ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 32/476 175/18639 0.182857142857143 7.16024009603842 1.4672032906646e-18 1.06959119889449e-15 GO:0009055 electron transfer activity 19/476 116/18639 0.163793103448276 6.41373877137062 1.12601982555872e-10 4.10434226416152e-08 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 17/476 122/18639 0.139344262295082 5.45638173302108 1.3703704824389e-08 3.33000027232652e-06 GO:0016209 antioxidant activity 14/476 86/18639 0.162790697674419 6.37448700410397 3.50740744008845e-08 5.51253350467834e-06 GO:0045296 cadherin binding 28/476 334/18639 0.0838323353293413 3.28266995420923 3.97765056404934e-08 5.51253350467834e-06 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 17/476 132/18639 0.128787878787879 5.04301948051948 4.53706461290398e-08 5.51253350467834e-06 GO:0015078 proton transmembrane transporter activity 20/476 185/18639 0.108108108108108 4.23325005677947 5.98815127074436e-08 6.23623182338948e-06 GO:0019843 rRNA binding 12/476 65/18639 0.184615384615385 7.22908855850032 7.90766668480391e-08 7.20586126652756e-06 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 11/476 68/18639 0.161764705882353 6.33431166584281 1.10742028966613e-06 8.97010434629563e-05 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 10/476 61/18639 0.163934426229508 6.41927262708362 3.01419009627504e-06 0.00021973445801845 GO:0004601 peroxidase activity 9/476 57/18639 0.157894736842105 6.1827731092437 1.29743152190921e-05 0.000859843254065287 GO:0016853 isomerase activity 16/476 180/18639 0.0888888888888889 3.48067226890756 1.5976346881563e-05 0.000970563073054953 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/476 59/18639 0.152542372881356 5.97318758011679 1.73212256707709e-05 0.000971321039537847 GO:0003743 translation initiation factor activity 8/476 51/18639 0.156862745098039 6.14236282748393 4.13989176909724e-05 0.00215570078547992 GO:0008135 translation factor activity, RNA binding 10/476 83/18639 0.120481927710843 4.71777867773615 4.92717804296124e-05 0.00218648843124842 GO:0022853 active monoatomic ion transmembrane transporter activity 12/476 118/18639 0.101694915254237 3.9821250534112 4.93493116883757e-05 0.00218648843124842 GO:0043021 ribonucleoprotein complex binding 15/476 177/18639 0.0847457627118644 3.31843754450933 5.09880704132004e-05 0.00218648843124842 GO:0180051 translation factor activity 10/476 84/18639 0.119047619047619 4.66161464585834 5.46741626466323e-05 0.00221430358718861 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 7/476 40/18639 0.175 6.85257352941176 6.08910626591371e-05 0.00233629393044795 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/476 41/18639 0.170731707317073 6.68543758967001 7.18280439214531e-05 0.00261813220093697 GO:0016859 cis-trans isomerase activity 7/476 42/18639 0.166666666666667 6.52626050420168 8.43168489626795e-05 0.00292699918541873 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 8/476 58/18639 0.137931034482759 5.40104317589105 0.000106605821670111 0.0034575865824414 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 12/476 128/18639 0.09375 3.67102153361345 0.000109087093821882 0.0034575865824414 GO:0003954 NADH dehydrogenase activity 7/476 44/18639 0.159090909090909 6.22961229946524 0.000114609366826627 0.00348125951735881 GO:0043022 ribosome binding 11/476 112/18639 0.0982142857142857 3.84583208283313 0.000138435919953966 0.00403679142585766 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/476 46/18639 0.152173913043478 5.95875959079284 0.000153195297354738 0.00429536045275399 GO:0016829 lyase activity 15/476 200/18639 0.075 2.93681722689076 0.000200855622996325 0.00542310182090078 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 6/476 36/18639 0.166666666666667 6.52626050420168 0.000273076400265738 0.00663575652645743 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 6/476 36/18639 0.166666666666667 6.52626050420168 0.000273076400265738 0.00663575652645743 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 6/476 36/18639 0.166666666666667 6.52626050420168 0.000273076400265738 0.00663575652645743 GO:0050661 NADP binding 7/476 54/18639 0.12962962962963 5.07598039215686 0.000425275228171299 0.00976797844863501 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 6/476 39/18639 0.153846153846154 6.02424046541694 0.000428772716538162 0.00976797844863501 GO:0044183 protein folding chaperone 8/476 75/18639 0.106666666666667 4.17680672268908 0.000643109425100193 0.0142068718453952 GO:0016835 carbon-oxygen lyase activity 8/476 79/18639 0.10126582278481 3.96532283799596 0.000910174743145187 0.0195152172868483 GO:0051082 unfolded protein binding 10/476 121/18639 0.0826446280991736 3.23616223348844 0.00108503353434628 0.0225996984725267 GO:0015399 primary active transmembrane transporter activity 12/476 166/18639 0.072289156626506 2.83066720664169 0.00117314760898718 0.0232416807621544 GO:0050145 nucleoside monophosphate kinase activity 4/476 19/18639 0.210526315789474 8.2436974789916 0.00120006100861531 0.0232416807621544 GO:0051059 NF-kappaB binding 5/476 32/18639 0.15625 6.11836922268908 0.00121150050612053 0.0232416807621544 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 6/476 48/18639 0.125 4.89469537815126 0.00132912558409926 0.0248444243797015 GO:0033218 amide binding 15/476 247/18639 0.0607287449392713 2.37798965740142 0.00178535628942564 0.0325381183747823 GO:0016651 oxidoreductase activity, acting on NAD(P)H 8/476 88/18639 0.0909090909090909 3.55977845683728 0.00183804283386406 0.0326812981923635 GO:0031072 heat shock protein binding 10/476 131/18639 0.0763358778625954 2.98912694848932 0.00197516849838066 0.0342832817933214 GO:0051087 protein-folding chaperone binding 10/476 134/18639 0.0746268656716418 2.9222061959112 0.00233448220809826 0.0389883809180719 GO:0015485 cholesterol binding 6/476 54/18639 0.111111111111111 4.35084033613445 0.00246017218413074 0.0389883809180719 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 6/476 54/18639 0.111111111111111 4.35084033613445 0.00246017218413074 0.0389883809180719 GO:0051287 NAD binding 6/476 54/18639 0.111111111111111 4.35084033613445 0.00246017218413074 0.0389883809180719 GO:0004602 glutathione peroxidase activity 4/476 23/18639 0.173913043478261 6.8100109609061 0.0025290028487653 0.0392264484414873 GO:0048027 mRNA 5'-UTR binding 4/476 24/18639 0.166666666666667 6.52626050420168 0.00297430679999419 0.0438251403091633 GO:0019207 kinase regulator activity 16/476 287/18639 0.0557491289198606 2.18300002928 0.0030234129794468 0.0438251403091633 GO:0004032 aldose reductase (NADPH) activity 3/476 12/18639 0.25 9.78939075630252 0.00306595631792501 0.0438251403091633 GO:0004300 enoyl-CoA hydratase activity 3/476 12/18639 0.25 9.78939075630252 0.00306595631792501 0.0438251403091633 GO:0015036 disulfide oxidoreductase activity 5/476 40/18639 0.125 4.89469537815126 0.00334947698449416 0.0469570908018508 GO:0051540 metal cluster binding 7/476 77/18639 0.0909090909090909 3.55977845683728 0.00349709072809796 0.0481014932223285 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/476 41/18639 0.121951219512195 4.77531256405001 0.00373606924392455 0.0504369347929815 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/476 13/18639 0.230769230769231 9.0363606981254 0.00391074174043147 0.0509094772995454 GO:0019104 DNA N-glycosylase activity 3/476 13/18639 0.230769230769231 9.0363606981254 0.00391074174043147 0.0509094772995454 GO:0004364 glutathione transferase activity 4/476 27/18639 0.148148148148148 5.80112044817927 0.00462494986472152 0.0591506745856489 GO:0019205 nucleobase-containing compound kinase activity 5/476 44/18639 0.113636363636364 4.4497230710466 0.00508677923149329 0.0639355527544588 GO:0051537 2 iron, 2 sulfur cluster binding 4/476 28/18639 0.142857142857143 5.59393757503001 0.00528860805097671 0.0653456825281698 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/476 15/18639 0.2 7.83151260504202 0.00599014221317776 0.0727802278901097 GO:0019887 protein kinase regulator activity 14/476 255/18639 0.0549019607843137 2.14982698961938 0.00610972601393523 0.0730162338386686 GO:0005496 steroid binding 8/476 108/18639 0.0740740740740741 2.90056022408964 0.00648538050241704 0.0762555223590648 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/476 30/18639 0.133333333333333 5.22100840336134 0.00680059631266816 0.0786926144751602 GO:0008142 oxysterol binding 3/476 16/18639 0.1875 7.34204306722689 0.00723430262682372 0.082403228358664 GO:0032934 sterol binding 6/476 68/18639 0.0882352941176471 3.45507909045971 0.00773870054605494 0.0867925030472931 GO:0004659 prenyltransferase activity 3/476 17/18639 0.176470588235294 6.91015818091943 0.008620085890694 0.0937916808106855 GO:0016018 cyclosporin A binding 3/476 17/18639 0.176470588235294 6.91015818091943 0.008620085890694 0.0937916808106855 GO:0008308 voltage-gated monoatomic anion channel activity 3/476 18/18639 0.166666666666667 6.52626050420168 0.010150748074318 0.108821990384968 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/476 52/18639 0.0961538461538462 3.76515029088559 0.0103144250063724 0.10897414245863 GO:0015035 protein-disulfide reductase activity 4/476 34/18639 0.117647058823529 4.60677212061295 0.0106245205049114 0.109088386592682 GO:0030332 cyclin binding 4/476 34/18639 0.117647058823529 4.60677212061295 0.0106245205049114 0.109088386592682 GO:0016860 intramolecular oxidoreductase activity 5/476 53/18639 0.0943396226415094 3.69410971935944 0.0111561283901239 0.112955799950005 GO:1901681 sulfur compound binding 14/476 275/18639 0.0509090909090909 1.99347593582888 0.0114511169433745 0.114354304818082 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/476 19/18639 0.157894736842105 6.1827731092437 0.0118290018991373 0.114977898459614 GO:0097001 ceramide binding 3/476 19/18639 0.157894736842105 6.1827731092437 0.0118290018991373 0.114977898459614 GO:0017069 snRNA binding 5/476 54/18639 0.0925925925925926 3.62570028011204 0.0120434708601232 0.115522240224077 GO:0004033 aldo-keto reductase (NADPH) activity 4/476 36/18639 0.111111111111111 4.35084033613445 0.0129678495682416 0.118919543455967 GO:0055106 ubiquitin-protein transferase regulator activity 4/476 36/18639 0.111111111111111 4.35084033613445 0.0129678495682416 0.118919543455967 GO:0051536 iron-sulfur cluster binding 6/476 76/18639 0.0789473684210526 3.09138655462185 0.0130501556604628 0.118919543455967 GO:0098631 cell adhesion mediator activity 6/476 76/18639 0.0789473684210526 3.09138655462185 0.0130501556604628 0.118919543455967 GO:0043024 ribosomal small subunit binding 3/476 20/18639 0.15 5.87363445378151 0.0136570494476964 0.122913445029267 GO:0140297 DNA-binding transcription factor binding 21/476 488/18639 0.0430327868852459 1.68505906460945 0.0143695661724822 0.127748948045604 GO:0016504 peptidase activator activity 5/476 57/18639 0.087719298245614 3.43487394957983 0.0149897802613345 