ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 41/265 175/18639 0.234285714285714 16.4786846361186 2.53171148870824e-38 1.56206598853298e-35 GO:0019843 rRNA binding 15/265 65/18639 0.230769230769231 16.2313497822932 1.44959317792646e-14 4.47199495390312e-12 GO:0045296 cadherin binding 20/265 334/18639 0.0598802395209581 4.21172748841939 7.13908301946626e-08 1.46827140767023e-05 GO:0048027 mRNA 5'-UTR binding 6/265 24/18639 0.25 17.5839622641509 8.4729728807263e-07 0.000130695606685203 GO:0008135 translation factor activity, RNA binding 9/265 83/18639 0.108433734939759 7.62677881336667 2.72087137478388e-06 0.000309521532997848 GO:0180051 translation factor activity 9/265 84/18639 0.107142857142857 7.53598382749326 3.00993387031943e-06 0.000309521532997848 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/265 59/18639 0.11864406779661 8.34493124400384 1.96921748458872e-05 0.0017357245542732 GO:0003743 translation initiation factor activity 6/265 51/18639 0.117647058823529 8.27480577136515 8.2205041449757e-05 0.00634006382181251 GO:0017046 peptide hormone binding 6/265 53/18639 0.113207547169811 7.9625489498042 0.00010233290951017 0.00701548946308611 GO:0004601 peroxidase activity 6/265 57/18639 0.105263157894737 7.40377358490566 0.000154261873226725 0.00951795757808891 GO:0051082 unfolded protein binding 8/265 121/18639 0.0661157024793388 4.6503040698581 0.000338599699298638 0.0189892232764609 GO:0042562 hormone binding 7/265 94/18639 0.074468085106383 5.23777599357688 0.000387511465244231 0.0189892232764609 GO:0008199 ferric iron binding 3/265 11/18639 0.272727272727273 19.1825042881647 0.000430873785851625 0.0189892232764609 GO:1990948 ubiquitin ligase inhibitor activity 3/265 11/18639 0.272727272727273 19.1825042881647 0.000430873785851625 0.0189892232764609 GO:0008198 ferrous iron binding 4/265 26/18639 0.153846153846154 10.8208998548621 0.000466695286473313 0.0191967327836023 GO:0043022 ribosome binding 7/265 112/18639 0.0625 4.39599056603774 0.00110526705176833 0.0413445548842628 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/265 15/18639 0.2 14.0671698113208 0.00113915305191648 0.0413445548842628 GO:0016209 antioxidant activity 6/265 86/18639 0.0697674418604651 4.90715225976305 0.00141906692302267 0.0486424606391661 GO:0003746 translation elongation factor activity 3/265 18/18639 0.166666666666667 11.722641509434 0.0019795781091036 0.061069984665846 GO:0050811 GABA receptor binding 3/265 18/18639 0.166666666666667 11.722641509434 0.0019795781091036 0.061069984665846 GO:0004857 enzyme inhibitor activity 14/265 416/18639 0.0336538461538462 2.36707184325109 0.00263340655127818 0.0721808656741297 GO:0043024 ribosomal small subunit binding 3/265 20/18639 0.15 10.5503773584906 0.00270818230262364 0.0721808656741297 GO:0005201 extracellular matrix structural constituent 8/265 168/18639 0.0476190476190476 3.34932614555256 0.0028300329424236 0.0721808656741297 GO:0033218 amide binding 10/265 247/18639 0.0404858299595142 2.84760522496372 0.00291223736078064 0.0721808656741297 GO:0048487 beta-tubulin binding 4/265 42/18639 0.0952380952380952 6.69865229110512 0.00292467040819002 0.0721808656741297 GO:0070851 growth factor receptor binding 7/265 139/18639 0.0503597122302158 3.54209311795846 0.00377127600151404 0.0894952804974679 GO:0004602 glutathione peroxidase activity 3/265 23/18639 0.130434782608696 9.17424118129614 0.00407710272511784 0.0905405211797739 GO:0031625 ubiquitin protein ligase binding 11/265 302/18639 0.0364238410596026 2.56190178682994 0.00410880809243706 0.0905405211797739 GO:0098631 cell adhesion mediator activity 5/265 76/18639 0.0657894736842105 4.62735849056604 0.00454738093638932 0.0967494495776624 GO:0044389 ubiquitin-like protein ligase binding 11/265 322/18639 0.0341614906832298 2.40277745224423 0.00657891134293138 0.135306276619622 GO:0004860 protein kinase inhibitor activity 5/265 84/18639 0.0595238095238095 4.1866576819407 0.00693580054253564 0.138044804346596 GO:0098632 cell-cell adhesion mediator activity 4/265 55/18639 0.0727272727272727 5.11533447684391 0.00772003097258933 0.148851847190238 GO:0030957 Tat protein binding 2/265 10/18639 0.2 14.0671698113208 0.00840490164859017 0.152524244622945 GO:0031720 haptoglobin binding 2/265 10/18639 0.2 14.0671698113208 0.00840490164859017 0.152524244622945 GO:0019210 kinase inhibitor activity 5/265 90/18639 0.0555555555555556 3.90754716981132 0.00922198196865057 0.162570367847354 GO:0019838 growth factor binding 6/265 136/18639 0.0441176470588235 3.10305216426193 0.0132249198288165 0.221457796111023 GO:0043021 ribonucleoprotein complex binding 7/265 177/18639 0.0395480225988701 2.78164374800128 0.013494714178225 0.221457796111023 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/265 13/18639 0.153846153846154 10.8208998548621 0.0141653809185652 0.221457796111023 GO:0035673 oligopeptide transmembrane transporter activity 2/265 13/18639 0.153846153846154 10.8208998548621 0.0141653809185652 0.221457796111023 GO:0055106 ubiquitin-protein transferase regulator activity 3/265 36/18639 0.0833333333333333 5.86132075471698 0.0143570694399367 0.221457796111023 GO:0005161 platelet-derived growth factor receptor binding 2/265 14/18639 0.142857142857143 10.0479784366577 0.0163727842614792 0.234930416030993 GO:0005344 oxygen carrier activity 2/265 14/18639 0.142857142857143 10.0479784366577 0.0163727842614792 0.234930416030993 GO:0098847 sequence-specific single stranded DNA binding 2/265 14/18639 0.142857142857143 10.0479784366577 0.0163727842614792 0.234930416030993 GO:0016722 oxidoreductase activity, acting on metal ions 2/265 16/18639 0.125 8.79198113207547 0.0211919981593201 0.290149779840657 GO:0043023 ribosomal large subunit binding 2/265 16/18639 0.125 8.79198113207547 0.0211919981593201 0.290149779840657 GO:0042056 chemoattractant activity 3/265 42/18639 0.0714285714285714 5.02398921832884 0.021695883547074 0.290149779840657 GO:0003725 double-stranded RNA binding 4/265 75/18639 0.0533333333333333 3.75124528301887 0.0221021712358361 0.290149779840657 GO:0008429 phosphatidylethanolamine binding 2/265 17/18639 0.117647058823529 8.27480577136515 0.0237953234000808 0.299626827303059 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/265 17/18639 0.117647058823529 8.27480577136515 0.0237953234000808 0.299626827303059 GO:0019199 transmembrane receptor protein kinase activity 4/265 78/18639 0.0512820512820513 3.60696661828737 0.0251055137279706 0.309802039403157 GO:0042277 peptide binding 8/265 249/18639 0.0321285140562249 2.25978631507161 0.0264217435339319 0.319651289420314 GO:0099106 ion channel regulator activity 6/265 160/18639 0.0375 2.63759433962264 0.0270280561114631 0.320501351875865 GO:0030291 protein serine/threonine kinase inhibitor activity 3/265 46/18639 0.0652173913043478 4.58712059064807 0.0275309102907955 0.320501351875865 GO:0003697 single-stranded DNA binding 5/265 121/18639 0.0413223140495868 2.90644004366131 0.0293860969814831 0.335763367362501 GO:0016505 peptidase activator activity involved in apoptotic process 2/265 20/18639 0.1 7.03358490566038 0.0323311894695397 0.362697161867382 GO:0016247 channel regulator activity 6/265 168/18639 0.0357142857142857 2.51199460916442 0.0331893136801661 0.364085066287558 GO:0005006 epidermal growth factor receptor activity 3/265 50/18639 0.06 4.22015094339623 0.0341171960161795 0.364085066287558 GO:0141108 transporter regulator activity 6/265 170/18639 0.0352941176470588 2.48244173140955 0.0348606409149403 0.364085066287558 GO:0070182 DNA polymerase binding 2/265 21/18639 0.0952380952380952 6.69865229110512 0.0354053549064076 0.364085066287558 GO:0072542 protein phosphatase activator activity 2/265 21/18639 0.0952380952380952 6.69865229110512 0.0354053549064076 0.364085066287558 GO:0008201 heparin binding 6/265 172/18639 0.0348837209302326 2.45357612988153 0.0365853840469446 0.370052163228931 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/265 22/18639 0.0909090909090909 6.39416809605489 0.0385876313014767 0.381226801120424 GO:0031072 heat shock protein binding 5/265 131/18639 0.0381679389312977 2.68457439147343 0.0393293565957698 0.381226801120424 GO:0016860 intramolecular oxidoreductase activity 3/265 53/18639 0.0566037735849057 3.9812744749021 0.0395437848812109 0.381226801120424 GO:0017134 fibroblast growth factor binding 2/265 23/18639 0.0869565217391304 6.11616078753076 0.0418743483087489 0.393332437122516 GO:0051087 protein-folding chaperone binding 5/265 134/18639 0.0373134328358209 2.62447197972402 0.0426664122018605 0.393332437122516 GO:0061134 peptidase regulator activity 7/265 226/18639 0.0309734513274336 2.17854399732844 0.0431687747655649 0.393332437122516 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/265 24/18639 0.0833333333333333 5.86132075471698 0.0452619173998357 0.393332437122516 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/265 24/18639 0.0833333333333333 5.86132075471698 0.0452619173998357 0.393332437122516 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/265 24/18639 0.0833333333333333 5.86132075471698 