category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	21/112	368/9376	4.77717391304348	MT-CO1/TUBB4B/MT-CO3/MT-ATP6/SRSF3/HNRNPA1/HSPA5/SRSF7/MT-CO2/TUBB2A/TUBA1B/ACTG1/CYCS/MT-ND2/TUBA4A/MAP1LC3B/FUS/ACTB/SOD1/NXT1/TUBA1A	8.12778259658493
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/112	275/9376	5.47948051948052	MT-CO1/TUBB4B/MT-CO3/MT-ATP6/HSPA5/MT-CO2/TUBB2A/TUBA1B/HSPA1A/HSPA1B/HSPA8/CYCS/MT-ND2/VDAC2/TUBA4A/PIK3R3/SOD1/TUBA1A	8.28981461104803
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	17/112	268/9376	5.31023454157783	MT-CO1/TUBB4B/UBB/MT-CO3/MT-ATP6/UBC/HSPA5/MT-CO2/TUBB2A/TUBA1B/DUSP1/CYCS/MT-ND2/VDAC2/TUBA4A/SOD1/TUBA1A	7.8714033148497
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/112	82/9376	10.2090592334495	B2M/HSPA5/HSPA1A/HSPA1B/HSPA8/HSP90AB1/CALR/HLA-C/HSPA2/HSP90AA1	9.20907976939939
Genetic Information Processing	Transcription	hsa03040	Spliceosome	14/112	243/9376	4.82304526748971	SRSF2/SRSF3/HNRNPA1/SRSF7/EIF4A3/DDX5/SRSF5/HSPA1A/BCAS2/HSPA1B/HSPA8/PCBP1/FUS/RBM8A	6.63897792683002
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/112	137/9376	6.11053180396246	GADD45B/FOS/TUBA1B/ACTG1/CYCS/TUBA4A/PIK3R3/ACTB/GADD45A/TUBA1A	6.62535680158624
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/112	174/9376	5.29228243021347	DNAJA1/HSPA5/HERPUD1/HSPA1A/HSPA1B/HSPA8/HSP90AB1/CALR/DNAJB1/UBE2D3/HSP90AA1	6.28372509038241
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	13/112	248/9376	4.38824884792627	TUBB4B/DYNLL1/FOS/TUBB2A/TUBA1B/MYL12A/ACTG1/CYCS/HSP90AB1/TUBA4A/ACTB/TUBA1A/HSP90AA1	5.94577814573675
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/112	42/9376	11.9591836734694	FTL/SAT1/VDAC2/MAP1LC3B/PCBP1/SLC3A2	7.82644123963627
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	18/112	480/9376	3.13928571428571	MT-CO1/TUBB4B/UBB/MT-CO3/MT-ATP6/UBC/HSPA5/MT-CO2/TUBB2A/TUBA1B/CYCS/MT-ND2/VDAC2/TUBA4A/MAP1LC3B/FUS/SOD1/TUBA1A	5.29038646947085
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/112	142/9376	5.30583501006036	FOS/DUSP1/ACTG1/HSP90AB1/KLF2/PIK3R3/GSTP1/ACTB/HSP90AA1	5.68462732149185
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/112	56/9376	8.96938775510204	HSPA1A/HSPA1B/HSPA8/CLK1/CYCS/EEF1A1	6.57667516695412
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/112	180/9376	4.65079365079365	B2M/SRSF2/SRSF3/SRSF7/SRSF5/CYCS/SOCS3/CALR/HLA-C/PIK3R3	5.43775246779458
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	13/112	308/9376	3.53339517625232	MT-CO1/TUBB4B/MT-CO3/MT-ATP6/MT-CO2/TUBB2A/TUBA1B/CYCS/MT-ND2/VDAC2/TUBA4A/SOD1/TUBA1A	4.97070418322896
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/112	155/9376	4.86082949308756	TUBB4B/TUBB2A/TUBA1B/ACTG1/CALR/HLA-C/TUBA4A/ACTB/TUBA1A	5.32908732175391
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/112	216/9376	3.87566137566138	HSPA5/FOS/HSPA1A/HSPA1B/HSPA8/CYCS/HSP90AB1/PIK3R3/HSPA2/HSP90AA1	4.70123823216387
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/112	194/9376	3.88365243004418	TUBB4B/DYNLL1/TUBB2A/TUBA1B/MYL12A/ACTG1/TUBA4A/ACTB/TUBA1A	4.46242068741403
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/112	200/9376	3.76714285714286	TUBB4B/FOS/TUBB2A/TUBA1B/ACTG1/CYCS/TUBA4A/ACTB/TUBA1A	4.34925881572535
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	13/112	388/9376	2.80486008836524	MT-CO1/TUBB4B/MT-CO3/MT-ATP6/MT-CO2/TUBB2A/TUBA1B/CYCS/MT-ND2/VDAC2/TUBA4A/PIK3R3/TUBA1A	3.99230073379593
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/112	93/9376	5.40092165898618	GADD45B/FN1/CYCS/PIK3R3/CKS2/GADD45A	4.68960552905529
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/112	62/9376	6.75115207373272	HSPA1A/HSPA1B/HSPA8/PIK3R3/SOD1	4.99548841100208
NA	NA	hsa04517	IgSF CAM signaling	11/112	299/9376	3.07978977544195	TUBB4B/DYNLL1/TUBB2A/TUBA1B/MYL12A/ACTG1/TUBA4A/PIK3R3/ACTB/TUBA1A/LCK	4.01864128501978
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/112	300/9376	3.06952380952381	DUSP2/GADD45B/FOS/HSPA1A/DUSP1/HSPA1B/HSPA8/STMN1/NR4A1/GADD45A/MKNK2	4.00570707356233