0.131657226632685 GO:1904047 S-adenosyl-L-methionine binding 3/476 21/18639 0.142857142857143 5.59393757503001 0.015636613382754 0.133542028350814 GO:0000049 tRNA binding 6/476 80/18639 0.075 2.93681722689076 0.0164872266461237 0.133542028350814 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/476 39/18639 0.102564102564103 4.01616031027796 0.0170596602256621 0.133542028350814 GO:0033192 calmodulin-dependent protein phosphatase activity 6/476 81/18639 0.0740740740740741 2.90056022408964 0.0174352811230493 0.133542028350814 GO:0140791 histone H2AXS140 phosphatase activity 6/476 81/18639 0.0740740740740741 2.90056022408964 0.0174352811230493 0.133542028350814 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 6/476 81/18639 0.0740740740740741 2.90056022408964 0.0174352811230493 0.133542028350814 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 6/476 81/18639 0.0740740740740741 2.90056022408964 0.0174352811230493 0.133542028350814 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 6/476 81/18639 0.0740740740740741 2.90056022408964 0.0174352811230493 0.133542028350814 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 6/476 81/18639 0.0740740740740741 2.90056022408964 0.0174352811230493 0.133542028350814 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 6/476 81/18639 0.0740740740740741 2.90056022408964 0.0174352811230493 0.133542028350814 GO:1990439 MAP kinase serine/threonine phosphatase activity 6/476 81/18639 0.0740740740740741 2.90056022408964 0.0174352811230493 0.133542028350814 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/476 22/18639 0.136363636363636 5.33966768525592 0.0177689667352935 0.133542028350814 GO:0061133 endopeptidase activator activity 3/476 22/18639 0.136363636363636 5.33966768525592 0.0177689667352935 0.133542028350814 GO:0140517 protein-RNA adaptor activity 3/476 22/18639 0.136363636363636 5.33966768525592 0.0177689667352935 0.133542028350814 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 6/476 82/18639 0.0731707317073171 2.86518753843001 0.0184201175389437 0.134128882643983 GO:0033549 MAP kinase phosphatase activity 6/476 82/18639 0.0731707317073171 2.86518753843001 0.0184201175389437 0.134128882643983 GO:0050997 quaternary ammonium group binding 4/476 40/18639 0.1 3.91575630252101 0.0185830139191252 0.134128882643983 GO:0140662 ATP-dependent protein folding chaperone 4/476 40/18639 0.1 3.91575630252101 0.0185830139191252 0.134128882643983 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 6/476 83/18639 0.072289156626506 2.83066720664169 0.0194423413595842 0.138846976122109 GO:0016836 hydro-lyase activity 5/476 61/18639 0.0819672131147541 3.20963631354181 0.0196176111667726 0.138846976122109 GO:0008171 O-methyltransferase activity 3/476 23/18639 0.130434782608696 5.10750822067958 0.0200549613182727 0.140577565394431 GO:0017018 myosin phosphatase activity 6/476 84/18639 0.0714285714285714 2.79696878751501 0.020502540992068 0.1423462131735 GO:0004857 enzyme inhibitor activity 18/476 416/18639 0.0432692307692308 1.69431763089851 0.0212887100359861 0.146410090719187 GO:0031492 nucleosomal DNA binding 4/476 42/18639 0.0952380952380952 3.72929171668667 0.0218759293100988 0.147662522843167 GO:0051879 Hsp90 protein binding 4/476 42/18639 0.0952380952380952 3.72929171668667 0.0218759293100988 0.147662522843167 GO:0005507 copper ion binding 5/476 63/18639 0.0793650793650794 3.1077430972389 0.0222470128623422 0.148789654831628 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/476 24/18639 0.125 4.89469537815126 0.0224950548208839 0.149080863312949 GO:0016922 nuclear receptor binding 8/476 137/18639 0.0583941605839416 2.28657302336993 0.0244890414510235 0.152788688455295 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/476 25/18639 0.12 4.69890756302521 0.0250893366360988 0.152788688455295 GO:0120013 lipid transfer activity 5/476 65/18639 0.0769230769230769 3.01212023270847 0.0250949145622949 0.152788688455295 GO:0005528 FK506 binding 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:0070513 death domain binding 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:0097177 mitochondrial ribosome binding 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/476 10/18639 0.2 7.83151260504202 0.0255695747483483 0.152788688455295 GO:0120014 phospholipid transfer activity 3/476 26/18639 0.115384615384615 4.5181803490627 0.0278375524723448 0.163999644278147 GO:0016874 ligase activity 9/476 167/18639 0.0538922155688623 2.11028782770593 0.0278956870925793 0.163999644278147 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/476 67/18639 0.0746268656716418 2.9222061959112 0.0281666295637578 0.164267783615836 GO:0043178 alcohol binding 6/476 92/18639 0.0652173913043478 2.55375411033979 0.0304158297050464 0.17101392109283 GO:0019107 myristoyltransferase activity 2/476 11/18639 0.181818181818182 7.11955691367456 0.030730896657285 0.17101392109283 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/476 11/18639 0.181818181818182 7.11955691367456 0.030730896657285 0.17101392109283 GO:0070990 snRNP binding 2/476 11/18639 0.181818181818182 7.11955691367456 0.030730896657285 0.17101392109283 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/476 11/18639 0.181818181818182 7.11955691367456 0.030730896657285 0.17101392109283 GO:1990948 ubiquitin ligase inhibitor activity 2/476 11/18639 0.181818181818182 7.11955691367456 0.030730896657285 0.17101392109283 GO:0061134 peptidase regulator activity 11/476 226/18639 0.0486725663716814 1.90589908529784 0.0311088659107735 0.171805782189045 GO:0002039 p53 binding 5/476 69/18639 0.072463768115942 2.83750456704421 0.0314667983698305 0.172475909861703 GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/476 48/18639 0.0833333333333333 3.26313025210084 0.0337859621059587 0.182483226907072 GO:0046625 sphingolipid binding 3/476 28/18639 0.107142857142857 4.19545318127251 0.0337931901679763 0.182483226907072 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 15/476 349/18639 0.0429799426934097 1.68298981483711 0.0352684685754569 0.186171633553799 GO:0004859 phospholipase inhibitor activity 2/476 12/18639 0.166666666666667 6.52626050420168 0.036263884725157 0.186171633553799 GO:0005527 macrolide binding 2/476 12/18639 0.166666666666667 6.52626050420168 0.036263884725157 0.186171633553799 GO:0016208 AMP binding 2/476 12/18639 0.166666666666667 6.52626050420168 0.036263884725157 0.186171633553799 GO:0035259 nuclear glucocorticoid receptor binding 2/476 12/18639 0.166666666666667 6.52626050420168 0.036263884725157 0.186171633553799 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/476 12/18639 0.166666666666667 6.52626050420168 0.036263884725157 0.186171633553799 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/476 12/18639 0.166666666666667 6.52626050420168 0.036263884725157 0.186171633553799 GO:0043539 protein serine/threonine kinase activator activity 5/476 73/18639 0.0684931506849315 2.68202486474042 0.0387676456703342 0.197633662193522 GO:0031210 phosphatidylcholine binding 3/476 30/18639 0.1 3.91575630252101 0.0403539231559146 0.204271781173292 GO:0048029 monosaccharide binding 5/476 74/18639 0.0675675675675676 2.64578128548717 0.0407409953552632 0.204271781173292 GO:0016830 carbon-carbon lyase activity 4/476 51/18639 0.0784313725490196 3.07118141374197 0.0409103978755838 0.204271781173292 GO:0005542 folic acid binding 2/476 13/18639 0.153846153846154 6.02424046541694 0.0421462743587434 0.209011115697442 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/476 32/18639 0.09375 3.67102153361345 0.0475075956812665 0.234007008457049 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/476 14/18639 0.142857142857143 5.59393757503001 0.0483566915899221 0.234166580442686 GO:1990825 sequence-specific mRNA binding 2/476 14/18639 0.142857142857143 5.59393757503001 0.0483566915899221 0.234166580442686 GO:0004722 protein serine/threonine phosphatase activity 6/476 103/18639 0.058252427184466 2.28102308884719 0.0485036401191298 0.234166580442686 GO:0098632 cell-cell adhesion mediator activity 4/476 55/18639 0.0727272727272727 2.84782276546982 0.0516326958603519 0.247633126856556 GO:0000774 adenyl-nucleotide exchange factor activity 2/476 15/18639 0.133333333333333 5.22100840336134 0.0548746222632674 0.256433330961038 GO:0004129 cytochrome-c oxidase activity 2/476 15/18639 0.133333333333333 5.22100840336134 0.0548746222632674 0.256433330961038 GO:0141050 histone H3K deacetylase activity 2/476 15/18639 0.133333333333333 5.22100840336134 0.0548746222632674 0.256433330961038 GO:0141051 histone H4K deacetylase activity 2/476 15/18639 0.133333333333333 5.22100840336134 0.0548746222632674 0.256433330961038 GO:0001618 virus receptor activity 5/476 81/18639 0.0617283950617284 2.4171335200747 0.0562390904779739 0.261135649416834 GO:0140272 exogenous protein binding 5/476 82/18639 0.0609756097560976 2.387656282025 0.0586948679415474 0.270813662844228 GO:0016229 steroid dehydrogenase activity 3/476 35/18639 0.0857142857142857 3.35636254501801 0.0593147719099549 0.271952633473944 GO:0000062 fatty-acyl-CoA binding 2/476 16/18639 0.125 4.89469537815126 0.0616803822113308 0.272515143224607 GO:0003688 DNA replication origin binding 2/476 16/18639 0.125 4.89469537815126 0.0616803822113308 0.272515143224607 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/476 16/18639 0.125 4.89469537815126 0.0616803822113308 0.272515143224607 GO:0017070 U6 snRNA binding 2/476 16/18639 0.125 4.89469537815126 0.0616803822113308 0.272515143224607 GO:0043023 ribosomal large subunit binding 2/476 16/18639 0.125 4.89469537815126 0.0616803822113308 0.272515143224607 GO:0055102 lipase inhibitor activity 2/476 16/18639 0.125 4.89469537815126 0.0616803822113308 0.272515143224607 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/476 36/18639 0.0833333333333333 3.26313025210084 0.0635281284864744 0.278987985943613 GO:0003713 transcription coactivator activity 11/476 256/18639 0.04296875 1.6825515362395 0.065074354034463 0.284067090366009 GO:0019213 deacetylase activity 3/476 37/18639 0.0810810810810811 3.1749375425846 0.0678758990395519 0.29140964787457 GO:0022829 wide pore channel activity 3/476 37/18639 0.0810810810810811 3.1749375425846 0.0678758990395519 0.29140964787457 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/476 17/18639 0.117647058823529 4.60677212061295 0.0687550883874157 0.29140964787457 GO:0048038 quinone binding 2/476 17/18639 0.117647058823529 4.60677212061295 0.0687550883874157 0.29140964787457 GO:1901567 fatty acid derivative binding 2/476 17/18639 0.117647058823529 4.60677212061295 0.0687550883874157 0.29140964787457 GO:0000287 magnesium ion binding 10/476 230/18639 0.0434782608695652 1.70250274022653 0.0716585206323918 0.301959893300657 GO:0020037 heme binding 7/476 142/18639 0.0492957746478873 1.9303024026512 0.0721298954082164 0.3021993893827 GO:0003746 translation elongation factor activity 2/476 18/18639 0.111111111111111 