category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/382	155/9376	3.95879074480662	MARCO/CD36/CALR/HLA-A/ATP6V0E1/ATP6V0C/TUBA1B/TUBB6/ATP6V0B/TUBB4B/ATP6V1G1/CANX/TUBA1A/MRC1/HLA-DRB5/ITGB5/ACTG1/STX7/COLEC12/HLA-DPA1/HLA-DPB1/LAMP1/ATP6V1B2/ATP6V1A/HLA-G	7.65476685400386
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	25/382	174/9376	3.52650899681049	DNAJA1/HSP90AA1/HSP90AB1/CALR/HSPA1B/HSPA1A/HSPH1/DDIT3/SKP1/HSPA8/CANX/HSP90B1/STT3B/ATF4/MAN1A1/HSPA6/ERN1/DNAJB1/TRAM1/DNAJB11/OSTC/CRYAB/DNAJC3/SSR3/PDIA6	6.93258553732001
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/382	82/9376	4.78917124249777	HSP90AA1/HSP90AB1/CALR/HLA-A/HSPA1B/B2M/HSPA1A/HSPA8/CANX/HSPA6/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-G/NFYC/HSPA2	7.1021641007295
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	27/382	250/9376	2.65080628272251	CD63/CLTC/ATP6V0E1/ATP6V0C/ATP6V0B/HEXB/ATP6V1G1/CTSA/CLTA/ARL8A/LAPTM4A/FUCA1/ASAH1/MCOLN1/NEU1/GLA/LAMTOR3/LAMP1/ATP6V1B2/NPC2/ATP6V1A/CD68/VPS26A/LAMTOR1/PPT1/LIPA/AP1G1	5.45213703864086
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	26/382	250/9376	2.55262827225131	RAB31/LDLR/HLA-A/HSPA1B/CLTC/HSPA1A/RHOA/WWP1/CDC42/HSPA8/CLTA/SNX2/ARF4/CAPZA2/HSPA6/ARPC5/ARPC3/SNX3/EPS15/GBF1/CHMP5/SPART/HLA-G/VPS26A/VPS28/IQSEC3	5.12788338582137
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/382	42/9376	5.25953627524308	FTL/FTH1/HMOX1/PCBP1/PCBP2/PRNP/GPX4/SAT2/SLC3A2	5.70156324485605
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	22/382	216/9376	2.49990304440566	LDLR/HSP90AA1/HSPD1/CD36/HSP90AB1/HSPA1B/HSPA1A/DDIT3/CALM2/CALM3/RHOA/CDC42/HSPA8/HSP90B1/ATF4/HSPA6/ERN1/TNFRSF1A/HSPA2/GSK3B/PPP3R1/CYCS	4.59603368896415
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	24/382	248/9376	2.37527444688397	AHNAK/DYNLL1/HSP90AA1/HSP90AB1/TUBA1B/TUBB6/TUBB4B/MYL12A/RHOA/CDC42/SKP1/RHOB/ARL8A/HSP90B1/TUBA1A/ARPC5/ARPC3/GAPDH/ACTG1/MYL12B/TNFRSF1A/ANXA2/DYNLRB1/CYCS	4.52343419178872
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	24/382	275/9376	2.14206568300809	HSPA1B/HSPA1A/TUBA1B/TUBB6/TUBB4B/DDIT3/PRNP/HSPA8/TUBA1A/ATF4/PSMA2/HSPA6/GRIN2D/SOD1/PSMB3/MT-CO1/SLC25A5/PSMB1/STIP1/GSK3B/NDUFC2/PPP3R1/CYCS/ATF2	3.96144608644145
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	15/382	139/9376	2.64868733285623	HSP90AA1/HSP90AB1/SHC2/HSPA1B/HSPA1A/FKBP4/CALM2/CALM3/FKBP5/HSPA8/HSP90B1/ATF4/HSPA6/NCOA3/ATF2	4.03572074784425
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/382	142/9376	2.59272914976772	UBB/UBC/UBE2S/UBE2A/PIAS1/WWP1/SKP1/UBE2B/CUL4B/HUWE1/UBR5/UBE2W/UBA6/HERC1/UBE2Q2	3.94123239314976
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/382	142/9376	2.59272914976772	HSP90AA1/HSP90AB1/KLF2/HMOX1/GSTP1/CALM2/CALM3/RHOA/MEF2C/HSP90B1/SUMO2/PDGFB/ACTG1/SUMO1/TNFRSF1A	3.94123239314976
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/382	51/9376	3.85011805769428	ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/ACTG1/ATP6V1B2/SLC12A2/ATP6V1A	4.20595280918832
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	17/382	181/9376	2.30528477625756	HSPD1/ATP6V0C/ATP6V0B/CALM2/CALM3/RHOA/MRC1/HSPA9/HLA-DRB5/HLA-DPA1/HLA-DPB1/LAMP1/CEBPB/TNFRSF1A/NFYC/PPP3R1/CYCS	3.65434521530567
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/382	78/9376	3.14673110484629	SHC2/FN1/CLTC/RHOA/CDC42/CLTA/ARPC5/ARPC3/ACTG1/SEPTIN2	3.92347651586127
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	33/382	480/9376	1.68743455497382	DKK2/UBB/PRKCB/TUBA1B/TUBB6/TUBB4B/UBC/DDIT3/CALM2/CALM3/PRNP/ATP2A2/CAT/TUBA1A/ATF4/DKK1/PSMA2/ERN1/FUS/PARK7/GRIN2D/SOD1/PSMB3/MT-CO1/GPX3/SLC25A5/PSMB1/TNFRSF1A/SMCR8/GSK3B/NDUFC2/PPP3R1/CYCS	3.18636459973835
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	27/382	368/9376	1.80081948554519	SRSF3/HNRNPA2B1/TUBA1B/TUBB6/TUBB4B/DDIT3/HNRNPA1/CAT/TUBA1A/ATF4/PSMA2/ERN1/FUS/ACTG1/GRIN2D/SRSF7/SOD1/PSMB3/MT-CO1/GPX3/PSMB1/TNFRSF1A/SETX/SMCR8/NDUFC2/PPP3R1/CYCS	3.22987139700671
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	23/382	300/9376	1.88174520069808	JUND/HSPA1B/HSPA1A/PRKCB/STMN1/DDIT3/CDC42/HSPA8/MEF2C/HSPB1/ATF4/TAOK1/INSR/HSPA6/LAMTOR3/NR4A1/PDGFB/GADD45B/STK4/TNFRSF1A/PPP3R1/RASA1/ATF2	3.19887571057718
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	16/382	180/9376	2.18173356602676	SRSF3/CALR/BST2/HLA-A/B2M/OAS1/SRSF2/SRSF6/HLA-DRB5/SRSF7/HLA-DPA1/HLA-DPB1/TNFRSF1A/HLA-G/CYCS/TNFRSF14	3.29911322506443
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/382	103/9376	2.62125756112438	SAP18/PCF11/PAPOLA/PPP2R3A/PPP2R5C/ETF1/SMG5/FUS/SMG1/CPSF7/RBM8A	3.40958384811369
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/382	268/9376	1.92326326482769	UBB/TUBA1B/TUBB6/TUBB4B/UBC/DDIT3/CALM2/CALM3/TUBA1A/ATF4/PSMA2/ERN1/PARK7/SOD1/PSMB3/MT-CO1/SLC39A12/SLC25A5/PSMB1/NDUFC2/CYCS	3.16025640428713
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/382	62/9376	3.1670325958453	HSPA1B/HSPA1A/HSPA8/CAT/INSR/HSPA6/SOD1/CRYAB	3.52804446376068
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	19/382	238/9376	1.9594350829337	CFD/PRKCB/RPL14/RPL10/RPS9/RPL9/RPS4X/RPL8/RPL18A/OAS1/RPL7A/RPS7/IL6ST/RPS3A/RPL18/RPL3/TNFRSF1A/RPL11/RPS5	3.08972178248728
Genetic Information Processing	Translation	hsa03010	Ribosome	18/382	222/9376	1.99009480684873	MRPS6/MRPL18/RPL14/RPL10/RPS9/RPL9/RPS4X/RPL8/RPL18A/RPL7A/RPS7/MRPL14/RPS3A/RPL18/RPL3/RPL11/RACK1/RPS5	3.07672509495209
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	27/382	388/9376	1.7079937388676	DKK2/TUBA1B/TUBB6/TUBB4B/DDIT3/RTN3/CALM2/CALM3/ATP2A2/TUBA1A/ATF4/DKK1/INSR/PSMA2/ERN1/GAPDH/GRIN2D/PSMB3/MT-CO1/SLC39A12/SLC25A5/PSMB1/TNFRSF1A/GSK3B/NDUFC2/PPP3R1/CYCS	2.93531440582485
