA1C/TUBB4B/CLDN16	4.38448483567131
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	10/1162	21/9376	3.84230800754037	CSGALNACT1/XYLT1/CHST3/B3GALT6/CHPF/CHSY1/CHSY3/XYLT2/DSE/CHPF2	4.90422337532672
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	33/1162	140/9376	1.90194246373248	ACTA2/NOTCH3/SERPINE1/EGR1/MYLK/CALM1/SLC8A1/RYR2/CCND1/ADCY5/GNG5/PRKACA/JAG1/ADCY6/GNAI2/AKT1/SLC9A1/GNB4/PLAT/MAP1LC3A/APLNR/PRKAG2/MTOR/MRAS/KLF2/MAP1LC3C/SPP1/MEF2C/GNB5/APLN/RPS6KB2/TFAM/TGFBR1	4.04401020458555
Cellular Processes	Cell motility	hsa04814	Motor proteins	42/1162	194/9376	1.74686374363433	ACTA2/KIF26B/ACTB/ACTG2/TPM4/MYL9/TPM2/TPM1/TUBB6/ACTR1A/ACTG1/TUBA1A/MYH11/MYO1B/MYH9/KIFAP3/MYO1D/MYL6/MYO9B/TUBA1B/MYO1C/MYO5A/MYH10/TUBG1/DCTN2/TUBB2A/MYL10/MYO6/MYH13/TNNI3/KLC2/DYNLT3/DYNC1LI2/TNNC2/KIF21B/KIF2A/KIF7/DYNC1I2/KIF13A/TUBA1C/TUBB4B/MYO15B	3.95352920146854
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	26/1162	103/9376	2.03679628360878	COL1A2/COL4A1/ELN/COL4A2/COL1A1/COL27A1/COL6A3/COL5A2/COL5A3/COL3A1/SLC8A1/COL6A2/ATP1B1/COL5A1/COL18A1/SLC1A1/COL6A1/COL14A1/COL4A5/DPP4/SLC7A7/COL8A1/COL25A1/ATP1A2/COL21A1/MME	3.97936033968999
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	34/1162	149/9376	1.84121336737169	MT-ND3/NDUFA4L2/NDUFA3/CACNA1C/MT-ND5/NDUFB2/NDUFB3/NDUFB7/NDUFB4/MGLL/NDUFA2/NDUFS6/NDUFA4/ADCY5/NDUFA13/NDUFA6/GNG5/PRKACA/NDUFS8/NDUFA7/NDUFA11/ADCY6/GNAI2/PRKCG/PTGS2/MT-ND6/NDUFC1/GNB4/NDUFB11/NDUFB6/NDUFB1/NDUFS1/GNB5/NDUFV3	3.89296404044254
Organismal Systems	Immune system	hsa04611	Platelet activation	30/1162	126/9376	1.92115400377018	COL1A2/ACTB/COL1A1/GUCY1A1/P2RX1/GUCY1A2/VASP/MYLK/GUCY1B1/COL3A1/TLN1/ACTG1/ITGB1/ADCY5/PRKACA/F2R/PTGIR/RASGRP2/ADCY6/GNAI2/AKT1/LYN/ARHGEF1/ITGB3/ROCK2/TLN2/GP1BB/SRC/PPP1R12A/PIK3R2	3.91523652243288
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	32/1162	138/9376	1.87103694280227	ACTB/FOS/LIMK1/ACTG1/PTK2/ITGB1/IRAK1/CRK/ARPC1B/AKT1/GIT2/DOCK1/CCL2/JUN/ITGA5/ARPC2/ARHGEF1/VAV2/BCAR1/ELMO2/ROCK2/NFATC2/SRC/PIP5K1C/NFATC1/GSK3B/IL6/PIP5K1A/CD4/ACTR3B/PIK3R2/ARPC4	3.87702402379457
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/1162	248/9376	1.62678363222475	ACTB/MYL9/FOS/TUBB6/ACTR1A/ACTG1/TUBA1A/FLNA/RHOB/PFN1/MYC/IRAK1/GSDMD/ARPC1B/KPNA3/RAB5C/AKT1/TUBA1B/GAPDH/FHOD1/JUN/DCTN2/ARPC2/ANXA2/TUBB2A/MYL10/TNFRSF10B/MYO6/ELMO2/BAK1/ROCK2/CYTH3/KLC2/HSP90B1/DYNLT3/CYFIP1/TCF7L1/DYNC1LI2/DNM2/IL6/CTNNB1/VPS18/DYNC1I2/VPS39/ACTR3B/ARPC4/CYCS/RIPK2/TUBA1C/TUBB4B	3.76241783552755
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	27/1162	110/9376	1.98053512752308	SERPINE1/ELOB/HK1/TEK/CAMK2G/IFNGR2/TFRC/PFKL/LDHA/PRKCG/AKT1/GAPDH/IGF1/ANGPT1/HIF1A/MTOR/MKNK1/STAT3/HK2/PFKP/TIMP1/IL6/EGFR/RBX1/PIK3R2/RPS6KB2/ENO3	3.89067276088607
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	27/1162	110/9376	1.98053512752308	THBS1/TGFB3/LTBP1/LRRC32/BMP7/INHBA/E2F4/MYC/ID1/ID4/TFRC/TGFB2/FMOD/BMPR2/SMAD7/FST/SIN3A/TFDP1/TGFBR2/EMP3/SKI/PPP2CA/RBX1/FBN1/ID3/RPS6KB2/TGFBR1	3.89067276088607
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	23/1162	93/9376	1.99552125552903	ACTN1/ACTB/MYL9/NECTIN2/ACTN4/ACTG1/SORBS1/VCL/NECTIN4/SNAI2/FARP2/MYL10/FGFR1/IQGAP1/ROCK2/CTNNA1/TGFBR2/SRC/TCF7L1/EGFR/CCM2/CTNNB1/TGFBR1	3.62876788358509
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1162	71/9376	2.1592688662093	IDH2/PGAM1/TIGAR/HK1/PKM/MYC/PFKL/LDHA/NTRK3/AKT1/HIF1A/FGFR1/FGFR2/MTOR/HK2/PFKP/EGFR/PIK3R2/SIRT6	3.68779279114496
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	30/1162	134/9376	1.80645824235107	ACTA2/PPP1R14A/CALD1/GUCY1A1/ACTG2/GUCY1A2/CACNA1C/MYL9/MYLK/GUCY1B1/CALM1/PLA2G5/MYH11/PRKCD/ADCY5/MYH9/PRKACA/PTGIR/MYL6/ADCY6/PRKCG/ARHGEF11/EDNRA/MYH10/PLA2G2A/ARHGEF1/ROCK2/GNA12/PPP1R12A/PPP1R12B	3.53641036676813
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	38/1162	184/9376	1.66639227718327	EPHA5/CFL1/MYL9/SEMA4A/ENAH/NRP1/UNC5C/LIMK1/BMP7/SEMA5A/PTK2/ITGB1/SEMA3G/CAMK2G/PARD6G/PLXNA4/SEMA5B/GNAI2/TRPC6/NFATC4/ROBO2/BMPR2/SSH2/UNC5B/SEMA6B/ILK/ROCK2/NFATC2/EPHA2/SRC/EFNB1/GSK3B/NCK2/PLXNA1/SSH1/EPHB3/ABLIM2/PIK3R2	3.43356451528582
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	48/1162	250/9376	1.54921858864028	RAB31/GBF1/EHD4/EHD2/PARD6G/SMAP1/TFRC/HLA-B/ARPC1B/HSPA8/CHMP1A/RAB5C/GIT2/GRK5/VPS36/ARFGAP1/ARF4/RAB11B/ARPC2/VPS45/EPN2/HLA-F/FGFR2/AGAP1/EHD1/AP2S1/CYTH3/DNM1/CLTCL1/ARF5/TGFBR2/SRC/PIP5K1C/DNM2/EGFR/SH3KBP1/ARF3/PIP5K1A/DAB2/RAB35/SNX32/ACAP3/ACTR3B/ARPC4/ARAP3/AP2A2/TGFBR1/LDLRAP1	3.31044481697395
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	36/1162	174/9376	1.6694165825865	ERLEC1/CKAP4/SEC24D/CAPN2/SSR4/RRBP1/SEC24A/SEC62/P4HB/CAPN1/SEC61B/PPP1R15A/XBP1/HSPA8/MAP3K5/DNAJC10/SEC23A/SEC13/TMEM258/UBE2J1/SEC61G/SEC31A/BAK1/HSP90B1/KRTCAP2/EDEM2/SELENOS/MAN1A2/RPN2/DNAJC1/RBX1/OSTC/CALR/ERO1A/SEC23B/ERO1B	3.35228805073565
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1162	24/9376	3.02581755593804	EXT1/XYLT1/NDST1/EXTL2/EXTL3/B3GALT6/XYLT2/HS6ST1/EXT2	3.73736105039309
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	35/1162	170/9376	1.66123316796598	ACTB/TGFB3/SMARCA4/CCND1/WNT2B/ACTG1/MYC/WNT11/PRKCG/TGFB2/LRP5/AKT1/SMARCD3/GSTM4/LRP6/SMARCD1/FZD1/SMARCD2/BAK1/SHC1/MTOR/DPF1/TGFBR2/SMARCB1/CDK6/TCF7L1/GSK3B/WNT3A/EGFR/CTNNB1/GSTO2/DVL3/PIK3R2/RPS6KB2/TGFBR1	3.27231390933006
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/1162	116/9376	1.80853463113538	IDH2/PGP/PGAM1/HK1/PKM/CPS1/PFKL/GAPDH/DLST/PHGDH/RGN/PC/FH/GOT1/SDSL/HK2/PFKP/PGLS/GPI/OGDH/ME2/ACO2/PGD/GOT2/MDH2/ENO3	3.29559230830409
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/1162	116/9376	1.80853463113538	THY1/ACTN1/ACTB/VASP/MYL9/ACTN4/CLDN1/EZR/ACTG1/MSN/PTK2/VCL/ITGB1/GNAI2/PRKCG/MYL10/VAV2/BCAR1/ESAM/ROCK2/CTNNA1/CTNNB1/CD99L2/SIPA1/PIK3R2/CLDN16	3.29559230830409
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	34/1162	166/9376	1.65265537191796	PDE3A/GUCY1A1/GUCY1A2/CACNA1C/VASP/MYL9/MYLK/GUCY1B1/CREB3L2/CALM1/SLC8A1/ATP1B1/ADCY5/SRF/ADRA2A/ADCY6/GNAI2/AKT1/ATP2A2/TRPC6/NFATC4/EDNRA/PDE5A/GTF2I/ATP2A3/ROCK2/NFATC2/ATP1A2/NFATC1/SLC25A5/GNA12/MEF2C/PPP1R12A/CREB3	3.19094632424335
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	23/1162	101/9376	1.83746016598217	COL1A2/COL4A1/COL4A2/COL1A1/TGFB3/SERPINE1/EGR1/COL3A1/CCND1/THBD/PRKCD/TGFB2/AKT1/CCL2/COL4A5/JUN/STAT3/TGFBR2/NFATC1/IL6/AGER/PIK3R2/TGFBR1	3.18257934287794
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	43/1162	227/9376	1.52845996951936	CREB3L2/CALM1/CCND1/PTK2/ADCY5/MYC/GNG5/PRKACA/CRK/HLA-B/ADCY6/GNAI2/PRKCG/PTGS2/AKT1/ITGAV/CCL2/ARHGEF11/NFATC4/GNB4/ARHGEF1/BCAR1/HLA-F/BAK1/ITGB3/ROCK2/MTOR/STAT3/NFATC2/CDK6/SRC/NFATC1/GSK3B/GNA12/IL6/EGFR/CTNNB1/CALR/GNB5/PIK3R2/RPS6KB2/CYCS/CREB3	3.03144409244167
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	32/1162	157/9376	1.64460572042492	THBS1/PANX1/PTK2/CAMK2G/MAPKAPK2/CRK/RAB5C/PTGS2/ITGAV/ATP2A2/ADAM17/DOCK1/NFATC4/ANO6/HIF1A/ARG2/BCAR1/ATP2A3/ITGB3/NFATC2/NFATC1/PPARD/VPS18/XKR8/ABCA1/DNMT3A/CALR/VPS39/ITGB5/AGER/MFGE8/LIPA	3.06346855547045
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	32/1162	157/9376	1.64460572042492	TGFB3/SERPINE1/CALM1/CCND1/CAPN2/E2F4/MYC/CAPN1/MAPKAPK2/HLA-B/ZFP36L2/CHEK2/TGFB2/AKT1/NFATC4/CCND2/HIPK2/HLA-F/MTOR/RAD1/NFATC2/TGFBR2/CDK6/HIPK4/NFATC1/MRAS/SLC25A5/IL6/MCU/PIK3R2/ATR/TGFBR1	3.06346855547045