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/112	139/9376	4.2158273381295	FOS/HSPA1A/HSPA1B/HSPA8/HSP90AB1/PIK3R3/HSP90AA1	4.19981371574814
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/112	224/9376	3.36352040816327	B2M/ZFP36/FOS/RAN/CALR/VDAC2/HLA-C/PIK3R3/LCK	3.93659499901109
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/112	227/9376	3.31906859660164	MT-CO1/MT-CO3/MT-ATP6/FOS/MT-CO2/MT-ND2/VDAC2/PIK3R3/SOD1	3.88897441619852
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/112	108/9376	4.65079365079365	SAP18/EIF4A3/RAN/NXT1/EEF1A1/RBM8A	4.19567198609083
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	9/112	238/9376	3.1656662665066	RPL14/FOS/RPL3/RPL10/RPL5/RPS3A/PIK3R3/RPL7A/RPS4X	3.72091551947116
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/112	196/9376	3.41690962099125	UBB/ZFP36/UBC/FOS/CYCS/HLA-C/PIK3R3/MAP1LC3B	3.75978042066722
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/112	157/9376	3.73248407643312	MT-CO1/MT-CO3/FOS/MT-CO2/CYCS/SOCS3/PIK3R3	3.79630358306966
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/112	253/9376	2.97797854319593	UBB/UBC/MYL12A/ACTG1/CYCS/PIK3R3/MAP1LC3B/ACTB/UBE2D3	3.50677882612422
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/112	87/9376	4.8111658456486	GADD45B/FOS/CYCS/PIK3R3/GADD45A	3.92670584636938
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/112	89/9376	4.70304975922953	TUBB4B/TUBB2A/TUBA1B/TUBA4A/TUBA1A	3.85933257125451
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/112	173/9376	3.38728323699422	ACTG1/CYCS/SOCS3/DNAJB1/PIK3R3/ACTB/NXT1	3.48463797693366
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/112	136/9376	3.69327731092437	FOS/HSPA1A/HSPA1B/HSPA8/CYCS/PIK3R3	3.47864345135233
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/112	138/9376	3.63975155279503	MT-CO1/MT-CO3/MT-ATP6/MT-CO2/CYCS/MT-ND2	3.43485963677779
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/112	138/9376	3.63975155279503	FN1/FOS/ACTG1/PIK3R3/ACTB/LCK	3.43485963677779
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/112	142/9376	3.53722334004024	UBB/UBE2S/UBC/SOCS1/SOCS3/UBE2D3	3.34967993102861
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/112	142/9376	3.53722334004024	JUNB/FOS/SOCS1/SOCS3/PIK3R3/LCK	3.34967993102861
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/112	103/9376	4.06380027739251	SAP18/EIF4A3/FUS/NXT1/RBM8A	3.43767099587606
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/112	70/9376	4.78367346938776	ACTG1/CYCS/HLA-C/ACTB	3.49362689318916
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/112	71/9376	4.71629778672032	FOS/SOCS1/SOCS3/PIK3R3	3.45602494654779
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	5/112	112/9376	3.73724489795918	HSPA1A/HSPA1B/HSPA8/CYCS/SOCS1	3.20419375345466
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/112	204/9376	2.87254901960784	FN1/DDX5/ACTG1/PIK3R3/LUM/ACTB/DCN	2.97311448303972
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/112	205/9376	2.85853658536585	B2M/GADD45B/CYCS/CALR/HLA-C/PIK3R3/GADD45A	2.95825137308968
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/112	205/9376	2.85853658536585	MT-CO1/MT-CO3/MT-ATP6/MT-CO2/MT-ND2/VDAC2/PIK3R3	2.95825137308968
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/112	78/9376	4.29304029304029	FN1/ACTG1/PIK3R3/ACTB	3.21103435004658
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/112	122/9376	3.43091334894614	JUNB/FOS/SOCS1/SOCS3/PIK3R3	2.97152933914981
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/112	170/9376	2.9546218487395	TUBA1B/MYL12A/ACTG1/TUBA4A/ACTB/TUBA1A	2.82778965110354
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/112	170/9376	2.9546218487395	GADD45B/ACTG1/PIK3R3/GSTP1/ACTB/GADD45A	2.82778965110354
Genetic Information Processing	Translation	hsa03010	Ribosome	7/112	222/9376	2.63963963963964	RPL14/RPL3/RPL10/RPL5/RPS3A/RPL7A/RPS4X	2.71840912111377
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/112	47/9376	5.3434650455927	SOCS1/SOCS3/PIK3R3	3.28218525125777
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	7/112	232/9376	2.52586206896552	FN1/TMSB4X/MYL12A/ACTG1/PIK3R3/RGCC/ACTB	2.58753681296663