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/382	28/9376	4.3829468960359	ATP6V0E1/ATP6V0C/ATP6V1G1/ATP6V1B2/ATP6V1A	3.69450043759445
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/382	112/9376	2.41062079281975	LDLR/HSPA1B/HSPA1A/HSPA8/HSPA6/HLA-DRB5/HLA-DPA1/HLA-DPB1/TNFRSF1A/LAMB2/CYCS	3.09500173862703
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/382	83/9376	2.66145209108686	PRDX1/CAT/ABCD4/DHRS4/SOD1/PEX6/PRDX5/ECH1/SCP2	3.13321197927159
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/382	69/9376	2.84573943394795	PRKCB/CALM2/CALM3/ATF4/FOSB/GRIN2D/PPP3R1/ATF2	3.17125348438749
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/382	56/9376	3.06806282722513	HSPD1/HSPA1B/HSPA1A/EEF1A1/HSPA8/HSPA6/CYCS	3.19882634211104
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/382	70/9376	2.80508601346298	HLA-A/EIF4G2/HLA-DRB5/ACTG1/HLA-DPA1/HLA-DPB1/HLA-G/CYCS	3.1239658312487
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/382	20/9376	4.90890052356021	CYP51A1/DHCR24/SQLE/LIPA	3.6063293605221
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/382	44/9376	3.34697762970014	HSPD1/HLA-A/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-G	3.2157983004395
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/382	158/9376	2.01948439260388	PRKCB/ATP6V1G1/RHOA/FNIP1/INSR/LAMTOR3/EIF4B/ATP6V1B2/TNFRSF1A/SLC3A2/ATP6V1A/LAMTOR1/GSK3B	2.6633709048756
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	15/382	196/9376	1.87840581258681	UBB/HLA-A/UBC/CALM2/CALM3/ZFP36/CLEC2B/IL6ST/PDGFB/TNFRSF1A/HLA-G/GSK3B/PPP3R1/CYCS/GNG11	2.56119575916247
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/382	79/9376	2.48551925243555	CLTC/ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/CLTA/ATP6V1B2/ATP6V1A	2.73250706098089
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/382	95/9376	2.32526866905484	ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/HLA-DRB5/HLA-DPA1/HLA-DPB1/ATP6V1B2/ATP6V1A	2.67552630503508
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/382	50/9376	2.94534031413613	P4HA1/AOC1/AMD1/ODC1/OAT/SAT2	2.84232517433652
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/382	200/9376	1.84083769633508	TUBA1B/TUBB6/TMBIM6/TUBB4B/RHOA/CDC42/TUBA1A/EZR/ARPC5/ARPC3/GAPDH/ACTG1/MYO1D/TNFRSF1A/CYCS	2.47708749633266
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	15/382	203/9376	1.81363319835968	SHC2/FN1/PRKCB/EMP2/MYL12A/RHOA/CDC42/PDGFB/ITGB5/EMP1/ACTG1/MYL12B/LAMB2/GSK3B/SPP1	2.41524872137783
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/382	39/9376	3.14673110484629	HLA-A/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-G	2.7685167228492
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/382	137/9376	1.97072648756067	TUBA1B/DDIT3/PMAIP1/LMNA/TUBA1A/ATF4/ERN1/ACTG1/GADD45B/TNFRSF1A/CYCS	2.35876979676747
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/382	71/9376	2.4198805397832	ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/CDC42/ATP6V1B2/ATP6V1A	2.47493427769352
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/382	214/9376	1.7204090619954	CALR/BST2/HLA-A/B2M/PRKCB/CALM2/CALM3/SKP1/CUL4B/TNFRSF1A/HLA-G/AP1G1/PPP3R1/CYCS/GNG11	2.1970087579169
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/382	30/9376	3.27260034904014	DHFR/ABCC5/SLC46A1/SHMT1	2.56928147818942
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/382	59/9376	2.49605111367468	HPGDS/GSTP1/GPX4/ODC1/GPX3/PRDX6	2.37561067356817
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/382	44/9376	2.78914802475012	HEXB/MAN2A1/STT3B/MAN1A1/OSTC	2.4514674125638
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/382	144/9376	1.87492728330425	PRKCB/GTF2B/ATP2A2/PSMA2/ERN1/GRIN2D/PSMB3/PUM2/SLC25A5/PSMB1/CYCS	2.180450268372
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/382	18/9376	4.09075043630017	HEXB/FUCA1/NEU1	2.7048896330091
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/382	45/9376	2.72716695753345	HLA-A/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-G	2.39341143221979
NA	NA	hsa04981	Folate transport and metabolism	4/382	31/9376	3.1670325958453	DHFR/ABCC5/SLC46A1/SHMT1	2.49056290879986
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/382	166/9376	1.77430139405791	KCNMA1/CALM2/CALM3/RHOA/MEF2C/ATP2A2/ATF4/INSR/SLC25A5/PPP3R1/CNGA1/ATF2	2.07431710279928
Human Diseases	Immune disease	hsa05310	Asthma	4/382	32/9376	3.06806282722513	PRG2/HLA-DRB5/HLA-DPA1/HLA-DPB1	2.4149780107356
Genetic Information Processing	Transcription	hsa03040	Spliceosome	16/382	243/9376	1.6160989377976	SRSF3/HSPA1B/HSPA1A/PCBP1/HNRNPA1/HSPA8/HNRNPK/TRA2A/SRSF2/HSPA6/SRSF6/FUS/HNRNPM/SRSF7/BUD31/RBM8A	2.00533875047695
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	15/382	224/9376	1.64360508601346	CALR/HLA-A/B2M/CANX/ATF4/ZFP36/RAN/HLA-DRB5/HLA-DPA1/HLA-DPB1/SLC25A5/TNFRSF1A/HLA-G/PPP3R1/ATF2	2.00921470906728
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	14/382	205/9376	1.67620993487422	HLA-A/GTF2B/DDX3X/RHOA/CDC42/PMAIP1/HNRNPK/ATF4/IL6ST/YWHAZ/HDAC5/HLA-G/YWHAQ/ATF2	2.01739531984886
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	15/382	227/9376	1.62188343289434	CALR/HLA-A/B2M/PRKCB/CALM2/CALM3/RHOA/ATF4/TNFRSF1A/HLA-G/GSK3B/PPP3R1/CYCS/ATF2/GNG11	1.95468139868099
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/382	115/9376	1.92087411791486	JUND/PDE4D/PRKCB/RHOA/MEF2C/ATF4/NACA/WNK1/ATF2	2.04767544766025
