category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 20/163 203/9376 5.66714013720572 IGF1/COL4A1/CCND1/COL4A2/FN1/VCL/VAV2/MYLK/FLNB/ITGB1/ACTN4/DOCK1/LAMC1/ITGA3/PAK2/ACTB/BCAR1/PIP5K1C/PXN/FLNA 8.94174063207197 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 18/163 232/9376 4.4628728580495 FN1/FGFR1/VCL/VAV2/MYLK/ITGB1/ACTN4/DOCK1/ITGA3/MYH9/PAK2/ACTB/EZR/BCAR1/SSH2/PIP4K2A/PIP5K1C/PXN 7.10380996361758 NA NA hsa04518 Integrin signaling 14/163 154/9376 5.22922476296709 IGF1/COL4A1/CCND1/COL4A2/FN1/VCL/FLNB/ITGB1/ACTN4/LAMC1/ITGA3/ACTB/PXN/FLNA 7.03861924658475 NA NA hsa04517 IgSF CAM signaling 19/163 299/9376 3.65521062026797 PTPRD/NRP1/FGFR1/VCL/SPTBN1/VAV2/MYLK/ITGB1/ACTN4/CLEC4M/MYH9/PAK2/ACTB/SORBS1/EZR/BCAR1/JAM3/PXN/RASA1 6.20643637713239 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 16/163 233/9376 3.94997235314253 COL4A1/COL4A2/COL3A1/FN1/VCL/FHL2/JUP/SPTBN1/ITGB1/NID1/ITGA3/TPM4/MYH9/ACTB/FMNL2/FMNL3 6.0649950574186 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 9/163 78/9376 6.63709296838131 FN1/VCL/ARHGEF26/ITGB1/DOCK1/ACTB/BCAR1/ELMO1/PXN 6.64946390068251 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 10/163 103/9376 5.58460897015903 COL4A1/COL4A2/COL3A1/FN1/VCL/GNA14/IL1R1/ACTN4/LAMC1/TLR4 6.22285507970581 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 14/163 204/9376 3.94755202694575 IGF1/CCND1/FN1/FGFR1/VAV2/CD44/ITGB1/TLR4/ACTB/EZR/ITPR1/TP53/PXN/FLNA 5.66139484379172 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 11/163 138/9376 4.58504490086245 FN1/VAV2/ITGB1/DOCK1/TLR4/ACTB/BCAR1/ELMO1/PIP5K1C/PXN/NFATC2 5.64318214761196 Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 10/163 116/9376 4.958747620055 PECAM1/VCL/VAV2/ITGB1/ACTN4/ACTB/EZR/BCAR1/JAM3/PXN 5.70637385735325 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 9/163 93/9376 5.56659410251336 COL4A1/CCND1/COL4A2/FN1/CDK6/ITGB1/LAMC1/ITGA3/TP53 5.88665542736082 Organismal Systems Digestive system hsa04974 Protein digestion and absorption 9/163 103/9376 5.02614807314313 COL4A1/COL15A1/COL4A2/COL3A1/COL18A1/KCNQ1/PRCP/DPP4/SLC1A1 5.46483596565867 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 13/163 253/9376 2.95564877906836 VCL/CD44/ITGB1/IL1R1/ACTN4/DOCK1/TLR4/ACTB/BCAR1/ELMO1/ITPR1/TP53/PXN 4.19431640589246 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 7/163 89/9376 4.52416074998277 COL4A1/COL4A2/FN1/CD44/ITGB1/LAMC1/ITGA3 4.44315941369539 Organismal Systems Immune system hsa04666 Fc gamma R-mediated phagocytosis 7/163 98/9376 4.10867659947414 VAV2/DOCK1/BIN1/ASAP1/MARCKS/PIP5K1C/MYO10 4.11472014314149 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 7/163 115/9376 3.50130701520406 PDE4D/KL/FGFR1/CREB3L2/LRP5/ITPR1/ARRB1 3.58976388522528 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 14/163 362/9376 2.22458733010202 IGF1/COL4A1/CCND1/COL4A2/FN1/CDK6/FGFR1/ITGB1/CREB3L2/LAMC1/ITGA3/TLR4/IL4R/TP53 3.1605609871185 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 6/163 93/9376 3.71106273500891 FGFR1/VCL/ACTN4/ACTB/SORBS1/SMURF2 3.49474724591184 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 10/163 235/9376 2.44772222947396 MT-ND3/FGFR1/CREB3L2/MGLL/MT-ATP8/ATP5F1E/MT-ND5/ACTB/CPT1A/MT-CYB 2.98951835637107 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 9/163 200/9376 2.58846625766871 ITGB1/IL1R1/MYO1E/TLR4/MYH9/PAK2/ACTB/EZR/MYO10 3.0202660031108 Human Diseases Cancer: specific types hsa05218 Melanoma 5/163 73/9376 3.93982687620808 IGF1/CCND1/CDK6/FGFR1/TP53 3.35390363603522 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 8/163 170/9376 2.70689281847708 CCND1/CGNL1/ITGB1/ACTN4/MYH9/ACTB/EZR/JAM3 2.98726761971271 Organismal Systems Digestive system hsa04971 Gastric acid secretion 5/163 76/9376 3.7843073942525 MYLK/KCNQ1/ACTB/EZR/ITPR1 3.24161480684446 NA NA hsa04519 Cadherin signaling 14/163 404/9376 1.99331835023993 FGFR1/VCL/JUP/VAV2/LRP5/ACTN4/MYO1E/ANKRD6/TEAD1/GJA1/PCDH12/ACTB/WWTR1/FAT1 2.71464730946041 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 9/163 212/9376 2.44194929968746 IGF1/RAPGEF5/FGFR1/DOCK4/VAV2/P2RY1/ITGB1/ACTB/BCAR1 2.82458263919154 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 12/163 333/9376 2.07284585198696 COL4A1/CCND1/COL4A2/FN1/CDK6/ITGB1/CREB3L2/LAMC1/ITGA3/UBR4/TP53/PXN 2.65144170169982 Environmental Information Processing Signal transduction hsa04392 Hippo signaling pathway - multiple species 3/163 29/9376 5.950497144066 