category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/39	82/9376	17.5909943714822	KLRC3/HSPA1A/KLRC1/HSPA1B/KLRC2/HSPA6	9.75196806500968
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/39	56/9376	17.1721611721612	HSPA1A/HSPA1B/IL18/HSPA6	7.84455623218309
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/39	298/9376	5.64722078816039	IL32/CCL3/CCL3L1/TNFRSF4/TNFRSF18/TNFSF9/IL18	5.26890794985344
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/39	216/9376	6.67806267806268	CCL3/HSPA1A/HSPA1B/CCL3L1/IL18/HSPA6	5.4562414849355
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/39	62/9376	11.6327543424318	HSPA1A/HSPA1B/HSPA6	5.42859910028362
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/39	275/9376	4.37109557109557	MT-CO1/HSPA1A/HSPA1B/NCAM1/HSPA6	3.66696797443356
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/39	174/9376	5.52667256115532	HSPA1A/HSPA1B/HERPUD1/HSPA6	3.89517391096003
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/39	95/9376	7.5919028340081	CCL3/CCL3L1/IL18	4.17339484977506
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/39	100/9376	7.21230769230769	CCL3/CCL3L1/IL18	4.03633171447128
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/39	112/9376	6.43956043956044	HSPA1A/HSPA1B/HSPA6	3.74272404294861
Genetic Information Processing	Translation	hsa03010	Ribosome	4/39	222/9376	4.33171633171633	MRPL18/RPS3A/RPL14/RPL3	3.2467833725569
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/39	133/9376	5.42278773857721	KLRC3/KLRC1/KLRC2	3.31993593508672
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/39	136/9376	5.30316742081448	HSPA1A/HSPA1B/HSPA6	3.26690100225573
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/39	139/9376	5.18871057000553	HSPA1A/HSPA1B/HSPA6	3.21541137122248
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/39	154/9376	4.68331668331668	DHFR/NAPRT/AK5	2.97852413755792
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/39	300/9376	3.20547008547009	HSPA1A/HSPA1B/GADD45B/HSPA6	2.50916266901795
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/39	75/9376	6.41094017094017	GADD45B/IGFBP3	3.04055458043967
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/39	12/9376	20.034188034188	NCAM1	4.26391499556333
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	3/39	204/9376	3.53544494720965	FN1/LUM/DCN	2.36620031603136
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/39	93/9376	5.17011304108078	FN1/GADD45B	2.61191710249738
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/39	15/9376	16.0273504273504	AK5	3.76427361135365
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/39	103/9376	4.66816031864575	CCL3/CCL3L1	2.41919598598518
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/39	105/9376	4.57924297924298	UBC/CCZ1B	2.38361880516908
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	3/39	233/9376	3.0954110267415	FN1/DCN/MYOM2	2.09323066289624
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/39	109/9376	4.41119736532581	CCL3/CCL3L1	2.31507346587179
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/39	238/9376	3.03038138332256	RPS3A/RPL14/RPL3	2.05047645451414
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/39	243/9376	2.96802785691675	HSPA1A/HSPA1B/HSPA6	2.00882410810021
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/39	250/9376	2.88492307692308	HSPA1A/HSPA1B/HSPA6	1.95226004423086
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/39	22/9376	10.9277389277389	AOC1	3.01284831923055
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/39	122/9376	3.94115174443043	SOCS2/IGFBP3	2.11323045990596
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/39	28/9376	8.58608058608059	DHFR	2.59807316970621
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/39	138/9376	3.4842066146414	FN1/IL18	1.89999536013391
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/39	30/9376	8.01367521367521	DHFR	2.48660986465192
NA	NA	hsa04981	Folate transport and metabolism	1/39	31/9376	7.75516956162117	DHFR	2.43467900719265
Human Diseases	Immune disease	hsa05310	Asthma	1/39	32/9376	7.51282051282051	PRG2	2.38501956580127
NA	NA	hsa04518	Integrin signaling	2/39	154/9376	3.12221112221112	FN1/ITGAD	1.71613184419642
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	2/39	157/9376	3.06255103707333	GADD45B/IGFBP3	1.68432883961139
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/39	37/9376	6.4975744975745	IL18	2.16538966596257
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/39	37/9376	6.4975744975745	GADD45B	2.16538966596257
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/39	38/9376	6.32658569500675	NAPRT	2.12631716074797
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/39	39/9376	6.16436554898093	DHFR	2.08862206498953
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/39	42/9376	5.72405372405372	AOC1	1.98298686353856
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/39	44/9376	5.46386946386946	MBD4	1.91807118761509
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/39	45/9376	5.34245014245014	KLRC1	1.88708414299848
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/39	47/9376	5.11511183851609	SOCS2	1.82779416891545
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/39	50/9376	4.80820512820513	AOC1	1.74490542320874
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/39	50/9376	4.80820512820513	IL18	1.74490542320874
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/39	193/9376	2.49129799388867	CCL3/CCL3L1	1.35289801101739
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	2/39	201/9376	2.39214185482842	GADD45B/IGFBP3	1.28941508070468
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/39	59/9376	4.07475010864841	GADD45B	1.53112992964887
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/39	63/9376	3.81603581603582	ERCC5	1.44936546767615
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/39	63/9376	3.81603581603582	GADD45B	1.44936546767615
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/39	66/9376	3.64257964257964	IL18	1.3923213240701
