category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	44/299	308/9376	4.47969421882465	GPX3/UQCRFS1/ATP5PO/SDHD/PSMA6/PSMA3/PSMA5/ATP5F1C/PPIF/UQCRC2/COX7A2L/VDAC1/CYC1/VDAC2/NDUFA10/PSMC6/VDAC3/POLR2H/COX7B2/SOD1/ATP5MC2/ATP5MC3/HDAC1/PSMB1/NDUFA8/PSMD4/PSMA1/ADRM1/POLR2C/NDUFB10/PSMA4/SLC25A5/NDUFV2/PSMC4/NDUFS4/ATP5MC1/NDUFV1/PSMA2/PSMB3/DCTN6/SDHC/PSMC2/PSMC3/NDUFA9	11.2696583128069
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/299	268/9376	4.797284480607	UQCRFS1/ATP5PO/SDHD/PSMA6/PSMA3/PSMA5/ATP5F1C/PPIF/TXN2/UQCRC2/COX7A2L/VDAC1/CYC1/VDAC2/PARK7/NDUFA10/PSMC6/VDAC3/COX7B2/SOD1/ATP5MC2/ATP5MC3/PSMB1/NDUFA8/PSMD4/PSMA1/ADRM1/NDUFB10/PSMA4/SLC25A5/NDUFV2/PSMC4/NDUFS4/ATP5MC1/NDUFV1/PSMA2/PSMB3/SDHC/PSMC2/PSMC3/NDUFA9	11.4466679558338
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	41/299	275/9376	4.675171784737	CAV1/UQCRFS1/ATP5PO/SDHD/PSMA6/PSMA3/PSMA5/ATP5F1C/PPIF/UQCRC2/COX7A2L/HSPA8/VDAC1/CYC1/VDAC2/NDUFA10/PSMC6/VDAC3/COX7B2/SOD1/ATP5MC2/ATP5MC3/PSMB1/NDUFA8/PSMD4/PSMA1/ADRM1/NDUFB10/PSMA4/SLC25A5/NDUFV2/PSMC4/NDUFS4/ATP5MC1/NDUFV1/PSMA2/PSMB3/SDHC/PSMC2/PSMC3/NDUFA9	11.226632284024
Genetic Information Processing	Translation	hsa03010	Ribosome	36/299	222/9376	5.08505830244961	RPSA/RPL10/RPL3/RPS5/RPL8/RPL7A/RPS3/MRPS6/RACK1/MRPS34/RPS3A/RPL18A/RPL15/RPS4X/RPL5/RPL14/MRPS2/MRPL16/MRPS12/RPL6/RPS7/RPL18/MRPS17/MRPL14/MRPS27/MRPL43/MRPL47/MRPS16/MRPL40/RPL4/MRPL4/RPL19/MRPL45/RSL24D1/MRPL39/RPS2	11.1794221765133
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	17/299	46/9376	11.5887741747855	PSMA6/PSMA3/PSMA5/PSMC6/POMP/PSMB1/PSMD4/PSMA1/ADRM1/PSMA4/PSMC4/PSME2/PSMA2/PSMB3/PSMC2/PSMC3/PSME1	13.0657349795332
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	41/299	368/9376	3.49367456739857	CAT/GPX3/HNRNPA1/UQCRFS1/ATP5PO/SDHD/PSMA6/PSMA3/PSMA5/ATP5F1C/UQCRC2/COX7A2L/PFN1/VDAC1/ALYREF/CYC1/NDUFA10/PSMC6/COX7B2/SOD1/ATP5MC2/ATP5MC3/PSMB1/NDUFA8/PSMD4/PSMA1/ADRM1/NDUFB10/PSMA4/NDUFV2/PSMC4/NDUFS4/ATP5MC1/NDUFV1/PSMA2/PSMB3/DCTN6/SDHC/PSMC2/PSMC3/NDUFA9	8.8572634239836
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/299	227/9376	4.28235086116718	CAT/UQCRFS1/ATP5PO/SDHD/ATP5F1C/HMOX1/PPIF/UQCRC2/COX7A2L/VDAC1/CYC1/VDAC2/NDUFA10/VDAC3/COX7B2/SOD1/GSTO1/MAP2K2/ATP5MC2/ATP5MC3/AKR1A1/MGST3/NDUFA8/NDUFB10/SLC25A5/NDUFV2/NDUFS4/ATP5MC1/NDUFV1/SDHC/NDUFA9	9.08575834788084
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	41/299	388/9376	3.31358824949143	GAPDH/UQCRFS1/ATP5PO/SDHD/PSMA6/PSMA3/PSMA5/ATP5F1C/PPIF/UQCRC2/COX7A2L/VDAC1/CYC1/VDAC2/NDUFA10/PSMC6/VDAC3/COX7B2/MAP2K2/ATP5MC2/ATP5MC3/HSD17B10/PSMB1/NDUFA8/PSMD4/PSMA1/ADRM1/NDUFB10/PSMA4/SLC25A5/NDUFV2/PSMC4/NDUFS4/ATP5MC1/NDUFV1/PSMA2/PSMB3/SDHC/PSMC2/PSMC3/NDUFA9	8.44734954704279
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	45/299	480/9376	2.93979933110368	CAT/GPX3/UQCRFS1/ATP5PO/SDHD/PSMA6/PSMA3/PSMA5/ATP5F1C/PPIF/UQCRC2/COX7A2L/VDAC1/CYC1/VDAC2/PARK7/NDUFA10/PSMC6/VDAC3/COX7B2/SOD1/MAP2K2/ATP5MC2/ATP5MC3/HSD17B10/PSMB1/NDUFA8/PSMD4/PSMA1/ADRM1/NDUFB10/PSMA4/SLC25A5/NDUFV2/PSMC4/NDUFS4/ATP5MC1/NDUFV1/PSMA2/PSMB3/DCTN6/SDHC/PSMC2/PSMC3/NDUFA9	7.9182662632446
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	21/299	116/9376	5.67685388075193	CAT/GAPDH/IDH1/ECHS1/SDHD/RPIA/ACSS1/TKT/TPI1/TALDO1/MDH1/IDH3A/GCSH/PGAM1/ADH5/SUCLG1/PGD/SDHC/ALDOA/ESD/PDHB	9.19871931755529
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	27/299	205/9376	4.13005954808712	GAPDH/UQCRFS1/ATP5PO/SDHD/ATP5F1C/PPIF/UQCRC2/COX7A2L/VDAC1/CYC1/VDAC2/NDUFA10/VDAC3/COX7B2/ATP5MC2/ATP5MC3/NDUFA8/PPP1CA/NDUFB10/SLC25A5/NDUFV2/NDUFS4/ATP5MC1/NDUFV1/SDHC/PDHB/NDUFA9	8.22377554335296
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	21/299	138/9376	4.77184818961757	UQCRFS1/ATP5PO/SDHD/ATP5F1C/UQCRC2/COX7A2L/CYC1/NDUFA10/COX7B2/ATP5MC2/ATP5MC3/NDUFA8/NDUFB10/NDUFV2/NDUFS4/ATP5MC1/NDUFV1/ATP6V1F/PPA1/SDHC/NDUFA9	8.10130221662306
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/299	144/9376	4.13749535488666	PSMA6/PSMA3/PSMA5/PPIF/VDAC1/VDAC2/PSMC6/VDAC3/PSMB1/PSMD4/PSMA1/ADRM1/PSMA4/SLC25A5/PSMC4/PSMA2/PSMB3/PSMC2/PSMC3	6.88599184898918
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/299	67/9376	5.14830529626117	GAPDH/LDHA/ACSS1/TPI1/PGAM1/AKR1A1/ADH5/ALDH7A1/LDHB/ALDOA/PDHB	6.18452944848796
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/299	238/9376	2.76686995868582	RPSA/RPL10/RPL3/RPS5/RPL8/RPL7A/RPS3/RPS3A/RPL18A/RPL15/RPS4X/RPL5/RPL14/RPL6/RPS7/RPL18/CFD/RPL4/RPL19/RSL24D1/RPS2	5.01092096648947
