ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0051082 unfolded protein binding 15/153 121/18639 0.12396694214876 15.102090422946 6.60162058919891e-14 2.96412764455031e-11 GO:0031072 heat shock protein binding 12/153 131/18639 0.0916030534351145 11.1594072743601 8.30696784051083e-10 1.86491428019468e-07 GO:0044183 protein folding chaperone 9/153 75/18639 0.12 14.6188235294118 1.05720889824229e-08 1.58228931770262e-06 GO:0031625 ubiquitin protein ligase binding 15/153 302/18639 0.0496688741721854 6.05083755356447 2.93240195514155e-08 2.9187828207882e-06 GO:0140662 ATP-dependent protein folding chaperone 7/153 40/18639 0.175 21.3191176470588 3.25031494519844e-08 2.9187828207882e-06 GO:0044389 ubiquitin-like protein ligase binding 15/153 322/18639 0.046583850931677 5.67500913408842 6.81933996476131e-08 5.10313940696305e-06 GO:0019207 kinase regulator activity 13/153 287/18639 0.0452961672473868 5.51813896290223 7.30064767906556e-07 4.68284401128634e-05 GO:0051087 protein-folding chaperone binding 9/153 134/18639 0.0671641791044776 8.18217734855136 1.62825003434507e-06 9.13855331776172e-05 GO:0045296 cadherin binding 13/153 334/18639 0.0389221556886228 4.74163437830222 3.92067424269842e-06 0.00019559808166351 GO:0005525 GTP binding 13/153 378/18639 0.0343915343915344 4.18969810146281 1.47902394515078e-05 0.000664081751372702 GO:0019001 guanyl nucleotide binding 13/153 400/18639 0.0325 3.95926470588235 2.67497735776105e-05 0.00100088736136226 GO:0032561 guanyl ribonucleotide binding 13/153 400/18639 0.0325 3.95926470588235 2.67497735776105e-05 0.00100088736136226 GO:0003725 double-stranded RNA binding 6/153 75/18639 0.08 9.74588235294118 3.50108555667619e-05 0.00120922108842124 GO:0005200 structural constituent of cytoskeleton 7/153 112/18639 0.0625 7.61397058823529 3.85751056921415e-05 0.0012307177515035 GO:0016887 ATP hydrolysis activity 13/153 417/18639 0.0311750599520384 3.79785583298067 4.11152923664867e-05 0.0012307177515035 GO:0019887 protein kinase regulator activity 10/153 255/18639 0.0392156862745098 4.77739331026528 4.98418318416281e-05 0.00139868640605569 GO:0008135 translation factor activity, RNA binding 6/153 83/18639 0.072289156626506 8.80652019844082 6.21854360655489e-05 0.00142225395131345 GO:0030957 Tat protein binding 3/153 10/18639 0.3 36.5470588235294 6.23889732367721e-05 0.00142225395131345 GO:0023026 MHC class II protein complex binding 4/153 27/18639 0.148148148148148 18.0479302832244 6.61288448597055e-05 0.00142225395131345 GO:0004860 protein kinase inhibitor activity 6/153 84/18639 0.0714285714285714 8.70168067226891 6.65196725558629e-05 0.00142225395131345 GO:0180051 translation factor activity 6/153 84/18639 0.0714285714285714 8.70168067226891 6.65196725558629e-05 0.00142225395131345 GO:0097718 disordered domain specific binding 4/153 28/18639 0.142857142857143 17.4033613445378 7.66594134835326e-05 0.00156454893882301 GO:0019210 kinase inhibitor activity 6/153 90/18639 0.0666666666666667 8.12156862745098 9.78579203814698e-05 0.00191035679353391 GO:0140104 molecular carrier activity 9/153 249/18639 0.036144578313253 4.40326009922041 0.000220092646064081 0.00388278662038351 GO:0004129 cytochrome-c oxidase activity 3/153 15/18639 0.2 24.3647058823529 0.000229526591483981 0.00388278662038351 GO:0140776 protein-containing complex destabilizing activity 3/153 15/18639 0.2 24.3647058823529 0.000229526591483981 0.00388278662038351 GO:0023023 MHC protein complex binding 4/153 37/18639 0.108108108108108 13.1701112877583 0.000233486055123285 0.00388278662038351 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/153 16/18639 0.1875 22.8419117647059 0.000280796412128949 0.00450277103735351 GO:0051787 misfolded protein binding 3/153 17/18639 0.176470588235294 21.4982698961938 0.000338918543550127 0.00524739400186231 GO:0048156 tau protein binding 4/153 43/18639 0.0930232558139535 11.3324213406293 0.000419940207190602 0.00628510510095267 GO:0046332 SMAD binding 5/153 79/18639 0.0632911392405063 7.71034996276992 0.000482594825414969 0.00698984118101035 GO:0003735 structural constituent of ribosome 7/153 175/18639 0.04 4.87294117647059 0.000612300429621732 0.00854568402796129 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/153 48/18639 0.0833333333333333 10.1519607843137 0.000641407215949088 0.00854568402796129 GO:0070182 DNA polymerase binding 3/153 21/18639 0.142857142857143 17.4033613445378 0.000647111930847848 0.00854568402796129 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/153 22/18639 0.136363636363636 16.6122994652406 0.000744794185377581 0.00955464540670097 GO:0003743 translation initiation factor activity 4/153 51/18639 0.0784313725490196 9.55478662053056 0.000808219159286113 0.010080288958874 GO:0140597 protein carrier chaperone 7/153 188/18639 0.0372340425531915 4.53598247809762 0.000933618717502241 0.0113295893015812 GO:0070412 R-SMAD binding 3/153 26/18639 0.115384615384615 14.0565610859729 0.00122758036027702 0.0145048310990627 GO:0000510 H3-H4 histone complex chaperone activity 6/153 151/18639 0.0397350993377483 4.84067004285158 0.00155487035093055 0.0164088994935882 GO:0140584 chromatin extrusion motor activity 6/153 151/18639 0.0397350993377483 4.84067004285158 0.00155487035093055 0.0164088994935882 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 6/153 151/18639 0.0397350993377483 4.84067004285158 0.00155487035093055 0.0164088994935882 GO:0140849 ATP-dependent H2AZ histone chaperone activity 6/153 151/18639 0.0397350993377483 4.84067004285158 0.00155487035093055 0.0164088994935882 GO:0015616 DNA translocase activity 6/153 152/18639 0.0394736842105263 4.80882352941176 0.0016079990595053 0.0164088994935882 GO:0140674 ATP-dependent histone chaperone activity 6/153 152/18639 0.0394736842105263 4.80882352941176 0.0016079990595053 0.0164088994935882 GO:0061775 cohesin loader activity 6/153 153/18639 0.0392156862745098 4.77739331026528 0.00166249804309689 0.0165880360300112 GO:0140097 catalytic activity, acting on DNA 9/153 336/18639 0.0267857142857143 3.26313025210084 0.00185958680291703 0.0181511842284727 GO:0140658 ATP-dependent chromatin remodeler activity 6/153 158/18639 0.0379746835443038 4.62620997766195 0.00195635261285201 0.0186894111312883 GO:0019843 rRNA binding 4/153 65/18639 0.0615384615384615 7.49683257918552 0.00200379199040811 0.0187438042436092 GO:0003689 DNA clamp loader activity 6/153 160/18639 0.0375 4.56838235294118 0.00208429690859056 0.0190989655501461 GO:0004857 enzyme inhibitor activity 10/153 416/18639 0.0240384615384615 2.92845022624434 0.00233009612821793 0.0203529999590903 GO:0140713 histone chaperone activity 6/153 164/18639 0.0365853658536585 4.45695839311334 0.00235905748363352 0.0203529999590903 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/153 68/18639 0.0588235294117647 7.16608996539792 0.00236499655435181 0.0203529999590903 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 9/153 349/18639 0.0257879656160458 3.14158098769594 0.00240246992835587 0.0203529999590903 GO:0140416 transcription regulator inhibitor activity 3/153 