ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0051082 unfolded protein binding 16/149 121/18639 0.132231404958678 16.5413500471463 2.13820345751795e-15 1.0006792181184e-12 GO:0031625 ubiquitin protein ligase binding 19/149 302/18639 0.0629139072847682 7.87014978443486 3.96497634101323e-12 9.27804463797095e-10 GO:0044389 ubiquitin-like protein ligase binding 19/149 322/18639 0.0590062111801242 7.38132060527742 1.21595443740329e-11 1.89688892234913e-09 GO:0044183 protein folding chaperone 11/149 75/18639 0.146666666666667 18.3471140939597 1.85399616423486e-11 2.16917551215479e-09 GO:0031072 heat shock protein binding 13/149 131/18639 0.099236641221374 12.4139044008402 4.14815563327567e-11 3.88267367274603e-09 GO:0140662 ATP-dependent protein folding chaperone 8/149 40/18639 0.2 25.0187919463087 8.54961170857829e-10 6.66869713269107e-08 GO:0051087 protein-folding chaperone binding 11/149 134/18639 0.082089552238806 10.2689071421416 1.04083019654182e-08 6.95869331402245e-07 GO:0045296 cadherin binding 13/149 334/18639 0.0389221556886228 4.86892657637745 2.91973096345995e-06 0.000170804261362407 GO:0031386 protein tag activity 4/149 15/18639 0.266666666666667 33.358389261745 4.99921983527395e-06 0.000233963488290821 GO:0141047 molecular tag activity 4/149 15/18639 0.266666666666667 33.358389261745 4.99921983527395e-06 0.000233963488290821 GO:0019207 kinase regulator activity 11/149 287/18639 0.0383275261324042 4.79454201061665 2.00618810960933e-05 0.000853541850270153 GO:0003725 double-stranded RNA binding 6/149 75/18639 0.08 10.0075167785235 3.01650707553201e-05 0.00112049875080865 GO:0016887 ATP hydrolysis activity 13/149 417/18639 0.0311750599520384 3.89981169426875 3.11249653002403e-05 0.00112049875080865 GO:0004860 protein kinase inhibitor activity 6/149 84/18639 0.0714285714285714 8.9352828379674 5.7406649381438e-05 0.00174481143453715 GO:0030957 Tat protein binding 3/149 10/18639 0.3 37.5281879194631 5.76570450183621e-05 0.00174481143453715 GO:0023026 MHC class II protein complex binding 4/149 27/18639 0.148148148148148 18.5324384787472 5.96516729756291e-05 0.00174481143453715 GO:0097718 disordered domain specific binding 4/149 28/18639 0.142857142857143 17.8705656759348 6.91626093148507e-05 0.00190400595055001 GO:0019210 kinase inhibitor activity 6/149 90/18639 0.0666666666666667 8.33959731543624 8.4543593603692e-05 0.00219813343369599 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 11/149 349/18639 0.0315186246418338 3.9427895617392 0.000117168056694433 0.00288603423857868 GO:0140416 transcription regulator inhibitor activity 4/149 33/18639 0.121212121212121 15.1629042098841 0.000133999160708891 0.00313558036058805 GO:0098847 sequence-specific single stranded DNA binding 3/149 14/18639 0.214285714285714 26.8058485139022 0.000170830763715819 0.00380708559138111 GO:0023023 MHC protein complex binding 4/149 37/18639 0.108108108108108 13.523671322329 0.000210975848980445 0.00403227094171248 GO:0004129 cytochrome-c oxidase activity 3/149 15/18639 0.2 25.0187919463087 0.000212288649685956 0.00403227094171248 GO:0140776 protein-containing complex destabilizing activity 3/149 15/18639 0.2 25.0187919463087 0.000212288649685956 0.00403227094171248 GO:0019887 protein kinase regulator activity 9/149 255/18639 0.0352941176470588 4.41508093170154 0.000215399088766692 0.00403227094171248 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/149 16/18639 0.1875 23.4551174496644 0.00025974966877771 0.00467549403799877 GO:0005200 structural constituent of cytoskeleton 6/149 112/18639 0.0535714285714286 6.70146212847555 0.000281345867004245 0.00487666169474024 GO:0051787 misfolded protein binding 3/149 17/18639 0.176470588235294 22.0754046585077 0.000313565595305327 0.00524102495010332 GO:0048156 tau protein binding 4/149 43/18639 0.0930232558139535 11.6366474168878 0.000379840635321789 0.00612984197691715 GO:0003697 single-stranded DNA binding 6/149 121/18639 0.0495867768595041 6.20300626767985 0.000426193873839334 0.00664862443189361 GO:0001784 phosphotyrosine residue binding 4/149 47/18639 0.0851063829787234 10.6462944452378 0.000535564975454594 0.0077641333951182 GO:0008135 translation factor activity, RNA binding 5/149 83/18639 0.0602409638554217 7.5357807067195 0.000536911400741756 0.0077641333951182 GO:0140297 DNA-binding transcription factor binding 12/149 488/18639 0.0245901639344262 3.07608097700517 0.000562192910119117 0.0077641333951182 GO:0180051 translation factor activity 5/149 84/18639 0.0595238095238095 7.4460690316395 0.000567259802726585 0.0077641333951182 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/149 48/18639 0.0833333333333333 10.4244966442953 0.00058065100177166 0.0077641333951182 GO:0070182 DNA polymerase binding 3/149 21/18639 0.142857142857143 17.8705656759348 0.000599087740154894 0.00778814062201362 GO:0060590 ATPase regulator activity 4/149 49/18639 0.0816326530612245 10.2117518148199 0.000628367672788509 0.00794800191527087 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/149 22/18639 0.136363636363636 17.0582672361196 0.00068963080342634 0.0084933477895665 GO:0003743 translation initiation factor activity 4/149 51/18639 0.0784313725490196 9.81129095933675 0.000732032591007972 0.00856478131479327 GO:0030544 Hsp70 protein binding 4/149 51/18639 0.0784313725490196 9.81129095933675 0.000732032591007972 0.00856478131479327 GO:0140104 molecular carrier activity 8/149 249/18639 0.0321285140562249 4.01908304358373 0.000895181005344734 0.0102181636707643 GO:0005525 GTP binding 10/149 378/18639 0.0264550264550265 3.309364014062 0.000940214723613458 0.0104766783488357 GO:0045309 protein phosphorylated amino acid binding 4/149 59/18639 0.0677966101694915 8.48094642247753 0.00126896570366204 0.0130746234432679 GO:0070063 RNA polymerase binding 4/149 59/18639 0.0677966101694915 8.48094642247753 0.00126896570366204 0.0130746234432679 GO:0001671 ATPase activator activity 3/149 27/18639 0.111111111111111 13.8993288590604 0.00127210062602762 0.0130746234432679 GO:0003714 transcription corepressor activity 7/149 204/18639 0.0343137254901961 4.29243979470983 0.00128511256066308 0.0130746234432679 GO:0019001 guanyl nucleotide binding 10/149 400/18639 0.025 3.12734899328859 0.00143655485164937 0.0140064098035814 GO:0032561 guanyl ribonucleotide binding 10/149 400/18639 0.025 3.12734899328859 0.00143655485164937 0.0140064098035814 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/149 68/18639 0.0588235294117647 7.35846821950257 0.00214818200496653 0.0205173301698844 GO:0009055 electron transfer activity 5/149 116/18639 0.0431034482758621 5.39198102291136 0.00240385818810501 0.0225001126406629 GO:0098505 G-rich strand telomeric DNA binding 2/149 10/18639 0.2 25.0187919463087 0.00273880413667214 0.0251325556071091 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/149 11/18639 0.181818181818182 22.7443563148261 0.00332991310712974 0.0298245498986016 GO:0003724 RNA helicase activity 4/149 77/18639 0.051948051948052 6.49838751852175 0.00337756654834591 0.0298245498986016 GO:0008186 ATP-dependent activity, acting on RNA 4/149 79/18639 0.0506329113924051 6.33387137881234 0.00370425971936183 