category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	42/373	238/9376	4.43589339220943	RPS26/RPL34/RPS18/NRP1/RPL26/RPL41/RPL27A/RPL21/RPS12/FAU/RPLP2/RPS14/EGFR/RPL37A/RPS16/RPL36A/RPL23/RPL37/RPL23A/RPS8/RPS27/RPS25/RPS15A/RPLP1/RPL31/RPS27A/RPS29/RPS21/RPS23/RPL32/RPL35A/RPS19/RPL27/PIK3R3/RPS15/RPL17/RPL30/UBA52/RPL35/PLCG2/RPL22/RPL12	10.928209470556
Genetic Information Processing	Translation	hsa03010	Ribosome	38/373	222/9376	4.30268338043137	RPS26/RPL34/RPS18/RPL26/RPL41/RPL27A/RPL21/RPS12/FAU/RPLP2/RPS14/RPL37A/RPS16/RPL36A/RPL23/RPL37/RPL23A/RPS8/RPS27/RPS25/RPS15A/RPLP1/RPL31/RPS27A/RPS29/RPS21/RPS23/RPL32/RPL35A/RPS19/RPL27/RPS15/RPL17/RPL30/UBA52/RPL35/RPL22/RPL12	10.136415474351
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	18/373	170/9376	2.66153603532566	LRP5/EGFR/MET/CDK6/GSTA3/CCND1/WNT6/IGF1R/GAB1/PIK3R3/CTNNB1/GSTM4/TCF7/DVL3/SMARCA2/PLCG2/ARID2/SHC4	4.4498479254159
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	26/373	333/9376	1.96262750686343	LAMB4/EGFR/JAG1/HES1/NOTCH3/CDK6/CCND1/UBR4/ITGB6/GNAS/DLG1/WNT6/MDM2/ITGB5/PIK3R3/PARD6B/CTNNB1/TCF7/PATJ/ATP6V1C2/DVL3/ITGAV/CRB3/MAML3/NFX1/RBL1	3.6405797388301
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/373	148/9376	2.54764147525542	LRP5/EGFR/JAG1/HES1/NOTCH3/CDK6/CCND1/WNT6/IGF1R/PIK3R3/CTNNB1/TCF7/NCOA3/DVL3/SHC4	3.86272556271616
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	21/373	250/9376	2.11148525469169	PSD3/PIP5K1B/TFRC/EEA1/EGFR/NEDD4L/RAB11FIP1/AGAP1/RAB31/DAB2/DNAJC6/ASAP2/MDM2/IGF1R/FGFR2/PIP5K1A/PARD6B/ARRB1/CYTH3/EHD4/SMURF2	3.62560015489528
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/373	106/9376	2.84566745915322	SPINT1/EGFR/PDGFA/PLAU/CCND1/SLC19A1/MDM2/IGF1R/FGFR2/PIK3R3/CTNNB1/TCF7	3.889671724624
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/373	93/9376	2.97316152094324	EGFR/MET/PTPRM/PTPN1/IGF1R/CTNNB1/TCF7/ARHGAP29/WASF2/SMURF2/ACTN4	3.89230053272342
NA	NA	hsa04518	Integrin signaling	15/373	154/9376	2.44838271647923	LAMB4/EGFR/PDGFA/MET/FRAS1/CCND1/ITGB6/IGF1R/ITGB5/PIK3R3/CTNNB1/FERMT1/ITGAV/FERMT2/ACTN4	3.68873591540866
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	15/373	157/9376	2.40159833336179	BMP7/SMAD7/LATS2/WWC1/CCND1/DLG1/WNT6/FRMD6/PARD6B/CTNNB1/TCF7/PATJ/DVL3/YWHAZ/BMPR1A	3.60477298886033
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/373	99/9376	2.79296991361335	EGFR/JAG1/NOTCH3/CCND1/GNAS/MDM2/IGF1R/PIK3R3/NCOA3/ADCY9/SHC4	3.65033943439554
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/373	184/9376	2.1858025410887	NRP1/EPHB4/SEMA6A/BMP7/EPHA2/MET/PLXNA2/PAK6/SEMA3F/PIK3R3/ENAH/PARD6B/PLCG2/LIMK2/PLXNB1/PLXNA1	3.30645570746545
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/373	62/9376	3.24344893193808	JAG1/HES1/NOTCH3/PSEN2/TLE1/DVL3/MAML3/TLE4	3.60736714100673
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/373	76/9376	2.9767179342458	EGFR/PDGFA/CDK6/CCND1/MDM2/IGF1R/PIK3R3/PLCG2/SHC4	3.52173321533388
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	15/373	170/9376	2.21794669610472	CLDN3/EZR/JAM3/NEDD4L/OCLN/MARVELD2/CCND1/DLG1/RAPGEF6/MARVELD3/PARD6B/PATJ/CRB3/CGN/ACTN4	3.26184775033572
NA	NA	hsa04517	IgSF CAM signaling	22/373	299/9376	1.84952522707506	NRP1/ANK3/EZR/CADM1/NRCAM/JAM3/GRIP1/NRP2/PLXNA2/MTSS1/IL1RAPL2/RAPGEF6/PAK6/APP/PIK3R3/PARD6B/CTNNB1/CD2AP/PLCG2/PLXNA1/EPB41L3/ACTN4	3.0386951694113
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/373	80/9376	2.82788203753351	EGFR/PDGFA/MET/IGF1R/FGFR2/GAB1/PIK3R3/PLCG2/SHC4	3.3418852238713
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/373	232/9376	1.95026347416104	IQGAP2/PIP5K1B/EZR/EGFR/PDGFA/ITGB6/DIAPH3/FGFR2/PAK6/ITGB5/PIP5K1A/PIK3R3/ENAH/DIAPH2/ITGAV/WASF2/LIMK2/ACTN4	2.98308995113442
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	9/373	83/9376	2.72566943376724	SFMBT2/SFMBT1/TEX10/KDM2A/AUTS2/FBRS/SCML1/LCOR/RYBP	3.21414239536893
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/373	149/9376	2.19313744894471	PIP5K1B/EGFR/PDGFA/GNAS/DGKD/GAB1/PIP5K1A/PIK3R3/CYTH3/PLCG2/ADCY9/AGPAT3/SHC4	2.98813201108706
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/373	203/9376	1.98122003724296	PIP5K1B/LAMB4/EGFR/PDGFA/MET/CCND1/ITGB6/IGF1R/PAK6/ITGB5/PIP5K1A/PIK3R3/CTNNB1/ITGAV/SHC4/ACTN4	2.87677012174589
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/373	204/9376	1.9715081743153	ANK3/EZR/EGFR/PLAU/MET/CCND1/WNT6/MDM2/IGF1R/GAB1/ITGB5/PIK3R3/CTNNB1/ITGAV/PLCG2/TWIST1	2.85545913213379
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/373	73/9376	2.75471005178303	EGFR/PDGFA/MET/CDK6/CCND1/MDM2/IGF1R/PIK3R3	3.06338592443856
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/373	73/9376	2.75471005178303	EGFR/EML4/MET/CDK6/CCND1/PIK3R3/PLCG2/STAT5B	3.06338592443856
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/373	122/9376	2.26642640530919	MED12L/NOTCH3/CCND1/SLC2A1/MDM2/SLC16A2/PIK3R3/CTNNB1/NCOA3/ITGAV/PLCG2	2.86577146414894