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/382	173/9376	1.70250885210181	PRKCB/OAS1/CALCOCO2/HLA-DRB5/DNAJB1/ACTG1/HLA-DPA1/HLA-DPB1/SLC25A5/TNFRSF1A/DNAJC3/CYCS	1.92198953923915
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/382	253/9376	1.55222150942615	UBB/UBC/MYL12A/RHOA/CDC42/SKP1/CALCOCO2/ARPC5/ARPC3/ACTG1/MYL12B/TNFRSF1A/CBX3/GSK3B/CYCS/SEPTIN2	1.8350403571137
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/382	67/9376	2.19801515980308	PRKCB/CALM2/CALM3/ATF4/GRIN2D/PPP3R1	2.02809865920206
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/382	52/9376	2.36004832863472	LDLR/CD36/NPC2/VAPA/LIPA	2.02672935818713
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/382	122/9376	1.81066002918204	THRB/PRKCB/ATP2A2/NOTCH2/ACTG1/NCOA3/GSK3B/MED13L/MED13	1.85735451477438
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/382	23/9376	3.20145686319144	CTSA/PRCP/ATP6AP2	2.17840943285913
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/382	106/9376	1.85241529190951	HSP90AA1/HSP90AB1/GSTP1/HSP90B1/ATF4/PDGFB/SLC46A1/GSK3B	1.8188847249042
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/382	54/9376	2.27263913127787	HLA-A/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-G	1.93280696299696
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/382	89/9376	1.9304664980293	PRKCB/TUBA1B/TUBB6/TUBB4B/TUBA1A/HTR2B/PDGFB	1.81760244953638
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/382	55/9376	2.2313184198001	HEXB/PLPP3/ASAH1/NEU1/GLA	1.88738867634902
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/382	75/9376	1.96356020942408	PRKCB/CANX/HSP90B1/ATF4/GPX3/ATF2	1.72657538425603
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/382	170/9376	1.58817369879889	YBX3/TUBA1B/MYL12A/RHOA/CDC42/TUBA1A/EZR/ARPC5/ARPC3/ACTG1/MYL12B	1.59490732931678
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/382	94/9376	1.82778210983625	HSP90AA1/JUND/HSP90AB1/HSP90B1/FOSB/CEBPB/GSK3B	1.66226422791035
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/382	76/9376	1.93772389087903	SHC2/PRKCB/CALM2/CALM3/PDGFB/GADD45B	1.69153574968725
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/382	133/9376	1.66090619218203	KLF2/GABARAP/HOMER1/CAT/INSR/HOMER3/GADD45B/STK4/PLK2	1.58197655486777
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/382	133/9376	1.66090619218203	PRKCB/CALM2/CALM3/PPP2R3A/ATF4/PPP2R5C/GSK3B/ATF2/GNG11	1.58197655486777
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/382	60/9376	2.04537521815009	SHC2/PRKCB/CDC42/HSPB1/PPP3R1	1.67407134907385
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/382	78/9376	1.88803866290777	HSPD1/TOB2/CNOT1/TOB1/HSPA9/DDX6	1.62302527374287
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/382	194/9376	1.5182166567712	DYNLL1/TUBA1B/TUBB6/TUBB4B/MYL12A/TUBA1A/CAPZA2/KIF16B/ACTG1/MYL12B/MYO1D/DYNLRB1	1.50308820548349
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/382	61/9376	2.01184447686894	FTL/FTH1/HMOX1/TRPM7/SLC46A1	1.63391000218413
NA	NA	hsa04517	IgSF CAM signaling	17/382	299/9376	1.3955068378014	DYNLL1/PRKCB/TUBA1B/TUBB6/TUBB4B/MYL12A/RHOA/CDC42/TUBA1A/EZR/ARPC5/ARPC3/ACTG1/MYL12B/DOK2/GSK3B/RASA1	1.43238347081254
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/382	98/9376	1.75317875841436	LDLR/PRKCB/CALM2/CALM3/ATF4/NR4A1/ATF2	1.54463117219653
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/382	157/9376	1.56334411578351	HLA-A/CALM2/CALM3/GADD45B/IGFBP3/TRPM7/SLC25A5/HLA-G/HIPK1/PPP3R1	1.46697448131549
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/382	157/9376	1.56334411578351	DDIT3/CDC42/ATF4/INSR/ERN1/MT-CO1/TNFRSF1A/GSK3B/NDUFC2/CYCS	1.46697448131549
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/382	138/9376	1.60072843159572	ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/MT-CO1/ATP6V1B2/ATP6V1A/NDUFC2/CYCS	1.46510796451477
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/382	138/9376	1.60072843159572	CALM2/CALM3/SKP1/SPDYE2/PPP2R5C/CPEB4/YWHAZ/YWHAQ/PPP3R1	1.46510796451477
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/382	29/9376	2.53908647770356	CALM2/CALM3/CNGA1	1.71067212283395
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/382	46/9376	2.13430457546096	FTL/FTH1/HMOX1/BLVRB	1.58931014606972
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/382	31/9376	2.37527444688397	CAT/SHMT1/MDH1	1.58059806455905
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	18/382	333/9376	1.32672987123249	HLA-A/FN1/ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/CDC42/PPP2R3A/PPP2R5C/NOTCH2/ITGB5/ATP6V1B2/TNFRSF1A/LAMB2/ATP6V1A/HLA-G/GSK3B/SPP1	1.25111021777501
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/382	105/9376	1.63630017452007	UBB/CCZ1B/UBC/GABARAP/ATF4/CALCOCO2/HUWE1	1.35124555830137
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/382	16/9376	3.06806282722513	HEXB/GLA	1.70618717591351
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/382	49/9376	2.00363286675927	ATF4/FOSB/GRIN2D/ATF2	1.45158611294256
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/382	32/9376	2.30104712041885	PMAIP1/TNFRSF1A/CYCS	1.51929629282987
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/382	33/9376	2.2313184198001	SNAP23/STX7/VAMP5	1.46024272037514
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/382	169/9376	1.45233743300598	UBB/UBC/GABARAP/WDFY3/CALCOCO2/ERN1/UVRAG/STX7/LAMP1/SMCR8	1.22289082852109
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/382	362/9376	1.28824737496746	HSP90AA1/HSP90AB1/FN1/HSP90B1/PPP2R3A/ATF4/PPP2R5C/INSR/NR4A1/PDGFB/EIF4B/ITGB5/YWHAZ/LAMB2/GSK3B/YWHAQ/SPP1/ATF2/GNG11	1.15266139332821