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/299	75/9376	4.59915273132664	GAPDH/IDH1/RPIA/TKT/TPI1/BCAT2/TALDO1/IDH3A/ASS1/PGAM1/ALDOA	5.67957907714904
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	7/299	30/9376	7.31683389074693	IDH1/SDHD/MDH1/IDH3A/SUCLG1/SDHC/PDHB	6.28922685756598
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	20/299	235/9376	2.66875400270405	UQCRFS1/ATP5PO/SDHD/ATP5F1C/UQCRC2/COX7A2L/CYC1/NDUFA10/COX7B2/ATP5MC2/ATP5MC3/RHEB/NDUFA8/NDUFB10/NDUFV2/NDUFS4/ATP5MC1/NDUFV1/SDHC/NDUFA9	4.70196575435996
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/299	47/9376	5.3375080054081	LDHA/ACSS1/MDH1/AKR1A1/ADH5/ALDH7A1/LDHB/PDHB	5.41030484729761
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	10/299	85/9376	3.68915994491442	APRT/AK2/NTPCR/IMPDH2/PNP/DGUOK/HDDC2/GUK1/AK6/DCTPP1	4.52006761354697
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/299	32/9376	5.87959866220736	ECHS1/LDHA/ACSS1/SUCLG1/LDHB/ECHDC1	5.01813964237058
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	14/299	157/9376	2.79624225124087	UQCRFS1/SDHD/UQCRC2/COX7A2L/CYC1/NDUFA10/COX7B2/NDUFA8/NDUFB10/NDUFV2/NDUFS4/NDUFV1/SDHC/NDUFA9	4.11929496482173
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/299	59/9376	4.25191315685052	GPX3/IDH1/GSTP1/GSTO1/MGST3/PGD/GGCT/SRM	4.54754454508308
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/299	128/9376	2.93979933110368	APRT/NUDT2/AK2/NTPCR/HDDC3/IMPDH2/PNP/DGUOK/HDDC2/GUK1/ATIC/AK6	4.01040233219942
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/299	83/9376	3.40024982874642	CAT/PRDX1/IDH1/PHYH/SOD1/HSD17B4/FAR2/SCP2/FAR1	3.98627806280529
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/299	224/9376	2.23984710941233	CCND3/CCNE1/MSX1/VDAC1/VDAC2/FDPS/VDAC3/RANBP1/MAP2K2/NFYB/ANAPC16/SLC25A5/ANAPC13/CDK4/CCND2/MAD2L1	3.4086640629009
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/299	31/9376	5.05771927931816	RPIA/TKT/TALDO1/PGD/ALDOA	4.10698632816046
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/299	48/9376	3.91973244147157	ECHS1/BCAT2/HADHB/HSD17B10/ALDH7A1/HIBADH	3.68060718855045
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/299	158/9376	2.38160958469159	CCND3/CCNE1/YWHAH/HDAC1/ANAPC16/ANAPC13/MCM3/CDK4/CCND2/PPP2CA/MCM5/MAD2L1	3.17867110180398
Genetic Information Processing	Transcription	hsa03040	Spliceosome	16/299	243/9376	2.06471503089861	HNRNPA1/LSM6/SNRNP40/HSPA8/SNRPD1/ALYREF/SRSF9/LSM4/SNRPA1/THOC7/PLRG1/SRSF10/DDX39B/NCBP2/SNRPA/HNRNPC	3.05196717130471
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/299	54/9376	3.4842066146414	ADI1/LDHA/BCAT2/MDH1/LDHB/SRM	3.32261567109988
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/299	39/9376	4.0202384015093	DHFR/GCSH/MTHFS/ALDH7A1/ATIC	3.43020372288926
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/299	43/9376	3.64626273625262	ECHS1/ACADVL/HADHB/ADH5/ALDH7A1	3.15650601152491
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/299	157/9376	2.19704748311782	CCND3/CCNE1/VDAC1/VDAC2/VDAC3/MAP2K2/RHEB/PPP1CA/SLC25A5/CDK4/CCND2	2.74517073988956
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/299	31/9376	4.04617542345453	CAT/ACSS1/MDH1/GCSH	3.08316075019571
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/299	33/9376	3.80095267051789	IDH1/BCAT2/IDH3A/PDHB	2.9252947416158
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/299	52/9376	3.01517880113198	NPC2/VDAC1/VDAC2/VDAC3/LRPAP1	2.64462555340872
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/299	71/9376	2.64995996043148	IDH1/LDHA/MAP2K2/PGAM1/LDHB/PDHB	2.53276243100828
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	12/299	205/9376	1.83558202137205	CCND3/CCNE1/PSMC6/HDAC1/PSMD4/ADRM1/PSMC4/CDK4/CCND2/PSMC2/PSMC3/TRADD	2.19537005167343
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/299	75/9376	2.50862876254181	CCND3/CCNE1/SIVA1/CDK4/CCND2/CCNG1	2.38066483823802
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/299	57/9376	2.75068943261163	ECHS1/ACADVL/HADHB/HSD17B4/SCP2	2.40609043642733
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/299	42/9376	2.98646281254977	CAT/ECHS1/ALDH7A1/AOC1	2.34164605352947
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/299	42/9376	2.98646281254977	HMOX1/VDAC2/VDAC3/SAT1	2.34164605352947
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/299	44/9376	2.85071450288842	MBD4/UNG/APEX1/POLE4	2.23320435494659
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/299	174/9376	1.80217583515934	TUSC3/SSR2/HSPA8/PDIA6/BAG2/HERPUD1/UBE2D2/UBXN1/NSFL1C/DNAJB12	1.93844351033582