4.35084033613445 0.0760806309265528 0.308126555252539 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/476 18/18639 0.111111111111111 4.35084033613445 0.0760806309265528 0.308126555252539 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/476 18/18639 0.111111111111111 4.35084033613445 0.0760806309265528 0.308126555252539 GO:0070064 proline-rich region binding 2/476 18/18639 0.111111111111111 4.35084033613445 0.0760806309265528 0.308126555252539 GO:0098641 cadherin binding involved in cell-cell adhesion 2/476 18/18639 0.111111111111111 4.35084033613445 0.0760806309265528 0.308126555252539 GO:1990381 ubiquitin-specific protease binding 2/476 18/18639 0.111111111111111 4.35084033613445 0.0760806309265528 0.308126555252539 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/476 39/18639 0.0769230769230769 3.01212023270847 0.0769632092709342 0.309978892588459 GO:0003727 single-stranded RNA binding 5/476 89/18639 0.0561797752808989 2.19986309130394 0.0775680116123471 0.31069824431539 GO:0061791 GTPase motor activity 3/476 40/18639 0.075 2.93681722689076 0.0816967386237836 0.323678926395317 GO:1990606 membrane scission GTPase motor activity 3/476 40/18639 0.075 2.93681722689076 0.0816967386237836 0.323678926395317 GO:0120227 acyl-CoA binding 2/476 19/18639 0.105263157894737 4.1218487394958 0.0836396461062488 0.329585416278137 GO:0019209 kinase activator activity 7/476 148/18639 0.0472972972972973 1.85204689984102 0.0855161724916498 0.335168224443079 GO:0140097 catalytic activity, acting on DNA 13/476 336/18639 0.0386904761904762 1.51502475990396 0.0911778509167655 0.349339165131644 GO:0016408 C-acyltransferase activity 2/476 20/18639 0.1 3.91575630252101 0.0914154901794213 0.349339165131644 GO:0030742 GTP-dependent protein binding 2/476 20/18639 0.1 3.91575630252101 0.0914154901794213 0.349339165131644 GO:0061608 nuclear import signal receptor activity 2/476 20/18639 0.1 3.91575630252101 0.0914154901794213 0.349339165131644 GO:0004520 DNA endonuclease activity 3/476 42/18639 0.0714285714285714 2.79696878751501 0.0915278196709794 0.349339165131644 GO:0005539 glycosaminoglycan binding 10/476 242/18639 0.0413223140495868 1.61808111674422 0.0927624224942188 0.352207322907737 GO:0046906 tetrapyrrole binding 7/476 152/18639 0.0460526315789474 1.80330882352941 0.0951760443960511 0.357538774886949 GO:0005548 phospholipid transporter activity 4/476 68/18639 0.0588235294117647 2.30338606030648 0.0958449643125565 0.357538774886949 GO:1990841 promoter-specific chromatin binding 4/476 68/18639 0.0588235294117647 2.30338606030648 0.0958449643125565 0.357538774886949 GO:0008200 ion channel inhibitor activity 3/476 43/18639 0.0697674418604651 2.73192300175884 0.0966188458885171 0.357538774886949 GO:0048156 tau protein binding 3/476 43/18639 0.0697674418604651 2.73192300175884 0.0966188458885171 0.357538774886949 GO:0070182 DNA polymerase binding 2/476 21/18639 0.0952380952380952 3.72929171668667 0.0993922140527546 0.365944060830597 GO:0061135 endopeptidase regulator activity 8/476 184/18639 0.0434782608695652 1.70250274022653 0.100099583208191 0.366696463109403 GO:0016248 channel inhibitor activity 3/476 44/18639 0.0681818181818182 2.66983384262796 0.101822404915161 0.369296184990809 GO:0030547 signaling receptor inhibitor activity 3/476 44/18639 0.0681818181818182 2.66983384262796 0.101822404915161 0.369296184990809 GO:0140104 molecular carrier activity 10/476 249/18639 0.0401606425702811 1.57259289257872 0.106617670816859 0.380617761038355 GO:0141110 transporter inhibitor activity 3/476 45/18639 0.0666666666666667 2.61050420168067 0.10713508683677 0.380617761038355 GO:0004407 histone deacetylase activity 2/476 22/18639 0.0909090909090909 3.55977845683728 0.107554538784501 0.380617761038355 GO:0033558 protein lysine deacetylase activity 2/476 22/18639 0.0909090909090909 3.55977845683728 0.107554538784501 0.380617761038355 GO:0070034 telomerase RNA binding 2/476 22/18639 0.0909090909090909 3.55977845683728 0.107554538784501 0.380617761038355 GO:0031490 chromatin DNA binding 6/476 128/18639 0.046875 1.83551076680672 0.110028637842325 0.387248714693617 GO:0051020 GTPase binding 12/476 315/18639 0.0380952380952381 1.49171668667467 0.110490716949619 0.387248714693617 GO:0140102 catalytic activity, acting on a rRNA 2/476 23/18639 0.0869565217391304 3.40500548045305 0.115887831876522 0.403215612835091 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6/476 130/18639 0.0461538461538462 1.80727213962508 0.11615264567266 0.403215612835091 GO:0005504 fatty acid binding 3/476 47/18639 0.0638297872340425 2.49941891650277 0.118073972692383 0.406018519305412 GO:0043495 protein-membrane adaptor activity 3/476 47/18639 0.0638297872340425 2.49941891650277 0.118073972692383 0.406018519305412 GO:0003684 damaged DNA binding 4/476 74/18639 0.0540540540540541 2.11662502838973 0.12071158859781 0.411209103214035 GO:0031491 nucleosome binding 4/476 74/18639 0.0540540540540541 2.11662502838973 0.12071158859781 0.411209103214035 GO:0044389 ubiquitin-like protein ligase binding 12/476 322/18639 0.0372670807453416 1.45928806305131 0.123984359619874 0.420393479827388 GO:0022804 active transmembrane transporter activity 16/476 457/18639 0.0350109409190372 1.37094312560911 0.127131329238285 0.42906823617921 GO:0016763 pentosyltransferase activity 3/476 49/18639 0.0612244897959184 2.39740181787 0.129407505207337 0.432743446312607 GO:0060590 ATPase regulator activity 3/476 49/18639 0.0612244897959184 2.39740181787 0.129407505207337 0.432743446312607 GO:0120020 cholesterol transfer activity 2/476 25/18639 0.08 3.13260504201681 0.133011888483955 0.442765601391794 GO:0044325 transmembrane transporter binding 6/476 136/18639 0.0441176470588235 1.72753954522986 0.135516907172557 0.447021834066942 GO:0140789 histone phosphatase activity 6/476 136/18639 0.0441176470588235 1.72753954522986 0.135516907172557 0.447021834066942 GO:0016247 channel regulator activity 7/476 168/18639 0.0416666666666667 1.63156512605042 0.13948963319893 0.458053795504595 GO:0030544 Hsp70 protein binding 3/476 51/18639 0.0588235294117647 2.30338606030648 0.141107357652346 0.461288178154979 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/476 26/18639 0.0769230769230769 3.01212023270847 0.141776416484922 0.461406284006733 GO:0141108 transporter regulator activity 7/476 170/18639 0.0411764705882353 1.61237024221453 0.145635837694277 0.470092790778729 GO:0030295 protein kinase activator activity 6/476 139/18639 0.0431654676258993 1.69025451907382 0.145735213602185 0.470092790778729 GO:0048306 calcium-dependent protein binding 4/476 80/18639 0.05 1.9578781512605 0.148026663689227 0.475380783389631 GO:0008266 poly(U) RNA binding 2/476 27/18639 0.0740740740740741 2.90056022408964 0.150659399579852 0.477524792581357 GO:0015252 proton channel activity 2/476 27/18639 0.0740740740740741 2.90056022408964 0.150659399579852 0.477524792581357 GO:0023026 MHC class II protein complex binding 2/476 27/18639 0.0740740740740741 2.90056022408964 0.150659399579852 0.477524792581357 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/476 53/18639 0.0566037735849057 2.21646583161567 0.153145082214317 0.483302012702326 GO:1902936 phosphatidylinositol bisphosphate binding 5/476 111/18639 0.045045045045045 1.76385419032478 0.154799875690297 0.48641857490615 GO:0019789 SUMO transferase activity 2/476 28/18639 0.0714285714285714 2.79696878751501 0.15964910799615 0.493153388683023 GO:0046966 nuclear thyroid hormone receptor binding 2/476 28/18639 0.0714285714285714 2.79696878751501 0.15964910799615 0.493153388683023 GO:0051019 mitogen-activated protein kinase binding 2/476 28/18639 0.0714285714285714 2.79696878751501 0.15964910799615 0.493153388683023 GO:0097718 disordered domain specific binding 2/476 28/18639 0.0714285714285714 2.79696878751501 0.15964910799615 0.493153388683023 GO:0140313 molecular sequestering activity 3/476 55/18639 0.0545454545454545 2.13586707410237 0.165492292261758 0.506202994549463 GO:0004860 protein kinase inhibitor activity 4/476 84/18639 0.0476190476190476 1.86464585834334 0.167437701496503 0.506202994549463 GO:0051117 ATPase binding 4/476 84/18639 0.0476190476190476 1.86464585834334 0.167437701496503 0.506202994549463 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/476 29/18639 0.0689655172413793 2.70052158794552 0.168734331516488 0.506202994549463 GO:0043236 laminin binding 2/476 29/18639 0.0689655172413793 2.70052158794552 0.168734331516488 0.506202994549463 GO:0097472 cyclin-dependent protein kinase activity 2/476 29/18639 0.0689655172413793 2.70052158794552 0.168734331516488 0.506202994549463 GO:0106222 lncRNA binding 2/476 29/18639 0.0689655172413793 2.70052158794552 0.168734331516488 0.506202994549463 GO:0005525 GTP binding 13/476 378/18639 0.0343915343915344 1.34668867547019 0.171947272621487 0.51372771205354 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/476 86/18639 0.0465116279069767 1.82128200117256 0.17746530283377 0.525069955220397 GO:0008187 poly-pyrimidine tract binding 2/476 30/18639 0.0666666666666667 2.61050420168067 0.1779043606851 0.525069955220397 GO:0016769 transferase activity, transferring nitrogenous groups 2/476 30/18639 0.0666666666666667 2.61050420168067 0.1779043606851 0.525069955220397 GO:0016887 ATP hydrolysis activity 14/476 417/18639 0.0335731414868106 1.31464240372408 0.18234000734777 0.53599139256663 GO:0016741 transferase activity, transferring one-carbon groups 8/476 215/18639 0.0372093023255814 1.45702560093805 0.185832896041074 0.541395230685169 GO:0005164 tumor necrosis factor receptor binding 2/476 31/18639 0.0645161290322581 2.52629438872323 0.18714896863191 0.541395230685169 GO:0008327 methyl-CpG binding 2/476 31/18639 0.0645161290322581 2.52629438872323 0.18714896863191 0.541395230685169 GO:0016878 acid-thiol ligase activity 2/476 31/18639 0.0645161290322581 2.52629438872323 0.18714896863191 0.541395230685169 GO:0030515 snoRNA binding 2/476 32/18639 0.0625 2.44734768907563 0.196458393495287 0.559445972101812 GO:0031369 translation initiation factor binding 2/476 32/18639 0.0625 2.44734768907563 0.196458393495287 0.559445972101812 GO:0120015 sterol transfer activity 2/476 32/18639 0.0625 2.44734768907563 0.196458393495287 0.559445972101812 GO:0140142 nucleocytoplasmic carrier activity 2/476 32/18639 0.0625 2.44734768907563 0.196458393495287 0.559445972101812 GO:0019210 kinase inhibitor activity 4/476 90/18639 0.0444444444444444 1.74033613445378 0.19809887131943 0.561922479345777 GO:0003712 transcription coregulator activity 16/476 495/18639 0.0323232323232323 1.26569900687548 0.200314844831215 0.563408730023171 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 5/476 122/18639 0.040983606557377 1.6048181567709 0.20198392005098 0.563408730023171 GO:0031406 carboxylic acid binding 7/476 187/18639 0.0374331550802139 1.46579112928594 0.202687233915654 0.563408730023171 GO:0072341 modified amino acid binding 4/476 91/18639 