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	14/373	178/9376	1.97704611862518	LRP5/TBL1X/ZNRF3/CCND1/WNT6/CTNNB1/TCF7/LGR5/RNF43/TLE1/DVL3/CHD8/TLE4/LGR4	2.67870440203224
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/373	150/9376	2.01093833780161	LRP5/EGFR/MET/CCND1/WNT6/FGFR2/GAB1/PIK3R3/CTNNB1/TCF7/DVL3/SHC4	2.54044618772104
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/373	99/9376	2.28515720204728	PIP5K1B/EGFR/PDGFA/SLC22A5/DGKD/PIP5K1A/PIK3R3/GPCPD1/WASF2	2.61647447534488
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/373	26/9376	3.86718911115694	SLC19A3/SLC19A2/SLC19A1/SLC52A3	2.97977612578738
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/373	56/9376	2.69322098812715	LRP2/CCND1/ARRB1/MGRN1/SMURF2/SPOPL	2.58670039524759
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/373	105/9376	2.15457679050172	GABARAPL1/RPS27A/TFEB/TFE3/ATG9B/UBA52/AMFR/SMURF2/ARIH1	2.42158998044289
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/373	17/9376	4.43589339220943	TFRC/PCDH11X/NRP2	2.88599680725194
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/373	59/9376	2.55627754805289	ADRB1/CGA/GNAS/PIK3R3/PDE3B/ADCY9	2.44073955342998
NA	NA	hsa04519	Cadherin signaling	24/373	404/9376	1.49327104292199	CDH12/KRT80/LRP5/MYO7A/DSC3/EGFR/PCDH11X/TMC5/LATS2/WWC1/MET/WNT6/MYO1D/DSP/IGF1R/ENAH/CTNNB1/PSEN2/TCF7/GABRA4/DVL3/YWHAZ/KRT18/ACTN4	2.06289964171402
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/373	78/9376	2.25586031484155	MET/GAB1/PIK3R3/CTNNB1/CD2AP/WASF2/SHC4	2.2669414134161
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/373	32/9376	3.14209115281501	GABARAPL1/ATG2A/ATG9B/ATG4D	2.47054603540876
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/373	98/9376	2.05197789571593	PIP5K1B/CDS1/DGKD/PIP5K1A/PIK3R3/PLCG2/PI4K2A/SYNJ1	2.13078140080443
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/373	116/9376	1.95026347416104	CLDN3/EZR/JAM3/OCLN/CD99/PIK3R3/CTNNB1/PLCG2/ACTN4	2.09610950176504
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/373	212/9376	1.65997268450604	EGFR/PDGFA/EPHA2/MET/GNAS/RAPGEF6/IGF1R/MAGI3/FGFR2/PIK3R3/ENAH/PARD6B/CTNNB1/ADCY9	1.9783256424045
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	11/373	155/9376	1.78389691256594	EGFR/CDK6/CCND1/GNAS/WNT6/CTNNB1/TCF7/PBX1/DVL3/NR4A1/ADCY9	2.00300586547785
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	15/373	238/9376	1.5842476400748	EGFR/PDGFA/EPHA2/MET/IGF1R/FGFR2/GAB1/PAK6/FOXO4/PIK3R3/RASAL2/EXOC2/PLCG2/RALGAPA1/SHC4	1.85825922535673
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/373	86/9376	2.0460128436935	EGFR/GAB1/PAK6/PIK3R3/PLCG2/STAT5B/SHC4	1.98346624879442
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/373	86/9376	2.0460128436935	ITGB6/DSP/ITGB5/CTNNB1/TCF7/ITGAV/CACNG4	1.98346624879442
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/373	52/9376	2.41699319447309	CGA/GNAS/IGF1R/ADCY9/HSD17B1	2.08552179498768
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/373	104/9376	1.93359455557847	CDS1/SELENOI/DGKD/GPCPD1/GPD1L/AGPAT3/ACHE/SGMS1	1.94865383972266
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/373	323/9376	1.47863113073648	TP63/EZR/EGFR/PDGFA/PLAU/NOTCH3/MET/CDK6/ST14/DNMT1/CCND1/SPRY2/MDM2/PIK3R3/RPS6KA5/MDM4/PLCG2/KIF23/SHC4	1.78177299444159
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/373	70/9376	2.15457679050172	MET/SLC2A1/GAB1/PAK6/PIK3R3/TFE3	1.97349826049056
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/373	54/9376	2.32747492801112	CDO1/DNMT1/AHCYL2/LDHB/MTR	1.99120093241248
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/373	71/9376	2.12423063852283	EGFR/MET/SLC2A1/FGFR2/PIK3R3/LDHB	1.93540933550586
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/373	75/9376	2.01093833780161	CDK6/CCND1/MDM2/PPM1D/MDM4/ZMAT3	1.78910943145228
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/373	41/9376	2.45236382658733	EGFR/CCND1/MDM2/RPS6KA5	1.89695321465485
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/373	59/9376	2.13023129004408	EGFR/CCND1/PIK3R3/CTNNB1/TCF7	1.77256313797378
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/373	77/9376	1.95870617318339	CDK6/CCND1/MDM2/PIK3R3/STAT5B/SHC4	1.71932980403178
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/373	217/9376	1.50588700411411	EGFR/ADRB1/JAG1/PAQR7/GSTA3/CCND1/GNAS/PIK3R3/ARRB1/GSTM4/KPNB1/ADCY9/STAT5B	1.53463743983864
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/373	98/9376	1.79548065875144	PIP5K1B/ASAP2/PIP5K1A/PIK3R3/PLCG2/WASF2/LIMK2	1.61124620514358
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/373	201/9376	1.50070025209075	SPINT1/PDGFA/PLAU/MET/MDM2/IGF1R/JMJD1C/TFE3/PBX1/SIX4/ETV7/DUSP6	1.46055942419227
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/373	29/9376	2.60035129888139	LATS2/WWC1/FRMD6	1.75680934655624
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/373	30/9376	2.51367292225201	SLC19A1/GGH/MTR	1.69015373721431