0.0452619173998357 0.393332437122516 GO:0050431 transforming growth factor beta binding 2/265 24/18639 0.0833333333333333 5.86132075471698 0.0452619173998357 0.393332437122516 GO:0016504 peptidase activator activity 3/265 57/18639 0.0526315789473684 3.70188679245283 0.0474155311899315 0.406324760335941 GO:0019211 phosphatase activator activity 2/265 25/18639 0.08 5.6268679245283 0.0487468302939042 0.412010880703273 GO:0015459 potassium channel regulator activity 3/265 59/18639 0.0508474576271186 3.57639910457307 0.0516183595514523 0.430385511395217 GO:0050750 low-density lipoprotein particle receptor binding 2/265 26/18639 0.0769230769230769 5.41044992743106 0.0523256574154621 0.430465741671202 GO:0019207 kinase regulator activity 8/265 287/18639 0.0278745644599303 1.96058115837223 0.0533333569116455 0.430980383250389 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/265 60/18639 0.05 3.51679245283019 0.0537852342143921 0.430980383250389 GO:0023026 MHC class II protein complex binding 2/265 27/18639 0.0740740740740741 5.21006289308176 0.0559950463795094 0.437329739454525 GO:0015026 coreceptor activity 3/265 61/18639 0.0491803278688525 3.45914011753789 0.0559952178556037 0.437329739454525 GO:0005539 glycosaminoglycan binding 7/265 242/18639 0.0289256198347107 2.03450803056292 0.058230600900235 0.449103509443062 GO:0045499 chemorepellent activity 2/265 28/18639 0.0714285714285714 5.02398921832884 0.0597517205035964 0.449595262813646 GO:0097718 disordered domain specific binding 2/265 28/18639 0.0714285714285714 5.02398921832884 0.0597517205035964 0.449595262813646 GO:1901682 sulfur compound transmembrane transporter activity 3/265 63/18639 0.0476190476190476 3.34932614555256 0.0605428276928532 0.450059333572174 GO:0001664 G protein-coupled receptor binding 8/265 297/18639 0.0269360269360269 1.894568324757 0.0625791412895365 0.459658692567191 GO:0001968 fibronectin binding 2/265 30/18639 0.0666666666666667 4.68905660377358 0.0675141872719061 0.490073571138424 GO:0005506 iron ion binding 5/265 154/18639 0.0324675324675325 2.28363146287675 0.0691686248240488 0.496244668795792 GO:0017147 Wnt-protein binding 2/265 31/18639 0.0645161290322581 4.53779671332928 0.0715137920401524 0.497955822490843 GO:0070325 lipoprotein particle receptor binding 2/265 31/18639 0.0645161290322581 4.53779671332928 0.0715137920401524 0.497955822490843 GO:0019887 protein kinase regulator activity 7/265 255/18639 0.0274509803921569 1.93078801331853 0.0725955375797374 0.497955822490843 GO:0032934 sterol binding 3/265 68/18639 0.0441176470588235 3.10305216426193 0.0726353711899123 0.497955822490843 GO:0003713 transcription coactivator activity 7/265 256/18639 0.02734375 1.92324587264151 0.0737803392256497 0.500246915409076 GO:0031369 translation initiation factor binding 2/265 32/18639 0.0625 4.39599056603774 0.0755883034217766 0.506934600122132 GO:0097110 scaffold protein binding 3/265 70/18639 0.0428571428571429 3.0143935309973 0.0777516917480414 0.515836492564963 GO:0005518 collagen binding 3/265 72/18639 0.0416666666666667 2.93066037735849 0.0830214977324862 0.520676419154406 GO:0019825 oxygen binding 2/265 34/18639 0.0588235294117647 4.13740288568258 0.083950435026101 0.520676419154406 GO:0005154 epidermal growth factor receptor binding 2/265 35/18639 0.0571428571428571 4.01919137466307 0.0882324167248344 0.520676419154406 GO:0003684 damaged DNA binding 3/265 74/18639 0.0405405405405405 2.85145334013259 0.0884405177231503 0.520676419154406 GO:0015399 primary active transmembrane transporter activity 5/265 166/18639 0.0301204819277108 2.11854967037963 0.0885964108221431 0.520676419154406 GO:0140297 DNA-binding transcription factor binding 11/265 488/18639 0.0225409836065574 1.5854392205382 0.0898685781552162 0.520676419154406 GO:0008528 G protein-coupled peptide receptor activity 4/265 122/18639 0.0327868852459016 2.30609341169193 0.0963832773121622 0.520676419154406 GO:0003712 transcription coregulator activity 11/265 495/18639 0.0222222222222222 1.56301886792453 0.0968066700971752 0.520676419154406 GO:0023023 MHC protein complex binding 2/265 37/18639 0.0540540540540541 3.80193778684345 0.0969846029209991 0.520676419154406 GO:0043394 proteoglycan binding 2/265 37/18639 0.0540540540540541 3.80193778684345 0.0969846029209991 0.520676419154406 GO:1901681 sulfur compound binding 7/265 275/18639 0.0254545454545455 1.79036706689537 0.0984484062860376 0.520676419154406 GO:0042887 amide transmembrane transporter activity 2/265 38/18639 0.0526315789473684 3.70188679245283 0.101449553431893 0.520676419154406 GO:0004519 endonuclease activity 4/265 127/18639 0.031496062992126 2.21530233249146 0.107562162103022 0.520676419154406 GO:0001618 virus receptor activity 3/265 81/18639 0.037037037037037 2.60503144654088 0.108517907355908 0.520676419154406 GO:0015101 organic cation transmembrane transporter activity 3/265 81/18639 0.037037037037037 2.60503144654088 0.108517907355908 0.520676419154406 GO:0001653 peptide receptor activity 4/265 128/18639 0.03125 2.19799528301887 0.109865557178999 0.520676419154406 GO:0031490 chromatin DNA binding 4/265 128/18639 0.03125 2.19799528301887 0.109865557178999 0.520676419154406 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/265 40/18639 0.05 3.51679245283019 0.110544493561813 0.520676419154406 GO:0140272 exogenous protein binding 3/265 82/18639 0.0365853658536585 2.57326277036355 0.111519527497704 0.520676419154406 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/265 130/18639 0.0307692307692308 2.16417997097242 0.11453819380067 0.520676419154406 GO:0004520 DNA endonuclease activity 2/265 42/18639 0.0476190476190476 3.34932614555256 0.119843276960031 0.520676419154406 GO:0035198 miRNA binding 2/265 42/18639 0.0476190476190476 3.34932614555256 0.119843276960031 0.520676419154406 GO:0051879 Hsp90 protein binding 2/265 42/18639 0.0476190476190476 3.34932614555256 0.119843276960031 0.520676419154406 GO:0008200 ion channel inhibitor activity 2/265 43/18639 0.0465116279069767 3.27143483984204 0.124563247033445 0.520676419154406 GO:0048156 tau protein binding 2/265 43/18639 0.0465116279069767 3.27143483984204 0.124563247033445 0.520676419154406 GO:0008081 phosphoric diester hydrolase activity 3/265 87/18639 0.0344827586206897 2.42537410540013 0.126989774597397 0.520676419154406 GO:0001046 core promoter sequence-specific DNA binding 2/265 44/18639 0.0454545454545455 3.19708404802744 0.129327254255049 0.520676419154406 GO:0016248 channel inhibitor activity 2/265 44/18639 0.0454545454545455 3.19708404802744 0.129327254255049 0.520676419154406 GO:0003727 single-stranded RNA binding 3/265 89/18639 0.0337078651685393 2.37087131651473 0.13338239433844 0.520676419154406 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0005381 iron ion transmembrane transporter activity 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0019531 oxalate transmembrane transporter activity 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0032356 oxidized DNA binding 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0043295 glutathione binding 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0051880 G-quadruplex DNA binding 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0070513 death domain binding 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0098505 G-rich strand telomeric DNA binding 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/265 10/18639 0.1 7.03358490566038 0.133445444624143 0.520676419154406 GO:0042605 peptide antigen binding 2/265 45/18639 0.0444444444444444 3.12603773584906 0.134133105211486 0.520676419154406 GO:0141110 transporter inhibitor activity 2/265 45/18639 0.0444444444444444 3.12603773584906 0.134133105211486 0.520676419154406 GO:0045182 translation regulator activity 8/265 356/18639 0.0224719101123595 1.58058087767649 0.136356201978651 0.520676419154406 GO:0004713 protein tyrosine kinase activity 4/265 140/18639 0.0285714285714286 2.00959568733154 0.139156736886066 0.520676419154406 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/265 91/18639 0.032967032967033 2.31876425461331 0.139884675943955 0.520676419154406 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0005114 type II transforming growth factor beta receptor binding 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0008271 secondary active sulfate transmembrane transporter activity 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0010854 adenylate cyclase regulator activity 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0015173 aromatic amino acid transmembrane transporter activity 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0031731 CCR6 chemokine receptor binding 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0042608 T cell receptor binding 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0048185 activin binding 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0048407 platelet-derived growth factor binding 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0050786 RAGE receptor binding 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:1900750 oligopeptide