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/112	133/9376	3.14715359828142	GADD45B/KLF2/PIK3R3/GADD45A/SGK1	2.74206555575781
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/112	133/9376	3.14715359828142	ULBP2/HLA-C/PIK3R3/NCR3/LCK	2.74206555575781
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/112	50/9376	5.02285714285714	SAT1/AMD1/ODC1	3.13593666892121
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/112	235/9376	2.4936170212766	MT-CO1/MT-CO3/MT-ATP6/MT-CO2/ACTG1/MT-ND2/ACTB	2.54959798481315
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/112	59/9376	4.25665859564165	GADD45B/PIK3R3/GADD45A	2.75902456411504
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/112	105/9376	3.1891156462585	GADD45B/GADD45A/LTB/LCK	2.48024989748484
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/112	105/9376	3.1891156462585	UBB/UBC/CITED2/MAP1LC3B	2.48024989748484
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/112	106/9376	3.15902964959569	HSP90AB1/PIK3R3/GSTP1/HSP90AA1	2.4579160662725
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/112	157/9376	2.66606005459509	GADD45B/VDAC2/HLA-C/PIK3R3/GADD45A	2.31469592427591
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/112	109/9376	3.07208387942333	FOS/HSP90AB1/LCK/HSP90AA1	2.39246931174702
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	6/112	214/9376	2.34712950600801	B2M/FOS/CYCS/CALR/HLA-C/PIK3R3	2.19187845521339
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/112	116/9376	2.88669950738916	MYL12A/ACTG1/PIK3R3/ACTB	2.24813099702676
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/112	168/9376	2.49149659863946	FTL/HSP90AB1/VDAC2/CHMP1B/HSP90AA1	2.1448139674017
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/112	169/9376	2.47675401521555	UBB/DDIT4/UBC/PIK3R3/MAP1LC3B	2.13004028594941
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/112	119/9376	2.81392557022809	JUNB/FOS/SOCS3/PIK3R3	2.18954153527291
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/112	73/9376	3.44031311154599	GADD45B/PIK3R3/GADD45A	2.3013933257644
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/112	73/9376	3.44031311154599	GADD45B/PIK3R3/GADD45A	2.3013933257644
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/112	75/9376	3.34857142857143	CYCS/PIK3R3/GSTP1	2.2452513130477
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/112	75/9376	3.34857142857143	GADD45B/CYCS/GADD45A	2.2452513130477
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/112	76/9376	3.30451127819549	GADD45B/PIK3R3/GADD45A	2.21788761669697
Organismal Systems	Immune system	hsa04611	Platelet activation	4/112	126/9376	2.65759637188209	MYL12A/ACTG1/PIK3R3/ACTB	2.05962696960064
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/112	77/9376	3.26159554730983	GADD45B/PIK3R3/GADD45A	2.19097567303953
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/112	77/9376	3.26159554730983	GADD45B/PIK3R3/GADD45A	2.19097567303953
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/112	78/9376	3.21978021978022	FOS/MARCKSL1/EEF1A1	2.16450146399135
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/112	37/9376	4.52509652509652	GADD45B/GADD45A	2.36220216998297
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/112	187/9376	2.23834988540871	TXNIP/HSP90AB1/VDAC2/MAP1LC3B/HSP90AA1	1.88072553950993
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/112	38/9376	4.40601503759398	PIK3R3/SGK1	2.3131660036527
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/112	250/9376	2.00914285714286	HSPA1A/HSPA1B/HSPA8/HLA-C/ARF4/CHMP1B	1.7781885073338
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/112	138/9376	2.42650103519669	SOCS1/SOCS3/PIK3R3/MKNK2	1.85617120763913
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/112	87/9376	2.88669950738916	MT-CO1/MT-CO3/MT-CO2	1.94389703467403
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/112	90/9376	2.79047619047619	FOS/PIK3R3/LCK	1.87659623898637
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/112	203/9376	2.06192821956369	FN1/MYL12A/ACTG1/PIK3R3/ACTB	1.68183296390681
