ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0051082 unfolded protein binding 33/626 121/18639 0.272727272727273 8.12038919546907 3.17370179025035e-21 3.07849073654284e-18 GO:0044183 protein folding chaperone 21/626 75/18639 0.28 8.33693290734824 3.09832966839096e-14 1.50268988916962e-11 GO:0140662 ATP-dependent protein folding chaperone 16/626 40/18639 0.4 11.9099041533546 6.44840111519088e-14 2.08498302724505e-11 GO:0031625 ubiquitin protein ligase binding 40/626 302/18639 0.132450331125828 3.94367687197173 1.14550550051798e-13 2.7778508387561e-11 GO:0044389 ubiquitin-like protein ligase binding 41/626 322/18639 0.127329192546584 3.79119619788463 2.13212480293887e-13 4.13632211770141e-11 GO:0045296 cadherin binding 37/626 334/18639 0.110778443113772 3.2984015993572 1.98323650511252e-10 3.2062323499319e-08 GO:0031072 heat shock protein binding 20/626 131/18639 0.152671755725191 4.54576494402849 1.49437658630147e-08 2.0707789838749e-06 GO:0051087 protein-folding chaperone binding 18/626 134/18639 0.134328358208955 3.99959467836536 5.64073658483786e-07 6.83939310911591e-05 GO:0004601 peroxidase activity 11/626 57/18639 0.192982456140351 5.74600638977636 2.5423747651208e-06 0.000257357694862198 GO:0097718 disordered domain specific binding 8/626 28/18639 0.285714285714286 8.50707439525331 2.65317211198142e-06 0.000257357694862198 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/626 59/18639 0.186440677966102 5.55122651215682 3.62852181974712e-06 0.000301290201819793 GO:0008135 translation factor activity, RNA binding 13/626 83/18639 0.156626506024096 4.66351668655452 3.72730146581187e-06 0.000301290201819793 GO:0180051 translation factor activity 13/626 84/18639 0.154761904761905 4.60799863076221 4.2762839647826e-06 0.000319076572756855 GO:0016887 ATP hydrolysis activity 33/626 417/18639 0.079136690647482 2.35627600156297 5.09530963267656e-06 0.000353032167406876 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 28/626 349/18639 0.0802292263610315 2.3888059906442 2.0491979431356e-05 0.00132514800322769 GO:0023026 MHC class II protein complex binding 7/626 27/18639 0.259259259259259 7.71938232161874 2.30258966412458e-05 0.00139594498387553 GO:0016209 antioxidant activity 12/626 86/18639 0.13953488372093 4.15461772791441 2.92706939219771e-05 0.00167015135907752 GO:0003725 double-stranded RNA binding 11/626 75/18639 0.146666666666667 4.36696485623003 3.90518276866873e-05 0.00210445960311593 GO:0031994 insulin-like growth factor I binding 5/626 13/18639 0.384615384615385 11.4518309166871 4.32546217427789e-05 0.00214463433319482 GO:0003743 translation initiation factor activity 9/626 51/18639 0.176470588235294 5.25436947942116 4.4219264601955e-05 0.00214463433319482 GO:0140297 DNA-binding transcription factor binding 34/626 488/18639 0.069672131147541 2.07447101031792 5.21504575343259e-05 0.00240885446706172 GO:0019888 protein phosphatase regulator activity 13/626 107/18639 0.121495327102804 3.61749425218715 6.11313028300205e-05 0.00269533471568727 GO:0044548 S100 protein binding 5/626 14/18639 0.357142857142857 10.6338429940666 6.54281130302126e-05 0.00275935954953505 GO:0048156 tau protein binding 8/626 43/18639 0.186046511627907 5.53949030388588 7.93621798748367e-05 0.00320755476994132 GO:0003735 structural constituent of ribosome 17/626 175/18639 0.0971428571428571 2.89240529438613 8.77616113368058e-05 0.00340515051986806 GO:0042625 ATPase-coupled ion transmembrane transporter activity 6/626 24/18639 0.25 7.44369009584665 0.000112407801367535 0.00389412740451817 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 6/626 24/18639 0.25 7.44369009584665 0.000112407801367535 0.00389412740451817 GO:0046961 proton-transporting ATPase activity, rotational mechanism 6/626 24/18639 0.25 7.44369009584665 0.000112407801367535 0.00389412740451817 GO:0019208 phosphatase regulator activity 13/626 117/18639 0.111111111111111 3.30830670926518 0.000153869466122213 0.00514666834960506 GO:0023023 MHC protein complex binding 7/626 37/18639 0.189189189189189 5.6330627752353 0.000199424900728268 0.00644807179021399 GO:0016922 nuclear receptor binding 14/626 137/18639 0.102189781021898 3.04267624355775 0.00021275915303423 0.00654366532120325 GO:0003697 single-stranded DNA binding 13/626 121/18639 0.107438016528926 3.19894119821509 0.000215873495132478 0.00654366532120325 GO:0008140 cAMP response element binding protein binding 4/626 10/18639 0.4 11.9099041533546 0.000225147675704625 0.00661797713434807 GO:0042277 peptide binding 20/626 249/18639 0.0803212851405622 2.39154701874591 0.00029866371877862 0.00848295091891354 GO:0019843 rRNA binding 9/626 65/18639 0.138461538461538 4.12265913000737 0.000306085857898942 0.00848295091891354 GO:0005520 insulin-like growth factor binding 5/626 19/18639 0.263157894736842 7.83546325878594 0.000330513324357936 0.00890549790631104 GO:0043024 ribosomal small subunit binding 5/626 20/18639 0.25 7.44369009584665 0.000428583302048419 0.0112358325131613 GO:0072542 protein phosphatase activator activity 5/626 21/18639 0.238095238095238 7.08922866271109 0.000547082110958228 0.0139649907270916 GO:0015631 tubulin binding 26/626 385/18639 0.0675324675324675 2.01076303887805 0.000619441428565676 0.0154066201463771 GO:0042605 peptide antigen binding 7/626 45/18639 0.155555555555556 4.63162939297125 0.000696855158797468 0.0168987376008386 GO:0019207 kinase regulator activity 21/626 287/18639 0.0731707317073171 2.17864100366243 0.000734439126149908 0.0173757549357417 GO:0070063 RNA polymerase binding 8/626 59/18639 0.135593220338983 4.03725564520496 0.000757671685402042 0.0174986079723805 GO:0048027 mRNA 5'-UTR binding 5/626 24/18639 0.208333333333333 6.2030750798722 0.00105137163281066 0.0237169879959615 GO:0060590 ATPase regulator activity 7/626 49/18639 0.142857142857143 4.25353719762665 0.00117494256033425 0.0259021428073687 GO:0019211 phosphatase activator activity 5/626 25/18639 0.2 5.95495207667732 0.00127828158692009 0.0264130453598455 GO:0031386 protein tag activity 4/626 15/18639 0.266666666666667 7.93993610223642 0.00127980735248736 0.0264130453598455 GO:0141047 molecular tag activity 4/626 15/18639 0.266666666666667 7.93993610223642 0.00127980735248736 0.0264130453598455 GO:0043022 ribosome binding 11/626 112/18639 0.0982142857142857 2.92430682336832 0.00136945632090534 0.0276744298182955 GO:0050750 low-density lipoprotein particle receptor binding 5/626 26/18639 0.192307692307692 5.72591545834357 0.00153940038154797 0.0301570441660995 GO:0001618 virus receptor activity 9/626 81/18639 0.111111111111111 3.30830670926518 0.00155448681268554 0.0301570441660995 GO:0042626 ATPase-coupled transmembrane transporter activity 10/626 98/18639 0.102040816326531 3.03824085544761 0.00167390804826537 0.0316237721061542 GO:0140272 exogenous protein binding 9/626 82/18639 0.109756097560976 3.26796150549365 0.00169529499950517 0.0316237721061542 GO:0001671 ATPase activator activity 5/626 27/18639 0.185185185185185 5.51384451544196 0.00183769942761197 0.0336333668827097 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 7/626 54/18639 0.12962962962963 3.85969116080937 0.00209687942775798 0.036899577614921 GO:1990226 histone methyltransferase binding 4/626 17/18639 0.235294117647059 7.00582597256155 0.00211539410491639 0.036899577614921 GO:0044325 transmembrane transporter binding 12/626 136/18639 0.0882352941176471 2.62718473971058 0.00213028489323255 0.036899577614921 GO:0019887 protein kinase regulator activity 18/626 255/18639 0.0705882352941176 2.10174779176846 0.0025302143845367 0.0421114258870579 GO:0043175 RNA polymerase core enzyme binding 6/626 42/18639 0.142857142857143 4.25353719762665 0.00262484967999059 0.0421114258870579 GO:0048487 beta-tubulin binding 6/626 42/18639 0.142857142857143 4.25353719762665 0.00262484967999059 0.0421114258870579 GO:0051879 Hsp90 protein binding 6/626 42/18639 0.142857142857143 4.25353719762665 0.00262484967999059 0.0421114258870579 GO:0000900 mRNA regulatory element binding translation repressor activity 4/626 18/18639 0.222222222222222 6.61661341853035 0.00264824430836137 0.0421114258870579 GO:0003712 transcription coregulator activity 29/626 495/18639 0.0585858585858586 1.74437990124891 0.00276743501098599 0.0432969671073615 GO:0003727 single-stranded RNA binding 9/626 89/18639 0.101123595505618 3.01093082528628 0.00299103587299152 0.0460524570920917 GO:0030547 signaling receptor inhibitor activity 6/626 44/18639 0.136363636363636 4.06019459773453 0.00333805511237957 0.0505923977970028 GO:0070325 lipoprotein particle receptor binding 5/626 31/18639 0.161290322580645 4.80238070699784 0.00346335964997728 0.0516839824688917 GO:0042826 histone deacetylase binding 11/626 127/18639 0.0866141732283465 2.57891625367915 0.00370350093531572 0.0537641005804363 GO:0005528 FK506 binding 3/626 10/18639 0.3 8.93242811501597 0.00379161924309576 0.0537641005804363 GO:0035256 G protein-coupled glutamate receptor binding 3/626 10/18639 0.3 8.93242811501597 0.00379161924309576 0.0537641005804363 GO:0003714 transcription corepressor activity 15/626 204/18639 0.0735294117647059 2.18932061642548 0.00382445663922691 0.0537641005804363 GO:0003724 RNA helicase activity 8/626 77/18639 0.103896103896104 3.09348159827393 0.00424942951963425 0.0588849519149318 GO:0016247 channel regulator activity 13/626 168/18639 0.0773809523809524 2.3039993153811 0.00447249046331046 0.0611030387241007 GO:0141108 transporter regulator activity 13/626 170/18639 0.0764705882352941 2.2768934410825 0.00493908451366902 0.0640492159933096 GO:0008186 ATP-dependent activity, acting on RNA 8/626 79/18639 0.10126582278481 3.01516560844421 0.00497101935492334 0.0640492159933096 GO:0019902 phosphatase binding 14/626 190/18639 0.0736842105263158 2.19392971246006 0.00501229359417763 0.0640492159933096 GO:0008432 JUN kinase binding 3/626 11/18639 0.272727272727273 8.12038919546907 0.00508431920771633 0.0640492159933096 GO:0032050 clathrin heavy chain binding 3/626 11/18639 0.272727272727273 8.12038919546907 0.00508431920771633 0.0640492159933096 GO:0043522 leucine zipper domain binding 3/626 11/18639 0.272727272727273 8.12038919546907 0.00508431920771633 0.0640492159933096 GO:0140693 molecular condensate scaffold activity 6/626 48/18639 0.125 3.72184504792332 0.00518394005216099 0.0644669468025149 GO:0050321 tau-protein kinase activity 4/626 22/18639 0.181818181818182 5.41359279697938 0.00569223395258522 0.0690183366750957 GO:0140517 protein-RNA adaptor activity 4/626 22/18639 0.181818181818182 5.41359279697938 0.00569223395258522 0.0690183366750957 GO:0061631 ubiquitin conjugating enzyme activity 5/626 35/18639 0.142857142857143 4.25353719762665 0.00592764398300635 0.0709853662162489 GO:0038024 cargo receptor activity 7/626 65/18639 0.107692307692308 3.2065126566724 0.00600983168103456 0.0710919113488234 GO:0005527 macrolide binding 3/626 12/18639 0.25 7.44369009584665 0.00661144498905463 0.0723236335149828 GO:0035259 nuclear glucocorticoid receptor binding 3/626 12/18639 0.25 7.44369009584665 0.00661144498905463 0.0723236335149828 GO:0001540 amyloid-beta binding 8/626 83/18639 0.0963855421686747 2.86985642249509 0.00669177949190563 0.0723236335149828 GO:0000993 RNA polymerase II complex binding 5/626 36/18639 0.138888888888889 4.13538338658147 0.00669737970631438 0.0723236335149828 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/626 36/18639 0.138888888888889 4.13538338658147 0.00669737970631438 0.0723236335149828 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/626 36/18639 0.138888888888889 4.13538338658147 0.00669737970631438 0.0723236335149828 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/626 36/18639 0.138888888888889 4.13538338658147 0.00669737970631438 0.0723236335149828 GO:0004602 glutathione peroxidase activity 4/626 23/18639 0.173913043478261 5.17821919711071 0.00671044022303965 0.0723236335149828 GO:0043021 ribonucleoprotein complex binding 13/626 177/18639 0.0734463276836158 2.18684680781935 0.00688819625151738 0.0734236303733171 GO:1990841 promoter-specific chromatin binding 7/626 68/18639 0.102941176470588 3.06504886299568 0.00768057528679392 0.0809799785672838 GO:0099106 ion channel regulator activity 12/626 160/18639 0.075 2.23310702875399 0.00786433622586879 0.0814267790100442 GO:0016853 isomerase activity 13/626 180/18639 0.0722222222222222 2.15039936102236 0.00789084250200429 0.0814267790100442 GO:0016860 intramolecular oxidoreductase activity 6/626 53/18639 0.113207547169811 3.37072759057207 0.0084267859693824 0.0860419198979046 GO:0019903 protein phosphatase binding 11/626 144/18639 0.0763888888888889 2.27446086261981 0.00937942770046311 0.0941998418888198 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/626 39/18639 0.128205128205128 3.81727697222905 0.00942165284046989 0.0941998418888198 GO:0033218 amide binding 16/626 247/18639 0.0647773279352227 1.92872941754731 0.00951709742794262 0.0941998418888198 GO:0015078 proton transmembrane transporter activity 13/626 185/18639 0.0702702702702703 2.09228045937311 0.00981417085917202 0.0961590478120895 GO:0140313 molecular sequestering activity 6/626 55/18639 0.109090909090909 3.24815567818763 0.0100609118520922 0.0970559065757741 GO:0015399 primary active transmembrane transporter activity 12/626 166/18639 0.072289156626506 2.15239231687132 0.0103847495790234 0.0970559065757741 GO:0032036 myosin heavy chain binding 3/626 14/18639 0.214285714285714 6.38030579643998 0.0104059941070933 0.0970559065757741 GO:0098847 sequence-specific single stranded DNA binding 3/626 14/18639 0.214285714285714 6.38030579643998 0.0104059941070933 0.0970559065757741 GO:1990825 sequence-specific mRNA binding 3/626 14/18639 0.214285714285714 6.38030579643998 0.0104059941070933 0.0970559065757741 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 10/626 128/18639 0.078125 2.32615315495208 0.0111464766442242 0.102972212808548 GO:0019209 kinase activator