binding 1/265 11/18639 0.0909090909090909 6.39416809605489 0.145772298302526 0.520676419154406 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/265 48/18639 0.0416666666666667 2.93066037735849 0.14878057559431 0.520676419154406 GO:0019955 cytokine binding 4/265 144/18639 0.0277777777777778 1.95377358490566 0.149552801471511 0.520676419154406 GO:0004867 serine-type endopeptidase inhibitor activity 3/265 95/18639 0.0315789473684211 2.2211320754717 0.153198956194027 0.520676419154406 GO:0005004 GPI-linked ephrin receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0005008 hepatocyte growth factor receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0005009 insulin receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0005011 macrophage colony-stimulating factor receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0005020 stem cell factor receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0008288 boss receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0036332 placental growth factor receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0038062 protein tyrosine kinase collagen receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0060175 brain-derived neurotrophic factor receptor activity 2/265 49/18639 0.0408163265306122 2.87085098190219 0.153732912376644 0.520676419154406 GO:0003720 telomerase activity 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0008603 cAMP-dependent protein kinase regulator activity 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0015166 polyol transmembrane transporter activity 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0016208 AMP binding 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0043047 single-stranded telomeric DNA binding 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0045295 gamma-catenin binding 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0070008 serine-type exopeptidase activity 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0140900 chloride:bicarbonate antiporter activity 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:1990459 transferrin receptor binding 1/265 12/18639 0.0833333333333333 5.86132075471698 0.157924453174216 0.520676419154406 GO:0005007 fibroblast growth factor receptor activity 2/265 50/18639 0.04 2.81343396226415 0.15871690055833 0.520676419154406 GO:0005017 platelet-derived growth factor receptor activity 2/265 50/18639 0.04 2.81343396226415 0.15871690055833 0.520676419154406 GO:0005019 platelet-derived growth factor beta-receptor activity 2/265 50/18639 0.04 2.81343396226415 0.15871690055833 0.520676419154406 GO:0042626 ATPase-coupled transmembrane transporter activity 3/265 98/18639 0.0306122448979592 2.15313823642665 0.163436740185669 0.520676419154406 GO:0005010 insulin-like growth factor receptor activity 2/265 51/18639 0.0392156862745098 2.75826859045505 0.163730649495741 0.520676419154406 GO:0005021 vascular endothelial growth factor receptor activity 2/265 51/18639 0.0392156862745098 2.75826859045505 0.163730649495741 0.520676419154406 GO:0005030 neurotrophin receptor activity 2/265 51/18639 0.0392156862745098 2.75826859045505 0.163730649495741 0.520676419154406 GO:0030544 Hsp70 protein binding 2/265 51/18639 0.0392156862745098 2.75826859045505 0.163730649495741 0.520676419154406 GO:0005080 protein kinase C binding 2/265 52/18639 0.0384615384615385 2.70522496371553 0.168772315531011 0.520676419154406 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0003964 RNA-directed DNA polymerase activity 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0005172 vascular endothelial growth factor receptor binding 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0005542 folic acid binding 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0017154 semaphorin receptor activity 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0019104 DNA N-glycosylase activity 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0031994 insulin-like growth factor I binding 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0070123 transforming growth factor beta receptor activity, type III 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0070700 BMP receptor binding 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0140666 annealing activity 1/265 13/18639 0.0769230769230769 5.41044992743106 0.169904375862187 0.520676419154406 GO:0003730 mRNA 3'-UTR binding 6/265 262/18639 0.0229007633587786 1.61074463488406 0.170851552445676 0.520676419154406 GO:0005516 calmodulin binding 5/265 207/18639 0.0241545893719807 1.69893355209188 0.173010031290356 0.520676419154406 GO:0005003 ephrin receptor activity 2/265 53/18639 0.0377358490566038 2.65418298326807 0.17384010104669 0.520676419154406 GO:0005005 transmembrane-ephrin receptor activity 2/265 53/18639 0.0377358490566038 2.65418298326807 0.17384010104669 0.520676419154406 GO:0038064 collagen receptor activity 2/265 53/18639 0.0377358490566038 2.65418298326807 0.17384010104669 0.520676419154406 GO:0051018 protein kinase A binding 2/265 53/18639 0.0377358490566038 2.65418298326807 0.17384010104669 0.520676419154406 GO:0015485 cholesterol binding 2/265 54/18639 0.037037037037037 2.60503144654088 0.178932253537605 0.526374861252522 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/265 54/18639 0.037037037037037 2.60503144654088 0.178932253537605 0.526374861252522 GO:0008191 metalloendopeptidase inhibitor activity 1/265 14/18639 0.0714285714285714 5.02398921832884 0.18171449829301 0.526374861252522 GO:0008494 translation activator activity 1/265 14/18639 0.0714285714285714 5.02398921832884 0.18171449829301 0.526374861252522 GO:0034236 protein kinase A catalytic subunit binding 1/265 14/18639 0.0714285714285714 5.02398921832884 0.18171449829301 0.526374861252522 GO:1901474 azole transmembrane transporter activity 1/265 14/18639 0.0714285714285714 5.02398921832884 0.18171449829301 0.526374861252522 GO:1990825 sequence-specific mRNA binding 1/265 14/18639 0.0714285714285714 5.02398921832884 0.18171449829301 0.526374861252522 GO:0008013 beta-catenin binding 3/265 106/18639 0.0283018867924528 1.99063723745105 0.19166291049291 0.534983872730734 GO:0004089 carbonate dehydratase activity 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0004129 cytochrome-c oxidase activity 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0005523 tropomyosin binding 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0015116 sulfate transmembrane transporter activity 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0015929 hexosaminidase activity 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0017081 chloride channel regulator activity 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0141050 histone H3K deacetylase activity 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0141051 histone H4K deacetylase activity 1/265 15/18639 0.0666666666666667 4.68905660377358 0.193357218183069 0.534983872730734 GO:0019888 protein phosphatase regulator activity 3/265 107/18639 0.0280373831775701 1.97203315111973 0.195275273661982 0.537878767185012 GO:0004866 endopeptidase inhibitor activity 4/265 161/18639 0.0248447204968944 1.74747451072308 0.196742330143668 0.538437478737374 GO:0005496 steroid binding 3/265 108/18639 0.0277777777777778 1.95377358490566 0.198904400441702 0.538437478737374 GO:0061980 regulatory RNA binding 2/265 58/18639 0.0344827586206897 2.42537410540013 0.199511011515946 0.538437478737374 GO:0008083 growth factor activity 4/265 162/18639 0.0246913580246914 1.73668763102725 0.19965144097702 0.538437478737374 GO:0005024 transforming growth factor beta receptor activity 1/265 16/18639 0.0625 4.39599056603774 0.204834899517986 0.538437478737374 GO:0005521 lamin binding 1/265 16/18639 0.0625 4.39599056603774 0.204834899517986 0.538437478737374 GO:0015562 efflux transmembrane transporter activity 1/265 16/18639 0.0625 4.39599056603774 0.204834899517986 0.538437478737374 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/265 16/18639 0.0625 4.39599056603774 0.204834899517986 0.538437478737374 GO:0022858 alanine transmembrane transporter activity 1/265 16/18639 0.0625 4.39599056603774 0.204834899517986 0.538437478737374 GO:0034450 ubiquitin-ubiquitin ligase activity 1/265 16/18639 0.0625 4.39599056603774 0.204834899517986 0.538437478737374 GO:0001217 DNA-binding transcription repressor activity 6/265 278/18639 0.0215827338129496 1.51803990769648 0.205077483797865 0.538437478737374 GO:0098531 ligand-modulated transcription factor activity 2/265 60/18639 0.0333333333333333 2.34452830188679 0.209904192655727 0.547839208622742 GO:0004549 tRNA-specific ribonuclease activity 1/265 17/18639 0.0588235294117647 4.13740288568258 0.216149873025355 0.547839208622742 GO:0005092 GDP-dissociation inhibitor activity 1/265 17/18639 0.0588235294117647 4.13740288568258 0.216149873025355 0.547839208622742 GO:0030169 low-density lipoprotein particle binding 1/265 17/18639 0.0588235294117647 4.13740288568258 0.216149873025355 0.547839208622742 GO:0051787 misfolded protein binding 1/265 17/18639 0.0588235294117647 4.13740288568258 