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	63/1162	362/9376	1.40424682154031	COL1A2/COL4A1/COL4A2/COL1A1/THBS1/COL6A3/ITGA1/LAMB3/CREB3L2/NR4A1/IL4R/YWHAB/COMP/COL6A2/CCND1/TNC/PDGFA/PTK2/THBS2/LAMA4/ITGA11/ITGB1/COL6A1/TEK/MYC/GNG5/F2R/AKT1/ITGAV/PPP2R5B/IGF1/COL4A5/ANGPT1/ITGA5/GNB4/CCND2/PGF/YWHAZ/FGFR1/FGFR2/ITGB3/MTOR/THEM4/EPHA2/YWHAH/HSP90B1/CDK6/GSK3B/IL6/THBS3/EGFR/SPP1/PPP2CA/NGF/PPP2R2D/NGFR/GNB5/IFNAR2/ITGB5/PIK3R2/MAGI1/RPS6KB2/CREB3	2.95021369877191
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	23/1162	103/9376	1.80178132780776	COL1A2/COL4A1/COL4A2/ACTN1/COL1A1/TGFB3/LAMB3/COL3A1/ACTN4/PTK2/VCL/LAMA4/PRKACA/PRKCG/TGFB2/RAB5C/COL4A5/ARG2/CXCL2/HSPB1/IL6/PIK3R2/C9	3.07734206557604
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/1162	27/9376	2.68961560527826	SCD5/ELOVL5/FADS2/ACOT7/HSD17B12/HSD17B4/ELOVL1/ACOT2/ELOVL6	3.30672871837154
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	14/1162	53/9376	2.13139349852239	SLC8A1/ATP1B1/PTH1R/PRKACA/ADCY6/PRKCG/VDR/AP2S1/DNM1/CLTCL1/ATP1A2/DNM2/KLK1/AP2A2	3.1065984728979
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1162	14/9376	3.45807720678633	CHST2/B4GALT2/B3GNT2/B4GALT1/ST3GAL3/ST3GAL2	3.46167723565167
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	53/1162	300/9376	1.42549627079748	CACNA2D1/TGFB3/CACNA1C/FOS/DUSP1/NR4A1/PDGFA/FLNA/MAP4K4/TEK/MYC/CACNA1G/PRKACA/MAPKAPK2/IRAK1/CRK/SRF/RASGRP2/HSPA8/PRKCG/TGFB2/MAP3K13/MAP3K5/AKT1/IGF1/ANGPT1/DUSP10/JUN/NF1/PGF/RPS6KA4/FGFR1/FGFR2/RAPGEF2/MKNK1/EPHA2/DUSP6/MAPK8IP1/TGFBR2/MAP2K5/NFATC1/MRAS/HSPB1/GNA12/IL1RAP/CACNB3/EGFR/NGF/MAPT/NGFR/MEF2C/CACNG7/TGFBR1	2.81721826133476
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1162	54/9376	2.09192324854975	SRM/DNMT1/LDHA/PHGDH/GSS/KYAT3/GOT1/SDSL/GCLM/AHCY/AHCYL1/GOT2/DNMT3A/MDH2	3.02653566743675
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/1162	196/9376	1.52320067441779	FOS/CALM1/RCAN1/CCND1/MICB/MYC/GNG5/MAPKAPK2/HLA-B/PTGS2/AKT1/NFATC4/JUN/HIF1A/GNB4/MAP1LC3A/LYN/HLA-F/BAK1/MTOR/STAT3/NFATC2/STAT2/CXCL2/CDK6/SRC/TCF7L1/NFATC1/GSK3B/IL6/MAP1LC3C/CTNNB1/ZFP36/GNB5/IFNAR2/PIK3R2/CYCS	2.78410969840838
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	41/1162	226/9376	1.46381734269569	PDE4D/PDE3A/CACNA1C/MYL9/FOS/CREB3L2/CALM1/PDE4C/RYR2/ATP1B1/PDE10A/CGA/GIP/ADCY5/SOX9/CAMK2G/PRKACA/F2R/GLI3/GABBR1/ADCY6/GNAI2/AKT1/ATP2A2/SLC9A1/HCAR2/EDNRA/JUN/VAV2/ATP2A3/PPARA/ROCK2/FXYD1/TNNI3/ATP1A2/NFATC1/HCAR3/PPP1R12A/PIK3R2/CREB3/ARAP3	2.65461784140203
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	30/1162	155/9376	1.56171228693576	ACTB/THBS1/TUBB6/COMP/ACTG1/TUBA1A/STX18/THBS2/ITGB1/MRC2/SEC61B/TFRC/HLA-B/RAB5C/TUBA1B/ITGAV/ITGA5/TUBB2A/HLA-F/SEC61G/ITGB3/ATP6V0D1/DYNC1LI2/THBS3/DYNC1I2/CALR/ITGB5/ATP6V1E2/TUBA1C/TUBB4B	2.65217462032984
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	17/1162	75/9376	1.82893861158921	IDH2/PYCR1/PGAM1/PKM/CPS1/ALDH18A1/PFKL/GAPDH/PHGDH/PC/ARG2/GOT1/SDSL/PFKP/ACO2/GOT2/ENO3	2.71081282614354
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	17/1162	75/9376	1.82893861158921	THBS1/SERPINE1/CD82/CCND1/ZMAT3/SESN3/PPP1R13L/CHEK2/IGF1/CCND2/TNFRSF10B/TP53I3/CDK6/STEAP3/ZNF385A/ATR/CYCS	2.71081282614354
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	19/1162	87/9376	1.76216194828575	TGFB3/FOS/CCND1/MYC/TGFB2/AKT1/JUN/BAK1/MTOR/TGFBR2/TCF7L1/GSK3B/EGFR/CTNNB1/MSH3/PIK3R2/RPS6KB2/CYCS/TGFBR1	2.6861716437884
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	33/1162	178/9376	1.49590980293566	DAAM1/CCND1/WNT2B/APCDD1/CAMK2G/MYC/PRKACA/WNT11/DAAM2/PRICKLE2/NKD2/PRKCG/LRP5/NFATC4/JUN/CCND2/LRP6/RUVBL1/FZD1/TLE2/CTBP2/ROCK2/NFATC2/ROR1/TCF7L1/NFATC1/GSK3B/WNT3A/PPARD/CTNNB1/RBX1/LZTS2/DVL3	2.51233382086698
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	24/1162	120/9376	1.61376936316695	CALM1/ARHGDIG/SORT1/PRKCD/CAMK2G/MAPKAPK2/IRAK1/CRK/NTRK3/MAP3K5/AKT1/MAGED1/JUN/FRS2/SHC1/IRAK3/MAP2K5/GSK3B/NGF/NGFR/RAPGEF1/PSEN2/PIK3R2/RIPK2	2.54504525659993
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1162	37/9376	2.18076940968507	HK1/PMM2/UXS1/GFPT1/GMPPB/HK2/PGM3/GPI/GMDS/GMPPA	2.70661896540331
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	23/1162	115/9376	1.61376936316695	PDE4D/EGR1/FOS/CREB3L2/PDE4C/STK39/PTH1R/ADCY5/PRKACA/ADCY6/GNAI2/PRKCG/LRP5/VDR/ARHGEF11/MMP16/LRP6/ARHGEF1/FGFR1/GNA12/EGFR/MEF2C/CREB3	2.49078669673361
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/1162	17/9376	2.84782828794168	MYH11/MYH9/TFRC/MYH10/PCDH1/DAG1	2.86802347238447
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	28/1162	148/9376	1.52653858677955	HEYL/NOTCH3/FOS/CCND1/WNT2B/MYC/WNT11/JAG1/LRP5/AKT1/IGF1/JUN/LRP6/HEY2/FZD1/FGFR1/BAK1/SHC1/MTOR/CDK6/TCF7L1/GSK3B/WNT3A/EGFR/CTNNB1/DVL3/PIK3R2/RPS6KB2	2.42839103670559
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/1162	98/9376	1.64670343180301	CFL1/GSN/VASP/LIMK1/PRKCD/CRK/ARPC1B/PRKCG/AKT1/DOCK1/ARPC2/LYN/VAV2/PIP5K1C/DNM2/PIP5K1A/ACTR3B/PIK3R2/ARPC4/RPS6KB2	2.42048487009113
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	25/1162	130/9376	1.55170131073746	COL1A2/ACTA2/COL4A1/COL4A2/COL1A1/FOS/CREB3L2/COL3A1/ADCY5/GNG5/PRKACA/ADCY6/GNAI2/AKT1/COL4A5/JUN/GNB4/SHC1/TGFBR2/SRC/EGFR/GNB5/PIK3R2/CREB3/TGFBR1	2.3823748752994
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1162	44/9376	2.01721170395869	CREB3L2/ARHGDIG/PRKACA/ADCY6/RAB5C/RAB11B/DCTN2/DYNC1LI2/NSF/DYNC1I2/CREB3	2.54367531049375
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/1162	137/9376	1.53131399424601	ACTB/LMNA/FOS/SEPTIN4/ACTG1/CAPN2/TUBA1A/CAPN1/DAB2IP/MAP3K5/AKT1/TUBA1B/CTSC/JUN/TNFRSF10B/BAK1/LMNB2/PARP1/NOL3/CTSF/NGF/CTSZ/DFFA/PIK3R2/CYCS/TUBA1C	2.35619053958097
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/1162	56/9376	1.87312515367593	CCND1/GPR161/PRKACA/GLI3/CCND2/PTCH2/IQCE/GAS1/MGRN1/GSK3B/EVC/KIF7/CSNK1G2	2.46475587340171
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	20/1162	99/9376	1.630070063805	SLC22A3/FOS/CHKB/PDGFA/SLC22A2/SLC44A1/PRKCG/AKT1/SLC44A3/JUN/HIF1A/DGKG/MTOR/PIP5K1C/EGFR/DGKA/PIP5K1A/PCYT1A/PIK3R2/RPS6KB2	2.37035840562663
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/1162	70/9376	1.72903860339316	ACTB/SSPN/CD40/CCND1/ACTG1/SGCD/EIF4G3/HLA-B/EIF4G1/HLA-F/SGCB/SNTB2/DAG1/SNTB1/CYCS	2.30265765312048
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/1162	154/9376	1.4670630574245	CACNA2D1/TPM4/CACNA1C/SCN7A/TPM2/CREB3L2/CALM1/TPM1/SLC8A1/RYR2/ATP1B1/ADCY5/CAMK2G/PRKACA/ADCY6/GNAI2/AKT1/PPP2R5B/ATP2A2/SLC9A1/ATP2A3/TNNI3/ATP1A2/CACNB3/PPP2CA/PPP2R2D/CACNG7/CREB3	2.19803534826848
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/1162	89/9376	1.63190160320254	GUCY1A1/GUCY1A2/GUCY1B1/TUBB6/PDGFA/TUBA1A/ADCY5/PRKACA/ADCY6/GNAI2/PRKCG/TUBA1B/TUBB2A/SRC/MAP2K5/EGFR/TUBA1C/TUBB4B	2.25277641504624
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1162	35/9376	2.0748463240718	TIGAR/HK1/PMM2/PFKL/GMPPB/HK2/PFKP/GMDS/GMPPA	2.3960455206729
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	28/1162	155/9376	1.45759813447338	CACNA1C/CREB3L2/NR4A1/CCND1/WNT2B/HSD3B2/ADCY5/CAMK2G/CACNA1G/PRKACA/WNT11/MRAP/ADCY6/GNAI2/PDE8A/FZD1/FH/KCNK3/CDK6/TCF7L1/GSK3B/WNT3A/EGFR/CTNNB1/PDE8B/AHR/DVL3/CREB3	2.16059037123994