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/112	93/9376	2.70046082949309	MYL12A/ACTG1/ACTB	1.81200464944649
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/112	148/9376	2.26254826254826	GADD45B/FOS/PIK3R3/GADD45A	1.70223858170698
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/112	94/9376	2.67173252279635	FOS/HSP90AB1/HSP90AA1	1.79104011307766
NA	NA	hsa04518	Integrin signaling	4/112	154/9376	2.17439703153989	FN1/ACTG1/PIK3R3/ACTB	1.6156903186229
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/112	217/9376	1.92890059249506	FOS/HSP90AB1/PIK3R3/PTGES3/HSP90AA1	1.52219556984898
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/112	157/9376	2.13284804367607	DUSP2/CALR/SGK1/ODC1	1.57389209487903
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/112	158/9376	2.11934900542495	DDIT4/PIK3R3/SGK1/SLC3A2	1.56016699279525
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/112	51/9376	3.28291316526611	ACTG1/ACTB	1.79740289468934
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/112	103/9376	2.43828016643551	FOS/CALR/PIK3R3	1.61379122803235
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/112	103/9376	2.43828016643551	FN1/PRDX1/PIK3R3	1.61379122803235
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/112	227/9376	1.84392699811202	B2M/CYCS/CALR/HLA-C/PIK3R3	1.4152278676044
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/112	54/9376	3.1005291005291	AMD1/LDHB	1.70202686024431
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/112	362/9376	1.61878453038674	DDIT4/FN1/HSP90AB1/PIK3R3/NR4A1/SGK1/HSP90AA1	1.32017143805233
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/112	110/9376	2.28311688311688	PIK3R3/LDHB/MKNK2	1.48837302519457
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/112	110/9376	2.28311688311688	HSP90AB1/PIK3R3/HSP90AA1	1.48837302519457
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/112	233/9376	1.79644389944819	FN1/MYOM2/ACTG1/ACTB/DCN	1.3535807425251
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/112	59/9376	2.83777239709443	GSTP1/ODC1	1.55695140829986
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/112	115/9376	2.18385093167702	FOS/NACA/SGK1	1.40446970165285
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/112	63/9376	2.65759637188209	GADD45B/GADD45A	1.45144183653514
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/112	16/9376	5.23214285714286	GLA	1.86284946883542
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/112	122/9376	2.05854800936768	FOS/PIK3R3/LCK	1.29396075269336
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/112	122/9376	2.05854800936768	ACTG1/PIK3R3/ACTB	1.29396075269336
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/112	18/9376	4.65079365079365	PRDX1	1.70461927542078
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/112	195/9376	1.71721611721612	ACTG1/VDAC2/PIK3R3/ACTB	1.11280156755221
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/112	71/9376	2.35814889336016	PIK3R3/LDHB	1.2630302322251
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/112	201/9376	1.66595593461265	GADD45B/DDX5/FUS/GADD45A	1.04938744041749
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/112	76/9376	2.20300751879699	ACTG1/ACTB	1.15778798914034
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/112	144/9376	1.74404761904762	CYCS/VDAC2/PIK3R3	0.989303295488962
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/112	83/9376	2.01721170395869	PRDX1/SOD1	1.0234527621795
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/112	150/9376	1.67428571428571	GADD45B/PIK3R3/GADD45A	0.915331143871608
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/112	86/9376	1.9468438538206	ACTG1/ACTB	0.969873536140714
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/112	27/9376	3.1005291005291	ELOVL5	1.2017755971301
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/112	154/9376	1.63079777365492	FOS/ACTG1/ACTB	0.867827343336156
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/112	156/9376	1.60989010989011	CYCS/SOCS3/PIK3R3	0.844585859172933
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/112	28/9376	2.98979591836735	ELOVL5	1.15937405104987