0.216149873025355 0.547839208622742 GO:0070402 NADPH binding 1/265 17/18639 0.0588235294117647 4.13740288568258 0.216149873025355 0.547839208622742 GO:1990226 histone methyltransferase binding 1/265 17/18639 0.0588235294117647 4.13740288568258 0.216149873025355 0.547839208622742 GO:0015179 L-amino acid transmembrane transporter activity 2/265 62/18639 0.032258064516129 2.26889835666464 0.220350564474881 0.547839208622742 GO:0030414 peptidase inhibitor activity 4/265 169/18639 0.0236686390532544 1.66475382382494 0.220363902838107 0.547839208622742 GO:0035401 histone H3Y41 kinase activity 3/265 115/18639 0.0260869565217391 1.83484823625923 0.224730441300408 0.547839208622742 GO:0140801 histone H2AXY142 kinase activity 3/265 115/18639 0.0260869565217391 1.83484823625923 0.224730441300408 0.547839208622742 GO:0000400 four-way junction DNA binding 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0000900 mRNA regulatory element binding translation repressor activity 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0017128 phospholipid scramblase activity 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0031690 adrenergic receptor binding 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0098641 cadherin binding involved in cell-cell adhesion 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:1990381 ubiquitin-specific protease binding 1/265 18/18639 0.0555555555555556 3.90754716981132 0.227304436640879 0.547839208622742 GO:0004536 DNA nuclease activity 2/265 64/18639 0.03125 2.19799528301887 0.230838890974115 0.553223796699812 GO:0019208 phosphatase regulator activity 3/265 117/18639 0.0256410256410256 1.80348330914369 0.232228465713535 0.553223796699812 GO:1990782 protein tyrosine kinase binding 3/265 117/18639 0.0256410256410256 1.80348330914369 0.232228465713535 0.553223796699812 GO:0022853 active monoatomic ion transmembrane transporter activity 3/265 118/18639 0.0254237288135593 1.78819955228654 0.235994640015168 0.556937985349435 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/265 19/18639 0.0526315789473684 3.70188679245283 0.238300855967991 0.556937985349435 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/265 19/18639 0.0526315789473684 3.70188679245283 0.238300855967991 0.556937985349435 GO:0005520 insulin-like growth factor binding 1/265 19/18639 0.0526315789473684 3.70188679245283 0.238300855967991 0.556937985349435 GO:0008301 DNA binding, bending 1/265 19/18639 0.0526315789473684 3.70188679245283 0.238300855967991 0.556937985349435 GO:0016500 protein-hormone receptor activity 2/265 67/18639 0.0298507462686567 2.09957758377922 0.246626907019812 0.571450639550441 GO:0050840 extracellular matrix binding 2/265 67/18639 0.0298507462686567 2.09957758377922 0.246626907019812 0.571450639550441 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/265 20/18639 0.05 3.51679245283019 0.249141364731068 0.571450639550441 GO:0010851 cyclase regulator activity 1/265 20/18639 0.05 3.51679245283019 0.249141364731068 0.571450639550441 GO:0016004 phospholipase activator activity 1/265 20/18639 0.05 3.51679245283019 0.249141364731068 0.571450639550441 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 2/265 68/18639 0.0294117647058824 2.06870144284129 0.251899377802536 0.575636726311721 GO:0036122 BMP binding 1/265 21/18639 0.0476190476190476 3.34932614555256 0.259828165222301 0.589389624787351 GO:0051010 microtubule plus-end binding 1/265 21/18639 0.0476190476190476 3.34932614555256 0.259828165222301 0.589389624787351 GO:0008237 metallopeptidase activity 4/265 184/18639 0.0217391304347826 1.52904019688269 0.266445819932888 0.597900485785031 GO:0061135 endopeptidase regulator activity 4/265 184/18639 0.0217391304347826 1.52904019688269 0.266445819932888 0.597900485785031 GO:0015078 proton transmembrane transporter activity 4/265 185/18639 0.0216216216216216 1.52077511473738 0.2695832074464 0.597900485785031 GO:0042826 histone deacetylase binding 3/265 127/18639 0.0236220472440945 1.66147674936859 0.27031196991405 0.597900485785031 GO:0004407 histone deacetylase activity 1/265 22/18639 0.0454545454545455 3.19708404802744 0.27036342874234 0.597900485785031 GO:0005243 gap junction channel activity 1/265 22/18639 0.0454545454545455 3.19708404802744 0.27036342874234 0.597900485785031 GO:0033558 protein lysine deacetylase activity 1/265 22/18639 0.0454545454545455 3.19708404802744 0.27036342874234 0.597900485785031 GO:0046982 protein heterodimerization activity 7/265 369/18639 0.018970189701897 1.33428439944777 0.272620842936347 0.598465068499603 GO:0004521 RNA endonuclease activity 2/265 73/18639 0.0273972602739726 1.92700956319462 0.278282990624752 0.598465068499603 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/265 23/18639 0.0434782608695652 3.05808039376538 0.280749296034776 0.598465068499603 GO:0005158 insulin receptor binding 1/265 23/18639 0.0434782608695652 3.05808039376538 0.280749296034776 0.598465068499603 GO:0005212 structural constituent of eye lens 1/265 23/18639 0.0434782608695652 3.05808039376538 0.280749296034776 0.598465068499603 GO:0008171 O-methyltransferase activity 1/265 23/18639 0.0434782608695652 3.05808039376538 0.280749296034776 0.598465068499603 GO:0031681 G-protein beta-subunit binding 1/265 23/18639 0.0434782608695652 3.05808039376538 0.280749296034776 0.598465068499603 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/265 23/18639 0.0434782608695652 3.05808039376538 0.280749296034776 0.598465068499603 GO:0140104 molecular carrier activity 5/265 249/18639 0.0200803212851406 1.41236644691975 0.280913643468953 0.598465068499603 GO:0048029 monosaccharide binding 2/265 74/18639 0.027027027027027 1.90096889342172 0.283556392649796 0.598465068499603 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0015149 hexose transmembrane transporter activity 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0015295 solute:proton symporter activity 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0030215 semaphorin receptor binding 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0030552 cAMP binding 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0055056 D-glucose transmembrane transporter activity 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0060229 lipase activator activity 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0070840 dynein complex binding 1/265 24/18639 0.0416666666666667 2.93066037735849 0.290987877714556 0.598465068499603 GO:0017022 myosin binding 2/265 76/18639 0.0263157894736842 1.85094339622642 0.294091762239542 0.600843103648337 GO:0051536 iron-sulfur cluster binding 2/265 76/18639 0.0263157894736842 1.85094339622642 0.294091762239542 0.600843103648337 GO:0051540 metal cluster binding 2/265 77/18639 0.025974025974026 1.8269051703014 0.299351830711957 0.601188136388307 GO:0005251 delayed rectifier potassium channel activity 1/265 25/18639 0.04 2.81343396226415 0.301081254690416 0.601188136388307 GO:0005537 D-mannose binding 1/265 25/18639 0.04 2.81343396226415 0.301081254690416 0.601188136388307 GO:0015645 fatty acid ligase activity 1/265 25/18639 0.04 2.81343396226415 0.301081254690416 0.601188136388307 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/265 25/18639 0.04 2.81343396226415 0.301081254690416 0.601188136388307 GO:0120020 cholesterol transfer activity 1/265 25/18639 0.04 2.81343396226415 0.301081254690416 0.601188136388307 GO:0120515 fatty acid-CoA ligase activity 1/265 25/18639 0.04 2.81343396226415 0.301081254690416 0.601188136388307 GO:0015631 tubulin binding 7/265 385/18639 0.0181818181818182 1.27883361921098 0.308347153844425 0.603479315360795 GO:0016835 carbon-oxygen lyase activity 2/265 79/18639 0.0253164556962025 1.7806544064963 0.309852192949764 0.603479315360795 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/265 26/18639 0.0384615384615385 2.70522496371553 0.311031478581415 0.603479315360795 GO:0004435 phosphatidylinositol phospholipase C activity 1/265 26/18639 0.0384615384615385 2.70522496371553 0.311031478581415 0.603479315360795 GO:0005112 Notch binding 1/265 26/18639 0.0384615384615385 2.70522496371553 0.311031478581415 0.603479315360795 GO:0005160 transforming growth factor beta receptor binding 1/265 26/18639 0.0384615384615385 2.70522496371553 0.311031478581415 0.603479315360795 GO:0015145 monosaccharide transmembrane transporter activity 1/265 26/18639 0.0384615384615385 2.70522496371553 0.311031478581415 0.603479315360795 GO:0050681 nuclear androgen receptor binding 1/265 26/18639 0.0384615384615385 2.70522496371553 0.311031478581415 0.603479315360795 GO:0097602 cullin family protein binding 1/265 26/18639 0.0384615384615385 2.70522496371553 0.311031478581415 0.603479315360795 GO:0000049 tRNA binding 2/265 80/18639 0.025 1.75839622641509 0.315090749712578 0.605378082577232 GO:0140767 enzyme-substrate adaptor activity 3/265 139/18639 0.0215827338129496 1.51803990769648 0.316799790684339 0.605378082577232 GO:0004364 glutathione transferase activity 1/265 27/18639 0.037037037037037 2.60503144654088 0.320840572127642 0.605378082577232 GO:0005044 scavenger