activity 11/626 148/18639 0.0743243243243243 2.21298894741387 0.011381587258517 0.103701866740981 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 8/626 91/18639 0.0879120879120879 2.61756135238563 0.0114392780837989 0.103701866740981 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/626 41/18639 0.121951219512195 3.63106833943739 0.0116109752329993 0.104283759037123 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/626 15/18639 0.2 5.95495207667732 0.0126875407957448 0.110875181460528 GO:0140776 protein-containing complex destabilizing activity 3/626 15/18639 0.2 5.95495207667732 0.0126875407957448 0.110875181460528 GO:0016859 cis-trans isomerase activity 5/626 42/18639 0.119047619047619 3.54461433135554 0.0128253165239464 0.110875181460528 GO:0035198 miRNA binding 5/626 42/18639 0.119047619047619 3.54461433135554 0.0128253165239464 0.110875181460528 GO:0061980 regulatory RNA binding 6/626 58/18639 0.103448275862069 3.08014762586758 0.0129163871185975 0.110875181460528 GO:0017022 myosin binding 7/626 76/18639 0.0921052631578947 2.74241214057508 0.0137892540519122 0.116319784394381 GO:0004857 enzyme inhibitor activity 23/626 416/18639 0.0552884615384615 1.64620069427378 0.0137904899024266 0.116319784394381 GO:0036002 pre-mRNA binding 6/626 59/18639 0.101694915254237 3.02794173390372 0.0139826256609099 0.11692368009554 GO:0008200 ion channel inhibitor activity 5/626 43/18639 0.116279069767442 3.46218143992867 0.0141226649360202 0.117085341777261 GO:0030275 LRR domain binding 3/626 16/18639 0.1875 5.58276757188498 0.0152320318954682 0.12416025998827 GO:0034450 ubiquitin-ubiquitin ligase activity 3/626 16/18639 0.1875 5.58276757188498 0.0152320318954682 0.12416025998827 GO:0106222 lncRNA binding 4/626 29/18639 0.137931034482759 4.10686350115677 0.0153644972674922 0.124196352912229 GO:0016248 channel inhibitor activity 5/626 44/18639 0.113636363636364 3.38349549811211 0.0155053072211023 0.124298743838588 GO:0002020 protease binding 10/626 136/18639 0.0735294117647059 2.18932061642548 0.0165084223578138 0.131255489238355 GO:0003924 GTPase activity 19/626 331/18639 0.0574018126888218 1.70912521838171 0.0167646009672149 0.132208641773971 GO:0141110 transporter inhibitor activity 5/626 45/18639 0.111111111111111 3.30830670926518 0.016975421427893 0.132791603105292 GO:0022853 active monoatomic ion transmembrane transporter activity 9/626 118/18639 0.076271186440678 2.27095630042779 0.0180057868235119 0.137806754280632 GO:0030169 low-density lipoprotein particle binding 3/626 17/18639 0.176470588235294 5.25436947942116 0.0180427399934436 0.137806754280632 GO:0051787 misfolded protein binding 3/626 17/18639 0.176470588235294 5.25436947942116 0.0180427399934436 0.137806754280632 GO:0005507 copper ion binding 6/626 63/18639 0.0952380952380952 2.83569146508444 0.0188611185751899 0.142931914202611 GO:1990381 ubiquitin-specific protease binding 3/626 18/18639 0.166666666666667 4.96246006389776 0.02112163913046 0.158013437015342 GO:0051059 NF-kappaB binding 4/626 32/18639 0.125 3.72184504792332 0.0215028594701291 0.158013437015342 GO:0071813 lipoprotein particle binding 4/626 32/18639 0.125 3.72184504792332 0.0215028594701291 0.158013437015342 GO:0071814 protein-lipid complex binding 4/626 32/18639 0.125 3.72184504792332 0.0215028594701291 0.158013437015342 GO:0035254 glutamate receptor binding 5/626 49/18639 0.102040816326531 3.03824085544761 0.0237701275537945 0.171275069745793 GO:0140311 protein sequestering activity 4/626 33/18639 0.121212121212121 3.60906186465292 0.02383725197493 0.171275069745793 GO:0140416 transcription regulator inhibitor activity 4/626 33/18639 0.121212121212121 3.60906186465292 0.02383725197493 0.171275069745793 GO:0008017 microtubule binding 16/626 276/18639 0.0579710144927536 1.72607306570357 0.0246105547685591 0.175531162687517 GO:0030544 Hsp70 protein binding 5/626 51/18639 0.0980392156862745 2.91909415523398 0.0277403139266569 0.196409521962461 GO:0019001 guanyl nucleotide binding 21/626 400/18639 0.0525 1.5631749201278 0.0296921371543748 0.206194177912046 GO:0032561 guanyl ribonucleotide binding 21/626 400/18639 0.0525 1.5631749201278 0.0296921371543748 0.206194177912046 GO:0005080 protein kinase C binding 5/626 52/18639 0.0961538461538462 2.86295772917179 0.0298738086624152 0.206194177912046 GO:0097110 scaffold protein binding 6/626 70/18639 0.0857142857142857 2.55212231857599 0.029972555758349 0.206194177912046 GO:0005525 GTP binding 20/626 378/18639 0.0529100529100529 1.57538414726913 0.031031777931822 0.211977637984982 GO:0016798 hydrolase activity, acting on glycosyl bonds 9/626 130/18639 0.0692307692307692 2.06132956500369 0.0313173616999684 0.212432453489296 GO:0035613 RNA stem-loop binding 3/626 21/18639 0.142857142857143 4.25353719762665 0.0319699938098705 0.213868234452237 GO:0070182 DNA polymerase binding 3/626 21/18639 0.142857142857143 4.25353719762665 0.0319699938098705 0.213868234452237 GO:0072341 modified amino acid binding 7/626 91/18639 0.0769230769230769 2.29036618333743 0.0334040062206605 0.220875369950328 GO:1902936 phosphatidylinositol bisphosphate binding 8/626 111/18639 0.0720720720720721 2.14592867628011 0.0334728653429879 0.220875369950328 GO:0061775 cohesin loader activity 10/626 153/18639 0.065359477124183 1.94606277015599 0.0338884280359135 0.222106589154298 GO:0050661 NADP binding 5/626 54/18639 0.0925925925925926 2.75692225772098 0.0344435724282306 0.224229968156938 GO:0005200 structural constituent of cytoskeleton 8/626 112/18639 0.0714285714285714 2.12676859881333 0.0350340902975526 0.226553783924174 GO:0043539 protein serine/threonine kinase activator activity 6/626 73/18639 0.0821917808219178 2.44724057945643 0.0358191783892984 0.230096708858407 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/626 22/18639 0.136363636363636 4.06019459773453 0.0361191137873366 0.230496976142871 GO:0042162 telomeric DNA binding 4/626 38/18639 0.105263157894737 3.13418530351438 0.0377502050400642 0.239331365286681 GO:0019838 growth factor binding 9/626 136/18639 0.0661764705882353 1.97038855478294 0.0400451966036414 0.25222439542188 GO:0044013 histone H2B acetyltransferase activity 3/626 23/18639 0.130434782608696 3.88366439783303 0.0405304148219811 0.25222439542188 GO:0140104 molecular carrier activity 14/626 249/18639 0.0562248995983936 1.67408291312214 0.0422057406881475 0.25222439542188 GO:0004090 carbonyl reductase (NADPH) activity 2/626 10/18639 0.2 5.95495207667732 0.0423840994368727 0.25222439542188 GO:0005031 tumor necrosis factor receptor activity 2/626 10/18639 0.2 5.95495207667732 0.0423840994368727 0.25222439542188 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/626 10/18639 0.2 5.95495207667732 0.0423840994368727 0.25222439542188 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/626 10/18639 0.2 5.95495207667732 0.0423840994368727 0.25222439542188 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/626 10/18639 0.2 5.95495207667732 0.0423840994368727 0.25222439542188 GO:0030957 Tat protein binding 2/626 10/18639 0.2 5.95495207667732 0.0423840994368727 0.25222439542188 GO:0098505 G-rich strand telomeric DNA binding 2/626 10/18639 0.2 5.95495207667732 0.0423840994368727 0.25222439542188 GO:0030295 protein kinase activator activity 9/626 139/18639 0.0647482014388489 1.92786218309697 0.0449724588525541 0.265995640774253 GO:0001786 phosphatidylserine binding 5/626 59/18639 0.0847457627118644 2.5232847782531 0.0476746698243235 0.278580901985505 GO:0015459 potassium channel regulator activity 5/626 59/18639 0.0847457627118644 2.5232847782531 0.0476746698243235 0.278580901985505 GO:0001098 basal transcription machinery binding 5/626 60/18639 0.0833333333333333 2.48123003194888 0.0506352110765533 0.284119949729262 GO:0001099 basal RNA polymerase II transcription machinery binding 5/626 60/18639 0.0833333333333333 2.48123003194888 0.0506352110765533 0.284119949729262 GO:0008199 ferric iron binding 2/626 11/18639 0.181818181818182 5.41359279697938 0.0506729394877963 0.284119949729262 GO:0008526 phosphatidylinositol transfer activity 2/626 11/18639 0.181818181818182 5.41359279697938 0.0506729394877963 0.284119949729262 GO:0010854 adenylate cyclase regulator activity 2/626 11/18639 0.181818181818182 5.41359279697938 0.0506729394877963 0.284119949729262 GO:0019107 myristoyltransferase activity 2/626 11/18639 0.181818181818182 5.41359279697938 0.0506729394877963 0.284119949729262 GO:1990948 ubiquitin ligase inhibitor activity 2/626 11/18639 0.181818181818182 5.41359279697938 0.0506729394877963 0.284119949729262 GO:0003713 transcription coactivator activity 14/626 256/18639 0.0546875 1.62830720846645 0.051045189653573 0.284355325604533 GO:0031406 carboxylic acid binding 11/626 187/18639 0.0588235294117647 1.75145649314039 0.0513012185369003 0.284355325604533 GO:0042056 chemoattractant activity 4/626 42/18639 0.0952380952380952 2.83569146508444 0.0516143654296305 0.28446553674285 GO:0048306 calcium-dependent protein binding 6/626 80/18639 0.075 2.23310702875399 0.0521580050179175 0.285837654617966 GO:0043177 organic acid binding 11/626 189/18639 0.0582010582010582 1.73292256199604 0.0545768649390554 0.297413252757774 GO:0050681 nuclear androgen receptor binding 3/626 26/18639 0.115384615384615 3.43554927500614 0.0552967120528839 0.297987837173874 GO:0120014 phospholipid transfer activity 3/626 26/18639 0.115384615384615 3.43554927500614 0.0552967120528839 0.297987837173874 GO:0022804 active transmembrane transporter activity 22/626 457/18639 0.0481400437636762 1.4333582679092 0.0586482681692111 0.302097807517897 GO:0001046 core promoter sequence-specific DNA binding 4/626 44/18639 0.0909090909090909 2.70679639848969 0.0594551041266855 0.302097807517897 GO:0043014 alpha-tubulin binding 4/626 44/18639 0.0909090909090909 2.70679639848969 0.0594551041266855 0.302097807517897 GO:0004859 phospholipase inhibitor activity 2/626 12/18639 0.166666666666667 4.96246006389776 0.0594852383875446 0.302097807517897 GO:0005049 nuclear export signal receptor activity 2/626 12/18639 0.166666666666667 4.96246006389776 0.0594852383875446 0.302097807517897 GO:0008179 adenylate cyclase binding 2/626 12/18639 0.166666666666667 4.96246006389776 0.0594852383875446 0.302097807517897 GO:0010853 cyclase activator activity 2/626 12/18639 0.166666666666667 4.96246006389776 0.0594852383875446 0.302097807517897 GO:0035497 cAMP response element binding 2/626 12/18639 0.166666666666667 4.96246006389776 0.0594852383875446 0.302097807517897 GO:0043047 single-stranded telomeric DNA binding 2/626 12/18639 0.166666666666667 4.96246006389776 0.0594852383875446 0.302097807517897 GO:0070008 serine-type exopeptidase activity 2/626 12/18639 0.166666666666667 4.96246006389776 0.0594852383875446 0.302097807517897 GO:1990459 transferrin receptor binding 2/626 12/18639 0.166666666666667 4.96246006389776 0.0594852383875446 0.302097807517897 GO:0004860 protein kinase inhibitor activity 6/626 84/18639 0.0714285714285714 2.12676859881333 0.0632390804386497 0.319489104299428 GO:0019789 SUMO transferase activity 3/626 28/18639 0.107142857142857 3.19015289821999 0.0663667957084615 0.323851019300884 GO:0046966 nuclear thyroid hormone receptor binding 3/626 28/18639 0.107142857142857 3.19015289821999 0.0663667957084615 0.323851019300884 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 3/626 28/18639 0.107142857142857 3.19015289821999 0.0663667957084615 0.323851019300884 GO:0030276 clathrin binding 4/626 46/18639 0.0869565217391304 2.58910959855535 0.0678913101574644 0.323851019300884 GO:0000510 H3-H4 histone complex chaperone activity 9/626 151/18639 0.0596026490066225 1.77465459238728 0.0686529170227018 0.323851019300884 GO:0140584 chromatin extrusion motor activity 9/626 151/18639 0.0596026490066225 1.77465459238728 0.0686529170227018 0.323851019300884 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 9/626 151/18639 0.0596026490066225 1.77465459238728 0.0686529170227018 0.323851019300884 GO:0140849 ATP-dependent H2AZ histone chaperone activity 9/626 151/18639 0.0596026490066225 1.77465459238728 0.0686529170227018 0.323851019300884 GO:0005035 death receptor activity 2/626 13/18639 0.153846153846154 4.58073236667486 0.068776608222662 0.323851019300884 GO:0005542 folic acid binding 2/626 13/18639 0.153846153846154 4.58073236667486 0.068776608222662 0.323851019300884 GO:0008035 high-density lipoprotein particle binding 2/626 13/18639 0.153846153846154 4.58073236667486 0.068776608222662 0.323851019300884 GO:0031432 titin binding 2/626 13/18639 0.153846153846154 4.58073236667486 0.068776608222662 0.323851019300884 GO:0039706 co-receptor binding 2/626 13/18639 0.153846153846154 4.58073236667486 0.068776608222662 0.323851019300884 GO:0140666 annealing activity 2/626 13/18639 0.153846153846154 4.58073236667486 0.068776608222662 0.323851019300884 GO:0015616 DNA translocase activity 9/626 152/18639 0.0592105263157895 1.76297923322684 0.0709213657910402 0.330739061621678 GO:0140674 ATP-dependent histone chaperone activity 9/626 152/18639 0.0592105263157895 1.76297923322684 0.0709213657910402 0.330739061621678 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/626 67/18639 0.0746268656716418 2.22199704353631 0.0743050032676529 0.344860541481451 GO:0004386 helicase activity 9/626 155/18639 0.0580645161290323 1.72885705451922 0.0780036528340624 0.350921164015357 GO:0016769 transferase activity, transferring nitrogenous groups 3/626 30/18639 0.1 2.97747603833866 0.0783608749915663 0.350921164015357 GO:0005161 platelet-derived growth factor receptor binding 2/626 14/18639 0.142857142857143 4.25353719762665 0.0785050439085901 0.350921164015357 GO:0005545 1-phosphatidylinositol binding 2/626 14/18639 0.142857142857143 4.25353719762665 0.0785050439085901 0.350921164015357 GO:0008191 metalloendopeptidase inhibitor activity 2/626 14/18639 0.142857142857143 4.25353719762665 0.0785050439085901 0.350921164015357 GO:0034236 