0.043956043956044 1.7212115615477 0.203368047618059 0.563408730023171 GO:0140311 protein sequestering activity 2/476 33/18639 0.0606060606060606 2.37318563789152 0.205823321424809 0.563408730023171 GO:0140597 protein carrier chaperone 7/476 188/18639 0.0372340425531915 1.45799436795995 0.206286253369711 0.563408730023171 GO:0043177 organic acid binding 7/476 189/18639 0.037037037037037 1.45028011204482 0.209909423605189 0.563408730023171 GO:0051213 dioxygenase activity 4/476 93/18639 0.043010752688172 1.68419625914882 0.214027646683858 0.563408730023171 GO:0016831 carboxy-lyase activity 2/476 34/18639 0.0588235294117647 2.30338606030648 0.215234870145983 0.563408730023171 GO:0004536 DNA nuclease activity 3/476 64/18639 0.046875 1.83551076680672 0.224139197835031 0.563408730023171 GO:0034061 DNA polymerase activity 2/476 35/18639 0.0571428571428571 2.237575030012 0.224684573069379 0.563408730023171 GO:0061631 ubiquitin conjugating enzyme activity 2/476 35/18639 0.0571428571428571 2.237575030012 0.224684573069379 0.563408730023171 GO:0004867 serine-type endopeptidase inhibitor activity 4/476 95/18639 0.0421052631578947 1.64873949579832 0.2248377774391 0.563408730023171 GO:0008276 protein methyltransferase activity 4/476 95/18639 0.0421052631578947 1.64873949579832 0.2248377774391 0.563408730023171 GO:0004519 endonuclease activity 5/476 127/18639 0.0393700787401575 1.5416363395752 0.22487055454333 0.563408730023171 GO:0019001 guanyl nucleotide binding 13/476 400/18639 0.0325 1.27262079831933 0.225002308182866 0.563408730023171 GO:0032561 guanyl ribonucleotide binding 13/476 400/18639 0.0325 1.27262079831933 0.225002308182866 0.563408730023171 GO:0099106 ion channel regulator activity 6/476 160/18639 0.0375 1.46840861344538 0.225899876057366 0.563408730023171 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0004090 carbonyl reductase (NADPH) activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0005345 purine nucleobase transmembrane transporter activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0015203 polyamine transmembrane transporter activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0015643 toxic substance binding 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0016868 intramolecular phosphotransferase activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0019911 structural constituent of myelin sheath 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0030957 Tat protein binding 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0032356 oxidized DNA binding 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0035374 chondroitin sulfate binding 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0042975 peroxisome proliferator activated receptor binding 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0047429 nucleoside triphosphate diphosphatase activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0098505 G-rich strand telomeric DNA binding 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0140940 histone H2A methyltransferase activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:1990259 histone H2AQ104 methyltransferase activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:1990757 ubiquitin ligase activator activity 1/476 10/18639 0.1 3.91575630252101 0.227991187046413 0.563408730023171 GO:0016407 acetyltransferase activity 4/476 96/18639 0.0416666666666667 1.63156512605042 0.230295130623668 0.566754000389135 GO:0160215 deacylase activity 3/476 65/18639 0.0461538461538462 1.80727213962508 0.230899777936314 0.566754000389135 GO:0046982 protein heterodimerization activity 12/476 369/18639 0.032520325203252 1.27341668374667 0.23602126750163 0.569671452764047 GO:0023023 MHC protein complex binding 2/476 37/18639 0.0540540540540541 2.11662502838973 0.243666561920776 0.569671452764047 GO:0050840 extracellular matrix binding 3/476 67/18639 0.0447761194029851 1.75332371754672 0.24452882449442 0.569671452764047 GO:0031625 ubiquitin protein ligase binding 10/476 302/18639 0.033112582781457 1.29660804719239 0.245103475920082 0.569671452764047 GO:0000099 sulfur amino acid transmembrane transporter activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0008172 S-methyltransferase activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0008271 secondary active sulfate transmembrane transporter activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0008432 JUN kinase binding 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0008526 phosphatidylinositol transfer activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0015173 aromatic amino acid transmembrane transporter activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0015205 nucleobase transmembrane transporter activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0015217 ADP transmembrane transporter activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0019206 nucleoside kinase activity 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0034056 estrogen response element binding 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0034713 type I transforming growth factor beta receptor binding 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0042608 T cell receptor binding 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0050998 nitric-oxide synthase binding 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0070697 activin receptor binding 1/476 11/18639 0.0909090909090909 3.55977845683728 0.247717216085326 0.569671452764047 GO:0140223 general transcription initiation factor activity 3/476 68/18639 0.0441176470588235 1.72753954522986 0.251391156502813 0.572351292606897 GO:0042162 telomeric DNA binding 2/476 38/18639 0.0526315789473684 2.0609243697479 0.253183857363055 0.572351292606897 GO:0008080 N-acetyltransferase activity 3/476 69/18639 0.0434782608695652 1.70250274022653 0.258281359180153 0.572351292606897 GO:0030414 peptidase inhibitor activity 6/476 169/18639 0.0355029585798817 1.39020933817314 0.263942764325264 0.572351292606897 GO:0000340 RNA 7-methylguanosine cap binding 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0003720 telomerase activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0003995 acyl-CoA dehydrogenase activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0005078 MAP-kinase scaffold activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0008504 monoamine transmembrane transporter activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0015368 calcium:monoatomic cation antiporter activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0016273 arginine N-methyltransferase activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0016274 protein-arginine N-methyltransferase activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0016801 hydrolase activity, acting on ether bonds 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0016803 ether hydrolase activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0016840 carbon-nitrogen lyase activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0036009 protein-glutamine N-methyltransferase activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0042301 phosphate ion binding 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0043047 single-stranded telomeric DNA binding 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0097371 MDM2/MDM4 family protein binding 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:1990459 transferrin receptor binding 1/476 12/18639 0.0833333333333333 3.26313025210084 0.266940246208978 0.572351292606897 GO:0002020 protease binding 5/476 136/18639 0.0367647058823529 1.43961628769155 0.267807349049169 0.572526561457022 GO:0030331 nuclear estrogen receptor binding 2/476 40/18639 0.05 1.9578781512605 0.27223627459924 0.578601294993719 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/476 40/18639 0.05 1.9578781512605 0.27223627459924 0.578601294993719 GO:0008201 heparin binding 6/476 172/18639 0.0348837209302326 1.36596150087942 0.276979991903022 0.585786409630875 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/476 41/18639 0.0487804878048781 1.91012502562 0.281758509981498 0.585786409630875 GO:0017080 sodium channel regulator activity 2/476 41/18639 0.0487804878048781 1.91012502562 0.281758509981498 0.585786409630875 GO:0140767 enzyme-substrate adaptor activity 5/476 139/18639 0.0359712230215827 1.40854543256151 0.282513122737289 0.585786409630875 GO:0003964 RNA-directed DNA polymerase activity 1/476 13/18639 0.0769230769230769 3.01212023270847 0.285673077196498 0.585786409630875 GO:0005172 vascular endothelial growth factor receptor binding 1/476 13/18639 0.0769230769230769 3.01212023270847 0.285673077196498 0.585786409630875 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/476 13/18639 0.0769230769230769 3.01212023270847 0.285673077196498 0.585786409630875 GO:0030955 potassium ion binding 1/476 13/18639 0.0769230769230769 3.01212023270847 0.285673077196498 0.585786409630875 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/476 13/18639 0.0769230769230769 3.01212023270847 0.285673077196498 0.585786409630875 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/476 13/18639 0.0769230769230769 3.01212023270847 0.285673077196498 0.585786409630875 GO:0071837 HMG box domain binding 1/476 13/18639 0.0769230769230769 3.01212023270847 0.285673077196498 0.585786409630875 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/476 13/18639 0.0769230769230769 3.01212023270847 0.285673077196498 0.585786409630875 GO:0004521 RNA endonuclease activity 3/476 73/18639 0.0410958904109589 1.60921491884425 0.286063047775846 0.585786409630875 GO:0004721 phosphoprotein phosphatase activity 6/476 175/18639 0.0342857142857143 1.3425450180072 0.2901635820525 0.592518911250063 GO:0004402 histone acetyltransferase activity 2/476 42/18639 0.0476190476190476 1.86464585834334 0.291270044497024 0.593116934185281 GO:0008375 acetylglucosaminyltransferase activity 2/476 43/18639 0.0465116279069767 1.82128200117256 0.300765224916951 0.602075124936957 GO:0005319 lipid transporter activity 6/476 178/18639 0.0337078651685393 1.31991785478236 0.303474501956943 0.602075124936957 GO:0005347 ATP transmembrane transporter activity 1/476 14/18639 0.0714285714285714 2.79696878751501 0.303928183781619 0.602075124936957 GO:0016530 metallochaperone activity 1/476 14/18639 0.0714285714285714 2.79696878751501 0.303928183781619 0.602075124936957 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/476 14/18639 0.0714285714285714 2.79696878751501 0.303928183781619 0.602075124936957 GO:0043176 amine binding 1/476 14/18639 0.0714285714285714 2.79696878751501 0.303928183781619 0.602075124936957 GO:0044548 S100 protein binding 1/476 14/18639 0.0714285714285714 2.79696878751501 0.303928183781619 0.602075124936957 GO:0070742 C2H2 zinc finger domain binding 1/476 14/18639 0.0714285714285714 2.79696878751501 0.303928183781619 0.602075124936957 GO:0098847 sequence-specific single