TEAD1/WWTR1/RASSF2 3.55132645627406 Environmental Information Processing Signal transduction hsa04340 Hedgehog signaling pathway 4/163 56/9376 4.10867659947414 CCND1/GLI3/ARRB1/SMURF2 3.10341965401943 Human Diseases Cardiovascular disease hsa05412 Arrhythmogenic right ventricular cardiomyopathy 5/163 86/9376 3.34427165073477 JUP/ITGB1/ITGA3/GJA1/ACTB 2.90488008447789 Human Diseases Infectious disease: viral hsa05163 Human cytomegalovirus infection 9/163 227/9376 2.28058701116186 CCND1/CDK6/CREB3L2/IL1R1/BCAR1/ITPR1/TP53/PXN/NFATC2 2.59785024441583 Cellular Processes Transport and catabolism hsa04148 Efferocytosis 7/163 157/9376 2.56465163534055 PECAM1/STAB1/DOCK1/BCAR1/ELMO1/CPT1A/NFATC2 2.62968955823928 Cellular Processes Cell motility hsa04814 Motor proteins 8/163 194/9376 2.37201948010879 DNAH8/KIF13A/MYO1E/TPM4/MYH9/ACTB/MYO15B/MYO10 2.56845169981943 Organismal Systems Immune system hsa04611 Platelet activation 6/163 126/9376 2.73911773298276 COL3A1/MYLK/P2RY1/ITGB1/ACTB/ITPR1 2.61410058581091 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 9/163 238/9376 2.17518172913337 MMP1/RPS26/NRP1/RPL36A/TLR4/RPL31/RPL27A/RPS17/RPS20 2.44256897921789 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 6/163 130/9376 2.65483718735252 COL4A1/COL4A2/MMP1/COL3A1/CREB3L2/ARRB1 2.52713770903785 Metabolism Glycan biosynthesis and metabolism hsa00604 Glycosphingolipid biosynthesis - ganglio series 2/163 15/9376 7.66952965235174 ST3GAL5/ST3GAL1 3.43841758670332 Environmental Information Processing Signal transduction hsa04070 Phosphatidylinositol signaling system 5/163 98/9376 2.93476899962439 DGKH/ITPKB/ITPR1/PIP4K2A/PIP5K1C 2.56090742164265 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 5/163 99/9376 2.90512486831505 IGF1/ITGB1/ITGA3/TPM4/ACTB 2.53463933208986 Organismal Systems Immune system hsa04640 Hematopoietic cell lineage 5/163 100/9376 2.8760736196319 CD44/IL1R1/ITGA3/IL4R/CD34 2.50869816131699 Cellular Processes Transport and catabolism hsa04144 Endocytosis 9/163 250/9376 2.07077300613497 AGAP1/CBLB/BIN1/ASAP1/PIP5K1C/PSD3/ARRB1/MVB12B/SMURF2 2.28247532460026 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 5/163 101/9376 2.8475976431999 COL4A1/CCND1/COL4A2/COL3A1/FN1 2.48307611355298 Human Diseases Infectious disease: viral hsa05162 Measles 6/163 136/9376 2.53771201732227 CCND1/CDK6/CBLB/TLR4/CLEC4M/TP53 2.40263269035881 Human Diseases Cancer: specific types hsa05219 Bladder cancer 3/163 41/9376 4.20888822385156 CCND1/MMP1/TP53 2.73885008710545 NA NA hsa03273 Virion - Lassa virus and SFTS virus 2/163 17/9376 6.76723204619271 CLEC4M/MYH9 3.16560022111955 Organismal Systems Immune system hsa04625 C-type lectin receptor signaling pathway 5/163 105/9376 2.73911773298276 KSR1/CBLB/CLEC4M/ITPR1/NFATC2 2.38363221999686 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 5/163 105/9376 2.73911773298276 IGF1/ITGB1/ITGA3/TPM4/ACTB 2.38363221999686 Human Diseases Cancer: specific types hsa05215 Prostate cancer 5/163 106/9376 2.71327699965274 IGF1/CCND1/FGFR1/CREB3L2/TP53 2.35949768188277 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 4/163 75/9376 3.0678118609407 IGF1/CCND1/CDK6/TP53 2.39141933594638 Organismal Systems Development and regeneration hsa04360 Axon guidance 7/163 184/9376 2.18831688450253 ABLIM3/NRP1/ITGB1/PAK2/SSH2/RASA1/NFATC2 2.1652850453927 Organismal Systems Endocrine system hsa03320 PPAR signaling pathway 4/163 76/9376 3.027445915402 MMP1/FADS2/SORBS1/CPT1A 2.36044292846763 Human Diseases Cancer: specific types hsa05214 Glioma 4/163 76/9376 3.027445915402 IGF1/CCND1/CDK6/TP53 2.36044292846763 Human Diseases Cancer: specific types hsa05224 Breast cancer 6/163 148/9376 2.33195158348533 IGF1/CCND1/CDK6/FGFR1/LRP5/TP53 2.17242307980389 Organismal Systems Endocrine system hsa04913 Ovarian steroidogenesis 3/163 52/9376 3.31854648419066 IGF1/BMP6/SCARB1 2.22995064821414 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 7/163 205/9376 1.9641478377974 CCND1/CDK6/CREB3L2/ACTN4/UBR4/TP53/PXN 1.8564836136827 Organismal Systems Aging hsa04211 Longevity regulating pathway 4/163 90/9376 2.55650988411725 IGF1/KL/CREB3L2/TP53 1.97350259934178 Organismal Systems Digestive system hsa04977 Vitamin digestion and absorption 2/163 26/9376 4.42472864558754 ABCC1/SCARB1 2.32587269231859 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 9/163 300/9376 1.72564417177914 IGF1/CDC25B/FGFR1/IL1R1/PAK2/TP53/ARRB1/FLNA/RASA1 1.69908849834575 