0.0315198827029334 GO:0046332 SMAD binding 4/149 79/18639 0.0506329113924051 6.33387137881234 0.00370425971936183 0.0315198827029334 GO:0005049 nuclear export signal receptor activity 2/149 12/18639 0.166666666666667 20.8489932885906 0.00397500186444826 0.0326368574133647 GO:0043047 single-stranded telomeric DNA binding 2/149 12/18639 0.166666666666667 20.8489932885906 0.00397500186444826 0.0326368574133647 GO:0140597 protein carrier chaperone 6/149 188/18639 0.0319148936170213 3.99236041696416 0.0040600373982723 0.0327603017653696 GO:0035198 miRNA binding 3/149 42/18639 0.0714285714285714 8.9352828379674 0.00457485958763092 0.0362887167290046 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/149 13/18639 0.153846153846154 19.2452245740836 0.00467318135376707 0.0364508145593831 GO:0043176 amine binding 2/149 14/18639 0.142857142857143 17.8705656759348 0.00542357311877562 0.0409392293481772 GO:0044548 S100 protein binding 2/149 14/18639 0.142857142857143 17.8705656759348 0.00542357311877562 0.0409392293481772 GO:0140097 catalytic activity, acting on DNA 8/149 336/18639 0.0238095238095238 2.9784276126558 0.00568604516411299 0.0422391926476965 GO:0030291 protein serine/threonine kinase inhibitor activity 3/149 46/18639 0.0652173913043478 8.15830172162241 0.00591046058265708 0.0432202430106799 GO:0004857 enzyme inhibitor activity 9/149 416/18639 0.0216346153846154 2.70635970573051 0.00633160154572425 0.0455875311292146 GO:0003712 transcription coregulator activity 10/149 495/18639 0.0202020202020202 2.52715070164735 0.00652506050989247 0.0461486175422201 GO:0051219 phosphoprotein binding 4/149 93/18639 0.043010752688172 5.38038536479758 0.00660674652848022 0.0461486175422201 GO:0022858 alanine transmembrane transporter activity 2/149 16/18639 0.125 15.636744966443 0.00707753197982405 0.0477503089660321 GO:0000510 H3-H4 histone complex chaperone activity 5/149 151/18639 0.033112582781457 4.14218409707098 0.00734810797078159 0.0477503089660321 GO:0140584 chromatin extrusion motor activity 5/149 151/18639 0.033112582781457 4.14218409707098 0.00734810797078159 0.0477503089660321 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 5/149 151/18639 0.033112582781457 4.14218409707098 0.00734810797078159 0.0477503089660321 GO:0140849 ATP-dependent H2AZ histone chaperone activity 5/149 151/18639 0.033112582781457 4.14218409707098 0.00734810797078159 0.0477503089660321 GO:0015616 DNA translocase activity 5/149 152/18639 0.0328947368421053 4.11493288590604 0.00755026252881703 0.0477503089660321 GO:0140674 ATP-dependent histone chaperone activity 5/149 152/18639 0.0328947368421053 4.11493288590604 0.00755026252881703 0.0477503089660321 GO:0061775 cohesin loader activity 5/149 153/18639 0.0326797385620915 4.08803789972365 0.00775626353201383 0.0483990844397663 GO:0140658 ATP-dependent chromatin remodeler activity 5/149 158/18639 0.0316455696202532 3.95866961175771 0.00884521849820482 0.0544679244363139 GO:0003689 DNA clamp loader activity 5/149 160/18639 0.03125 3.90918624161074 0.00930896957687086 0.0565791917139683 GO:0097001 ceramide binding 2/149 19/18639 0.105263157894737 13.1677852348993 0.00992869813969871 0.0595721888381923 GO:0140713 histone chaperone activity 5/149 164/18639 0.0304878048780488 3.81384023571779 0.0102862842490447 0.0609364687158599 GO:0016004 phospholipase activator activity 2/149 20/18639 0.1 12.5093959731544 0.0109744956727003 0.0634081972200464 GO:0043024 ribosomal small subunit binding 2/149 20/18639 0.1 12.5093959731544 0.0109744956727003 0.0634081972200464 GO:0061980 regulatory RNA binding 3/149 58/18639 0.0517241379310345 6.47037722749364 0.0112078767440566 0.0639669062953474 GO:0036002 pre-mRNA binding 3/149 59/18639 0.0508474576271186 6.36070981685815 0.0117403184069349 0.0661984218607895 GO:0140517 protein-RNA adaptor activity 2/149 22/18639 0.0909090909090909 11.3721781574131 0.0132043451833962 0.0735670660217787 GO:0043021 ribonucleoprotein complex binding 5/149 177/18639 0.0282485875706215 3.53372767603231 0.0139443792091351 0.0767761114102968 GO:0043274 phospholipase binding 2/149 23/18639 0.0869565217391304 10.8777356288299 0.014386811667424 0.0773911248316604 GO:0099186 structural constituent of postsynapse 2/149 23/18639 0.0869565217391304 10.8777356288299 0.014386811667424 0.0773911248316604 GO:0022853 active monoatomic ion transmembrane transporter activity 4/149 118/18639 0.0338983050847458 4.24047321123877 0.0149104492407958 0.0792964800533229 GO:0060229 lipase activator activity 2/149 24/18639 0.0833333333333333 10.4244966442953 0.0156132649391716 0.0821012133880035 GO:0015078 proton transmembrane transporter activity 5/149 185/18639 0.027027027027027 3.38091783058226 0.0165835718793401 0.0862345737725685 GO:1990841 promoter-specific chromatin binding 3/149 68/18639 0.0441176470588235 5.51885116462693 0.017184232410462 0.0883760523966615 GO:0050681 nuclear androgen receptor binding 2/149 26/18639 0.0769230769230769 9.62261228704182 0.0181950653781501 0.0905881978401517 GO:0050750 low-density lipoprotein particle receptor binding 2/149 26/18639 0.0769230769230769 9.62261228704182 0.0181950653781501 0.0905881978401517 GO:0070412 R-SMAD binding 2/149 26/18639 0.0769230769230769 9.62261228704182 0.0181950653781501 0.0905881978401517 GO:0003730 mRNA 3'-UTR binding 6/149 262/18639 0.0229007633587786 2.86474716942466 0.0189059269596631 0.0926908886154177 GO:0042826 histone deacetylase binding 4/149 127/18639 0.031496062992126 3.93996723563917 0.019013515613419 0.0926908886154177 GO:0005518 collagen binding 3/149 72/18639 0.0416666666666667 5.21224832214765 0.0199851448308788 0.0964231729984669 GO:0046625 sphingolipid binding 2/149 28/18639 0.0714285714285714 8.9352828379674 0.0209437063560343 0.0990066118648895 GO:0051019 mitogen-activated protein kinase binding 2/149 28/18639 0.0714285714285714 8.9352828379674 0.0209437063560343 0.0990066118648895 GO:0003785 actin monomer binding 2/149 29/18639 0.0689655172413793 8.62716963665818 0.0223787445850943 0.104732524658241 GO:0002020 protease binding 4/149 136/18639 0.0294117647058824 3.67923410975128 0.0237538613933352 0.109444525453606 GO:0098918 structural constituent of synapse 2/149 30/18639 0.0666666666666667 8.33959731543624 0.0238532940091192 0.109444525453606 GO:0016922 nuclear receptor binding 4/149 137/18639 0.0291970802919708 3.65237838632244 0.0243208589493793 0.110506427070966 GO:0070325 lipoprotein particle receptor binding 2/149 31/18639 0.0645161290322581 8.07057804719636 0.0253666402468322 0.114149881110745 GO:0008094 ATP-dependent activity, acting on DNA 5/149 210/18639 0.0238095238095238 2.9784276126558 0.0269080179170159 0.118761987449499 GO:0140142 nucleocytoplasmic carrier activity 2/149 32/18639 0.0625 7.81837248322148 0.026918077678272 0.118761987449499 GO:0001618 virus receptor activity 3/149 81/18639 0.037037037037037 4.6331096196868 0.0271528475578984 0.118761987449499 GO:0140272 exogenous protein binding 3/149 82/18639 0.0365853658536585 4.57660828286135 0.0280232025062405 0.121433877527042 GO:0071889 14-3-3 protein binding 2/149 33/18639 0.0606060606060606 7.58145210494204 0.0285069093519227 0.122396638318347 