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	26/1162	142/9376	1.47739448740637	ACTB/SDC2/FOS/DUSP1/CALM1/ACTG1/THBD/PDGFA/PTK2/MAP3K5/AKT1/ITGAV/CCL2/GSTM4/JUN/BMPR2/PLAT/ITGB3/HSP90B1/SRC/MAP2K5/KLF2/CTNNB1/MEF2C/GSTO2/PIK3R2	2.15594655089218
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/1162	47/9376	1.88845351008899	PKM/LDHA/PC/FH/ME2/ALDH2/ACACA/ALDH1B1/AKR1A1/MDH2/ACYP2	2.29655813125891
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/1162	30/9376	2.1516924842226	IDH2/ACLY/DLST/PC/FH/OGDH/ACO2/MDH2	2.37626912201507
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	38/1162	224/9376	1.36882222768626	TGFB3/EGR1/FOS/CREB3L2/NRP1/MSX1/TLN1/CD40/CCND1/ANAPC11/ADCY5/MYC/PRKACA/SRF/HLA-B/CHEK2/ADCY6/TGFB2/AKT1/EGR2/NFATC4/JUN/CCND2/MAD1L1/HLA-F/TLN2/NFATC2/TGFBR2/NFATC1/SLC25A5/IL6/CD4/ZFP36/CALR/PIK3R2/ATR/CREB3/TGFBR1	2.10133088166781
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/1162	67/9376	1.686027692861	PGAM1/HK1/PKM/PFKL/LDHA/GAPDH/HK2/PFKP/GPI/ALDH2/ALDH3B1/ALDH1B1/AKR1A1/ENO3	2.11952667349175
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/1162	106/9376	1.52242392751599	CREB3L2/PLAU/CCND1/PDGFA/ERG/AKT1/IGF1/SPINT1/PLAT/FGFR1/FGFR2/MTOR/ETV5/HSP90B1/TCF7L1/GSK3B/EGFR/CTNNB1/PIK3R2/CREB3	2.03445214336468
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1162	93/9376	1.56171228693576	COL4A1/COL4A2/LAMB3/CCND1/PTK2/LAMA4/ITGB1/MYC/PTGS2/AKT1/ITGAV/COL4A5/BAK1/SKP2/CDK6/BIRC7/PIK3R2/CYCS	2.04749370777065
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1162	56/9376	1.72903860339316	ST6GAL2/B4GALT2/DPM3/MGAT1/TMEM258/B4GALT1/MGAT4B/KRTCAP2/MAN1A2/RPN2/OSTC/DOLK	2.0580121556283
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1162	38/9376	1.91104266690823	HK1/PMM2/UXS1/GFPT1/GMPPB/HK2/PGM3/GPI/GMPPA	2.11648372504962
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/1162	50/9376	1.77514629948365	PYCR1/SRM/P4HA2/ALDH18A1/P4HA3/ARG2/GOT1/GAMT/ALDH2/GOT2/ALDH1B1	2.06696121575527
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1162	44/9376	1.83382882178063	B4GALT2/MGAT1/TMEM258/B4GALT1/MGAT4B/KRTCAP2/MAN1A2/RPN2/OSTC/ST3GAL3	2.08510163507479
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/1162	76/9376	1.59253555575686	ACTB/MYLK/CALM1/ATP1B1/EZR/ACTG1/ADCY5/CAMK2G/PRKACA/ADCY6/GNAI2/PRKCG/SLC9A1/HRH2/ATP1A2	1.9507027248637
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1162	109/9376	1.48052235152932	CREB3L2/SLC27A4/PRKCD/PPP1R3C/MLXIP/PYGB/GFPT1/AKT1/TBC1D4/PTPA/PPARA/PRKAG2/MTOR/STAT3/PYGM/GSK3B/IL6/PIK3R2/RPS6KB2/CREB3	1.89787940980297
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1162	28/9376	2.01721170395869	ELOVL5/ACOT7/HSD17B12/THEM4/ELOVL1/ACOT2/ELOVL6	2.02741364589393
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	35/1162	214/9376	1.31967120819728	CFL1/ELOB/FOS/CALM1/LIMK1/PTK2/GNG5/IRAK1/CRK/HLA-B/GNAI2/PRKCG/AKT1/NFATC4/JUN/GNB4/AP1S2/AP1M1/HLA-F/BAK1/WEE1/MTOR/AP1S1/NFATC2/NFATC1/APOBEC3C/CD4/RBX1/CALR/GNB5/AP1S3/PIK3R2/ATR/RPS6KB2/CYCS	1.77920757281601
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	24/1162	138/9376	1.4032777071017	CALM1/SORBS1/HK1/PPP1R3C/PRKACA/CRK/PYGB/AKT1/INPP5A/PRKAG2/SHC1/MTOR/MKNK1/HK2/PYGM/GSK3B/PPP1R3F/ACACA/PHKG1/RAPGEF1/SOCS4/PIK3R2/RPS6KB2/PRKAR1B	1.79500694157011
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1162	65/9376	1.61376936316695	CACNA1C/CREB3L2/NR4A1/HSD3B2/ADCY5/CACNA1G/PRKACA/MRAP/ADCY6/PDE8A/KCNK3/PDE8B/CREB3	1.86756219704535
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/1162	91/9376	1.50736698757353	PDE4D/PDE3A/PDE4C/PDE10A/ADCY5/PDE7B/GNG5/PRKACA/GABBR1/ADCY6/GNAI2/PRKCG/GRK5/PDE8A/GNB4/PDE8B/GNB5	1.8292088799834
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1162	59/9376	1.64112138627148	GPX7/IDH2/GPX8/SRM/GSTM4/GSS/GCLM/GGT7/GSTK1/PGD/RRM1/GSTO2	1.85797375569672
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/1162	23/9376	2.10491656065255	B4GALT2/B3GALNT2/POMGNT1/B4GALT1/CRPPA/ST3GAL3	1.99539687024544
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/1162	29/9376	1.94765267968425	WWC1/TEAD4/LATS2/TEAD1/FAT4/TEAD3/FRMD6	1.92231000174055
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1162	80/9376	1.51290877796902	PDGFA/PRKCG/AKT1/IGF1/NF1/FGFR2/SHC1/MTOR/STAT3/SRC/GSK3B/IL6/EGFR/PIK3R2/RPS6KB2	1.73279992557101
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	22/1162	128/9376	1.3868330464716	PDE4D/PDE3A/GUCY1A1/GUCY1A2/GUCY1B1/PDE4C/PAPSS2/PDE10A/ADCY5/PDE7B/ADCY6/PDE8A/PDE5A/PDE9A/NME3/NME1/IMPDH1/AK3/NT5E/RRM1/PDE8B/NME6	1.65735672657641
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	27/1162	163/9376	1.33655744802171	TGFB3/FOS/CREB3L2/YWHAB/MYC/IRAK1/PRKCG/TGFB2/AKT1/EGR2/NFATC4/JUN/HSPG2/YWHAZ/STAT3/NFATC2/TGFBR2/STAT2/SRC/NFATC1/IL6/STAT6/PCNA/PIK3R2/CYCS/CREB3/TGFBR1	1.63028609928656
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	25/1162	150/9376	1.34480780263913	TGFB3/CCND1/WNT2B/MYC/WNT11/TGFB2/LRP5/AKT1/LRP6/FZD1/FGFR2/BAK1/SHC1/MTOR/CTNNA1/TGFBR2/TCF7L1/GSK3B/WNT3A/EGFR/CTNNB1/DVL3/PIK3R2/RPS6KB2/TGFBR1	1.60113275539155
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/1162	49/9376	1.64670343180301	ST6GAL2/B4GALT2/B3GLCT/XXYLT1/GALNT16/B4GALT1/GALNT18/POGLUT1/ST3GAL3/POFUT2	1.70703949845895
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	26/1162	158/9376	1.32778491906142	TGFB3/YWHAB/CCND1/ANAPC11/E2F4/MYC/CHEK2/TGFB2/PPP2R5B/CCND2/MAD1L1/CDC7/YWHAZ/WEE1/SKP2/CDC14A/YWHAH/TFDP1/PRKDC/CDK6/HDAC8/GSK3B/PPP2CA/RBX1/PCNA/ATR	1.56282558681907
Human Diseases	Cancer: specific types	hsa05214	Glioma	14/1162	76/9376	1.4863665187064	CALM1/CCND1/PDGFA/CAMK2G/PRKCG/AKT1/IGF1/CAMK1D/BAK1/SHC1/MTOR/CDK6/EGFR/PIK3R2	1.60118069558068
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	20/1162	117/9376	1.37929005398885	ACTB/SMARCA4/ACTG1/CDK2AP1/GATAD2A/SMARCD3/RUVBL1/SMARCD1/GATAD2B/SMARCD2/CHD3/DPF1/BRD9/SMARCB1/SMARCA1/BAZ1B/CHRAC1/SRCAP/INO80/CHD4	1.55272196370005
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1162	50/9376	1.61376936316695	THBS1/TGFB3/SDC2/COMP/CD40/THBS2/TGFB2/CCL2/IL6/THBS3	1.63664261821283
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1162	63/9376	1.53692320301615	WNT2B/WNT11/GLI3/FZD1/PTCH2/BAK1/TCF7L1/GSK3B/WNT3A/KIF7/CTNNB1/DVL3	1.60823310807525
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	17/1162	97/9376	1.41412779246589	GUCY1A1/GUCY1A2/CACNA1C/FOS/GUCY1B1/CALM1/RYR2/ADCY5/CAMK2G/GNG5/CACNA1G/PRKACA/ADCY6/GNAI2/PRKCG/GNB4/GNB5	1.54198805720517
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	14/1162	77/9376	1.4670630574245	TGFB3/CCND1/RALBP1/TGFB2/AKT1/BAK1/MTOR/STAT3/TGFBR2/CDK6/EGFR/PIK3R2/RPS6KB2/TGFBR1	1.54779738867311
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/1162	77/9376	1.4670630574245	TGFB3/CCND1/MYC/CRK/TGFB2/AKT1/RUNX1/BAK1/SHC1/CTBP2/TGFBR2/CDK6/PIK3R2/TGFBR1	1.54779738867311
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/1162	51/9376	1.58212682663427	ACTB/KDELR2/ACTG1/KDELR3/PRKACA/SEC61B/SEC61G/ATP6V0D1/ERO1A/ATP6V1E2	1.56779629747072
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	18/1162	105/9376	1.38323088271453	CALM1/PRKCD/MAPKAPK2/PTGS2/AKT1/EGR2/NFATC4/KSR1/JUN/IRF1/NFATC2/STAT2/PLK3/SRC/NFATC1/MRAS/IL6/PIK3R2	1.48526248415912
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	32/1162	205/9376	1.25952730783762	ACTN1/GSN/CREB3L2/YWHAB/ACTN4/CCND1/PKM/PRKACA/MAPKAPK2/SRF/HLA-B/EGR2/JUN/CCND2/MAD1L1/LYN/YWHAZ/HLA-F/BAK1/HDAC7/SKP2/STAT3/YWHAH/ATP6V0D1/CDK6/SRC/HDAC8/SND1/HDAC3/PIK3R2/CHD4/CREB3	1.41306779462015