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 6/163 174/9376 1.983499048022 RRBP1/SEC62/SEC31A/GANAB/TXNDC5/PRKCSH 1.74175216236139 Organismal Systems Circulatory system hsa04270 Vascular smooth muscle contraction 5/163 134/9376 2.14632359674022 RAMP3/MYLK/CALD1/MYH9/ITPR1 1.77768805504097 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 9/163 308/9376 1.68082224523942 DNAH8/MT-ND3/CREB3L2/MT-ATP8/ATP5F1E/MT-ND5/ITPR1/TP53/MT-CYB 1.61596609624199 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 6/163 178/9376 1.9389260357069 CCND1/RSPO3/LRP5/ANKRD6/TP53/NFATC2 1.68218433833094 Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 5/163 138/9376 2.08411131857384 MT-ND3/MT-ATP8/ATP5F1E/MT-ND5/MT-CYB 1.70648842850705 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 5/163 140/9376 2.05433829973707 CCND1/APLNR/APLN/MYLK/ITPR1 1.67178699873841 Organismal Systems Endocrine system hsa04927 Cortisol synthesis and secretion 3/163 65/9376 2.65483718735252 CREB3L2/SCARB1/ITPR1 1.78070792522665 Human Diseases Neurodegenerative disease hsa05020 Prion disease 8/163 275/9376 1.67335192414947 MT-ND3/CREB3L2/LAMC1/MT-ATP8/ATP5F1E/MT-ND5/ITPR1/MT-CYB 1.5074495970984 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 9/163 323/9376 1.60276548462459 CCND1/FSCN1/CDC25B/CDK6/CD44/ABCC1/MARCKS/EZR/TP53 1.46633189655393 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 7/163 238/9376 1.69180801154818 IGF1/RAPGEF5/FGFR1/RALGAPA2/KSR1/PAK2/RASA1 1.43789572854244 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 5/163 154/9376 1.86758027248825 CCND1/MYLK/ACTB/ITPR1/NFATC2 1.44389753350655 Cellular Processes Transport and catabolism hsa04145 Phagosome 5/163 155/9376 1.85553136750445 ITGB1/SCARB1/TLR4/CLEC4M/ACTB 1.42853761453628 Human Diseases Endocrine and metabolic disease hsa04934 Cushing syndrome 5/163 155/9376 1.85553136750445 CCND1/CDK6/CREB3L2/SCARB1/ITPR1 1.42853761453628 Human Diseases Cancer: specific types hsa05223 Non-small cell lung cancer 3/163 73/9376 2.36389612572485 CCND1/CDK6/TP53 1.55600188986066 Human Diseases Infectious disease: parasitic hsa05143 African trypanosomiasis 2/163 37/9376 3.10926877798043 IDO2/APOL1 1.70986374275564 Human Diseases Cancer: specific types hsa05216 Thyroid cancer 2/163 37/9376 3.10926877798043 CCND1/TP53 1.70986374275564 Cellular Processes Cell growth and death hsa04218 Cellular senescence 5/163 157/9376 1.83189402524325 CCND1/CDK6/ITPR1/TP53/NFATC2 1.39815341788057 Environmental Information Processing Signal transduction hsa04390 Hippo signaling pathway 5/163 157/9376 1.83189402524325 CCND1/BMP6/TEAD1/ACTB/WWTR1 1.39815341788057 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 7/163 248/9376 1.6235899465664 ARHGEF26/SNX9/TLR4/ACTB/ELMO1/AHNAK/FLNA 1.32378066781928 Organismal Systems Nervous system hsa04724 Glutamatergic synapse 4/163 116/9376 1.983499048022 GRM7/SHANK3/ITPR1/SLC1A1 1.41767391988646 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 5/163 160/9376 1.79754601226994 PTPRD/PECAM1/ITGB1/CD34/JAM3 1.35339139544868 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 6/163 205/9376 1.68355528954063 MT-ND3/COL3A1/MT-ATP8/ATP5F1E/MT-ND5/MT-CYB 1.31619772853234 Human Diseases Cancer: specific types hsa05212 Pancreatic cancer 3/163 77/9376 2.2410963269859 CCND1/CDK6/TP53 1.45449299466344 Human Diseases Cancer: specific types hsa05220 Chronic myeloid leukemia 3/163 77/9376 2.2410963269859 CCND1/CDK6/TP53 1.45449299466344 Metabolism Carbohydrate metabolism hsa00562 Inositol phosphate metabolism 3/163 78/9376 2.21236432279377 ITPKB/PIP4K2A/PIP5K1C 1.43009399421125 Environmental Information Processing Signal transduction hsa04022 cGMP-PKG signaling pathway 5/163 166/9376 1.73257446965777 MYLK/CREB3L2/GTF2I/ITPR1/NFATC2 1.26664499996249 Environmental Information Processing Signal transduction hsa04152 AMPK signaling pathway 4/163 122/9376 1.88594991451272 IGF1/CCND1/CREB3L2/CPT1A 1.31009636952615 Organismal Systems Immune system hsa04660 T cell receptor signaling pathway 4/163 122/9376 1.88594991451272 VAV2/CBLB/PAK2/NFATC2 1.31009636952615 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 4/163 122/9376 1.88594991451272 IGF1/CREB3L2/BCAR1/ITPR1 1.31009636952615 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 6/163 216/9376 1.59781867757328 MMP1/VAV2/TLR4/ITPR1/TP53/NFATC2 1.18229954672812 Human Diseases Cancer: specific types hsa05225 Hepatocellular carcinoma 5/163 170/9376 