GO:0016831 carboxy-lyase activity 2/149 34/18639 0.0588235294117647 7.35846821950257 0.0301324468927518 0.128199864961889 GO:0016209 antioxidant activity 3/149 86/18639 0.0348837209302326 4.36374278133292 0.0316517915134183 0.132853543503733 GO:0061631 ubiquitin conjugating enzyme activity 2/149 35/18639 0.0571428571428571 7.14822627037392 0.0317940104111497 0.132853543503733 GO:0003727 single-stranded RNA binding 3/149 89/18639 0.0337078651685393 4.21665032802956 0.0345270044325896 0.142996797119044 GO:0004386 helicase activity 4/149 155/18639 0.0258064516129032 3.22823121887855 0.0359385345055045 0.147537141654176 GO:0042162 telomeric DNA binding 2/149 38/18639 0.0526315789473684 6.58389261744966 0.0369881833296472 0.150525824332825 GO:0001530 lipopolysaccharide binding 2/149 41/18639 0.0487804878048781 6.10214437714847 0.0424829098578412 0.168491540792116 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/149 41/18639 0.0487804878048781 6.10214437714847 0.0424829098578412 0.168491540792116 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/149 41/18639 0.0487804878048781 6.10214437714847 0.0424829098578412 0.168491540792116 GO:0015399 primary active transmembrane transporter activity 4/149 166/18639 0.0240963855421687 3.0143122826878 0.0443741313774529 0.171645042890848 GO:0004520 DNA endonuclease activity 2/149 42/18639 0.0476190476190476 5.9568552253116 0.0443783123713518 0.171645042890848 GO:0019894 kinesin binding 2/149 42/18639 0.0476190476190476 5.9568552253116 0.0443783123713518 0.171645042890848 GO:0005201 extracellular matrix structural constituent 4/149 168/18639 0.0238095238095238 2.9784276126558 0.0460174074385748 0.176183343100656 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/149 43/18639 0.0465116279069767 5.81832370844389 0.0463045965841468 0.176183343100656 GO:0001046 core promoter sequence-specific DNA binding 2/149 44/18639 0.0454545454545455 5.68608907870653 0.0482611550222131 0.182146939922546 GO:0004722 protein serine/threonine phosphatase activity 3/149 103/18639 0.029126213592233 3.64351339023913 0.0496539984585263 0.183717011768369 GO:0003924 GTPase activity 6/149 331/18639 0.0181268882175227 2.26756422474097 0.05016180563866 0.183717011768369 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/149 45/18639 0.0444444444444444 5.55973154362416 0.0502473878340838 0.183717011768369 GO:0042605 peptide antigen binding 2/149 45/18639 0.0444444444444444 5.55973154362416 0.0502473878340838 0.183717011768369 GO:0140693 molecular condensate scaffold activity 2/149 48/18639 0.0416666666666667 5.21224832214765 0.0563782466261897 0.204535034271758 GO:0035254 glutamate receptor binding 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.210518380898075 GO:0043022 ribosome binding 3/149 112/18639 0.0267857142857143 3.35073106423778 0.0608153871181836 0.217264131078702 GO:0016830 carbon-carbon lyase activity 2/149 51/18639 0.0392156862745098 4.90564547966838 0.0627552948961944 0.222496045541053 GO:0140313 molecular sequestering activity 2/149 55/18639 0.0363636363636364 4.54887126296522 0.0716151281585522 0.25199909758047 GO:0046982 protein heterodimerization activity 6/149 369/18639 0.016260162601626 2.03404812571616 0.0761390339404464 0.257876854570886 GO:0004601 peroxidase activity 2/149 57/18639 0.0350877192982456 4.38926174496644 0.0761884911147715 0.257876854570886 GO:0016504 peptidase activator activity 2/149 57/18639 0.0350877192982456 4.38926174496644 0.0761884911147715 0.257876854570886 GO:0005522 profilin binding 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.257876854570886 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.257876854570886 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.257876854570886 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.257876854570886 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 2/149 59/18639 0.0338983050847458 4.24047321123877 0.0808519960768711 0.267278349125019 GO:0004519 endonuclease activity 3/149 127/18639 0.0236220472440945 2.95497542672938 0.081751831187103 0.267278349125019 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 3/149 128/18639 0.0234375 2.93188968120805 0.0832456754876556 0.267278349125019 GO:0008199 ferric iron binding 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.267278349125019 GO:0008432 JUN kinase binding 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.267278349125019 GO:0015173 aromatic amino acid transmembrane transporter activity 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.267278349125019 GO:0042608 T cell receptor binding 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.267278349125019 GO:0050998 nitric-oxide synthase binding 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.267278349125019 GO:0016798 hydrolase activity, acting on glycosyl bonds 3/149 130/18639 0.0230769230769231 2.88678368611255 0.0862684966772045 0.270964137214307 GO:0015179 L-amino acid transmembrane transporter activity 2/149 62/18639 0.032258064516129 4.03528902359818 0.0880075805066605 0.273784624883306 GO:0005507 copper ion binding 2/149 63/18639 0.0317460317460317 3.9712368168744 0.0904335942152764 0.273784624883306 GO:0140098 catalytic activity, acting on RNA 6/149 387/18639 0.0155038759689922 1.93944123614796 0.0906860135712292 0.273784624883306 GO:0003720 telomerase activity 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.273784624883306 GO:0015166 polyol transmembrane transporter activity 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.273784624883306 GO:0035259 nuclear glucocorticoid receptor binding 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.273784624883306 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.273784624883306 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.273784624883306 GO:0004536 DNA nuclease activity 2/149 64/18639 0.03125 3.90918624161074 0.0928792294244894 0.275110628928234 GO:0019843 rRNA binding 2/149 65/18639 0.0307692307692308 3.84904491481673 0.0953440226058555 0.279662446322028 GO:0044325 transmembrane transporter binding 3/149 136/18639 0.0220588235294118 2.75942558231346 0.0956110927596677 0.279662446322028 GO:0003964 RNA-directed DNA polymerase activity 1/149 13/18639 0.0769230769230769 9.62261228704182 0.0991109990230177 0.281114833592559 GO:0005542 folic acid binding 1/149 13/18639 0.0769230769230769 9.62261228704182 0.0991109990230177 0.281114833592559 GO:0008035 high-density lipoprotein particle binding 1/149 13/18639 0.0769230769230769 9.62261228704182 0.0991109990230177 0.281114833592559 GO:0019104 DNA N-glycosylase activity 1/149 13/18639 0.0769230769230769 9.62261228704182 0.0991109990230177 0.281114833592559 GO:0039706 co-receptor binding 1/149 13/18639 0.0769230769230769 9.62261228704182 0.0991109990230177 0.281114833592559 GO:0032036 myosin heavy chain binding 1/149 14/18639 0.0714285714285714 8.9352828379674 0.106317724092575 0.297944280690569 GO:1990825 sequence-specific mRNA binding 1/149 14/18639 0.0714285714285714 8.9352828379674 0.106317724092575 0.297944280690569 GO:0019903 protein phosphatase binding 3/149 144/18639 0.0208333333333333 2.60612416107383 0.108678033629561 0.302745950825205 