category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/87	100/9376	8.6216091954023	CCL3L1/CCL4L2/CCL4/CCL13/CCL8/CCL2/TNFRSF1A/IL6ST	7.41527205519633
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/87	103/9376	7.32418256890972	CCL3L1/C1QC/C1QB/C1QA/CCL2/TNFRSF1A/GNAQ	6.24559278064129
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/87	193/9376	4.46715502352451	CCL3L1/CCL4L2/GNG10/CCL4/CCL13/CCL8/CCL2/GNAQ	4.70999456182955
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/87	105/9376	6.15829228243021	CCL4L2/CCL4/CCL13/LY96/TNFRSF1A/VCAM1	5.14396599360075
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	10/87	298/9376	3.61644681015197	CCL3L1/CCL4L2/CCL4/EBI3/CCL13/CCL8/CCL2/TNFRSF1A/TNFSF18/IL6ST	4.4420734593976
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/87	160/9376	4.71494252873563	HLA-DRB1/CD28/JAML/SIGLEC1/PTPRM/CD99/VCAM1	4.58671378737366
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/87	88/9376	6.12330198537095	C1QC/C1QB/CD59/C1QA/VSIG4	4.67294824719975
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/87	144/9376	4.4904214559387	C1QC/C1QB/LPIN2/C1QA/LY96/TNFRSF1A	4.08481131858424
NA	NA	hsa04981	Folate transport and metabolism	3/87	31/9376	10.4293659621802	DHFR/SLCO2B1/FOLR2	5.08902364294164
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	7/87	216/9376	3.49255002128565	CCL3L1/HSPA1B/CCL2/LY96/TNFRSF1A/HSP90B1/VCAM1	3.58660710470854
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	7/87	227/9376	3.32330750924097	CCL3L1/CCL4L2/GNG10/CCL4/CCL2/TNFRSF1A/GNAQ	3.42920615051419
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/87	174/9376	3.7162108600872	HSPA1B/MAN1A1/HSP90B1/DNAJB1/HSPH1/EDEM3	3.49991723210994
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/87	78/9376	5.52667256115532	C1QC/C1QB/C1QA/LY96	3.88501226529131
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/87	142/9376	3.79472235713129	CCL2/TNFRSF1A/HSP90B1/VCAM1/MEF2C	3.24749648256332
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/87	143/9376	3.76818583715135	HLA-DRB1/C1QC/C1QB/C1QA/CD28	3.22814197085164
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/87	95/9376	4.53768905021174	CCL3L1/HLA-DRB1/CD28/CCL2	3.3538594349668
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/87	99/9376	4.35434807848601	HLA-DRB1/C1QC/C1QB/C1QA	3.24700329342776
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/87	157/9376	3.43216926568563	C1QC/C1QB/C1QA/GAS6/XKR6	2.97414746453591
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/87	106/9376	4.0667967902841	FOLR2/PDGFC/IGF1/HSP90B1	3.07297373758321
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/87	109/9376	3.95486660339555	CCL3L1/CCL4L2/CCL4/LY96	3.0029100961415
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/87	112/9376	3.84893267651888	HLA-DRB1/HSPA1B/LY96/TNFRSF1A	2.93530144052171
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	6/87	238/9376	2.71689365401333	C1QC/C1QB/C1QA/CCL2/TNFRSF1A/IL6ST	2.59637297565435
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/87	30/9376	7.18467432950191	DHFR/FOLR2	3.28341182335762
Human Diseases	Immune disease	hsa05310	Asthma	2/87	32/9376	6.73563218390805	PRG2/HLA-DRB1	3.14521726052882
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/87	80/9376	4.04137931034483	GAS6/PDGFC/IGF1	2.64379822259247
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/87	37/9376	5.82541161851507	GNAQ/VCAM1	2.84607160865585
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/87	39/9376	5.52667256115532	HLA-DRB1/CD28	2.74137525264942
NA	NA	hsa04081	Hormone signaling	5/87	219/9376	2.46050490736367	GNG10/SLC40A1/IGF1/GNAQ/THRB	2.11645604779018
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/87	155/9376	2.78116425658139	HLA-DRB1/MRC1/CD209/COLEC12	2.16392195129166
NA	NA	hsa04517	IgSF CAM signaling	6/87	299/9376	2.16261100219121	CD28/JAML/ROBO1/CD209/KCNQ3/PMP22	1.97724113945694
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/87	44/9376	4.89864158829676	HLA-DRB1/CD28	2.50849400536279
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/87	45/9376	4.78978288633461	HLA-DRB1/CD28	2.46613743426783
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/87	100/9376	3.23310344827586	HLA-DRB1/CD59/CD37	2.17264742547437
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/87	166/9376	2.59687023957901	KCNMA1/ADORA3/GNAQ/MEF2C	2.00888297934624
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/87	105/9376	3.07914614121511	CD209/EGR3/EGR2	2.07337166266546
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/87	173/9376	2.49179456514517	HLA-DRB1/CCL2/TNFRSF1A/DNAJB1	1.91658526204398
