category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	42/168	222/9376	10.5585585585586	RPL14/RPL8/RPL39/RPL9/RPL18/RPS3/RPS7/RPL7A/RPS3A/RPS24/RPS4X/RPL5/RPL11/RPL19/RPS6/RPL24/RPS2/RPL13/RPL15/RPL10/RPL7/RPS28/RPL3/RACK1/RPS5/RPL18A/RPL36AL/RPS23/RPS25/RPSA/RSL24D1/MRPS6/RPS13/RPS27/RPS27L/RPL12/RPS9/RPL10A/RPL13A/RPS15A/RPS14/RPL36	19.4679876491127
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	43/168	238/9376	10.0832332933173	C7/RPL14/RPL8/RPL39/RPL9/RPL18/RPS3/RPS7/RPL7A/RPS3A/RPS24/RPS4X/RPL5/RPL11/RPL19/RPS6/RPL24/RPS2/IL6ST/RPL13/RPL15/RPL10/RPL7/RPS28/RPL3/RPS5/RPL18A/RPL36AL/RPS23/RPS25/RPSA/RSL24D1/RPS13/RPS27/RPS27L/RPL12/RPS9/RPL10A/RPL13A/RPS15A/RPS14/RPL36/CFD	19.1717163178026
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/168	42/9376	7.97278911564626	FTL/FTH1/SLC3A2/SLC40A1/PCBP1/GPX4	6.1172312902237
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/168	95/9376	3.52481203007519	CTSL/IL18/ATP6V0C/ATP6V0E1/ACP5/CCL20	3.34080472248542
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	10/168	250/9376	2.23238095238095	CTSL/NPC2/ATP6V0C/ATP6V0E1/VAMP8/NEU1/LAPTM4A/ACP5/CLTC/TPP1	2.66767164800529
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/168	32/9376	5.23214285714286	GABARAP/GABARAPL1/IGBP1	3.23911611698172
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/168	187/9376	2.38757321110262	TXNIP/IL18/GABARAP/PLCB1/HSP90AB1/IFI16/ANTXR2/GABARAPL1	2.5888101810455
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/168	61/9376	3.65964090554255	FTL/FTH1/SLC40A1/CYBRD1	2.81484260272253
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/168	63/9376	3.54346182917611	PTGES3/PTGDS/GPX4/PTGES	2.73595103987835
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/168	37/9376	4.52509652509652	IL18/PLCB1/HBA2	2.90187907943179
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/168	73/9376	3.05805609915199	GADD45G/PDGFRA/PDGFD/MET	2.38432115479862
NA	NA	hsa04081	Hormone signaling	8/168	219/9376	2.03870406610133	GNGT1/VIPR2/RAMP1/THRB/SLC40A1/PLCB1/AGT/PRLR	2.10084932643474
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/168	80/9376	2.79047619047619	RPS6/PDGFRA/PDGFD/MET	2.17231654495768
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/168	82/9376	2.72241579558653	CTSL/HLA-A/HSP90AB1/B2M	2.11592960702218
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/168	50/9376	3.34857142857143	IL18/MET/HBA2	2.24904784021478
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/168	88/9376	2.53679653679654	C7/CLU/SERPING1/CFD	1.95638457333987
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/168	204/9376	1.91503267973856	CTSL/RPS6/EIF4B/DCN/PPP1CB/TWIST1/MET	1.78474958356384
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/168	89/9376	2.50829320492242	GJA1/PLCB1/PDGFRA/PDGFD	1.93108183579607
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/168	89/9376	2.50829320492242	GNGT1/GABARAP/GABARAPL1/TRAK2	1.93108183579607
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/168	56/9376	2.98979591836735	IL18/EEF1A1/EEF1G	2.01721512929996
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/168	28/9376	3.98639455782313	ATP6V0C/ATP6V0E1	2.1375903148012
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/168	106/9376	2.10601976639712	TCF7L2/HSP90AB1/PDGFRA/PDGFD	1.54679791468927
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/168	69/9376	2.42650103519669	PLCB1/PDE1C/AGT	1.60638412398173
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/168	71/9376	2.35814889336016	ATP6V0C/ATP6V0E1/MET	1.55158650438896
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/168	37/9376	3.01673101673102	TCF7L2/GADD45G	1.66018419768879
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/168	73/9376	2.29354207436399	BST2/SERINC3/TSG101	1.49860819333302
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	5/168	155/9376	1.80030721966206	CTSL/HLA-A/ATP6V0C/ATP6V0E1/COLEC12	1.35703546131891
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/168	75/9376	2.23238095238095	IGFBP3/GADD45G/SESN1	1.44733282052627
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/168	75/9376	2.23238095238095	GPX3/PLCB1/SLC26A4	1.44733282052627
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/168	158/9376	1.76612417118746	STAG2/GADD45G/SKP1/CDKN1C/SMC3	1.31179804661955
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/168	79/9376	2.11934900542495	ATP6V0C/ATP6V0E1/CLTC	1.34947633080346
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/168	254/9376	1.53805774278215	EDNRB/VEGFC/PLCB1/PDE1C/PDGFRA/PDGFD/MET	1.1742439560102
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	6/168	214/9376	1.56475300400534	GNGT1/HLA-A/BST2/B2M/CFL2/SKP1	1.12882837181921
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/168	83/9376	2.01721170395869	IL18/PCBP1/IFI16	1.25727433371073