GO:0000774 adenyl-nucleotide exchange factor activity 1/149 15/18639 0.0666666666666667 8.33959731543624 0.113467182299834 0.308736286722805 GO:0005523 tropomyosin binding 1/149 15/18639 0.0666666666666667 8.33959731543624 0.113467182299834 0.308736286722805 GO:0015250 water channel activity 1/149 15/18639 0.0666666666666667 8.33959731543624 0.113467182299834 0.308736286722805 GO:0017081 chloride channel regulator activity 1/149 15/18639 0.0666666666666667 8.33959731543624 0.113467182299834 0.308736286722805 GO:0003688 DNA replication origin binding 1/149 16/18639 0.0625 7.81837248322148 0.120559825654502 0.317477111809024 GO:0005159 insulin-like growth factor receptor binding 1/149 16/18639 0.0625 7.81837248322148 0.120559825654502 0.317477111809024 GO:0008142 oxysterol binding 1/149 16/18639 0.0625 7.81837248322148 0.120559825654502 0.317477111809024 GO:0043023 ribosomal large subunit binding 1/149 16/18639 0.0625 7.81837248322148 0.120559825654502 0.317477111809024 GO:0005092 GDP-dissociation inhibitor activity 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.317477111809024 GO:0008429 phosphatidylethanolamine binding 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.317477111809024 GO:0016018 cyclosporin A binding 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.317477111809024 GO:0070402 NADPH binding 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.317477111809024 GO:1990226 histone methyltransferase binding 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.317477111809024 GO:0048306 calcium-dependent protein binding 2/149 80/18639 0.025 3.12734899328859 0.134317685331925 0.317477111809024 GO:0000900 mRNA regulatory element binding translation repressor activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0003746 translation elongation factor activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0005372 water transmembrane transporter activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0008308 voltage-gated monoatomic anion channel activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0015172 acidic amino acid transmembrane transporter activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0017128 phospholipid scramblase activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0034185 apolipoprotein binding 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0070064 proline-rich region binding 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.317477111809024 GO:0033218 amide binding 4/149 247/18639 0.0161943319838057 2.02581311306144 0.136338068737731 0.317477111809024 GO:0015101 organic cation transmembrane transporter activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:0033192 calmodulin-dependent protein phosphatase activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:0140791 histone H2AXS140 phosphatase activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/149 81/18639 0.0246913580246914 3.08873974645787 0.137030719199622 0.317477111809024 GO:0005178 integrin binding 3/149 161/18639 0.0186335403726708 2.33094334903497 0.138535943340192 0.31750371131425 GO:0042277 peptide binding 4/149 249/18639 0.0160642570281124 2.00954152179187 0.139201829934556 0.31750371131425 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/149 82/18639 0.024390243902439 3.05107218857423 0.139755907116956 0.31750371131425 GO:0033549 MAP kinase phosphatase activity 2/149 82/18639 0.024390243902439 3.05107218857423 0.139755907116956 0.31750371131425 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/149 83/18639 0.0240963855421687 3.0143122826878 0.142492885132484 0.322157827256052 GO:0017018 myosin phosphatase activity 2/149 84/18639 0.0238095238095238 2.9784276126558 0.145241294264428 0.325229309644747 GO:0051117 ATPase binding 2/149 84/18639 0.0238095238095238 2.9784276126558 0.145241294264428 0.325229309644747 GO:0000339 RNA cap binding 1/149 20/18639 0.05 6.25469798657718 0.148371167291522 0.329088655414372 GO:0042288 MHC class I protein binding 1/149 20/18639 0.05 6.25469798657718 0.148371167291522 0.329088655414372 GO:0003713 transcription coactivator activity 4/149 256/18639 0.015625 1.95459312080537 0.149413062899416 0.329836384136447 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.334687705715912 GO:0001846 opsonin binding 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.334687705715912 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.334687705715912 GO:0035613 RNA stem-loop binding 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.334687705715912 GO:0072542 protein phosphatase activator activity 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.334687705715912 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 2/149 89/18639 0.0224719101123595 2.81110021868637 0.159142583264285 0.340085520400389 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 2/149 89/18639 0.0224719101123595 2.81110021868637 0.159142583264285 0.340085520400389 GO:0061133 endopeptidase activator activity 1/149 22/18639 0.0454545454545455 5.68608907870653 0.161947443380335 0.342957836925188 GO:0140793 histone H2AXY142 phosphatase activity 2/149 90/18639 0.0222222222222222 2.77986577181208 0.161952311881339 0.342957836925188 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/149 91/18639 0.021978021978022 2.74931779629766 0.164771093317809 0.346202368693993 GO:0004721 phosphoprotein phosphatase activity 3/149 175/18639 0.0171428571428571 2.14446788111218 0.164963949185386 0.346202368693993 GO:0004602 glutathione peroxidase activity 1/149 23/18639 0.0434782608695652 5.43886781441494 0.168654744821831 0.347711103861749 GO:0005283 amino acid:sodium symporter activity 1/149 23/18639 0.0434782608695652 5.43886781441494 0.168654744821831 0.347711103861749 GO:0016849 phosphorus-oxygen lyase activity 1/149 23/18639 0.0434782608695652 5.43886781441494 0.168654744821831 0.347711103861749 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/149 23/18639 0.0434782608695652 5.43886781441494 0.168654744821831 0.347711103861749 GO:0016853 isomerase activity 3/149 180/18639 0.0166666666666667 2.08489932885906 0.174745047724754 0.356715139101564 GO:0019957 C-C chemokine binding 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.356715139101564 GO:0035035 histone acetyltransferase binding 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.356715139101564 GO:0001848 complement binding 1/149 25/18639 0.04 5.00375838926174 0.181909796631402 0.366955969066794 GO:0019211 phosphatase activator activity 1/149 25/18639 0.04 5.00375838926174 0.181909796631402 0.366955969066794 GO:0004725 protein tyrosine phosphatase activity 2/149 98/18639 0.0204081632653061 2.55293795370497 0.184729623756658 0.370582036103181 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.370582036103181 GO:0008143 poly(A) binding 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.370582036103181 GO:0008198 ferrous iron binding 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.370582036103181 GO:0043548 phosphatidylinositol 3-kinase binding 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.370582036103181 GO:0052742 phosphatidylinositol kinase activity 