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/112	28/9376	2.98979591836735	DHFR	1.15937405104987
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/112	158/9376	1.58951175406872	GADD45B/GADD45A/CDKN1C	0.821671146447903
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/112	91/9376	1.83987441130298	FOS/PIK3R3	0.885196051711033
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/112	30/9376	2.79047619047619	DHFR	1.07996993526794
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/112	93/9376	1.80030721966206	FOS/LCK	0.852804356243562
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/112	163/9376	1.5407537248028	FOS/CYCS/PIK3R3	0.765752040207247
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/112	31/9376	2.70046082949309	HSPA5	1.042685184532
NA	NA	hsa04981	Folate transport and metabolism	1/112	31/9376	2.70046082949309	DHFR	1.042685184532
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/112	95/9376	1.76240601503759	FOS/LTB	0.821194641224103
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/112	32/9376	2.61607142857143	GLA	1.00684937037136
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/112	32/9376	2.61607142857143	LDHB	1.00684937037136
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/112	32/9376	2.61607142857143	CYCS	1.00684937037136
Human Diseases	Immune disease	hsa05310	Asthma	1/112	32/9376	2.61607142857143	PRG2	1.00684937037136
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/112	168/9376	1.49489795918367	SOCS1/SOCS3/PIK3R3	0.711677154519834
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/112	98/9376	1.70845481049563	PIK3R3/MARCKSL1	0.775163622593616
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/112	99/9376	1.69119769119769	FOS/PIK3R3	0.760171309110373
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/112	99/9376	1.69119769119769	FOS/PIK3R3	0.760171309110373
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/112	99/9376	1.69119769119769	ACTG1/ACTB	0.760171309110373
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/112	34/9376	2.46218487394958	BHLHE40	0.93911156810422
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/112	101/9376	1.65770862800566	FN1/PIK3R3	0.730689124136831
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/112	103/9376	1.625520110957	SLC38A2/SLC3A2	0.701851344110503
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/112	105/9376	1.59455782312925	ACTG1/ACTB	0.673629089621426
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/112	38/9376	2.20300751879699	NAPRT	0.817012275020822
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/112	38/9376	2.20300751879699	LCK	0.817012275020822
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/112	39/9376	2.14652014652015	DHFR	0.788870454843715
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/112	39/9376	2.14652014652015	HLA-C	0.788870454843715
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/112	109/9376	1.53604193971166	FOS/PIK3R3	0.618924698611341
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/112	109/9376	1.53604193971166	SOCS3/PIK3R3	0.618924698611341
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/112	115/9376	1.45590062111801	FOS/PIK3R3	0.540860839985935
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/112	117/9376	1.43101343101343	ACTG1/ACTB	0.515818683620413
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/112	44/9376	1.9025974025974	MBD4	0.659824487251309
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/112	44/9376	1.9025974025974	HLA-C	0.659824487251309
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/112	44/9376	1.9025974025974	DYNLL1	0.659824487251309
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/112	45/9376	1.86031746031746	HLA-C	0.636057350148875
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/112	46/9376	1.81987577639752	FTL	0.612888574778137
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/112	47/9376	1.78115501519757	LDHB	0.590288040289185
NA	NA	hsa03272	Virion - Hepatitis viruses	1/112	48/9376	1.74404761904762	CHMP1B	0.568227774169996