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/87	50/9376	4.31080459770115	HLA-DRB1/CD28	2.2715987932985
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/87	50/9376	4.31080459770115	CCL2/VCAM1	2.2715987932985
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	5/87	248/9376	2.17278457545421	NAIP/LY96/DCTN5/TNFRSF1A/HSP90B1	1.8114112190703
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/87	109/9376	2.96614995254666	HLA-DRB1/EBI3/IL6ST	1.99811779531631
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/87	53/9376	4.0667967902841	CLTA/GNAQ	2.16673538477735
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	4/87	181/9376	2.38165999872992	HLA-DRB1/MRC1/CD209/TNFRSF1A	1.81645811450915
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/87	54/9376	3.99148573861218	HLA-DRB1/CD28	2.13348724332106
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/87	115/9376	2.81139430284858	GNG10/KCNQ3/GNAQ	1.89144518010702
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/87	56/9376	3.84893267651888	MGAT5/MAN1A1	2.06932653566489
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/87	56/9376	3.84893267651888	NAIP/HSPA1B	2.06932653566489
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/87	119/9376	2.71689365401333	CCL2/TNFRSF1A/VCAM1	1.82407431187234
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/87	12/9376	8.98084291187739	CD209	2.67713003319012
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/87	60/9376	3.59233716475096	IGF1/GNAQ	1.94945472971459
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/87	125/9376	2.58648275862069	ADORA3/TNFRSF1A/GNAQ	1.72805199519882
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/87	62/9376	3.47645532072673	HSPA1B/IGF1	1.89329813910278
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/87	201/9376	2.14467890432893	MAF/IGF1/NR4A3/MEF2C	1.58759402027024
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/87	14/9376	7.69786535303777	B3GNT7	2.42703978320926
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/87	66/9376	3.26576105886451	HLA-DRB1/MAF	1.78760688527442
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/87	136/9376	2.37728194726166	CD28/HSPA1B/CD209	1.56573084268936
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/87	69/9376	3.12377144760953	KCNMA1/GNAQ	1.71351633626536
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/87	70/9376	3.07914614121511	HLA-DRB1/CD28	1.68971436232666
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/87	139/9376	2.32597370379558	HSPA1B/GNAQ/HSP90B1	1.5241847876667
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/87	140/9376	2.30935960591133	GNG10/GNAQ/MEF2C	1.51057320742095
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/87	300/9376	1.79616858237548	HSPA1B/PDGFC/IGF1/TNFRSF1A/MEF2C	1.35637320797925
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/87	17/9376	6.3394185260311	CD209	2.1323794284582
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/87	73/9376	2.9526058888364	PDGFC/IGF1	1.62078458453149
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/87	75/9376	2.87386973180077	GNAQ/HSP90B1	1.57676143319987
NA	NA	hsa04518	Integrin signaling	3/87	154/9376	2.09941782355575	PDGFC/IGF1/VCAM1	1.33128597856803
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/87	82/9376	2.62853938884216	HLA-DRB1/HSPA1B	1.43339089782202
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/87	238/9376	1.81126243600889	GNG10/RGL1/PDGFC/IGF1	1.22683187749766
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/87	83/9376	2.59687023957901	CCL4L2/CCL4	1.41413700770864
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/87	158/9376	2.04626800523789	LPIN2/IGF1/TNFRSF1A	1.28355333512539
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/87	22/9376	4.89864158829676	HNMT	1.77168599429387
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/87	86/9376	2.50628174284951	KCNMA1/GNAQ	1.35802687272958
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/87	23/9376	4.68565717141429	RPA1	1.71263245547239
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/87	23/9376	4.68565717141429	PRCP	1.71263245547239
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/87	89/9376	2.42180033578716	PDGFC/GNAQ	1.30423747899171
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	4/87	250/9376	1.72432183908046	FOLR2/HSPA1B/CLTA/EPS15	1.12336822381157
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/87	93/9376	2.31763688048449	HLA-DRB1/MAF	1.23581603019394
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/87	93/9376	2.31763688048449	KCNMA1/GNAQ	1.23581603019394