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/299	108/9376	2.03245385854082	EEF1A1/SUMO1/ALYREF/UBE2I/THOC7/DDX39B/NCBP2	1.95857218048336
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/299	110/9376	1.99550015202189	GAPDH/LDHA/HMOX1/MAP2K2/LDHB/ALDOA/PDHB	1.90608204316926
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/299	205/9376	1.68261685292438	CCND3/CCNE1/YWHAH/VDAC3/RANBP1/HDAC1/GTF2A2/CDK4/CCND2/HDAC3/TRADD	1.79347635222812
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/299	50/9376	2.50862876254181	ALDH7A1/SAT1/AOC1/SRM	1.94119759544821
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/299	15/9376	4.18104793756968	AK2/NTPCR	2.23771506355654
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/299	142/9376	1.76663997362099	CAV1/GSTP1/HMOX1/TXN2/SUMO1/GSTO1/ASS1/MGST3	1.67067033778955
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/299	168/9376	1.67988533205925	PPIA/VDAC1/VDAC2/VDAC3/RBCK1/SLC25A5/CHMP1B/TRADD/CHMP2A	1.61382976772522
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/299	35/9376	2.68781653129479	AKR1B1/TPI1/ALDOA	1.81556849114325
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/299	17/9376	3.68915994491442	HSD17B4/SCP2	2.01407869498276
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/299	17/9376	3.68915994491442	SEPHS1/TXNRD2	2.01407869498276
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/299	36/9376	2.61315496098105	AKR1B1/DCXR/AKR1A1	1.75996473169678
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/299	36/9376	2.61315496098105	POLE4/MCM3/MCM5	1.75996473169678
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/299	79/9376	1.98467465390966	GSTP1/GSTO1/ADH5/MGST3/AKR7A2	1.59508912415082
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/299	103/9376	1.8266714290353	SSU72/ALYREF/PPP1CA/DDX39B/NCBP2/PPP2CA	1.53105740793068
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/299	18/9376	3.4842066146414	PRDX1/THAP11	1.9146196445963
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/299	37/9376	2.5425291512248	COMT/ADH5/GSTZ1	1.70621642810981
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/299	38/9376	2.47562048935047	NAPRT/QPRT/PNP	1.65420605066798
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/299	19/9376	3.30082731913396	GCSH/PDHB	1.82197568044749
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/299	107/9376	1.75838464664145	LDHA/PGAM1/LDHB/PPP4C/PRMT1/PDHB	1.43190776635017
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/299	62/9376	2.02308771172726	CAT/HSPA8/SOD1/HDAC1	1.46686673856488
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/299	41/9376	2.29447752671507	GCSH/PGAM1/ALDH7A1	1.50757645791316
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/299	136/9376	1.61400747590006	CCND3/RACK1/CCNE1/HSPA8/CDK4/CCND2/TRADD	1.30905288505785
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/299	87/9376	1.80217583515934	UQCRFS1/UQCRC2/COX7A2L/CYC1/COX7B2	1.36425258264881
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/299	138/9376	1.59061606320586	CCNE1/YWHAH/ANAPC16/PPP1CA/ANAPC13/PPP2CA/MAD2L1	1.26854501599332
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/299	22/9376	2.85071450288842	ALDH7A1/AOC1	1.57725586331737
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/299	44/9376	2.13803587716631	TAF10/GTF2A2/TAF9	1.37323540341138
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/299	23/9376	2.72677039406718	FDPS/FNTA	1.50478034319227
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/299	142/9376	1.54580997691837	UBE2I/ANAPC16/UBE2D2/CDC34/ANAPC13/UBE2F/UBE2M	1.1894351584619
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	11/299	248/9376	1.39087280181249	GAPDH/RPS3/BRK1/TXN2/PFN1/DYNLT1/MAP2K2/ARPC1B/ANXA2/DCTN6/TRADD	1.13220101848421
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/299	149/9376	1.47318803169401	NDUFA10/NDUFA8/NDUFB10/NDUFV2/NDUFS4/NDUFV1/NDUFA9	1.05668779211485
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/299	73/9376	1.71823887845329	GSTP1/GSTO1/ADH5/MGST3	1.1180697411568
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/299	27/9376	2.32280440976093	HSD17B4/SCP2	1.24923746639034
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/299	154/9376	1.42535725144421	NAPRT/AK2/DHFR/BCAT2/QPRT/AKR1A1/AK6	0.965943461598173
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/299	28/9376	2.23984710941233	ECHS1/HADHB	1.192443641973
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/299	28/9376	2.23984710941233	AKR1B1/DHFR	1.192443641973