stranded DNA binding 1/476 14/18639 0.0714285714285714 2.79696878751501 0.303928183781619 0.602075124936957 GO:1901612 cardiolipin binding 1/476 14/18639 0.0714285714285714 2.79696878751501 0.303928183781619 0.602075124936957 GO:0001046 core promoter sequence-specific DNA binding 2/476 44/18639 0.0454545454545455 1.77988922841864 0.310238692536084 0.611254072591366 GO:0043014 alpha-tubulin binding 2/476 44/18639 0.0454545454545455 1.77988922841864 0.310238692536084 0.611254072591366 GO:0051539 4 iron, 4 sulfur cluster binding 2/476 45/18639 0.0444444444444444 1.74033613445378 0.319685371870936 0.6155701331125 GO:0004089 carbonate dehydratase activity 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0010181 FMN binding 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0015116 sulfate transmembrane transporter activity 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0016846 carbon-sulfur lyase activity 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0031386 protein tag activity 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0033130 acetylcholine receptor binding 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0048531 beta-1,3-galactosyltransferase activity 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0140776 protein-containing complex destabilizing activity 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0141047 molecular tag activity 1/476 15/18639 0.0666666666666667 2.61050420168067 0.321717723890072 0.6155701331125 GO:0033293 monocarboxylic acid binding 3/476 79/18639 0.0379746835443038 1.48699606424848 0.32809913422069 0.621009823974789 GO:1901981 phosphatidylinositol phosphate binding 6/476 185/18639 0.0324324324324324 1.26997501703384 0.334922651834638 0.621009823974789 GO:0001221 transcription coregulator binding 4/476 115/18639 0.0347826086956522 1.36200219218122 0.338363826273127 0.621009823974789 GO:0061733 protein-lysine-acetyltransferase activity 2/476 47/18639 0.0425531914893617 1.66627927766851 0.338479414720907 0.621009823974789 GO:0061749 forked DNA-dependent helicase activity 2/476 47/18639 0.0425531914893617 1.66627927766851 0.338479414720907 0.621009823974789 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/476 47/18639 0.0425531914893617 1.66627927766851 0.338479414720907 0.621009823974789 GO:0004708 MAP kinase kinase activity 1/476 16/18639 0.0625 2.44734768907563 0.339053546668655 0.621009823974789 GO:0005159 insulin-like growth factor receptor binding 1/476 16/18639 0.0625 2.44734768907563 0.339053546668655 0.621009823974789 GO:0008296 3'-5'-DNA exonuclease activity 1/476 16/18639 0.0625 2.44734768907563 0.339053546668655 0.621009823974789 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/476 16/18639 0.0625 2.44734768907563 0.339053546668655 0.621009823974789 GO:0070411 I-SMAD binding 1/476 16/18639 0.0625 2.44734768907563 0.339053546668655 0.621009823974789 GO:0097027 ubiquitin-protein transferase activator activity 1/476 16/18639 0.0625 2.44734768907563 0.339053546668655 0.621009823974789 GO:0003924 GTPase activity 10/476 331/18639 0.0302114803625378 1.18300794638097 0.339326781149748 0.621009823974789 GO:0030971 receptor tyrosine kinase binding 3/476 81/18639 0.037037037037037 1.45028011204482 0.342127256124349 0.621009823974789 GO:0000510 H3-H4 histone complex chaperone activity 5/476 151/18639 0.033112582781457 1.29660804719239 0.34258372524316 0.621009823974789 GO:0140584 chromatin extrusion motor activity 5/476 151/18639 0.033112582781457 1.29660804719239 0.34258372524316 0.621009823974789 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 5/476 151/18639 0.033112582781457 1.29660804719239 0.34258372524316 0.621009823974789 GO:0140849 ATP-dependent H2AZ histone chaperone activity 5/476 151/18639 0.033112582781457 1.29660804719239 0.34258372524316 0.621009823974789 GO:0015616 DNA translocase activity 5/476 152/18639 0.0328947368421053 1.28807773109244 0.347646236484858 0.621009823974789 GO:0140674 ATP-dependent histone chaperone activity 5/476 152/18639 0.0328947368421053 1.28807773109244 0.347646236484858 0.621009823974789 GO:0009378 four-way junction helicase activity 2/476 48/18639 0.0416666666666667 1.63156512605042 0.347817946952332 0.621009823974789 GO:0036121 double-stranded DNA helicase activity 2/476 48/18639 0.0416666666666667 1.63156512605042 0.347817946952332 0.621009823974789 GO:0043138 3'-5' DNA helicase activity 2/476 48/18639 0.0416666666666667 1.63156512605042 0.347817946952332 0.621009823974789 GO:0061775 cohesin loader activity 5/476 153/18639 0.0326797385620915 1.27965892239249 0.352713106990147 0.621009823974789 GO:0004549 tRNA-specific ribonuclease activity 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0005092 GDP-dissociation inhibitor activity 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0008429 phosphatidylethanolamine binding 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0016805 dipeptidase activity 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0030548 acetylcholine receptor regulator activity 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0032977 membrane insertase activity 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0036041 long-chain fatty acid binding 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0046965 nuclear retinoid X receptor binding 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0051787 misfolded protein binding 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0070402 NADPH binding 1/476 17/18639 0.0588235294117647 2.30338606030648 0.355947200311233 0.621009823974789 GO:0001540 amyloid-beta binding 3/476 83/18639 0.036144578313253 1.41533360332085 0.356132537047025 0.621009823974789 GO:0001222 transcription corepressor binding 2/476 49/18639 0.0408163265306122 1.59826787858 0.357112008303182 0.621009823974789 GO:0005506 iron ion binding 5/476 154/18639 0.0324675324675325 1.27134944887046 0.357783437680948 0.621009823974789 GO:0032813 tumor necrosis factor receptor superfamily binding 2/476 50/18639 0.04 1.5663025210084 0.366357782864067 0.622632858372419 GO:0032182 ubiquitin-like protein binding 4/476 120/18639 0.0333333333333333 1.30525210084034 0.367428710537055 0.622632858372419 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 7/476 229/18639 0.0305676855895196 1.19695607500642 0.368818666467051 0.622632858372419 GO:0000900 mRNA regulatory element binding translation repressor activity 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0008525 phosphatidylcholine transporter activity 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0016854 racemase and epimerase activity 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0017128 phospholipid scramblase activity 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0031690 adrenergic receptor binding 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0035615 clathrin adaptor activity 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0050811 GABA receptor binding 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0070628 proteasome binding 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0099602 neurotransmitter receptor regulator activity 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:1901611 phosphatidylglycerol binding 1/476 18/18639 0.0555555555555556 2.17542016806723 0.372409939686802 0.622632858372419 GO:0003697 single-stranded DNA binding 4/476 121/18639 0.0330578512396694 1.29446489339537 0.373238078338473 0.622632858372419 GO:0004540 RNA nuclease activity 4/476 121/18639 0.0330578512396694 1.29446489339537 0.373238078338473 0.622632858372419 GO:0140658 ATP-dependent chromatin remodeler activity 5/476 158/18639 0.0316455696202532 1.23916338687374 0.378081734262634 0.629273023464522 GO:0003689 DNA clamp loader activity 5/476 160/18639 0.03125 1.22367384453782 0.388229022577342 0.637797393967772 GO:0003756 protein disulfide isomerase activity 1/476 19/18639 0.0526315789473684 2.0609243697479 0.38845273377461 0.637797393967772 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/476 19/18639 0.0526315789473684 2.0609243697479 0.38845273377461 0.637797393967772 GO:0008301 DNA binding, bending 1/476 19/18639 0.0526315789473684 2.0609243697479 0.38845273377461 0.637797393967772 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/476 19/18639 0.0526315789473684 2.0609243697479 0.38845273377461 0.637797393967772 GO:0031420 alkali metal ion binding 1/476 19/18639 0.0526315789473684 2.0609243697479 0.38845273377461 0.637797393967772 GO:0005543 phospholipid binding 14/476 497/18639 0.028169014084507 1.10302994437211 0.392215359781656 0.639328972678159 GO:0004866 endopeptidase inhibitor activity 5/476 161/18639 0.031055900621118 1.21607338587609 0.393299267371037 0.639328972678159 GO:0004864 protein phosphatase inhibitor activity 2/476 53/18639 0.0377358490566038 1.47764388774378 0.393770519523311 0.639328972678159 GO:0005544 calcium-dependent phospholipid binding 2/476 53/18639 0.0377358490566038 1.47764388774378 0.393770519523311 0.639328972678159 GO:0034212 protein N-acetyltransferase activity 2/476 53/18639 0.0377358490566038 1.47764388774378 0.393770519523311 0.639328972678159 GO:0016791 phosphatase activity 8/476 273/18639 0.0293040293040293 1.14747437436513 0.396963714121691 0.641784080506022 GO:0000339 RNA cap binding 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0001614 purinergic nucleotide receptor activity 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0015095 magnesium ion transmembrane transporter activity 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0016502 nucleotide receptor activity 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0016505 peptidase activator activity involved in apoptotic process 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0031418 L-ascorbic acid binding 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0140939 histone H4 methyltransferase activity 1/476 20/18639 0.05 1.9578781512605 0.404086272911199 0.641784080506022 GO:0140713 histone chaperone activity 5/476 164/18639 0.0304878048780488 1.1938281410125 0.408486685586519 0.647362595201244 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/476 21/18639 0.0476190476190476 1.86464585834334 0.419320975854122 0.657387078274526 GO:0001846 opsonin binding 1/476 21/18639 0.0476190476190476 1.86464585834334 0.419320975854122 0.657387078274526 GO:0009975 cyclase activity 1/476 21/18639 0.0476190476190476 1.86464585834334 0.419320975854122 0.657387078274526 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/476 21/18639 0.0476190476190476 1.86464585834334 0.419320975854122 0.657387078274526 GO:0140312 cargo adaptor activity 1/476 21/18639 0.0476190476190476 1.86464585834334 0.419320975854122 0.657387078274526 GO:0019212 phosphatase inhibitor activity 2/476 56/18639 0.0357142857142857 1.3984843937575 0.420631729115383 0.657866746315033 GO:0008168 methyltransferase activity 6/476 204/18639 0.0294117647058824 1.15169303015324 0.421431783990563 