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/87	94/9376	2.29298116898997	CCL2/HSP90B1	1.21925944257923
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/87	97/9376	2.22206422561915	GNG10/GNAQ	1.17081989551543
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/87	28/9376	3.84893267651888	PPT1	1.46104177382122
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/87	28/9376	3.84893267651888	DHFR	1.46104177382122
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/87	180/9376	1.79616858237548	HLA-DRB1/CCL2/TNFRSF1A	1.043764664494
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/87	99/9376	2.177174039243	IGF1/GNAQ	1.1395024883896
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/87	99/9376	2.177174039243	IGF1/TTN	1.1395024883896
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/87	101/9376	2.13406168203027	CCL2/VCAM1	1.10892247974848
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/87	102/9376	2.11313950867703	KCNMA1/GNAQ	1.09389823251869
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	4/87	275/9376	1.56756530825496	C1QC/C1QB/C1QA/HSPA1B	0.924481904134328
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/87	105/9376	2.0527640941434	IGF1/TTN	1.04984021902036
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/87	32/9376	3.36781609195402	TNFRSF1A	1.29842636406601
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/87	194/9376	1.66654816921436	MYO1D/DCTN5/KIF16B	0.907871836197661
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/87	110/9376	1.9594566353187	IGF1/EGLN3	0.979571922350002
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/87	110/9376	1.9594566353187	CPEB4/IGF1	0.979571922350002
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/87	196/9376	1.64954257565095	GNG10/TNFRSF1A/IL6ST	0.889354898043895
NA	NA	hsa04082	Neuroactive ligand signaling	3/87	199/9376	1.62467509963611	ADORA3/GNG10/GNAQ	0.861968013783744
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/87	200/9376	1.61655172413793	NAIP/MYO1D/TNFRSF1A	0.852940222295068
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/87	36/9376	2.99361430395913	RPA1	1.15979100547722
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/87	115/9376	1.87426286856572	GNG10/GNAQ	0.912899133167583
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/87	115/9376	1.87426286856572	GNAQ/MEF2C	0.912899133167583
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/87	116/9376	1.8581054300436	CD99/VCAM1	0.899963579752267
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/87	116/9376	1.8581054300436	GNG10/GNAQ	0.899963579752267
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	3/87	204/9376	1.58485463150778	DCN/IGF1/LUM	0.817319342995978
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/87	205/9376	1.5771236333053	EGR3/IL6ST/EGR2	0.808533885786829
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/87	38/9376	2.83605565638234	IGF1	1.09751758742035
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/87	39/9376	2.76333628057766	DHFR	1.06788515766661
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/87	122/9376	1.76672319577916	IGF1/GNAQ	0.824925166412661
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/87	212/9376	1.52504879635654	PDGFC/IGF1/GNAQ	0.748317394607276
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/87	41/9376	2.62853938884216	RPA1	1.01133215896615
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/87	214/9376	1.51079600386723	GNG10/TNFRSF1A/GNAQ	0.731509578122821
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/87	42/9376	2.56595511767926	SLC40A1	0.984307604690541
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/87	44/9376	2.44932079414838	MAN1A1	0.932533150747302
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/87	44/9376	2.44932079414838	MBD4	0.932533150747302
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/87	44/9376	2.44932079414838	DCTN5	0.932533150747302
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/87	45/9376	2.39489144316731	ABCA9	0.907702131733949
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	3/87	224/9376	1.44334975369458	HLA-DRB1/TNFRSF1A/EGR2	0.649939987978986
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/87	133/9376	1.62060323221848	GNG10/GNAQ	0.697580224124417
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/87	134/9376	1.6085091782467	KCNMA1/GNAQ	0.686589777975159
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/87	138/9376	1.56188572380476	CPEB4/IGF1	0.643515993678207
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/87	138/9376	1.56188572380476	CCL2/GNAQ	0.643515993678207
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	3/87	233/9376	1.38759804647033	MYOM2/DCN/TTN	0.579796999081009