protein kinase A catalytic subunit binding 2/626 14/18639 0.142857142857143 4.25353719762665 0.0785050439085901 0.350921164015357 GO:0042043 neurexin family protein binding 2/626 14/18639 0.142857142857143 4.25353719762665 0.0785050439085901 0.350921164015357 GO:0043176 amine binding 2/626 14/18639 0.142857142857143 4.25353719762665 0.0785050439085901 0.350921164015357 GO:0019210 kinase inhibitor activity 6/626 90/18639 0.0666666666666667 1.98498402555911 0.0822632631394932 0.366033785528938 GO:0140658 ATP-dependent chromatin remodeler activity 9/626 158/18639 0.0569620253164557 1.69603065474987 0.0855022815379944 0.378708735579245 GO:0019787 ubiquitin-like protein transferase activity 22/626 479/18639 0.0459290187891441 1.36752552909082 0.0865660805805009 0.381677718923118 GO:0004559 alpha-mannosidase activity 2/626 15/18639 0.133333333333333 3.96996805111821 0.0886308136182585 0.383803076829066 GO:0005041 low-density lipoprotein particle receptor activity 2/626 15/18639 0.133333333333333 3.96996805111821 0.0886308136182585 0.383803076829066 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/626 15/18639 0.133333333333333 3.96996805111821 0.0886308136182585 0.383803076829066 GO:0042809 nuclear vitamin D receptor binding 2/626 15/18639 0.133333333333333 3.96996805111821 0.0886308136182585 0.383803076829066 GO:0003689 DNA clamp loader activity 9/626 160/18639 0.05625 1.6748302715655 0.0907326322211991 0.389268623768385 GO:0031369 translation initiation factor binding 3/626 32/18639 0.09375 2.79138378594249 0.0912236320814135 0.389268623768385 GO:0005272 sodium channel activity 4/626 51/18639 0.0784313725490196 2.33527532418718 0.0914981919785482 0.389268623768385 GO:0016830 carbon-carbon lyase activity 4/626 51/18639 0.0784313725490196 2.33527532418718 0.0914981919785482 0.389268623768385 GO:0005178 integrin binding 9/626 161/18639 0.0559006211180124 1.6644275990713 0.0934170381386141 0.395696624429938 GO:0005518 collagen binding 5/626 72/18639 0.0694444444444444 2.06769169329073 0.0943123615755076 0.397752133601054 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/626 33/18639 0.0909090909090909 2.70679639848969 0.097962270092062 0.400595263535168 GO:0003688 DNA replication origin binding 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0015923 mannosidase activity 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0022858 alanine transmembrane transporter activity 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0043023 ribosomal large subunit binding 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0055102 lipase inhibitor activity 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0070411 I-SMAD binding 2/626 16/18639 0.125 3.72184504792332 0.0991163538643714 0.400595263535168 GO:0140713 histone chaperone activity 9/626 164/18639 0.0548780487804878 1.63398075274682 0.101746023377134 0.406765149004123 GO:0030695 GTPase regulator activity 22/626 489/18639 0.0449897750511247 1.3395597718497 0.101759479655369 0.406765149004123 GO:0004864 protein phosphatase inhibitor activity 4/626 53/18639 0.0754716981132075 2.24715172704804 0.101900960008249 0.406765149004123 GO:0140597 protein carrier chaperone 10/626 188/18639 0.0531914893617021 1.58376385018014 0.102488801852594 0.40743499097138 GO:0060589 nucleoside-triphosphatase regulator activity 22/626 490/18639 0.0448979591836735 1.33682597639695 0.103366937008186 0.409248689379349 GO:0030332 cyclin binding 3/626 34/18639 0.0882352941176471 2.62718473971058 0.104895466463682 0.413612205161672 GO:0016018 cyclosporin A binding 2/626 17/18639 0.117647058823529 3.50291298628077 0.109926169047162 0.428226441669667 GO:0036041 long-chain fatty acid binding 2/626 17/18639 0.117647058823529 3.50291298628077 0.109926169047162 0.428226441669667 GO:0070402 NADPH binding 2/626 17/18639 0.117647058823529 3.50291298628077 0.109926169047162 0.428226441669667 GO:0010485 histone H4 acetyltransferase activity 3/626 35/18639 0.0857142857142857 2.55212231857599 0.112015315064951 0.434619422452012 GO:0016755 aminoacyltransferase activity 22/626 496/18639 0.0443548387096774 1.3206546944244 0.113349655980051 0.438044487253585 GO:0046982 protein heterodimerization activity 17/626 369/18639 0.046070460704607 1.3717369282319 0.118013509291202 0.451522820108258 GO:0019212 phosphatase inhibitor activity 4/626 56/18639 0.0714285714285714 2.12676859881333 0.118466265685226 0.451522820108258 GO:0055106 ubiquitin-protein transferase regulator activity 3/626 36/18639 0.0833333333333333 2.48123003194888 0.119313794244209 0.451522820108258 GO:0003746 translation elongation factor activity 2/626 18/18639 0.111111111111111 3.30830670926518 0.121026735286749 0.451522820108258 GO:0015172 acidic amino acid transmembrane transporter activity 2/626 18/18639 0.111111111111111 3.30830670926518 0.121026735286749 0.451522820108258 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/626 18/18639 0.111111111111111 3.30830670926518 0.121026735286749 0.451522820108258 GO:0030228 lipoprotein particle receptor activity 2/626 18/18639 0.111111111111111 3.30830670926518 0.121026735286749 0.451522820108258 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/626 18/18639 0.111111111111111 3.30830670926518 0.121026735286749 0.451522820108258 GO:0050811 GABA receptor binding 2/626 18/18639 0.111111111111111 3.30830670926518 0.121026735286749 0.451522820108258 GO:0004842 ubiquitin-protein transferase activity 20/626 449/18639 0.044543429844098 1.32626995026221 0.122727804623734 0.45611482944453 GO:0015245 fatty acid transmembrane transporter activity 2/626 19/18639 0.105263157894737 3.13418530351438 0.13238640836632 0.490132885936375 GO:0004519 endonuclease activity 7/626 127/18639 0.0551181102362205 1.64112852506855 0.135892404647051 0.500101615416092 GO:0004879 nuclear receptor activity 4/626 59/18639 0.0677966101694915 2.01862782260248 0.136110130381287 0.500101615416092 GO:0098531 ligand-modulated transcription factor activity 4/626 60/18639 0.0666666666666667 1.98498402555911 0.142215481760197 0.520562329461852 GO:0010851 cyclase regulator activity 2/626 20/18639 0.1 2.97747603833866 0.143975335619151 0.521104759517077 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/626 20/18639 0.1 2.97747603833866 0.143975335619151 0.521104759517077 GO:0030742 GTP-dependent protein binding 2/626 20/18639 0.1 2.97747603833866 0.143975335619151 0.521104759517077 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/626 40/18639 0.075 2.23310702875399 0.150131201176719 0.537369982071651 GO:0061791 GTPase motor activity 3/626 40/18639 0.075 2.23310702875399 0.150131201176719 0.537369982071651 GO:1990606 membrane scission GTPase motor activity 3/626 40/18639 0.075 2.23310702875399 0.150131201176719 0.537369982071651 GO:0005085 guanyl-nucleotide exchange factor activity 11/626 230/18639 0.0478260869565217 1.42401027920545 0.152827991078314 0.545011585830751 GO:0015179 L-amino acid transmembrane transporter activity 4/626 62/18639 0.0645161290322581 1.92095228279913 0.154741103777042 0.547436269750373 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/626 21/18639 0.0952380952380952 2.83569146508444 0.155765371599075 0.547436269750373 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/626 21/18639 0.0952380952380952 2.83569146508444 0.155765371599075 0.547436269750373 GO:0051010 microtubule plus-end binding 2/626 21/18639 0.0952380952380952 2.83569146508444 0.155765371599075 0.547436269750373 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/626 41/18639 0.0731707317073171 2.17864100366243 0.158200493088374 0.553987286266147 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/626 86/18639 0.0581395348837209 1.73109071996434 0.16280358009557 0.555283609074545 GO:0004402 histone acetyltransferase activity 3/626 42/18639 0.0714285714285714 2.12676859881333 0.1663994259852 0.555283609074545 GO:0008093 cytoskeletal anchor activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0032931 histone H3K56 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0043992 histone H3K9 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0043993 histone H3K18 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0043994 histone H3K23 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0043999 histone H2AK5 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0044012 histone H2AK9 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0044014 histone H2BK5 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0044015 histone H2BK12 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0044016 histone H3K4 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0044017 histone H3K27 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0044018 histone H3K36 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0046972 histone H4K16 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0140908 histone H3K122 acetyltransferase activity 2/626 22/18639 0.0909090909090909 2.70679639848969 0.167729997380249 0.555283609074545 GO:0008094 ATP-dependent activity, acting on DNA 10/626 210/18639 0.0476190476190476 1.41784573254222 0.170301075457676 0.56187769793859 GO:1901981 phosphatidylinositol phosphate binding 9/626 185/18639 0.0486486486486487 1.44850185648908 0.171148260322669 0.562758686484708 GO:0003730 mRNA 3'-UTR binding 12/626 262/18639 0.0458015267175573 1.36372948320855 0.172996710014843 0.566914894305397 GO:0120013 lipid transfer activity 4/626 65/18639 0.0615384615384615 1.83229294666994 0.174261854616239 0.569138043696134 GO:0005158 insulin receptor binding 2/626 23/18639 0.0869565217391304 2.58910959855535 0.17984424333818 0.577645417344484 GO:0031681 G-protein beta-subunit binding 2/626 23/18639 0.0869565217391304 2.58910959855535 0.17984424333818 0.577645417344484 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/626 23/18639 0.0869565217391304 2.58910959855535 0.17984424333818 0.577645417344484 GO:0070577 lysine-acetylated histone binding 2/626 23/18639 0.0869565217391304 2.58910959855535 0.17984424333818 0.577645417344484 GO:0099186 structural constituent of postsynapse 2/626 23/18639 0.0869565217391304 2.58910959855535 0.17984424333818 0.577645417344484 GO:0046943 carboxylic acid transmembrane transporter activity 9/626 188/18639 0.0478723404255319 1.42538746516212 0.182532186040972 0.584343961913344 GO:0005342 organic acid transmembrane transporter activity 9/626 189/18639 0.0476190476190476 1.41784573254222 0.186400523024376 0.594764826755409 GO:0015081 sodium ion transmembrane transporter activity 8/626 164/18639 0.0487804878048781 1.45242733577496 0.187478705953069 0.595278200676284 GO:0046915 transition metal ion transmembrane transporter activity 3/626 45/18639 0.0666666666666667 1.98498402555911 0.191693521746714 0.595278200676284 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/626 24/18639 0.0833333333333333 2.48123003194888 0.19208461526977 0.595278200676284 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/626 24/18639 0.0833333333333333 2.48123003194888 0.19208461526977 0.595278200676284 GO:0015295 solute:proton symporter activity 2/626 24/18639 0.0833333333333333 2.48123003194888 0.19208461526977 0.595278200676284 GO:0030552 cAMP binding 2/626 24/18639 0.0833333333333333 2.48123003194888 0.19208461526977 0.595278200676284 GO:0035035 histone acetyltransferase binding 2/626 24/18639 0.0833333333333333 2.48123003194888 0.19208461526977 0.595278200676284 GO:0043998 histone H2A acetyltransferase activity 2/626 24/18639 0.0833333333333333 2.48123003194888 0.19208461526977 0.595278200676284 GO:0140033 acetylation-dependent protein binding 2/626 24/18639 0.0833333333333333 2.48123003194888 0.19208461526977 0.595278200676284 GO:0015294 solute:monoatomic cation symporter activity 6/626 116/18639 0.0517241379310345 1.54007381293379 0.195371376521053 0.602341638375155 GO:0008514 organic anion transmembrane transporter activity 12/626 269/18639 0.0446096654275093 1.32824209888713 0.195605789781623 0.602341638375155 GO:0004180 carboxypeptidase activity 3/626 46/18639 0.0652173913043478 1.94183219891652 0.200330885345964 0.613919978341458 GO:0008080 N-acetyltransferase activity 4/626 69/18639 0.0579710144927536 1.72607306570357 0.201498375150833 0.613919978341458 GO:0005096 GTPase activator activity 12/626 271/18639 0.044280442804428 1.3184395741721 0.202302263955829 0.613919978341458 GO:0001848 complement binding 2/626 25/18639 0.08 2.38198083067093 0.204429023715764 0.613919978341458 GO:0003707 nuclear steroid receptor activity 2/626 25/18639 0.08 2.38198083067093 0.204429023715764 0.613919978341458 GO:0017025 TBP-class protein binding 2/626 25/18639 0.08 2.38198083067093 0.204429023715764 0.613919978341458 GO:0047617 fatty acyl-CoA hydrolase activity 2/626 25/18639 0.08 2.38198083067093 0.204429023715764 0.613919978341458 GO:0120020 cholesterol transfer activity 2/626 25/18639 0.08 2.38198083067093 0.204429023715764 0.613919978341458 GO:0005504 fatty acid binding 3/626 47/18639 0.0638297872340425 1.90051662021616 0.209058287029897 0.620142319324159 GO:0043495 protein-membrane adaptor activity 3/626 47/18639 0.0638297872340425 1.90051662021616 0.209058287029897 0.620142319324159 GO:0061733 protein-lysine-acetyltransferase activity 3/626 47/18639 0.0638297872340425 1.90051662021616 0.209058287029897 0.620142319324159 GO:0140359 ABC-type transporter activity 3/626 47/18639 0.0638297872340425 1.90051662021616 0.209058287029897 0.620142319324159 GO:0042393 histone binding 11/626 247/18639 0.0445344129554656 1.32600147456377 0.210133284257516 0.621430749176192 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/626 26/18639 0.0769230769230769 2.29036618333743 0.216856716354337 0.625242854777858 GO:0008143 poly(A) binding 2/626 26/18639 0.0769230769230769 2.29036618333743 0.216856716354337 0.625242854777858 GO:0008198 ferrous iron binding 2/626 26/18639 0.0769230769230769 2.29036618333743 0.216856716354337 