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/168	169/9376	1.65116934347704	CTSL/GABARAP/GABARAPL1/VAMP8/IGBP1	1.15381412320409
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/168	46/9376	2.42650103519669	FTL/FTH1	1.30998948256568
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/168	86/9376	1.9468438538206	TCF7L2/GJA1/SGCA	1.19145421166113
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	9/168	362/9376	1.38752959747435	GNGT1/RPS6/VEGFC/EIF4B/HSP90AB1/PDGFRA/PDGFD/MET/PRLR	1.01568259279586
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/168	130/9376	1.71721611721612	GNGT1/EDNRB/VEGFC/PLCB1	1.11224995226359
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/168	47/9376	2.37487335359676	ACSS1/ADH1B	1.27629686118587
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/168	178/9376	1.56768325307651	FRZB/TCF7L2/RSPO2/PLCB1/SKP1	1.03282562576349
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/168	133/9376	1.67848191908342	GABARAP/GADD45G/DEPP1/GABARAPL1	1.06442544143161
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/168	134/9376	1.66595593461265	RAMP1/PLCB1/PPP1CB/AGT	1.04875135341818
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/168	51/9376	2.18860877684407	ATP6V0C/ATP6V0E1	1.14962771299768
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/168	93/9376	1.80030721966206	TCF7L2/ARHGAP29/MET	1.04763900045411
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/168	53/9376	2.10601976639712	PLCB1/CLTC	1.0906379491199
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/168	17/9376	3.28291316526611	CA8	1.27249695985892
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/168	100/9376	1.67428571428571	IL18/IL6ST/CCL20	0.915632527425513
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/168	101/9376	1.65770862800566	TCF7L2/EDNRB/PLCB1	0.897624898429542
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/168	101/9376	1.65770862800566	VEGFC/PLCB1/AGT	0.897624898429542
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/168	149/9376	1.4982422499201	PLCB1/AGT/PDGFRA/PDGFD	0.828058557476481
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/168	18/9376	3.1005291005291	NEU1	1.20484466363026
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/168	18/9376	3.1005291005291	PRDX1	1.20484466363026
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/168	59/9376	1.89184826472962	GPX3/GPX4	0.928189291089326
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/168	59/9376	1.89184826472962	TCF7L2/GADD45G	0.928189291089326
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/168	105/9376	1.59455782312925	GABARAP/TOMM20/GABARAPL1	0.827528730313201
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/168	201/9376	1.38829661217721	NUPR1/IGFBP3/GADD45G/MAF/MET	0.751650961629945
NA	NA	hsa04518	Integrin signaling	4/168	154/9376	1.44959802102659	VEGFC/PDGFRA/PDGFD/MET	0.759853408924602
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/168	203/9376	1.37461881304246	VEGFC/PPP1CB/PDGFRA/PDGFD/MET	0.728852301418979
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	5/168	205/9376	1.36120789779326	PDK4/PLCB1/PPP1CB/AGT/COX7A2L	0.706290630659675
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/168	157/9376	1.42189869578405	HLA-A/IGFBP3/GADD45G/PPP1CB	0.720068355017973
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/168	109/9376	1.53604193971166	OGA/PPP1CB/AGT	0.760326384196329
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/168	63/9376	1.77173091458806	TCF7L2/GADD45G	0.830135516111678
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/168	158/9376	1.41289933694997	RPS6/SLC3A2/EIF4B/FNIP1	0.706987932285122
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/168	110/9376	1.52207792207792	DCN/SKP1/IGSF1	0.743948969114935
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/168	65/9376	1.71721611721612	PLCB1/AGT	0.783729472970744
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	5/168	212/9376	1.3162623539982	VEGFC/PLCB1/PDGFRA/PDGFD/MET	0.629115685041352
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/168	66/9376	1.69119769119769	IL18/MAF	0.761126827518229
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/168	67/9376	1.66595593461265	ACSS1/ADH1B	0.738905677263077
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/168	67/9376	1.66595593461265	PLCB1/PPP1CB	0.738905677263077
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/168	23/9376	2.42650103519669	AGT	0.925162808311992
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/168	370/9376	1.20669240669241	VIPR2/EDNRB/THRB/PTH2R/SPX/NPW/AGT/PRLR	0.547919852908679
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/168	116/9376	1.44334975369458	GNGT1/PLCB1/DLGAP1	0.648974446270656
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/168	70/9376	1.59455782312925	HLA-A/SGCA	0.67440257143795