NA	NA	hsa04519	Cadherin signaling	59/1162	404/9376	1.17837119340161	ACTN1/ACTB/LHFPL6/VASP/DAAM1/VIM/FAT1/LIMA1/DSP/ENAH/YWHAB/ACTN4/CDH13/WNT2B/ACTG1/PSENEN/LHFPL2/PTK2/VCL/MYO1B/CDH6/WNT11/MYO1D/ARPC1B/WWC1/DAAM2/PRICKLE2/LRP5/MYO1C/PKP1/TEAD4/LATS2/LRP6/ARPC2/CIB2/VAV2/FZD1/YWHAZ/FGFR1/ROCK2/CTNNA1/PCDHGC3/YWHAH/CYFIP1/TCF7L1/MRAS/GSK3B/WNT3A/EGFR/PCDH1/CTNNB1/TEAD1/FAT4/TEAD3/ACTR3B/PSEN2/DVL3/ARPC4/AMOTL2	1.3784217622926
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1162	99/9376	1.38555955423425	NOTCH3/FOS/CCND1/PTK2/ADCY5/PRKACA/JAG1/ADCY6/AKT1/IGF1/JUN/SHC1/MTOR/SRC/EGFR/PIK3R2/RPS6KB2	1.45049635389702
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	38/1162	250/9376	1.22646471600688	ROGDI/NCOA7/SORT1/BORCS7/HYAL2/GALNS/CTSC/AP4M1/FUCA1/AP1S2/AP1M1/HGSNAT/MTOR/AP1S1/MEAK7/AP2S1/LAMTOR2/CLTCL1/ATP6V0D1/SMPD1/AP3D1/TFE3/KXD1/TELO2/ARSG/CTSF/OSBPL5/CTSZ/VPS18/BLOC1S1/ACP2/WDR7/LGMN/VPS39/AP1S3/ATP6V1E2/LIPA/AP2A2	1.36502835271569
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1162	86/9376	1.40735700276188	PTK2/CAMK2G/MYC/CRK/PRKCG/AKT1/JUN/SHC1/MTOR/SRC/GSK3B/NCK2/EGFR/PIK3R2/RPS6KB2	1.42734154942574
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/1162	59/9376	1.50436127074885	CCND1/MYC/AKT1/ILK/BAK1/CTNNA1/TCF7L1/GSK3B/EGFR/CTNNB1/PIK3R2	1.46164209228924
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	20/1162	122/9376	1.32276177308767	SCD5/CREB3L2/CCND1/RAB2A/PFKL/AKT1/PPP2R5B/IGF1/RAB11B/TBC1D1/CAMKK2/PRKAG2/MTOR/PFKP/PPP2CA/ACACA/PPP2R2D/PIK3R2/RPS6KB2/CREB3	1.34961101244483
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	20/1162	122/9376	1.32276177308767	CACNA1C/FOS/CREB3L2/JUNB/PTK2/ADCY5/PRKACA/CRK/ADCY6/GNAI2/PRKCG/AKT1/IGF1/BCAR1/SHC1/MTOR/STAT3/GSK3B/PIK3R2/CREB3	1.34961101244483
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/1162	101/9376	1.35812273137813	CREB3L2/CALM1/WNT2B/ADCY5/CAMK2G/PRKACA/WNT11/ADCY6/GNAI2/PRKCG/FZD1/TCF7L1/GSK3B/WNT3A/CTNNB1/DVL3/CREB3	1.36096503857273
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1162	10/9376	2.42065404475043	PAPSS2/SELENBP1/ETHE1	1.69052893449573
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/1162	144/9376	1.28877414419583	WNT2B/INHBA/MYC/WNT11/ID1/ID4/AKT1/IGF1/BMPR2/DLX5/FZD1/FGFR1/FGFR2/ZFHX3/STAT3/TBX3/GSK3B/WNT3A/PCGF2/CTNNB1/ID3/DVL3/PIK3R2	1.31341812915231
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1162	47/9376	1.54509832643644	CACNA1C/HK1/PKM/PRKCD/CACNA1G/MTOR/HK2/SOCS4/PIK3R2	1.40902138344623
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1162	28/9376	1.72903860339316	B4GALT2/B3GNT2/B3GALNT1/B4GALT1/ST3GAL4/ST3GAL3	1.4530532898418
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1162	16/9376	2.01721170395869	GOT1/AOC3/GOT2/ALDH3B1	1.53159792190239
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/1162	75/9376	1.39860011474469	GPX7/CREB3L2/ATP1B1/GPX8/CGA/ADCY5/PRKACA/PAX8/ADCY6/PRKCG/HSP90B1/ATP1A2/CREB3	1.30351064414848
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	17/1162	103/9376	1.33175141620574	TGFB3/SERPINE1/FOS/IRAK1/IFNGR2/GNAI2/TGFB2/AKT1/CCL2/JUN/TGFBR2/IL6/PPP2CA/PPP2R2D/CALR/PIK3R2/TGFBR1	1.27330551734814
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/1162	62/9376	1.43156959635778	HEYL/NOTCH3/PSENEN/JAG1/ADAM17/HEY2/TLE2/CTBP2/DTX3/PSEN2/DVL3	1.28230082712044
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/1162	119/9376	1.28830327311648	FOS/CREB3L2/JUNB/JAG1/DAB2IP/PTGS2/MAP3K5/AKT1/ADAM17/CCL2/JUN/RPS6KA4/IRF1/RHBDF1/RHBDF2/CXCL2/IL6/PIK3R2/CREB3	1.19041742347874
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	16/1162	98/9376	1.31736274544241	CACNA1C/CREB3L2/CALM1/NR4A1/ATP1B1/HSD3B2/ADCY5/CAMK2G/CACNA1G/PRKACA/ADCY6/PRKCG/CAMK1D/KCNK3/ATP1A2/CREB3	1.18782688616986
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1162	70/9376	1.38323088271453	TGFB3/ELOB/CRK/TGFB2/AKT1/JUN/HIF1A/FH/TFE3/RBX1/RAPGEF1/PIK3R2	1.21042907863527
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1162	57/9376	1.41558716067277	SCD5/ELOVL5/FADS2/ACADVL/HSD17B12/HSD17B4/ELOVL1/ACSL4/ACACA/ELOVL6	1.18365802461964
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1162	71/9376	1.36374875760588	FOS/CCND1/CGA/AKT1/CCND2/IRF1/SHC1/STAT3/SRC/GSK3B/SOCS4/PIK3R2	1.15713453987014
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/1162	107/9376	1.2819663165345	CREB3L2/CALM1/PGAM1/PKM/CAMK2G/PRKACA/PYGB/PFKL/LDHA/AKT1/PPARA/PRKAG2/PFKP/PYGM/ACACA/PHKG1/CREB3	1.10327564633862
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	24/1162	158/9376	1.22564761759515	WNT2B/PRR5L/WNT11/PRKCG/LRP5/AKT1/SEC13/IGF1/LRP6/CLIP1/FZD1/MTOR/SKP2/LAMTOR2/GSK3B/WNT3A/TELO2/FNIP2/DEPDC5/DVL3/PIK3R2/RPS6KB2/ATP6V1E2/LPIN2	1.07585141925458
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	18/1162	115/9376	1.26294993639153	CACNA1C/FOS/CREB3L2/ADCY5/CAMK2G/GNG5/PRKACA/ADCY6/GNAI2/PRKCG/AKT1/GNB4/SLC18A3/CHAT/GNB5/PIK3R2/CREB3/KCNJ14	1.06709823392213
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/1162	31/9376	1.56171228693576	PFKL/RGN/PFKP/PGLS/GPI/PGD	1.17819308861437
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1162	12/9376	2.01721170395869	NCAM2/NECTIN4/NGFR	1.32611938017592
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	17/1162	109/9376	1.25844399879992	FOS/IL4R/IFNGR2/RUNX1/JUN/HIF1A/MTOR/STAT3/NFATC2/TGFBR2/NFATC1/IL1RAP/IL6/STAT6/CD4/AHR/TGFBR1	1.02075489797395
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1162	32/9376	1.51290877796902	B4GALT2/HK1/PFKL/B4GALT1/HK2/PFKP	1.09310041436005
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1162	32/9376	1.51290877796902	WIPI1/ATG10/MTOR/ATG101/ATG4B/PPP2CA	1.09310041436005
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	31/1162	216/9376	1.15802894116147	FOS/CALM1/CD40/PTK2/CAMK2G/IRAK1/XBP1/HSPA8/MAP3K5/AKT1/CCL2/JUN/LYN/TNFRSF10B/ARHGEF1/VAV2/ROCK2/STAT3/NFATC2/HSPA2/HSP90B1/CXCL2/SRC/NFATC1/GSK3B/IL6/ABCA1/ERO1A/AGER/PIK3R2/CYCS	0.883745309796789
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/1162	68/9376	1.30525463197327	CCND1/MYC/AKT1/RUNX1/MTOR/STAT3/DUSP6/TCF7L1/PPARD/PIK3R2/RPS6KB2	0.950166872544729
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1162	33/9376	1.4670630574245	IDH2/DLST/GOT1/OGDH/ACO2/GOT2	1.01088247236135
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/1162	90/9376	1.25515394912985	CREB3L2/ADCY5/SESN3/PRKACA/ADCY6/AKT1/IGF1/CAMKK2/PRKAG2/MTOR/ATG101/PIK3R2/RPS6KB2/CREB3	0.914788218058363
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/1162	90/9376	1.25515394912985	BATF3/FOS/IFNGR2/AKT1/JUN/HIF1A/MTOR/STAT3/NFATC2/NFATC1/EGFR/CD4/PIK3R2/RPS6KB2	0.914788218058363
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/1162	83/9376	1.26379528440786	IDH2/CROT/DECR2/CRAT/PEX10/HSD17B4/GSTK1/ACSL4/FAR1/ACOX2/ABCD3/PEX14/PEX26	0.907903015230552
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1162	20/9376	1.61376936316695	GMPPB/CYB5R3/GMDS/GMPPA	1.03344281619713
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1162	69/9376	1.28633789817656	PDE3A/GUCY1A1/GUCY1A2/CACNA1C/GUCY1B1/CALM1/ADCY5/PRKACA/ADCY6/GNAI2/EDNRA	0.897862584518381
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1162	69/9376	1.28633789817656	FOSB/CACNA1C/FOS/CREB3L2/CALM1/ADCY5/CAMK2G/PRKACA/PRKCG/JUN/CREB3	0.897862584518381