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.370582036103181 GO:0019902 phosphatase binding 3/149 190/18639 0.0157894736842105 1.9751677852349 0.194772657995168 0.372403654254591 GO:0004364 glutathione transferase activity 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.372403654254591 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.372403654254591 GO:0008266 poly(U) RNA binding 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.372403654254591 GO:0015252 proton channel activity 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.372403654254591 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.372403654254591 GO:0035255 ionotropic glutamate receptor binding 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.372403654254591 GO:0015171 amino acid transmembrane transporter activity 2/149 102/18639 0.0196078431372549 2.45282273983419 0.196286468320984 0.373423037293579 GO:0019789 SUMO transferase activity 1/149 28/18639 0.0357142857142857 4.4676414189837 0.201399763660325 0.381599552198511 GO:0005416 amino acid:monoatomic cation symporter activity 1/149 29/18639 0.0344827586206897 4.31358481832909 0.207793371484441 0.3905513970069 GO:0051861 glycolipid binding 1/149 29/18639 0.0344827586206897 4.31358481832909 0.207793371484441 0.3905513970069 GO:0008187 poly-pyrimidine tract binding 1/149 30/18639 0.0333333333333333 4.16979865771812 0.214136132776693 0.394875580762582 GO:0031210 phosphatidylcholine binding 1/149 30/18639 0.0333333333333333 4.16979865771812 0.214136132776693 0.394875580762582 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/149 30/18639 0.0333333333333333 4.16979865771812 0.214136132776693 0.394875580762582 GO:0048019 receptor antagonist activity 1/149 30/18639 0.0333333333333333 4.16979865771812 0.214136132776693 0.394875580762582 GO:0001664 G protein-coupled receptor binding 4/149 297/18639 0.0134680134680135 1.68476713443156 0.214312815200205 0.394875580762582 GO:0016829 lyase activity 3/149 200/18639 0.015 1.87640939597315 0.215336157874388 0.395205183863582 GO:0005164 tumor necrosis factor receptor binding 1/149 31/18639 0.032258064516129 4.03528902359818 0.220428449194355 0.40297075868343 GO:0031369 translation initiation factor binding 1/149 32/18639 0.03125 3.90918624161074 0.226670719243261 0.404892735136818 GO:0043425 bHLH transcription factor binding 1/149 32/18639 0.03125 3.90918624161074 0.226670719243261 0.404892735136818 GO:0051059 NF-kappaB binding 1/149 32/18639 0.03125 3.90918624161074 0.226670719243261 0.404892735136818 GO:0070717 poly-purine tract binding 1/149 32/18639 0.03125 3.90918624161074 0.226670719243261 0.404892735136818 GO:0071813 lipoprotein particle binding 1/149 32/18639 0.03125 3.90918624161074 0.226670719243261 0.404892735136818 GO:0071814 protein-lipid complex binding 1/149 32/18639 0.03125 3.90918624161074 0.226670719243261 0.404892735136818 GO:0019956 chemokine binding 1/149 33/18639 0.0303030303030303 3.79072605247102 0.232863338302365 0.410799881448419 GO:0140311 protein sequestering activity 1/149 33/18639 0.0303030303030303 3.79072605247102 0.232863338302365 0.410799881448419 GO:0004518 nuclease activity 3/149 209/18639 0.0143540669856459 1.79560707748627 0.234219900443925 0.410799881448419 GO:0035401 histone H3Y41 kinase activity 2/149 115/18639 0.0173913043478261 2.17554712576598 0.23436659903147 0.410799881448419 GO:0140801 histone H2AXY142 kinase activity 2/149 115/18639 0.0173913043478261 2.17554712576598 0.23436659903147 0.410799881448419 GO:0008175 tRNA methyltransferase activity 1/149 34/18639 0.0294117647058824 3.67923410975128 0.239006698648111 0.417369906594463 GO:1990782 protein tyrosine kinase binding 2/149 117/18639 0.0170940170940171 2.13835828600929 0.240271993930863 0.418019677173398 GO:0051020 GTPase binding 4/149 315/18639 0.0126984126984127 1.58849472674976 0.244976400090339 0.420173467677617 GO:0005154 epidermal growth factor receptor binding 1/149 35/18639 0.0285714285714286 3.57411313518696 0.24510118947861 0.420173467677617 GO:0005343 organic acid:sodium symporter activity 1/149 35/18639 0.0285714285714286 3.57411313518696 0.24510118947861 0.420173467677617 GO:0034061 DNA polymerase activity 1/149 35/18639 0.0285714285714286 3.57411313518696 0.24510118947861 0.420173467677617 GO:0000993 RNA polymerase II complex binding 1/149 36/18639 0.0277777777777778 3.4748322147651 0.251147196937634 0.422794561751126 GO:0045505 dynein intermediate chain binding 1/149 36/18639 0.0277777777777778 3.4748322147651 0.251147196937634 0.422794561751126 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/149 36/18639 0.0277777777777778 3.4748322147651 0.251147196937634 0.422794561751126 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/149 36/18639 0.0277777777777778 3.4748322147651 0.251147196937634 0.422794561751126 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/149 36/18639 0.0277777777777778 3.4748322147651 0.251147196937634 0.422794561751126 GO:0022829 wide pore channel activity 1/149 37/18639 0.027027027027027 3.38091783058226 0.257145104138424 0.429799674059937 GO:0043394 proteoglycan binding 1/149 37/18639 0.027027027027027 3.38091783058226 0.257145104138424 0.429799674059937 GO:0042887 amide transmembrane transporter activity 1/149 38/18639 0.0263157894736842 3.29194630872483 0.26309529118731 0.438180057920502 GO:0000217 DNA secondary structure binding 1/149 39/18639 0.0256410256410256 3.20753742901394 0.268998135207152 0.44327861717235 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/149 39/18639 0.0256410256410256 3.20753742901394 0.268998135207152 0.44327861717235 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/149 39/18639 0.0256410256410256 3.20753742901394 0.268998135207152 0.44327861717235 GO:0031490 chromatin DNA binding 2/149 128/18639 0.015625 1.95459312080537 0.272836954733694 0.446637766835976 GO:0015144 carbohydrate transmembrane transporter activity 1/149 40/18639 0.025 3.12734899328859 0.2748540103606 0.446637766835976 GO:0030331 nuclear estrogen receptor binding 1/149 40/18639 0.025 3.12734899328859 0.2748540103606 0.446637766835976 GO:0050997 quaternary ammonium group binding 1/149 40/18639 0.025 3.12734899328859 0.2748540103606 0.446637766835976 GO:0005085 guanyl-nucleotide exchange factor activity 3/149 230/18639 0.0130434782608696 1.63166034432448 0.279276531548639 0.446770131716474 GO:0001727 lipid kinase activity 1/149 41/18639 0.024390243902439 3.05107218857423 0.28066328787317 0.446770131716474 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/149 41/18639 0.024390243902439 3.05107218857423 0.28066328787317 0.446770131716474 GO:0017080 sodium channel regulator activity 1/149 41/18639 0.024390243902439 3.05107218857423 0.28066328787317 0.446770131716474 GO:0042169 SH2 domain binding 1/149 41/18639 0.024390243902439 3.05107218857423 0.28066328787317 0.446770131716474 GO:0042287 MHC protein binding 1/149 41/18639 0.024390243902439 3.05107218857423 0.28066328787317 0.446770131716474 GO:0008307 structural constituent of muscle 1/149 42/18639 0.0238095238095238 2.9784276126558 0.286426336056141 0.448319482522655 GO:0016859 cis-trans isomerase activity 1/149 42/18639 0.0238095238095238 2.9784276126558 