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/112	48/9376	1.74404761904762	PIK3R3	0.568227774169996
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/112	130/9376	1.28791208791209	FOS/PIK3R3	0.363454463708006
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/112	52/9376	1.60989010989011	VDAC2	0.484894777402843
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/112	212/9376	1.18463611859838	ACTG1/PIK3R3/ACTB	0.298976758126996
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/112	54/9376	1.55026455026455	HLA-C	0.445871016285664
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/112	55/9376	1.52207792207792	GLA	0.426953713262604
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/112	57/9376	1.46867167919799	ELOVL5	0.390226590282225
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/112	140/9376	1.19591836734694	KLF2/MAP1LC3B	0.256798560577739
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/112	59/9376	1.41888619854722	NUDT2	0.354878252484686
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/112	59/9376	1.41888619854722	PIK3R3	0.354878252484686
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/112	60/9376	1.3952380952381	PIK3R3	0.337687557821014
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/112	61/9376	1.37236533957845	FTL	0.320802772914364
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/112	63/9376	1.32879818594104	PTGES3	0.287905699449514
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/112	63/9376	1.32879818594104	ERCC5	0.287905699449514
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/112	323/9376	1.03670942061035	DDIT4/STMN1/SOCS1/PIK3R3	0.0738206572174387
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/112	65/9376	1.28791208791209	GLA	0.256102483718727
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/112	65/9376	1.28791208791209	NR4A1	0.256102483718727
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/112	65/9376	1.28791208791209	PIK3R3	0.256102483718727
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/112	154/9376	1.08719851576994	DHFR/NAPRT	0.11996436804941
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/112	67/9376	1.24946695095949	LDHB	0.225317166755087
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/112	68/9376	1.23109243697479	PIK3R3	0.210284556003027
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/112	157/9376	1.06642402183803	ACTG1/ACTB	0.0922844360852764
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/112	69/9376	1.21325051759834	PIK3R3	0.195481273072236
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/112	69/9376	1.21325051759834	FOS	0.195481273072236
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/112	70/9376	1.19591836734694	SOCS3	0.180899774404617
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/112	70/9376	1.19591836734694	GSTP1	0.180899774404617
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/112	70/9376	1.19591836734694	PIK3R3	0.180899774404617
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/112	73/9376	1.146771037182	GSTP1	0.138415797459767
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/112	73/9376	1.146771037182	RAN	0.138415797459767
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/112	75/9376	1.11619047619048	HSPA5	0.111078937628475
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/112	76/9376	1.1015037593985	UBC	0.0976883615837165
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/112	78/9376	1.07326007326007	TOB1	0.0714356918809027
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/112	78/9376	1.07326007326007	FOS	0.0714356918809027
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/112	79/9376	1.05967450271248	GSTP1	0.0585634043931574
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/112	80/9376	1.04642857142857	PIK3R3	0.0458540429342902
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/112	82/9376	1.02090592334495	GSTP1	0.0209059699645843
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/112	83/9376	1.00860585197935	UBE2D3	0.00865865281031728
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/112	83/9376	1.00860585197935	PCBP1	0.00865865281031728