0.625242854777858 GO:0015216 purine nucleotide transmembrane transporter activity 2/626 26/18639 0.0769230769230769 2.29036618333743 0.216856716354337 0.625242854777858 GO:0016289 acyl-CoA hydrolase activity 2/626 26/18639 0.0769230769230769 2.29036618333743 0.216856716354337 0.625242854777858 GO:0043548 phosphatidylinositol 3-kinase binding 2/626 26/18639 0.0769230769230769 2.29036618333743 0.216856716354337 0.625242854777858 GO:0070006 metalloaminopeptidase activity 2/626 26/18639 0.0769230769230769 2.29036618333743 0.216856716354337 0.625242854777858 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/626 48/18639 0.0625 1.86092252396166 0.217868128778264 0.625242854777858 GO:0032266 phosphatidylinositol-3-phosphate binding 3/626 48/18639 0.0625 1.86092252396166 0.217868128778264 0.625242854777858 GO:0038187 pattern recognition receptor activity 3/626 48/18639 0.0625 1.86092252396166 0.217868128778264 0.625242854777858 GO:0004364 glutathione transferase activity 2/626 27/18639 0.0740740740740741 2.20553780617678 0.229348213339794 0.648594072710205 GO:0005044 scavenger receptor activity 2/626 27/18639 0.0740740740740741 2.20553780617678 0.229348213339794 0.648594072710205 GO:0005385 zinc ion transmembrane transporter activity 2/626 27/18639 0.0740740740740741 2.20553780617678 0.229348213339794 0.648594072710205 GO:0015252 proton channel activity 2/626 27/18639 0.0740740740740741 2.20553780617678 0.229348213339794 0.648594072710205 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/626 27/18639 0.0740740740740741 2.20553780617678 0.229348213339794 0.648594072710205 GO:0061134 peptidase regulator activity 10/626 226/18639 0.0442477876106195 1.31746727360118 0.230145071747211 0.648955580217426 GO:0016829 lyase activity 9/626 200/18639 0.045 1.3398642172524 0.231185658370231 0.650000256867027 GO:0030246 carbohydrate binding 12/626 280/18639 0.0428571428571429 1.276061159288 0.233636744979062 0.654993186791012 GO:0003678 DNA helicase activity 4/626 74/18639 0.0540540540540541 1.60944650721009 0.237142008220207 0.662904172834586 GO:0140097 catalytic activity, acting on DNA 14/626 336/18639 0.0416666666666667 1.24061501597444 0.241284819775966 0.672288504588318 GO:0036408 histone H3K14 acetyltransferase activity 2/626 28/18639 0.0714285714285714 2.12676859881333 0.241885245465281 0.672288504588318 GO:0016597 amino acid binding 3/626 51/18639 0.0588235294117647 1.75145649314039 0.24471836815301 0.678219477452629 GO:0043130 ubiquitin binding 5/626 100/18639 0.05 1.48873801916933 0.245746692344238 0.679129035823107 GO:0035091 phosphatidylinositol binding 12/626 284/18639 0.0422535211267606 1.25808846690366 0.248144735441322 0.681244230639978 GO:0010484 histone H3 acetyltransferase activity 2/626 29/18639 0.0689655172413793 2.05343175057838 0.254450695033243 0.681244230639978 GO:0051861 glycolipid binding 2/626 29/18639 0.0689655172413793 2.05343175057838 0.254450695033243 0.681244230639978 GO:0099604 ligand-gated calcium channel activity 2/626 29/18639 0.0689655172413793 2.05343175057838 0.254450695033243 0.681244230639978 GO:0015171 amino acid transmembrane transporter activity 5/626 102/18639 0.0490196078431373 1.45954707761699 0.258425153559706 0.681244230639978 GO:0031490 chromatin DNA binding 6/626 128/18639 0.046875 1.39569189297125 0.260709526607188 0.681244230639978 GO:0051020 GTPase binding 13/626 315/18639 0.0412698412698413 1.22879963486992 0.26240348600362 0.681244230639978 GO:0005246 calcium channel regulator activity 3/626 53/18639 0.0566037735849057 1.68536379528603 0.262897814655084 0.681244230639978 GO:0005544 calcium-dependent phospholipid binding 3/626 53/18639 0.0566037735849057 1.68536379528603 0.262897814655084 0.681244230639978 GO:0034212 protein N-acetyltransferase activity 3/626 53/18639 0.0566037735849057 1.68536379528603 0.262897814655084 0.681244230639978 GO:0140296 general transcription initiation factor binding 3/626 53/18639 0.0566037735849057 1.68536379528603 0.262897814655084 0.681244230639978 GO:0001965 G-protein alpha-subunit binding 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0008187 poly-pyrimidine tract binding 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0015215 nucleotide transmembrane transporter activity 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0043995 histone H4K5 acetyltransferase activity 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0043996 histone H4K8 acetyltransferase activity 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0043997 histone H4K12 acetyltransferase activity 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0048019 receptor antagonist activity 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0070566 adenylyltransferase activity 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0098918 structural constituent of synapse 2/626 30/18639 0.0666666666666667 1.98498402555911 0.267028539321934 0.681244230639978 GO:0004518 nuclease activity 9/626 209/18639 0.0430622009569378 1.28216671507406 0.270455728289669 0.681244230639978 GO:0051015 actin filament binding 9/626 209/18639 0.0430622009569378 1.28216671507406 0.270455728289669 0.681244230639978 GO:0003925 G protein activity 3/626 54/18639 0.0555555555555556 1.65415335463259 0.272050771339815 0.681244230639978 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6/626 130/18639 0.0461538461538462 1.37421971000246 0.27213385086509 0.681244230639978 GO:0046332 SMAD binding 4/626 79/18639 0.0506329113924051 1.50758280422211 0.27411627207216 0.681244230639978 GO:0070273 phosphatidylinositol-4-phosphate binding 2/626 31/18639 0.0645161290322581 1.92095228279913 0.279603796540749 0.681244230639978 GO:0072349 modified amino acid transmembrane transporter activity 2/626 31/18639 0.0645161290322581 1.92095228279913 0.279603796540749 0.681244230639978 GO:0015101 organic cation transmembrane transporter activity 4/626 81/18639 0.0493827160493827 1.47035853745119 0.289174414529596 0.681244230639978 GO:0030971 receptor tyrosine kinase binding 4/626 81/18639 0.0493827160493827 1.47035853745119 0.289174414529596 0.681244230639978 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0003796 lysozyme activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0005345 purine nucleobase transmembrane transporter activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0005381 iron ion transmembrane transporter activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0005522 profilin binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0008190 eukaryotic initiation factor 4E binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0008239 dipeptidyl-peptidase activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0008519 ammonium channel activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0015203 polyamine transmembrane transporter activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0031996 thioesterase binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0032395 MHC class II receptor activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0047429 nucleoside triphosphate diphosphatase activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0050815 phosphoserine residue binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0051378 serotonin binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0070513 death domain binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:1905394 retromer complex binding 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/626 10/18639 0.1 2.97747603833866 0.289444581530722 0.681244230639978 GO:0030170 pyridoxal phosphate binding 3/626 56/18639 0.0535714285714286 1.59507644911 0.290450587497892 0.681244230639978 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/626 32/18639 0.0625 1.86092252396166 0.292162474171372 0.681244230639978 GO:0042910 xenobiotic transmembrane transporter activity 2/626 32/18639 0.0625 1.86092252396166 0.292162474171372 0.681244230639978 GO:0070717 poly-purine tract binding 2/626 32/18639 0.0625 1.86092252396166 0.292162474171372 0.681244230639978 GO:0120015 sterol transfer activity 2/626 32/18639 0.0625 1.86092252396166 0.292162474171372 0.681244230639978 GO:0140142 nucleocytoplasmic carrier activity 2/626 32/18639 0.0625 1.86092252396166 0.292162474171372 0.681244230639978 GO:0016504 peptidase activator activity 3/626 57/18639 0.0526315789473684 1.56709265175719 0.299684948711413 0.684509219285957 GO:0070279 vitamin B6 binding 3/626 57/18639 0.0526315789473684 1.56709265175719 0.299684948711413 0.684509219285957 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 4/626 83/18639 0.0481927710843374 1.43492821124755 0.304342937737227 0.684509219285957 GO:0071889 14-3-3 protein binding 2/626 33/18639 0.0606060606060606 1.80453093232646 0.304691519595843 0.684509219285957 GO:0051117 ATPase binding 4/626 84/18639 0.0476190476190476 1.41784573254222 0.311959935892487 0.684509219285957 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0015173 aromatic amino acid transmembrane transporter activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0015205 nucleobase transmembrane transporter activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0015217 ADP transmembrane transporter activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0034056 estrogen response element binding 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0034713 type I transforming growth factor beta receptor binding 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0042608 T cell receptor binding 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0045294 alpha-catenin binding 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0047676 arachidonate-CoA ligase activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0048407 platelet-derived growth factor binding 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0050786 RAGE receptor binding 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0070697 activin receptor binding 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0097493 structural molecule activity conferring elasticity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0140537 transcription regulator activator activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0180030 inositol phosphate kinase activity 1/626 11/18639 0.0909090909090909 2.70679639848969 0.313321745735015 0.684509219285957 GO:0140857 histone H3T45 kinase activity 10/626 246/18639 0.040650406504065 1.2103561131458 0.314070536582018 0.684603192100129 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/626 34/18639 0.0588235294117647 1.75145649314039 0.317178772916603 0.686748682431038 GO:0016831 carboxy-lyase activity 2/626 34/18639 0.0588235294117647 1.75145649314039 0.317178772916603 0.686748682431038 GO:0090482 vitamin transmembrane transporter activity 2/626 34/18639 0.0588235294117647 1.75145649314039 0.317178772916603 0.686748682431038 GO:0035403 histone H3T6 kinase activity 10/626 247/18639 0.0404858299595142 1.20545588596707 0.318456074654782 0.687978602260887 GO:0003779 actin binding 17/626 443/18639 0.0383747178329571 1.14259802825637 0.321043034010502 0.691325970554634 GO:0070851 growth factor receptor binding 6/626 139/18639 0.0431654676258993 1.28524145539798 0.324820262646769 0.691325970554634 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/626 60/18639 0.05 1.48873801916933 0.327454638152996 0.691325970554634 GO:0005154 epidermal growth factor receptor binding 2/626 35/18639 0.0571428571428571 1.70141487905066 0.329612921877309 0.691325970554634 GO:0016229 steroid dehydrogenase activity 2/626 35/18639 0.0571428571428571 1.70141487905066 0.329612921877309 0.691325970554634 GO:0008081 phosphoric diester hydrolase activity 4/626 87/18639 0.0459770114942529 1.36895450038559 0.334901665310902 0.691325970554634 GO:0003720 telomerase activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0004300 enoyl-CoA hydratase activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0005078 MAP-kinase scaffold activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0008504 monoamine transmembrane transporter activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0015166 polyol transmembrane transporter activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0015269 calcium-activated potassium channel activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0016208 AMP binding 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0016273 arginine N-methyltransferase activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0016274 protein-arginine N-methyltransferase activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0031543 peptidyl-proline dioxygenase activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0034452 dynactin binding 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0035197 siRNA binding 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:1990817 poly(A) RNA polymerase activity 1/626 12/18639 0.0833333333333333 2.48123003194888 0.336397791857513 0.691325970554634 GO:0030414 peptidase inhibitor activity 7/626 169/18639 0.0414201183431953 1.23327409872015 0.340632599778455 0.695438060865822 GO:0004033 aldo-keto reductase (NADPH) activity 2/626 36/18639 0.0555555555555556 1.65415335463259 0.341983458796904 0.695438060865822 GO:0005484 SNAP receptor activity 2/626 36/18639 0.0555555555555556 1.65415335463259 0.341983458796904 0.695438060865822 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/626 36/18639 0.0555555555555556 1.65415335463259 0.341983458796904 0.695438060865822 GO:0045505 dynein intermediate chain binding 2/626 36/18639 0.0555555555555556 1.65415335463259 0.341983458796904 0.695438060865822 GO:0022829 wide pore channel activity 2/626 37/18639 0.0540540540540541 1.60944650721009 0.354280639432877 0.698671828204025 GO:0030551 cyclic nucleotide binding 2/626 37/18639 0.0540540540540541 1.60944650721009 0.354280639432877 0.698671828204025 GO:0043394 proteoglycan binding 2/626 