category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	24/113	368/9376	5.4113120430935	MT-CO1/TUBB4B/SRSF3/SRSF7/MT-CO3/HSPA5/HNRNPA1/TUBA1B/MT-ATP6/ACTG1/ACTB/MT-ND2/CYCS/TUBA4A/TUBB2A/FUS/MAP1LC3B/MT-CO2/SOD1/HNRNPA2B1/XBP1/TNF/NXT1/PFN1	9.53512801434936
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/113	82/9376	11.1305849341679	B2M/HSPA1A/HSPA1B/HSPA5/HSP90AB1/HSPA8/HSP90AA1/HLA-C/CALR/TNF/HSPA2	10.1762822018428
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/113	275/9376	5.43098954143202	MT-CO1/TUBB4B/HSPA1A/MT-CO3/HSPA1B/HSPA5/TUBA1B/MT-ATP6/HSPA8/MT-ND2/CYCS/TUBA4A/TUBB2A/VDAC2/PIK3R3/MT-CO2/SOD1/TNF	8.23704697270357
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	17/113	268/9376	5.26324131554616	MT-CO1/TUBB4B/UBB/UBC/MT-CO3/HSPA5/DUSP1/TUBA1B/MT-ATP6/MT-ND2/CYCS/TUBA4A/TUBB2A/VDAC2/MT-CO2/SOD1/XBP1	7.82068565179106
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	20/113	480/9376	3.45722713864307	MT-CO1/TUBB4B/UBB/UBC/MT-CO3/HSPA5/TUBA1B/MT-ATP6/MT-ND2/CYCS/TUBA4A/TUBB2A/VDAC2/FUS/MAP1LC3B/MT-CO2/SOD1/XBP1/TNF/DKK1	6.10404269554472
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	12/113	174/9376	5.72230698809887	DNAJA1/HSPA1A/HSPA1B/DNAJB1/HSPA5/HERPUD1/HSP90AB1/HSPA8/HSP90AA1/UBE2D3/CALR/XBP1	6.94443238782898
Genetic Information Processing	Transcription	hsa03040	Spliceosome	14/113	243/9376	4.78036345096325	SRSF2/SRSF3/HSPA1A/SRSF7/EIF4A3/HSPA1B/HNRNPA1/HSPA8/DDX5/SRSF5/BCAS2/FUS/RBM8A/PCBP1	6.59445625385999
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	14/113	248/9376	4.68398515558093	TUBB4B/DYNLL1/FOS/MYL12A/TUBA1B/HSP90AB1/ACTG1/HSP90AA1/ACTB/CYCS/TUBA4A/TUBB2A/TNF/PFN1	6.49388994539087
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	13/113	216/9376	4.99377253359554	HSPA1A/HSPA1B/HSPA5/FOS/HSP90AB1/HSPA8/HSP90AA1/CYCS/PIK3R3/HSPD1/XBP1/TNF/HSPA2	6.55860525313498
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/113	56/9376	10.3716814159292	HSPA1A/HSPA1B/HSPA8/CLK1/CYCS/HSPD1/TNF	7.76877604313416
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/113	137/9376	6.05645630127253	GADD45B/FOS/TUBA1B/ACTG1/ACTB/CYCS/TUBA4A/GADD45A/PIK3R3/TNF	6.58480754476097
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/113	142/9376	5.84320079770659	FOS/DUSP1/HSP90AB1/ACTG1/HSP90AA1/ACTB/GSTP1/PIK3R3/TNF/SUMO2	6.42289378457372
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/113	42/9376	11.8533501896334	FTL/SAT1/VDAC2/MAP1LC3B/PCBP1/SLC3A2	7.78580622764273
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/113	180/9376	5.07059980334317	B2M/SRSF2/SRSF3/SRSF7/HLA-C/SRSF5/CYCS/PIK3R3/CALR/SOCS3/TNF	6.09037741724853
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	15/113	388/9376	3.20773652039048	MT-CO1/TUBB4B/MT-CO3/TUBA1B/MT-ATP6/MT-ND2/CYCS/TUBA4A/TUBB2A/VDAC2/PIK3R3/MT-CO2/XBP1/TNF/DKK1	4.90546973535306
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/113	157/9376	4.75643988501212	MT-CO1/MT-CO3/FOS/CYCS/PIK3R3/MT-CO2/SOCS3/XBP1/TNF	5.24243904792155
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	11/113	253/9376	3.60754136206233	UBB/UBC/MYL12A/ACTG1/ACTB/CYCS/UBE2D3/MAP1LC3B/PIK3R3/TNF/PFN1	4.6437802186057
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	12/113	308/9376	3.23273186990001	MT-CO1/TUBB4B/MT-CO3/TUBA1B/MT-ATP6/MT-ND2/CYCS/TUBA4A/TUBB2A/VDAC2/MT-CO2/SOD1	4.40053218741024
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	10/113	224/9376	3.70417193426043	B2M/ZFP36/FOS/HLA-C/RAN/VDAC2/PIK3R3/CALR/TNF/LCK	4.52427851654064
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/113	155/9376	4.28250071367399	TUBB4B/TUBA1B/ACTG1/HLA-C/ACTB/TUBA4A/TUBB2A/CALR	4.55125003387777
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/113	200/9376	3.73380530973451	TUBB4B/FOS/TUBA1B/ACTG1/ACTB/CYCS/TUBA4A/TUBB2A/TNF	4.31623324989437
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	9/113	204/9376	3.66059344091619	FN1/ACTG1/ACTB/DDX5/LUM/DCN/PIK3R3/TNF/CD63	4.24336709843561
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	9/113	205/9376	3.64273688754587	B2M/GADD45B/HLA-C/CYCS/GADD45A/PIK3R3/CALR/TNF/ISG15	4.2254361000207
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/113	62/9376	6.69140736511561	HSPA1A/HSPA1B/HSPA8/PIK3R3/SOD1	4.96588236409976