receptor activity 1/265 27/18639 0.037037037037037 2.60503144654088 0.320840572127642 0.605378082577232 GO:0005104 fibroblast growth factor receptor binding 1/265 27/18639 0.037037037037037 2.60503144654088 0.320840572127642 0.605378082577232 GO:0008320 protein transmembrane transporter activity 1/265 27/18639 0.037037037037037 2.60503144654088 0.320840572127642 0.605378082577232 GO:0015252 proton channel activity 1/265 27/18639 0.037037037037037 2.60503144654088 0.320840572127642 0.605378082577232 GO:0016405 CoA-ligase activity 1/265 27/18639 0.037037037037037 2.60503144654088 0.320840572127642 0.605378082577232 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/265 27/18639 0.037037037037037 2.60503144654088 0.320840572127642 0.605378082577232 GO:0022804 active transmembrane transporter activity 8/265 457/18639 0.0175054704595186 1.23126212790554 0.325373573347345 0.61099632767151 GO:0020037 heme binding 3/265 142/18639 0.0211267605633803 1.48596864204092 0.328470823149874 0.61099632767151 GO:0003714 transcription corepressor activity 4/265 204/18639 0.0196078431372549 1.37913429522752 0.330151548967922 0.61099632767151 GO:0051119 sugar transmembrane transporter activity 1/265 28/18639 0.0357142857142857 2.51199460916442 0.330510529595199 0.61099632767151 GO:0051537 2 iron, 2 sulfur cluster binding 1/265 28/18639 0.0357142857142857 2.51199460916442 0.330510529595199 0.61099632767151 GO:0001540 amyloid-beta binding 2/265 83/18639 0.0240963855421687 1.69483973630371 0.330750037993978 0.61099632767151 GO:0030165 PDZ domain binding 2/265 83/18639 0.0240963855421687 1.69483973630371 0.330750037993978 0.61099632767151 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 5/265 268/18639 0.0186567164179104 1.31223598986201 0.333594711112627 0.613469961103196 GO:0019903 protein phosphatase binding 3/265 144/18639 0.0208333333333333 1.46533018867925 0.336250605375906 0.613469961103196 GO:0004181 metallocarboxypeptidase activity 1/265 29/18639 0.0344827586206897 2.42537410540013 0.340043317175516 0.613469961103196 GO:0004629 phospholipase C activity 1/265 29/18639 0.0344827586206897 2.42537410540013 0.340043317175516 0.613469961103196 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/265 29/18639 0.0344827586206897 2.42537410540013 0.340043317175516 0.613469961103196 GO:0043236 laminin binding 1/265 29/18639 0.0344827586206897 2.42537410540013 0.340043317175516 0.613469961103196 GO:0051861 glycolipid binding 1/265 29/18639 0.0344827586206897 2.42537410540013 0.340043317175516 0.613469961103196 GO:0097472 cyclin-dependent protein kinase activity 1/265 29/18639 0.0344827586206897 2.42537410540013 0.340043317175516 0.613469961103196 GO:0004518 nuclease activity 4/265 209/18639 0.0191387559808612 1.34614065180103 0.346267036691128 0.621340112031405 GO:0001965 G-protein alpha-subunit binding 1/265 30/18639 0.0333333333333333 2.34452830188679 0.349440873379088 0.621340112031405 GO:0033612 receptor serine/threonine kinase binding 1/265 30/18639 0.0333333333333333 2.34452830188679 0.349440873379088 0.621340112031405 GO:0048019 receptor antagonist activity 1/265 30/18639 0.0333333333333333 2.34452830188679 0.349440873379088 0.621340112031405 GO:0051721 protein phosphatase 2A binding 1/265 30/18639 0.0333333333333333 2.34452830188679 0.349440873379088 0.621340112031405 GO:0005126 cytokine receptor binding 5/265 275/18639 0.0181818181818182 1.27883361921098 0.35326295922222 0.62350546767553 GO:0004175 endopeptidase activity 7/265 405/18639 0.0172839506172839 1.21568134171908 0.354162513784801 0.62350546767553 GO:0005184 neuropeptide hormone activity 1/265 31/18639 0.032258064516129 2.26889835666464 0.358705109423719 0.62350546767553 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/265 31/18639 0.032258064516129 2.26889835666464 0.358705109423719 0.62350546767553 GO:0005452 solute:inorganic anion antiporter activity 1/265 31/18639 0.032258064516129 2.26889835666464 0.358705109423719 0.62350546767553 GO:0016878 acid-thiol ligase activity 1/265 31/18639 0.032258064516129 2.26889835666464 0.358705109423719 0.62350546767553 GO:0072349 modified amino acid transmembrane transporter activity 1/265 31/18639 0.032258064516129 2.26889835666464 0.358705109423719 0.62350546767553 GO:0046906 tetrapyrrole binding 3/265 152/18639 0.0197368421052632 1.38820754716981 0.367296325120973 0.62350546767553 GO:0015106 bicarbonate transmembrane transporter activity 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0022884 macromolecule transmembrane transporter activity 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0043425 bHLH transcription factor binding 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0051059 NF-kappaB binding 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0071813 lipoprotein particle binding 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0071814 protein-lipid complex binding 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0120015 sterol transfer activity 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0160041 neuropeptide activity 1/265 32/18639 0.03125 2.19799528301887 0.36783790961733 0.62350546767553 GO:0072341 modified amino acid binding 2/265 91/18639 0.021978021978022 1.54584283640887 0.371964474689207 0.628772824337645 GO:0030296 protein tyrosine kinase activator activity 1/265 33/18639 0.0303030303030303 2.13138936535163 0.376841131735426 0.630730807948371 GO:0140416 transcription regulator inhibitor activity 1/265 33/18639 0.0303030303030303 2.13138936535163 0.376841131735426 0.630730807948371 GO:0043178 alcohol binding 2/265 92/18639 0.0217391304347826 1.52904019688269 0.377048675585448 0.630730807948371 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 6/265 349/18639 0.0171919770773639 1.20921230469806 0.377211779794082 0.630730807948371 GO:0008175 tRNA methyltransferase activity 1/265 34/18639 0.0294117647058824 2.06870144284129 0.385716607393284 0.638035246009803 GO:0008376 acetylgalactosaminyltransferase activity 1/265 34/18639 0.0294117647058824 2.06870144284129 0.385716607393284 0.638035246009803 GO:0030332 cyclin binding 1/265 34/18639 0.0294117647058824 2.06870144284129 0.385716607393284 0.638035246009803 GO:0090482 vitamin transmembrane transporter activity 1/265 34/18639 0.0294117647058824 2.06870144284129 0.385716607393284 0.638035246009803 GO:0016229 steroid dehydrogenase activity 1/265 35/18639 0.0285714285714286 2.00959568733154 0.394466142412945 0.647302153906348 GO:0034061 DNA polymerase activity 1/265 35/18639 0.0285714285714286 2.00959568733154 0.394466142412945 0.647302153906348 GO:0061631 ubiquitin conjugating enzyme activity 1/265 35/18639 0.0285714285714286 2.00959568733154 0.394466142412945 0.647302153906348 GO:0004896 cytokine receptor activity 2/265 96/18639 0.0208333333333333 1.46533018867925 0.397209967762466 0.650075729733266 GO:0005484 SNAP receptor activity 1/265 36/18639 0.0277777777777778 1.95377358490566 0.403091517185067 0.656220227185189 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/265 36/18639 0.0277777777777778 1.95377358490566 0.403091517185067 0.656220227185189 GO:0005249 voltage-gated potassium channel activity 2/265 98/18639 0.0204081632653061 1.4354254909511 0.407178148133563 0.661128729995812 GO:0019213 deacetylase activity 1/265 37/18639 0.027027027027027 1.90096889342172 0.411594487025736 0.663064748028405 GO:0022829 wide pore channel activity 1/265 37/18639 0.027027027027027 1.90096889342172 0.411594487025736 0.663064748028405 GO:0030551 cyclic nucleotide binding 1/265 37/18639 0.027027027027027 1.90096889342172 0.411594487025736 0.663064748028405 GO:0043130 ubiquitin binding 2/265 100/18639 0.02 1.40671698113208 0.417066323731319 0.666132840154098 GO:0005109 frizzled binding 1/265 38/18639 0.0263157894736842 1.85094339622642 0.419976782528272 0.666132840154098 GO:0005501 retinoid binding 1/265 38/18639 0.0263157894736842 1.85094339622642 0.419976782528272 0.666132840154098 GO:0019840 isoprenoid binding 1/265 38/18639 0.0263157894736842 1.85094339622642 0.419976782528272 0.666132840154098 GO:0042162 telomeric DNA binding 1/265 38/18639 0.0263157894736842 1.85094339622642 0.419976782528272 0.666132840154098 GO:0043531 ADP binding 1/265 38/18639 0.0263157894736842 1.85094339622642 0.419976782528272 0.666132840154098 GO:0016874 ligase activity 3/265 167/18639 0.0179640718562874 1.26351824652582 0.424697979680149 0.67061966450394 GO:0008238 exopeptidase activity 2/265 102/18639 0.0196078431372549 1.37913429522752 0.426871062010786 0.67061966450394 GO:0015171 amino acid transmembrane transporter activity 2/265 102/18639 0.0196078431372549 1.37913429522752 0.426871062010786 0.67061966450394 GO:0000217 DNA secondary structure binding 1/265 39/18639 0.0256410256410256 1.80348330914369 0.428240109910134 0.67061966450394 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/265 39/18639 0.0256410256410256 1.80348330914369 0.428240109910134 0.67061966450394 GO:0015144 carbohydrate transmembrane transporter activity 1/265 40/18639 0.025 1.75839622641509 0.436386151354963 0.678212230191466 GO:0071855 neuropeptide