1.69180801154818 CCND1/CDK6/LRP5/ACTB/TP53 1.21074718317672 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 7/163 268/9376 1.50242651771816 MT-ND3/MT-ATP8/ATP5F1E/MT-ND5/ITPR1/TP53/MT-CYB 1.1099600401297 Environmental Information Processing Signal transduction hsa04012 ErbB signaling pathway 3/163 86/9376 2.00656299044086 NRG3/CBLB/PAK2 1.24727216821809 Genetic Information Processing Translation hsa03010 Ribosome 6/163 222/9376 1.55463438899022 RPS26/RPL36A/RPL31/RPL27A/RPS17/RPS20 1.1123891178125 Genetic Information Processing Information processing in viruses hsa03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus 1/163 12/9376 4.79345603271984 CLEC4M 1.74893585028236 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 9/163 368/9376 1.40677514003734 DNAH8/MT-ND3/MT-ATP8/NRG3/ATP5F1E/MT-ND5/ACTB/TP53/MT-CYB 1.05887093784454 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 6/163 224/9376 1.5407537248028 CCND1/NRP1/CREB3L2/IL1R1/TP53/NFATC2 1.08954313309841 NA NA hsa03272 Virion - Hepatitis viruses 2/163 48/9376 2.39672801635992 SCARB1/DPP4 1.2903784436533 Human Diseases Infectious disease: parasitic hsa05144 Malaria 2/163 50/9376 2.30085889570552 PECAM1/TLR4 1.22672267398577 Metabolism Glycan biosynthesis and metabolism hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 1/163 14/9376 4.10867659947414 ST3GAL1 1.54822525795716 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 2/163 51/9376 2.25574401539757 KCNQ1/ACTB 1.19602618996363 Organismal Systems Immune system hsa04621 NOD-like receptor signaling pathway 5/163 187/9376 1.53800728322562 CARD16/CARD18/ANTXR2/TLR4/ITPR1 0.988447795726694 Organismal Systems Digestive system hsa04979 Cholesterol metabolism 2/163 52/9376 2.21236432279377 CETP/SCARB1 1.16603769901529 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 4/163 142/9376 1.6203231659898 FHL2/IL1R1/ITPR1/NFATC2 0.990709077099443 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 4/163 142/9376 1.6203231659898 PECAM1/IL1R1/ACTB/TP53 0.990709077099443 Organismal Systems Endocrine system hsa04925 Aldosterone synthesis and secretion 3/163 98/9376 1.76086139977463 CREB3L2/SCARB1/ITPR1 1.00709470014382 Metabolism Glycan biosynthesis and metabolism hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/163 16/9376 3.59509202453988 ST3GAL1 1.38182719246 Organismal Systems Immune system hsa04062 Chemokine signaling pathway 5/163 193/9376 1.4901935853015 VAV2/BCAR1/ELMO1/PXN/ARRB1 0.915235571235653 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 3/163 99/9376 1.74307492098903 IGF1/CCND1/TP53 0.988610748173225 Organismal Systems Sensory system hsa04750 Inflammatory mediator regulation of TRP channels 3/163 99/9376 1.74307492098903 IGF1/IL1R1/ITPR1 0.988610748173225 Human Diseases Cancer: overview hsa05231 Choline metabolism in cancer 3/163 99/9376 1.74307492098903 SLC44A4/DGKH/PIP5K1C 0.988610748173225 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 5/163 196/9376 1.46738449981219 CCND1/CDK6/ITPR1/TP53/NFATC2 0.879548729060517 Metabolism Energy metabolism hsa00910 Nitrogen metabolism 1/163 17/9376 3.38361602309636 CA8 1.30835301048086 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 4/163 149/9376 1.54420060114465 MT-ND3/MGLL/MT-ND5/ITPR1 0.89063712859814 Metabolism Global and overview maps hsa01212 Fatty acid metabolism 2/163 57/9376 2.01829727693467 FADS2/CPT1A 1.0256667083949 Human Diseases Cancer: specific types hsa05226 Gastric cancer 4/163 150/9376 1.53390593047035 CCND1/JUP/LRP5/TP53 0.87676368662275 Human Diseases Cancer: specific types hsa05213 Endometrial cancer 2/163 59/9376 1.94988042008943 CCND1/TP53 0.973499647364658 Environmental Information Processing Signal transduction hsa04370 VEGF signaling pathway 2/163 60/9376 1.91738241308793 PXN/NFATC2 0.948178711254969 Organismal Systems Nervous system hsa04730 Long-term depression 2/163 60/9376 1.91738241308793 IGF1/ITPR1 0.948178711254969 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 6/163 254/9376 1.35877493840877 FGFR1/GNA14/MYLK/ITPKB/ITPR1/NFATC2 0.771032754290294 Organismal Systems Endocrine system hsa04922 Glucagon signaling pathway 3/163 107/9376 1.61275156241041 CREB3L2/ITPR1/CPT1A 0.847888568256552 Human Diseases Infectious disease: viral hsa05160 Hepatitis C 4/163 156/9376 1.47490954852918 CCND1/CDK6/SCARB1/TP53 0.795585107613601 Environmental Information Processing Signal transduction hsa04330 Notch signaling pathway 2/163 