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/382	109/9376	1.57625246169365	HSP90AA1/HSP90AB1/IL6ST/HLA-DRB5/HLA-DPA1/HLA-DPB1/PPP3R1	1.24708868595242
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/382	18/9376	2.72716695753345	PRDX1/ABCD4	1.51154099762921
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/382	73/9376	1.68113031628774	BST2/RAN/PPIA/CPSF7/SERINC3	1.20398481152562
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/382	93/9376	1.58351629792265	MYL12A/RHOA/CDC42/INSR/ACTG1/MYL12B	1.16544334888135
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/382	93/9376	1.58351629792265	NOTCH2/MAF/HLA-DRB5/HLA-DPA1/HLA-DPB1/PPP3R1	1.16544334888135
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/382	93/9376	1.58351629792265	KCNMA1/PRKCB/CALM2/CALM3/SLC12A2/LYZ	1.16544334888135
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/382	156/9376	1.41602899718083	LDLR/PIAS1/OAS1/EIF3E/YWHAZ/TNFRSF1A/GSK3B/YWHAQ/CYCS	1.07984474375319
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/382	75/9376	1.63630017452007	PMAIP1/GADD45B/IGFBP3/PPM1D/CYCS	1.14016769017559
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	16/382	308/9376	1.27503909702863	CLTC/TUBA1B/TUBB6/TUBB4B/CLTA/TUBA1A/PSMA2/ERN1/SOD1/PSMB3/MT-CO1/GPX3/SLC25A5/PSMB1/NDUFC2/CYCS	1.01147444345734
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/382	136/9376	1.44379427163536	HSPA1B/HSPA1A/HSPA8/OAS1/HSPA6/GSK3B/RACK1/CYCS	1.07437535814203
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/382	157/9376	1.40700970420516	CD36/CALR/AXL/ANO5/ATP2A2/ODC1/ITGB5/CEBPB/LIPA	1.05987234620586
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/382	56/9376	1.75317875841436	MAN2A1/STT3B/MAN1A1/OSTC	1.16499751410699
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/382	116/9376	1.48113377866041	PRKCB/MYL12A/RHOA/CDC42/EZR/ACTG1/MYL12B	1.07455890490592
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/382	116/9376	1.48113377866041	PRKCB/SLC38A2/HOMER1/HOMER3/GRIN2D/PPP3R1/GNG11	1.07455890490592
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/382	76/9376	1.61476990906586	PRKCB/CALM2/CALM3/EZR/ACTG1	1.10896745740589
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/382	201/9376	1.34323148654633	NUPR1/DDIT3/MEF2C/MAF/LYL1/FUS/NR4A3/GADD45B/IGFBP3/JUP/CEBPB	1.01373161643641
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/382	38/9376	1.93772389087903	HEXB/NAGK/RENBP	1.19366022457805
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/382	38/9376	1.93772389087903	PRKCB/INSR/NR3C2	1.19366022457805
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/382	138/9376	1.42286971697397	FN1/SKAP2/RHOA/CDC42/ARPC5/ARPC3/ACTG1/GSK3B	1.03133089380331
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/382	98/9376	1.50272465006945	PRKCB/CALM2/CALM3/IP6K1/DGKD/PIP4P1	1.030995838443
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/382	21/9376	2.33757167788581	DPYD/VNN1	1.26457820887529
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	11/382	204/9376	1.32347808233241	CD63/FN1/PRKCB/DCN/RHOA/CDC42/LUM/EZR/EIF4B/ITGB5/ACTG1	0.962650849811997
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/382	78/9376	1.57336555242314	PRKCB/EEF1A1/HLA-DRB5/HLA-DPA1/HLA-DPB1	1.04791246321328
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/382	120/9376	1.43176265270506	SHC2/CALM2/CALM3/RHOA/CDC42/ATF4/GSK3B	0.980990725348031
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/382	100/9376	1.47267015706806	CD36/CD37/CD59/HLA-DRB5/HLA-DPA1/HLA-DPB1	0.979306622070235
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/382	80/9376	1.53403141361257	SHC2/PRKCB/AXL/PDGFB/GSK3B	0.988563607531113
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/382	232/9376	1.26954323885178	FN1/MYL12A/RHOA/CDC42/EZR/TMSB4X/PDGFB/ARPC5/ARPC3/ITGB5/ACTG1/MYL12B	0.856732425570352
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/382	168/9376	1.31488406881077	HSP90AA1/HSP90AB1/FTL/FTH1/PPIA/TRPM7/CHMP5/SLC25A5/TNFRSF1A	0.848718271982035
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/382	83/9376	1.47858449504826	AUTS2/SKP1/RYBP/CBX6/CBX3	0.902527783390923
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/382	107/9376	1.37632724959632	CALM2/CALM3/ATF4/PPP4C/PPP3R1/ATF2	0.806829914924354
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/382	65/9376	1.51043093032622	LDLR/ATF4/NR4A1/ATF2	0.851013356422873
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/382	86/9376	1.42700596615122	LMNA/ATP2A2/ITGB5/ACTG1/JUP	0.819815621923134
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/382	45/9376	1.63630017452007	ABCC5/ABCD4/ABCA6	0.881749216760529
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/382	108/9376	1.36358347876672	SAP18/EEF1A1/SUMO2/RAN/SUMO1/RBM8A	0.78318413954813
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/382	87/9376	1.4106035987242	RHOA/PMAIP1/GADD45B/GSK3B/CYCS	0.792937166083248
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/382	66/9376	1.48754561320006	MAF/HLA-DRB5/HLA-DPA1/HLA-DPB1	0.819130804483478
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/382	109/9376	1.35107353859455	CD36/PRKCB/INSR/SLC27A3/TNFRSF1A/GSK3B	0.759770876521319
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/382	26/9376	1.88803866290777	ABCD4/SLC46A1	0.934444733795944
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/382	46/9376	1.60072843159572	PSMA2/PSMB3/PSMB1	0.841699673987155