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	2/39	227/9376	2.11815203885688	CCL3/CCL3L1	1.1021513505001
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	2/39	232/9376	2.07250221043325	FN1/ITGAD	1.06902618240014
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/39	71/9376	3.38605994944023	SOCS2	1.30426727903132
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/39	73/9376	3.29329118370214	GADD45B	1.27122780475359
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/39	73/9376	3.29329118370214	GADD45B	1.27122780475359
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/39	76/9376	3.16329284750337	UBC	1.22375618150182
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/39	76/9376	3.16329284750337	GADD45B	1.22375618150182
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/39	77/9376	3.12221112221112	GADD45B	1.20845389914154
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/39	77/9376	3.12221112221112	GADD45B	1.20845389914154
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/39	78/9376	3.08218277449047	FN1	1.19339892431173
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	2/39	253/9376	1.90047633525894	IL18/UBC	0.938378371825541
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/39	83/9376	2.89650911337658	IL18	1.12158004530386
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/39	85/9376	2.82835595776772	AK5	1.09434245096996
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/39	87/9376	2.76333628057766	MT-CO1	1.06788515766661
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/39	87/9376	2.76333628057766	GADD45B	1.06788515766661
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	2/39	268/9376	1.79410639112132	MT-CO1/UBC	0.852410596086291
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/39	89/9376	2.7012388360703	FN1	1.04216583359315
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/39	101/9376	2.38029956841838	FN1	0.901345598388878
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/39	103/9376	2.33408015932288	FN1	0.879841960562917
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/39	105/9376	2.28962148962149	GADD45B	0.858831337251681
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/39	110/9376	2.18554778554779	DCN	0.80832036493243
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/39	128/9376	1.87820512820513	AK5	0.646533905996305
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/39	133/9376	1.80759591285907	GADD45B	0.606216452294071
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/39	137/9376	1.75481938985589	GADD45B	0.575181766340727
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/39	138/9376	1.7421033073207	MT-CO1	0.567582757544866
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/39	138/9376	1.7421033073207	SOCS2	0.567582757544866
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/39	142/9376	1.69302997472012	UBC	0.53779346227051
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/39	144/9376	1.66951566951567	ZFHX3	0.52324893884513
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/39	148/9376	1.62439362439362	GADD45B	0.494822896299136
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/39	150/9376	1.60273504273504	GADD45B	0.480927497042768
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/39	157/9376	1.53127551853667	MT-CO1	0.433852380652139
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/39	158/9376	1.52158390133074	GADD45B	0.427315486311357
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/39	160/9376	1.5025641025641	NCAM1	0.414375896103514
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/39	168/9376	1.43101343101343	SOCS2	0.364314998827837
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/39	169/9376	1.42254589591868	UBC	0.35823864281038
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/39	170/9376	1.41417797888386	GADD45B	0.352200722238523
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/39	173/9376	1.38965466133096	IL18	0.334312394980676
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/39	178/9376	1.35061941803515	NOTUM	0.305220377674402
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/39	181/9376	1.32823346083015	IL18	0.28817780882309
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/39	187/9376	1.28561634443987	IL18	0.254967013043755
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	1/39	196/9376	1.22658294086866	UBC	0.207180161220195
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/39	200/9376	1.20205128205128	IL18	0.186665547374274
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	1/39	203/9376	1.18428697739043	FN1	0.171554151223518
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	1/39	205/9376	1.17273295809881	GADD45B	0.161606214216112
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/39	205/9376	1.17273295809881	MT-CO1	0.161606214216112
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	2/39	480/9376	1.0017094017094	MT-CO1/UBC	0.00248474386971255
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	1/39	227/9376	1.05907601942844	MT-CO1	0.0582306451471415
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	1/39	235/9376	1.02302236770322	MT-CO1	0.0230994332748781
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	1/39	248/9376	0.969396195202647	IL18	-0.0315665929598913
NA	NA	hsa04517	IgSF CAM signaling	1/39	299/9376	0.804047680301861	NCAM1	-0.222550768244469
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/39	308/9376	0.780552780552781	MT-CO1	-0.253083567222633
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	1/39	333/9376	0.721952721952722	FN1	-0.333886424590492
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	1/39	362/9376	0.664116730415073	FN1	-0.421209485497954
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	1/39	368/9376	0.653288740245262	MT-CO1	-0.438522547998539
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	1/39	388/9376	0.619614062913032	MT-CO1	-0.494564621315781