62/9376 1.85553136750445 NUMB/ATXN1 0.898964558437986 Organismal Systems Immune system hsa04659 Th17 cell differentiation 3/163 109/9376 1.58315979062307 IL1R1/IL4R/NFATC2 0.814535737578572 Cellular Processes Cell growth and death hsa04110 Cell cycle 4/163 158/9376 1.45623980740856 CCND1/CDC25B/CDK6/TP53 0.76927615622166 Metabolism Lipid metabolism hsa00100 Steroid biosynthesis 1/163 20/9376 2.8760736196319 SQLE 1.11711703063961 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 3/163 110/9376 1.56876742889013 IGF1/EPAS1/TLR4 0.798111957457002 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 3/163 110/9376 1.56876742889013 BMP6/SMAD5/SMURF2 0.798111957457002 Human Diseases Cancer: specific types hsa05217 Basal cell carcinoma 2/163 63/9376 1.82607848865518 GLI3/TP53 0.875035537479125 Metabolism Glycan biosynthesis and metabolism hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/163 21/9376 2.73911773298276 CHSY1 1.06119608642641 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 3/163 112/9376 1.5407537248028 ITGB1/LAMC1/TLR4 0.765752040207247 Metabolism Lipid metabolism hsa00561 Glycerolipid metabolism 2/163 65/9376 1.76989145823502 DGKH/MGLL 0.828451180406876 Organismal Systems Endocrine system hsa04929 GnRH secretion 2/163 65/9376 1.76989145823502 ITPR1/ARRB1 0.828451180406876 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 4/163 163/9376 1.41156987466596 CREB3L2/TLR4/TP53/NFATC2 0.70504323529865 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 5/163 214/9376 1.34395963534201 TLR4/PAK2/ITPR1/PXN/NFATC2 0.677014745227406 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 2/163 66/9376 1.74307492098903 TLR4/IL4R 0.805765439825122 Organismal Systems Nervous system hsa04725 Cholinergic synapse 3/163 115/9376 1.50056014937317 CREB3L2/KCNQ1/ITPR1 0.718381524411218 Human Diseases Cancer: specific types hsa05221 Acute myeloid leukemia 2/163 68/9376 1.69180801154818 CCND1/JUP 0.761536565423402 Organismal Systems Endocrine system hsa04614 Renin-angiotensin system 1/163 23/9376 2.50093358228861 PRCP 0.958581030423052 Metabolism Glycan biosynthesis and metabolism hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1/163 24/9376 2.39672801635992 HS3ST3A1 0.911263806108362 Human Diseases Cancer: specific types hsa05211 Renal cell carcinoma 2/163 70/9376 1.64347063978966 EPAS1/PAK2 0.718745496442931 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 2/163 70/9376 1.64347063978966 CCND1/ACTB 0.718745496442931 Human Diseases Cancer: overview hsa05230 Central carbon metabolism in cancer 2/163 71/9376 1.6203231659898 FGFR1/TP53 0.697859332415051 Human Diseases Infectious disease: viral hsa05164 Influenza A 4/163 173/9376 1.32997624029221 CDK6/IL33/TLR4/ACTB 0.582666320157384 Organismal Systems Endocrine system hsa04919 Thyroid hormone signaling pathway 3/163 122/9376 1.41446243588454 CCND1/ACTB/TP53 0.61288536029257 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 5/163 227/9376 1.26699278397881 MT-ND3/MT-ATP8/ATP5F1E/MT-ND5/MT-CYB 0.541632285093473 Metabolism Lipid metabolism hsa00592 alpha-Linolenic acid metabolism 1/163 26/9376 2.21236432279377 FADS2 0.823365984093491 Organismal Systems Endocrine system hsa04918 Thyroid hormone synthesis 2/163 75/9376 1.53390593047035 CREB3L2/ITPR1 0.617460896622572 Metabolism Lipid metabolism hsa01040 Biosynthesis of unsaturated fatty acids 1/163 27/9376 2.13042490343104 FADS2 0.782383933555816 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 2/163 78/9376 1.47490954852918 ITGB1/TLR4 0.560199009799372 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 2/163 78/9376 1.47490954852918 ITGB1/TLR4 0.560199009799372 Organismal Systems Nervous system hsa04728 Dopaminergic synapse 3/163 133/9376 1.29747682088657 CREB3L2/ITPR1/ARRB1 0.459569692556042 Human Diseases Drug resistance: antineoplastic hsa01523 Antifolate resistance 1/163 30/9376 1.91738241308793 ABCC1 0.669386661190053 Metabolism Carbohydrate metabolism hsa00053 Ascorbate and aldarate metabolism 1/163 31/9376 1.85553136750445 KL 0.634608721224769 Genetic Information Processing Folding, sorting and degradation hsa03060 Protein export 1/163 31/9376 1.85553136750445 SEC62 0.634608721224769 NA NA hsa04981 Folate transport and metabolism 1/163 31/9376 1.85553136750445 ABCC1 0.634608721224769 Cellular Processes Cell growth and death hsa04210 Apoptosis 3/163 137/9376 1.25959428597018 ACTB/ITPR1/TP53 0.407119433596044 Organismal Systems