0.286426336056141 0.448319482522655 GO:0031492 nucleosomal DNA binding 1/149 42/18639 0.0238095238095238 2.9784276126558 0.286426336056141 0.448319482522655 GO:0043175 RNA polymerase core enzyme binding 1/149 42/18639 0.0238095238095238 2.9784276126558 0.286426336056141 0.448319482522655 GO:0051879 Hsp90 protein binding 1/149 42/18639 0.0238095238095238 2.9784276126558 0.286426336056141 0.448319482522655 GO:0008200 ion channel inhibitor activity 1/149 43/18639 0.0232558139534884 2.90916185422194 0.292143520329283 0.455743891713682 GO:0140789 histone phosphatase activity 2/149 136/18639 0.0147058823529412 1.83961705487564 0.296507101926857 0.458478668151025 GO:0003954 NADH dehydrogenase activity 1/149 44/18639 0.0227272727272727 2.84304453935326 0.297815203243401 0.458478668151025 GO:0016248 channel inhibitor activity 1/149 44/18639 0.0227272727272727 2.84304453935326 0.297815203243401 0.458478668151025 GO:0030547 signaling receptor inhibitor activity 1/149 44/18639 0.0227272727272727 2.84304453935326 0.297815203243401 0.458478668151025 GO:0022804 active transmembrane transporter activity 5/149 457/18639 0.0109409190371991 1.36864288546547 0.302638878073198 0.462575688688161 GO:0140303 intramembrane lipid transporter activity 1/149 45/18639 0.0222222222222222 2.77986577181208 0.303441744502704 0.462575688688161 GO:0141110 transporter inhibitor activity 1/149 45/18639 0.0222222222222222 2.77986577181208 0.303441744502704 0.462575688688161 GO:0005539 glycosaminoglycan binding 3/149 242/18639 0.012396694214876 1.55075156691996 0.305406213237448 0.464058791542615 GO:0004713 protein tyrosine kinase activity 2/149 140/18639 0.0142857142857143 1.78705656759348 0.308305318811682 0.466947861501188 GO:0141003 histone H2AX kinase activity 4/149 354/18639 0.0112994350282486 1.41349107041292 0.314170620306348 0.471841240160624 GO:0020037 heme binding 2/149 142/18639 0.0140845070422535 1.7618867567823 0.314190737167783 0.471841240160624 GO:0005504 fatty acid binding 1/149 47/18639 0.0212765957446809 2.66157361130944 0.314560826773749 0.471841240160624 GO:0140996 histone H3 kinase activity 4/149 357/18639 0.0112044817927171 1.40161299419096 0.31959001077558 0.477023268276491 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/149 48/18639 0.0208333333333333 2.60612416107383 0.320054073159868 0.477023268276491 GO:0035173 histone kinase activity 4/149 360/18639 0.0111111111111111 1.38993288590604 0.325017146173508 0.482074935138801 GO:0016763 pentosyltransferase activity 1/149 49/18639 0.0204081632653061 2.55293795370497 0.325503588683464 0.482074935138801 GO:0032813 tumor necrosis factor receptor superfamily binding 1/149 50/18639 0.02 2.50187919463087 0.330909719145334 0.488535484416455 GO:0005080 protein kinase C binding 1/149 52/18639 0.0192307692307692 2.40565307176045 0.341593194528482 0.501146128649935 GO:0030159 signaling receptor complex adaptor activity 1/149 52/18639 0.0192307692307692 2.40565307176045 0.341593194528482 0.501146128649935 GO:0046906 tetrapyrrole binding 2/149 152/18639 0.0131578947368421 1.64597315436242 0.343434676025593 0.50227321368743 GO:0005246 calcium channel regulator activity 1/149 53/18639 0.0188679245283019 2.3602633911612 0.346871217556149 0.503933257221774 GO:0016860 intramolecular oxidoreductase activity 1/149 53/18639 0.0188679245283019 2.3602633911612 0.346871217556149 0.503933257221774 GO:0005506 iron ion binding 2/149 154/18639 0.012987012987013 1.62459687963044 0.349239343144946 0.503933257221774 GO:0003925 G protein activity 1/149 54/18639 0.0185185185185185 2.3165548098434 0.352107211776752 0.503933257221774 GO:0015485 cholesterol binding 1/149 54/18639 0.0185185185185185 2.3165548098434 0.352107211776752 0.503933257221774 GO:0017069 snRNA binding 1/149 54/18639 0.0185185185185185 2.3165548098434 0.352107211776752 0.503933257221774 GO:0050661 NADP binding 1/149 54/18639 0.0185185185185185 2.3165548098434 0.352107211776752 0.503933257221774 GO:0099106 ion channel regulator activity 2/149 160/18639 0.0125 1.5636744966443 0.366547471050493 0.523000659913508 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1/149 58/18639 0.0172413793103448 2.15679240916455 0.372637510160686 0.527608244796339 GO:0016791 phosphatase activity 3/149 273/18639 0.010989010989011 1.37465889814883 0.373091743931543 0.527608244796339 GO:0005126 cytokine receptor binding 3/149 275/18639 0.0109090909090909 1.36466137888957 0.37743363697094 0.527608244796339 GO:1901681 sulfur compound binding 3/149 275/18639 0.0109090909090909 1.36466137888957 0.37743363697094 0.527608244796339 GO:0004879 nuclear receptor activity 1/149 59/18639 0.0169491525423729 2.12023660561938 0.377668294886269 0.527608244796339 GO:0015459 potassium channel regulator activity 1/149 59/18639 0.0169491525423729 2.12023660561938 0.377668294886269 0.527608244796339 GO:0070888 E-box binding 1/149 59/18639 0.0169491525423729 2.12023660561938 0.377668294886269 0.527608244796339 GO:0001098 basal transcription machinery binding 1/149 60/18639 0.0166666666666667 2.08489932885906 0.382659006622649 0.52983554763136 GO:0001099 basal RNA polymerase II transcription machinery binding 1/149 60/18639 0.0166666666666667 2.08489932885906 0.382659006622649 0.52983554763136 GO:0098531 ligand-modulated transcription factor activity 1/149 60/18639 0.0166666666666667 2.08489932885906 0.382659006622649 0.52983554763136 GO:0016874 ligase activity 2/149 167/18639 0.0119760479041916 1.49813125426998 0.386514721498531 0.532788531487924 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/149 61/18639 0.0163934426229508 2.05072065133678 0.387609962433684 0.532788531487924 GO:0030246 carbohydrate binding 3/149 280/18639 0.0107142857142857 1.34029242569511 0.388261449892557 0.532788531487924 GO:0016247 channel regulator activity 2/149 168/18639 0.0119047619047619 1.4892138063279 0.389345465318099 0.532788531487924 GO:0031267 small GTPase binding 3/149 283/18639 0.0106007067137809 1.32608437877961 0.394737428506351 0.537369742967773 GO:0141108 transporter regulator activity 2/149 170/18639 0.0117647058823529 1.47169364390051 0.394989725600243 0.537369742967773 GO:0008201 heparin binding 2/149 172/18639 0.0116279069767442 1.45458092711097 0.400610427680269 0.543436754070626 GO:0003823 antigen binding 2/149 174/18639 0.0114942528735632 1.4378616061097 0.406206889974832 0.549435908983299 GO:0008173 RNA methyltransferase activity 1/149 67/18639 0.0149253731343284 1.86707402584393 0.416498266923881 0.560118358966599 GO:0050840 extracellular matrix binding 1/149 67/18639 0.0149253731343284 1.86707402584393 0.416498266923881 0.560118358966599 GO:0005548 phospholipid transporter activity 1/149 68/18639 0.0147058823529412 1.83961705487564 0.421179602172015 0.56317729661858 GO:0032934 sterol binding 1/149 68/18639 0.0147058823529412 1.83961705487564 0.421179602172015 0.56317729661858 GO:0002039 p53 binding 1/149 69/18639 0.0144927536231884 1.81295593813831 0.425823629918306 0.56615187159593 GO:0008080 N-acetyltransferase activity 1/149 69/18639 0.0144927536231884 1.81295593813831 0.425823629918306 0.56615187159593 GO:0097110 scaffold protein binding 1/149 70/18639 0.0142857142857143 