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/373	227/9376	1.43954836957164	MT-ND3/EGFR/COX7C/MET/SLC26A2/GSTA3/MT-CO3/PTPN1/PIK3R3/GSTM4/NDUFA1/MT-ND5/NDUFA13	1.36451783742986
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/373	144/9376	1.57104557640751	WNT6/TBX3/IGF1R/FGFR2/PIK3R3/CTNNB1/TCF7/DVL3/BMPR1A	1.40556375253958
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/373	105/9376	1.67578194816801	ADRB1/ITGB6/GNAS/ITGB5/ITGAV/ADCY9/CACNG4	1.41737371486282
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/373	68/9376	1.8482889134206	CCND1/PIK3R3/TCF7/STAT5B/DUSP6	1.42894821139114
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/373	51/9376	1.9715081743153	GNAS/ATP6V1C2/PLCG2/ADCY9	1.41596838240293
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/373	110/9376	1.5996100414331	TFRC/EGFR/SLC2A1/IGF1R/PIK3R3/PLCG2/LDHB	1.2875542030004
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/373	71/9376	1.77019219876902	CGA/CCND1/PIK3R3/STAT5B/SHC4	1.32591758359296
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/373	71/9376	1.77019219876902	EGFR/JAM3/MET/ATP6V1C2/PLCG2	1.32591758359296
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/373	91/9376	1.6573667619244	GNAS/ARRB1/GABRA4/PDE3B/ADCY9/PDE7A	1.28257837284417
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/373	133/9376	1.51198371263279	EGFR/GABARAPL1/CCND1/MDM2/IGF1R/FOXO4/PIK3R3/DEPP1	1.21038049996037
NA	NA	hsa04081	Hormone signaling	12/373	219/9376	1.37735502589151	ADRB1/SLC40A1/ADRA2C/CGA/GNAS/IGF1R/SLC16A2/PIK3R3/ITGAV/BMPR1A/ADCY9/STAT5B	1.15011698709922
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/373	156/9376	1.45019591668385	CLDN3/EGFR/CDK6/OCLN/CCND1/PIK3R3/CTNNB1/YWHAZ/IFIT1	1.15410366258463
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/373	36/9376	2.09472743521001	GALNT18/GCNT4/GALNT11	1.3394615253814
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/373	157/9376	1.44095900001708	ATP11B/ARG2/SLC2A1/SIRPA/DUSP16/ITGB5/PBX1/CD24/ITGAV	1.13410315539103
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/373	115/9376	1.53006177876209	LRP5/EGFR/GNAS/ARRB1/ADCY9/AKAP13/OXSR1	1.16410698925932
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/373	75/9376	1.67578194816801	GSTA3/MDM2/PIK3R3/GSTM4/ATP7B	1.19596597721457
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/373	37/9376	2.03811318020433	CCND1/CTNNB1/TCF7	1.28778039267003
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	12/373	227/9376	1.32881387960459	EGFR/CDK6/CCND1/GNAS/MDM2/PIK3R3/CTNNB1/CCL4/ITGAV/ADCY9/CCL4L2/AKAP13	1.02075774812276
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/373	205/9376	1.34880010462303	CDK6/CCND1/UBR4/DLG1/MDM2/PIK3R3/YWHAZ/STAT5B/SND1/RBL1/ACTN4	1.02775978287491
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	18/373	362/9376	1.24989261327448	CSF3R/LAMB4/EGFR/PDGFA/EPHA2/MET/CDK6/CCND1/ITGB6/MDM2/IGF1R/FGFR2/ITGB5/PIK3R3/YWHAZ/NR4A1/ITGAV/PHLPP2	0.986950465410237
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/373	78/9376	1.61132879631539	PIP5K1B/PIP5K1A/PLCG2/PI4K2A/SYNJ1	1.10350374894681
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/373	39/9376	1.93359455557847	GLDC/AHCYL2/MTR	1.18914102808126
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/373	142/9376	1.41615375901522	RHOBTB1/NEDD4L/RPS27A/MDM2/FBXW7/UBA52/MGRN1/SMURF2	1.0170668235641
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/373	142/9376	1.41615375901522	PDGFA/GSTA3/PIK3R3/CTNNB1/GSTM4/ITGAV/BMPR1A/DUSP1	1.0170668235641
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/373	101/9376	1.49327104292199	GNAS/WNT6/CTNNB1/TCF7/DVL3/ADCY9	1.01446198676276
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/373	233/9376	1.2945954964388	ANK3/FBN2/ITGB6/DIAPH3/DSP/ITGB5/COL5A2/DIAPH2/SUN1/ITGAV/LBR/ANKRD23	0.926842912022243
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/373	169/9376	1.33864238463125	GABARAPL1/RPS27A/IGF1R/PIK3R3/ATG2A/ATG9B/UBA52/ATG4D/UVRAG	0.904215658275872
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/373	23/9376	2.1858025410887	LARGE2/B3GALNT2	1.15890345213281
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/373	23/9376	2.1858025410887	ENPEP/MME	1.15890345213281
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/373	105/9376	1.43638452700115	PLAU/EDARADD/PARP1/CCL4/PLCG2/CCL4L2	0.91526558207279
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/373	63/9376	1.59598280777905	WNT6/CTNNB1/TCF7/DVL3	0.966063411818881
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/373	65/9376	1.54687564446278	GNAS/PBX1/NR4A1/ADCY9	0.900520339041484
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/373	65/9376	1.54687564446278	KCNN4/CGA/PIK3R3/ARRB1	0.900520339041484
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/373	87/9376	1.44463961048966	EGFR/CCND1/PIK3R3/CTNNB1/TCF7	0.848066138107161
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/373	110/9376	1.37109432122837	TFRC/BMP7/SMAD7/BMPR1A/SMURF2/RBL1	0.796857991012279