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1162	62/9376	1.3014269057798	ADCY5/PRKACA/HSPA8/ADCY6/AKT1/IGF1/PRKAG2/MTOR/PIK3R2/RPS6KB2	0.89561445908103
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1162	41/9376	1.3776079929474	PGAM1/PHGDH/SDSL/ALAS1/AOC3/GAMT/SARDH	0.911354408548572
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1162	41/9376	1.3776079929474	THBS1/CCND1/MYC/TYMP/DAPK3/SRC/EGFR	0.911354408548572
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/1162	99/9376	1.22255254785375	CALM1/TRPV2/PRKCD/ADCY5/CAMK2G/PRKACA/ADCY6/PRKCG/IGF1/F2RL1/SRC/TRPA1/IL1RAP/NGF/PIK3R2	0.837254986077274
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1162	49/9376	1.31736274544241	FOSB/CREB3L2/ADCY5/PRKACA/GNAI2/JUN/RGS9/CREB3	0.837711252434774
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1162	21/9376	1.53692320301615	ALDH2/COASY/PPCDC/ALDH1B1	0.926427155678229
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1162	42/9376	1.34480780263913	TFRC/GSS/MAP1LC3A/GCLM/ACSL4/MAP1LC3C/STEAP3	0.842324018888966
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	24/1162	169/9376	1.14587173715997	WIPI1/PRKCD/ATG10/VMP1/PRKACA/DAPK3/AKT1/HIF1A/WDR45B/GORASP2/MAP1LC3A/CAMKK2/GORASP1/MTOR/ATG101/MRAS/ATG4B/MTMR4/MAP1LC3C/PPP2CA/VPS18/VPS39/PIK3R2/RPS6KB2	0.71972533184031
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	22/1162	154/9376	1.15269240226211	MTHFD1L/CTPS1/PMM2/RDH11/GMPPB/ALPL/RGN/GSS/NME3/GGH/NME1/ALAS1/GCLM/AK3/ALDH2/GMPPA/COASY/TDO2/NME6/PPCDC/ALDH1B1/AKR1A1	0.718582410338453
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1162	79/9376	1.22564761759515	SLC1A1/SLC18A3/SLC6A1/AP2S1/DNM1/CLTCL1/SLC1A2/ATP6V0D1/NSF/DNM2/ATP6V1E2/AP2A2	0.757502788166531
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1162	65/9376	1.24136104858996	LIPG/MGLL/AGPAT4/LCLAT1/DGKG/ALDH2/DGKA/ALDH1B1/AKR1A1/LPIN2	0.734407413006098
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1162	36/9376	1.34480780263913	HK1/PYGB/HK2/GPI/PYGM/GYG1	0.779589982865075
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	30/1162	217/9376	1.11550877638269	CACNA1C/FOS/CREB3L2/CCND1/ADCY5/MYC/PRKACA/JAG1/KPNA3/ADCY6/GNAI2/PRKCG/AKT1/VDR/GSTM4/JUN/PPARA/KLF5/MTOR/STAT3/HSP90B1/SRC/KPNA2/EGFR/KPNB1/GSTO2/AHR/PIK3R2/RPS6KB2/CREB3	0.647488670425376
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	19/1162	133/9376	1.15269240226211	CACNA1C/FOS/CREB3L2/CALM1/ADCY5/CAMK2G/GNG5/PRKACA/GNAI2/PRKCG/AKT1/PPP2R5B/GNB4/CALY/GSK3B/PPP2CA/PPP2R2D/GNB5/CREB3	0.667034235612893
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	20/1162	142/9376	1.1364572980049	ELOB/CUL7/ANAPC11/TRIM37/UBE2E2/FBXW7/UBE2J1/SKP2/HERC2/MGRN1/RHOBTB2/UBE2E3/FBXW8/UBE2O/RBX1/BIRC7/UBE2Q2/UBE2N/MID1/PIAS3	0.61625060351252
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/1162	59/9376	1.23084103970361	CTPS1/TYMP/TK2/NME3/NME1/UPP1/NT5E/RRM1/NME6	0.668978765474274
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1162	59/9376	1.23084103970361	MGLL/CGA/ADCY5/PRKACA/ADCY6/GNAI2/PTGS2/AKT1/PIK3R2	0.668978765474274
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1162	37/9376	1.30846164581104	GOT1/AOC3/FAHD1/GOT2/ALDH3B1/FAH	0.707071282338152
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1162	37/9376	1.30846164581104	CCND1/MYC/PAX8/BAK1/TCF7L1/CTNNB1	0.707071282338152
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1162	89/9376	1.17859560231294	CACNA1C/ADCY5/GNG5/PRKACA/GABBR1/ADCY6/GNAI2/PRKCG/GNB4/SLC6A1/SRC/NSF/GNB5	0.636706662370377
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1162	52/9376	1.24136104858996	CGA/HSD3B2/ADCY5/PRKACA/ADCY6/PTGS2/IGF1/ACOT2	0.656415876021079
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1162	23/9376	1.4032777071017	CPS1/ARG2/GOT1/GOT2	0.728289450304955
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1162	16/9376	1.51290877796902	B3GALNT1/GBGT1/ST3GAL2	0.772277801568379
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1162	45/9376	1.25515394912985	ABCC3/ABCC10/ABCA7/ABCD3/ABCA1/ABCB8/DEFB1	0.645291299648311
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1162	60/9376	1.21032702237521	PTK2/MAPKAPK2/PRKCG/PTGS2/AKT1/NFATC2/SRC/HSPB1/PIK3R2	0.614705801216009
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1162	60/9376	1.21032702237521	GUCY1A1/GUCY1A2/GUCY1B1/GNAI2/PRKCG/IGF1/LYN/GNA12/PPP2CA	0.614705801216009
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1162	38/9376	1.27402844460549	ATP1B1/PRKCG/IGF1/ATP1A2/HSD11B2/PIK3R2	0.636607663147568
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/1162	31/9376	1.3014269057798	SRP19/SEC62/SEC61B/SRPRA/SEC61G	0.632243775633824
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1162	17/9376	1.42391414397084	FMO1/ADO/GGT7	0.657959250390322
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1162	17/9376	1.42391414397084	PAPSS2/KYAT3/SEPHS1	0.657959250390322
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	26/1162	193/9376	1.08699490783266	PTK2/PRKCD/ADCY5/GNG5/PRKACA/CRK/RASGRP2/ADCY6/GNAI2/AKT1/GRK5/CCL2/GNB4/LYN/VAV2/BCAR1/SHC1/ROCK2/STAT3/STAT2/CXCL2/SRC/GSK3B/GNB5/PIK3R2/CCL26	0.459294820256678
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1162	32/9376	1.26075731497418	SEPTIN4/BAK1/NGFR/BIRC7/CYCS	0.555720512669625
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	12/1162	86/9376	1.1258856022095	CACNA1C/CREB3L2/RYR2/ATP1B1/GIP/ADCY5/CAMK2G/PRKACA/ADCY6/PRKCG/ATP1A2/CREB3	0.441091596044409
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	21/1162	156/9376	1.08619091751622	YWHAB/CLDN1/CCND1/MYC/AKT1/YWHAZ/PPARA/BAK1/STAT3/YWHAH/STAT2/CDK6/GSK3B/EGFR/PPP2CA/CTNNB1/PPP2R2D/IFNAR2/PIK3R2/CYCS/CLDN16	0.408290895325154
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/1162	63/9376	1.15269240226211	POLR2L/CETN2/ERCC1/ERCC4/RFC1/GTF2H5/POLR2J/RBX1/PCNA	0.457355866332498
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	20/1162	149/9376	1.08306668668923	PTGFR/PDGFA/AGPAT4/ADCY5/F2R/ADCY6/AKT1/SHC1/DGKG/MTOR/CYTH3/DNM1/PIP5K1C/MRAS/GNA12/DNM2/EGFR/DGKA/PIP5K1A/PIK3R2	0.384415698540603
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/1162	142/9376	1.07963443310465	FOSB/FOS/JUNB/FHL2/IFNGR2/TGFB2/AKT1/TNFRSF11B/ATP2A2/JUN/ATP2A3/ITGB3/NFATC2/TGFBR2/STAT2/NFATC1/IFNAR2/PIK3R2/TGFBR1	0.359634612282577
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	31/1162	238/9376	1.05098424912134	CALM1/PDGFA/PLA2G5/RALBP1/TEK/GNG5/PRKACA/RASGRP2/PRKCG/RAB5C/AKT1/IGF1/ANGPT1/KSR1/RGL2/GNB4/NF1/RAPGEF5/PLA2G2A/PGF/RASAL2/FGFR1/FGFR2/SHC1/EPHA2/MRAS/EGFR/NGF/NGFR/GNB5/PIK3R2	0.299647240236803
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	33/1162	254/9376	1.04831474378956	P2RX1/CACNA1C/PTGFR/MYLK/CALM1/SLC8A1/RYR2/PDGFA/CAMK2G/CACNA1G/PRKACA/F2R/ORAI2/PRKCG/NTRK3/ATP2A2/NFATC4/EDNRA/ATP2A3/FGFR1/CAMK1D/FGFR2/HRH2/NFATC2/NFATC1/TNNC2/SLC25A5/EGFR/NGF/PHKG1/MCU/HRC/ITPKC	0.293604601781564
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	14/1162	104/9376	1.08619091751622	CHKB/PLA2G5/AGPAT4/SGMS2/LCLAT1/PLA2G2A/CHAT/DGKG/PISD/LPGAT1/DGKA/PCYT1A/PLD3/LPIN2	0.332431994316312
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/1162	144/9376	1.06463951042264	SCD5/CCND1/IRAK1/MAP3K5/AKT1/IL17RC/ACADVL/CAMKK2/PPARA/PRKAG2/CXCL2/TCF7L1/ALDH2/GSK3B/IL6/CTNNB1/ACACA/ALDH1B1/LPIN2	0.293996905730783
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1162	19/9376	1.27402844460549	HYAL2/GALNS/HGSNAT	0.449692334238238