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/113	93/9376	5.35312589209249	GADD45B/FN1/CKS2/CYCS/GADD45A/PIK3R3	4.65958838549162
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/113	300/9376	3.0423598820059	DUSP2/GADD45B/HSPA1A/HSPA1B/FOS/DUSP1/HSPA8/GADD45A/NR4A1/TNF/MKNK2	3.97095241402634
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/113	173/9376	3.83692260473681	DNAJB1/ACTG1/ACTB/CYCS/PIK3R3/SOCS3/TNF/NXT1	4.15963147979609
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/113	138/9376	4.20879825573939	FN1/FOS/ACTG1/ACTB/PIK3R3/TNF/LCK	4.19413113433419
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/113	139/9376	4.17851913159738	HSPA1A/HSPA1B/FOS/HSP90AB1/HSPA8/HSP90AA1/PIK3R3	4.16980538667066
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/113	142/9376	4.09024055839461	JUNB/FOS/SOCS1/PIK3R3/SOCS3/TNF/LCK	4.0981755050811
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/113	227/9376	3.28969630813614	MT-CO1/MT-CO3/FOS/MT-ATP6/MT-ND2/VDAC2/PIK3R3/MT-CO2/SOD1	3.85703008687983
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/113	108/9376	4.60963618485742	SAP18/EIF4A3/RAN/RBM8A/SUMO2/NXT1	4.16707507310822
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/113	112/9376	4.44500632111252	HSPA1A/HSPA1B/HSPA8/SOCS1/CYCS/TNF	4.05087450600982
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/113	194/9376	3.42158562174984	TUBB4B/DYNLL1/MYL12A/TUBA1B/ACTG1/ACTB/TUBA4A/TUBB2A	3.76427269948295
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/113	47/9376	7.06157032573903	SOCS1/PIK3R3/SOCS3/TNF	4.60114117245185
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/113	196/9376	3.38667148275239	UBB/ZFP36/UBC/FOS/HLA-C/CYCS/MAP1LC3B/PIK3R3	3.72948072509423
NA	NA	hsa04517	IgSF CAM signaling	10/113	299/9376	2.77503181697102	TUBB4B/DYNLL1/MYL12A/TUBA1B/ACTG1/ACTB/TUBA4A/TUBB2A/PIK3R3/LCK	3.44524091705203
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/113	87/9376	4.76858915674906	GADD45B/FOS/CYCS/GADD45A/PIK3R3	3.90034449084967
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/113	214/9376	3.10181126457696	B2M/FOS/HLA-C/CYCS/PIK3R3/CALR/CFL1/TNF	3.43521945091005
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/113	133/9376	3.74316321777896	ULBP2/NCR3/HLA-C/PIK3R3/TNF/LCK	3.51900610848077
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/113	136/9376	3.66059344091619	HSPA1A/HSPA1B/FOS/HSPA8/CYCS/PIK3R3	3.45192230835746
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/113	138/9376	3.60754136206233	MT-CO1/MT-CO3/MT-ATP6/MT-ND2/CYCS/MT-CO2	3.40824493753341
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/113	232/9376	2.86115349404944	FN1/MYL12A/ACTG1/TMSB4X/ACTB/PIK3R3/CFL1/PFN1	3.17034922311488
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/113	142/9376	3.50592047862396	UBB/UBE2S/UBC/SOCS1/UBE2D3/SOCS3	3.32326941191689
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/113	103/9376	4.0278374430793	SAP18/EIF4A3/FUS/RBM8A/NXT1	3.41263676858163
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/113	70/9376	4.74134007585335	ACTG1/HLA-C/ACTB/CYCS	3.47011373913964
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/113	71/9376	4.67456063816527	FOS/SOCS1/PIK3R3/SOCS3	3.43261765695338
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/113	205/9376	2.83323980142456	MT-CO1/MT-CO3/MT-ATP6/MT-ND2/VDAC2/PIK3R3/MT-CO2	2.93114220845782
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/113	119/9376	3.48627946753923	JUNB/FOS/PIK3R3/SOCS3/TNF	3.0146529310977
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/113	78/9376	4.25504878602224	FN1/ACTG1/ACTB/PIK3R3	3.18829912817568
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/113	44/9376	5.65728077232502	HLA-C/HSPD1/TNF	3.41995523943795
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/113	122/9376	3.40055128391121	JUNB/FOS/SOCS1/PIK3R3/SOCS3	2.94764504107843
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/113	168/9376	2.96333754740834	FTL/HSP90AB1/HSP90AA1/VDAC2/TNF/CHMP1B	2.83606372949409
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/113	170/9376	2.92847475273295	GADD45B/ACTG1/ACTB/GSTP1/GADD45A/PIK3R3	2.80254090962668
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/113	50/9376	4.97840707964602	SAT1/AMD1/ODC1	3.1152689291741