Endocrine system hsa04910 Insulin signaling pathway 3/163 138/9376 1.25046679114431 PRKAR2B/CBLB/SORBS1 0.394257188805409 Organismal Systems Circulatory system hsa04260 Cardiac muscle contraction 2/163 87/9376 1.32233269868133 TPM4/MT-CYB 0.401752339050215 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 2/163 87/9376 1.32233269868133 CCND1/TP53 0.401752339050215 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 9/163 480/9376 1.07852760736196 DNAH8/MT-ND3/LRP5/MT-ATP8/ATP5F1E/MT-ND5/ITPR1/ATXN1/MT-CYB 0.23492243928584 Cellular Processes Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells 3/163 144/9376 1.19836400817996 IGF1/FGFR1/SMAD5 0.319062032999391 Human Diseases Endocrine and metabolic disease hsa04936 Alcoholic liver disease 3/163 144/9376 1.19836400817996 CCND1/TLR4/CPT1A 0.319062032999391 Cellular Processes Cellular community - eukaryotes hsa04540 Gap junction 2/163 89/9376 1.29261735713793 GJA1/ITPR1 0.368923456452556 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 4/163 201/9376 1.14470591826145 IGF1/JUP/FLI1/TP53 0.275841871409579 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 2/163 90/9376 1.27825494205862 TLR4/NFATC2 0.352800105566837 Metabolism Carbohydrate metabolism hsa00040 Pentose and glucuronate interconversions 1/163 36/9376 1.59781867757328 KL 0.477998128922716 Metabolism Glycan biosynthesis and metabolism hsa00512 Mucin type O-glycan biosynthesis 1/163 36/9376 1.59781867757328 ST3GAL1 0.477998128922716 Organismal Systems Immune system hsa04662 B cell receptor signaling pathway 2/163 91/9376 1.26420818445358 VAV2/NFATC2 0.336864242347623 Human Diseases Substance dependence hsa05032 Morphine addiction 2/163 91/9376 1.26420818445358 PDE4D/ARRB1 0.336864242347623 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 4/163 205/9376 1.12237019302708 CCND1/CDK6/CD44/TP53 0.235625958231634 Environmental Information Processing Signal transduction hsa04072 Phospholipase D signaling pathway 3/163 149/9376 1.15815045085848 GRM7/DGKH/PIP5K1C 0.258828570094988 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 2/163 93/9376 1.23702091166964 IL4R/NFATC2 0.305536337313216 Metabolism Metabolism of cofactors and vitamins hsa00760 Nicotinate and nicotinamide metabolism 1/163 38/9376 1.513722957701 NT5E 0.422058588924319 Organismal Systems Excretory system hsa04960 Aldosterone-regulated sodium reabsorption 1/163 38/9376 1.513722957701 IGF1 0.422058588924319 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 2/163 95/9376 1.2109783661608 MMP1/TLR4 0.274904118246032 Organismal Systems Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes 3/163 154/9376 1.12054816349295 CREB3L2/KCNQ1/TPM4 0.200626041711398 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 7/163 388/9376 1.03775852254759 MT-ND3/LRP5/MT-ATP8/ATP5F1E/MT-ND5/ITPR1/MT-CYB 0.101036484823936 Environmental Information Processing Signal transduction hsa04150 mTOR signaling pathway 3/163 158/9376 1.09217985555642 IGF1/RNF152/LRP5 0.155426518712359 Metabolism Amino acid metabolism hsa00380 Tryptophan metabolism 1/163 42/9376 1.36955886649138 IDO2 0.319266446222112 Cellular Processes Cell growth and death hsa04216 Ferroptosis 1/163 42/9376 1.36955886649138 TP53 0.319266446222112 NA NA hsa04382 Cornified envelope formation 4/163 217/9376 1.06030363857397 COL4A1/COL4A2/JUP/UGCG 0.11954413102079 Metabolism Lipid metabolism hsa00071 Fatty acid degradation 1/163 43/9376 1.33770866029391 CPT1A 0.295219267034325 Organismal Systems Digestive system hsa04975 Fat digestion and absorption 1/163 43/9376 1.33770866029391 SCARB1 0.295219267034325 NA NA hsa04081 Hormone signaling 4/163 219/9376 1.05062050032216 RAMP3/IGF1/GNA14/SMAD5 0.100820950728939 Organismal Systems Digestive system hsa04972 Pancreatic secretion 2/163 102/9376 1.12787200769878 KCNQ1/ITPR1 0.172711369919015 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 2/163 103/9376 1.11692179403181 GNA14/TLR4 0.158702167328767 Genetic Information Processing Transcription hsa03022 Basal transcription factors 1/163 44/9376 1.30730619074177 GTF2I 0.27176228614558 Organismal Systems Excretory system hsa04962 Vasopressin-regulated water reabsorption 1/163 44/9376 1.30730619074177 CREB3L2 0.27176228614558 Environmental Information Processing Membrane transport hsa02010 ABC transporters 1/163 45/9376 1.27825494205862 ABCC1 0.248865075154215 Environmental Information Processing Signal transduction hsa04064 NF-kappa