37/18639 0.0540540540540541 1.60944650721009 0.354280639432877 0.698671828204025 GO:0019955 cytokine binding 6/626 144/18639 0.0416666666666667 1.24061501597444 0.354695023660765 0.698671828204025 GO:1990782 protein tyrosine kinase binding 5/626 117/18639 0.0427350427350427 1.27242565740968 0.357070841079545 0.698671828204025 GO:0003964 RNA-directed DNA polymerase activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0004535 poly(A)-specific ribonuclease activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0004993 G protein-coupled serotonin receptor activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0017154 semaphorin receptor activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0019104 DNA N-glycosylase activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0019855 calcium channel inhibitor activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0035325 Toll-like receptor binding 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0035673 oligopeptide transmembrane transporter activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0043560 insulin receptor substrate binding 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0097157 pre-mRNA intronic binding 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0140852 histone ubiquitin ligase activity 1/626 13/18639 0.0769230769230769 2.29036618333743 0.358699557160417 0.698671828204025 GO:0042887 amide transmembrane transporter activity 2/626 38/18639 0.0526315789473684 1.56709265175719 0.366495443693054 0.705362487559172 GO:0043531 ADP binding 2/626 38/18639 0.0526315789473684 1.56709265175719 0.366495443693054 0.705362487559172 GO:0015293 symporter activity 6/626 146/18639 0.0410958904109589 1.22362028972822 0.366707751058379 0.705362487559172 GO:0003823 antigen binding 7/626 174/18639 0.0402298850574713 1.19783518783739 0.368043612663672 0.705362487559172 GO:0015085 calcium ion transmembrane transporter activity 6/626 147/18639 0.0408163265306122 1.21529634217904 0.372721576734782 0.705362487559172 GO:0160215 deacylase activity 3/626 65/18639 0.0461538461538462 1.37421971000246 0.373633602937796 0.705362487559172 GO:0032182 ubiquitin-like protein binding 5/626 120/18639 0.0416666666666667 1.24061501597444 0.377154670486479 0.705362487559172 GO:0000217 DNA secondary structure binding 2/626 39/18639 0.0512820512820513 1.52691078889162 0.37861953811843 0.705362487559172 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/626 39/18639 0.0512820512820513 1.52691078889162 0.37861953811843 0.705362487559172 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/626 39/18639 0.0512820512820513 1.52691078889162 0.37861953811843 0.705362487559172 GO:0005313 L-glutamate transmembrane transporter activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0005344 oxygen carrier activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0005347 ATP transmembrane transporter activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0008195 phosphatidate phosphatase activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0008474 palmitoyl-(protein) hydrolase activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0008559 ABC-type xenobiotic transporter activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0015386 potassium:proton antiporter activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0016530 metallochaperone activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0019992 diacylglycerol binding 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0061665 SUMO ligase activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0061783 peptidoglycan muralytic activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0098599 palmitoyl hydrolase activity 1/626 14/18639 0.0714285714285714 2.12676859881333 0.380252981256712 0.705362487559172 GO:0004674 protein serine/threonine kinase activity 16/626 433/18639 0.0369515011547344 1.10022209268865 0.383741849903705 0.705362487559172 GO:0004540 RNA nuclease activity 5/626 121/18639 0.0413223140495868 1.2303619993135 0.383849127315498 0.705362487559172 GO:0016410 N-acyltransferase activity 4/626 94/18639 0.0425531914893617 1.26701108014411 0.388557430625526 0.705362487559172 GO:0042562 hormone binding 4/626 94/18639 0.0425531914893617 1.26701108014411 0.388557430625526 0.705362487559172 GO:0005319 lipid transporter activity 7/626 178/18639 0.0393258426966292 1.17091754316689 0.390077895102362 0.705362487559172 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 5/626 122/18639 0.040983606557377 1.22027706489289 0.390540281110025 0.705362487559172 GO:0004177 aminopeptidase activity 2/626 40/18639 0.05 1.48873801916933 0.39064524006273 0.705362487559172 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/626 40/18639 0.05 1.48873801916933 0.39064524006273 0.705362487559172 GO:0032451 demethylase activity 2/626 40/18639 0.05 1.48873801916933 0.39064524006273 0.705362487559172 GO:0071949 FAD binding 2/626 40/18639 0.05 1.48873801916933 0.39064524006273 0.705362487559172 GO:0019842 vitamin binding 6/626 150/18639 0.04 1.19099041533546 0.390775444206513 0.705362487559172 GO:0050840 extracellular matrix binding 3/626 67/18639 0.0447761194029851 1.33319822612179 0.391953849317584 0.705362487559172 GO:0005548 phospholipid transporter activity 3/626 68/18639 0.0441176470588235 1.31359236985529 0.401063818600505 0.705362487559172 GO:0000774 adenyl-nucleotide exchange factor activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0004129 cytochrome-c oxidase activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0004467 long-chain fatty acid-CoA ligase activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0015929 hexosaminidase activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0017081 chloride channel regulator activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0030553 cGMP binding 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0033130 acetylcholine receptor binding 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0048531 beta-1,3-galactosyltransferase activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0141050 histone H3K deacetylase activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0141051 histone H4K deacetylase activity 1/626 15/18639 0.0666666666666667 1.98498402555911 0.401083136088029 0.705362487559172 GO:0001530 lipopolysaccharide binding 2/626 41/18639 0.0487804878048781 1.45242733577496 0.402565483497313 0.705362487559172 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/626 41/18639 0.0487804878048781 1.45242733577496 0.402565483497313 0.705362487559172 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/626 41/18639 0.0487804878048781 1.45242733577496 0.402565483497313 0.705362487559172 GO:0016407 acetyltransferase activity 4/626 96/18639 0.0416666666666667 1.24061501597444 0.403814192645335 0.705362487559172 GO:0003774 cytoskeletal motor activity 6/626 153/18639 0.0392156862745098 1.16763766209359 0.408818215702312 0.705362487559172 GO:0002039 p53 binding 3/626 69/18639 0.0434782608695652 1.29455479927768 0.410134975120945 0.705362487559172 GO:0001664 G protein-coupled receptor binding 11/626 297/18639 0.037037037037037 1.10276890308839 0.413689837382088 0.705362487559172 GO:0004520 DNA endonuclease activity 2/626 42/18639 0.0476190476190476 1.41784573254222 0.414373786372919 0.705362487559172 GO:0019894 kinesin binding 2/626 42/18639 0.0476190476190476 1.41784573254222 0.414373786372919 0.705362487559172 GO:0000062 fatty-acyl-CoA binding 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0005159 insulin-like growth factor receptor binding 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0005521 lamin binding 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0015378 sodium:chloride symporter activity 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0015385 sodium:proton antiporter activity 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0015562 efflux transmembrane transporter activity 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0016722 oxidoreductase activity, acting on metal ions 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0022841 potassium ion leak channel activity 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/626 16/18639 0.0625 1.86092252396166 0.42121425490294 0.705362487559172 GO:0140996 histone H3 kinase activity 13/626 357/18639 0.0364145658263305 1.08423497194405 0.422810044032737 0.705362487559172 GO:0061135 endopeptidase regulator activity 7/626 184/18639 0.0380434782608696 1.13273544936797 0.423138737392284 0.705362487559172 GO:0008375 acetylglucosaminyltransferase activity 2/626 43/18639 0.0465116279069767 1.38487257597147 0.426064219472536 0.705362487559172 GO:0140098 catalytic activity, acting on RNA 14/626 387/18639 0.0361757105943152 1.07712311464448 0.426628459983594 0.705362487559172 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 9/626 243/18639 0.037037037037037 1.10276890308839 0.430443596985704 0.705362487559172 GO:0035173 histone kinase activity 13/626 360/18639 0.0361111111111111 1.07519968051118 0.434645121292738 0.705362487559172 GO:0035591 signaling adaptor activity 5/626 129/18639 0.0387596899224806 1.15406047997622 0.437132102982255 0.705362487559172 GO:0016790 thiolester hydrolase activity 2/626 44/18639 0.0454545454545455 1.35339819924484 0.437631376692281 0.705362487559172 GO:0106310 protein serine kinase activity 13/626 361/18639 0.03601108033241 1.07222128804439 0.438589010834218 0.705362487559172 GO:0004676 3-phosphoinositide-dependent protein kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0004711 ribosomal protein S6 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0035175 histone H3S10 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0035979 histone H2AXS139 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0044022 histone H3S28 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0044023 histone H4S1 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0044024 histone H2AS1 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0044025 histone H2BS14 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0072354 histone H3T3 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0072371 histone H2AS121 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0072518 Rho-dependent protein serine/threonine kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0140823 histone H2BS36 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0140855 histone H3S57 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0140995 histone H2A kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0140997 histone H4 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0140998 histone H2B kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:1990244 histone H2AT120 kinase activity 9/626 245/18639 0.036734693877551 1.09376670796114 0.440022090916825 0.705362487559172 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0005092 GDP-dissociation inhibitor activity 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0008429 phosphatidylethanolamine binding 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0015278 intracellularly gated calcium channel activity 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0016805 dipeptidase activity 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0030548 acetylcholine receptor regulator activity 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0048038 quinone binding 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0070492 oligosaccharide binding 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:1901567 fatty acid derivative binding 1/626 17/18639 0.0588235294117647 1.75145649314039 0.440669760268926 0.705362487559172 GO:0004677 DNA-dependent protein kinase activity 9/626 246/18639 0.0365853658536585 1.08932050183122 0.444805061334602 0.705474542285129 GO:0004521 RNA endonuclease activity 3/626 73/18639 0.0410958904109589 1.22362028972822 0.445957671228827 0.705474542285129 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/626 45/18639 0.0444444444444444 1.32332268370607 0.449070346689749 0.705474542285129 GO:0008238 exopeptidase activity 4/626 102/18639 0.0392156862745098 1.16763766209359 0.449074431026218 0.705474542285129 GO:0035402 histone H3T11 kinase activity 9/626 247/18639 0.0364372469635627 1.08491029737036 0.449582964192242 0.705474542285129 GO:0005262 calcium channel activity 5/626 131/18639 0.0381679389312977 1.13644123600712 0.45031301915785 0.705474542285129 GO:0015079 potassium ion transmembrane transporter activity 6/626 160/18639 0.0375 1.116553514377 0.450671232853673 0.705474542285129 GO:0004679 AMP-activated protein kinase activity 9/626 248/18639 0.0362903225806452 1.08053565907451 0.454355146420315 0.705474542285129 GO:0048029 monosaccharide binding 3/626 74/18639 0.0405405405405405 1.20708488040756 0.45478086825736 0.705474542285129 GO:0004722 protein serine/threonine phosphatase activity 4/626 103/18639 0.0388349514563107 1.1563013741121 0.456518961688208 0.705474542285129 GO:0004866 endopeptidase inhibitor activity 6/626 161/18639 0.0372670807453416 1.10961839938087 0.456603451692798 0.705474542285129 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0004970 glutamate-gated receptor activity 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0008409 5'-3' exonuclease activity 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0008525 phosphatidylcholine transporter activity 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0015373 monoatomic anion:sodium symporter activity 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0016854 racemase and epimerase activity 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0031690 adrenergic receptor binding 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0034185 apolipoprotein binding 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0035615 clathrin adaptor activity 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0098641 