33/18639 0.0909090909090909 11.0748663101604 0.00247013664792922 0.0205387287948189 GO:0009055 electron transfer activity 5/153 116/18639 0.0431034482758621 5.25101419878296 0.00269591099129161 0.0220084370016352 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/153 11/18639 0.181818181818182 22.1497326203209 0.00350720072790783 0.0281202344076895 GO:0003724 RNA helicase activity 4/153 77/18639 0.051948051948052 6.32849503437739 0.00371289103323072 0.0292471591915894 GO:0008186 ATP-dependent activity, acting on RNA 4/153 79/18639 0.0506329113924051 6.16827997021593 0.00407066621729144 0.0315125712338596 GO:0005049 nuclear export signal receptor activity 2/153 12/18639 0.166666666666667 20.3039215686275 0.00418603952405487 0.0318564702762819 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/153 13/18639 0.153846153846154 18.7420814479638 0.00492058764907063 0.0362525693241635 GO:0035198 miRNA binding 3/153 42/18639 0.0714285714285714 8.70168067226891 0.00492518202399549 0.0362525693241635 GO:0043176 amine binding 2/153 14/18639 0.142857142857143 17.4033613445378 0.00570989692967149 0.0406943447844841 GO:0098847 sequence-specific single stranded DNA binding 2/153 14/18639 0.142857142857143 17.4033613445378 0.00570989692967149 0.0406943447844841 GO:0003730 mRNA 3'-UTR binding 7/153 262/18639 0.0267175572519084 3.25482712168837 0.00596941627994326 0.041879186088977 GO:0030291 protein serine/threonine kinase inhibitor activity 3/153 46/18639 0.0652173913043478 7.94501278772378 0.006359069678223 0.0439150871896497 GO:0031386 protein tag activity 2/153 15/18639 0.133333333333333 16.243137254902 0.00655303082785418 0.0439150871896497 GO:0141047 molecular tag activity 2/153 15/18639 0.133333333333333 16.243137254902 0.00655303082785418 0.0439150871896497 GO:0001784 phosphotyrosine residue binding 3/153 47/18639 0.0638297872340425 7.77596996245307 0.00675229918248292 0.0443966620543817 GO:0003714 transcription corepressor activity 6/153 204/18639 0.0294117647058824 3.58304498269896 0.0068226496252836 0.0443966620543817 GO:0140297 DNA-binding transcription factor binding 10/153 488/18639 0.0204918032786885 2.49638379942141 0.00710279241414364 0.0455593399135785 GO:0022858 alanine transmembrane transporter activity 2/153 16/18639 0.125 15.2279411764706 0.00744906431581493 0.0471074630676184 GO:0003712 transcription coregulator activity 10/153 495/18639 0.0202020202020202 2.46108140225787 0.00781408260273404 0.0480926969146452 GO:0008094 ATP-dependent activity, acting on DNA 6/153 210/18639 0.0285714285714286 3.48067226890756 0.00781907989926304 0.0480926969146452 GO:0030544 Hsp70 protein binding 3/153 51/18639 0.0588235294117647 7.16608996539792 0.0084680158725594 0.0513802584699888 GO:0003746 translation elongation factor activity 2/153 18/18639 0.111111111111111 13.5359477124183 0.00939618675909411 0.0562518380644434 GO:0140313 molecular sequestering activity 3/153 55/18639 0.0545454545454545 6.64491978609626 0.0104173242898353 0.060909369656682 GO:0097001 ceramide binding 2/153 19/18639 0.105263157894737 12.8235294117647 0.01044548210148 0.060909369656682 GO:0016004 phospholipase activator activity 2/153 20/18639 0.1 12.1823529411765 0.0115440895662489 0.065611344496782 GO:0043024 ribosomal small subunit binding 2/153 20/18639 0.1 12.1823529411765 0.0115440895662489 0.065611344496782 GO:0061980 regulatory RNA binding 3/153 58/18639 0.0517241379310345 6.30121703853955 0.0120360643720972 0.0675524112883953 GO:0036002 pre-mRNA binding 3/153 59/18639 0.0508474576271186 6.19441674975075 0.0126058991329986 0.0681933579604383 GO:0045309 protein phosphorylated amino acid binding 3/153 59/18639 0.0508474576271186 6.19441674975075 0.0126058991329986 0.0681933579604383 GO:0070063 RNA polymerase binding 3/153 59/18639 0.0508474576271186 6.19441674975075 0.0126058991329986 0.0681933579604383 GO:0140517 protein-RNA adaptor activity 2/153 22/18639 0.0909090909090909 11.0748663101604 0.0138857744094878 0.0742227703554765 GO:0043274 phospholipase binding 2/153 23/18639 0.0869565217391304 10.5933503836317 0.0151271454084387 0.0789777707952205 GO:0099186 structural constituent of postsynapse 2/153 23/18639 0.0869565217391304 10.5933503836317 0.0151271454084387 0.0789777707952205 GO:0043021 ribonucleoprotein complex binding 5/153 177/18639 0.0282485875706215 3.44134263875041 0.0154771807569662 0.0798764845962967 GO:0022853 active monoatomic ion transmembrane transporter activity 4/153 118/18639 0.0338983050847458 4.1296111665005 0.0162808931397317 0.0818896952987554 GO:0048027 mRNA 5'-UTR binding 2/153 24/18639 0.0833333333333333 10.1519607843137 0.016414415538726 0.0818896952987554 GO:0060229 lipase activator activity 2/153 24/18639 0.0833333333333333 10.1519607843137 0.016414415538726 0.0818896952987554 GO:0003697 single-stranded DNA binding 4/153 121/18639 0.0330578512396694 4.02722411278561 0.0176900637688793 0.0872839410134811 GO:0015078 proton transmembrane transporter activity 5/153 185/18639 0.027027027027027 3.29252782193959 0.0183818964790889 0.0889580767316322 GO:1990841 promoter-specific chromatin binding 3/153 68/18639 0.0441176470588235 5.37456747404844 0.0184256150023203 0.0889580767316322 GO:0050681 nuclear androgen receptor binding 2/153 26/18639 0.0769230769230769 9.3710407239819 0.0191233560692691 0.0913445412244873 GO:0003924 GTPase activity 7/153 331/18639 0.0211480362537764 2.576328416563 0.0196357180004302 0.0928046040230858 GO:0001671 ATPase activator activity 2/153 27/18639 0.0740740740740741 9.0239651416122 0.0205434036108343 0.0959607913330132 GO:0042826 histone deacetylase binding 4/153 127/18639 0.031496062992126 3.83696155627605 0.0207309504661521 0.0959607913330132 GO:0005518 collagen binding 3/153 72/18639 0.0416666666666667 5.07598039215686 0.021415743141205 0.0981190680653166 GO:0046625 sphingolipid binding 2/153 28/18639 0.0714285714285714 8.70168067226891 0.0220061043435099 0.0988074085023595 GO:0051019 mitogen-activated protein kinase binding 2/153 28/18639 0.0714285714285714 8.70168067226891 0.0220061043435099 0.0988074085023595 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/153 30/18639 0.0666666666666667 8.12156862745098 0.0250563303652372 0.110296983666583 GO:0098918 structural constituent of synapse 2/153 30/18639 0.0666666666666667 8.12156862745098 0.0250563303652372 0.110296983666583 GO:0140142 nucleocytoplasmic carrier activity 2/153 32/18639 0.0625 7.61397058823529 0.0282678623051752 0.123225924029356 GO:0001618 virus receptor activity 3/153 81/18639 0.037037037037037 4.5119825708061 0.0290567045777105 0.125446734186462 GO:0071889 14-3-3 protein binding 2/153 33/18639 0.0606060606060606 7.38324420677362 0.0299322317024169 0.127005764894233 GO:0140272 exogenous protein binding 3/153 82/18639 0.0365853658536585 4.45695839311334 0.0299835436053201 0.127005764894233 GO:0016831 carboxy-lyase activity 2/153 34/18639 0.0588235294117647 7.16608996539792 0.0316346830764044 0.132747408423417 GO:0061631 ubiquitin conjugating enzyme activity 2/153 35/18639 0.0571428571428571 6.96134453781513 