0.657866746315033 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5/476 167/18639 0.029940119760479 1.1723821265033 0.423622681643951 0.65987379256077 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/476 130/18639 0.0307692307692308 1.20484809308339 0.425195244965989 0.660911159019629 GO:0016410 N-acyltransferase activity 3/476 94/18639 0.0319148936170213 1.24970945825139 0.432037209637296 0.66517119634337 GO:0008649 rRNA methyltransferase activity 1/476 22/18639 0.0454545454545455 1.77988922841864 0.434166996666961 0.66517119634337 GO:0034062 5'-3' RNA polymerase activity 1/476 22/18639 0.0454545454545455 1.77988922841864 0.434166996666961 0.66517119634337 GO:0097747 RNA polymerase activity 1/476 22/18639 0.0454545454545455 1.77988922841864 0.434166996666961 0.66517119634337 GO:0140035 ubiquitin-like protein reader activity 1/476 22/18639 0.0454545454545455 1.77988922841864 0.434166996666961 0.66517119634337 GO:0031267 small GTPase binding 8/476 283/18639 0.0282685512367491 1.10692757668438 0.435761819382356 0.66517119634337 GO:0008408 3'-5' exonuclease activity 2/476 58/18639 0.0344827586206897 1.35026079397276 0.438197394473072 0.66517119634337 GO:0017116 single-stranded DNA helicase activity 2/476 58/18639 0.0344827586206897 1.35026079397276 0.438197394473072 0.66517119634337 GO:0035091 phosphatidylinositol binding 8/476 284/18639 0.028169014084507 1.10302994437211 0.439630923924999 0.66517119634337 GO:0004518 nuclease activity 6/476 209/18639 0.0287081339712919 1.12414056531704 0.444088921731776 0.66517119634337 GO:0001786 phosphatidylserine binding 2/476 59/18639 0.0338983050847458 1.32737501780373 0.446870886780879 0.66517119634337 GO:0004879 nuclear receptor activity 2/476 59/18639 0.0338983050847458 1.32737501780373 0.446870886780879 0.66517119634337 GO:0015459 potassium channel regulator activity 2/476 59/18639 0.0338983050847458 1.32737501780373 0.446870886780879 0.66517119634337 GO:0031593 polyubiquitin modification-dependent protein binding 2/476 59/18639 0.0338983050847458 1.32737501780373 0.446870886780879 0.66517119634337 GO:0070063 RNA polymerase binding 2/476 59/18639 0.0338983050847458 1.32737501780373 0.446870886780879 0.66517119634337 GO:0000295 adenine nucleotide transmembrane transporter activity 1/476 23/18639 0.0434782608695652 1.70250274022653 0.448634231430162 0.66517119634337 GO:0003887 DNA-directed DNA polymerase activity 1/476 23/18639 0.0434782608695652 1.70250274022653 0.448634231430162 0.66517119634337 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/476 23/18639 0.0434782608695652 1.70250274022653 0.448634231430162 0.66517119634337 GO:0017134 fibroblast growth factor binding 1/476 23/18639 0.0434782608695652 1.70250274022653 0.448634231430162 0.66517119634337 GO:0031681 G-protein beta-subunit binding 1/476 23/18639 0.0434782608695652 1.70250274022653 0.448634231430162 0.66517119634337 GO:0070577 lysine-acetylated histone binding 1/476 23/18639 0.0434782608695652 1.70250274022653 0.448634231430162 0.66517119634337 GO:0140103 catalytic activity, acting on a glycoprotein 1/476 23/18639 0.0434782608695652 1.70250274022653 0.448634231430162 0.66517119634337 GO:0042578 phosphoric ester hydrolase activity 10/476 363/18639 0.0275482093663912 1.07872074449615 0.448922124281122 0.66517119634337 GO:0001098 basal transcription machinery binding 2/476 60/18639 0.0333333333333333 1.30525210084034 0.455468834937763 0.665348845692572 GO:0001099 basal RNA polymerase II transcription machinery binding 2/476 60/18639 0.0333333333333333 1.30525210084034 0.455468834937763 0.665348845692572 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/476 60/18639 0.0333333333333333 1.30525210084034 0.455468834937763 0.665348845692572 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/476 60/18639 0.0333333333333333 1.30525210084034 0.455468834937763 0.665348845692572 GO:0098531 ligand-modulated transcription factor activity 2/476 60/18639 0.0333333333333333 1.30525210084034 0.455468834937763 0.665348845692572 GO:0004725 protein tyrosine phosphatase activity 3/476 98/18639 0.0306122448979592 1.198700908935 0.458873343376846 0.665348845692572 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0005540 hyaluronic acid binding 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0070300 phosphatidic acid binding 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0070840 dynein complex binding 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0140033 acetylation-dependent protein binding 1/476 24/18639 0.0416666666666667 1.63156512605042 0.462732324782077 0.665348845692572 GO:0015026 coreceptor activity 2/476 61/18639 0.0327868852459016 1.28385452541672 0.463989436457815 0.665843108617613 GO:0043130 ubiquitin binding 3/476 100/18639 0.03 1.1747268907563 0.472088486571676 0.666693134392878 GO:0001848 complement binding 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0003707 nuclear steroid receptor activity 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0005537 D-mannose binding 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0008483 transaminase activity 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0015645 fatty acid ligase activity 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0017025 TBP-class protein binding 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0017056 structural constituent of nuclear pore 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0019707 protein-cysteine S-acyltransferase activity 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0042974 nuclear retinoic acid receptor binding 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:0120515 fatty acid-CoA ligase activity 1/476 25/18639 0.04 1.5663025210084 0.476470676294499 0.666693134392878 GO:1901682 sulfur compound transmembrane transporter activity 2/476 63/18639 0.0317460317460317 1.24309723889556 0.480792087920839 0.671451019337723 GO:0004529 DNA exonuclease activity 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0005160 transforming growth factor beta receptor binding 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0008157 protein phosphatase 1 binding 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0008198 ferrous iron binding 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0015216 purine nucleotide transmembrane transporter activity 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0050681 nuclear androgen receptor binding 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0050750 low-density lipoprotein particle receptor binding 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0051139 metal cation:proton antiporter activity 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0097602 cullin family protein binding 1/476 26/18639 0.0384615384615385 1.50606011635423 0.489858446686882 0.672517528502329 GO:0005253 monoatomic anion channel activity 3/476 103/18639 0.029126213592233 1.14051154442359 0.491630466071682 0.673681597304993 GO:0001671 ATPase activator activity 1/476 27/18639 0.037037037037037 1.45028011204482 0.502904563883307 0.68352819927873 GO:0008320 protein transmembrane transporter activity 1/476 27/18639 0.037037037037037 1.45028011204482 0.502904563883307 0.68352819927873 GO:0016405 CoA-ligase activity 1/476 27/18639 0.037037037037037 1.45028011204482 0.502904563883307 0.68352819927873 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/476 27/18639 0.037037037037037 1.45028011204482 0.502904563883307 0.68352819927873 GO:0019903 protein phosphatase binding 4/476 144/18639 0.0277777777777778 1.08771008403361 0.50350431140285 0.68352819927873 GO:0016866 intramolecular transferase activity 1/476 28/18639 0.0357142857142857 1.3984843937575 0.515617728916164 0.697375369907019 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/476 28/18639 0.0357142857142857 1.3984843937575 0.515617728916164 0.697375369907019 GO:0003785 actin monomer binding 1/476 29/18639 0.0344827586206897 1.35026079397276 0.528006421680438 0.707567429053381 GO:0016417 S-acyltransferase activity 1/476 29/18639 0.0344827586206897 1.35026079397276 0.528006421680438 0.707567429053381 GO:0035250 UDP-galactosyltransferase activity 1/476 29/18639 0.0344827586206897 1.35026079397276 0.528006421680438 0.707567429053381 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/476 29/18639 0.0344827586206897 1.35026079397276 0.528006421680438 0.707567429053381 GO:0051861 glycolipid binding 1/476 29/18639 0.0344827586206897 1.35026079397276 0.528006421680438 0.707567429053381 GO:0140098 catalytic activity, acting on RNA 10/476 387/18639 0.0258397932816537 1.01182333398476 0.529969717357704 0.708895273309663 GO:0019842 vitamin binding 4/476 150/18639 0.0266666666666667 1.04420168067227 0.535626842483717 0.711966587467216 GO:0019902 phosphatase binding 5/476 190/18639 0.0263157894736842 1.03046218487395 0.53596481663748 0.711966587467216 GO:0097110 scaffold protein binding 2/476 70/18639 0.0285714285714286 1.118787515006 0.536962010096028 0.711966587467216 GO:0015215 nucleotide transmembrane transporter activity 1/476 30/18639 0.0333333333333333 1.30525210084034 0.540078906542346 0.711966587467216 GO:0031624 ubiquitin conjugating enzyme binding 1/476 30/18639 0.0333333333333333 1.30525210084034 0.540078906542346 0.711966587467216 GO:0033612 receptor serine/threonine kinase binding 1/476 30/18639 0.0333333333333333 1.30525210084034 0.540078906542346 0.711966587467216 GO:0048019 receptor antagonist activity 1/476 30/18639 0.0333333333333333 1.30525210084034 0.540078906542346 0.711966587467216 GO:0051721 protein phosphatase 2A binding 1/476 30/18639 0.0333333333333333 1.30525210084034 0.540078906542346 0.711966587467216 GO:0070325 lipoprotein particle receptor binding 1/476 31/18639 0.032258064516129 1.26314719436162 0.551843237806027 0.726161950109375 GO:0008378 galactosyltransferase activity 1/476 32/18639 0.03125 1.22367384453782 0.563307265041858 0.73858092844517 GO:0022884 macromolecule transmembrane transporter activity 1/476 32/18639 0.03125 1.22367384453782 0.563307265041858 0.73858092844517 GO:0003678 DNA helicase activity 2/476 74/18639 0.027027027027027 1.05831251419487 0.567130393606524 0.742258630052344 GO:0019003 GDP binding 2/476 75/18639 0.0266666666666667 1.04420168067227 0.574447732243731 0.747848084475072 GO:0030296 protein tyrosine kinase activator activity 1/476 33/18639 0.0303030303030303 1.18659281894576 0.574478638279891 0.747848084475072 GO:0140416 transcription regulator inhibitor activity 1/476 33/18639 0.0303030303030303 1.18659281894576 0.574478638279891 0.747848084475072 GO:0030246 carbohydrate binding 7/476 280/18639 0.025 0.978939075630252 0.575907134347664 0.748371302922366 GO:1990782 protein tyrosine kinase binding 3/476 117/18639 0.0256410256410256 1.00404007756949 0.57766714021362 0.749322678319802 GO:0008376 acetylgalactosaminyltransferase activity 1/476 34/18639 0.0294117647058824 1.15169303015324 0.585364813071827 0.755276015450198 