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/1162	66/9376	1.10029729306838	TGFB3/IL4R/IFNGR2/TGFB2/JUN/STAT3/NFATC1/IL6/STAT6	0.307537225666377
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	26/1162	201/9376	1.04373142891395	PLAU/CD40/ETV6/PDGFA/PTK2/ERG/MYC/PAX8/IGF1/RUNX1/SPINT1/CCND2/PLAT/SIN3A/BAK1/DUSP6/ETV5/TGFBR2/TFE3/IL6/HMGA2/TAF15/ETV7/NGFR/MEF2C/NR4A3	0.235721943562836
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1162	139/9376	1.04488663802177	FOS/CREB3L2/CALM1/PRKCD/ADCY5/PRKACA/GABBR1/HSPA8/ADCY6/GNAI2/AKT1/JUN/SHC1/HSP90B1/SRC/EGFR/PIK3R2/CREB3	0.200525847053748
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/1162	44/9376	1.10029729306838	TAF13/GTF2I/GTF2H5/TAF10/TAF15/TAF5L	0.250806933398938
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1162	44/9376	1.10029729306838	TDG/PNKP/RFC1/PARP1/FEN1/PCNA	0.250806933398938
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1162	76/9376	1.06169037050457	SCD5/SORBS1/SLC27A4/FADS2/ILK/PPARA/ACSL4/ACOX2/PPARD/FABP5	0.203092578448583
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	26/1162	205/9376	1.02336593761807	VIM/CD40/CCND1/MYC/IRAK1/HLA-B/AKT1/JUN/CCND2/LYN/PSMD1/SIN3A/HLA-F/PSMC4/BAK1/SKP2/STAT3/STAT2/CDK6/PSMD14/IL6/ISG15/CALR/IFNAR2/PIK3R2/CYCS	0.127222272732292
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/1162	133/9376	1.03135635991873	TGFB3/CCND1/FOXO6/TGFB2/AKT1/IGF1/CCND2/PRKAG2/SKP2/STAT3/TGFBR2/PLK3/KLF2/IL6/EGFR/PIK3R2/TGFBR1	0.136979740053398
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/1162	125/9376	1.03281239242685	S1PR3/S1PR5/SGMS2/GNAI2/PRKCG/MAP3K5/AKT1/PPP2R5B/DEGS1/ROCK2/ORMDL2/SMPD1/GNA12/PPP2CA/PPP2R2D/PIK3R2	0.138902453176072
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1162	93/9376	1.04114152462384	CACNA1C/EGR1/CALM1/PRKCD/CGA/ADCY5/CAMK2G/PRKACA/ADCY6/JUN/SRC/EGFR	0.149964696793323
Organismal Systems	Digestive system	hsa04970	Salivary secretion	12/1162	93/9376	1.04114152462384	GUCY1A1/GUCY1A2/GUCY1B1/CALM1/ATP1B1/ADCY5/PRKACA/ADCY6/PRKCG/SLC9A1/ATP1A2/CST3	0.149964696793323
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/1162	85/9376	1.04420370557862	CTPS1/TYMP/TK2/NME3/NME1/IMPDH1/UPP1/AK3/NT5E/RRM1/NME6	0.153974308870633
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1162	37/9376	1.09038470484254	CPS1/GFPT1/RIMKLB/GOT1/GOT2	0.207184361571864
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1162	37/9376	1.09038470484254	LAMA4/PRKCG/THOP1/F2RL1/IL6	0.207184361571864
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1162	13/9376	1.24136104858996	PRKDC/FEN1	0.327523677271972
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1162	78/9376	1.03446754049164	CFL1/FOS/CALM1/ITGB1/IRAK1/GNAI2/JUN/ITGA5/IRF1/IL6	0.114967259166396
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/1162	46/9376	1.05245828032627	PSME4/PSMD1/PSMC4/PSME2/PSMD14/PSMB10	0.134141604425259
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/1162	168/9376	1.00860585197935	IL4R/CCND1/PDGFA/MYC/IFNGR2/IL11RA/AKT1/CCND2/IL24/MTOR/STAT3/IL13RA1/STAT2/IL6/EGFR/STAT6/IFNAR2/SOCS4/PIK3R2/PIAS3/IL19	0.0423328210244274
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	20/1162	160/9376	1.00860585197935	NCAM2/SDC2/NECTIN2/CLDN1/CD40/VCAN/ITGB1/SDC3/HLA-B/CNTNAP2/ITGAV/CD276/PTPRS/HLA-F/PTPRD/ESAM/CADM1/CD4/CD99L2/CLDN16	0.0412946684156008
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/1162	136/9376	1.00860585197935	FOS/CCND1/MSN/IRAK1/HSPA8/AKT1/JUN/CCND2/BAK1/STAT3/STAT2/CDK6/GSK3B/IL6/IFNAR2/PIK3R2/CYCS	0.0380223270823172
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1162	22/9376	1.10029729306838	ALDH2/ALDH3B1/ALDH1B1	0.177138605962277
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1162	63/9376	1.02461546867743	PLA2G5/CBR1/PTGR1/PTGS2/PLA2G2A/PTGES2/PRXL2B/LTC4S	0.0737301190849132
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/1162	112/9376	1.00860585197935	TGFB3/LAMB3/CD40/LAMA4/ITGB1/IRAK1/IFNGR2/HSPA8/GNAI2/TGFB2/AKT1/STAT3/BIRC7/CYCS	0.0344599753980737
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/1162	88/9376	1.00860585197935	F5/SERPINE1/CFI/PLAU/THBD/CFH/A2M/PROCR/F2R/PLAT/C9	0.0305060134654673
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/1162	105/9376	0.999000081960495	CCZ1/ARIH1/RAB5C/PINK1/RABGEF1/JUN/HIF1A/MAP1LC3A/SRC/MRAS/TFE3/MTX1/MAP1LC3C	-0.00387531594737625
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1162	31/9376	1.04114152462384	RGN/ALDH2/ALDH1B1/AKR1A1	0.0862944626532812
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1162	31/9376	1.04114152462384	AOC3/ALDH2/ALDH3B1/ALDH1B1	0.0862944626532812
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1162	23/9376	1.05245828032627	RFC1/MSH3/PCNA	0.0947357403347139
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1162	23/9376	1.05245828032627	THOP1/MME/KLK1	0.0947357403347139
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1162	23/9376	1.05245828032627	ATP1B1/ATP1A2/SLC25A10	0.0947357403347139
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/1162	48/9376	1.00860585197935	OXCT1/ALDH2/IVD/AACS/ALDH1B1/MCCC2	0.0224818256201787
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1162	48/9376	1.00860585197935	CLDN1/CHMP1A/DPP4/HSPG2/EGFR/CLDN16	0.0224818256201787
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1162	48/9376	1.00860585197935	ATP1B1/HK1/AKT1/HK2/ATP1A2/PIK3R2	0.0224818256201787
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/1162	73/9376	0.994789333459081	MAP1B/MAP1A/AFF4/BICD1/ELL/NUP153/SMARCB1/APOBEC3C/CD4	-0.0168094906417876
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/1162	73/9376	0.994789333459081	CCND1/PDGFA/AKT1/IGF1/FGFR1/BAK1/CDK6/EGFR/PIK3R2	-0.0168094906417876
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1162	98/9376	0.988022059081808	CALM1/PRKCG/ITPK1/INPP5A/DGKG/PIP5K1C/MTMR4/DGKA/PIP5K1A/IP6K2/PIK3R2/ITPKC	-0.0448310977514027
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/1162	65/9376	0.993088838871971	CACNA1C/CGA/CACNA1G/GABBR1/PRKCG/AKT1/SPP1/PIK3R2	-0.021029109686735
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/1162	82/9376	0.984005709248142	TYMP/GSTM4/TK2/NME3/NME1/IMPDH1/UPP1/RRM1/NME6/GSTO2	-0.0547119169709629
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/1162	83/9376	0.972150218775273	CBX6/BCORL1/YAF2/TFDP1/FOXK2/SFMBT1/RING1/PCGF2/E2F6/HCFC1	-0.0958504637571445
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	9/1162	75/9376	0.968261617900172	MAP3K5/AKT1/ERCC1/GSTM4/BAK1/MSH3/GSTO2/PIK3R2/CYCS	-0.103791537846586
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1162	42/9376	0.960577001885091	DLST/KYAT3/ALDH2/TDO2/ALDH1B1	-0.0963056460864258
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/1162	102/9376	0.949276095980561	RYR2/ATP1B1/PLA2G5/ADCY5/ADCY6/PRKCG/SCT/ATP2A2/SLC9A1/PLA2G2A/ATP2A3/ATP1A2	-0.193727183785561
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	17/1162	144/9376	0.952572193536049	WIPI1/XBP1/PRKCG/MAP3K5/AKT1/ATP2A2/PSMD1/ATP2A3/PSMC4/MTOR/KCND3/ATG101/SLC25A5/PSMD14/MCU/PIK3R2/CYCS	-0.215713705979983
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/1162	94/9376	0.944226755044494	FOSB/FOS/PTGS2/CCL2/IL17RC/JUN/HSP90B1/CXCL2/GSK3B/IL6/IL17B	-0.204399773747149