B signaling pathway 2/163 105/9376 1.09564709319311 IL1R1/TLR4 0.13109376597127 Cellular Processes Transport and catabolism hsa04137 Mitophagy - animal 2/163 105/9376 1.09564709319311 TP53/SMURF2 0.13109376597127 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 4/163 226/9376 1.01807915739182 PDE4D/VAV2/CREB3L2/GLI3 0.0365932314854248 Human Diseases Endocrine and metabolic disease hsa04931 Insulin resistance 2/163 109/9376 1.05543986041538 CREB3L2/CPT1A 0.0774363190343493 Organismal Systems Endocrine system hsa04914 Progesterone-mediated oocyte maturation 2/163 110/9376 1.04584495259342 IGF1/CDC25B 0.0643310481496035 Human Diseases Substance dependence hsa05030 Cocaine addiction 1/163 49/9376 1.17390759984976 CREB3L2 0.162339617275162 Metabolism Amino acid metabolism hsa00330 Arginine and proline metabolism 1/163 50/9376 1.15042944785276 P4HA3 0.141856442020992 Organismal Systems Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption 1/163 53/9376 1.08531079986109 KL 0.0828405571987196 Metabolism Amino acid metabolism hsa00270 Cysteine and methionine metabolism 1/163 54/9376 1.06521245171552 MRI1 0.0639222073591345 Human Diseases Infectious disease: bacterial hsa05152 Tuberculosis 3/163 181/9376 0.953394570043724 KSR1/TLR4/CLEC4M -0.084212942883575 Metabolism Lipid metabolism hsa00600 Sphingolipid metabolism 1/163 55/9376 1.04584495259342 UGCG 0.0453545146236424 Metabolism Glycan biosynthesis and metabolism hsa00510 N-Glycan biosynthesis 1/163 56/9376 1.02716914986854 GANAB 0.0271232053212863 Human Diseases Infectious disease: bacterial hsa05134 Legionellosis 1/163 56/9376 1.02716914986854 TLR4 0.0271232053212863 Environmental Information Processing Signal transduction hsa04071 Sphingolipid signaling pathway 2/163 125/9376 0.920343558282208 ABCC1/TP53 -0.119250572658112 Metabolism Nucleotide metabolism hsa00240 Pyrimidine metabolism 1/163 59/9376 0.974940210044713 NT5E -0.0256829135210599 Organismal Systems Endocrine system hsa04923 Regulation of lipolysis in adipocytes 1/163 59/9376 0.974940210044713 MGLL -0.0256829135210599 Metabolism Nucleotide metabolism hsa00230 Purine metabolism 2/163 128/9376 0.898773006134969 PDE4D/NT5E -0.153375615621305 Organismal Systems Aging hsa04213 Longevity regulating pathway - multiple species 1/163 62/9376 0.927765683752226 IGF1 -0.0759014720864826 Metabolism Amino acid metabolism hsa00310 Lysine degradation 1/163 63/9376 0.913039244327588 PLOD2 -0.0921144329799433 Environmental Information Processing Signal transduction hsa04068 FoxO signaling pathway 2/163 133/9376 0.864984547257715 IGF1/CCND1 -0.208584352630103 Organismal Systems Immune system hsa04650 Natural killer cell mediated cytotoxicity 2/163 133/9376 0.864984547257715 VAV2/NFATC2 -0.208584352630103 NA NA hsa04082 Neuroactive ligand signaling 3/163 199/9376 0.8671578752659 GRM7/P2RY1/SLC1A1 -0.251936383266907 Organismal Systems Nervous system hsa04720 Long-term potentiation 1/163 67/9376 0.85852943869609 ITPR1 -0.154572014733767 Cellular Processes Cell growth and death hsa04114 Oocyte meiosis 2/163 138/9376 0.833644527429537 IGF1/ITPR1 -0.26185843104541 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 2/163 139/9376 0.827647084786159 CREB3L2/ITPR1 -0.272294874593267 Organismal Systems Immune system hsa04664 Fc epsilon RI signaling pathway 1/163 69/9376 0.833644527429537 VAV2 -0.184474221218621 Organismal Systems Endocrine system hsa04924 Renin secretion 1/163 69/9376 0.833644527429537 ITPR1 -0.184474221218621 Human Diseases Substance dependence hsa05031 Amphetamine addiction 1/163 69/9376 0.833644527429537 CREB3L2 -0.184474221218621 Organismal Systems Endocrine system hsa04920 Adipocytokine signaling pathway 1/163 70/9376 0.821735319894829 CPT1A -0.199118542599417 Genetic Information Processing Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis 2/163 142/9376 0.810161582994902 CBLB/SMURF2 -0.303188165815222 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 1/163 71/9376 0.810161582994902 CCND1 -0.213566924824609 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 1/163 71/9376 0.810161582994902 JAM3 -0.213566924824609 Human Diseases Neurodegenerative disease hsa05017 Spinocerebellar ataxia 2/163 144/9376 0.798909338786639 ITPR1/ATXN1 -0.323447765411753 Genetic Information Processing Information processing in viruses hsa03250 Viral life cycle - HIV-1 1/163 73/9376 0.787965375241617 BICD1 -0.241899856313909 