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/113	89/9376	3.72914387988466	TUBB4B/TUBA1B/TUBA4A/TUBB2A	2.85714802152185
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/113	235/9376	2.47154961400866	MT-CO1/MT-CO3/MT-ATP6/ACTG1/ACTB/MT-ND2/MT-CO2	2.52325425168332
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/113	187/9376	2.66224977521177	HSP90AB1/HSP90AA1/TXNIP/VDAC2/MAP1LC3B/TNF	2.53589920949309
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/113	94/9376	3.53078516286952	FOS/HSP90AB1/HSP90AA1/TNF	2.72362588087316
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/113	59/9376	4.21898905054747	GADD45B/GADD45A/PIK3R3	2.73940652213824
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/113	103/9376	3.22226995446344	FOS/PIK3R3/CALR/TNF	2.50469197864316
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/113	103/9376	3.22226995446344	FN1/PRDX1/PIK3R3/TNF	2.50469197864316
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/113	105/9376	3.16089338390223	GADD45B/GADD45A/TNF/LCK	2.45931255392713
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/113	105/9376	3.16089338390223	UBB/UBC/CITED2/MAP1LC3B	2.45931255392713
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/113	106/9376	3.1310736349975	HSP90AB1/HSP90AA1/GSTP1/PIK3R3	2.43702817188211
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/113	157/9376	2.64246660278451	GADD45B/HLA-C/GADD45A/VDAC2/PIK3R3	2.29220520410825
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/113	158/9376	2.62574213061499	DDIT4/PIK3R3/SLC3A2/TNF/SGK1	2.2762024160671
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/113	109/9376	3.04489729641958	FOS/HSP90AB1/HSP90AA1/LCK	2.37172426099016
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/113	30/9376	5.53156342182891	DHFR/TNF	2.74564781564983
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/113	116/9376	2.86115349404944	MYL12A/ACTG1/ACTB/PIK3R3	2.22768982475952
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/113	169/9376	2.45483583808975	UBB/DDIT4/UBC/MAP1LC3B/PIK3R3	2.10788687403233
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/113	170/9376	2.44039562727746	MYL12A/TUBA1B/ACTG1/ACTB/TUBA4A	2.09324372319198
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/113	227/9376	2.19313087209076	B2M/HLA-C/CYCS/PIK3R3/CALR/TNF	2.00984805490878
Human Diseases	Immune disease	hsa05310	Asthma	2/113	32/9376	5.1858407079646	PRG2/TNF	2.61963207571084
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/113	73/9376	3.40986786277124	GADD45B/GADD45A/PIK3R3	2.28292780483831
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/113	73/9376	3.40986786277124	GADD45B/GADD45A/PIK3R3	2.28292780483831
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/113	122/9376	2.72044102712897	FOS/PIK3R3/TNF/LCK	2.11253535638781
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/113	75/9376	3.31893805309735	CYCS/GSTP1/PIK3R3	2.22691676447193
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/113	75/9376	3.31893805309735	GADD45B/CYCS/GADD45A	2.22691676447193
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/113	76/9376	3.27526781555659	GADD45B/GADD45A/PIK3R3	2.19961601681422
Organismal Systems	Immune system	hsa04611	Platelet activation	4/113	126/9376	2.63407781991853	MYL12A/ACTG1/ACTB/PIK3R3	2.03955851268379
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/113	77/9376	3.23273186990001	GADD45B/GADD45A/PIK3R3	2.17276540696736
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/113	77/9376	3.23273186990001	GADD45B/GADD45A/PIK3R3	2.17276540696736
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/113	78/9376	3.19128658951668	FOS/CFL1/TNF	2.14635097112531
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/113	37/9376	4.48505142310452	GADD45B/GADD45A	2.34589674622998
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/113	38/9376	4.36702375407545	PIK3R3/SGK1	2.29699511580398
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/113	133/9376	2.49544214518597	GADD45B/GADD45A/PIK3R3/SGK1	1.91839479681047
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/113	39/9376	4.25504878602224	HLA-C/TNF	2.24975462911934
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/113	250/9376	1.99136283185841	HSPA1A/HSPA1B/ARF4/HSPA8/HLA-C/CHMP1B	1.75473457063646