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/112	86/9376	0.973421926910299	PIK3R3	-0.0272245203127218
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/112	183/9376	0.914910226385636	RAN/NXT1	-0.127811419826199
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/112	184/9376	0.909937888198758	MYL12A/PIK3R3	-0.135656749368532
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/112	89/9376	0.940609951845907	FN1	-0.0618965345194697
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/112	89/9376	0.940609951845907	SLC38A2	-0.0618965345194697
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/112	90/9376	0.93015873015873	PIK3R3	-0.0732005625136529
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/112	97/9376	0.863033873343152	FOS	-0.149088391904842
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/112	98/9376	0.854227405247813	PIK3R3	-0.159498687776464
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/112	98/9376	0.854227405247813	NR4A1	-0.159498687776464
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/112	99/9376	0.845598845598846	PIK3R3	-0.169808622285616
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/112	205/9376	0.816724738675958	HLA-C/PIK3R3	-0.291721076536403
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/112	105/9376	0.797278911564626	PIK3R3	-0.22968131431028
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/112	107/9376	0.78237650200267	LDHB	-0.248929639868591
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/112	110/9376	0.761038961038961	DCN	-0.277186879186033
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/112	115/9376	0.727950310559006	DUSP1	-0.32274802168098
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/112	116/9376	0.721674876847291	SLC38A2	-0.331643345514391
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/112	226/9376	0.740834386852086	FOS/PIK3R3	-0.433627110338677
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	3/112	333/9376	0.754182754182754	FN1/HLA-C/PIK3R3	-0.502196378005082
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/112	120/9376	0.697619047619048	PIK3R3	-0.366546229909116
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/112	122/9376	0.686182669789227	PIK3R3	-0.383607833763077
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/112	125/9376	0.669714285714286	PIK3R3	-0.408738768501965
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/112	128/9376	0.654017857142857	NUDT2	-0.433341352834138
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/112	133/9376	0.629430719656283	FOS	-0.473242929833139
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/112	144/9376	0.581349206349206	PIK3R3	-0.556647987595123
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/112	149/9376	0.561840843720038	PIK3R3	-0.592775358549815
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/112	149/9376	0.561840843720038	MT-ND2	-0.592775358549815
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/112	155/9376	0.540092165898618	NR4A1	-0.634808921832227
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/112	160/9376	0.523214285714286	HLA-C	-0.668817100894398
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/112	166/9376	0.504302925989673	VDAC2	-0.708493647510847
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/112	181/9376	0.462509865824783	CYCS	-0.802840539342782
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/112	193/9376	0.433752775721688	PIK3R3	-0.873952491524469
NA	NA	hsa04081	Hormone signaling	1/112	219/9376	0.382257012393999	PIK3R3	-1.01706486303601
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/112	238/9376	0.351740696278511	PIK3R3	-1.1137995457397
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/112	250/9376	0.334857142857143	GLA	-1.17203364809544
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/112	254/9376	0.329583802024747	VDAC2	-1.19099982993973
NA	NA	hsa04519	Cadherin signaling	2/112	404/9376	0.414427157001414	ACTG1/ACTB	-1.32288579710902
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/112	298/9376	0.280920421860019	LTB	-1.38702846583437