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 3/163 217/9376 0.79522772893048 CCND1/CREB3L2/ARRB1 -0.405934430840871 Human Diseases Drug resistance: antineoplastic hsa01524 Platinum drug resistance 1/163 75/9376 0.766952965235174 TP53 -0.26951832303933 Organismal Systems Nervous system hsa04721 Synaptic vesicle cycle 1/163 79/9376 0.728119903704279 SLC1A1 -0.322773929962637 Human Diseases Drug resistance: antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance 1/163 80/9376 0.719018404907976 IGF1 -0.335701834393631 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 4/163 298/9376 0.772100300572323 BMP6/IL33/IL1R1/IL4R -0.531784531001342 Genetic Information Processing Chromosome hsa03083 Polycomb repressive complex 1/163 83/9376 0.693029787863109 AUTS2 -0.373625248383471 Organismal Systems Immune system hsa04623 Cytosolic DNA-sensing pathway 1/163 83/9376 0.693029787863109 IL33 -0.373625248383471 Metabolism Global and overview maps hsa01232 Nucleotide metabolism 1/163 85/9376 0.676723204619271 NT5E -0.398227887501865 Organismal Systems Sensory system hsa04742 Taste transduction 1/163 86/9376 0.668854330146954 P2RY1 -0.4103357480417 Organismal Systems Endocrine system hsa04911 Insulin secretion 1/163 86/9376 0.668854330146954 CREB3L2 -0.4103357480417 Cellular Processes Cell growth and death hsa04217 Necroptosis 2/163 168/9376 0.684779433245691 IL33/TLR4 -0.548359581004523 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 2/163 168/9376 0.684779433245691 CCND1/IL4R -0.548359581004523 Organismal Systems Digestive system hsa04976 Bile secretion 1/163 90/9376 0.639127471029312 SCARB1 -0.457551141320636 Cellular Processes Transport and catabolism hsa04140 Autophagy - animal 2/163 169/9376 0.680727483936545 UVRAG/ITPR1 -0.557089175921247 Organismal Systems Endocrine system hsa04912 GnRH signaling pathway 1/163 93/9376 0.618510455834818 ITPR1 -0.491766389836441 Organismal Systems Digestive system hsa04970 Salivary secretion 1/163 93/9376 0.618510455834818 ITPR1 -0.491766389836441 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 1/163 94/9376 0.61193055736849 MMP1 -0.502957740654068 Organismal Systems Environmental adaptation hsa04713 Circadian entrainment 1/163 97/9376 0.593004870027196 ITPR1 -0.535924235577674 Organismal Systems Endocrine system hsa04916 Melanogenesis 1/163 101/9376 0.569519528639981 CREB3L2 -0.578543591305848 Metabolism Lipid metabolism hsa00564 Glycerophospholipid metabolism 1/163 104/9376 0.553091080698443 DGKH -0.609576035788424 Organismal Systems Immune system hsa04620 Toll-like receptor signaling pathway 1/163 109/9376 0.527719930207688 TLR4 -0.659663099509873 Organismal Systems Immune system hsa04613 Neutrophil extracellular trap formation 2/163 195/9376 0.589963819411672 TLR4/ACTB -0.769614774360109 Organismal Systems Nervous system hsa04726 Serotonergic synapse 1/163 115/9376 0.500186716457722 ITPR1 -0.717309655995812 Genetic Information Processing Chromosome hsa03082 ATP-dependent chromatin remodeling 1/163 117/9376 0.491636516176394 ACTB -0.735976827970446 Environmental Information Processing Signal transduction hsa04668 TNF signaling pathway 1/163 119/9376 0.483373717585194 CREB3L2 -0.754386225606543 Organismal Systems Nervous system hsa04722 Neurotrophin signaling pathway 1/163 120/9376 0.479345603271984 TP53 -0.763497105725389 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 4/163 370/9376 0.621853755596087 APLNR/GRM7/APLN/P2RY1 -0.987128264026269 Human Diseases Immune disease hsa05322 Systemic lupus erythematosus 1/163 143/9376 0.402248058689776 ACTN4 -0.95806836682347 Metabolism Global and overview maps hsa01240 Biosynthesis of cofactors 1/163 154/9376 0.37351605449765 IDO2 -1.04264545008376 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 1/163 157/9376 0.36637880504865 MT-CYB -1.06491886283684 Human Diseases Infectious disease: viral hsa05168 Herpes simplex virus 1 infection 1/163 180/9376 0.319563735514656 TP53 -1.22603573247498 Human Diseases Substance dependence hsa05034 Alcoholism 1/163 191/9376 0.301159541322712 CREB3L2 -1.29787852995257 Genetic Information Processing Transcription hsa03040 Spliceosome 1/163 243/9376 0.236713878159004 HNRNPU -1.60347679320998 Cellular Processes Transport and catabolism hsa04142 Lysosome biogenesis 1/163 250/9376 0.230085889570552 GPR155 -1.64116012361939 Organismal Systems Sensory system hsa04740 Olfactory transduction 1/163 449/9376 0.128110183502535 ARRB1 -2.51831999176373