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/299	156/9376	1.40708344052826	CD81/YWHAH/EIF3E/MAP2K2/CDK4/TRADD/PPP2CA	0.930529915247826
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/299	30/9376	2.09052396878484	DHFR/ATIC	1.08575795278512
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/299	133/9376	1.41464027962884	CAT/MAP2K2/BNIP3/PRMT1/FOXO4/CCND2	0.874059298493418
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/299	31/9376	2.02308771172726	AKR1A1/ALDH7A1	1.03550959426619
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/299	31/9376	2.02308771172726	ECHS1/ALDH7A1	1.03550959426619
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/299	31/9376	2.02308771172726	SRP9/SPCS2	1.03550959426619
NA	NA	hsa04981	Folate transport and metabolism	2/299	31/9376	2.02308771172726	DHFR/MTHFS	1.03550959426619
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/299	56/9376	1.67988533205925	EEF1A1/HSPA8/BNIP3	0.926129661447299
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/299	82/9376	1.52965168447671	GSTP1/IMPDH2/GSTO1/MGST3	0.874270882683819
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/299	82/9376	1.52965168447671	HSPA8/NFYB/PSME2/PSME1	0.874270882683819
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/299	166/9376	1.32231937784583	PPIF/VDAC1/VDAC2/VDAC3/MAP2K2/PPP1CA/SLC25A5	0.760432569720164
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/299	195/9376	1.28647628848298	PPIF/VDAC1/VDAC2/VDAC3/MAP2K2/HDAC1/SLC25A5/HDAC3	0.733687395405715
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	10/299	253/9376	1.23944108821235	PFN1/VDAC1/ARPC1B/UBE2D2/ILK/RBCK1/BNIP3/FOXO4/TRADD/UBE2V2	0.700712984807928
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/299	59/9376	1.59446743381894	NUDT2/HDDC2/DCTPP1	0.831315907129296
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/299	34/9376	1.84457997245721	POLR2H/POLR2C	0.89538614610349
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/299	170/9376	1.29120598072005	GSTP1/HMOX1/GSTO1/MAP2K2/MGST3/CDK4/TXNRD2	0.695407435891256
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/299	173/9376	1.26881512556305	CCND3/VDAC1/FDPS/MAP2K2/SLC25A5/CDK4/TRADD	0.647682416643372
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/299	63/9376	1.49323140627488	POLR2H/POLR2C/POLE4	0.712896135025922
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/299	37/9376	1.69501943414987	NIT2/ASS1	0.768772230632075
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/299	65/9376	1.44728582454335	AKR1B1/AKR1A1/ALDH7A1	0.656740371500941
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/299	41/9376	1.52965168447671	MAP2K2/CDK4	0.616843779773782
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/299	157/9376	1.19838953624609	UQCRFS1/BSG/MAP2K2/P2RY6/CD47/CD24	0.45496369833594
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/299	157/9376	1.19838953624609	CCND3/MOB1A/YWHAH/PPP1CA/CCND2/PPP2CA	0.45496369833594
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/299	70/9376	1.3439082656474	GSTP1/GSTO1/MGST3	0.524155532933647
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	9/299	250/9376	1.12888294314381	AP1S1/NPC2/VPS29/LAMTOR1/CLN3/FUCA1/LAPTM4B/ATP6V1F/CTSF	0.374865335055724
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	9/299	250/9376	1.12888294314381	CAV1/ARF5/VPS29/HSPA8/ARPC1B/CAPZA2/CHMP1B/WASHC3/CHMP2A	0.374865335055724
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/299	17/9376	1.84457997245721	CA8	0.632558331813664
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/299	75/9376	1.2543143812709	GSTP1/GSTO1/MGST3	0.401316294891414
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/299	105/9376	1.19458512501991	CCZ1B/FKBP8/MTX2/BNIP3	0.363907546124137
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/299	76/9376	1.23781024467523	PLIN2/SCP2/ILK	0.37778607520661
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/299	18/9376	1.7421033073207	FUCA1	0.571951448056665
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/299	77/9376	1.22173478695218	MAP2K2/HDAC1/CDK4	0.354577469515308
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/299	78/9376	1.20607152045279	LSM6/LSM4/EXOSC3	0.331680981967182
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/299	78/9376	1.20607152045279	CAV1/ARPC1B/ILK	0.331680981967182
NA	NA	hsa03272	Virion - Hepatitis viruses	2/299	48/9376	1.30657748049052	CD81/CHMP1B	0.38647078153928
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/299	20/9376	1.56789297658863	FDFT1	0.461409416580453