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/476 34/18639 0.0294117647058824 1.15169303015324 0.585364813071827 0.755276015450198 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/476 34/18639 0.0294117647058824 1.15169303015324 0.585364813071827 0.755276015450198 GO:0005178 integrin binding 4/476 161/18639 0.0248447204968944 0.972858708700872 0.591659458157089 0.762049019428477 GO:0000175 3'-5'-RNA exonuclease activity 1/476 35/18639 0.0285714285714286 1.118787515006 0.59597305542484 0.766251071260509 GO:0003714 transcription corepressor activity 5/476 204/18639 0.0245098039215686 0.959744191794365 0.599238428367312 0.76909298288692 GO:0000993 RNA polymerase II complex binding 1/476 36/18639 0.0277777777777778 1.08771008403361 0.606310446610487 0.774081113098153 GO:0016409 palmitoyltransferase activity 1/476 36/18639 0.0277777777777778 1.08771008403361 0.606310446610487 0.774081113098153 GO:0045505 dynein intermediate chain binding 1/476 36/18639 0.0277777777777778 1.08771008403361 0.606310446610487 0.774081113098153 GO:0030280 structural constituent of skin epidermis 1/476 37/18639 0.027027027027027 1.05831251419487 0.616383887851868 0.784195208104733 GO:0042805 actinin binding 1/476 37/18639 0.027027027027027 1.05831251419487 0.616383887851868 0.784195208104733 GO:0008094 ATP-dependent activity, acting on DNA 5/476 210/18639 0.0238095238095238 0.932322929171669 0.624822914961161 0.791160964413077 GO:0005109 frizzled binding 1/476 38/18639 0.0263157894736842 1.03046218487395 0.626200104892106 0.791160964413077 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/476 38/18639 0.0263157894736842 1.03046218487395 0.626200104892106 0.791160964413077 GO:0043531 ADP binding 1/476 38/18639 0.0263157894736842 1.03046218487395 0.626200104892106 0.791160964413077 GO:0042826 histone deacetylase binding 3/476 127/18639 0.0236220472440945 0.92498180374512 0.633228892818851 0.798657202188481 GO:0000217 DNA secondary structure binding 1/476 39/18639 0.0256410256410256 1.00404007756949 0.63576565244715 0.799670683342945 GO:0004527 exonuclease activity 2/476 84/18639 0.0238095238095238 0.932322929171669 0.636226332426485 0.799670683342945 GO:0035591 signaling adaptor activity 3/476 129/18639 0.0232558139534884 0.910641000586281 0.643712126378299 0.806920514155639 GO:0004532 RNA exonuclease activity 1/476 40/18639 0.025 0.978939075630252 0.645086918545814 0.806920514155639 GO:0050660 flavin adenine dinucleotide binding 2/476 86/18639 0.0232558139534884 0.910641000586281 0.648962364906791 0.806920514155639 GO:0015631 tubulin binding 9/476 385/18639 0.0233766233766234 0.915371603186729 0.652940204080806 0.806920514155639 GO:0001530 lipopolysaccharide binding 1/476 41/18639 0.024390243902439 0.955062512810002 0.654170128759922 0.806920514155639 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/476 41/18639 0.024390243902439 0.955062512810002 0.654170128759922 0.806920514155639 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/476 41/18639 0.024390243902439 0.955062512810002 0.654170128759922 0.806920514155639 GO:0042169 SH2 domain binding 1/476 41/18639 0.024390243902439 0.955062512810002 0.654170128759922 0.806920514155639 GO:0042287 MHC protein binding 1/476 41/18639 0.024390243902439 0.955062512810002 0.654170128759922 0.806920514155639 GO:0140318 protein transporter activity 1/476 41/18639 0.024390243902439 0.955062512810002 0.654170128759922 0.806920514155639 GO:0140828 metal cation:monoatomic cation antiporter activity 1/476 41/18639 0.024390243902439 0.955062512810002 0.654170128759922 0.806920514155639 GO:0008307 structural constituent of muscle 1/476 42/18639 0.0238095238095238 0.932322929171669 0.663021350327309 0.812340444350603 GO:0035198 miRNA binding 1/476 42/18639 0.0238095238095238 0.932322929171669 0.663021350327309 0.812340444350603 GO:0043175 RNA polymerase core enzyme binding 1/476 42/18639 0.0238095238095238 0.932322929171669 0.663021350327309 0.812340444350603 GO:0048487 beta-tubulin binding 1/476 42/18639 0.0238095238095238 0.932322929171669 0.663021350327309 0.812340444350603 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 2/476 89/18639 0.0224719101123595 0.879945236521575 0.667399601727503 0.814965342812981 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 2/476 89/18639 0.0224719101123595 0.879945236521575 0.667399601727503 0.814965342812981 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/476 43/18639 0.0232558139534884 0.910641000586281 0.671646496170413 0.817404762557356 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/476 43/18639 0.0232558139534884 0.910641000586281 0.671646496170413 0.817404762557356 GO:0140793 histone H2AXY142 phosphatase activity 2/476 90/18639 0.0222222222222222 0.870168067226891 0.673369296822629 0.817404762557356 GO:0015297 antiporter activity 3/476 135/18639 0.0222222222222222 0.870168067226891 0.673882389982128 0.817404762557356 GO:0016779 nucleotidyltransferase activity 3/476 136/18639 0.0220588235294118 0.863769772614928 0.678723843979708 0.821909771198018 GO:0016790 thiolester hydrolase activity 1/476 44/18639 0.0227272727272727 0.88994461420932 0.680051328813072 0.822151606475505 GO:0019787 ubiquitin-like protein transferase activity 11/476 479/18639 0.022964509394572 0.899234223960983 0.682516644401725 0.82376594994844 GO:0140303 intramembrane lipid transporter activity 1/476 45/18639 0.0222222222222222 0.870168067226891 0.688241464198121 0.82930252462881 GO:0051219 phosphoprotein binding 2/476 93/18639 0.021505376344086 0.84209812957441 0.690757480989003 0.830960732080831 GO:0004180 carboxypeptidase activity 1/476 46/18639 0.0217391304347826 0.851251370113263 0.696222375408279 0.834779788935256 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/476 46/18639 0.0217391304347826 0.851251370113263 0.696222375408279 0.834779788935256 GO:0001784 phosphotyrosine residue binding 1/476 47/18639 0.0212765957446809 0.833139638834257 0.703999396292788 0.84133698343843 GO:0140938 histone H3 methyltransferase activity 1/476 47/18639 0.0212765957446809 0.833139638834257 0.703999396292788 0.84133698343843 GO:0008170 N-methyltransferase activity 2/476 98/18639 0.0204081632653061 0.799133939290002 0.718037656486984 0.85670941338627 GO:0016755 aminoacyltransferase activity 11/476 496/18639 0.0221774193548387 0.868413696123611 0.725123506868059 0.863571783341848 GO:0015605 organophosphate ester transmembrane transporter activity 1/476 50/18639 0.02 0.783151260504202 0.726158440587864 0.863571783341848 GO:0016597 amino acid binding 1/476 51/18639 0.0196078431372549 0.767795353435492 0.733170575844207 0.870490797704279 GO:0008509 monoatomic anion transmembrane transporter activity 3/476 149/18639 0.0201342281879195 0.788407309232418 0.736848784395522 0.873435388332253 GO:0005080 protein kinase C binding 1/476 52/18639 0.0192307692307692 0.753030058177117 0.740003522148175 0.874331552100518 GO:0030159 signaling receptor complex adaptor activity 1/476 52/18639 0.0192307692307692 0.753030058177117 0.740003522148175 0.874331552100518 GO:0005246 calcium channel regulator activity 1/476 53/18639 0.0188679245283019 0.738821943871888 0.746661849121731 0.876516083751597 GO:0051018 protein kinase A binding 1/476 53/18639 0.0188679245283019 0.738821943871888 0.746661849121731 0.876516083751597 GO:0140296 general transcription initiation factor binding 1/476 53/18639 0.0188679245283019 0.738821943871888 0.746661849121731 0.876516083751597 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/476 53/18639 0.0188679245283019 0.738821943871888 0.746661849121731 0.876516083751597 GO:0003774 cytoskeletal motor activity 3/476 153/18639 0.0196078431372549 0.767795353435492 0.752970253383272 0.881294313576299 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/476 54/18639 0.0185185185185185 0.725140056022409 0.753150010093325 0.881294313576299 GO:0008013 beta-catenin binding 2/476 106/18639 0.0188679245283019 0.738821943871888 0.757458668523461 0.884915656015389 GO:0004386 helicase activity 3/476 155/18639 0.0193548387096774 0.757888316616969 0.760728992688811 0.887314297072229 GO:0019888 protein phosphatase regulator activity 2/476 107/18639 0.0186915887850467 0.731917065891777 0.762036577317121 0.887419592434794 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/476 57/18639 0.0175438596491228 0.686974789915966 0.771636347379329 0.897165705326205 GO:0061980 regulatory RNA binding 1/476 58/18639 0.0172413793103448 0.675130396986381 0.777486153570667 0.902527716485694 GO:0036002 pre-mRNA binding 1/476 59/18639 0.0169491525423729 0.663687508901866 0.78318641679118 0.904822342061443 GO:0045309 protein phosphorylated amino acid binding 1/476 59/18639 0.0169491525423729 0.663687508901866 0.78318641679118 0.904822342061443 GO:0070888 E-box binding 1/476 59/18639 0.0169491525423729 0.663687508901866 0.78318641679118 0.904822342061443 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/476 60/18639 0.0166666666666667 0.652626050420168 0.788740952076831 0.909797712126598 GO:0015179 L-amino acid transmembrane transporter activity 1/476 62/18639 0.0161290322580645 0.631573597180808 0.799427615822858 0.92066782296187 GO:0003730 mRNA 3'-UTR binding 5/476 262/18639 0.0190839694656489 0.74728173712233 0.80246463903441 0.922707763179945 GO:0019208 phosphatase regulator activity 2/476 117/18639 0.0170940170940171 0.669360051712993 0.803829854057571 0.92282198993381 GO:0005201 extracellular matrix structural constituent 3/476 168/18639 0.0178571428571429 0.699242196878752 0.806451464901773 0.924375971561938 GO:0004842 ubiquitin-protein transferase activity 9/476 449/18639 0.0200445434298441 0.784895472665681 0.81355817355022 0.931057941158729 GO:0016757 glycosyltransferase activity 5/476 267/18639 0.0187265917602996 0.733287697101312 0.815374789754887 0.931674328732465 GO:0008235 metalloexopeptidase activity 1/476 66/18639 0.0151515151515152 0.59329640947288 0.819209586964787 0.934030390917213 GO:0005244 voltage-gated monoatomic ion channel activity 3/476 173/18639 0.0173410404624277 0.679032884830233 0.821972021630459 0.934030390917213 GO:0140030 modification-dependent protein binding 3/476 173/18639 0.0173410404624277 0.679032884830233 0.821972021630459 0.934030390917213 GO:0008173 RNA methyltransferase activity 1/476 67/18639 0.0149253731343284 0.58444123918224 0.823842992263056 0.934030390917213 GO:0042054 histone methyltransferase activity 1/476 67/18639 0.0149253731343284 0.58444123918224 0.823842992263056 0.934030390917213 GO:0022832 voltage-gated channel activity 3/476 175/18639 0.0171428571428571 0.671272509003601 0.827877172329478 0.936237060411553 GO:0030145 manganese ion binding 1/476 68/18639 0.0147058823529412 0.575846515076619 0.828357892956723 0.936237060411553 GO:0016279 protein-lysine N-methyltransferase activity 1/476 69/18639 0.0144927536231884 0.567500913408842 0.832757313717727 0.939752448452358 GO:0008017 microtubule binding 5/476 276/18639 0.0181159420289855 