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/113	138/9376	2.40502757470822	SOCS1/PIK3R3/SOCS3/MKNK2	1.83647254393185
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/113	87/9376	2.86115349404944	MT-CO1/MT-CO3/MT-CO2	1.92622211528183
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/113	90/9376	2.76578171091445	FOS/PIK3R3/LCK	1.85905807666669
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/113	201/9376	2.06401620217497	GADD45B/DDX5/GADD45A/FUS/ID2	1.68419456427757
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/113	144/9376	2.30481809242871	CYCS/VDAC2/PIK3R3/XBP1	1.74273898317412
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/113	44/9376	3.77152051488335	DYNLL1/AQP3	2.0351953359585
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/113	203/9376	2.04368106717817	FN1/MYL12A/ACTG1/ACTB/PIK3R3	1.66038635372267
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/113	93/9376	2.67656294604625	MYL12A/ACTG1/ACTB	1.7945939135676
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/113	45/9376	3.68770894788594	HLA-C/TNF	1.99605924417413
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/113	148/9376	2.24252571155226	GADD45B/FOS/GADD45A/PIK3R3	1.68279602325588
NA	NA	hsa03272	Virion - Hepatitis viruses	2/113	48/9376	3.45722713864307	CHMP1B/CD63	1.88504048117477
NA	NA	hsa04518	Integrin signaling	4/113	154/9376	2.15515457993334	FN1/ACTG1/ACTB/PIK3R3	1.59638240974561
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/113	99/9376	2.51434700992223	ACTG1/ACTB/TNF	1.67297037792089
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/113	156/9376	2.12752439301112	CYCS/PIK3R3/SOCS3/TNF	1.56845409633845
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/113	157/9376	2.11397328222761	DUSP2/CALR/ODC1/SGK1	1.55464674315492
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/113	217/9376	1.91183067574732	FOS/HSP90AB1/HSP90AA1/PIK3R3/PTGES3	1.50095981105721
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/113	50/9376	3.31893805309735	KLRB1/TNF	1.81583119094399
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/113	101/9376	2.4645579602208	FN1/PIK3R3/TNF	1.6344036342732
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/113	51/9376	3.25386083636995	ACTG1/ACTB	1.78252977498415
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/113	105/9376	2.37067003792668	ACTG1/ACTB/TNF	1.55995943931187
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/113	163/9376	2.03615831478365	FOS/CYCS/PIK3R3/TNF	1.47390133063314
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/113	55/9376	3.01721641190668	GLA/NEU1	1.65711104336833
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/113	109/9376	2.28367297231469	FOS/PIK3R3/TNF	1.48883679241337
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/113	109/9376	2.28367297231469	PIK3R3/SOCS3/TNF	1.48883679241337
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/113	362/9376	1.60445900356916	DDIT4/FN1/HSP90AB1/HSP90AA1/PIK3R3/NR4A1/SGK1	1.29542235451964
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/113	110/9376	2.26291230893001	DCN/TNF/ID2	1.47154117542246
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/113	110/9376	2.26291230893001	HSP90AB1/HSP90AA1/PIK3R3	1.47154117542246
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/113	233/9376	1.78054616582476	FN1/MYOM2/ACTG1/ACTB/DCN	1.33254297255752
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/113	59/9376	2.81265936703165	GSTP1/ODC1	1.54259949769539
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	5/113	238/9376	1.74313973376961	RPL14/FOS/PIK3R3/TNF/ISG15	1.28257394197279
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/113	63/9376	2.63407781991853	GADD45B/GADD45A	1.43729937365533
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/113	16/9376	5.1858407079646	GLA	1.85077571444557
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/113	122/9376	2.04033077034673	ACTG1/ACTB/PIK3R3	1.27742567169719
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/113	18/9376	4.60963618485742	NEU1	1.69300091029374
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/113	18/9376	4.60963618485742	PRDX1	1.69300091029374