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/382	154/9376	1.27503909702863	CALM2/CALM3/ATP2A2/PPP2R3A/ATF4/PPP2R5C/CREM/ATF2	0.709223492820031
NA	NA	hsa04518	Integrin signaling	8/382	154/9376	1.27503909702863	FN1/CDC42/PDGFB/ITGB5/ACTG1/LAMB2/GSK3B/SPP1	0.709223492820031
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/382	154/9376	1.27503909702863	PRKCB/CALM2/CALM3/RHOA/MEF2C/ACTG1/EEF2/PPP3R1	0.709223492820031
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/382	110/9376	1.33879105188006	DCN/RGMA/RHOA/SKP1/EMP3/SMAD5	0.736585226285295
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/382	89/9376	1.3789046414495	CD36/FN1/ITGB5/LAMB2/SPP1	0.740164214292458
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/382	178/9376	1.24101417730455	DKK2/PRKCB/CACYBP/RHOA/SKP1/DKK1/NOTUM/GSK3B/PPP3R1	0.669031808879916
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/382	27/9376	1.8181113050223	HACD2/SCP2	0.877308978891192
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/382	69/9376	1.42286971697397	KCNMA1/CALM2/CALM3/PPP3R1	0.726552751017122
NA	NA	hsa03272	Virion - Hepatitis viruses	3/382	48/9376	1.53403141361257	LDLR/CD63/LAMP1	0.764423504950282
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/382	158/9376	1.24275962621777	SKP1/PPP2R5C/GADD45B/YWHAZ/GSK3B/PDS5B/YWHAQ/NIPBL	0.634201886794469
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/382	28/9376	1.75317875841436	HACD2/PPT1	0.822542989311875
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	10/382	205/9376	1.19729281062444	CALR/HLA-A/B2M/OAS1/HLA-DRB5/GADD45B/HLA-DPA1/HLA-DPB1/HLA-G/CYCS	0.588600628690277
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	10/382	205/9376	1.19729281062444	CD36/PRKCB/ATP2A2/INSR/GAPDH/PDK4/MT-CO1/SLC25A5/GSK3B/NDUFC2	0.588600628690277
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/382	93/9376	1.31959691493554	PRKCB/CALM2/CALM3/CDC42/ATF4	0.638323385586052
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/382	50/9376	1.47267015706806	HLA-DRB5/HLA-DPA1/HLA-DPB1	0.690615558023203
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/382	116/9376	1.26954323885178	HIBCH/CAT/GAPDH/TPI1/SHMT1/MDH1	0.60199491370527
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/382	184/9376	1.20054632369679	RGMA/MYL12A/RHOA/CDC42/MYL12B/DPYSL2/GSK3B/PPP3R1/RASA1	0.566186469885341
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/382	140/9376	1.22722513089005	KLF2/CALM2/CALM3/MEF2C/HDAC5/SPP1/GNG11	0.558237871283169
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/382	97/9376	1.26518054730933	PRKCB/CALM2/CALM3/GRIN2D/GNG11	0.541025606345158
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/382	31/9376	1.58351629792265	HIBCH/DPYD	0.670633220318253
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/382	31/9376	1.58351629792265	SPCS2/SEC11A	0.670633220318253
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/382	53/9376	1.38931146893213	CLTC/PRKCB/CLTA	0.585730944618011
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/382	98/9376	1.25227054172454	PRKCB/CDC42/PLPP3/ARPC5/ARPC3	0.517360504689461
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/382	76/9376	1.29181592725269	CD36/UBC/FABP3/SCP2	0.526399165124537
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/382	191/9376	1.15654724377073	SHC2/CALM2/CALM3/ATF4/FOSB/GRIN2D/HDAC5/ATF2/GNG11	0.450467441632053
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	11/382	238/9376	1.13440978485635	SHC2/PRKCB/CALM2/CALM3/RHOA/CDC42/INSR/PDGFB/STK4/RASA1/GNG11	0.432847252969168
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/382	122/9376	1.20710668612136	RHOA/CDC42/PPP2R3A/PPP2R5C/GSK3B/PPP3R1	0.474515240248871
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/382	122/9376	1.20710668612136	SHC2/PRKCB/ATF4/IGFBP3/GSK3B/ATF2	0.474515240248871
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/382	125/9376	1.17813612565445	PRKCB/RHOA/PPP2R3A/PPP2R5C/ASAH1/TNFRSF1A	0.413193562379321
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/382	102/9376	1.20316189302946	KCNMA1/PRKCB/RHOA/ATP2A2/SLC12A2	0.425157328035984
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/382	103/9376	1.19148070960199	FN1/PRDX1/PRKCB/HSPB1/LAMB2	0.402693285964705
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/382	57/9376	1.29181592725269	HACD2/PPT1/SCP2	0.455410083042211
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/382	35/9376	1.40254300673149	HSD17B14/TPI1	0.49168900896622
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/382	133/9376	1.10727079478802	SHC2/ULBP2/HLA-A/PRKCB/HLA-G/PPP3R1	0.256768486033395
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/382	15/9376	1.63630017452007	HEXB	0.508261749821707
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/382	86/9376	1.14160477292098	KCNMA1/PRKCB/ATF4/ATF2	0.271869280951413
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/382	39/9376	1.25869244193852	DHFR/SHMT1	0.333620894561342
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/382	63/9376	1.16878583894291	HPGDS/PTGES3/GPX4	0.277014407956092
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/382	16/9376	1.53403141361257	MIF	0.440585042894122
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/382	89/9376	1.1031237131596	PRKCB/SLC38A2/GABARAP/GNG11	0.201445096670498
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/382	187/9376	1.05003219755299	HSP90AA1/HSP90AB1/TXNIP/GABARAP/RHOA/OAS1/TRPM7/ANTXR2	0.142422017738319
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/382	65/9376	1.13282319774466	PLPP3/GLA/DGKD	0.221448796708429