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1162	43/9376	0.938238001841252	PLA2G5/SLC27A4/PLA2G2A/ABCA1/GOT2	-0.152670907085677
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/1162	52/9376	0.931020786442473	LIPG/SORT1/OSBPL5/ABCA1/LIPA/LDLRAP1	-0.187598832368065
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1162	17/9376	0.949276095980561	HSD17B4/ACOX2	-0.0787288236077266
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1162	26/9376	0.931020786442473	PLA2G5/FADS2/PLA2G2A	-0.132467841612637
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/1162	95/9376	0.934287526044026	TGFB3/FOS/TEK/TGFB2/CCL2/ANGPT1/JUN/ATP6V0D1/CXCL2/IL6/ATP6V1E2	-0.24211605399881
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/1162	61/9376	0.925933241161367	ATOX1/SLC8A1/ATP1B1/SLC39A4/VDR/HMOX2/ATP1A2	-0.21827710302898
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/1162	71/9376	0.909165838403918	ADAM17/JUN/LYN/ATP6V0D1/CXCL2/SRC/EGFR/ATP6V1E2	-0.288955889429752
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1162	27/9376	0.896538535092752	OXCT1/ACSM6/AACS	-0.202483331821053
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1162	36/9376	0.896538535092752	GALNT16/GALNT18/B4GALT5/ST3GAL2	-0.233920233349976
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1162	18/9376	0.896538535092752	ACSL4/ACACA	-0.165247427905532
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1162	28/9376	0.864519301696582	CBR1/ALPL/GGH	-0.270027778314614
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/1162	116/9376	0.904267315567689	CACNA1C/SLC1A1/ADCY5/GNG5/PRKACA/GRIK4/ADCY6/GNAI2/PRKCG/GNB4/SLC1A2/GNB5/SHANK3	-0.390207031732695
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/1162	73/9376	0.884257185296961	CCND1/PRKCG/AKT1/BAK1/STAT3/CDK6/EGFR/PIK3R2	-0.373383663169845
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1162	19/9376	0.84935229640366	DLST/OGDH	-0.247219289863865
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/1162	100/9376	0.887573149741824	ITGA1/IL4R/TFRC/IL11RA/CD7/ITGA5/ITGB3/GP1BB/IL6/MME/CD4	-0.42510971175044
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1162	29/9376	0.834708291293252	CALM1/GUCA1B/RGS9	-0.335293627785272
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	34/1162	298/9376	0.920606683685846	TGFB3/TNFRSF12A/TNFSF15/IL4R/CD40/BMP7/INHBA/IFNGR2/IL32/IL11RA/RELL1/TGFB2/TNFRSF11B/CCL2/IL17RC/BMPR2/IL24/TNFRSF10B/TNFRSF10D/IL33/IL13RA1/TGFBR2/CXCL2/ACVRL1/IL1RAP/IL6/NGF/CD4/NGFR/IFNAR2/IL17B/CCL26/TGFBR1/IL19	-0.523851677432659
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1162	20/9376	0.806884681583477	SQLE/LIPA	-0.325160639308237
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1162	39/9376	0.82757403239331	MTHFD1L/AHCY/AHCYL1/SARDH	-0.405828599094688
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/1162	93/9376	0.867617937186534	NOTCH3/FOS/IL4R/IFNGR2/JAG1/JUN/NFATC2/NFATC1/STAT6/CD4	-0.482544973532452
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1162	30/9376	0.806884681583477	GPAA1/PIGQ/PIGX	-0.398451821495602
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1162	30/9376	0.806884681583477	ABCC3/GGH/IL6	-0.398451821495602
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	15/1162	138/9376	0.877048566938562	CALM1/YWHAB/ANAPC11/ADCY5/CAMK2G/PRKACA/ADCY6/PPP2R5B/IGF1/MAD1L1/CPEB4/YWHAZ/YWHAH/PPP2CA/RBX1	-0.547262275932399
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/1162	103/9376	0.861721504603713	NCBP2/PPP2R5B/CSTF2T/PELO/MSI2/CPSF3/UPF3A/RNGTT/PPP2CA/PPP2R2D/DDX19B	-0.530731030879759
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1162	31/9376	0.780856143467881	PGP/ACO2/MDH2	-0.459654850327261
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/1162	122/9376	0.859795152506983	FOS/AKT1/PPP2R5B/JUN/VAV2/NFATC2/NFATC1/GSK3B/NCK2/PPP2CA/CD4/PPP2R2D/PIK3R2	-0.586259036702368
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/1162	78/9376	0.82757403239331	LSM7/PFKL/MPHOSPH6/PFKP/TENT4B/LSM1/ENO3/BTG3	-0.575130706226771
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/1162	78/9376	0.82757403239331	TGFB3/FOS/ITGB1/IRAK1/IFNGR2/TGFB2/PTGS2/JUN	-0.575130706226771
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/1162	70/9376	0.806884681583477	AKT1/CAMKK2/PPARA/PRKAG2/MTOR/STAT3/ACSL4	-0.609951878840076
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1162	43/9376	0.750590401473002	ACADVL/ALDH2/ACSL4/ALDH1B1	-0.616521336390704
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1162	23/9376	0.701638853550849	PDSS1/ICMT	-0.538817969635527
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/1162	108/9376	0.821826990501689	NCBP2/KPNA3/SEC13/POM121C/NUP188/NUP153/UPF3A/KPNA2/IPO13/KPNB1/DDX19B	-0.700441926467858
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1162	90/9376	0.806884681583477	ATP1B1/ADCY5/PRKACA/ABCC3/ADCY6/SCT/SLC9A1/SLC4A5/ATP1A2	-0.692364819813622
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/1162	180/9376	0.851711608338114	NECTIN2/IRAK1/IFNGR2/HLA-B/AKT1/CCL2/ITGA5/HLA-F/BAK1/ITGB3/MTOR/STAT2/SRC/IL6/CALR/IFNAR2/PIK3R2/CYCS/HCFC1	-0.755536202681099
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/1162	91/9376	0.798017816950691	FOS/AKT1/JUN/LYN/VAV2/NFATC2/NFATC1/GSK3B/PIK3R2	-0.728205838931695
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/1162	34/9376	0.711957071985421	POLR2L/POLR2J/POLR3A	-0.632831512215479
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1162	34/9376	0.711957071985421	CRY1/PRKAG2/RBX1	-0.632831512215479
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/1162	82/9376	0.787204567398514	HLA-B/HSPA8/HLA-F/PSME2/HSPA2/CD4/LGMN/CALR	-0.727912617128115
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/1162	54/9376	0.747115445910627	ERCC1/ERCC4/TELO2/FAAP100/ATR	-0.700932161405896
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/1162	83/9376	0.777720175020219	POLR2L/GSDMD/AIM2/ZDHHC11/IL33/IL6/ZDHHC1/POLR3A	-0.765019449748942
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1162	55/9376	0.733531528712252	SGMS2/DEGS1/SMPD1/B4GALT5/CERK	-0.745430698740004
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/1162	56/9376	0.720432751413818	HSPA8/RAB1B/CXCL2/IL6/CYCS	-0.789193868785623
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1162	36/9376	0.672403901319564	RFC1/FEN1/PCNA	-0.740675341457501
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/1162	187/9376	0.819829355619575	ANTXR1/TRPV2/GBP1/PANX1/PRKCD/GSDMD/AIM2/CCL2/JUN/NLRP1/MAP1LC3A/DHX33/STAT2/CXCL2/IL6/MAP1LC3C/MCU/IFNAR2/RIPK2	-0.936013391635826
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/1162	115/9376	0.771802738905934	CACNA1C/DUSP1/ADCY5/GNG5/PRKACA/GNAI2/PRKCG/PTGS2/GNB4/APP/GNB5	-0.926065614013931
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1162	15/9376	0.537923121055651	ST3GAL2	-0.673612438599294
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1162	15/9376	0.537923121055651	ALPL	-0.673612438599294
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/1162	78/9376	0.724127278344146	ITPK1/INPP5A/PIP5K1C/MTMR4/PIP5K1A/IP6K2/ITPKC	-0.920179688923354
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1162	38/9376	0.637014222302745	NT5E/NNT/SIRT6	-0.843268398754481
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	34/1162	323/9376	0.84935229640366	TIMP3/THBS1/NOTCH3/VIM/SOX4/TPM1/PLAU/CCND1/TNC/EZR/PDGFA/DNMT1/IGF2BP1/MYC/CRK/PRKCG/TGFB2/PTGS2/MMP16/ITGA5/BMPR2/CCND2/BAK1/SHC1/ITGB3/MTOR/STAT3/RECK/CDK6/WNT3A/HMGA2/EGFR/DNMT3A/PIK3R2	-1.0362841838066