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/113	69/9376	2.40502757470822	PIK3R3/TNF	1.29375953632159
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/113	70/9376	2.37067003792668	SOCS3/TNF	1.27130408730661
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/113	195/9376	1.70201951440889	ACTG1/ACTB/VDAC2/PIK3R3	1.09413402684048
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/113	72/9376	2.30481809242871	TNF/ISG15	1.22752513964689
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/113	76/9376	2.18351187703773	ACTG1/ACTB	1.14416055245137
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/113	78/9376	2.12752439301112	TOB1/HSPD1	1.10440281407494
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/113	78/9376	2.12752439301112	FOS/TNF	1.10440281407494
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	4/113	212/9376	1.56553681749875	ACTG1/ACTB/PIK3R3/PFN1	0.919888737503371
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/113	83/9376	1.99936027295021	PRDX1/SOD1	1.01002514694204
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/113	150/9376	1.65946902654867	GADD45B/GADD45A/PIK3R3	0.899253910455721
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/113	86/9376	1.92961514714962	ACTG1/ACTB	0.95651897114304
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/113	27/9376	3.07309078990495	ELOVL5	1.19142484508508
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/113	154/9376	1.61636593495001	FOS/ACTG1/ACTB	0.851795728133094
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/113	28/9376	2.96333754740834	ELOVL5	1.14911545033513
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/113	28/9376	2.96333754740834	DHFR	1.14911545033513
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/113	157/9376	1.58547996167071	ACTG1/ACTB/ID2	0.817088282201599
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/113	158/9376	1.57544527836899	GADD45B/GADD45A/CDKN1C	0.805681238292336
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/113	91/9376	1.82359233686667	FOS/PIK3R3	0.871948966192767
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/113	93/9376	1.78437529736416	FOS/LCK	0.839595756259589
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/113	31/9376	2.67656294604625	HSPA5	1.03266649260521
NA	NA	hsa04981	Folate transport and metabolism	1/113	31/9376	2.67656294604625	DHFR	1.03266649260521
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/113	95/9376	1.74680950163018	FOS/TNF	0.808022174120715
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/113	32/9376	2.5929203539823	GLA	0.99690015566163
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/113	32/9376	2.5929203539823	CYCS	0.99690015566163
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/113	168/9376	1.48166877370417	SOCS1/PIK3R3/SOCS3	0.695776098478589
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/113	98/9376	1.6933357413762	PIK3R3/CFL1	0.762041231641011
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/113	99/9376	1.67623133994815	FOS/PIK3R3	0.747064571688305
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/113	99/9376	1.67623133994815	FOS/PIK3R3	0.747064571688305
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/113	34/9376	2.44039562727746	BHLHE40	0.929288043110907
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/113	103/9376	1.61113497723172	SLC38A2/SLC3A2	0.688802398766241
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/113	105/9376	1.58044669195112	PIK3R3/TNF	0.660606324696601
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/113	37/9376	2.24252571155226	TNF	0.836382787500155
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/113	38/9376	2.18351187703773	NAPRT	0.807395848562444
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/113	38/9376	2.18351187703773	LCK	0.807395848562444
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/113	181/9376	1.37525057448785	CYCS/HSPD1/TNF	0.563032953681967
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	5/113	333/9376	1.24584761752903	FN1/HLA-C/PIK3R3/TNF/ISG15	0.504522899792593
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/113	39/9376	2.12752439301112	DHFR	0.779298065674032
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/113	184/9376	1.35282801077337	MYL12A/PIK3R3/CFL1	0.533845993556979