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/373	155/9376	1.29737957277523	OLR1/TFRC/EEA1/PLA2R1/COLEC12/ITGB5/ATP6V1C2/ITGAV	0.759861429473328
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/373	89/9376	1.41217579901798	LAMB4/FRAS1/ITGB6/ITGB5/ITGAV	0.795217993041815
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/373	89/9376	1.41217579901798	EGFR/ADRB1/PDGFA/GNAS/ADCY9	0.795217993041815
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/373	47/9376	1.6044720780332	ME1/ACACA/LDHB	0.845578741721368
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/373	158/9376	1.27274578341874	LRP5/WNT6/CAB39L/IGF1R/CLIP1/PIK3R3/ATP6V1C2/DVL3	0.703743936298207
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/373	48/9376	1.57104557640751	MCCC2/IVD/MCCC1	0.80731598307761
NA	NA	hsa03272	Virion - Hepatitis viruses	3/373	48/9376	1.57104557640751	CLDN3/EGFR/OCLN	0.80731598307761
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	10/373	205/9376	1.22618191329366	MT-ND3/COX7C/MT-CO3/PARP1/SLC2A1/PIK3R3/NDUFA1/MPC2/MT-ND5/NDUFA13	0.666458154730666
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/373	160/9376	1.25683646112601	CLDN3/CADM1/NRCAM/JAM3/OCLN/PTPRM/CD99/ITGAV	0.666947831124902
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/373	253/9376	1.19225593150293	EGFR/CAST/RPS27A/MDM2/FOXO4/PIK3R3/UBA52/CYTH3/RPS6KA5/PLCG2/WASF2/ACTN4	0.630982914529314
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/373	28/9376	1.79548065875144	GCNT2/B3GALNT1	0.858016654041466
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/373	138/9376	1.27505148230174	MT-ND3/COX7C/MT-CO3/NDUFA1/ATP6V1C2/MT-ND5/NDUFA13	0.662538290906948
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/373	93/9376	1.3514370549742	KCNN4/ADRB1/ATP2B4/GNAS/ADCY9	0.693252235955283
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/373	93/9376	1.3514370549742	LAMB4/CDK6/CCND1/PIK3R3/ITGAV	0.693252235955283
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/373	254/9376	1.18756201051276	EGFR/ADRB1/PDGFA/MET/ATP2B4/GNAS/FGFR2/ORAI3/TFEB/PLCG2/ADCY9/TPCN1	0.616826655143708
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/373	139/9376	1.26587845005497	EGFR/GNAS/PIK3R3/NCOA3/ADCY9/SHC4/KRT18	0.642793528488138
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/373	30/9376	1.67578194816801	PGAP1/PIGG	0.754572119542722
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/373	120/9376	1.25683646112601	GAB1/PIK3R3/PSEN2/RPS6KA5/PLCG2/SHC4	0.576344371629315
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/373	75/9376	1.34062555853441	LRP2/CGA/GNAS/ADCY9	0.602822522976865
NA	NA	hsa04981	Folate transport and metabolism	2/373	31/9376	1.62172446596904	SLC19A1/MTR	0.705725127823833
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/373	53/9376	1.42283372957661	ATP2B4/GNAS/ADCY9	0.628313144733405
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/373	122/9376	1.2362325847141	GNAS/PIK3R3/PLCG2/ADCY9/STAT5B/SHC4	0.534566080853741
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/373	76/9376	1.32298574855369	OLR1/SLC27A6/ACADL/ME1	0.575433459197605
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/373	32/9376	1.57104557640751	ACACA/LDHB	0.658606139602085
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/373	77/9376	1.30580411545559	EGFR/CDK6/CCND1/PIK3R3	0.548424683813731
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/373	78/9376	1.28906303705231	DHX36/TOB1/BTG3/DIS3L	0.521784916712173
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/373	103/9376	1.22022957390874	LAMB4/ARG2/GNAS/PIK3R3/ACTN4	0.457436220811405
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/373	57/9376	1.32298574855369	ACADL/HACD3/ACACA	0.497831715550783
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/373	130/9376	1.16015673334708	EGFR/GNAS/PIK3R3/ARRB1/ADCY9/SHC4	0.374271159576118
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/373	300/9376	1.0892582663092	EGFR/PDGFA/EPHA2/MET/IGF1R/FGFR2/DUSP16/ARRB1/RPS6KA5/NR4A1/CACNG4/DUSP1/DUSP6	0.319821944868336
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/373	107/9376	1.17461351507103	GNAS/SLC2A1/PDE3B/ACACA/LDHB	0.369742805180194
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/373	61/9376	1.2362325847141	SLC40A1/ATP2B4/ATP7B	0.376755602091888
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/373	158/9376	1.1136525604914	CDK6/CCND1/MDM2/YWHAZ/STAG1/RBL1/CDC14A	0.293248530877528
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/373	110/9376	1.14257860102364	IGF1R/PIK3R3/CPEB4/PDE3B/ADCY9	0.306161779024158
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/373	86/9376	1.16915019639628	KCNN4/GNAS/SLC2A1/ADCY9	0.320745302078992
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/373	38/9376	1.32298574855369	NEDD4L/PIK3R3	0.406064153395832
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/373	62/9376	1.21629334947678	IGF1R/PIK3R3/ADCY9	0.347790186178552
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/373	15/9376	1.67578194816801	TPK1	0.53313540240093