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1162	79/9376	0.71496111026384	HSD11B1/CBR1/GSTM4/GSTK1/ALDH3B1/AKR7A2/GSTO2	-0.956880272046224
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/1162	173/9376	0.792892461671625	ACTB/ACTG1/IFNGR2/AKT1/CCL2/RAB11B/TNFRSF10B/IL33/BAK1/STAT2/CDK6/KPNA2/SLC25A5/IL6/IFNAR2/PIK3R2/CYCS	-1.03410729116038
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1162	39/9376	0.620680524294982	CD40/HLA-B/HLA-F	-0.89278136913715
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1162	28/9376	0.576346201131055	ATP6V0D1/ATP6V1E2	-0.844388134366751
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1162	70/9376	0.691615441357266	HSD11B1/CBR1/PTGS2/GSTM4/GSTK1/GSTO2	-0.974028070335146
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/1162	109/9376	0.740261175764658	FOS/CD40/IRAK1/AKT1/JUN/STAT2/IL6/SPP1/IFNAR2/PIK3R2	-1.02586896296044
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/1162	110/9376	0.733531528712252	ANAPC11/ADCY5/PRKACA/ADCY6/GNAI2/AKT1/IGF1/MAD1L1/CPEB4/PIK3R2	-1.05732226594788
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1162	17/9376	0.47463804799028	CPS1	-0.815416897605775
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	16/1162	168/9376	0.768461601508073	CAPN2/CAMK2G/CAPN1/IFNGR2/PYGB/CHMP1A/TNFRSF10B/IL33/STAT3/PARP1/STAT2/SMPD1/PYGM/SLC25A5/STAT6/IFNAR2	-1.13895447041912
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1162	30/9376	0.537923121055651	PLA2G5/PLA2G2A	-0.953396010197736
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/1162	63/9376	0.640384667923394	PLOD1/DLST/SMYD3/ALDH2/ALDH1B1	-1.07714712265784
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1162	18/9376	0.448269267546376	FUCA1	-0.881217799459258
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1162	18/9376	0.448269267546376	HCFC1	-0.881217799459258
NA	NA	hsa04082	Neuroactive ligand signaling	19/1162	199/9376	0.770392409552063	P2RX1/SLC1A1/ADCY5/GNG5/PRKACA/GRIK4/ADRA2A/GABBR1/ADCY6/GNAI2/PRKCG/GNB4/SLC17A9/SLC18A3/HRH2/SLC6A1/CHAT/SLC1A2/GNB5	-1.23132803130941
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1162	54/9376	0.597692356728501	CD40/CGA/HLA-B/HLA-F	-1.11509525349952
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	17/1162	181/9376	0.757847490990006	TGFB3/CALM1/CAMK2G/MRC2/IRAK1/IFNGR2/TGFB2/RAB5C/AKT1/VDR/KSR1/ATP6V0D1/PLK3/SRC/IL6/CYCS/RIPK2	-1.23726790354755
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/1162	105/9376	0.691615441357266	PLAU/CD40/ERC1/IRAK1/PPP1R13L/PTGS2/LYN/PARP1/CXCL2	-1.19518555603257
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/1162	32/9376	0.504302925989673	LDHA/ACACA	-1.05641919240166
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1162	66/9376	0.611276273926876	HSD11B1/HSD3B2/HSD17B12/HSD11B2/RDH5	-1.19192664736948
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/1162	33/9376	0.489021019141501	STX18/GOSR2	-1.1059313882439
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/1162	45/9376	0.537923121055651	HLA-B/HLA-F/IL6	-1.16860503538469
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/1162	67/9376	0.602152747450356	CACNA1C/CALM1/CAMK2G/PRKACA/PRKCG	-1.22917467112401
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/1162	100/9376	0.645507745266781	CCL2/IL24/TNFRSF10B/TNFRSF10D/CXCL2/IL6/CCL26/IL19	-1.34041023013045
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1162	36/9376	0.448269267546376	CRPPA/AKR1A1	-1.24743044956503
NA	NA	hsa04081	Hormone signaling	20/1162	219/9376	0.736880987747467	SLCO1C1/CGA/PTH1R/GIP/ADCY5/GNG5/PRKACA/ADRA2A/ADCY6/GNAI2/ITGAV/IGF1/GNB4/SLC16A2/ITGB3/STAT3/SRC/GNA12/GNB5/PIK3R2	-1.48186634038422
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/1162	133/9376	0.66734823288859	MICB/IFNGR2/HLA-B/PRKCG/TNFRSF10B/VAV2/SHC1/NFATC2/NFATC1/IFNAR2/PIK3R2	-1.45318374662509
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1162	73/9376	0.5526607408106	FMO1/GSTM4/GSTK1/ALDH3B1/GSTO2	-1.44310618075402
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1162	38/9376	0.42467614820183	CD40/CD4	-1.3365604193885
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1162	51/9376	0.47463804799028	PLA2G5/PLA2G2A/PLD3	-1.41491593499488
NA	NA	hsa04382	Cornified envelope formation	19/1162	217/9376	0.706488891709035	S100A11/COL4A1/COL4A2/LAMB3/DSP/CLDN1/SLC27A4/CAPN1/PPP2R5B/PKP1/COL4A5/PCSK6/ELOVL1/S100A4/S100A16/PPP2CA/PPP2R2D/DST/CLDN16	-1.64528725187743
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1162	68/9376	0.47463804799028	RDH11/PNPLA4/DHRS4L2/RDH5	-1.63529548976272
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/1162	69/9376	0.467759235700566	AKT1/LYN/VAV2/PIK3R2	-1.66893405051561
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1162	44/9376	0.366765764356126	HLA-B/HLA-F	-1.58348776827691
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	20/1162	238/9376	0.678054354271829	RPS26/FOS/NRP1/IRAK1/RPL31/PRKCG/ADAM17/CCL2/JUN/RPL27A/RPL27/STAT3/STAT2/IL6/RPLP2/EGFR/ISG15/IFNAR2/PIK3R2/C9	-1.89215543842014
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1162	46/9376	0.350819426775425	ALAS1/HMOX2	-1.66002627444953
NA	NA	hsa04981	Folate transport and metabolism	1/1162	31/9376	0.26028538115596	ABCC3	-1.55155347628835
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/1162	191/9376	0.633679069306395	FOSB/CREB3L2/CALM1/ADCY5/GNG5/PRKACA/GNAI2/GNB4/CAMKK2/SHC1/HDAC7/HDAC8/HDAC3/GNB5/CREB3	-1.92375689841744
Human Diseases	Immune disease	hsa05310	Asthma	1/1162	32/9376	0.252151462994836	CD40	-1.59379909409209
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1162	50/9376	0.322753872633391	CD40/IL6	-1.80590616212671
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/1162	195/9376	0.579301822675317	ACTB/ACTG1/GSDMD/PRKCG/AKT1/ITGB3/MTOR/HDAC7/SRC/SLC25A5/HDAC8/HDAC3/AGER/PIK3R2	-2.23282299116988
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/1162	72/9376	0.336201950659782	ZNFX1/OTUD5/ISG15	-2.12656529569077
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1162	86/9376	0.375295200736501	CACNA1C/PRKACA/GABBR1/ADCY6	-2.18890827963914
Genetic Information Processing	Translation	hsa03010	Ribosome	16/1162	222/9376	0.581538509249353	RPS26/MRPL41/RPL31/MRPL52/MRPL23/MRPS11/MRPL33/RPL27A/RPL27/MRPL36/MRPS12/MRPL12/RPLP2/MRPL34/MRPL16/MRPL3	-2.37321936820396
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/1162	99/9376	0.244510509570751	CFI/CFH/DEFB1	-2.84219322084118
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1162	143/9376	0.225702008834539	ACTN1/ACTN4/CD40/C9	-3.50926436583776
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	21/1162	370/9376	0.457961576033865	P2RX1/PTGFR/NPFFR2/CGA/PTH1R/GIP/S1PR3/F2R/S1PR5/GRIK4/ADRA2A/GABBR1/PTGIR/LYPD6/SCT/EDNRA/F2RL1/HRH2/APLNR/LYPD6B/APLN	-4.0010715475277
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/1162	183/9376	0.220460295514611	GNL2/REXO5/LSG1/GNL3/MPHOSPH10	-4.00540566653436
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/1162	243/9376	0.199230785576167	DDX46/LSM7/NCBP2/HSPA8/PPIL1/EFTUD2	-4.75680260046212
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1162	449/9376	0.125794939222368	CALM1/SLC8A1/SLC24A4/NCALD/CAMK2G/PRKACA/OR51E1	-7.13994838702547