receptor binding 1/265 40/18639 0.025 1.75839622641509 0.436386151354963 0.678212230191466 GO:0140662 ATP-dependent protein folding chaperone 1/265 40/18639 0.025 1.75839622641509 0.436386151354963 0.678212230191466 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/265 41/18639 0.024390243902439 1.7155085135757 0.444416565349851 0.680409480945058 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/265 41/18639 0.024390243902439 1.7155085135757 0.444416565349851 0.680409480945058 GO:0017080 sodium channel regulator activity 1/265 41/18639 0.024390243902439 1.7155085135757 0.444416565349851 0.680409480945058 GO:0042169 SH2 domain binding 1/265 41/18639 0.024390243902439 1.7155085135757 0.444416565349851 0.680409480945058 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/265 41/18639 0.024390243902439 1.7155085135757 0.444416565349851 0.680409480945058 GO:0140318 protein transporter activity 1/265 41/18639 0.024390243902439 1.7155085135757 0.444416565349851 0.680409480945058 GO:0031492 nucleosomal DNA binding 1/265 42/18639 0.0238095238095238 1.67466307277628 0.452332987017896 0.690815477698123 GO:0004252 serine-type endopeptidase activity 3/265 176/18639 0.0170454545454545 1.19890651801029 0.458290955613349 0.698186468181325 GO:0004222 metalloendopeptidase activity 2/265 110/18639 0.0181818181818182 1.27883361921098 0.465195708170185 0.704027517435013 GO:0042393 histone binding 4/265 247/18639 0.0161943319838057 1.13904208998549 0.467403202867982 0.704027517435013 GO:0001223 transcription coactivator binding 1/265 44/18639 0.0227272727272727 1.59854202401372 0.467830279008679 0.704027517435013 GO:0030547 signaling receptor inhibitor activity 1/265 44/18639 0.0227272727272727 1.59854202401372 0.467830279008679 0.704027517435013 GO:0043014 alpha-tubulin binding 1/265 44/18639 0.0227272727272727 1.59854202401372 0.467830279008679 0.704027517435013 GO:0016853 isomerase activity 3/265 180/18639 0.0166666666666667 1.1722641509434 0.472956469507665 0.708528083594669 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/265 45/18639 0.0222222222222222 1.56301886792453 0.475414305685888 0.708528083594669 GO:0046915 transition metal ion transmembrane transporter activity 1/265 45/18639 0.0222222222222222 1.56301886792453 0.475414305685888 0.708528083594669 GO:0140303 intramembrane lipid transporter activity 1/265 45/18639 0.0222222222222222 1.56301886792453 0.475414305685888 0.708528083594669 GO:0004180 carboxypeptidase activity 1/265 46/18639 0.0217391304347826 1.52904019688269 0.482890653378329 0.716210416188531 GO:0030276 clathrin binding 1/265 46/18639 0.0217391304347826 1.52904019688269 0.482890653378329 0.716210416188531 GO:0001221 transcription coregulator binding 2/265 115/18639 0.0173913043478261 1.22323215750615 0.488370959817355 0.722601635988748 GO:0005504 fatty acid binding 1/265 47/18639 0.0212765957446809 1.49650742673625 0.49026084521691 0.723662539470894 GO:0015294 solute:monoatomic cation symporter activity 2/265 116/18639 0.0172413793103448 1.21268705270007 0.492930563393406 0.725866724615111 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/265 48/18639 0.0208333333333333 1.46533018867925 0.497526382868455 0.728376000239673 GO:0038187 pattern recognition receptor activity 1/265 48/18639 0.0208333333333333 1.46533018867925 0.497526382868455 0.728376000239673 GO:0031406 carboxylic acid binding 3/265 187/18639 0.0160427807486631 1.12838260518616 0.498176129823569 0.728376000239673 GO:0046943 carboxylic acid transmembrane transporter activity 3/265 188/18639 0.0159574468085106 1.12238057005219 0.501729786543409 0.730098341020114 GO:0140597 protein carrier chaperone 3/265 188/18639 0.0159574468085106 1.12238057005219 0.501729786543409 0.730098341020114 GO:0060590 ATPase regulator activity 1/265 49/18639 0.0204081632653061 1.4354254909511 0.504688746837034 0.730098341020114 GO:0005342 organic acid transmembrane transporter activity 3/265 189/18639 0.0158730158730159 1.11644204851752 0.505270650916675 0.730098341020114 GO:0043177 organic acid binding 3/265 189/18639 0.0158730158730159 1.11644204851752 0.505270650916675 0.730098341020114 GO:0019902 phosphatase binding 3/265 190/18639 0.0157894736842105 1.11056603773585 0.508798565526405 0.733478305910729 GO:0032182 ubiquitin-like protein binding 2/265 120/18639 0.0166666666666667 1.1722641509434 0.510910547996174 0.734300878608354 GO:0048020 CCR chemokine receptor binding 1/265 50/18639 0.02 1.40671698113208 0.51174939676109 0.734300878608354 GO:0004540 RNA nuclease activity 2/265 121/18639 0.0165289256198347 1.16257601746453 0.515340044325483 0.737198719485414 GO:0005048 signal sequence binding 1/265 51/18639 0.0196078431372549 1.37913429522752 0.518709771706396 0.737198719485414 GO:0016597 amino acid binding 1/265 51/18639 0.0196078431372549 1.37913429522752 0.518709771706396 0.737198719485414 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/265 122/18639 0.0163934426229508 1.15304670584596 0.5197430194103 0.737198719485414 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/265 122/18639 0.0163934426229508 1.15304670584596 0.5197430194103 0.737198719485414 GO:0140097 catalytic activity, acting on DNA 5/265 336/18639 0.0148809523809524 1.04666442048517 0.521856148938472 0.738109508791247 GO:0008236 serine-type peptidase activity 3/265 194/18639 0.0154639175257732 1.08766776891655 0.522777723406443 0.738109508791247 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/265 52/18639 0.0192307692307692 1.35261248185776 0.525571290454933 0.740359557558662 GO:0005267 potassium channel activity 2/265 124/18639 0.0161290322580645 1.13444917833232 0.528468841079792 0.742745501016473 GO:0008514 organic anion transmembrane transporter activity 4/265 269/18639 0.0148698884758364 1.04588623132496 0.533926268912084 0.748404858228427 GO:0017171 serine hydrolase activity 3/265 198/18639 0.0151515151515152 1.06569468267581 0.536538159764106 0.748404858228427 GO:0017069 snRNA binding 1/265 54/18639 0.0185185185185185 1.30251572327044 0.539003334775596 0.748404858228427 GO:0050661 NADP binding 1/265 54/18639 0.0185185185185185 1.30251572327044 0.539003334775596 0.748404858228427 GO:0140463 chromatin-protein adaptor activity 1/265 54/18639 0.0185185185185185 1.30251572327044 0.539003334775596 0.748404858228427 GO:0005096 GTPase activator activity 4/265 271/18639 0.014760147601476 1.03816751375061 0.539773358041572 0.748404858228427 GO:0016829 lyase activity 3/265 200/18639 0.015 1.05503773584906 0.543333773929308 0.751652328507586 GO:0140313 molecular sequestering activity 1/265 55/18639 0.0181818181818182 1.27883361921098 0.545576599036261 0.753066580772647 GO:0008017 microtubule binding 4/265 276/18639 0.0144927536231884 1.01936013125513 0.554227340731237 0.763299708105298 GO:0005179 hormone activity 2/265 132/18639 0.0151515151515152 1.06569468267581 0.562286989522492 0.770957938967505 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2/265 132/18639 0.0151515151515152 1.06569468267581 0.562286989522492 0.770957938967505 GO:0030246 carbohydrate binding 4/265 280/18639 0.0142857142857143 1.00479784366577 0.565616341450695 0.772534058239711 GO:0141003 histone H2AX kinase activity 5/265 354/18639 0.0141242937853107 0.993444195714743 0.568283553948633 0.772534058239711 GO:0004879 nuclear receptor activity 1/265 59/18639 0.0169491525423729 1.19213303485769 0.570948996041018 0.772534058239711 GO:0036002 pre-mRNA binding 1/265 59/18639 0.0169491525423729 1.19213303485769 0.570948996041018 0.772534058239711 GO:0070063 RNA polymerase binding 1/265 59/18639 0.0169491525423729 1.19213303485769 0.570948996041018 0.772534058239711 GO:0070888 E-box binding 1/265 59/18639 0.0169491525423729 1.19213303485769 0.570948996041018 0.772534058239711 GO:0140996 histone H3 kinase activity 5/265 357/18639 0.0140056022408964 0.985095925162518 0.57579754139569 0.777389678427004 GO:0016922 nuclear receptor binding 2/265 137/18639 0.0145985401459854 1.0268007161548 0.582528438849026 0.778919709757792 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/265 61/18639 0.0163934426229508 1.15304670584596 0.583100848712383 0.778919709757792 GO:0016836 hydro-lyase activity 1/265 61/18639 0.0163934426229508 1.15304670584596 0.583100848712383 0.778919709757792 GO:0019905 syntaxin binding 1/265 61/18639 0.0163934426229508 1.15304670584596 0.583100848712383 0.778919709757792 GO:0035173 histone kinase activity 5/265 360/18639 0.0138888888888889 0.97688679245283 0.583242959332415 0.778919709757792 GO:0140101 catalytic activity, acting on a tRNA 2/265 139/18639 0.0143884892086331 1.01202660513099 0.590430538812456 0.785369581612664 GO:0042578 phosphoric ester hydrolase activity 5/265 363/18639 0.0137741046831956 0.968813347887104 0.590618291520707 0.785369581612664 GO:0005507 copper ion binding 1/265 63/18639 0.0158730158730159 1.11644204851752 0.594909791010608 0.789374926996872 GO:0022843 voltage-gated monoatomic cation channel activity 2/265 143/18639 0.013986013986014 0.983718168623829 0.605900562488457 0.797739512110393 GO:0038024 cargo receptor activity 1/265 