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/382	163/9376	1.05405839462949	PRKCB/DDX3X/ATF4/YWHAZ/YWHAQ/CYCS/ATF2	0.14348195615676
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/382	90/9376	1.09086678301338	CAT/ATF4/INSR/ATF2	0.178506052451709
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/382	17/9376	1.44379427163536	SCP2	0.37742642834186
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/382	17/9376	1.44379427163536	LAMP1	0.37742642834186
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/382	91/9376	1.0788792359473	PDE4D/PRKCB/PDE7B/GNG11	0.155823629323881
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/382	42/9376	1.16878583894291	CAT/AOC1	0.225926737885136
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/382	217/9376	1.01797476295027	HSP90AA1/HSP90AB1/PTGES3/KLF4/PRKCB/HSP90B1/ATF4/NOTCH2/ATF2	0.0552090007966352
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/382	43/9376	1.14160477292098	CD36/PLPP3	0.191797245087528
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/382	93/9376	1.05567753194843	FN1/GADD45B/LAMB2/CYCS	0.111203422290753
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/382	170/9376	1.01065599014475	SHC2/HMOX1/PRKCB/GSTP1/ACTG1/GADD45B/GSK3B	0.0288950641922509
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/382	19/9376	1.29181592725269	HEXB	0.262396692023577
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/382	70/9376	1.05190725504862	SULT1A1/HPGDS/GSTP1	0.0898331104204274
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/382	122/9376	1.00592223843447	CD36/PPP2R3A/PPP2R5C/INSR/EEF2	0.0135688154070338
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/382	20/9376	1.22722513089005	NPL	0.209636611634958
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/382	149/9376	0.988369232931586	SHC2/RHOA/PLPP3/INSR/PDGFB/DGKD	-0.0294925354462893
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/382	73/9376	1.00867818977265	PRKCB/GADD45B/STK4	0.0153398085916185
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/382	99/9376	0.991697075466709	PRKCB/CALM2/CALM3/HTR2B	-0.0171153501159798
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/382	99/9376	0.991697075466709	CFD/HLA-DRB5/HLA-DPA1/HLA-DPB1	-0.0171153501159798
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/382	99/9376	0.991697075466709	PRKCB/PLPP3/PDGFB/DGKD	-0.0171153501159798
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/382	99/9376	0.991697075466709	LMNA/ATP2A2/ITGB5/ACTG1	-0.0171153501159798
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/382	21/9376	1.16878583894291	CSGALNACT1	0.159574920299827
Organismal Systems	Immune system	hsa04611	Platelet activation	5/382	126/9376	0.973988199119089	MYL12A/RHOA/ACTG1/SNAP23/MYL12B	-0.0605795028683117
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/382	254/9376	0.966319000700829	PRKCB/CALM2/CALM3/ATP2A2/HTR2B/MCOLN1/PDGFB/GRIN2D/SLC25A5/PPP3R1	-0.112149584967421
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/382	101/9376	0.972059509615883	PRKCB/CALM2/CALM3/GSK3B	-0.0581806581752281
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/382	75/9376	0.981780104712042	GAPDH/TPI1/SHMT1	-0.0326476979852803
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/382	75/9376	0.981780104712042	GSTP1/PMAIP1/CYCS	-0.0326476979852803
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/382	22/9376	1.11565920990005	AOC1	0.111926714809812
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/382	128/9376	0.958769633507853	PDE4D/PDE7B/APRT/NUDT2/AK6	-0.0967919295324515
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/382	50/9376	0.981780104712042	CD36/GYPC	-0.0266209807479038
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/382	23/9376	1.06715228773048	MDH1	0.0664492588867173
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/382	78/9376	0.944019331453887	CALM2/CALM3/RHOA	-0.102313157845923
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/382	105/9376	0.935028671154326	CALM2/CALM3/RHOA/PPP3R1	-0.137972961559963
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/382	105/9376	0.935028671154326	LMNA/ATP2A2/ITGB5/ACTG1	-0.137972961559963
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/382	52/9376	0.944019331453887	LDLR/INSR	-0.083421788803083
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/382	212/9376	0.926207645954756	PRKCB/CALM2/CALM3/RHOA/CDC42/INSR/PDGFB/ACTG1	-0.223963699769602
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/382	160/9376	0.920418848167539	HLA-A/HLA-DRB5/HLA-DPA1/HLA-DPB1/SIGLEC1/HLA-G	-0.209237661231228
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/382	134/9376	0.915839649917949	KCNMA1/PRKCB/CALM2/CALM3/RHOA	-0.202217077002873
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/382	54/9376	0.90905565251115	AMD1/MDH1	-0.138120747469994
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/382	110/9376	0.892527367920038	HMOX1/PRKCB/INSR/GAPDH	-0.233662467118881
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/382	110/9376	0.892527367920038	HSP90AA1/HSP90AB1/SPDYE2/CPEB4	-0.233662467118881
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/382	83/9376	0.887150697028954	PCBP1/G3BP1/POLR1D	-0.212814314549408
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/382	138/9376	0.889293573108734	SHC2/CALM2/CALM3/INSR/GSK3B	-0.270000318331066
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/382	86/9376	0.856203579690734	SHC2/PRKCB/GSK3B	-0.276077060020309
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/382	28/9376	0.87658937920718	B3GNT5	-0.13477616011565