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/299	21/9376	1.49323140627488	BCAT2	0.410665801711107
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/299	83/9376	1.13341660958214	HDAC1/UBE2D2/RBBP7	0.221575145062674
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/299	180/9376	1.04526198439242	ALYREF/NECTIN2/SRSF9/RHEB/PPP1CA/TRADD	0.111280847986959
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/299	23/9376	1.36338519703359	ASS1	0.316669143379999
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/299	23/9376	1.36338519703359	ATP6AP2	0.316669143379999
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/299	23/9376	1.36338519703359	MDH1	0.316669143379999
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/299	24/9376	1.30657748049052	EXTL2	0.272925231405819
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/299	122/9376	1.02812654202533	MAP2K2/HDAC1/RHEB/HDAC3	0.0567520526682717
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/299	187/9376	1.00613453043121	TXN2/VDAC1/VDAC2/VDAC3/SUGT1/RBCK1	0.0153786448410631
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/299	59/9376	1.06297828921263	MAP2K2/ILK	0.0880701795385379
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/299	158/9376	0.992337326954828	PRR5/LAMTOR1/MAP2K2/RHEB/ATP6V1F	-0.0176295225808646
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/299	60/9376	1.04526198439242	MAP2K2/PPP2CA	0.0638328948661434
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/299	27/9376	1.16140220488047	ECHS1	0.152425921781684
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/299	61/9376	1.02812654202533	HMOX1/MT2A	0.0399981490386319
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/299	28/9376	1.11992355470616	B3GNT3	0.115338479435539
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/299	28/9376	1.11992355470616	ATP6V1F	0.115338479435539
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/299	63/9376	0.995487604183256	ECHS1/ALDH7A1	-0.00652202900411187
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/299	29/9376	1.08130550109561	MOB1A	0.0795853028046853
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/299	333/9376	0.941677463416594	CCND3/CCNE1/MAP2K2/HDAC1/RHEB/CDK4/ATP6V1F/CCND2/TRADD/PPP2CA	-0.196676431649554
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/299	66/9376	0.950238167629472	COMT/HSD17B1	-0.0736280936164423
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/299	203/9376	0.926833286653377	CCND3/CAV1/ILK/PPP1CA/CCND2/PARVA	-0.191273997213076
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/299	67/9376	0.936055508411122	MAP2K2/PPP1CA	-0.0953320845638917
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/299	204/9376	0.922289986228605	CAV1/LUM/MAP2K2/PDCD4/PPP1CA/DCN	-0.203662050149103
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/299	32/9376	0.979933110367893	AKR1B1	-0.0206366263565617
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/299	32/9376	0.979933110367893	PPP2CA	-0.0206366263565617
Human Diseases	Immune disease	hsa05310	Asthma	1/299	32/9376	0.979933110367893	PRG2	-0.0206366263565617
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/299	69/9376	0.90892346468906	HDAC1/PPP1CA	-0.137808578852412
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/299	139/9376	0.902384446957484	HSPA8/FKBP4/KRT10/MAP2K2	-0.210431626532768
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/299	106/9376	0.887486590521865	GSTP1/CCNE1/MAP2K2	-0.2114303922227
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/299	71/9376	0.883319986810495	MAP2K2/CCND2	-0.179109045639293
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/299	144/9376	0.871051653660349	ACADVL/ADH5/ALDH7A1/TRADD	-0.283008311216303
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/299	73/9376	0.859119439226646	PPIA/MLLT1	-0.219306273780517
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/299	73/9376	0.859119439226646	MAP2K2/CDK4	-0.219306273780517
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/299	73/9376	0.859119439226646	MAP2K2/CDK4	-0.219306273780517
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/299	110/9376	0.855214350866525	HDAC1/DCN/PPP2CA	-0.277220777276037
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/299	110/9376	0.855214350866525	ANAPC16/ANAPC13/MAD2L1	-0.277220777276037
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/299	36/9376	0.871051653660349	B3GNT3	-0.140683658580692
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/299	112/9376	0.839942666029623	IL10RB/PPIF/HSPA8	-0.309268281755485