cadherin binding involved in cell-cell adhesion 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0099602 neurotransmitter receptor regulator activity 1/626 18/18639 0.0555555555555556 1.65415335463259 0.45947229115023 0.705474542285129 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 17/626 484/18639 0.0351239669421488 1.04580769941647 0.460075191961434 0.705474542285129 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/626 46/18639 0.0434782608695652 1.29455479927768 0.460376685841739 0.705474542285129 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/626 46/18639 0.0434782608695652 1.29455479927768 0.460376685841739 0.705474542285129 GO:0030291 protein serine/threonine kinase inhibitor activity 2/626 46/18639 0.0434782608695652 1.29455479927768 0.460376685841739 0.705474542285129 GO:0019003 GDP binding 3/626 75/18639 0.04 1.19099041533546 0.463544842641925 0.708296727094259 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/626 47/18639 0.0425531914893617 1.26701108014411 0.471546392455599 0.708296727094259 GO:0003756 protein disulfide isomerase activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0005229 intracellularly calcium-gated chloride channel activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0008574 plus-end-directed microtubule motor activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0022821 solute:potassium antiporter activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0022840 leak channel activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0022842 narrow pore channel activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0042577 lipid phosphatase activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0050145 nucleoside monophosphate kinase activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0099589 serotonin receptor activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0120227 acyl-CoA binding 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0140036 ubiquitin-modified protein reader activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0141147 intracellularly calcium-gated channel activity 1/626 19/18639 0.0526315789473684 1.56709265175719 0.47764372908267 0.708296727094259 GO:0000149 SNARE binding 4/626 106/18639 0.0377358490566038 1.12357586352402 0.478640863687207 0.708296727094259 GO:0008013 beta-catenin binding 4/626 106/18639 0.0377358490566038 1.12357586352402 0.478640863687207 0.708296727094259 GO:0043138 3'-5' DNA helicase activity 2/626 48/18639 0.0416666666666667 1.24061501597444 0.4825758821807 0.708296727094259 GO:0099094 ligand-gated monoatomic cation channel activity 5/626 136/18639 0.0367647058823529 1.09466030821274 0.482880992248584 0.708296727094259 GO:0001216 DNA-binding transcription activator activity 17/626 491/18639 0.0346232179226069 1.0308980173474 0.484014157670259 0.708296727094259 GO:0004843 cysteine-type deubiquitinase activity 4/626 108/18639 0.037037037037037 1.10276890308839 0.49319341779362 0.708296727094259 GO:0005004 GPI-linked ephrin receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0005008 hepatocyte growth factor receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0005009 insulin receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0005011 macrophage colony-stimulating factor receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0005020 stem cell factor receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0008288 boss receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0016763 pentosyltransferase activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0036332 placental growth factor receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0038062 protein tyrosine kinase collagen receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0060175 brain-derived neurotrophic factor receptor activity 2/626 49/18639 0.0408163265306122 1.21529634217904 0.493461964568728 0.708296727094259 GO:0000339 RNA cap binding 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0001614 purinergic nucleotide receptor activity 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0015095 magnesium ion transmembrane transporter activity 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0016004 phospholipase activator activity 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0016408 C-acyltransferase activity 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0016502 nucleotide receptor activity 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0016505 peptidase activator activity involved in apoptotic process 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0031418 L-ascorbic acid binding 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0042288 MHC class I protein binding 1/626 20/18639 0.05 1.48873801916933 0.495205223475486 0.708296727094259 GO:0015370 solute:sodium symporter activity 3/626 79/18639 0.0379746835443038 1.13068710316658 0.497953931050189 0.708296727094259 GO:0016835 carbon-oxygen lyase activity 3/626 79/18639 0.0379746835443038 1.13068710316658 0.497953931050189 0.708296727094259 GO:0033293 monocarboxylic acid binding 3/626 79/18639 0.0379746835443038 1.13068710316658 0.497953931050189 0.708296727094259 GO:0015291 secondary active transmembrane transporter activity 10/626 287/18639 0.0348432055749129 1.03744809698211 0.498200621682954 0.708296727094259 GO:0140767 enzyme-substrate adaptor activity 5/626 139/18639 0.0359712230215827 1.07103454616498 0.502101452725349 0.708296727094259 GO:0005006 epidermal growth factor receptor activity 2/626 50/18639 0.04 1.19099041533546 0.504201820733536 0.708296727094259 GO:0005007 fibroblast growth factor receptor activity 2/626 50/18639 0.04 1.19099041533546 0.504201820733536 0.708296727094259 GO:0005017 platelet-derived growth factor receptor activity 2/626 50/18639 0.04 1.19099041533546 0.504201820733536 0.708296727094259 GO:0005019 platelet-derived growth factor beta-receptor activity 2/626 50/18639 0.04 1.19099041533546 0.504201820733536 0.708296727094259 GO:0015605 organophosphate ester transmembrane transporter activity 2/626 50/18639 0.04 1.19099041533546 0.504201820733536 0.708296727094259 GO:0005543 phospholipid binding 17/626 497/18639 0.03420523138833 1.01845256844582 0.504403058151552 0.708296727094259 GO:0004713 protein tyrosine kinase activity 5/626 140/18639 0.0357142857142857 1.06338429940666 0.50844701908654 0.708296727094259 GO:0001846 opsonin binding 1/626 21/18639 0.0476190476190476 1.41784573254222 0.512177216069307 0.708296727094259 GO:0005248 voltage-gated sodium channel activity 1/626 21/18639 0.0476190476190476 1.41784573254222 0.512177216069307 0.708296727094259 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/626 21/18639 0.0476190476190476 1.41784573254222 0.512177216069307 0.708296727094259 GO:0010314 phosphatidylinositol-5-phosphate binding 1/626 21/18639 0.0476190476190476 1.41784573254222 0.512177216069307 0.708296727094259 GO:0019200 carbohydrate kinase activity 1/626 21/18639 0.0476190476190476 1.41784573254222 0.512177216069307 0.708296727094259 GO:0140312 cargo adaptor activity 1/626 21/18639 0.0476190476190476 1.41784573254222 0.512177216069307 0.708296727094259 GO:0033192 calmodulin-dependent protein phosphatase activity 3/626 81/18639 0.037037037037037 1.10276890308839 0.514736287860031 0.708296727094259 GO:0140791 histone H2AXS140 phosphatase activity 3/626 81/18639 0.037037037037037 1.10276890308839 0.514736287860031 0.708296727094259 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/626 81/18639 0.037037037037037 1.10276890308839 0.514736287860031 0.708296727094259 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/626 81/18639 0.037037037037037 1.10276890308839 0.514736287860031 0.708296727094259 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/626 81/18639 0.037037037037037 1.10276890308839 0.514736287860031 0.708296727094259 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/626 81/18639 0.037037037037037 1.10276890308839 0.514736287860031 0.708296727094259 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/626 81/18639 0.037037037037037 1.10276890308839 0.514736287860031 0.708296727094259 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/626 81/18639 0.037037037037037 1.10276890308839 0.514736287860031 0.708296727094259 GO:0005010 insulin-like growth factor receptor activity 2/626 51/18639 0.0392156862745098 1.16763766209359 0.514792982063353 0.708296727094259 GO:0005021 vascular endothelial growth factor receptor activity 2/626 51/18639 0.0392156862745098 1.16763766209359 0.514792982063353 0.708296727094259 GO:0005030 neurotrophin receptor activity 2/626 51/18639 0.0392156862745098 1.16763766209359 0.514792982063353 0.708296727094259 GO:0020037 heme binding 5/626 142/18639 0.0352112676056338 1.04840705575305 0.521039055292702 0.715093557379304 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/626 82/18639 0.0365853658536585 1.08932050183122 0.523014376394331 0.715093557379304 GO:0033549 MAP kinase phosphatase activity 3/626 82/18639 0.0365853658536585 1.08932050183122 0.523014376394331 0.715093557379304 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/626 52/18639 0.0384615384615385 1.14518309166871 0.525233309940016 0.715093557379304 GO:0030159 signaling receptor complex adaptor activity 2/626 52/18639 0.0384615384615385 1.14518309166871 0.525233309940016 0.715093557379304 GO:0141003 histone H2AX kinase activity 12/626 354/18639 0.0338983050847458 1.00931391130124 0.528401298999569 0.715093557379304 GO:0004407 histone deacetylase activity 1/626 22/18639 0.0454545454545455 1.35339819924484 0.52857946457831 0.715093557379304 GO:0015377 chloride:monoatomic cation symporter activity 1/626 22/18639 0.0454545454545455 1.35339819924484 0.52857946457831 0.715093557379304 GO:0033558 protein lysine deacetylase activity 1/626 22/18639 0.0454545454545455 1.35339819924484 0.52857946457831 0.715093557379304 GO:0061133 endopeptidase activator activity 1/626 22/18639 0.0454545454545455 1.35339819924484 0.52857946457831 0.715093557379304 GO:0070034 telomerase RNA binding 1/626 22/18639 0.0454545454545455 1.35339819924484 0.52857946457831 0.715093557379304 GO:0140035 ubiquitin-like protein reader activity 1/626 22/18639 0.0454545454545455 1.35339819924484 0.52857946457831 0.715093557379304 GO:0005003 ephrin receptor activity 2/626 53/18639 0.0377358490566038 1.12357586352402 0.535520976421778 0.719467239791032 GO:0005005 transmembrane-ephrin receptor activity 2/626 53/18639 0.0377358490566038 1.12357586352402 0.535520976421778 0.719467239791032 GO:0038064 collagen receptor activity 2/626 53/18639 0.0377358490566038 1.12357586352402 0.535520976421778 0.719467239791032 GO:0051018 protein kinase A binding 2/626 53/18639 0.0377358490566038 1.12357586352402 0.535520976421778 0.719467239791032 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/626 53/18639 0.0377358490566038 1.12357586352402 0.535520976421778 0.719467239791032 GO:0004721 phosphoprotein phosphatase activity 6/626 175/18639 0.0342857142857143 1.0208489274304 0.537564237039595 0.721096474758266 GO:0017018 myosin phosphatase activity 3/626 84/18639 0.0357142857142857 1.06338429940666 0.539335096805139 0.721096474758266 GO:0001221 transcription coregulator binding 4/626 115/18639 0.0347826086956522 1.03564383942214 0.542685935833209 0.721096474758266 GO:0101005 deubiquitinase activity 4/626 115/18639 0.0347826086956522 1.03564383942214 0.542685935833209 0.721096474758266 GO:0000295 adenine nucleotide transmembrane transporter activity 1/626 23/18639 0.0434782608695652 1.29455479927768 0.54443106554377 0.721096474758266 GO:0005212 structural constituent of eye lens 1/626 23/18639 0.0434782608695652 1.29455479927768 0.54443106554377 0.721096474758266 GO:0005283 amino acid:sodium symporter activity 1/626 23/18639 0.0434782608695652 1.29455479927768 0.54443106554377 0.721096474758266 GO:0016849 phosphorus-oxygen lyase activity 1/626 23/18639 0.0434782608695652 1.29455479927768 0.54443106554377 0.721096474758266 GO:0043274 phospholipase binding 1/626 23/18639 0.0434782608695652 1.29455479927768 0.54443106554377 0.721096474758266 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/626 23/18639 0.0434782608695652 1.29455479927768 0.54443106554377 0.721096474758266 GO:0015485 cholesterol binding 2/626 54/18639 0.037037037037037 1.10276890308839 0.545654445848007 0.721096474758266 GO:0051287 NAD binding 2/626 54/18639 0.037037037037037 1.10276890308839 0.545654445848007 0.721096474758266 GO:0046873 metal ion transmembrane transporter activity 15/626 450/18639 0.0333333333333333 0.992492012779553 0.549229886515237 0.724833999890858 GO:0050660 flavin adenine dinucleotide binding 3/626 86/18639 0.0348837209302326 1.0386544319786 0.555330967801398 0.72782568650468 GO:0098632 cell-cell adhesion mediator activity 2/626 55/18639 0.0363636363636364 1.08271855939588 0.5556324573258 0.72782568650468 GO:0004622 lysophospholipase activity 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0005315 phosphate transmembrane transporter activity 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0005540 hyaluronic acid binding 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0015149 hexose transmembrane transporter activity 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0019957 C-C chemokine binding 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0050431 transforming growth factor beta binding 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0055056 D-glucose transmembrane transporter activity 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0060229 lipase activator activity 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/626 24/18639 0.0416666666666667 1.24061501597444 0.559750476425249 0.72782568650468 GO:0042578 phosphoric ester hydrolase activity 12/626 363/18639 0.0330578512396694 0.984289599450796 0.563722484939976 0.732009116990331 GO:0170055 