1.78705656759348 0.430430645488697 0.570655926596913 GO:0031406 carboxylic acid binding 2/149 187/18639 0.0106951871657754 1.33790331263683 0.441950342940947 0.58142765830241 GO:0004521 RNA endonuclease activity 1/149 73/18639 0.0136986301369863 1.71361588673347 0.44403253768227 0.58142765830241 GO:0043539 protein serine/threonine kinase activator activity 1/149 73/18639 0.0136986301369863 1.71361588673347 0.44403253768227 0.58142765830241 GO:0046943 carboxylic acid transmembrane transporter activity 2/149 188/18639 0.0106382978723404 1.33078680565472 0.444651733238013 0.58142765830241 GO:0005342 organic acid transmembrane transporter activity 2/149 189/18639 0.0105820105820106 1.3237456056248 0.447345932275247 0.58142765830241 GO:0043177 organic acid binding 2/149 189/18639 0.0105820105820106 1.3237456056248 0.447345932275247 0.58142765830241 GO:0003684 damaged DNA binding 1/149 74/18639 0.0135135135135135 1.69045891529113 0.448494411639253 0.58142765830241 GO:0031491 nucleosome binding 1/149 74/18639 0.0135135135135135 1.69045891529113 0.448494411639253 0.58142765830241 GO:0019003 GDP binding 1/149 75/18639 0.0133333333333333 1.66791946308725 0.452920715580311 0.585543908540292 GO:0017022 myosin binding 1/149 76/18639 0.0131578947368421 1.64597315436242 0.457311731168467 0.589591983985793 GO:0051540 metal cluster binding 1/149 77/18639 0.012987012987013 1.62459687963044 0.461667737851433 0.593572805808986 GO:0015370 solute:sodium symporter activity 1/149 79/18639 0.0126582278481013 1.58346784470308 0.470275831319789 0.601336308900714 GO:0033293 monocarboxylic acid binding 1/149 79/18639 0.0126582278481013 1.58346784470308 0.470275831319789 0.601336308900714 GO:0030971 receptor tyrosine kinase binding 1/149 81/18639 0.0123456790123457 1.54436987322893 0.478747187915123 0.610500501210566 GO:0005516 calmodulin binding 2/149 207/18639 0.00966183574879227 1.20863729209221 0.494552008774711 0.628941141593926 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/149 86/18639 0.0116279069767442 1.45458092711097 0.499341431601769 0.633311083982731 GO:0016651 oxidoreductase activity, acting on NAD(P)H 1/149 88/18639 0.0113636363636364 1.42152226967663 0.507350979444011 0.641730428053506 GO:0072341 modified amino acid binding 1/149 91/18639 0.010989010989011 1.37465889814883 0.519127260460205 0.654855951200474 GO:0043178 alcohol binding 1/149 92/18639 0.0108695652173913 1.35971695360374 0.522990212702572 0.657955428883881 GO:0016410 N-acyltransferase activity 1/149 94/18639 0.0106382978723404 1.33078680565472 0.530623885600989 0.663989247222627 GO:0042562 hormone binding 1/149 94/18639 0.0106382978723404 1.33078680565472 0.530623885600989 0.663989247222627 GO:0019787 ubiquitin-like protein transferase activity 4/149 479/18639 0.00835073068893528 1.04462596853064 0.535315507558059 0.668073753432457 GO:0016407 acetyltransferase activity 1/149 96/18639 0.0104166666666667 1.30306208053691 0.538136202306253 0.669807826274804 GO:0061134 peptidase regulator activity 2/149 226/18639 0.00884955752212389 1.10702619231455 0.541548449870031 0.672267041217969 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/149 229/18639 0.00873362445414847 1.09252366577767 0.548689928310876 0.672585558574699 GO:0030695 GTPase regulator activity 4/149 489/18639 0.0081799591002045 1.02326347428666 0.551697794096373 0.672585558574699 GO:0043130 ubiquitin binding 1/149 100/18639 0.01 1.25093959731544 0.552804402790889 0.672585558574699 GO:0060589 nucleoside-triphosphatase regulator activity 4/149 490/18639 0.00816326530612245 1.02117518148199 0.553319616351804 0.672585558574699 GO:0106310 protein serine kinase activity 3/149 361/18639 0.00831024930747922 1.03956199222889 0.553581790231306 0.672585558574699 GO:0042578 phosphoric ester hydrolase activity 3/149 363/18639 0.00826446280991736 1.03383437794664 0.557336624209787 0.672585558574699 GO:0016755 aminoacyltransferase activity 4/149 496/18639 0.00806451612903226 1.00882225589955 0.562986044735794 0.672585558574699 GO:0005253 monoatomic anion channel activity 1/149 103/18639 0.00970873786407767 1.21450446341304 0.563501029203965 0.672585558574699 GO:0019888 protein phosphatase regulator activity 1/149 107/18639 0.00934579439252336 1.1691024273976 0.57736884773814 0.672585558574699 GO:0005496 steroid binding 1/149 108/18639 0.00925925925925926 1.1582774049217 0.58076686423323 0.672585558574699 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 2/149 243/18639 0.00823045267489712 1.02957991548596 0.580985826006375 0.672585558574699 GO:0004676 3-phosphoinositide-dependent protein kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0004711 ribosomal protein S6 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0035175 histone H3S10 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0035979 histone H2AXS139 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0044022 histone H3S28 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0044023 histone H4S1 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0044024 histone H2AS1 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0044025 histone H2BS14 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0072354 histone H3T3 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0072371 histone H2AS121 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0072518 Rho-dependent protein serine/threonine kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0140823 histone H2BS36 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0140855 histone H3S57 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0140995 histone H2A kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0140997 histone H4 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0140998 histone H2B kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:1990244 histone H2AT120 kinase activity 2/149 245/18639 0.00816326530612245 1.02117518148199 0.585459889602715 0.672585558574699 GO:0004677 DNA-dependent protein kinase activity 2/149 246/18639 0.00813008130081301 1.01702406285808 0.587683774927541 0.672585558574699 GO:0140857 histone H3T45 kinase activity 2/149 246/18639 0.00813008130081301 1.01702406285808 0.587683774927541 0.672585558574699 GO:0035402 histone H3T11 kinase activity 2/149 247/18639 0.00809716599190283 1.01290655653072 0.589898891118073 0.672585558574699 GO:0035403 histone H3T6 kinase activity 2/149 247/18639 0.00809716599190283 1.01290655653072 0.589898891118073 0.672585558574699 GO:0042393 histone binding 2/149 247/18639 0.00809716599190283 1.01290655653072 0.589898891118073 0.672585558574699 GO:1902936 phosphatidylinositol bisphosphate binding 1/149 111/18639 0.00900900900900901 1.12697261019409 0.590798941256535 0.672585558574699 GO:0004679 AMP-activated protein kinase activity 2/149 248/18639 0.00806451612903226 1.00882225589955 0.592105235326445 0.672585558574699 GO:0001221 transcription coregulator binding 1/149 115/18639 0.00869565217391304 1.08777356288299 0.603805035729838 0.684214907316136 GO:0015294 solute:monoatomic cation symporter activity 1/149 116/18639 0.00862068965517241 1.07839620458227 0.606991877107308 0.686164730643044 GO:0019208 phosphatase