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/113	110/9376	1.50860820595334	PIK3R3/MKNK2	0.592628571220589
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/113	115/9376	1.44301654482493	FOS/PIK3R3	0.527945328758548
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/113	115/9376	1.44301654482493	FOS/SGK1	0.527945328758548
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/113	117/9376	1.41834959534075	ACTG1/ACTB	0.502920420474013
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/113	44/9376	1.88576025744167	MBD4	0.650435432479043
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/113	46/9376	1.80377068103117	FTL	0.603558377466365
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/113	48/9376	1.72861356932153	PIK3R3	0.558949578451584
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/113	125/9376	1.32757522123894	PIK3R3/TNF	0.407212158787554
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/113	130/9376	1.27651463580667	FOS/PIK3R3	0.350640343257849
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/113	52/9376	1.59564329475834	VDAC2	0.475702927984844
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/113	54/9376	1.53654539495247	AMD1	0.436714719706021
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/113	54/9376	1.53654539495247	HLA-C	0.436714719706021
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/113	57/9376	1.45567458469182	ELOVL5	0.381115495075191
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/113	59/9376	1.40632968351582	NUDT2	0.345792473252528
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/113	59/9376	1.40632968351582	PIK3R3	0.345792473252528
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/113	60/9376	1.38289085545723	PIK3R3	0.328613126526287
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/113	144/9376	1.15240904621436	PIK3R3/ID2	0.203560318305945
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/113	61/9376	1.36022051356449	FTL	0.311738870025918
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/113	63/9376	1.31703890995926	PTGES3	0.278860542107804
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/113	63/9376	1.31703890995926	ERCC5	0.278860542107804
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/113	65/9376	1.27651463580667	GLA	0.247073214851108
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/113	65/9376	1.27651463580667	NR4A1	0.247073214851108
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/113	65/9376	1.27651463580667	PIK3R3	0.247073214851108
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/113	66/9376	1.25717350496112	TNF	0.231564712410209
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/113	154/9376	1.07757728996667	DHFR/NAPRT	0.107209046520574
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/113	68/9376	1.22019781363873	PIK3R3	0.201274288212195
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/113	69/9376	1.20251378735411	FOS	0.186476157722664
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/113	70/9376	1.18533501896334	GSTP1	0.171899261390103
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/113	70/9376	1.18533501896334	PIK3R3	0.171899261390103
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/113	71/9376	1.16864015954132	PIK3R3	0.157536436683217
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/113	250/9376	0.995681415929204	GLA/NEU1/CD63	-0.00764399120251549
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/113	73/9376	1.13662262092375	GSTP1	0.129426009158045
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/113	73/9376	1.13662262092375	RAN	0.129426009158045
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/113	75/9376	1.10631268436578	HSPA5	0.102093929923636
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/113	76/9376	1.09175593851886	UBC	0.0887050880885162
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/113	79/9376	1.050296852246	GSTP1	0.0495829045852003
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/113	80/9376	1.03716814159292	PIK3R3	0.0368737078798156
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/113	82/9376	1.01187135765163	GSTP1	0.0119249072355674
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/113	83/9376	0.999680136475104	UBE2D3	-0.000323277012784263