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/299	37/9376	0.847509717074934	MAP2K2	-0.168671966845664
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/299	76/9376	0.825206829783489	MAP2K2/CDK4	-0.277676959792867
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/299	323/9376	0.873748408006047	CCNE1/HMOX1/UBE2I/MAP2K2/HDAC1/PDCD4/STMN1/CCND2/CCNG1	-0.41907516894453
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/299	38/9376	0.825206829783489	UNG	-0.195947346810605
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/299	78/9376	0.804047680301861	ISYNA1/TPI1	-0.31539369279859
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/299	117/9376	0.804047680301861	HDAC1/MORF4L2/RBBP7	-0.387089474597074
NA	NA	hsa04518	Integrin signaling	4/299	154/9376	0.814489857968119	CCND3/ILK/CCND2/PARVA	-0.421274841671173
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/299	122/9376	0.771094906518998	MAP2K2/CDK4/PPP2CA	-0.461870993937688
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/299	44/9376	0.712678625722104	TUSC3	-0.346702499659031
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/299	44/9376	0.712678625722104	DCTN6	-0.346702499659031
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/299	125/9376	0.752588628762542	MAP2K2/TRADD/PPP2CA	-0.505394355233843
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/299	200/9376	0.783946488294314	GAPDH/RPS3/BRK1/ARPC1B/TRADD	-0.560531069145445
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/299	46/9376	0.681692598516795	HMOX1	-0.392766913445641
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/299	88/9376	0.712678625722104	SERPINE2/CFD	-0.491471379855039
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/299	90/9376	0.696841322928279	CAT/RHEB	-0.524477646301504
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/299	91/9376	0.689183725973024	CD81/MAP2K2	-0.540733849249981
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/299	169/9376	0.742197858740179	MAP2K2/RHEB/BNIP3/PPP2CA	-0.613791493926012
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/299	133/9376	0.707320139814419	COMT/PPP1CA/PPP2CA	-0.616967443457146
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/299	93/9376	0.674362570575754	CCNE1/CDK4	-0.57277187096229
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/299	50/9376	0.627157190635452	CD81	-0.479747955884914
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/299	51/9376	0.61485999081907	ATP6V1F	-0.500529142757144
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/299	52/9376	0.603035760226396	HSD17B1	-0.520957133781394
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/299	137/9376	0.686668456900129	MAP2K2/TRADD/CTSF	-0.670504940447835
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/299	138/9376	0.681692598516795	MAP2K2/RHEB/PPP1CA	-0.683671327043752
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/299	54/9376	0.580701102440233	CENPX	-0.560810473531443
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/299	217/9376	0.72253132561688	CCND3/PTGES3/GSTO1/MAP2K2/MGST3	-0.7505331192114
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/299	99/9376	0.633492111752981	MAP2K2/CDK4	-0.66534547855063
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/299	99/9376	0.633492111752981	KRT10/CFD	-0.66534547855063
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/299	99/9376	0.633492111752981	MAP2K2/RHEB	-0.66534547855063
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/299	56/9376	0.559961777353082	TUSC3	-0.599413505406157
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/299	56/9376	0.559961777353082	CCND2	-0.599413505406157
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/299	183/9376	0.685417694683554	IMP3/EIF6/NOP10/AK6	-0.779976054896443
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/299	144/9376	0.653288740245262	DUSP9/DLX5/MAP2K2	-0.760941655230002
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/299	103/9376	0.608890476345099	PRDX1/SERPINB6	-0.72436413364724
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/299	105/9376	0.597292562509954	UBE2I/TRADD	-0.75313195378089
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/299	227/9376	0.690701751801158	IL10RB/MAP2K2/RHEB/CDK4/TRADD	-0.856157449163817
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/299	60/9376	0.52263099219621	MAP2K2	-0.673232649795138
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/299	62/9376	0.505771927931816	HDAC1	-0.708606614928366
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/299	232/9376	0.675815938184754	BRK1/PFN1/MAP2K2/ARPC1B/PPP1CA	-0.907439349554399