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/87	51/9376	2.11313950867703	ENPP2	0.77138474920921
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/87	52/9376	2.07250221043325	IGF1	0.750515245063045
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/87	52/9376	2.07250221043325	PLTP	0.750515245063045
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/87	144/9376	1.49680715197957	IGF1/IL6ST	0.581409294888134
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/87	54/9376	1.99574286930609	RPA1	0.710150371727332
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/87	149/9376	1.44657872406079	GNG10/GNAQ	0.531767370757332
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/87	57/9376	1.89070377092156	PPT1	0.652749948163542
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/87	154/9376	1.3996118823705	GNAQ/MEF2C	0.483890368584742
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	4/87	362/9376	1.19082999936496	GNG10/PDGFC/IGF1/HSP90B1	0.358346312931283
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/87	61/9376	1.76672319577916	SLC40A1	0.581397116061293
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/87	63/9376	1.7106367451195	RPA1	0.54768887108949
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/87	163/9376	1.32233269868133	EGR3/EGR2	0.401752339050215
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/87	65/9376	1.6580017683466	LPIN2	0.515165010888047
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/87	65/9376	1.6580017683466	GNAQ	0.515165010888047
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/87	65/9376	1.6580017683466	GNAQ	0.515165010888047
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/87	67/9376	1.6085091782467	GNAQ	0.483742007333886
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/87	169/9376	1.27538597565123	WDFY3/C9orf72	0.349612444766883
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/87	70/9376	1.53957307060755	TNFRSF1A	0.438509034481552
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/87	70/9376	1.53957307060755	SULT1A1	0.438509034481552
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/87	70/9376	1.53957307060755	EGLN3	0.438509034481552
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/87	75/9376	1.43693486590038	IGF1	0.367657384972014
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/87	76/9376	1.41802782819117	PLTP	0.354104380044467
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/87	76/9376	1.41802782819117	GNAQ	0.354104380044467
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/87	76/9376	1.41802782819117	IGF1	0.354104380044467
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/87	78/9376	1.38166814028883	CLTA	0.327566305329269
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/87	78/9376	1.38166814028883	HLA-DRB1	0.327566305329269
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/87	187/9376	1.15262155018747	NAIP/CCL2	0.20401557372322
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/87	79/9376	1.36417867015859	CLTA	0.314570084449408
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	3/87	308/9376	1.04970891177788	CLTA/DCTN5/GNAQ	0.0858449281178097
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/87	86/9376	1.25314087142475	SCN9A	0.228225634157039
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	2/87	203/9376	1.06177453145349	PDGFC/IGF1	0.0861117797596487
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/87	89/9376	1.21090016789358	GNG10	0.193461695266915
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/87	90/9376	1.19744572158365	IGF1	0.182144233152731
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/87	90/9376	1.19744572158365	CD28	0.182144233152731
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/87	91/9376	1.18428697739043	GNG10	0.170956324526098
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/87	93/9376	1.15881844024224	PTPRM	0.148956345445944
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/87	93/9376	1.15881844024224	GNAQ	0.148956345445944
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/87	98/9376	1.09969505043397	GNAQ	0.0960108322340413
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/87	99/9376	1.0885870196215	IGF1	0.0857520858705264
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/87	99/9376	1.0885870196215	PDGFC	0.0857520858705264
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/87	101/9376	1.06703084101514	GNAQ	0.0655449413519174
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/87	103/9376	1.04631179555853	PRCP	0.0457362849423186