0.709376141761052 0.836904469730299 0.941674727448014 GO:0016278 lysine N-methyltransferase activity 1/476 70/18639 0.0142857142857143 0.559393757503001 0.837044202176013 0.941674727448014 GO:0140299 molecular sensor activity 1/476 71/18639 0.0140845070422535 0.551514972186057 0.841221430877839 0.944915906178652 GO:0005518 collagen binding 1/476 72/18639 0.0138888888888889 0.543855042016807 0.845291799194413 0.948027264019581 GO:0005262 calcium channel activity 2/476 131/18639 0.0152671755725191 0.597825389697864 0.851366724462813 0.953084442178464 GO:0008237 metallopeptidase activity 3/476 184/18639 0.016304347826087 0.638438527584947 0.852415715089655 0.953084442178464 GO:0003724 RNA helicase activity 1/476 77/18639 0.012987012987013 0.508539779548183 0.864133821202839 0.964706823364272 GO:0008186 ATP-dependent activity, acting on RNA 1/476 79/18639 0.0126582278481013 0.495665354749495 0.871012905050013 0.967939646008322 GO:0015370 solute:sodium symporter activity 1/476 79/18639 0.0126582278481013 0.495665354749495 0.871012905050013 0.967939646008322 GO:0046332 SMAD binding 1/476 79/18639 0.0126582278481013 0.495665354749495 0.871012905050013 0.967939646008322 GO:0140101 catalytic activity, acting on a tRNA 2/476 139/18639 0.0143884892086331 0.563418173024606 0.873577202235786 0.969311690152037 GO:0015101 organic cation transmembrane transporter activity 1/476 81/18639 0.0123456790123457 0.483426704014939 0.877544386433593 0.972233826307126 GO:0042393 histone binding 4/476 247/18639 0.0161943319838057 0.634130575307046 0.879123540882506 0.972505404102196 GO:0042277 peptide binding 4/476 249/18639 0.0160642570281124 0.629037157031487 0.882919805151934 0.974660641980969 GO:0030165 PDZ domain binding 1/476 83/18639 0.0120481927710843 0.471777867773615 0.883745794717998 0.974660641980969 GO:0008194 UDP-glycosyltransferase activity 2/476 145/18639 0.0137931034482759 0.540104317589105 0.888186066058684 0.978078009300273 GO:0015085 calcium ion transmembrane transporter activity 2/476 147/18639 0.0136054421768707 0.532755959526668 0.892697593622778 0.981563417422331 GO:0008081 phosphoric diester hydrolase activity 1/476 87/18639 0.0114942528735632 0.450086931324254 0.895224142640914 0.982859036122329 GO:0004197 cysteine-type endopeptidase activity 1/476 88/18639 0.0113636363636364 0.44497230710466 0.897912440835337 0.984328074239038 GO:0051015 actin filament binding 3/476 209/18639 0.0143540669856459 0.562070282658518 0.905234866250693 0.989747366307616 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 1/476 91/18639 0.010989010989011 0.430302890386924 0.905571321436461 0.989747366307616 GO:0052689 carboxylic ester hydrolase activity 1/476 92/18639 0.0108695652173913 0.425625685056631 0.90799465823807 0.990910338107115 GO:0061659 ubiquitin-like protein ligase activity 6/476 372/18639 0.0161290322580645 0.631573597180808 0.916402606197819 0.997841093273748 GO:0004896 cytokine receptor activity 1/476 96/18639 0.0104166666666667 0.407891281512605 0.917083034970386 0.997841093273748 GO:0030527 structural constituent of chromatin 1/476 98/18639 0.0102040816326531 0.399566969645001 0.921285476127173 0.998183489939909 GO:0042626 ATPase-coupled transmembrane transporter activity 1/476 98/18639 0.0102040816326531 0.399566969645001 0.921285476127173 0.998183489939909 GO:0008083 growth factor activity 2/476 162/18639 0.0123456790123457 0.483426704014939 0.921505471508312 0.998183489939909 GO:0005126 cytokine receptor binding 4/476 275/18639 0.0145454545454545 0.569564553093965 0.923575959112837 0.998941949841629 GO:0008238 exopeptidase activity 1/476 102/18639 0.00980392156862745 0.383897676717746 0.929063392100608 0.999917698073564 GO:0015171 amino acid transmembrane transporter activity 1/476 102/18639 0.00980392156862745 0.383897676717746 0.929063392100608 0.999917698073564 GO:0004497 monooxygenase activity 1/476 106/18639 0.00943396226415094 0.369410971935944 0.936074213098004 0.999917698073564 GO:0015291 secondary active transmembrane transporter activity 4/476 287/18639 0.0139372822299652 0.545750007320001 0.937660367471958 0.999917698073564 GO:0003779 actin binding 7/476 443/18639 0.0158013544018059 0.618742530872394 0.937999084095814 0.999917698073564 GO:0004843 cysteine-type deubiquitinase activity 1/476 108/18639 0.00925925925925926 0.362570028011204 0.939315858887432 0.999917698073564 GO:0005216 monoatomic ion channel activity 7/476 448/18639 0.015625 0.611836922268908 0.942258221005372 0.999917698073564 GO:0004222 metalloendopeptidase activity 1/476 110/18639 0.00909090909090909 0.355977845683728 0.942393450192302 0.999917698073564 GO:0005200 structural constituent of cytoskeleton 1/476 112/18639 0.00892857142857143 0.349621098439376 0.945315272953068 0.999917698073564 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 2/476 181/18639 0.0110497237569061 0.432680254422211 0.947615971997191 0.999917698073564 GO:0061630 ubiquitin protein ligase activity 5/476 353/18639 0.0141643059490085 0.554639702906658 0.94923231884609 0.999917698073564 GO:0017124 SH3 domain binding 1/476 115/18639 0.00869565217391304 0.340500548045305 0.949423043921633 0.999917698073564 GO:0035401 histone H3Y41 kinase activity 1/476 115/18639 0.00869565217391304 0.340500548045305 0.949423043921633 0.999917698073564 GO:0101005 deubiquitinase activity 1/476 115/18639 0.00869565217391304 0.340500548045305 0.949423043921633 0.999917698073564 GO:0140801 histone H2AXY142 kinase activity 1/476 115/18639 0.00869565217391304 0.340500548045305 0.949423043921633 0.999917698073564 GO:0015294 solute:monoatomic cation symporter activity 1/476 116/18639 0.00862068965517241 0.33756519849319 0.950722689305637 0.999917698073564 GO:0008234 cysteine-type peptidase activity 2/476 187/18639 0.0106951871657754 0.418797465510268 0.953976429642832 0.999917698073564 GO:0016758 hexosyltransferase activity 2/476 197/18639 0.0101522842639594 0.397538710915838 0.962969831462406 0.999917698073564 GO:0019783 ubiquitin-like protein peptidase activity 1/476 127/18639 0.0078740157480315 0.30832726791504 0.962996433847225 0.999917698073564 GO:0005179 hormone activity 1/476 132/18639 0.00757575757575758 0.29664820473644 0.967515827127228 0.999917698073564 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 3/476 268/18639 0.0111940298507463 0.43833092938668 0.969061016394838 0.999917698073564 GO:0005516 calmodulin binding 2/476 207/18639 0.00966183574879227 0.378333942272561 0.970263948462969 0.999917698073564 GO:0019838 growth factor binding 1/476 136/18639 0.00735294117647059 0.287923257538309 0.970731312396615 0.999917698073564 GO:0070851 growth factor receptor binding 1/476 139/18639 0.00719424460431655 0.281709086512303 0.972932676125148 0.999917698073564 GO:0004713 protein tyrosine kinase activity 1/476 140/18639 0.00714285714285714 0.279696878751501 0.973629111052955 0.999917698073564 GO:0001217 DNA-binding transcription repressor activity 3/476 278/18639 0.0107913669064748 0.422563629768454 0.974620836914712 0.999917698073564 GO:0005261 monoatomic cation channel activity 4/476 341/18639 0.0117302052785924 0.459326252495133 0.976181944022442 0.999917698073564 GO:0019955 cytokine binding 1/476 144/18639 0.00694444444444444 0.271927521008403 0.976240550692855 0.999917698073564 GO:0015293 symporter activity 1/476 146/18639 0.00684931506849315 0.268202486474042 0.977447824146951 0.999917698073564 GO:0045182 translation regulator activity 4/476 356/18639 0.0112359550561798 0.439972618260787 0.981977943344037 0.999917698073564 GO:0005085 guanyl-nucleotide exchange factor activity 2/476 230/18639 0.00869565217391304 0.340500548045305 0.982165205942225 0.999917698073564 GO:0140375 immune receptor activity 1/476 156/18639 0.00641025641025641 0.251010019392372 0.982625528278215 0.999917698073564 GO:0001664 G protein-coupled receptor binding 3/476 297/18639 0.0101010101010101 0.395530939648587 0.982678134548499 0.999917698073564 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 6/476 484/18639 0.012396694214876 0.485424335023266 0.985689946433991 0.999917698073564 GO:0015081 sodium ion transmembrane transporter activity 1/476 164/18639 0.00609756097560976 0.238765628202501 0.985899145841892 0.999917698073564 GO:0015103 inorganic anion transmembrane transporter activity 1/476 165/18639 0.00606060606060606 0.237318563789152 0.986262447957142 0.999917698073564 GO:0001216 DNA-binding transcription activator activity 6/476 491/18639 0.0122199592668024 0.478503825155317 0.987294989232668 0.999917698073564 GO:0022836 gated channel activity 3/476 318/18639 0.00943396226415094 0.369410971935944 0.988731490410175 0.999917698073564 GO:0004252 serine-type endopeptidase activity 1/476 176/18639 0.00568181818181818 0.22248615355233 0.989692068301508 0.999917698073564 GO:0046943 carboxylic acid transmembrane transporter activity 1/476 188/18639 0.00531914893617021 0.208284909708564 0.992466305408086 0.999917698073564 GO:0008514 organic anion transmembrane transporter activity 2/476 269/18639 0.00743494423791822 0.291134297585205 0.99263809190122 0.999917698073564 GO:0005342 organic acid transmembrane transporter activity 1/476 189/18639 0.00529100529100529 0.20718287314926 0.992660660111124 0.999917698073564 GO:0004175 endopeptidase activity 4/476 405/18639 0.00987654320987654 0.386741363211951 0.992962138974721 0.999917698073564 GO:0005096 GTPase activator activity 2/476 271/18639 0.00738007380073801 0.2889857049831 0.992968422543112 0.999917698073564 GO:0008236 serine-type peptidase activity 1/476 194/18639 0.00515463917525773 0.201843108377372 0.993559900161917 0.999917698073564 GO:0017171 serine hydrolase activity 1/476 198/18639 0.00505050505050505 0.197765469824293 0.994199440929972 0.999917698073564 GO:0046873 metal ion transmembrane transporter activity 4/476 450/18639 0.00888888888888889 0.348067226890756 0.997132280319405 0.999917698073564 GO:0030371 translation repressor activity 2/476 329/18639 0.0060790273556231 0.238039896809788 0.998177354413602 0.999917698073564 GO:0030695 GTPase regulator activity 4/476 489/18639 0.0081799591002045 0.320307264009899 0.998712179157505 0.999917698073564 GO:0060589 nucleoside-triphosphatase regulator activity 4/476 490/18639 0.00816326530612245 0.319653575716001 0.99873865904062 0.999917698073564 GO:0004674 protein serine/threonine kinase activity 3/476 433/18639 0.0069284064665127 0.271299512876744 0.999045738419695 0.999917698073564 GO:0106310 protein serine kinase activity 2/476 361/18639 0.00554016620498615 0.216939407341884 0.999146142840011 0.999917698073564 GO:0141003 histone H2AX kinase activity 1/476 354/18639 0.00282485875706215 0.110614584816978 0.999903583334027 0.999917698073564 GO:0140996 histone H3 kinase activity 1/476 357/18639 0.00280112044817927 0.109685050490785 0.999910919240157 0.999917698073564 GO:0035173 histone kinase activity 1/476 360/18639 0.00277777777777778 0.108771008403361 0.999917698073564 0.999917698073564