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/168	71/9376	1.57209926224011	PDGFRA/MET	0.65358187073767
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/168	26/9376	2.14652014652015	SLC19A3	0.790715373769012
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/168	73/9376	1.52902804957599	GADD45G/MET	0.612895231867411
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/168	227/9376	1.22928466540801	GNGT1/HLA-A/PLCB1/B2M/PDGFRA	0.472344375790241
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/168	27/9376	2.06701940035273	ELOVL2	0.749944702537229
Organismal Systems	Immune system	hsa04611	Platelet activation	3/168	126/9376	1.32879818594104	PLCB1/PPP1CB/VAMP8	0.50188179513108
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/168	76/9376	1.468671679198	GADD45G/PDGFRA	0.554104473581048
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/168	28/9376	1.99319727891156	ELOVL2	0.710907029523862
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/168	28/9376	1.99319727891156	DHFR	0.710907029523862
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/168	232/9376	1.20279146141215	C7/PPP1CB/CFL2/PDGFRA/PDGFD	0.422457643776934
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/168	180/9376	1.24021164021164	HLA-A/BST2/B2M/PPP1CB	0.439529919659247
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/168	29/9376	1.92446633825944	GNGT1	0.673459686091649
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/168	78/9376	1.43101343101343	MET/CLTC	0.516298612350805
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/168	78/9376	1.43101343101343	CFL2/SERPING1	0.516298612350805
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/168	30/9376	1.86031746031746	DHFR	0.637476383054397
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/168	238/9376	1.17246898759504	GNGT1/VEGFC/PDGFRA/PDGFD/MET	0.364025275693772
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/168	133/9376	1.25886143931257	GNGT1/PLCB1/PPP1CB	0.406110603775754
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/168	31/9376	1.80030721966206	ACSS1	0.602844846366755
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/168	31/9376	1.80030721966206	IMMP2L	0.602844846366755
NA	NA	hsa04981	Folate transport and metabolism	1/168	31/9376	1.80030721966206	DHFR	0.602844846366755
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/168	32/9376	1.74404761904762	ACSS1	0.569464858822384
Human Diseases	Immune disease	hsa05310	Asthma	1/168	32/9376	1.74404761904762	PRG2	0.569464858822384
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/168	33/9376	1.69119769119769	VAMP8	0.537246627658685
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/168	138/9376	1.21325051759834	ATP6V0C/ATP6V0E1/COX7A2L	0.34087745751201
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/168	138/9376	1.21325051759834	PPP1CB/SKP1/SMC3	0.34087745751201
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/168	138/9376	1.21325051759834	RPS6/PPP1CB/PRKAR2B	0.34087745751201
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/168	139/9376	1.20452209660843	PLCB1/HSP90AB1/KRT18	0.328125353182079
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/168	86/9376	1.29789590254707	PLCB1/PDE1C	0.374855184721455
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	5/168	248/9376	1.12519201228879	RPS3/IL18/TCF7L2/HSP90AB1/SKP1	0.269880973861786
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/168	34/9376	1.64145658263305	SKP1	0.50610941569033
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/168	140/9376	1.19591836734694	GNGT1/RPS6/PLCB1	0.31546765134591
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/168	87/9376	1.28297755883963	TCF7L2/GADD45G	0.35816633616914
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/168	250/9376	1.11619047619048	HLA-A/SNX2/PDGFRA/CLTC/TSG101	0.251511546411627
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	4/168	196/9376	1.13896987366375	GNGT1/HLA-A/TCF7L2/IL6ST	0.2655736494138
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/168	36/9376	1.55026455026455	GALNT15	0.446793628411813
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/168	91/9376	1.22658294086866	GNGT1/PDE1C	0.293369239596847
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/168	37/9376	1.50836550836551	ADH1B	0.418489315945803
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/168	38/9376	1.468671679198	NAPRT	0.391013001349068
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/168	93/9376	1.20020481310804	MAF/RBPJ	0.262077318731642
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/168	205/9376	1.08896631823461	HLA-A/GADD45G/B2M/RBPJ	0.173960972053155
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/168	205/9376	1.08896631823461	HLA-A/IL6ST/HDAC9/RBPJ	0.173960972053155
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/168	94/9376	1.18743667679838	HSP90AB1/CCL20	0.246692158085773