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/87	103/9376	1.04631179555853	GNAQ	0.0457362849423186
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/87	104/9376	1.03625110521662	LPIN2	0.0359759269765523
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/87	107/9376	1.00719733591148	GNAQ	0.00724616140014057
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/87	109/9376	0.988716650848887	TNFRSF1A	-0.011466806334076
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/87	110/9376	0.979728317659352	DCN	-0.0206966840487803
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	4/87	480/9376	0.898084291187739	DCTN5/TNFRSF1A/GNAQ/C9orf72	-0.221832484831033
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/87	117/9376	0.921112093525887	PBRM1	-0.0830963796481055
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/87	368/9376	0.87856071964018	DCTN5/TNFRSF1A/C9orf72	-0.230000981127657
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/87	250/9376	0.86216091954023	PPT1/CLTA	-0.213777957025967
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/87	122/9376	0.88336159788958	IGF1	-0.125492425168208
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/87	122/9376	0.88336159788958	CD28	-0.125492425168208
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/87	122/9376	0.88336159788958	THRB	-0.125492425168208
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	2/87	253/9376	0.851937667529871	NAIP/TNFRSF1A	-0.231045116201091
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/87	254/9376	0.848583582224636	PDGFC/GNAQ	-0.236758497279471
Organismal Systems	Immune system	hsa04611	Platelet activation	1/87	126/9376	0.855318372559752	GNAQ	-0.158229907611954
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/87	130/9376	0.829000884173298	GNG10	-0.189998153157917
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/87	133/9376	0.810301616109239	IGF1	-0.21322776659979
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/87	137/9376	0.786643174762983	TNFRSF1A	-0.243452996017447
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/87	142/9376	0.758944471426259	UBE2W	-0.280109034497873
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/87	142/9376	0.758944471426259	TNFRSF1A	-0.280109034497873
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/87	144/9376	0.748403575989783	GNAQ	-0.294441211035893
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/87	148/9376	0.728176452314383	IGF1	-0.322570705584742
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/87	149/9376	0.723289362030394	PDGFC	-0.329495518899041
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/87	154/9376	0.699805941185252	DHFR	-0.363505241398549
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/87	154/9376	0.699805941185252	GNAQ	-0.363505241398549
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/87	155/9376	0.695291064145347	GNAQ	-0.370188404923495
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/87	156/9376	0.690834070144415	TNFRSF1A	-0.376833279802872
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/87	157/9376	0.686433853137126	TNFRSF1A	-0.38344040187253
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/87	168/9376	0.641488779419814	TNFRSF1A	-0.45376972957599
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/87	168/9376	0.641488779419814	IL6ST	-0.45376972957599
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/87	170/9376	0.63394185260311	PBRM1	-0.466122251894482
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/87	178/9376	0.605450083946791	NOTUM	-0.514311265129004
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/87	184/9376	0.585707146426787	ROBO1	-0.549252609142533
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/87	191/9376	0.564241439489679	GNG10	-0.588821709754518
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	1/87	205/9376	0.525707877768433	HLA-DRB1	-0.6644698474566
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/87	370/9376	0.582541161851507	ADORA3/THRB	-0.792883415347581
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/87	217/9376	0.496636474389533	HSP90B1	-0.726019630067686
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	2/87	388/9376	0.555516056404787	TNFRSF1A/GNAQ	-0.86536871663855
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/87	232/9376	0.4645263575109	PDGFC	-0.799235498947165
NA	NA	hsa04519	Cadherin signaling	2/87	404/9376	0.533515420507568	MYO1D/FMN1	-0.927564513321075
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/87	243/9376	0.443498415401353	HSPA1B	-0.85059650974546
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	1/87	333/9376	0.323633978806393	TNFRSF1A	-1.2162095690599