0.033374487919171 0.13875134329359 GO:0016209 antioxidant activity 3/153 86/18639 0.0348837209302326 4.24965800273598 0.0338455044444708 0.139418637574013 GO:0003727 single-stranded RNA binding 3/153 89/18639 0.0337078651685393 4.10641110376735 0.0369033158592018 0.150632625643469 GO:0004386 helicase activity 4/153 155/18639 0.0258064516129032 3.1438330170778 0.0390103946576665 0.157798803615246 GO:0051219 phosphoprotein binding 3/153 93/18639 0.032258064516129 3.92979127134725 0.0411932919896823 0.165140965208637 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/153 41/18639 0.0487804878048781 5.94261119081779 0.0445580969091046 0.175496364142 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/153 41/18639 0.0487804878048781 5.94261119081779 0.0445580969091046 0.175496364142 GO:0004520 DNA endonuclease activity 2/153 42/18639 0.0476190476190476 5.80112044817927 0.04653974265336 0.180140900442747 GO:0019894 kinesin binding 2/153 42/18639 0.0476190476190476 5.80112044817927 0.04653974265336 0.180140900442747 GO:0015399 primary active transmembrane transporter activity 4/153 166/18639 0.0240963855421687 2.93550673281361 0.0480839153807842 0.184527162444206 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/153 43/18639 0.0465116279069767 5.66621067031464 0.0485532386286334 0.18474918766319 GO:0005201 extracellular matrix structural constituent 4/153 168/18639 0.0238095238095238 2.90056022408964 0.0498489960601887 0.188085707823737 GO:0001046 core promoter sequence-specific DNA binding 2/153 44/18639 0.0454545454545455 5.53743315508021 0.0505979360678529 0.189320610787216 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/153 45/18639 0.0444444444444444 5.41437908496732 0.0526731945845014 0.193327664838218 GO:0042605 peptide antigen binding 2/153 45/18639 0.0444444444444444 5.41437908496732 0.0526731945845014 0.193327664838218 GO:0004722 protein serine/threonine phosphatase activity 3/153 103/18639 0.029126213592233 3.54825813820674 0.0529605852452134 0.193327664838218 GO:0003713 transcription coactivator activity 5/153 256/18639 0.01953125 2.37936580882353 0.0601852290966319 0.217928773099901 GO:0035254 glutamate receptor binding 2/153 49/18639 0.0408163265306122 4.97238895558223 0.0612673198675775 0.218325608099542 GO:0060590 ATPase regulator activity 2/153 49/18639 0.0408163265306122 4.97238895558223 0.0612673198675775 0.218325608099542 GO:0043022 ribosome binding 3/153 112/18639 0.0267857142857143 3.26313025210084 0.064779134502179 0.22902229442109 GO:0016830 carbon-carbon lyase activity 2/153 51/18639 0.0392156862745098 4.77739331026528 0.065731699532243 0.230574477265446 GO:0015485 cholesterol binding 2/153 54/18639 0.037037037037037 4.5119825708061 0.0726241370217348 0.252777035060147 GO:0005522 profilin binding 1/153 10/18639 0.1 12.1823529411765 0.0791376378967308 0.265170144892777 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/153 10/18639 0.1 12.1823529411765 0.0791376378967308 0.265170144892777 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/153 10/18639 0.1 12.1823529411765 0.0791376378967308 0.265170144892777 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/153 10/18639 0.1 12.1823529411765 0.0791376378967308 0.265170144892777 GO:0098505 G-rich strand telomeric DNA binding 1/153 10/18639 0.1 12.1823529411765 0.0791376378967308 0.265170144892777 GO:0004601 peroxidase activity 2/153 57/18639 0.0350877192982456 4.27450980392157 0.0797380034871191 0.265202693079381 GO:0046982 protein heterodimerization activity 6/153 369/18639 0.016260162601626 1.98087039693926 0.0840013747465815 0.270927832122378 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 2/153 59/18639 0.0338983050847458 4.1296111665005 0.0845962818402627 0.270927832122378 GO:0008199 ferric iron binding 1/153 11/18639 0.0909090909090909 11.0748663101604 0.086700681613613 0.270927832122378 GO:0008432 JUN kinase binding 1/153 11/18639 0.0909090909090909 11.0748663101604 0.086700681613613 0.270927832122378 GO:0015173 aromatic amino acid transmembrane transporter activity 1/153 11/18639 0.0909090909090909 11.0748663101604 0.086700681613613 0.270927832122378 GO:0042608 T cell receptor binding 1/153 11/18639 0.0909090909090909 11.0748663101604 0.086700681613613 0.270927832122378 GO:0050998 nitric-oxide synthase binding 1/153 11/18639 0.0909090909090909 11.0748663101604 0.086700681613613 0.270927832122378 GO:1990948 ubiquitin ligase inhibitor activity 1/153 11/18639 0.0909090909090909 11.0748663101604 0.086700681613613 0.270927832122378 GO:0004519 endonuclease activity 3/153 127/18639 0.0236220472440945 2.87772116720704 0.0868899951572884 0.270927832122378 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 3/153 128/18639 0.0234375 2.85523897058824 0.0884649463828096 0.273936282247459 GO:0005516 calmodulin binding 4/153 207/18639 0.0193236714975845 2.35407786302927 0.091170710237992 0.279359365995685 GO:0015179 L-amino acid transmembrane transporter activity 2/153 62/18639 0.032258064516129 3.92979127134725 0.0920466734849926 0.279359365995685 GO:0003720 telomerase activity 1/153 12/18639 0.0833333333333333 10.1519607843137 0.0942020127126636 0.279359365995685 GO:0035259 nuclear glucocorticoid receptor binding 1/153 12/18639 0.0833333333333333 10.1519607843137 0.0942020127126636 0.279359365995685 GO:0043047 single-stranded telomeric DNA binding 1/153 12/18639 0.0833333333333333 10.1519607843137 0.0942020127126636 0.279359365995685 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/153 12/18639 0.0833333333333333 10.1519607843137 0.0942020127126636 0.279359365995685 GO:0005507 copper ion binding 2/153 63/18639 0.0317460317460317 3.86741363211951 0.0945715448359557 0.279359365995685 GO:0004536 DNA nuclease activity 2/153 64/18639 0.03125 3.80698529411765 0.0971162847904012 0.28500138477706 GO:0140098 catalytic activity, acting on RNA 6/153 387/18639 0.0155038759689922 1.88873689010488 0.0997631107165923 0.290683547956149 GO:0003964 RNA-directed DNA polymerase activity 1/153 13/18639 0.0769230769230769 9.3710407239819 0.101642131467963 0.290683547956149 GO:0005542 folic acid binding 1/153 13/18639 0.0769230769230769 9.3710407239819 0.101642131467963 0.290683547956149 GO:0019104 DNA N-glycosylase activity 1/153 13/18639 0.0769230769230769 9.3710407239819 0.101642131467963 0.290683547956149 GO:0016922 nuclear receptor binding 3/153 137/18639 0.0218978102189781 2.66766852726492 0.103168260253465 0.293180688948137 GO:0032934 sterol binding 2/153 68/18639 0.0294117647058824 3.58304498269896 0.107484209954165 0.303524592889434 GO:0032036 myosin heavy chain binding 1/153 14/18639 0.0714285714285714 8.70168067226891 0.109021534124755 0.304041421254751 GO:1990825 sequence-specific mRNA binding 1/153 14/18639 0.0714285714285714 8.70168067226891 0.109021534124755 0.304041421254751 GO:0019903 protein phosphatase binding 3/153 144/18639 0.0208333333333333 2.53799019607843 0.115227676763429 0.318518171380016 GO:0017081 chloride channel regulator activity 1/153 15/18639 0.0666666666666667 8.12156862745098 0.116340712931676 0.318518171380016 