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/113	83/9376	0.999680136475104	PCBP1	-0.000323277012784263
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/113	178/9376	0.932285969971164	CACYBP/DKK1	-0.100737458121527
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/113	86/9376	0.96480757357481	PIK3R3	-0.0362109240791365
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/113	183/9376	0.906813675709657	RAN/NXT1	-0.140604145104249
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/113	89/9376	0.932285969971164	FN1	-0.0708899990037666
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/113	89/9376	0.932285969971164	SLC38A2	-0.0708899990037666
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/113	90/9376	0.921927236971485	PIK3R3	-0.082196910172255
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/113	97/9376	0.85539640543746	FOS	-0.158111477304414
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/113	98/9376	0.846667870688098	PIK3R3	-0.168526440652049
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/113	98/9376	0.846667870688098	NR4A1	-0.168526440652049
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/113	99/9376	0.838115669974077	PIK3R3	-0.178841234544285
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/113	100/9376	0.829734513274336	TNF	-0.189058097019514
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/113	100/9376	0.829734513274336	TNF	-0.189058097019514
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/113	205/9376	0.809497086121304	HLA-C/PIK3R3	-0.304592520449393
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/113	323/9376	0.770651250719198	DDIT4/SOCS1/PIK3R3	-0.463287310528859
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/113	115/9376	0.721508272412466	DUSP1	-0.331880171057354
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/113	116/9376	0.715288373512359	SLC38A2	-0.340782850713335
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/113	226/9376	0.734278330331271	FOS/PIK3R3	-0.446600981442741
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/113	120/9376	0.691445427728614	PIK3R3	-0.375716237261538
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/113	122/9376	0.680110256782243	PIK3R3	-0.392793697684048
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/113	128/9376	0.648230088495575	NUDT2	-0.442576950171639
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/113	133/9376	0.623860536296493	FOS	-0.482522170694977
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/113	140/9376	0.592667509481669	MAP1LC3B	-0.53631523767096
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/113	143/9376	0.580233925366669	TNF	-0.558666930901622
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/113	144/9376	0.576204523107178	TNF	-0.566029014128143
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/113	149/9376	0.556868800855259	PIK3R3	-0.602204823689575
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/113	149/9376	0.556868800855259	MT-ND2	-0.602204823689575
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/113	155/9376	0.535312589209249	NR4A1	-0.644297984549966
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/113	160/9376	0.51858407079646	HLA-C	-0.678356893087133
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/113	166/9376	0.499840068237552	VDAC2	-0.718095415224358
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/113	193/9376	0.429914255582558	PIK3R3	-0.883843905106404
NA	NA	hsa04382	Cornified envelope formation	1/113	217/9376	0.382366135149464	S100A6	-1.01668394554593
NA	NA	hsa04081	Hormone signaling	1/113	219/9376	0.378874206974583	PIK3R3	-1.02724501519678
Genetic Information Processing	Translation	hsa03010	Ribosome	1/113	222/9376	0.37375428525871	RPL14	-1.04295321741378
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/113	238/9376	0.348627946753923	PIK3R3	-1.1241934511898
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/113	254/9376	0.326667131210369	VDAC2	-1.20157440117306
NA	NA	hsa04519	Cadherin signaling	2/113	404/9376	0.4107596600368	ACTG1/ACTB	-1.33717284797719
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/113	298/9376	0.27843440042763	TNF	-1.39809889001846