lipid transmembrane transporter activity 2/626 56/18639 0.0357142857142857 1.06338429940666 0.565454008060167 0.733275919543265 GO:0005537 D-mannose binding 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0008483 transaminase activity 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0015645 fatty acid ligase activity 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0015662 P-type ion transporter activity 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0019707 protein-cysteine S-acyltransferase activity 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0042974 nuclear retinoic acid receptor binding 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0120515 fatty acid-CoA ligase activity 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0140358 P-type transmembrane transporter activity 1/626 25/18639 0.04 1.19099041533546 0.574555536954811 0.734999719850198 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/626 57/18639 0.0350877192982456 1.04472843450479 0.575118337491031 0.734999719850198 GO:0046906 tetrapyrrole binding 5/626 152/18639 0.0328947368421053 0.979432907348243 0.581744899481325 0.738882011756792 GO:0008408 3'-5' exonuclease activity 2/626 58/18639 0.0344827586206897 1.02671587528919 0.584624912201781 0.738882011756792 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/626 58/18639 0.0344827586206897 1.02671587528919 0.584624912201781 0.738882011756792 GO:0017116 single-stranded DNA helicase activity 2/626 58/18639 0.0344827586206897 1.02671587528919 0.584624912201781 0.738882011756792 GO:0005112 Notch binding 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0005160 transforming growth factor beta receptor binding 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0005227 calcium-activated cation channel activity 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0008066 glutamate receptor activity 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0008157 protein phosphatase 1 binding 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0015145 monosaccharide transmembrane transporter activity 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0019865 immunoglobulin binding 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0034237 protein kinase A regulatory subunit binding 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0051139 metal cation:proton antiporter activity 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0097602 cullin family protein binding 1/626 26/18639 0.0384615384615385 1.14518309166871 0.58886348977883 0.738882011756792 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/626 122/18639 0.0327868852459016 0.976221651914314 0.589582141339956 0.738882011756792 GO:0005506 iron ion binding 5/626 154/18639 0.0324675324675325 0.966712999460603 0.593384447479954 0.742466764456982 GO:0045309 protein phosphorylated amino acid binding 2/626 59/18639 0.0338983050847458 1.00931391130124 0.593973411565585 0.742466764456982 GO:0005261 monoatomic cation channel activity 11/626 341/18639 0.032258064516129 0.960476141399567 0.597250769482585 0.744362344369138 GO:0015276 ligand-gated monoatomic ion channel activity 6/626 186/18639 0.032258064516129 0.960476141399567 0.597347271299681 0.744362344369138 GO:0061659 ubiquitin-like protein ligase activity 12/626 372/18639 0.032258064516129 0.960476141399567 0.597980314590824 0.744362344369138 GO:0005267 potassium channel activity 4/626 124/18639 0.032258064516129 0.960476141399567 0.602452642635148 0.744362344369138 GO:0008266 poly(U) RNA binding 1/626 27/18639 0.037037037037037 1.10276890308839 0.6026910004111 0.744362344369138 GO:0016405 CoA-ligase activity 1/626 27/18639 0.037037037037037 1.10276890308839 0.6026910004111 0.744362344369138 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/626 27/18639 0.037037037037037 1.10276890308839 0.6026910004111 0.744362344369138 GO:0035255 ionotropic glutamate receptor binding 1/626 27/18639 0.037037037037037 1.10276890308839 0.6026910004111 0.744362344369138 GO:0004714 transmembrane receptor protein tyrosine kinase activity 2/626 60/18639 0.0333333333333333 0.992492012779553 0.603163714097054 0.744362344369138 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/626 60/18639 0.0333333333333333 0.992492012779553 0.603163714097054 0.744362344369138 GO:0022834 ligand-gated channel activity 6/626 188/18639 0.0319148936170213 0.950258310108082 0.607768012861086 0.74909145168393 GO:0051219 phosphoprotein binding 3/626 93/18639 0.032258064516129 0.960476141399567 0.608609302088797 0.749176425160067 GO:0015026 coreceptor activity 2/626 61/18639 0.0327868852459016 0.976221651914314 0.612195884478185 0.749777354108656 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/626 61/18639 0.0327868852459016 0.976221651914314 0.612195884478185 0.749777354108656 GO:0016836 hydro-lyase activity 2/626 61/18639 0.0327868852459016 0.976221651914314 0.612195884478185 0.749777354108656 GO:0019905 syntaxin binding 2/626 61/18639 0.0327868852459016 0.976221651914314 0.612195884478185 0.749777354108656 GO:0005242 inward rectifier potassium channel activity 1/626 28/18639 0.0357142857142857 1.06338429940666 0.616054176520205 0.749777354108656 GO:0046875 ephrin receptor binding 1/626 28/18639 0.0357142857142857 1.06338429940666 0.616054176520205 0.749777354108656 GO:0051019 mitogen-activated protein kinase binding 1/626 28/18639 0.0357142857142857 1.06338429940666 0.616054176520205 0.749777354108656 GO:0051119 sugar transmembrane transporter activity 1/626 28/18639 0.0357142857142857 1.06338429940666 0.616054176520205 0.749777354108656 GO:0141052 histone H3 demethylase activity 1/626 28/18639 0.0357142857142857 1.06338429940666 0.616054176520205 0.749777354108656 GO:0019783 ubiquitin-like protein peptidase activity 4/626 127/18639 0.031496062992126 0.937787728610601 0.621294095015449 0.755073674475385 GO:0003785 actin monomer binding 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0004181 metallocarboxypeptidase activity 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0004629 phospholipase C activity 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0005416 amino acid:monoatomic cation symporter activity 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0016417 S-acyltransferase activity 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0035250 UDP-galactosyltransferase activity 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0043236 laminin binding 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0097472 cyclin-dependent protein kinase activity 1/626 29/18639 0.0344827586206897 1.02671587528919 0.62896858657331 0.755073674475385 GO:0004536 DNA nuclease activity 2/626 64/18639 0.03125 0.930461261980831 0.638346787414145 0.761573806024609 GO:0016298 lipase activity 4/626 130/18639 0.0307692307692308 0.916146473334972 0.639563980907162 0.761573806024609 GO:0001968 fibronectin binding 1/626 30/18639 0.0333333333333333 0.992492012779553 0.641449277857841 0.761573806024609 GO:0022839 monoatomic ion-gated channel activity 1/626 30/18639 0.0333333333333333 0.992492012779553 0.641449277857841 0.761573806024609 GO:0031624 ubiquitin conjugating enzyme binding 1/626 30/18639 0.0333333333333333 0.992492012779553 0.641449277857841 0.761573806024609 GO:0032452 histone demethylase activity 1/626 30/18639 0.0333333333333333 0.992492012779553 0.641449277857841 0.761573806024609 GO:0033612 receptor serine/threonine kinase binding 1/626 30/18639 0.0333333333333333 0.992492012779553 0.641449277857841 0.761573806024609 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/626 30/18639 0.0333333333333333 0.992492012779553 0.641449277857841 0.761573806024609 GO:0051721 protein phosphatase 2A binding 1/626 30/18639 0.0333333333333333 0.992492012779553 0.641449277857841 0.761573806024609 GO:0061630 ubiquitin protein ligase activity 11/626 353/18639 0.0311614730878187 0.927825394383151 0.642772884119217 0.762212344248949 GO:0005249 voltage-gated potassium channel activity 3/626 98/18639 0.0306122448979592 0.911472256634283 0.643964187433219 0.762692627362909 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4/626 132/18639 0.0303030303030303 0.90226546616323 0.651419988858571 0.765280242054441 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 7/626 229/18639 0.0305676855895196 0.910145513902647 0.652628119127709 0.765280242054441 GO:0016758 hexosyltransferase activity 6/626 197/18639 0.0304568527918782 0.906845493910251 0.65276066459799 0.765280242054441 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/626 31/18639 0.032258064516129 0.960476141399567 0.653510793901744 0.765280242054441 GO:0008327 methyl-CpG binding 1/626 31/18639 0.032258064516129 0.960476141399567 0.653510793901744 0.765280242054441 GO:0016878 acid-thiol ligase activity 1/626 31/18639 0.032258064516129 0.960476141399567 0.653510793901744 0.765280242054441 GO:0017147 Wnt-protein binding 1/626 31/18639 0.032258064516129 0.960476141399567 0.653510793901744 0.765280242054441 GO:0047499 calcium-independent phospholipase A2 activity 1/626 31/18639 0.032258064516129 0.960476141399567 0.653510793901744 0.765280242054441 GO:0140457 protein demethylase activity 1/626 31/18639 0.032258064516129 0.960476141399567 0.653510793901744 0.765280242054441 GO:0015103 inorganic anion transmembrane transporter activity 5/626 165/18639 0.0303030303030303 0.90226546616323 0.654038474910445 0.765280242054441 GO:0008235 metalloexopeptidase activity 2/626 66/18639 0.0303030303030303 0.90226546616323 0.654998546958162 0.765480229577611 GO:0000287 magnesium ion binding 7/626 230/18639 0.0304347826086957 0.906188359494374 0.657092603138506 0.767003399572023 GO:0016500 protein-hormone receptor activity 2/626 67/18639 0.0298507462686567 0.888798817414525 0.663092229962487 0.7717848990108 GO:0008378 galactosyltransferase activity 1/626 32/18639 0.03125 0.930461261980831 0.665167191312401 0.7717848990108 GO:0015106 bicarbonate transmembrane transporter activity 1/626 32/18639 0.03125 0.930461261980831 0.665167191312401 0.7717848990108 GO:0022884 macromolecule transmembrane transporter activity 1/626 32/18639 0.03125 0.930461261980831 0.665167191312401 0.7717848990108 GO:0047498 calcium-dependent phospholipase A2 activity 1/626 32/18639 0.03125 0.930461261980831 0.665167191312401 0.7717848990108 GO:0015297 antiporter activity 4/626 135/18639 0.0296296296296296 0.882215122470714 0.668711065207494 0.772125160506141 GO:0005201 extracellular matrix structural constituent 5/626 168/18639 0.0297619047619048 0.886153582838886 0.669540059126897 0.772125160506141 GO:0003777 microtubule motor activity 2/626 68/18639 0.0294117647058824 0.875728246570194 0.671032484852244 0.772125160506141 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 2/626 68/18639 0.0294117647058824 0.875728246570194 0.671032484852244 0.772125160506141 GO:0030145 manganese ion binding 2/626 68/18639 0.0294117647058824 0.875728246570194 0.671032484852244 0.772125160506141 GO:0032934 sterol binding 2/626 68/18639 0.0294117647058824 0.875728246570194 0.671032484852244 0.772125160506141 GO:0140223 general transcription initiation factor activity 2/626 68/18639 0.0294117647058824 0.875728246570194 0.671032484852244 0.772125160506141 GO:0019956 chemokine binding 1/626 33/18639 0.0303030303030303 0.90226546616323 0.676432056053543 0.77623386956776 GO:0030296 protein tyrosine kinase activator activity 1/626 33/18639 0.0303030303030303 0.90226546616323 0.676432056053543 0.77623386956776 GO:0005253 monoatomic anion channel activity 3/626 103/18639 0.029126213592233 0.867226030584075 0.677003972839511 0.77623386956776 GO:0016757 glycosyltransferase activity 8/626 267/18639 0.0299625468164794 0.892127651936677 0.677903737034043 0.776347845245598 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/626 70/18639 0.0285714285714286 0.850707439525331 0.686457439863213 0.782510520661429 GO:0008376 acetylgalactosaminyltransferase activity 1/626 34/18639 0.0294117647058824 0.875728246570194 0.687318519178905 0.782510520661429 GO:0015020 glucuronosyltransferase activity 1/626 34/18639 0.0294117647058824 0.875728246570194 0.687318519178905 0.782510520661429 GO:0015035 protein-disulfide reductase activity 1/626 34/18639 0.0294117647058824 0.875728246570194 0.687318519178905 0.782510520661429 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/626 34/18639 0.0294117647058824 0.875728246570194 0.687318519178905 0.782510520661429 GO:0140030 modification-dependent protein binding 5/626 173/18639 0.0289017341040462 0.860542207612329 0.694345411991561 0.788014079021531 GO:0004497 monooxygenase activity 3/626 106/18639 0.0283018867924528 0.842681897643016 0.695712597367468 0.788014079021531 GO:0000175 3'-5'-RNA exonuclease activity 1/626 35/18639 0.0285714285714286 0.850707439525331 0.697839272040717 0.788014079021531 GO:0004623 phospholipase A2 activity 1/626 35/18639 0.0285714285714286 0.850707439525331 0.697839272040717 0.788014079021531 GO:0005343 organic acid:sodium symporter activity 1/626 35/18639 0.0285714285714286 0.850707439525331 0.697839272040717 0.788014079021531 GO:0034061 DNA polymerase activity 1/626 35/18639 0.0285714285714286 0.850707439525331 0.697839272040717 0.788014079021531 GO:0043015 gamma-tubulin binding 1/626 35/18639 0.0285714285714286 0.850707439525331 0.697839272040717 0.788014079021531 GO:0016791 phosphatase activity 8/626 273/18639 0.0293040293040293 0.872520450795211 0.701480600404265 0.791204863246671 GO:0005496 steroid binding 3/626 108/18639 0.0277777777777778 0.827076677316294 0.707722944522905 0.795789552214164 GO:0005539 glycosaminoglycan binding 7/626 242/18639 0.0289256198347107 0.861253399519447 0.707909683337994 0.795789552214164 GO:0016409 palmitoyltransferase activity 1/626 36/18639 0.0277777777777778 0.827076677316294 0.70800658099054 0.795789552214164 GO:0022843 voltage-gated monoatomic cation channel activity 4/626 143/18639 0.027972027972028 0.83286043030452 