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/299	63/9376	0.497743802091628	PTGES3	-0.725940193034146
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/299	155/9376	0.606926313518179	CCNE1/MAP2K2/CDK4	-0.895572758071276
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/299	65/9376	0.482428608181117	MAP2K2	-0.759939192100306
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/299	68/9376	0.461144993114303	ADH5	-0.809372149498536
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/299	68/9376	0.461144993114303	MAP2K2	-0.809372149498536
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/299	69/9376	0.45446173234453	MAP2K2	-0.825457985622087
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/299	163/9376	0.577138518989679	CCNE1/VDAC3/MAP2K2	-0.98841984820235
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/299	362/9376	0.692991370867902	CCND3/CCNE1/YWHAH/MAP2K2/RHEB/CDK4/CCND2/PPP2CA	-1.08117539957512
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/299	70/9376	0.447969421882465	TRADD	-0.841357742083267
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/299	70/9376	0.447969421882465	MAP2K2	-0.841357742083267
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/299	70/9376	0.447969421882465	CAV1	-0.841357742083267
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/299	71/9376	0.441659993405248	ATP6V1F	-0.857076914801185
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/299	72/9376	0.435525826830175	TRADD	-0.872620754533111
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/299	122/9376	0.514063271012665	RHEB/PPP2CA	-0.980494040543648
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/299	168/9376	0.559961777353082	CCND3/IL10RB/CCND2	-1.04450963884394
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	3/299	170/9376	0.553373991737163	ARPC1B/CDK4/PPP2CA	-1.06655449328491
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/299	254/9376	0.617280699444342	PPIF/VDAC1/VDAC2/VDAC3/SLC25A5	-1.12228266111699
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/299	75/9376	0.418104793756968	GPX3	-0.918249400672991
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/299	77/9376	0.407244928984059	CDK4	-0.947878300974615
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/299	78/9376	0.40202384015093	EEF1A1	-0.962468367564361
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/299	79/9376	0.396934930781931	ATP6V1F	-0.976914079432838
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/299	80/9376	0.391973244147157	MAP2K2	-0.991219166685007
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/299	178/9376	0.528503250535493	CCND3/CBY1/CCND2	-1.15263569883841
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/299	134/9376	0.468027754205561	MAP2K2/PPP1CA	-1.12566316901827
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/299	181/9376	0.519743528150927	IL10RB/NFYB/TRADD	-1.18409544736467
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/299	83/9376	0.37780553652738	POLR2H	-1.0333258275182
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/299	138/9376	0.45446173234453	MAP2K2/ARPC1B	-1.17172541280302
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/299	86/9376	0.364626273625263	MAP2K2	-1.07428790306487
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/299	87/9376	0.360435167031869	MAP2K2	-1.08770164458371
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/299	89/9376	0.352335500356995	CD47	-1.11418533505512
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/299	89/9376	0.352335500356995	MAP2K2	-1.11418533505512
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/299	143/9376	0.438571461982833	SNRPD1/SSB	-1.22783822618132
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/299	191/9376	0.492531825106375	HDAC1/PPP1CA/HDAC3	-1.28598522604474
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/299	90/9376	0.34842066146414	MAP2K2	-1.1272604866696
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/299	194/9376	0.484915353584112	DYNLT1/CAPZA2/DCTN6	-1.31571216467242
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/299	93/9376	0.337181285287877	NECTIN2	-1.16584852056388
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/299	93/9376	0.337181285287877	MAP2K2	-1.16584852056388
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/299	196/9376	0.479967237731213	MAP2K2/CDK4/TRADD	-1.33532649117698
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/299	148/9376	0.423754858537467	MAP2K2/CDK4	-1.28243217680081