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/153 15/18639 0.0666666666666667 8.12156862745098 0.116340712931676 0.318518171380016 GO:0019209 kinase activator activity 3/153 148/18639 0.0202702702702703 2.46939586645469 0.122347425547077 0.330336131675937 GO:0005159 insulin-like growth factor receptor binding 1/153 16/18639 0.0625 7.61397058823529 0.123600156172734 0.330336131675937 GO:0008142 oxysterol binding 1/153 16/18639 0.0625 7.61397058823529 0.123600156172734 0.330336131675937 GO:0043023 ribosomal large subunit binding 1/153 16/18639 0.0625 7.61397058823529 0.123600156172734 0.330336131675937 GO:0005092 GDP-dissociation inhibitor activity 1/153 17/18639 0.0588235294117647 7.16608996539792 0.130800348199022 0.339476048215959 GO:0008429 phosphatidylethanolamine binding 1/153 17/18639 0.0588235294117647 7.16608996539792 0.130800348199022 0.339476048215959 GO:0016018 cyclosporin A binding 1/153 17/18639 0.0588235294117647 7.16608996539792 0.130800348199022 0.339476048215959 GO:0070402 NADPH binding 1/153 17/18639 0.0588235294117647 7.16608996539792 0.130800348199022 0.339476048215959 GO:1990226 histone methyltransferase binding 1/153 17/18639 0.0588235294117647 7.16608996539792 0.130800348199022 0.339476048215959 GO:0000900 mRNA regulatory element binding translation repressor activity 1/153 18/18639 0.0555555555555556 6.76797385620915 0.137941769460195 0.34144499924125 GO:0008308 voltage-gated monoatomic anion channel activity 1/153 18/18639 0.0555555555555556 6.76797385620915 0.137941769460195 0.34144499924125 GO:0015172 acidic amino acid transmembrane transporter activity 1/153 18/18639 0.0555555555555556 6.76797385620915 0.137941769460195 0.34144499924125 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/153 18/18639 0.0555555555555556 6.76797385620915 0.137941769460195 0.34144499924125 GO:0017128 phospholipid scramblase activity 1/153 18/18639 0.0555555555555556 6.76797385620915 0.137941769460195 0.34144499924125 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/153 18/18639 0.0555555555555556 6.76797385620915 0.137941769460195 0.34144499924125 GO:0015101 organic cation transmembrane transporter activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:0033192 calmodulin-dependent protein phosphatase activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:0140791 histone H2AXS140 phosphatase activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/153 81/18639 0.0246913580246914 3.0079883805374 0.142965834871615 0.34144499924125 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/153 82/18639 0.024390243902439 2.9713055954089 0.145790392153272 0.343068852987956 GO:0033549 MAP kinase phosphatase activity 2/153 82/18639 0.024390243902439 2.9713055954089 0.145790392153272 0.343068852987956 GO:0033218 amide binding 4/153 247/18639 0.0161943319838057 1.97285067873303 0.145937975324498 0.343068852987956 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/153 83/18639 0.0240963855421687 2.93550673281361 0.148626553083357 0.34654420482209 GO:0042277 peptide binding 4/153 249/18639 0.0160642570281124 1.9570044885424 0.148959981137335 0.34654420482209 GO:0017018 myosin phosphatase activity 2/153 84/18639 0.0238095238095238 2.90056022408964 0.151473940542816 0.346550968387697 GO:0051117 ATPase binding 2/153 84/18639 0.0238095238095238 2.90056022408964 0.151473940542816 0.346550968387697 GO:0000339 RNA cap binding 1/153 20/18639 0.05 6.09117647058824 0.152050202165649 0.346550968387697 GO:0042288 MHC class I protein binding 1/153 20/18639 0.05 6.09117647058824 0.152050202165649 0.346550968387697 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/153 21/18639 0.0476190476190476 5.80112044817927 0.159018155281748 0.351719959219237 GO:0001846 opsonin binding 1/153 21/18639 0.0476190476190476 5.80112044817927 0.159018155281748 0.351719959219237 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/153 21/18639 0.0476190476190476 5.80112044817927 0.159018155281748 0.351719959219237 GO:0035613 RNA stem-loop binding 1/153 21/18639 0.0476190476190476 5.80112044817927 0.159018155281748 0.351719959219237 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/153 21/18639 0.0476190476190476 5.80112044817927 0.159018155281748 0.351719959219237 GO:0072542 protein phosphatase activator activity 1/153 21/18639 0.0476190476190476 5.80112044817927 0.159018155281748 0.351719959219237 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 2/153 89/18639 0.0224719101123595 2.73760740251157 0.165866446583451 0.363287973248632 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 2/153 89/18639 0.0224719101123595 2.73760740251157 0.165866446583451 0.363287973248632 GO:0141003 histone H2AX kinase activity 5/153 354/18639 0.0141242937853107 1.72067131937521 0.166704653284573 0.36335140448919 GO:0140793 histone H2AXY142 phosphatase activity 2/153 90/18639 0.0222222222222222 2.70718954248366 0.168773568173987 0.36508793094667 GO:0140996 histone H3 kinase activity 5/153 357/18639 0.0140056022408964 1.70621189652332 0.170742913947013 0.36508793094667 GO:0004602 glutathione peroxidase activity 1/153 23/18639 0.0434782608695652 5.29667519181586 0.172783860838894 0.36508793094667 GO:0005283 amino acid:sodium symporter activity 1/153 23/18639 0.0434782608695652 5.29667519181586 0.172783860838894 0.36508793094667 GO:0016849 phosphorus-oxygen lyase activity 1/153 23/18639 0.0434782608695652 5.29667519181586 0.172783860838894 0.36508793094667 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/153 23/18639 0.0434782608695652 5.29667519181586 0.172783860838894 0.36508793094667 GO:0004721 phosphoprotein phosphatase activity 3/153 175/18639 0.0171428571428571 2.08840336134454 0.174152283767569 0.36508793094667 GO:0043178 alcohol binding 2/153 92/18639 0.0217391304347826 2.64833759590793 0.174613673224482 0.36508793094667 GO:0035173 histone kinase activity 5/153 360/18639 0.0138888888888889 1.69199346405229 0.174819387869786 0.36508793094667 GO:0019957 C-C chemokine binding 1/153 24/18639 0.0416666666666667 5.07598039215686 0.179582532373684 0.371578603851539 GO:0035035 histone acetyltransferase binding 1/153 24/18639 0.0416666666666667 5.07598039215686 0.179582532373684 0.371578603851539 GO:0001848 complement binding 1/153 25/18639 0.04 4.87294117647059 0.186325689641846 0.381776161057939 GO:0019211 phosphatase activator activity 1/153 25/18639 0.04 4.87294117647059 0.186325689641846 0.381776161057939 GO:0004725 protein tyrosine phosphatase activity 2/153 98/18639 0.0204081632653061 2.48619447779112 0.192317287860859 0.381776161057939 GO:0005112 Notch binding 1/153 26/18639 0.0384615384615385 4.68552036199095 0.193013782984748 0.381776161057939 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/153 26/18639 0.0384615384615385 4.68552036199095 0.193013782984748 0.381776161057939 GO:0008143 poly(A) binding 1/153 26/18639 0.0384615384615385 4.68552036199095 0.193013782984748 0.381776161057939 GO:0008198 ferrous iron binding 1/153 26/18639 0.0384615384615385 4.68552036199095 0.193013782984748 0.381776161057939 GO:0043548 