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/382	28/9376	0.87658937920718	DHFR	-0.13477616011565
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/382	142/9376	0.864243049922572	JUND/ATP2A2/FOSB/TNFRSF1A/PPP3R1	-0.335932628167448
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/382	59/9376	0.832017037891561	DPYD/NUDT2	-0.266743638713123
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/382	59/9376	0.832017037891561	GADD45B/GSK3B	-0.266743638713123
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/382	29/9376	0.846362159234519	MOB1A	-0.170766214255917
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/382	30/9376	0.818150087260035	MDH1	-0.205589871008553
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/382	119/9376	0.825025298077346	ATF4/CEBPB/TNFRSF1A/ATF2	-0.39587173018588
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/382	91/9376	0.809159426960474	PRKCB/GSK3B/PPP3R1	-0.376999984294176
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/382	31/9376	0.791758148961324	HSD17B14	-0.239331623922549
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/382	148/9376	0.829206169520306	SHC2/NOTCH2/GADD45B/NCOA3/GSK3B	-0.431608631783045
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/382	63/9376	0.779190559295271	ERCC5/CUL4B	-0.362396495292633
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/382	63/9376	0.779190559295271	GADD45B/GSK3B	-0.362396495292633
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/382	32/9376	0.767015706806283	GLA	-0.272067142981606
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/382	32/9376	0.767015706806283	HIBCH	-0.272067142981606
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/382	32/9376	0.767015706806283	GABARAP	-0.272067142981606
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/382	65/9376	0.755215465163109	PRKCB/SPP1	-0.408115763006014
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/382	34/9376	0.721897135817678	POLR1D	-0.334784904046059
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/382	34/9376	0.721897135817678	SKP1	-0.334784904046059
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/382	155/9376	0.791758148961324	LDLR/ATF4/NR4A1/GSK3B/ATF2	-0.538748075288929
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/382	67/9376	0.73267171993436	GAPDH/TPI1	-0.452555313621438
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/382	68/9376	0.721897135817678	ALDH1A1/DHRS4	-0.474321279399952
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/382	157/9376	0.781672057891753	MOB1A/ACTG1/YWHAZ/GSK3B/YWHAQ	-0.568536194232671
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/382	99/9376	0.743772806600032	SHC2/NOTCH2/NCOA3	-0.528177524279752
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/382	36/9376	0.681791739383362	GBE1	-0.394212272021966
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/382	100/9376	0.736335078534031	IL6ST/TNFRSF1A/TNFRSF14	-0.546276932736565
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/382	130/9376	0.755215465163109	SHC2/ATF4/ATF2/GNG11	-0.579188040741706
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/382	70/9376	0.701271503365744	CD36/TNFRSF1A	-0.516993433745226
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/382	70/9376	0.701271503365744	CDC42/PDGFB	-0.516993433745226
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/382	101/9376	0.729044632211912	FN1/PRKCB/CDC42	-0.56421205989224
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/382	37/9376	0.663364935616245	MIF	-0.422815503270539
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/382	37/9376	0.663364935616245	NAGK	-0.422815503270539
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/382	37/9376	0.663364935616245	PRKCB	-0.422815503270539
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/382	37/9376	0.663364935616245	GADD45B	-0.422815503270539
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/382	71/9376	0.691394439938058	SHC2/GSK3B	-0.537917421560498
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/382	103/9376	0.714888425761196	SLC38A2/PRCP/SLC3A2	-0.599603568084956
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/382	73/9376	0.672452126515097	HPGDS/GSTP1	-0.578982692875382
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/382	73/9376	0.672452126515097	PDGFB/GADD45B	-0.578982692875382
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/382	193/9376	0.763041532159618	SHC2/PRKCB/RHOA/CDC42/GSK3B/GNG11	-0.685487395347096
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/382	105/9376	0.701271503365744	PRKCB/GADD45B/TNFRSF1A	-0.634379134847074
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/382	41/9376	0.598646405312221	SHMT1	-0.530765642423868
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/382	41/9376	0.598646405312221	GRIN2D	-0.530765642423868
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/382	226/9376	0.760227957188528	PDE4D/CALM2/CALM3/RHOA/ATP2A2/GRIN2D/CNGA1	-0.751939837116833
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/382	227/9376	0.756878935350693	HMOX1/AS3MT/CAT/SOD1/MT-CO1/SLC25A5/NDUFC2	-0.764169292122402
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/382	77/9376	0.637519548514313	CDC42/GADD45B	-0.658192162951639
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/382	77/9376	0.637519548514313	SHC2/GADD45B	-0.658192162951639
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/382	78/9376	0.629346220969258	TPI1/IP6K1	-0.677425968375521