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/168	150/9376	1.11619047619048	TCF7L2/GADD45G/MET	0.193761308982724
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/168	39/9376	1.43101343101343	DHFR	0.364314998827837
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/168	39/9376	1.43101343101343	HLA-A	0.364314998827837
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/168	97/9376	1.1507118311242	GNGT1/PLCB1	0.201530252952213
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/168	154/9376	1.08719851576994	PLCB1/PPP1CB/AGT	0.147371844096794
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/168	98/9376	1.13896987366375	PLCB1/AGT	0.186794523891214
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/168	155/9376	1.08018433179724	TCF7L2/PLCB1/AGT	0.135964013590877
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/168	99/9376	1.12746512746513	PLCB1/PPP1CB	0.172211768770119
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/168	99/9376	1.12746512746513	KRT18/CFD	0.172211768770119
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/168	99/9376	1.12746512746513	PDGFRA/PDGFD	0.172211768770119
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/168	99/9376	1.12746512746513	AGT/SGCA	0.172211768770119
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/168	43/9376	1.29789590254707	ADH1B	0.264451325595702
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/168	44/9376	1.26839826839827	MBD4	0.241032889181905
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/168	44/9376	1.26839826839827	HLA-A	0.241032889181905
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/168	103/9376	1.08368007397134	SLC15A1/SLC3A2	0.115342181647023
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/168	103/9376	1.08368007397134	PLCB1/PRDX1	0.115342181647023
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/168	45/9376	1.24021164021164	HLA-A	0.218169398670658
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/168	105/9376	1.06303854875283	AGT/SGCA	0.0877395068753127
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/168	166/9376	1.00860585197935	EDNRB/PLCB1/PPP1CB	0.0151103917734319
NA	NA	hsa03272	Virion - Hepatitis viruses	1/168	48/9376	1.16269841269841	TSG101	0.152639624743253
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/168	48/9376	1.16269841269841	PLCB1	0.152639624743253
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/168	168/9376	0.996598639455782	FTL/FTH1/HSP90AB1	-0.00600872431768554
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/168	168/9376	0.996598639455782	IL6ST/PDGFRA/PRLR	-0.00600872431768554
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/168	109/9376	1.02402795980778	IL6ST/HSP90AB1	0.0340814597643016
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/168	49/9376	1.13896987366375	GALNT15	0.131736262563844
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	3/168	170/9376	0.984873949579832	TCF7L2/GADD45G/MET	-0.0268826540303596
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	4/168	233/9376	0.958103413039035	TMOD1/DCN/FMNL2/SGCA	-0.0874721637739345
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/168	174/9376	0.962233169129721	HSP90AB1/CRYAB/SKP1	-0.0679206255031502
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/168	52/9376	1.07326007326007	NPC2	0.0715526152347575
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/168	115/9376	0.970600414078675	GNGT1/PLCB1	-0.0428468417461446
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/168	115/9376	0.970600414078675	GNGT1/PLCB1	-0.0428468417461446
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/168	115/9376	0.970600414078675	NACA/PLCB1	-0.0428468417461446
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/168	54/9376	1.03350970017637	HLA-A	0.0333557335844223
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/168	300/9376	0.93015873015873	VEGFC/GADD45G/PDGFRA/PDGFD/MET	-0.16606692135553
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/168	55/9376	1.01471861471861	NEU1	0.0147868154179418
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/168	119/9376	0.93797519007603	VEGFC/CCL20	-0.0919732249012694
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/168	57/9376	0.979114452798663	ELOVL2	-0.0213627055252256
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/168	184/9376	0.909937888198758	SEMA6D/CFL2/MET	-0.166649361336885
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/168	122/9376	0.914910226385636	THRB/PLCB1	-0.127776256317248
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/168	122/9376	0.914910226385636	IGFBP3/PLCB1	-0.127776256317248
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/168	60/9376	0.93015873015873	PLCB1	-0.0733045000362123
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/168	253/9376	0.882364012798795	IL18/PLCB1/SKP1/TIFA	-0.256205971813893