phosphatidylinositol 3-kinase binding 1/153 26/18639 0.0384615384615385 4.68552036199095 0.193013782984748 0.381776161057939 GO:0050750 low-density lipoprotein particle receptor binding 1/153 26/18639 0.0384615384615385 4.68552036199095 0.193013782984748 0.381776161057939 GO:0052742 phosphatidylinositol kinase activity 1/153 26/18639 0.0384615384615385 4.68552036199095 0.193013782984748 0.381776161057939 GO:0004364 glutathione transferase activity 1/153 27/18639 0.037037037037037 4.5119825708061 0.199647259114515 0.384727980010374 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/153 27/18639 0.037037037037037 4.5119825708061 0.199647259114515 0.384727980010374 GO:0008266 poly(U) RNA binding 1/153 27/18639 0.037037037037037 4.5119825708061 0.199647259114515 0.384727980010374 GO:0015252 proton channel activity 1/153 27/18639 0.037037037037037 4.5119825708061 0.199647259114515 0.384727980010374 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/153 27/18639 0.037037037037037 4.5119825708061 0.199647259114515 0.384727980010374 GO:0035255 ionotropic glutamate receptor binding 1/153 27/18639 0.037037037037037 4.5119825708061 0.199647259114515 0.384727980010374 GO:0015171 amino acid transmembrane transporter activity 2/153 102/18639 0.0196078431372549 2.38869665513264 0.204247448087179 0.391910701671552 GO:0019902 phosphatase binding 3/153 190/18639 0.0157894736842105 1.92352941176471 0.205204231718508 0.392071064006851 GO:0003785 actin monomer binding 1/153 29/18639 0.0344827586206897 4.20081135902637 0.212752128610972 0.401368511539186 GO:0005416 amino acid:monoatomic cation symporter activity 1/153 29/18639 0.0344827586206897 4.20081135902637 0.212752128610972 0.401368511539186 GO:0051861 glycolipid binding 1/153 29/18639 0.0344827586206897 4.20081135902637 0.212752128610972 0.401368511539186 GO:0008187 poly-pyrimidine tract binding 1/153 30/18639 0.0333333333333333 4.06078431372549 0.219224397515997 0.410132310352845 GO:0031210 phosphatidylcholine binding 1/153 30/18639 0.0333333333333333 4.06078431372549 0.219224397515997 0.410132310352845 GO:0005496 steroid binding 2/153 108/18639 0.0185185185185185 2.25599128540305 0.222287542925566 0.414137372504478 GO:0005164 tumor necrosis factor receptor binding 1/153 31/18639 0.032258064516129 3.92979127134725 0.225643800341514 0.416691335887981 GO:0070325 lipoprotein particle receptor binding 1/153 31/18639 0.032258064516129 3.92979127134725 0.225643800341514 0.416691335887981 GO:0016829 lyase activity 3/153 200/18639 0.015 1.82735294117647 0.226567111157629 0.416691335887981 GO:0001664 G protein-coupled receptor binding 4/153 297/18639 0.0134680134680135 1.64072093483858 0.227777756290699 0.416691335887981 GO:0022884 macromolecule transmembrane transporter activity 1/153 32/18639 0.03125 3.80698529411765 0.232010766084622 0.416691335887981 GO:0031369 translation initiation factor binding 1/153 32/18639 0.03125 3.80698529411765 0.232010766084622 0.416691335887981 GO:0043425 bHLH transcription factor binding 1/153 32/18639 0.03125 3.80698529411765 0.232010766084622 0.416691335887981 GO:0051059 NF-kappaB binding 1/153 32/18639 0.03125 3.80698529411765 0.232010766084622 0.416691335887981 GO:0070717 poly-purine tract binding 1/153 32/18639 0.03125 3.80698529411765 0.232010766084622 0.416691335887981 GO:0019956 chemokine binding 1/153 33/18639 0.0303030303030303 3.69162210338681 0.238325720284066 0.424635906379149 GO:0140311 protein sequestering activity 1/153 33/18639 0.0303030303030303 3.69162210338681 0.238325720284066 0.424635906379149 GO:0035401 histone H3Y41 kinase activity 2/153 115/18639 0.0173913043478261 2.11867007672634 0.243484912610893 0.430412306150752 GO:0140801 histone H2AXY142 kinase activity 2/153 115/18639 0.0173913043478261 2.11867007672634 0.243484912610893 0.430412306150752 GO:0008175 tRNA methyltransferase activity 1/153 34/18639 0.0294117647058824 3.58304498269896 0.244589085047935 0.430668624260873 GO:0004518 nuclease activity 3/153 209/18639 0.0143540669856459 1.74866310160428 0.246144250527872 0.431713939402401 GO:1990782 protein tyrosine kinase binding 2/153 117/18639 0.0170940170940171 2.0824534942182 0.249559882124293 0.433114516567034 GO:0005154 epidermal growth factor receptor binding 1/153 35/18639 0.0285714285714286 3.48067226890756 0.250801279081133 0.433114516567034 GO:0005343 organic acid:sodium symporter activity 1/153 35/18639 0.0285714285714286 3.48067226890756 0.250801279081133 0.433114516567034 GO:0034061 DNA polymerase activity 1/153 35/18639 0.0285714285714286 3.48067226890756 0.250801279081133 0.433114516567034 GO:0000993 RNA polymerase II complex binding 1/153 36/18639 0.0277777777777778 3.38398692810458 0.256962717712642 0.433745339296903 GO:0045505 dynein intermediate chain binding 1/153 36/18639 0.0277777777777778 3.38398692810458 0.256962717712642 0.433745339296903 GO:0055106 ubiquitin-protein transferase regulator activity 1/153 36/18639 0.0277777777777778 3.38398692810458 0.256962717712642 0.433745339296903 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/153 36/18639 0.0277777777777778 3.38398692810458 0.256962717712642 0.433745339296903 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/153 36/18639 0.0277777777777778 3.38398692810458 0.256962717712642 0.433745339296903 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/153 36/18639 0.0277777777777778 3.38398692810458 0.256962717712642 0.433745339296903 GO:0051020 GTPase binding 4/153 315/18639 0.0126984126984127 1.54696545284781 0.259725876404037 0.436767485038998 GO:0022829 wide pore channel activity 1/153 37/18639 0.027027027027027 3.29252782193959 0.263073812922553 0.439108334580766 GO:0043394 proteoglycan binding 1/153 37/18639 0.027027027027027 3.29252782193959 0.263073812922553 0.439108334580766 GO:0042162 telomeric DNA binding 1/153 38/18639 0.0263157894736842 3.20588235294118 0.269134973368894 0.447561492750495 GO:0000217 DNA secondary structure binding 1/153 39/18639 0.0256410256410256 3.1236802413273 0.275146604414245 0.452530495904747 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/153 39/18639 0.0256410256410256 3.1236802413273 0.275146604414245 0.452530495904747 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/153 39/18639 0.0256410256410256 3.1236802413273 0.275146604414245 0.452530495904747 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/153 40/18639 0.025 3.04558823529412 0.281109108152127 0.456621035851285 GO:0050997 quaternary ammonium group binding 1/153 40/18639 0.025 3.04558823529412 0.281109108152127 0.456621035851285 GO:0001530 lipopolysaccharide binding 1/153 41/18639 0.024390243902439 2.9713055954089 0.287022883433203 0.456621035851285 GO:0001727 lipid kinase activity 1/153 41/18639 0.024390243902439 2.9713055954089 0.287022883433203 0.456621035851285 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/153 41/18639 0.024390243902439 2.9713055954089 0.287022883433203 0.456621035851285 GO:0017080 sodium channel regulator activity 1/153 41/18639 0.024390243902439 2.9713055954089 0.287022883433203 0.456621035851285 GO:0042169 