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/373	16/9376	1.57104557640751	B3GALNT1	0.465306658848086
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/373	17/9376	1.47863113073648	CDO1	0.402028746959638
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/373	17/9376	1.47863113073648	MTR	0.402028746959638
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/373	117/9376	1.07421919754359	INO80/SMARCA2/ARID2/SMARCA5/BAZ2A	0.164427166294952
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/373	42/9376	1.19698710583429	TFRC/SLC40A1	0.260420384315426
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/373	193/9376	1.04193696259151	PIK3R3/ARRB1/CCL4/PLCG2/ADCY9/STAT5B/CCL4L2/SHC4	0.119820123692305
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/373	93/9376	1.08114964397936	JAG1/NOTCH3/MAML3/STAT5B	0.160077519827259
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/373	93/9376	1.08114964397936	EGFR/CGA/GNAS/ADCY9	0.160077519827259
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/373	18/9376	1.39648495680667	ACACA	0.342702975655986
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/373	18/9376	1.39648495680667	MTR	0.342702975655986
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/373	69/9376	1.09290127054435	ADRB1/GNAS/PDE3B	0.157647747922944
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/373	196/9376	1.02598894785796	CDK6/CCND1/RPS27A/PIK3R3/CTNNB1/TCF7/UBA52/PLCG2	0.0748413860385145
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/373	44/9376	1.14257860102364	TDG/PARP1	0.192947764564411
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/373	44/9376	1.14257860102364	GNAS/ADCY9	0.192947764564411
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/373	122/9376	1.03019382059509	CCND1/CAB39L/IGF1R/PIK3R3/ACACA	0.0683250041947015
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/373	19/9376	1.32298574855369	GLDC	0.28683904948332
NA	NA	hsa04082	Neuroactive ligand signaling	8/373	199/9376	1.01052177778975	ADRB1/TAC3/ADRA2C/SLC6A4/GNAS/GABRA4/ADCY9/ACHE	0.0305359704762919
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/373	149/9376	1.01221728412833	MT-ND3/NDUFA1/GABRA4/MT-ND5/ADCY9/NDUFA13	0.0305973614562908
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/373	98/9376	1.02598894785796	ATP2B4/GNAS/NR4A1/ADCY9	0.0526406181610291
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/373	20/9376	1.25683646112601	LBR	0.234030789421672
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/373	99/9376	1.01562542313213	GNAS/PIK3R3/PLCG2/ADCY9	0.031812077718229
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/373	99/9376	1.01562542313213	ITGB6/ITGB5/ITGAV/CACNG4	0.031812077718229
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/373	100/9376	1.0054691689008	CSF3R/TFRC/MME/CD24	0.0111914766947352
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/373	21/9376	1.19698710583429	CHST11	0.183938220241609
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/373	101/9376	0.995514028614658	CCND1/PIK3R3/PLCG2/STAT5B	-0.00922585566178239
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/373	154/9376	0.979353086591693	ADRB1/ATP2B4/GNAS/RPS6KA5/ADCY9/CACNG4	-0.0525834851279439
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	15/373	388/9376	0.97178076891186	MT-ND3/LRP5/COX7C/MT-CO3/WNT6/MME/APP/PIK3R3/ATG2A/CTNNB1/PSEN2/NDUFA1/DVL3/MT-ND5/NDUFA13	-0.11555159270887
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/373	49/9376	1.02598894785796	GALNT18/GALNT11	0.0371246338014866
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/373	76/9376	0.992239311415267	EZR/GNAS/ADCY9	-0.0138264920296497
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/373	103/9376	0.976183659126994	KCNN4/MME/COL5A2/KCNK5	-0.0494686375183118
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/373	235/9376	0.962683246819919	MT-ND3/COX7C/MT-CO3/GNAS/NDUFA1/SMARCA2/MT-ND5/ADCY9/NDUFA13	-0.117919968836539
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/373	157/9376	0.960639333344717	CDK6/CCND1/MDM2/PIK3R3/LIN54/RBL1	-0.101231761343621
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/373	23/9376	1.09290127054435	ARG2	0.0907938711638503
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/373	23/9376	1.09290127054435	IDI1	0.0907938711638503
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/373	24/9376	1.047363717605	HS6ST2	0.0472874161143277
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/373	268/9376	0.93793765755672	MT-ND3/COX7C/MT-CO3/RPS27A/GNAS/NDUFA1/UBA52/MT-ND5/NDUFA13/DUSP1	-0.209812074759638
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/373	109/9376	0.922448778808077	SLC27A6/PTPN1/SLC2A1/PIK3R3	-0.165759618104537
NA	NA	hsa04382	Cornified envelope formation	8/373	217/9376	0.926699694839451	CLDN3/KRT80/ST14/OCLN/SPTLC3/DSP/DST/KRT18	-0.222360708490553
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/373	54/9376	0.930989971204448	HES1/FANCA	-0.103514447455058