0.711892660405265 0.79923134327906 GO:0004620 phospholipase activity 3/626 109/18639 0.0275229357798165 0.819488817891374 0.713590412037312 0.800211213498489 GO:0003684 damaged DNA binding 2/626 74/18639 0.027027027027027 0.804723253605043 0.715523151028901 0.800527631485622 GO:0035064 methylated histone binding 2/626 74/18639 0.027027027027027 0.804723253605043 0.715523151028901 0.800527631485622 GO:0019213 deacetylase activity 1/626 37/18639 0.027027027027027 0.804723253605043 0.717832301589364 0.802185866983506 GO:0000146 microfilament motor activity 1/626 38/18639 0.0263157894736842 0.783546325878594 0.727327892343318 0.809997767592444 GO:0005109 frizzled binding 1/626 38/18639 0.0263157894736842 0.783546325878594 0.727327892343318 0.809997767592444 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/626 38/18639 0.0263157894736842 0.783546325878594 0.727327892343318 0.809997767592444 GO:0098631 cell adhesion mediator activity 2/626 76/18639 0.0263157894736842 0.783546325878594 0.729188285614889 0.810209206238765 GO:0140034 methylation-dependent protein binding 2/626 76/18639 0.0263157894736842 0.783546325878594 0.729188285614889 0.810209206238765 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 5/626 181/18639 0.0276243093922652 0.822507192911231 0.731316420724816 0.811644082497794 GO:0051540 metal cluster binding 2/626 77/18639 0.025974025974026 0.773370399568483 0.735809735681203 0.815697649840877 GO:0008509 monoatomic anion transmembrane transporter activity 4/626 149/18639 0.0268456375838926 0.79932242639964 0.74147951613954 0.818036361063703 GO:0019199 transmembrane receptor protein kinase activity 2/626 78/18639 0.0256410256410256 0.76345539444581 0.742292787494256 0.818036361063703 GO:0005216 monoatomic ion channel activity 13/626 448/18639 0.0290178571428571 0.863999743267914 0.743525164387858 0.818036361063703 GO:0004532 RNA exonuclease activity 1/626 40/18639 0.025 0.744369009584665 0.745372612286407 0.818036361063703 GO:0015036 disulfide oxidoreductase activity 1/626 40/18639 0.025 0.744369009584665 0.745372612286407 0.818036361063703 GO:0015144 carbohydrate transmembrane transporter activity 1/626 40/18639 0.025 0.744369009584665 0.745372612286407 0.818036361063703 GO:0030331 nuclear estrogen receptor binding 1/626 40/18639 0.025 0.744369009584665 0.745372612286407 0.818036361063703 GO:0017124 SH3 domain binding 3/626 115/18639 0.0260869565217391 0.776732879566606 0.746895130802108 0.818036361063703 GO:0035401 histone H3Y41 kinase activity 3/626 115/18639 0.0260869565217391 0.776732879566606 0.746895130802108 0.818036361063703 GO:0140801 histone H2AXY142 kinase activity 3/626 115/18639 0.0260869565217391 0.776732879566606 0.746895130802108 0.818036361063703 GO:0009055 electron transfer activity 3/626 116/18639 0.0258620689655172 0.770036906466894 0.752134278292861 0.818036361063703 GO:0001727 lipid kinase activity 1/626 41/18639 0.024390243902439 0.726213667887478 0.753942790506135 0.818036361063703 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/626 41/18639 0.024390243902439 0.726213667887478 0.753942790506135 0.818036361063703 GO:0008227 G protein-coupled amine receptor activity 1/626 41/18639 0.024390243902439 0.726213667887478 0.753942790506135 0.818036361063703 GO:0017080 sodium channel regulator activity 1/626 41/18639 0.024390243902439 0.726213667887478 0.753942790506135 0.818036361063703 GO:0042169 SH2 domain binding 1/626 41/18639 0.024390243902439 0.726213667887478 0.753942790506135 0.818036361063703 GO:0042287 MHC protein binding 1/626 41/18639 0.024390243902439 0.726213667887478 0.753942790506135 0.818036361063703 GO:0140318 protein transporter activity 1/626 41/18639 0.024390243902439 0.726213667887478 0.753942790506135 0.818036361063703 GO:0140828 metal cation:monoatomic cation antiporter activity 1/626 41/18639 0.024390243902439 0.726213667887478 0.753942790506135 0.818036361063703 GO:0031492 nucleosomal DNA binding 1/626 42/18639 0.0238095238095238 0.708922866271109 0.762224961338652 0.82609856145083 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/626 43/18639 0.0232558139534884 0.692436287985734 0.77022878852594 0.833841434006878 GO:0005254 chloride channel activity 2/626 83/18639 0.0240963855421687 0.717464105623773 0.772696554307752 0.835580443342831 GO:0015108 chloride transmembrane transporter activity 3/626 121/18639 0.0247933884297521 0.738217199588097 0.777033347234996 0.837069454831995 GO:0001223 transcription coactivator binding 1/626 44/18639 0.0227272727272727 0.676699099622422 0.777963612056956 0.837069454831995 GO:0003954 NADH dehydrogenase activity 1/626 44/18639 0.0227272727272727 0.676699099622422 0.777963612056956 0.837069454831995 GO:0019205 nucleobase-containing compound kinase activity 1/626 44/18639 0.0227272727272727 0.676699099622422 0.777963612056956 0.837069454831995 GO:0004527 exonuclease activity 2/626 84/18639 0.0238095238095238 0.708922866271109 0.77838829717367 0.837069454831995 GO:0008236 serine-type peptidase activity 5/626 194/18639 0.0257731958762887 0.767390731530582 0.784283226553302 0.842474783783724 GO:0051539 4 iron, 4 sulfur cluster binding 1/626 45/18639 0.0222222222222222 0.661661341853035 0.78543845899712 0.842782417286732 GO:0017171 serine hydrolase activity 5/626 198/18639 0.0252525252525253 0.751887888469358 0.798852517737501 0.852667325908834 GO:0001784 phosphotyrosine residue binding 1/626 47/18639 0.0212765957446809 0.633505540072055 0.799642829206139 0.852667325908834 GO:0061749 forked DNA-dependent helicase activity 1/626 47/18639 0.0212765957446809 0.633505540072055 0.799642829206139 0.852667325908834 GO:0099095 ligand-gated monoatomic anion channel activity 1/626 47/18639 0.0212765957446809 0.633505540072055 0.799642829206139 0.852667325908834 GO:0016651 oxidoreductase activity, acting on NAD(P)H 2/626 88/18639 0.0227272727272727 0.676699099622422 0.799923579663996 0.852667325908834 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 7/626 268/18639 0.0261194029850746 0.777698965237709 0.799925017089731 0.852667325908834 GO:0009378 four-way junction helicase activity 1/626 48/18639 0.0208333333333333 0.62030750798722 0.806388934462 0.857672441258926 GO:0036121 double-stranded DNA helicase activity 1/626 48/18639 0.0208333333333333 0.62030750798722 0.806388934462 0.857672441258926 GO:0001222 transcription corepressor binding 1/626 49/18639 0.0204081632653061 0.607648171089522 0.812908246334776 0.86365936357583 GO:0016874 ligase activity 4/626 167/18639 0.0239520958083832 0.713167913374529 0.816360901468606 0.866378637225982 GO:0043178 alcohol binding 2/626 92/18639 0.0217391304347826 0.647277399638839 0.819583351311183 0.867899400405947 GO:0052689 carboxylic ester hydrolase activity 2/626 92/18639 0.0217391304347826 0.647277399638839 0.819583351311183 0.867899400405947 GO:1901681 sulfur compound binding 7/626 275/18639 0.0254545454545455 0.757902991577113 0.820512847410821 0.867936163564337 GO:0051213 dioxygenase activity 2/626 93/18639 0.021505376344086 0.640317427599711 0.824220143601785 0.870907994873345 GO:0001217 DNA-binding transcription repressor activity 7/626 278/18639 0.0251798561151079 0.749724182315489 0.828815600825147 0.874810808270286 GO:0008276 protein methyltransferase activity 2/626 95/18639 0.0210526315789474 0.626837060702875 0.83317377455572 0.877647451446943 GO:0008146 sulfotransferase activity 1/626 53/18639 0.0188679245283019 0.561787931762011 0.836866036831216 0.877647451446943 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/626 53/18639 0.0188679245283019 0.561787931762011 0.836866036831216 0.877647451446943 GO:0017046 peptide hormone binding 1/626 53/18639 0.0188679245283019 0.561787931762011 0.836866036831216 0.877647451446943 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/626 53/18639 0.0188679245283019 0.561787931762011 0.836866036831216 0.877647451446943 GO:0005244 voltage-gated monoatomic ion channel activity 4/626 173/18639 0.023121387283237 0.688433766089863 0.836992908145791 0.877647451446943 GO:0016779 nucleotidyltransferase activity 3/626 136/18639 0.0220588235294118 0.656796184927645 0.839611919677664 0.877647451446943 GO:0140789 histone phosphatase activity 3/626 136/18639 0.0220588235294118 0.656796184927645 0.839611919677664 0.877647451446943 GO:0030594 neurotransmitter receptor activity 2/626 97/18639 0.0206185567010309 0.613912585224466 0.841713835422544 0.877647451446943 GO:0031267 small GTPase binding 7/626 283/18639 0.0247349823321555 0.73647817202723 0.841978589913943 0.877647451446943 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 1/626 54/18639 0.0185185185185185 0.551384451544196 0.842360595151654 0.877647451446943 GO:0017069 snRNA binding 1/626 54/18639 0.0185185185185185 0.551384451544196 0.842360595151654 0.877647451446943 GO:0022832 voltage-gated channel activity 4/626 175/18639 0.0228571428571429 0.680565951620265 0.843425350601723 0.877813937858016 GO:0008374 O-acyltransferase activity 1/626 55/18639 0.0181818181818182 0.541359279697938 0.847670375481762 0.881286456824555 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/626 56/18639 0.0178571428571429 0.531692149703332 0.852801582162155 0.885671878690889 GO:0031593 polyubiquitin modification-dependent protein binding 1/626 59/18639 0.0169491525423729 0.50465695565062 0.867182725221084 0.898682952419286 GO:0070888 E-box binding 1/626 59/18639 0.0169491525423729 0.50465695565062 0.867182725221084 0.898682952419286 GO:0008194 UDP-glycosyltransferase activity 3/626 145/18639 0.0206896551724138 0.616029525173515 0.869380859051255 0.899999395175792 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/626 60/18639 0.0166666666666667 0.496246006389776 0.871657623714712 0.901394344353167 GO:0008234 cysteine-type peptidase activity 4/626 187/18639 0.0213903743315508 0.636893270232868 0.87767892370308 0.906654479224694 GO:0022824 transmitter-gated monoatomic ion channel activity 1/626 63/18639 0.0158730158730159 0.472615244180739 0.884199157496555 0.910481085744861 GO:0022835 transmitter-gated channel activity 1/626 63/18639 0.0158730158730159 0.472615244180739 0.884199157496555 0.910481085744861 GO:1901682 sulfur compound transmembrane transporter activity 1/626 63/18639 0.0158730158730159 0.472615244180739 0.884199157496555 0.910481085744861 GO:0098960 postsynaptic neurotransmitter receptor activity 1/626 69/18639 0.0144927536231884 0.431518266425892 0.905730112335015 0.931662999962847 GO:0016782 transferase activity, transferring sulphur-containing groups 1/626 70/18639 0.0142857142857143 0.425353719762665 0.908907977153447 0.933941459575046 GO:0140299 molecular sensor activity 1/626 71/18639 0.0140845070422535 0.419362822301219 0.911978880610927 0.936023661805243 GO:0022836 gated channel activity 7/626 318/18639 0.0220125786163522 0.655419253722346 0.912864313471918 0.936023661805243 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/626 73/18639 0.0136986301369863 0.407873429909405 0.917814061091787 0.940105215690637 GO:0005516 calmodulin binding 4/626 207/18639 0.0193236714975845 0.575357688567857 0.920431283549631 0.940956390269071 GO:0031491 nucleosome binding 1/626 74/18639 0.0135135135135135 0.402361626802521 0.920585169448813 0.940956390269071 GO:0051536 iron-sulfur cluster binding 1/626 76/18639 0.0131578947368421 0.391773162939297 0.92585064974448 0.94534224237068 GO:0008201 heparin binding 3/626 172/18639 0.0174418604651163 0.519327215989301 0.931460361782438 0.950069979946336 GO:0016741 transferase activity, transferring one-carbon groups 4/626 215/18639 0.0186046511627907 0.553949030388588 0.933397605479638 0.951045879532825 GO:0000049 tRNA binding 1/626 80/18639 0.0125 0.372184504792332 0.935358857465017 0.952044167619168 GO:0008237 metallopeptidase activity 3/626 184/18639 0.016304347826087 0.485458049729129 0.94915198114934 0.965070672657086 GO:0004197 cysteine-type endopeptidase activity 1/626 88/18639 0.0113636363636364 0.338349549811211 0.950878325924573 0.96581358758831 GO:0005125 cytokine activity 4/626 234/18639 0.0170940170940171 0.508970262963873 0.95686787327775 0.970090638086111 GO:0045182 translation regulator activity 7/626 356/18639 0.0196629213483146 0.585458771583444 0.957089423348875 0.970090638086111 GO:0004867 serine-type endopeptidase inhibitor activity 1/626 95/18639 0.0105263157894737 0.313418530351438 0.961372299244905 0.9734145409891 GO:0004896 cytokine receptor activity 1/626 96/18639 0.0104166666666667 0.31015375399361 0.962676275769532 0.973718443687639 GO:0008170 N-methyltransferase activity 1/626 98/18639 0.0102040816326531 0.303824085544761 0.96515385460666 0.975207540592146 GO:0140375 immune receptor activity 2/626 156/18639 0.0128205128205128 0.381727697222905 0.969348414433016 0.977569703093024 GO:0008168 methyltransferase activity 3/626 204/18639 0.0147058823529412 0.437864123285097 0.96950727255205 0.977569703093024 GO:0008083 growth factor activity 2/626 162/18639 0.0123456790123457 0.367589634362797 0.974255913493435 0.981337732179264 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/626 167/18639 0.0119760479041916 0.356583956687264 0.97775771671332 0.983843345655519 GO:0004252 serine-type endopeptidase activity 2/626 176/18639 0.0113636363636364 0.338349549811211 0.982934204655659 0.988001636133074 GO:0005126 cytokine receptor binding 4/626 275/18639 0.0145454545454545 0.43308742375835 0.983927402582009 0.988001636133074 GO:0005179 hormone activity 1/626 132/18639 0.00757575757575758 0.225566366540807 0.989172220448042 0.992241007067839 GO:0140101 catalytic activity, acting on a tRNA 1/626 139/18639 0.00719424460431655 0.214206909232997 0.991490332401523 0.993538866146154 GO:0030371 translation repressor activity 4/626 329/18639 0.0121580547112462 0.36200316575546 0.995966988689516 0.996994818399206 GO:0004175 endopeptidase activity 5/626 405/18639 0.0123456790123457 0.367589634362797 0.998021981097888 0.998021981097888