regulator activity 1/149 117/18639 0.00854700854700855 1.06917914300465 0.610153255410553 0.688076442246118 GO:0032182 ubiquitin-like protein binding 1/149 120/18639 0.00833333333333333 1.04244966442953 0.619486624801082 0.696922452901217 GO:0004540 RNA nuclease activity 1/149 121/18639 0.00826446280991736 1.03383437794664 0.622548155818126 0.698687138903796 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/149 122/18639 0.00819672131147541 1.02536032566839 0.625585218394166 0.700415986144664 GO:0008514 organic anion transmembrane transporter activity 2/149 269/18639 0.00743494423791822 0.930066615104413 0.636413103679679 0.710838502439355 GO:0035591 signaling adaptor activity 1/149 129/18639 0.00775193798449612 0.969720618073982 0.646175665293042 0.720024312755104 GO:0016779 nucleotidyltransferase activity 1/149 136/18639 0.00735294117647059 0.919808527437821 0.665640950202425 0.739952410201271 GO:0030295 protein kinase activator activity 1/149 139/18639 0.00719424460431655 0.899956544831249 0.67365403580669 0.741811973547132 GO:0070851 growth factor receptor binding 1/149 139/18639 0.00719424460431655 0.899956544831249 0.67365403580669 0.741811973547132 GO:0140101 catalytic activity, acting on a tRNA 1/149 139/18639 0.00719424460431655 0.899956544831249 0.67365403580669 0.741811973547132 GO:0140767 enzyme-substrate adaptor activity 1/149 139/18639 0.00719424460431655 0.899956544831249 0.67365403580669 0.741811973547132 GO:0004674 protein serine/threonine kinase activity 3/149 433/18639 0.0069284064665127 0.866701799525706 0.676278191827026 0.742953506514197 GO:0019955 cytokine binding 1/149 144/18639 0.00694444444444444 0.868708053691275 0.686587456478076 0.752512715765198 GO:0003779 actin binding 3/149 443/18639 0.00677200902934537 0.84713742481858 0.691214327972643 0.754491380171158 GO:0015293 symporter activity 1/149 146/18639 0.00684931506849315 0.856807943366737 0.691617098490228 0.754491380171158 GO:0019209 kinase activator activity 1/149 148/18639 0.00675675675675676 0.845229457645565 0.696566557918317 0.758123602571564 GO:0008509 monoatomic anion transmembrane transporter activity 1/149 149/18639 0.00671140939597315 0.839556776721769 0.699011616750731 0.758135253860732 GO:0004842 ubiquitin-protein transferase activity 3/149 449/18639 0.0066815144766147 0.835817102883365 0.699927127325194 0.758135253860732 GO:0019842 vitamin binding 1/149 150/18639 0.00666666666666667 0.833959731543624 0.701437104533541 0.758135253860732 GO:0140375 immune receptor activity 1/149 156/18639 0.00641025641025641 0.801884357253485 0.715587667479651 0.771647530830591 GO:0008083 growth factor activity 1/149 162/18639 0.00617283950617284 0.772184936614467 0.729071844601935 0.784380743157944 GO:0015081 sodium ion transmembrane transporter activity 1/149 164/18639 0.00609756097560976 0.762768047143559 0.733423916066228 0.787253194309621 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/149 167/18639 0.00598802395209581 0.749065627134992 0.739822152816421 0.792303815830858 GO:0030371 translation repressor activity 2/149 329/18639 0.0060790273556231 0.760449603231268 0.742338658349019 0.793183771934569 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 3/149 484/18639 0.00619834710743802 0.775375783459981 0.747080890419223 0.796432475435527 GO:0005244 voltage-gated monoatomic ion channel activity 1/149 173/18639 0.00578034682080925 0.723086472436668 0.752164555529129 0.798820048906852 GO:0001216 DNA-binding transcription activator activity 3/149 491/18639 0.00610997963340122 0.764321546221244 0.75577384218204 0.798820048906852 GO:0003735 structural constituent of ribosome 1/149 175/18639 0.00571428571428571 0.714822627037392 0.756148037747298 0.798820048906852 GO:0022832 voltage-gated channel activity 1/149 175/18639 0.00571428571428571 0.714822627037392 0.756148037747298 0.798820048906852 GO:0005319 lipid transporter activity 1/149 178/18639 0.00561797752808989 0.702775054671593 0.762004319378474 0.802471705911238 GO:0005543 phospholipid binding 3/149 497/18639 0.00603621730382294 0.755094324335273 0.763033993868591 0.802471705911238 GO:0061135 endopeptidase regulator activity 1/149 184/18639 0.00543478260869565 0.679858476801868 0.773301029691355 0.811433203098076 GO:1901981 phosphatidylinositol phosphate binding 1/149 185/18639 0.00540540540540541 0.676183566116452 0.775131327528038 0.811433203098076 GO:0061630 ubiquitin protein ligase activity 2/149 353/18639 0.0056657223796034 0.708747647204213 0.776756570487047 0.811433203098076 GO:0045182 translation regulator activity 2/149 356/18639 0.00561797752808989 0.702775054671593 0.780766117520143 0.81380521826153 GO:0061659 ubiquitin-like protein ligase activity 2/149 372/18639 0.00537634408602151 0.672548170599697 0.80110718724925 0.83315147473922 GO:0008168 methyltransferase activity 1/149 204/18639 0.00490196078431373 0.613205684958547 0.807246932259577 0.837675308863596 GO:0051015 actin filament binding 1/149 209/18639 0.00478468899521531 0.598535692495424 0.814912433134786 0.843425534219419 GO:0015631 tubulin binding 2/149 385/18639 0.00519480519480519 0.649838751852175 0.816392664532899 0.843425534219419 GO:0016741 transferase activity, transferring one-carbon groups 1/149 215/18639 0.00465116279069767 0.581832370844389 0.823712286309852 0.849113105711478 GO:0000287 magnesium ion binding 1/149 230/18639 0.00434782608695652 0.543886781441494 0.843935629497829 0.86804807605491 GO:0005125 cytokine activity 1/149 234/18639 0.00427350427350427 0.534589571502323 0.848927675477078 0.871267877463317 GO:0005216 monoatomic ion channel activity 2/149 448/18639 0.00446428571428571 0.558455177372963 0.87658695037155 0.897686417448327 GO:0016757 glycosyltransferase activity 1/149 267/18639 0.00374531835205993 0.468516703114396 0.884498751294223 0.902796965898021 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 1/149 268/18639 0.00373134328358209 0.466768506460984 0.885435485784597 0.902796965898021 GO:0005096 GTPase activator activity 1/149 271/18639 0.003690036900369 0.46160132742267 0.888200651344716 0.903647619194189 GO:0008017 microtubule binding 1/149 276/18639 0.0036231884057971 0.453238984534578 0.892662700423893 0.906013133757948 GO:0001217 DNA-binding transcription repressor activity 1/149 278/18639 0.00359712230215827 0.449978272415625 0.894397580761052 0.906013133757948 GO:0035091 phosphatidylinositol binding 1/149 284/18639 0.00352112676056338 0.440471689195576 0.899436858834625 0.909149999858757 GO:0015291 secondary active transmembrane transporter activity 1/149 287/18639 0.00348432055749129 0.435867455510605 0.901866181496374 0.90964088995755 GO:0022836 gated channel activity 1/149 318/18639 0.00314465408805031 0.3933772318602 0.923796459660373 0.929756436819472 GO:0005261 monoatomic cation channel activity 1/149 341/18639 0.00293255131964809 0.366844456690744 0.936852281742056 0.940873106985584 GO:0004175 endopeptidase activity 1/149 405/18639 0.00246913580246914 0.308873974645787 0.96261435565914 0.964675628369331 GO:0046873 metal ion transmembrane transporter activity 1/149 450/18639 0.00222222222222222 0.277986577181208 0.974168144604919 0.974168144604919