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	5/373	137/9376	0.91739887673431	PARP1/PIK3R3/CTSC/CTSV/CASP6	-0.198234930211142
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/373	138/9376	0.91075105878696	PTPN1/PIK3R3/PDE3B/ACACA/SHC4	-0.214980993673296
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/373	83/9376	0.908556477922414	CCL4/CCL4L2/ZDHHC1	-0.170317962026944
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/373	55/9376	0.914062880818913	SPTLC3/SGMS1	-0.130100004261802
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/373	26/9376	0.966797277789235	HES1	-0.0345065062397876
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/373	140/9376	0.897740329375718	JAG1/NOTCH3/CCND1/PDE3B/ADCY9	-0.248126342731137
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/373	168/9376	0.897740329375718	CSF3R/EGFR/PDGFA/CCND1/PIK3R3/STAT5B	-0.272221739074062
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/373	27/9376	0.930989971204448	HACD3	-0.0730899962906801
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	9/373	250/9376	0.904922252010724	BORCS7/AP4S1/TFEB/TFE3/CTSC/ATP6V1C2/CTSV/TPCN1/CLN8	-0.310138075500275
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/373	86/9376	0.876862647297213	GABRA4/SCN2A/KCNK5	-0.233495013492816
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/373	224/9376	0.897740329375718	NRP1/MSX2/CCND1/DLG1/SLC2A1/PIK3R3/ADCY9/STAT5B	-0.315294810027185
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/373	115/9376	0.874321016435482	SLC6A4/GNAS/APP/DUSP1	-0.276012700844305
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/373	87/9376	0.866783766293797	COX7C/MT-CO3/CACNG4	-0.254084823275158
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/373	28/9376	0.897740329375718	HACD3	-0.110298722498349
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/373	28/9376	0.897740329375718	GGH	-0.110298722498349
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/373	28/9376	0.897740329375718	ATP6V1C2	-0.110298722498349
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/373	144/9376	0.87280309800417	CCND1/CTNNB1/TCF7/TRA2B/ACACA	-0.313080710659572
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/373	59/9376	0.852092516017631	GSTA3/GSTM4	-0.231966108394832
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/373	89/9376	0.84730547941079	GABARAPL1/GABRA4/ADCY9	-0.294596214772269
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/373	60/9376	0.837890974084003	PIK3R3/PLCG2	-0.256397927552981
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/373	60/9376	0.837890974084003	GNAS/IGF1R	-0.256397927552981
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/373	90/9376	0.837890974084003	IGF1R/PIK3R3/ADCY9	-0.31452888855204
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/373	90/9376	0.837890974084003	GNAS/SLC2A1/ADCY9	-0.31452888855204
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/373	90/9376	0.837890974084003	EGFR/EML4/PIK3R3	-0.31452888855204
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/373	31/9376	0.81086223298452	GLDC	-0.214692009257299
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/373	65/9376	0.773437822231388	DGKD/AGPAT3	-0.373071741636237
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/373	125/9376	0.804375335120643	SPTLC3/PIK3R3/S1PR3/SGMS1	-0.448157538334173
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/373	154/9376	0.816127572159744	EGFR/CCND1/GNAS/ADCY9/CACNG4	-0.468285640743122
Organismal Systems	Immune system	hsa04611	Platelet activation	4/373	126/9376	0.797991403889527	GNAS/PIK3R3/PLCG2/ADCY9	-0.464655075819828
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/373	66/9376	0.761719067349094	STS/HSD17B1	-0.395396524519421
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/373	97/9376	0.777424615129488	GNAS/RPS6KA5/ADCY9	-0.448496276520785
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/373	34/9376	0.739315565368238	CRY1	-0.309942446275562
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/373	157/9376	0.800532777787265	COX7C/MT-CO3/PIK3R3/NDUFA1/NDUFA13	-0.513010066921837
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/373	128/9376	0.785522788203753	GMPR/PDE3B/ADCY9/PDE7A	-0.497288777548685
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/373	35/9376	0.718192263500575	PMM2	-0.339966932643288
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/373	100/9376	0.754101876675603	CCL4/TNFRSF10D/CCL4L2	-0.503177569824072
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/373	69/9376	0.728600847029568	PIK3R3/PLCG2	-0.460547686843063
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/373	36/9376	0.698242478403336	AGL	-0.369217557880642
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/373	70/9376	0.718192263500575	GSTA3/GSTM4	-0.481689119640732
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/373	102/9376	0.739315565368238	ATP2B4/GNAS/ADCY9	-0.538800598564205
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/373	37/9376	0.679371060068111	RIMKLB	-0.397740506565566