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/168	191/9376	0.87658937920718	GNGT1/HDAC9/PPP1CB	-0.232748700034918
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/168	62/9376	0.900153609831029	CRYAB	-0.10654123329839
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/168	62/9376	0.900153609831029	RBPJ	-0.10654123329839
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/168	193/9376	0.867505551443375	GNGT1/PLCB1/CCL20	-0.25121274441128
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/168	65/9376	0.858608058608059	PLCB1	-0.154504380269003
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/168	66/9376	0.845598845598846	HSD17B11	-0.170022067942485
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/168	136/9376	0.820728291316527	RACK1/EIF3H	-0.284447977520969
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/168	137/9376	0.814737573861661	CTSL/GADD45G	-0.295048065095595
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/168	68/9376	0.820728291316527	ADH1B	-0.200399046428628
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/168	68/9376	0.820728291316527	TCF7L2	-0.200399046428628
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/168	69/9376	0.808833678398896	PPP1CB	-0.215272570073991
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	5/168	333/9376	0.837980837980838	HLA-A/TCF7L2/ATP6V0C/ATP6V0E1/RBPJ	-0.40662104927217
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/168	70/9376	0.797278911564626	MET	-0.229945041520033
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/168	71/9376	0.786049631120054	PRLR	-0.244422762913619
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/168	142/9376	0.786049631120054	UBE2B/SKP1	-0.346992350206513
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	2/168	142/9376	0.786049631120054	CTSL/HSP90AB1	-0.346992350206513
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/168	144/9376	0.775132275132275	TCF7L2/ADH1B	-0.367297606079136
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/168	144/9376	0.775132275132275	PLCB1/RBPJ	-0.367297606079136
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/168	73/9376	0.764514024787997	ADH1B	-0.272817729598194
NA	NA	hsa04519	Cadherin signaling	6/168	404/9376	0.828854314002829	TCF7L2/GJA1/PPP1CB/PDGFRA/MET/KRT18	-0.474973773944959
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/168	148/9376	0.754182754182754	TCF7L2/GADD45G	-0.407143060555163
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/168	216/9376	0.775132275132275	IL18/PLCB1/HSP90AB1	-0.451610351922097
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/168	76/9376	0.734335839598998	PLIN2	-0.314091305880166
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/168	76/9376	0.734335839598998	PLCB1	-0.314091305880166
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/168	149/9376	0.749121124960051	GNGT1/PLCB1	-0.416950588594636
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/168	77/9376	0.724799010513296	GADD45G	-0.327517758875464
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/168	77/9376	0.724799010513296	GADD45G	-0.327517758875464
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/168	78/9376	0.715506715506716	PLCB1	-0.340786336197557
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/168	78/9376	0.715506715506716	EEF1A1	-0.340786336197557
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/168	79/9376	0.706449668474985	ADH1B	-0.35390143947296
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/168	154/9376	0.724799010513296	DHFR/NAPRT	-0.465109720731015
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/168	154/9376	0.724799010513296	PLCB1/PPP1CB	-0.465109720731015
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/168	157/9376	0.710949347892023	TCF7L2/PPP1CB	-0.493332237478166
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/168	83/9376	0.672403901319564	SKP1	-0.40490899297734
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/168	83/9376	0.672403901319564	PRDX1	-0.40490899297734
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	2/168	160/9376	0.697619047619048	HLA-A/ALCAM	-0.521075690375191
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/168	298/9376	0.749121124960051	IL18/IL6ST/CCL20/PRLR	-0.59447659418094
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/168	86/9376	0.648947951273533	PLCB1	-0.441743842218219
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/168	87/9376	0.641488779419814	COX7A2L	-0.45376972957599
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/168	90/9376	0.62010582010582	SESN1	-0.48913324194375
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	4/168	308/9376	0.724799010513296	GPX3/PLCB1/CLTC/COX7A2L	-0.663326300786229
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/168	93/9376	0.600102406554019	PLCB1	-0.523484362990825