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/382	79/9376	0.621379813108887	HPGDS/GSTP1	-0.696444918107688
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/382	44/9376	0.557829604950024	GTF2B	-0.605856138939018
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/382	44/9376	0.557829604950024	MBD4	-0.605856138939018
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/382	44/9376	0.557829604950024	DYNLL1	-0.605856138939018
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/382	233/9376	0.737388490663551	FN1/DCN/LMNA/CAPZA2/ITGB5/ACTG1/JUP	-0.836542932485027
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/382	144/9376	0.681791739383362	KLF4/IL6ST/SMAD5/GSK3B	-0.793022803723063
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/382	82/9376	0.598646405312221	DPYD/GSTP1	-0.752269799770593
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/382	115/9376	0.640291372638288	PRKCB/ATF4/GNG11	-0.799855822018274
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/382	115/9376	0.640291372638288	PRKCB/HTR2B/GNG11	-0.799855822018274
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/382	47/9376	0.522223459953214	MDH1	-0.676701410200937
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/382	47/9376	0.522223459953214	INSR	-0.676701410200937
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/382	117/9376	0.629346220969258	MORF4L2/ACTG1/MORF4L1	-0.831419486705942
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/382	48/9376	0.511343804537522	HIBCH	-0.699472488189801
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/382	48/9376	0.511343804537522	PRKCB	-0.699472488189801
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/382	150/9376	0.654520069808028	SHC2/GADD45B/JUP/GSK3B	-0.879027790650523
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/382	85/9376	0.577517708654142	APRT/AK6	-0.806357483365703
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/382	87/9376	0.564241439489679	ATP2A2/MT-CO1	-0.841515172154302
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/382	88/9376	0.557829604950024	CFD/CD59	-0.858837051624497
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/382	51/9376	0.481264757211785	PLPP3	-0.765503711588394
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/382	56/9376	0.43829468960359	GSK3B	-0.868831313897068
NA	NA	hsa04519	Cadherin signaling	12/382	404/9376	0.729044632211912	RHOA/CDC42/TAOK1/ARPC5/ARPC3/MOB1A/ACTG1/MYO1D/YWHAZ/JUP/GSK3B/YWHAQ	-1.14732032485178
NA	NA	hsa04082	Neuroactive ligand signaling	5/382	199/9376	0.616696045673393	PRKCB/HTR2B/GRIN2D/P2RY14/GNG11	-1.12631625017243
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/382	59/9376	0.41600851894578	INSR	-0.927332216783445
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/382	323/9376	0.683902549722011	HMOX1/PRKCB/STMN1/RHOA/HNRNPK/NOTCH2/EZR/PDGFB/HDAC5	-1.19142544707147
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/382	60/9376	0.409075043630017	PRKCB	-0.946311450411362
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/382	62/9376	0.395879074480662	NOTCH2	-0.983541037087673
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/382	103/9376	0.476592283840797	CALR/TNFRSF1A	-1.10075199510979
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/382	104/9376	0.472009665726943	PLPP3/DGKD	-1.11582685198806
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/382	143/9376	0.514919635338484	HLA-DRB5/HLA-DPA1/HLA-DPB1	-1.20462306498011
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/382	144/9376	0.511343804537522	TRA2A/TNFRSF1A/GSK3B	-1.21780467116522
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/382	68/9376	0.360948567908839	JUP	-1.08994092442403
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/382	183/9376	0.536491860498384	PWP2/RAN/AK6/EIF6	-1.30495386462045
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/382	149/9376	0.494184616465793	PRKCB/NDUFC2/GNG11	-1.28261343730917
NA	NA	hsa04081	Hormone signaling	5/382	219/9376	0.560376772095914	THRB/RHOA/INSR/SMAD5/GNG11	-1.35664731328042
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/382	72/9376	0.340895869691681	DDX3X	-1.15698121729837
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/382	154/9376	0.478139661385735	DHFR/AK6/SHMT1	-1.34568363594406
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/382	195/9376	0.503476976775406	PRKCB/ACTG1/SLC25A5/HDAC5	-1.44395141638487
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/382	168/9376	0.43829468960359	PIAS1/IL6ST/PDGFB	-1.51398437591095
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/382	86/9376	0.285401193230245	SCN9A	-1.37196974196375
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/382	90/9376	0.272716695753345	LDLR	-1.42873410227353
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/382	90/9376	0.272716695753345	PPP3R1	-1.42873410227353
NA	NA	hsa04382	Cornified envelope formation	4/382	217/9376	0.452433227977899	S100A4/PPP2R3A/PPP2R5C/JUP	-1.68183660816058
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	4/382	235/9376	0.417778767962571	ACTG1/MT-CO1/NDUFC2/ATF2	-1.86279898938017
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/382	109/9376	0.225178923099092	SPP1	-1.67681817063421
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	3/382	298/9376	0.247092308232896	IL6ST/TNFRSF1A/TNFRSF14	-2.7220472205254
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/382	370/9376	0.265345974246498	THRB/HTR2B/GRIN2D/P2RY14	-2.9713829809821
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/382	449/9376	0.10932963304143	CALM2/CALM3	-3.98591730756135