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/373	37/9376	0.679371060068111	PMM2	-0.397740506565566
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/373	38/9376	0.661492874276845	PMM2	-0.42557793971018
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/373	73/9376	0.688677512945756	GSTA3/GSTM4	-0.543509124960039
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/373	105/9376	0.718192263500575	MDM2/PIK3R3/PLCG2	-0.591058816297313
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/373	136/9376	0.739315565368238	CDK6/CCND1/PIK3R3/STAT5B	-0.623296944606759
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/373	166/9376	0.757130398268678	ADRB1/ADRA2C/ATP2B4/PDE3B/ADCY9	-0.642604583025768
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/373	226/9376	0.778571259104605	ADRB1/CGA/ATP2B4/GNAS/PIK3R3/PDE3B/ADCY9	-0.685842023580463
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/373	138/9376	0.728600847029568	IGF1R/CPEB4/YWHAZ/ADCY9	-0.653740635963417
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/373	138/9376	0.728600847029568	PIP5K1B/PIP5K1A/PIK3R3/WASF2	-0.653740635963417
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/373	75/9376	0.670312779267203	ARG2/MTR	-0.583464385498545
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/373	41/9376	0.613090956646832	GLDC	-0.505347448161396
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/373	41/9376	0.613090956646832	GABRA4	-0.505347448161396
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/373	200/9376	0.754101876675603	CLDN3/EZR/OCLN/MYO1D/CYTH3/WASF2	-0.715467545933607
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/373	109/9376	0.691836584106058	PIK3R3/CCL4/CCL4L2	-0.658674993730336
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/373	43/9376	0.584575098198142	ACADL	-0.555728346520009
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/373	79/9376	0.63637289170937	GSTA3/GSTM4	-0.660609494881842
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/373	79/9376	0.63637289170937	SLC6A4/ATP6V1C2	-0.660609494881842
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	6/373	205/9376	0.735709147976198	HES1/CDK6/CCND1/MDM2/PIK3R3/PLCG2	-0.778748357846316
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/373	45/9376	0.558593982722669	ABCB8	-0.604125044871105
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/373	115/9376	0.655740762326611	PIK3R3/ADCY9/ACHE	-0.756052597545512
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/373	82/9376	0.613090956646832	GSTA3/GSTM4	-0.716243843340863
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/373	116/9376	0.650087824720348	SHANK2/GNAS/ADCY9	-0.771843025992866
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/373	47/9376	0.534824026011066	PIK3R3	-0.650721396502572
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/373	85/9376	0.591452452294591	CTPS2/GMPR	-0.7701357249548
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/373	119/9376	0.633699056029919	JAG1/PIK3R3/RPS6KA5	-0.818507787426355
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/373	48/9376	0.523681858802502	PIK3R3	-0.673395021878507
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/373	49/9376	0.512994473928982	GNAS	-0.695676558877962
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	15/373	480/9376	0.785522788203753	MT-ND3/LRP5/COX7C/MT-CO3/RPS27A/WNT6/APP/ATG2A/CTNNB1/PSEN2/NDUFA1/UBA52/DVL3/MT-ND5/NDUFA13	-0.98186282177688
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/373	154/9376	0.652902057727795	CTPS2/TPK1/GGH/PMM2	-0.8839877963583
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/373	50/9376	0.502734584450402	ARG2	-0.71758273499131
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/373	50/9376	0.502734584450402	MET	-0.71758273499131
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/373	122/9376	0.618116292357052	DLG1/PAK6/PIK3R3	-0.864157149123377
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/373	88/9376	0.571289300511821	F5/PLAU	-0.822414926953552
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/373	51/9376	0.492877043578826	SELENOI	-0.73912921297771
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/373	52/9376	0.483398638894617	LRP2	-0.760330679150655
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/373	91/9376	0.552455587308134	PIK3R3/PLCG2	-0.873197152416788
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/373	54/9376	0.465494985602224	CGA	-0.801752907410903
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/373	194/9376	0.64785384594124	MYO7A/KIF13B/KIFC3/MYO1D/KIF23	-1.00879193011616
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/373	133/9376	0.566993892237296	PIK3R3/PLCG2/SHC4	-1.02366957437886
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/373	59/9376	0.426046258008815	CTPS2	-0.900142523851036
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/373	174/9376	0.577855844195865	ERO1B/HSPA4L/AMFR/SVIP	-1.14403871090585