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/168	93/9376	0.600102406554019	PLCB1	-0.523484362990825
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/168	93/9376	0.600102406554019	GADD45G	-0.523484362990825
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/168	98/9376	0.569484936831876	PLCB1	-0.578671147439216
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/168	98/9376	0.569484936831876	CFL2	-0.578671147439216
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/168	181/9376	0.616679821099711	IL18/ATP6V0C	-0.703368195209272
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/168	102/9376	0.547152194211018	PLCB1	-0.62112131278679
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/168	103/9376	0.541840036985668	PPP1CB	-0.631514375758011
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/168	103/9376	0.541840036985668	PLCB1	-0.631514375758011
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/168	105/9376	0.531519274376417	GADD45G	-0.652049716562576
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/168	107/9376	0.521584334668447	PLCB1	-0.672261845433527
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/168	108/9376	0.516754850088183	EEF1A1	-0.682250704600915
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/168	110/9376	0.507359307359307	RPS6	-0.702001597722053
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/168	110/9376	0.507359307359307	HSP90AB1	-0.702001597722053
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/168	195/9376	0.572405372405372	PLCB1/HDAC9	-0.815008570479158
NA	NA	hsa04082	Neuroactive ligand signaling	2/168	199/9376	0.560899736779134	GNGT1/PLCB1	-0.845663319494633
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	2/168	200/9376	0.558095238095238	RPS3/IL18	-0.853246667262775
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/168	116/9376	0.48111658456486	ACSS1	-0.759540463042693
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/168	117/9376	0.477004477004477	INO80C	-0.768894020939262
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/168	125/9376	0.44647619047619	PLCB1	-0.841500922353006
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	4/168	368/9376	0.606625258799172	HNRNPA1/GPX3/ANG/COX7A2L	-1.03985746650432
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/168	128/9376	0.436011904761905	PDE1C	-0.867777998599227
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/168	217/9376	0.514373491332017	PTGES3/HSP90AB1	-0.977610475373275
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/168	133/9376	0.419620479770856	HLA-A	-0.910519071535957
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	2/168	224/9376	0.498299319727891	HLA-A/B2M	-1.02652213158078
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/168	226/9376	0.493889591234724	VIPR2/PPP1CB	-1.04027117677698
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	2/168	227/9376	0.491713866163205	MET/COX7A2L	-1.04710926124406
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/168	138/9376	0.404416839199448	IL18	-0.952029921789206
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/168	142/9376	0.393024815560027	ACP5	-0.984414034284936
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/168	143/9376	0.39027639027639	C7	-0.992401099599049
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/168	235/9376	0.474974670719352	RPS6/COX7A2L	-1.10096865951134
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/168	144/9376	0.387566137566138	IL6ST	-1.00034583302729
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/168	323/9376	0.518354710305175	PDGFRA/MET/FOXP1	-1.1898437731629
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/168	243/9376	0.45933764452283	HNRNPA1/PCBP1	-1.15340057577587
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/168	156/9376	0.357753357753358	EIF3E	-1.09258769430636
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/168	157/9376	0.355474673946012	BSG	-1.10003253372623
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/168	157/9376	0.355474673946012	COX7A2L	-1.10003253372623
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/168	173/9376	0.322598403523259	IL18	-1.21468083728119
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	2/168	275/9376	0.405887445887446	C7/COX7A2L	-1.35066654539681
NA	NA	hsa04382	Cornified envelope formation	1/168	217/9376	0.257186745666008	KRT18	-1.49535086269252
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/168	268/9376	0.208244491826581	COX7A2L	-1.7762520951367
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	3/168	480/9376	0.348809523809524	GPX3/PLCB1/COX7A2L	-1.97828517103249
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	2/168	388/9376	0.287677957781051	PLCB1/COX7A2L	-1.93561214360432
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/168	449/9376	0.124297380422102	PDE1C	-2.56853019604934