65/18639 0.0153846153846154 1.08208998548621 0.606385463824594 0.797739512110393 GO:0120013 lipid transfer activity 1/265 65/18639 0.0153846153846154 1.08208998548621 0.606385463824594 0.797739512110393 GO:0160215 deacylase activity 1/265 65/18639 0.0153846153846154 1.08208998548621 0.606385463824594 0.797739512110393 GO:0008235 metalloexopeptidase activity 1/265 66/18639 0.0151515151515152 1.06569468267581 0.612001262903224 0.803414423853807 GO:0015293 symporter activity 2/265 146/18639 0.0136986301369863 0.963504781597312 0.61721076753334 0.805540118057696 GO:0008173 RNA methyltransferase activity 1/265 67/18639 0.0149253731343284 1.04978879188961 0.617537237992367 0.805540118057696 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/265 67/18639 0.0149253731343284 1.04978879188961 0.617537237992367 0.805540118057696 GO:0003777 microtubule motor activity 1/265 68/18639 0.0147058823529412 1.03435072142064 0.622994519487737 0.807537013705744 GO:0005548 phospholipid transporter activity 1/265 68/18639 0.0147058823529412 1.03435072142064 0.622994519487737 0.807537013705744 GO:1990841 promoter-specific chromatin binding 1/265 68/18639 0.0147058823529412 1.03435072142064 0.622994519487737 0.807537013705744 GO:0019209 kinase activator activity 2/265 148/18639 0.0135135135135135 0.950484446710862 0.6246119737694 0.807936242800251 GO:0002039 p53 binding 1/265 69/18639 0.0144927536231884 1.01936013125513 0.628374221837409 0.811102290530714 GO:0000510 H3-H4 histone complex chaperone activity 2/265 151/18639 0.0132450331125828 0.931600649756341 0.635506040478114 0.813500470902481 GO:0140584 chromatin extrusion motor activity 2/265 151/18639 0.0132450331125828 0.931600649756341 0.635506040478114 0.813500470902481 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/265 151/18639 0.0132450331125828 0.931600649756341 0.635506040478114 0.813500470902481 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/265 151/18639 0.0132450331125828 0.931600649756341 0.635506040478114 0.813500470902481 GO:0015616 DNA translocase activity 2/265 152/18639 0.0131578947368421 0.925471698113208 0.639082170016209 0.814697725000002 GO:0140674 ATP-dependent histone chaperone activity 2/265 152/18639 0.0131578947368421 0.925471698113208 0.639082170016209 0.814697725000002 GO:0061775 cohesin loader activity 2/265 153/18639 0.0130718954248366 0.919422863485017 0.642630770831724 0.817532341449843 GO:0042379 chemokine receptor binding 1/265 72/18639 0.0138888888888889 0.97688679245283 0.644058763963391 0.81766308099879 GO:0140375 immune receptor activity 2/265 156/18639 0.0128205128205128 0.901741654571843 0.653111988077755 0.827066960286969 GO:0031491 nucleosome binding 1/265 74/18639 0.0135135135135135 0.950484446710862 0.654146963727781 0.827066960286969 GO:0044183 protein folding chaperone 1/265 75/18639 0.0133333333333333 0.937811320754717 0.659083729395012 0.831014591761272 GO:0140658 ATP-dependent chromatin remodeler activity 2/265 158/18639 0.0126582278481013 0.890327203248149 0.659962965904414 0.831014591761272 GO:0003689 DNA clamp loader activity 2/265 160/18639 0.0125 0.879198113207547 0.666705421187198 0.834728516652083 GO:0015079 potassium ion transmembrane transporter activity 2/265 160/18639 0.0125 0.879198113207547 0.666705421187198 0.834728516652083 GO:0003724 RNA helicase activity 1/265 77/18639 0.012987012987013 0.913452585150698 0.668747637091889 0.834728516652083 GO:0008186 ATP-dependent activity, acting on RNA 1/265 79/18639 0.0126582278481013 0.890327203248149 0.678138607789984 0.834728516652083 GO:0015370 solute:sodium symporter activity 1/265 79/18639 0.0126582278481013 0.890327203248149 0.678138607789984 0.834728516652083 GO:0033293 monocarboxylic acid binding 1/265 79/18639 0.0126582278481013 0.890327203248149 0.678138607789984 0.834728516652083 GO:0046332 SMAD binding 1/265 79/18639 0.0126582278481013 0.890327203248149 0.678138607789984 0.834728516652083 GO:0140713 histone chaperone activity 2/265 164/18639 0.0121951219512195 0.857754256787851 0.679867381255557 0.834728516652083 GO:0048306 calcium-dependent protein binding 1/265 80/18639 0.0125 0.879198113207547 0.682734150297293 0.834728516652083 GO:0030971 receptor tyrosine kinase binding 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:0033192 calmodulin-dependent protein phosphatase activity 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:0140791 histone H2AXS140 phosphatase activity 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:1990439 MAP kinase serine/threonine phosphatase activity 1/265 81/18639 0.0123456790123457 0.868343815513627 0.687264321651958 0.834728516652083 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 1/265 82/18639 0.0121951219512195 0.857754256787851 0.691730048279947 0.836857725075936 GO:0033549 MAP kinase phosphatase activity 1/265 82/18639 0.0121951219512195 0.857754256787851 0.691730048279947 0.836857725075936 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 1/265 83/18639 0.0120481927710843 0.847419868151853 0.696132243527337 0.840535409503654 GO:0017018 myosin phosphatase activity 1/265 84/18639 0.0119047619047619 0.83733153638814 0.700471807844284 0.84412325281235 GO:0005244 voltage-gated monoatomic ion channel activity 2/265 173/18639 0.0115606936416185 0.813131202966518 0.707934955121119 0.851035760995769 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/265 86/18639 0.0116279069767442 0.817858709960509 0.70896658209372 0.851035760995769 GO:0003823 antigen binding 2/265 174/18639 0.0114942528735632 0.808458035133377 0.710923803355723 0.851728129457245 GO:0022832 voltage-gated channel activity 2/265 175/18639 0.0114285714285714 0.803838274932615 0.713887111444774 0.85362082899501 GO:0004197 cysteine-type endopeptidase activity 1/265 88/18639 0.0113636363636364 0.799271012006861 0.717221323540975 0.854646142123599 GO:0005261 monoatomic cation channel activity 4/265 341/18639 0.0117302052785924 0.82505394787805 0.717514913484642 0.854646142123599 GO:0005319 lipid transporter activity 2/265 178/18639 0.0112359550561798 0.790290438838245 0.722624992754353 0.859074413351514 GO:0051213 dioxygenase activity 1/265 93/18639 0.010752688172043 0.756299452221546 0.736851914779882 0.872625012320897 GO:0051219 phosphoprotein binding 1/265 93/18639 0.010752688172043 0.756299452221546 0.736851914779882 0.872625012320897 GO:0004674 protein serine/threonine kinase activity 5/265 433/18639 0.0115473441108545 0.812192252385725 0.740469471025533 0.875229240656616 GO:0008276 protein methyltransferase activity 1/265 95/18639 0.0105263157894737 0.740377358490566 0.744318526091337 0.878096616822859 GO:0030594 neurotransmitter receptor activity 1/265 97/18639 0.0103092783505155 0.725111845944369 0.751574055251035 0.884964107041772 GO:0003779 actin binding 5/265 443/18639 0.0112866817155756 0.793858341496657 0.758203887118965 0.891070092099812 GO:0046873 metal ion transmembrane transporter activity 5/265 450/18639 0.0111111111111111 0.781509433962264 0.770070535562647 0.903295666239835 GO:0004722 protein serine/threonine phosphatase activity 1/265 103/18639 0.00970873786407767 0.682872320937901 0.772132773855325 0.903996055917905 GO:0015291 secondary active transmembrane transporter activity 3/265 287/18639 0.0104529616724739 0.735217934389587 0.777797387696737 0.908903386759255 GO:0000149 SNARE binding 1/265 106/18639 0.00943396226415094 0.663545745817017 0.781767344857398 0.911815598822334 GO:0008168 methyltransferase activity 2/265 204/18639 0.00980392156862745 0.689567147613762 0.789292367147728 0.918855453830468 GO:0004620 phospholipase activity 1/265 109/18639 0.00917431192660551 0.645283018867924 0.790996023882601 0.919104607788258 GO:1902936 phosphatidylinositol bisphosphate binding 1/265 111/18639 0.00900900900900901 0.633656297807241 0.796931424336599 0.92277999670316 GO:0051015 actin filament binding 2/265 209/18639 0.00956937799043062 0.673070325900515 0.800372562783581 0.92277999670316 GO:0008094 ATP-dependent activity, acting on DNA 2/265 210/18639 0.00952380952380952 0.669865229110512 0.802525852177759 0.92277999670316 GO:0140098 catalytic activity, acting on RNA 4/265 387/18639 0.0103359173126615 0.726985519964897 0.803526551877097 0.92277999670316 GO:0017124 SH3 domain binding 1/265 115/18639 0.00869565217391304 0.611616078753076 0.808303144070276 0.92277999670316 GO:0101005 deubiquitinase activity 1/265 115/18639 0.00869565217391304 0.611616078753076 0.808303144070276 0.92277999670316 GO:0009055 electron transfer activity 1/265 116/18639 0.00862068965517241 0.606343526350033 0.811045514337031 0.92277999670316 GO:0016741 transferase activity, transferring one-carbon groups 2/265 215/18639 0.00930232558139535 0.654286967968407 0.81298663258467 0.92277999670316 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 5/265 484/18639 0.0103305785123967 0.726610010915328 0.821486539112861 0.92277999670316 GO:0015108 chloride transmembrane transporter activity 1/265 121/18639 0.00826446280991736 0.581288008732263 0.824182061827885 0.92277999670316 GO:0030695 GTPase regulator activity 5/265 489/18639 