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/373	103/9376	0.488091829563497	GNAS/PIK3R3	-1.06327835417775
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/373	63/9376	0.398995701944764	AASS	-0.974203039280118
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/373	63/9376	0.398995701944764	LTC4S	-0.974203039280118
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/373	63/9376	0.398995701944764	XPC	-0.974203039280118
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/373	142/9376	0.531057659630707	SIRPA/PIK3R3/PLCG2	-1.1460804719937
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	7/373	275/9376	0.639844016573239	MT-ND3/COX7C/MT-CO3/PIK3R3/NDUFA1/MT-ND5/NDUFA13	-1.23384002124809
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/373	308/9376	0.652902057727795	MT-ND3/COX7C/MT-CO3/ATG2A/NDUFA1/MT-ND5/NDUFA13/TGM2	-1.2607183397004
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/373	108/9376	0.465494985602224	NUP210/KPNB1	-1.13714822570337
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/373	67/9376	0.375175063022688	LDHB	-1.04469777389845
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/373	216/9376	0.58186873200278	OLR1/POU2F1/PIK3R3/CASP6/MIB1	-1.26543025351714
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/373	68/9376	0.369657782684119	ALDH1A3	-1.06181557927689
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/373	69/9376	0.364300423514784	GNAS	-1.07874312160907
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/373	70/9376	0.359096131750287	SLC2A1	-1.09548596467355
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/373	70/9376	0.359096131750287	CCND1	-1.09548596467355
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/373	116/9376	0.433391883146898	GLDC/ME1	-1.24983511395252
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/373	73/9376	0.344338756472878	AFF4	-1.14465829985981
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/373	298/9376	0.59046008240819	CSF3R/BMP7/CCL4/TNFRSF10D/BMPR1A/CCL4L2/TNFRSF12A	-1.46236475165744
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/373	163/9376	0.462639188144542	PIK3R3/YWHAZ/STAT5B	-1.40865839261647
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/373	368/9376	0.614756964681198	MT-ND3/COX7C/MT-CO3/CHCHD10/ATG2A/NDUFA1/NUP210/MT-ND5/NDUFA13	-1.53458498866701
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/373	83/9376	0.302852159307471	CROT	-1.29847141449224
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/373	133/9376	0.377995928158197	GNAS/ARRB1	-1.47047958924671
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/373	134/9376	0.375175063022688	GNAS/ADCY9	-1.48277139830241
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/373	214/9376	0.469845406028413	PAK6/PIK3R3/PLCG2/LIMK2	-1.59683741932279
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/373	94/9376	0.267412013005533	USP25	-1.45294564180576
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/373	95/9376	0.264597149710738	ATP6V1C2	-1.46634497123297
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/373	144/9376	0.349121239201668	PIK3R3/ATG2A	-1.60206405805893
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/373	187/9376	0.403263035655403	GABARAPL1/CARD18/CARD8	-1.67770673203903
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/373	99/9376	0.253906355783031	KRT18	-1.51898536085776
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/373	103/9376	0.244045914781749	MSI2	-1.57018321250746
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/373	109/9376	0.230612194702019	STAT5B	-1.64450574498193
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/373	112/9376	0.22443508234393	LAMB4	-1.68063855720052
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	4/373	248/9376	0.40543111649226	CTNNB1/TCF7/CYTH3/EXOC2	-1.93146405662625
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/373	168/9376	0.299246776458573	PARP1/STAT5B	-1.86544959522788
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/373	370/9376	0.475559742047678	ADRB1/TAC3/ADRA2C/CGA/NPFFR2/GABRA4/S1PR3	-2.09496775131111
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/373	173/9376	0.290598025693874	CDK6/PIK3R3	-1.91688987030809
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/373	180/9376	0.279296991361335	POU2F1/PIK3R3	-1.98719065119833
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/373	181/9376	0.277753914060996	EEA1/PLA2R1	-1.99707808813259
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/373	191/9376	0.263211824319582	GNAS/SHC4	-2.09394938561555
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/373	195/9376	0.257812607410463	PIK3R3/PLCG2	-2.13173057284626
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/373	243/9376	0.310329990401483	DDX46/SNIP1/TRA2B	-2.21709436447004
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/373	143/9376	0.175781323234406	ACTN4	-2.02155462667191
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/373	449/9376	0.0559838067316706	ARRB1	-4.17249933580793