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/299	94/9376	0.333594250338006	TRADD	-1.17850639864679
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/299	149/9376	0.42091086619829	MAP2K2/RHEB	-1.29317813902429
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/299	95/9376	0.330082731913395	ATP6V1F	-1.1910655226325
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/299	150/9376	0.418104793756968	CCNE1/MAP2K2	-1.30386836506879
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/299	201/9376	0.468027754205561	MLLT1/HDAC1/CCND2	-1.38367480051419
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/299	98/9376	0.319978158487475	ARPC1B	-1.228170835707
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/299	154/9376	0.407244928984059	PPP1CA/PPP2CA	-1.34608704385074
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/299	154/9376	0.407244928984059	MAP2K2/PPP1CA	-1.34608704385074
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/299	99/9376	0.316746055876491	PPP1CA	-1.24035508375763
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/299	100/9376	0.313578595317726	IL10RB	-1.25245033230055
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/299	100/9376	0.313578595317726	CD24	-1.25245033230055
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/299	101/9376	0.310473856750223	MAP2K2	-1.26445835207953
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/299	101/9376	0.310473856750223	CDK4	-1.26445835207953
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/299	103/9376	0.304445238172549	PPP2CA	-1.28821951904172
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/299	300/9376	0.52263099219621	DUSP9/HSPA8/MAP2K2/STMN1/TRADD	-1.52516794265392
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/299	104/9376	0.301517880113198	PISD	-1.29997594497127
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/299	214/9376	0.439596161660363	AP1S1/MAP2K2/TRADD	-1.50509151984735
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/299	109/9376	0.287686784695161	MAP2K2	-1.35757781980589
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/299	109/9376	0.287686784695161	PPP1CA	-1.35757781980589
NA	NA	hsa04519	Cadherin signaling	7/299	404/9376	0.543329249312891	BRK1/MOB1A/YWHAH/KRT10/MAP2K2/ARPC1B/PPP1CA	-1.70293986059391
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/299	119/9376	0.263511424636744	TRADD	-1.46741997924159
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/299	120/9376	0.261315496098105	MAP2K2	-1.4780461794814
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	3/299	233/9376	0.403749264357587	CSRP2/CAPZA2/DCN	-1.67267895625769
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/299	122/9376	0.257031635506333	MAP2K2	-1.49911708714961
Organismal Systems	Immune system	hsa04611	Platelet activation	1/299	126/9376	0.248871901045814	PPP1CA	-1.54055951133148
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/299	130/9376	0.241214304090558	MAP2K2	-1.58111672090979
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/299	133/9376	0.23577337993814	MAP2K2	-1.61098527142419
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/299	140/9376	0.223984710941233	MAP2K2	-1.67896792003243
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/299	212/9376	0.295828863507288	PFN1/MAP2K2	-1.88214758372037
NA	NA	hsa04382	Cornified envelope formation	2/299	217/9376	0.289012530246752	KRT10/PPP2CA	-1.92317076722441
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	1/299	155/9376	0.202308771172726	ATP6V1F	-1.81744685146495
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/299	160/9376	0.195986622073579	NECTIN2	-1.86166741769615
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/299	226/9376	0.277503181697102	MAP2K2/PPP1CA	-1.99539865932544
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	2/299	238/9376	0.263511424636744	MAP2K2/FOXO4	-2.08871401413868
NA	NA	hsa04517	IgSF CAM signaling	3/299	299/9376	0.314627353161598	NECTIN2/MAP2K2/ARPC1B	-2.18595520903993
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/299	184/9376	0.170423149629199	ILK	-2.06257900483554
NA	NA	hsa04082	Neuroactive ligand signaling	1/299	199/9376	0.157577183576747	P2RY6	-2.17999931874306
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	1/299	216/9376	0.145175275610058	HSPA8	-2.30678053605526
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/299	298/9376	0.105227716549572	IL10RB	-2.84888966919981
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/299	370/9376	0.0847509717074934	P2RY6	-3.26004978121062