SH2 domain binding 1/153 41/18639 0.024390243902439 2.9713055954089 0.287022883433203 0.456621035851285 GO:0042287 MHC protein binding 1/153 41/18639 0.024390243902439 2.9713055954089 0.287022883433203 0.456621035851285 GO:0016798 hydrolase activity, acting on glycosyl bonds 2/153 130/18639 0.0153846153846154 1.87420814479638 0.289088821257916 0.456621035851285 GO:0005085 guanyl-nucleotide exchange factor activity 3/153 230/18639 0.0130434782608696 1.58900255754476 0.292701956030896 0.456621035851285 GO:0008307 structural constituent of muscle 1/153 42/18639 0.0238095238095238 2.90056022408964 0.292888325891248 0.456621035851285 GO:0016859 cis-trans isomerase activity 1/153 42/18639 0.0238095238095238 2.90056022408964 0.292888325891248 0.456621035851285 GO:0031492 nucleosomal DNA binding 1/153 42/18639 0.0238095238095238 2.90056022408964 0.292888325891248 0.456621035851285 GO:0043175 RNA polymerase core enzyme binding 1/153 42/18639 0.0238095238095238 2.90056022408964 0.292888325891248 0.456621035851285 GO:0051879 Hsp90 protein binding 1/153 42/18639 0.0238095238095238 2.90056022408964 0.292888325891248 0.456621035851285 GO:0003954 NADH dehydrogenase activity 1/153 44/18639 0.0227272727272727 2.76871657754011 0.304475778943373 0.459613097956506 GO:0002020 protease binding 2/153 136/18639 0.0147058823529412 1.79152249134948 0.307277713203991 0.459613097956506 GO:0044325 transmembrane transporter binding 2/153 136/18639 0.0147058823529412 1.79152249134948 0.307277713203991 0.459613097956506 GO:0140789 histone phosphatase activity 2/153 136/18639 0.0147058823529412 1.79152249134948 0.307277713203991 0.459613097956506 GO:0140303 intramembrane lipid transporter activity 1/153 45/18639 0.0222222222222222 2.70718954248366 0.310198564951529 0.459613097956506 GO:0030295 protein kinase activator activity 2/153 139/18639 0.0143884892086331 1.75285653829877 0.316341207308217 0.459613097956506 GO:0004713 protein tyrosine kinase activity 2/153 140/18639 0.0142857142857143 1.74033613445378 0.319356696901928 0.459613097956506 GO:0005539 glycosaminoglycan binding 3/153 242/18639 0.012396694214876 1.5102090422946 0.319604966377192 0.459613097956506 GO:0005504 fatty acid binding 1/153 47/18639 0.0212765957446809 2.59198998748436 0.32150417106668 0.459613097956506 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 3/153 243/18639 0.0123456790123457 1.5039941902687 0.321850426607865 0.459613097956506 GO:0022804 active transmembrane transporter activity 5/153 457/18639 0.0109409190371991 1.33286137211996 0.321874897183174 0.459613097956506 GO:0020037 heme binding 2/153 142/18639 0.0140845070422535 1.71582435791218 0.325378232925799 0.459613097956506 GO:0004676 3-phosphoinositide-dependent protein kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0004711 ribosomal protein S6 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0035175 histone H3S10 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0035979 histone H2AXS139 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0044022 histone H3S28 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0044023 histone H4S1 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0044024 histone H2AS1 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0044025 histone H2BS14 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0072354 histone H3T3 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0072371 histone H2AS121 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0072518 Rho-dependent protein serine/threonine kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0140823 histone H2BS36 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0140855 histone H3S57 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0140995 histone H2A kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0140997 histone H4 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0140998 histone H2B kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:1990244 histone H2AT120 kinase activity 3/153 245/18639 0.0122448979591837 1.49171668667467 0.326341789350355 0.459613097956506 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/153 48/18639 0.0208333333333333 2.53799019607843 0.327087747972166 0.459613097956506 GO:0140693 molecular condensate scaffold activity 1/153 48/18639 0.0208333333333333 2.53799019607843 0.327087747972166 0.459613097956506 GO:0004677 DNA-dependent protein kinase activity 3/153 246/18639 0.0121951219512195 1.48565279770445 0.32858753773728 0.459613097956506 GO:0140857 histone H3T45 kinase activity 3/153 246/18639 0.0121951219512195 1.48565279770445 0.32858753773728 0.459613097956506 GO:0035402 histone H3T11 kinase activity 3/153 247/18639 0.0121457489878543 1.47963800904977 0.330833229078421 0.459888915963501 GO:0035403 histone H3T6 kinase activity 3/153 247/18639 0.0121457489878543 1.47963800904977 0.330833229078421 0.459888915963501 GO:0016763 pentosyltransferase activity 1/153 49/18639 0.0204081632653061 2.48619447779112 0.332625673557679 0.460161156140404 GO:0004679 AMP-activated protein kinase activity 3/153 248/18639 0.0120967741935484 1.47367172675522 0.333078787852186 0.460161156140404 GO:0032813 tumor necrosis factor receptor superfamily binding 1/153 50/18639 0.02 2.43647058823529 0.338118318632755 0.465690567687445 GO:0106310 protein serine kinase activity 4/153 361/18639 0.0110803324099723 1.34984520123839 0.344405395594684 0.472899151749276 GO:0005080 protein kinase C binding 1/153 52/18639 0.0192307692307692 2.34276018099548 0.348969235552894 0.477704837692834 GO:0005246 calcium channel regulator activity 1/153 53/18639 0.0188679245283019 2.29855715871254 0.354328234151937 0.481907865582623 GO:0016860 intramolecular oxidoreductase activity 1/153 53/18639 0.0188679245283019 2.29855715871254 0.354328234151937 0.481907865582623 GO:0046906 tetrapyrrole binding 2/153 152/18639 0.0131578947368421 1.60294117647059 0.355259473291422 0.481907865582623 GO:0003925 G protein activity 1/153 54/18639 0.0185185185185185 2.25599128540305 0.359643405795904 0.482029520007047 GO:0017069 snRNA binding 1/153 54/18639 0.0185185185185185 2.25599128540305 0.359643405795904 0.482029520007047 GO:0050661 NADP binding 1/153 54/18639 0.0185185185185185 2.25599128540305 0.359643405795904 0.482029520007047 GO:0051287 NAD binding 1/153 54/18639 0.0185185185185185 2.25599128540305 0.359643405795904 0.482029520007047 GO:0005506 iron ion binding 2/153 154/18639 0.012987012987013 1.58212375859435 0.361182869995551 0.482652109011912 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/153 57/18639 0.0175438596491228 2.13725490196078 0.375329505516099 0.498588603481445 GO:0016504 peptidase activator activity 1/153 57/18639 0.0175438596491228 2.13725490196078 0.375329505516099 0.498588603481445 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1/153 58/18639 0.0172413793103448 2.10040567951318 0.380472901579819 0.503930185278285 GO:0005178 integrin binding 2/153 161/18639 0.0124223602484472 1.51333576909024 0.381751580302849 0.50413664575288 GO:0004879 nuclear receptor activity 1/153 59/18639 