0.0102249488752556 0.71918046070147 0.828209362252209 0.92277999670316 GO:0060589 nucleoside-triphosphatase regulator activity 5/265 490/18639 0.0102040816326531 0.717712745475549 0.82952913295071 0.92277999670316 GO:0001216 DNA-binding transcription activator activity 5/265 491/18639 0.010183299389002 0.716251008723053 0.830840703499721 0.92277999670316 GO:0005543 phospholipid binding 5/265 497/18639 0.0100603621730382 0.707604115257583 0.838539508608465 0.92277999670316 GO:0019783 ubiquitin-like protein peptidase activity 1/265 127/18639 0.0078740157480315 0.553825583122864 0.838750224508777 0.92277999670316 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 1/265 128/18639 0.0078125 0.549498820754717 0.841058521316533 0.92277999670316 GO:0005085 guanyl-nucleotide exchange factor activity 2/265 230/18639 0.00869565217391304 0.611616078753076 0.841466087438989 0.92277999670316 GO:0035591 signaling adaptor activity 1/265 129/18639 0.00775193798449612 0.545239139973673 0.843333897679297 0.92277999670316 GO:0016298 lipase activity 1/265 130/18639 0.00769230769230769 0.541044992743106 0.845576821348394 0.92277999670316 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/265 130/18639 0.00769230769230769 0.541044992743106 0.845576821348394 0.92277999670316 GO:0016887 ATP hydrolysis activity 4/265 417/18639 0.00959232613908873 0.67468440342066 0.847289370618678 0.92277999670316 GO:0005262 calcium channel activity 1/265 131/18639 0.00763358778625954 0.536914878294685 0.847787753454001 0.92277999670316 GO:0015297 antiporter activity 1/265 135/18639 0.00740740740740741 0.521006289308176 0.856320562297058 0.92277999670316 GO:0002020 protease binding 1/265 136/18639 0.00735294117647059 0.517175360710322 0.858378228260703 0.92277999670316 GO:0016779 nucleotidyltransferase activity 1/265 136/18639 0.00735294117647059 0.517175360710322 0.858378228260703 0.92277999670316 GO:0044325 transmembrane transporter binding 1/265 136/18639 0.00735294117647059 0.517175360710322 0.858378228260703 0.92277999670316 GO:0140789 histone phosphatase activity 1/265 136/18639 0.00735294117647059 0.517175360710322 0.858378228260703 0.92277999670316 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 2/265 243/18639 0.00823045267489712 0.578895877009085 0.862914824276443 0.92277999670316 GO:0030295 protein kinase activator activity 1/265 139/18639 0.00719424460431655 0.506013302565495 0.864376737407782 0.92277999670316 GO:0004676 3-phosphoinositide-dependent protein kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0004711 ribosomal protein S6 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0035175 histone H3S10 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0035979 histone H2AXS139 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0044022 histone H3S28 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0044023 histone H4S1 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0044024 histone H2AS1 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0044025 histone H2BS14 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0072354 histone H3T3 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0072371 histone H2AS121 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0072518 Rho-dependent protein serine/threonine kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0140823 histone H2BS36 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0140855 histone H3S57 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0140995 histone H2A kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0140997 histone H4 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0140998 histone H2B kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:1990244 histone H2AT120 kinase activity 2/265 245/18639 0.00816326530612245 0.574170196380439 0.865969236098601 0.92277999670316 GO:0004677 DNA-dependent protein kinase activity 2/265 246/18639 0.00813008130081301 0.571836171191901 0.867472995699982 0.92277999670316 GO:0140857 histone H3T45 kinase activity 2/265 246/18639 0.00813008130081301 0.571836171191901 0.867472995699982 0.92277999670316 GO:0035402 histone H3T11 kinase activity 2/265 247/18639 0.00809716599190283 0.569521044992743 0.868961303196504 0.92277999670316 GO:0035403 histone H3T6 kinase activity 2/265 247/18639 0.00809716599190283 0.569521044992743 0.868961303196504 0.92277999670316 GO:0004679 AMP-activated protein kinase activity 2/265 248/18639 0.00806451612903226 0.567224589166159 0.870434291865866 0.92277999670316 GO:0008194 UDP-glycosyltransferase activity 1/265 145/18639 0.00689655172413793 0.485074821080026 0.875624939559051 0.926690544953575 GO:0015085 calcium ion transmembrane transporter activity 1/265 147/18639 0.00680272108843537 0.478475163650366 0.879163831339212 0.926693830107467 GO:0061630 ubiquitin protein ligase activity 3/265 353/18639 0.0084985835694051 0.59775509113261 0.881089136619431 0.926693830107467 GO:0008509 monoatomic anion transmembrane transporter activity 1/265 149/18639 0.00671140939597315 0.47205267823224 0.882602398844658 0.926693830107467 GO:0005216 monoatomic ion channel activity 4/265 448/18639 0.00892857142857143 0.627998652291105 0.883604134581438 0.926693830107467 GO:0019842 vitamin binding 1/265 150/18639 0.00666666666666667 0.468905660377359 0.884284949645424 0.926693830107467 GO:0004842 ubiquitin-protein transferase activity 4/265 449/18639 0.0089086859688196 0.626599991595579 0.884639653052347 0.926693830107467 GO:0003774 cytoskeletal motor activity 1/265 153/18639 0.0065359477124183 0.459711431742508 0.889189815816626 0.92932276865628 GO:0106310 protein serine kinase activity 3/265 361/18639 0.00831024930747922 0.584508440913605 0.890161679539484 0.92932276865628 GO:0004386 helicase activity 1/265 155/18639 0.00645161290322581 0.453779671332928 0.892344095562874 0.930027545544415 GO:0005178 integrin binding 1/265 161/18639 0.0062111801242236 0.436868627680769 0.901280219153365 0.936031745210645 GO:0061659 ubiquitin-like protein ligase activity 3/265 372/18639 0.00806451612903226 0.567224589166159 0.901627548468351 0.936031745210645 GO:0016791 phosphatase activity 2/265 273/18639 0.00732600732600733 0.515280945469625 0.902656221070233 0.936031745210645 GO:0015081 sodium ion transmembrane transporter activity 1/265 164/18639 0.00609756097560976 0.428877128393925 0.905467154416905 0.937202439455006 GO:0015103 inorganic anion transmembrane transporter activity 1/265 165/18639 0.00606060606060606 0.426277873070326 0.906823105923239 0.937202439455006 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/265 167/18639 0.00598802395209581 0.421172748841939 0.909477153725393 0.93837358503105 GO:0019787 ubiquitin-like protein transferase activity 4/265 479/18639 0.00835073068893528 0.587355733249301 0.912191957086457 0.938668110213542 GO:0031267 small GTPase binding 2/265 283/18639 0.00706713780918728 0.497073138209214 0.913322305560041 0.938668110213542 GO:0035091 phosphatidylinositol binding 2/265 284/18639 0.00704225352112676 0.495322880680308 0.914326635718539 0.938668110213542 GO:0004721 phosphoprotein phosphatase activity 1/265 175/18639 0.00571428571428571 0.401919137466307 0.919361137100966 0.94226880663006 GO:0016755 aminoacyltransferase activity 4/265 496/18639 0.00806451612903226 0.567224589166159 0.925069594689355 0.94599345734144 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/265 181/18639 0.00552486187845304 0.388595851141457 0.926061666506045 0.94599345734144 GO:1901981 phosphatidylinositol phosphate binding 1/265 185/18639 0.00540540540540541 0.380193778684345 0.930217534009357 0.948668129725245 GO:0008234 cysteine-type peptidase activity 1/265 187/18639 0.0053475935828877 0.376127535062052 0.932207354317137 0.949128609923554 GO:0051020 GTPase binding 2/265 315/18639 0.00634920634920635 0.446576819407008 0.940552223715116 0.955023823263032 GO:0016758 hexosyltransferase activity 1/265 197/18639 0.0050761421319797 0.357034766784791 0.941339825066105 0.955023823263032 GO:0022836 gated channel activity 2/265 318/18639 0.00628930817610063 0.442363830544678 0.942641018423317 0.955023823263032 GO:0030371 translation repressor activity 2/265 329/18639 0.0060790273556231 0.427573550496072 0.949719860349165 0.960252247849729 GO:0003924 GTPase activity 2/265 331/18639 0.00604229607250755 0.424990024511201 0.95091430054487 0.960252247849729 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 1/265 229/18639 0.00436681222707424 0.307143445662025 0.963099951574079 0.97096841523073 GO:0005125 cytokine activity 1/265 234/18639 0.00427350427350427 0.300580551523948 0.965680621817098 0.971981963558156 GO:0005525 GTP binding 2/265 378/18639 0.00529100529100529 0.37214734950584 0.972312864508084 0.977063578829785 GO:0016757 glycosyltransferase activity 1/265 267/18639 0.00374531835205993 0.263430146279415 0.978742832376039 0.97891868952349 GO:0019001 guanyl nucleotide binding 2/265 400/18639 0.005 0.351679245283019 0.97891868952349 0.97891868952349 GO:0032561 guanyl ribonucleotide binding 2/265 400/18639 0.005 0.351679245283019 0.97891868952349 0.97891868952349