0.0169491525423729 2.06480558325025 0.385574222609811 0.504731270996517 GO:0015459 potassium channel regulator activity 1/153 59/18639 0.0169491525423729 2.06480558325025 0.385574222609811 0.504731270996517 GO:0070888 E-box binding 1/153 59/18639 0.0169491525423729 2.06480558325025 0.385574222609811 0.504731270996517 GO:0016791 phosphatase activity 3/153 273/18639 0.010989010989011 1.33872010342599 0.388966369994839 0.505459887427204 GO:0001098 basal transcription machinery binding 1/153 60/18639 0.0166666666666667 2.03039215686274 0.390633810550645 0.505459887427204 GO:0001099 basal RNA polymerase II transcription machinery binding 1/153 60/18639 0.0166666666666667 2.03039215686274 0.390633810550645 0.505459887427204 GO:0098531 ligand-modulated transcription factor activity 1/153 60/18639 0.0166666666666667 2.03039215686274 0.390633810550645 0.505459887427204 GO:0005126 cytokine receptor binding 3/153 275/18639 0.0109090909090909 1.32898395721925 0.393399663743082 0.506121630431644 GO:1901681 sulfur compound binding 3/153 275/18639 0.0109090909090909 1.32898395721925 0.393399663743082 0.506121630431644 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/153 61/18639 0.0163934426229508 1.99710703953713 0.395652004586156 0.507565000169097 GO:0016874 ligase activity 2/153 167/18639 0.0119760479041916 1.45896442409299 0.399158699405981 0.510604718043548 GO:0008201 heparin binding 2/153 172/18639 0.0116279069767442 1.41655266757866 0.413491031426439 0.527436003154748 GO:0003823 antigen binding 2/153 174/18639 0.0114942528735632 1.40027045300879 0.419177090170477 0.53317425916868 GO:0008173 RNA methyltransferase activity 1/153 67/18639 0.0149253731343284 1.81826163301141 0.424910548772464 0.53742207436292 GO:0050840 extracellular matrix binding 1/153 67/18639 0.0149253731343284 1.81826163301141 0.424910548772464 0.53742207436292 GO:0005548 phospholipid transporter activity 1/153 68/18639 0.0147058823529412 1.79152249134948 0.429648255321991 0.541887827639253 GO:0008080 N-acetyltransferase activity 1/153 69/18639 0.0144927536231884 1.76555839727195 0.434347184670747 0.546279792485057 GO:0016853 isomerase activity 2/153 180/18639 0.0111111111111111 1.35359477124183 0.436066250071694 0.546909905816175 GO:0097110 scaffold protein binding 1/153 70/18639 0.0142857142857143 1.74033613445378 0.439007652131456 0.549065280799509 GO:0004521 RNA endonuclease activity 1/153 73/18639 0.0136986301369863 1.66881547139404 0.452761398228694 0.563129827713805 GO:0043539 protein serine/threonine kinase activator activity 1/153 73/18639 0.0136986301369863 1.66881547139404 0.452761398228694 0.563129827713805 GO:0031406 carboxylic acid binding 2/153 187/18639 0.0106951871657754 1.30292544825417 0.455433610036134 0.563377771838762 GO:0003684 damaged DNA binding 1/153 74/18639 0.0135135135135135 1.64626391096979 0.457271120628296 0.563377771838762 GO:0031491 nucleosome binding 1/153 74/18639 0.0135135135135135 1.64626391096979 0.457271120628296 0.563377771838762 GO:0046943 carboxylic acid transmembrane transporter activity 2/153 188/18639 0.0106382978723404 1.29599499374218 0.458169567380564 0.563377771838762 GO:0005342 organic acid transmembrane transporter activity 2/153 189/18639 0.0105820105820106 1.28913787737317 0.460897645144498 0.563377771838762 GO:0043177 organic acid binding 2/153 189/18639 0.0105820105820106 1.28913787737317 0.460897645144498 0.563377771838762 GO:0019003 GDP binding 1/153 75/18639 0.0133333333333333 1.6243137254902 0.461743919903484 0.563377771838762 GO:0017022 myosin binding 1/153 76/18639 0.0131578947368421 1.60294117647059 0.466180096387796 0.567248951973226 GO:0051540 metal cluster binding 1/153 77/18639 0.012987012987013 1.58212375859435 0.470579947987897 0.571055126071799 GO:0004674 protein serine/threonine kinase activity 4/153 433/18639 0.0092378752886836 1.12539057193316 0.476909823073984 0.576925102972861 GO:0015370 solute:sodium symporter activity 1/153 79/18639 0.0126582278481013 1.54206999255398 0.479271856144492 0.576925102972861 GO:0033293 monocarboxylic acid binding 1/153 79/18639 0.0126582278481013 1.54206999255398 0.479271856144492 0.576925102972861 GO:0000049 tRNA binding 1/153 80/18639 0.0125 1.52279411764706 0.483564496554508 0.578987890541265 GO:0048306 calcium-dependent protein binding 1/153 80/18639 0.0125 1.52279411764706 0.483564496554508 0.578987890541265 GO:0030971 receptor tyrosine kinase binding 1/153 81/18639 0.0123456790123457 1.5039941902687 0.487821979825544 0.582532098249121 GO:0004842 ubiquitin-protein transferase activity 4/153 449/18639 0.0089086859688196 1.08528756714267 0.5051772943712 0.601656777646336 GO:0016651 oxidoreductase activity, acting on NAD(P)H 1/153 88/18639 0.0113636363636364 1.38435828877005 0.516663702969533 0.613709001675451 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 1/153 91/18639 0.010989010989011 1.33872010342599 0.528524973390647 0.624493981716843 GO:0072341 modified amino acid binding 1/153 91/18639 0.010989010989011 1.33872010342599 0.528524973390647 0.624493981716843 GO:0016410 N-acyltransferase activity 1/153 94/18639 0.0106382978723404 1.29599499374218 0.540097019395651 0.634826077771328 GO:0042562 hormone binding 1/153 94/18639 0.0106382978723404 1.29599499374218 0.540097019395651 0.634826077771328 GO:0016407 acetyltransferase activity 1/153 96/18639 0.0104166666666667 1.26899509803922 0.547654503811445 0.642028386974775 GO:0019787 ubiquitin-like protein transferase activity 4/153 479/18639 0.00835073068893528 1.01731548569323 0.556280915045398 0.64880404885226 GO:0061630 ubiquitin protein ligase activity 3/153 353/18639 0.0084985835694051 1.03532744542576 0.556324184427884 0.64880404885226 GO:0045182 translation regulator activity 3/153 356/18639 0.00842696629213483 1.02660277594184 0.562077492522068 0.65159015484184 GO:0043130 ubiquitin binding 1/153 100/18639 0.01 1.21823529411765 0.562401298118069 0.65159015484184 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/153 229/18639 0.00873362445414847 1.06396095556126 0.563066770776468 0.65159015484184 GO:0030695 GTPase regulator activity 4/153 489/18639 0.0081799591002045 0.996511488030795 0.572691206163742 0.65898416817276 GO:0005253 monoatomic anion channel activity 1/153 103/18639 0.00970873786407767 1.18275271273558 0.57314704317922 0.65898416817276 GO:0060589 nucleoside-triphosphatase regulator activity 4/153 490/18639 0.00816326530612245 0.994477791116447 0.574313811404005 0.65898416817276 GO:0042578 phosphoric ester hydrolase activity 3/153 363/18639 0.00826446280991736 1.0068060281964 0.575326935242142 0.65898416817276 GO:0016755 aminoacyltransferase activity 4/153 496/18639 0.00806451612903226 0.982447817836812 0.583977400371889 0.667190465055924 GO:0019888 protein phosphatase regulator activity 1/153 107/18639 0.00934579439252336 1.13853765805388 0.587067952482497 0.669019062600612 GO:0061659 ubiquitin-like protein ligase activity 3/153 372/18639 0.00806451612903226 0.982447817836812 0.591994584981276 0.672925490269855 GO:0042393 histone binding 2/153 247/18639 0.00809716599190283 0.986425339366516 0.604345261973059 0.685229855115918 GO:0001221 transcription coregulator binding 1/153 115/18639 0.00869565217391304 1.05933503836317 0.613570907067237 0.693937877262442 GO:0015294 solute:monoatomic cation symporter activity 1/153 116/18639 0.00862068965517241 1.05020283975659 0.616762639480254 0.695795038006618 GO:0019208 phosphatase regulator activity 1/153 117/18639 0.00854700854700855 1.0412267471091 0.619928180491943 0.697613416142562 GO:0032182 ubiquitin-like protein binding 1/153 120/18639 0.00833333333333333 1.01519607843137 0.629269781731815 0.706355329993963 GO:0004540 RNA nuclease activity 1/153 121/18639 0.00826446280991736 1.0068060281964 0.632332675159918 0.707894099297798 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/153 122/18639 0.00819672131147541 0.998553519768563 0.635370427654816 0.707894099297798 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/153 122/18639 0.00819672131147541 0.998553519768563 0.635370427654816 0.707894099297798 GO:0008514 organic anion transmembrane transporter activity 2/153 269/18639 0.00743494423791822 0.90575114804286 0.650734736210261 0.723217565738631 GO:0031490 chromatin DNA binding 1/153 128/18639 0.0078125 0.951746323529412 0.653080348407467 0.724032287493711 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/153 132/18639 0.00757575757575758 0.922905525846702 0.664409493157586 0.734777986275262 GO:0030246 carbohydrate binding 2/153 280/18639 0.00714285714285714 0.870168067226891 0.672273015690201 0.741647626645947 GO:0016779 nucleotidyltransferase activity 1/153 136/18639 0.00735294117647059 0.895761245674741 0.675371008325198 0.743239173377485 GO:0031267 small GTPase binding 2/153 283/18639 0.00706713780918728 0.860943670754521 0.677958608766669 0.744262629183948 GO:0070851 growth factor receptor binding 1/153 139/18639 0.00719424460431655 0.876428269149386 0.683358032858543 0.744727564935645 GO:0140101 catalytic activity, acting on a tRNA 1/153 139/18639 0.00719424460431655 0.876428269149386 0.683358032858543 0.744727564935645 GO:0140767 enzyme-substrate adaptor activity 1/153 139/18639 0.00719424460431655 0.876428269149386 0.683358032858543 0.744727564935645 GO:0019955 cytokine binding 1/153 144/18639 0.00694444444444444 0.845996732026144 0.696238184545184 0.75692722726583 GO:0015293 symporter activity 1/153 146/18639 0.00684931506849315 0.834407735697019 0.701243274483726 0.760527126191288 GO:0008509 monoatomic anion transmembrane transporter activity 1/153 149/18639 0.00671140939597315 0.81760757994473 0.708597691480209 0.766651478252082 GO:0019842 vitamin binding 1/153 150/18639 0.00666666666666667 0.812156862745098 0.711008970723234 0.767411124650798 GO:0140375 immune receptor activity 1/153 156/18639 0.00641025641025641 0.780920060331825 0.725065976208786 0.780706530737997 GO:0099106 ion channel regulator activity 1/153 160/18639 0.00625 0.761397058823529 0.734057763272337 0.788497453849951 GO:0015081 sodium ion transmembrane transporter activity 1/153 164/18639 0.00609756097560976 0.742826398852224 0.742757331114124 0.795938046945684 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/153 167/18639 0.00598802395209581 0.729482212046495 0.749095926081411 0.800819216215603 GO:0016247 channel regulator activity 1/153 168/18639 0.00595238095238095 0.725140056022409 0.751174115953084 0.801133439579417 GO:0141108 transporter regulator activity 1/153 170/18639 0.00588235294117647 0.716608996539792 0.7552793305137 0.801892904355356 GO:0030371 translation repressor activity 2/153 329/18639 0.0060790273556231 0.740568567852673 0.755458125929433 0.801892904355356 GO:0005244 voltage-gated monoatomic ion channel activity 1/153 173/18639 0.00578034682080925 0.704182250935056 0.761311319619184 0.806037604831144 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 3/153 484/18639 0.00619834710743802 0.755104521147302 0.762953189428143 0.806037604831144 GO:0022832 voltage-gated channel activity 1/153 175/18639 0.00571428571428571 0.696134453781513 0.765250348993822 0.806566682390202 GO:0005319 lipid transporter activity 1/153 178/18639 0.00561797752808989 0.684401850627892 0.77103812174488 0.809270388240308 GO:0001216 DNA-binding transcription activator activity 3/153 491/18639 0.00610997963340122 0.744339283574937 0.771420325538645 0.809270388240308 GO:0005543 phospholipid binding 3/153 497/18639 0.00603621730382294 0.735353296248077 0.778481667663919 0.814774519303262 GO:0008168 methyltransferase activity 1/153 204/18639 0.00490196078431373 0.59717416378316 0.815614424382435 0.851653201273752 GO:0051015 actin filament binding 1/153 209/18639 0.00478468899521531 0.582887700534759 0.823140747604087 0.857517855392657 GO:0015631 tubulin binding 2/153 385/18639 0.00519480519480519 0.632849503437739 0.827741937317483 0.860315115406366 GO:0016741 transferase activity, transferring one-carbon groups 1/153 215/18639 0.00465116279069767 0.566621067031464 0.831770449295684 0.862505616013307 GO:0061134 peptidase regulator activity 1/153 226/18639 0.00442477876106195 0.539042165538782 0.846519309805562 0.875776889637551 GO:0000287 magnesium ion binding 1/153 230/18639 0.00434782608695652 0.529667519181586 0.851557781016434 0.878964238336503 GO:0005125 cytokine activity 1/153 234/18639 0.00427350427350427 0.52061337355455 0.856431894771361 0.881967708147572 GO:0003779 actin binding 2/153 443/18639 0.00451467268623025 0.549993360775461 0.881887475856689 0.90610406558273 GO:0005216 monoatomic ion channel activity 2/153 448/18639 0.00446428571428571 0.543855042016807 0.885736550924327 0.907981076175852 GO:0016757 glycosyltransferase activity 1/153 267/18639 0.00374531835205993 0.456267900418594 0.891027611403123 0.910179248982756 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 1/153 268/18639 0.00373134328358209 0.454565408252853 0.891935121497578 0.910179248982756 GO:0005096 GTPase activator activity 1/153 271/18639 0.003690036900369 0.4495333188626 0.89461284621839 0.910841650684937 GO:0008017 microtubule binding 1/153 276/18639 0.0036231884057971 0.441389599317988 0.898930012144768 0.912805106837137 GO:0001217 DNA-binding transcription repressor activity 1/153 278/18639 0.00359712230215827 0.438214134574693 0.900607265765817 0.912805106837137 GO:0035091 phosphatidylinositol binding 1/153 284/18639 0.00352112676056338 0.428956089478045 0.905474901043217 0.915671690469379 GO:0015291 secondary active transmembrane transporter activity 1/153 287/18639 0.00348432055749129 0.424472227915556 0.907819150187456 0.915979322323973 GO:0022836 gated channel activity 1/153 318/18639 0.00314465408805031 0.383092859785424 0.92890550885227 0.935153752185356 GO:0005261 monoatomic cation channel activity 1/153 341/18639 0.00293255131964809 0.357253751940659 0.941383730898387 0.945595738642899 GO:0004175 endopeptidase activity 1/153 405/18639 0.00246913580246914 0.30079883805374 0.965784087906904 0.967939855960268 GO:0046873 metal ion transmembrane transporter activity 1/153 450/18639 0.00222222222222222 0.270718954248366 0.976592740320931 0.976592740320931