category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/377	174/9376	4.14500442086649	HSP90AA1/DNAJA1/HSP90AB1/HSPA1B/HSPA1A/CALR/DDIT3/HSPH1/DNAJB1/SKP1/HSPA6/HSPA8/MAN1A1/HSP90B1/OSTC/CRYAB/CANX/STT3B/ERN1/HERPUD1/DNAJC3/SAR1A/TRAM1/SSR3/ATF4/DNAJB11/DERL2/PDIA6/NFE2L2	8.57065389107917
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	28/377	216/9376	3.2238923273406	HSP90AA1/HSPD1/HSP90AB1/HSPA1B/HSPA1A/CD36/LDLR/DDIT3/RHOA/CDC42/CALM2/CCL3L1/HSPA6/HSPA8/CALM3/HSP90B1/ERN1/CXCL2/VCAM1/TANK/ATF4/FOS/TNFRSF1A/TAB2/GSK3B/JUN/CXCL3/NFE2L2	6.76787116274383
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	29/377	250/9376	2.88492307692308	RAB31/HSPA1B/HSPA1A/LDLR/HLA-A/ARF4/RHOA/CDC42/CLTC/WWP1/HSPA6/HSPA8/CLTA/HLA-G/CAPZA2/ARPC5/EPS15/VPS26A/ARPC3/SNX3/CHMP5/SNX2/AGAP1/TGFBR1/IQSEC3/ARPC1A/VPS28/SPART/KIF5B	6.18276288220765
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/377	248/9376	2.70762385556601	HSP90AA1/DYNLL1/HSP90AB1/AHNAK/MYL12A/TUBB4B/RHOA/CDC42/SKP1/ARL8A/RHOB/TUBB6/HSP90B1/MYL12B/ARPC5/TUBA1B/ARPC3/TUBA1A/DCTN5/GAPDH/DYNLRB1/FOS/ARPC1A/TNFRSF1A/TAB2/JUN/KIF5B	5.57814019791642
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/377	155/9376	3.20903568067083	MARCO/ATP6V0E1/CALR/CD36/ATP6V0C/ATP6V0B/HLA-A/TUBB4B/ATP6V1G1/HLA-DRB5/TUBB6/HLA-G/CANX/TUBA1B/STX7/MRC1/TUBA1A/ITGB5/COLEC12/ATP6V1B2	5.67595255017123
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/377	142/9376	3.15253857361677	HSP90AA1/HSP90AB1/KLF2/HMOX1/RHOA/CALM2/SUMO2/CALM3/HSP90B1/PDGFB/GSTP1/SUMO1/MEF2C/VCAM1/FOS/TNFRSF1A/JUN/NFE2L2	5.29004501048406
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/377	42/9376	5.32929139825692	FTL/HMOX1/FTH1/PCBP1/PRNP/PCBP2/GPX4/SLC3A2/SAT2	5.75528391610676
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/377	139/9376	3.04165792034807	HSP90AA1/SHC2/HSP90AB1/HSPA1B/HSPA1A/FKBP4/FKBP5/CALM2/HSPA6/HSPA8/CALM3/HSP90B1/ATF4/FOS/GNAQ/NCOA3/JUN	4.96345505417278
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/377	103/9376	3.38039195488141	SAP18/PCF11/PAPOLA/ETF1/PPP2R3A/SMG1/PPP1CB/RBM8A/PPP2R5C/SMG5/NXT1/DDX39B/CPSF7/FUS	4.97182854722306
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/377	56/9376	4.4410761652141	HSPD1/HSPA1B/HSPA1A/HSPA6/HSPA8/EEF1A1/CXCL2/SAR1A/CLK1/CXCL3	5.28615057997854
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/377	82/9376	3.63951607685838	HSP90AA1/HSP90AB1/HSPA1B/HSPA1A/CALR/B2M/HLA-A/HLA-DRB5/HSPA6/HSPA8/HLA-G/CANX	4.91347885111953
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/377	250/9376	2.2880424403183	CD63/ATP6V0E1/ATP6V0C/ATP6V0B/PPT1/CTSA/HEXB/CLTC/ATP6V1G1/LAPTM4A/ARL8A/CLTA/GLA/ASAH1/FUCA1/LAMTOR3/NEU1/VPS26A/MCOLN1/LAMTOR1/AP3S1/ATP6V1B2/NPC2	4.22492625200808
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	36/377	480/9376	1.86525198938992	DKK2/UBB/UBC/PRKCB/DDIT3/TUBB4B/DKK1/PRNP/CALM2/ATP2A2/CAT/PSMA2/PSMB3/TUBB6/CALM3/ERN1/TUBA1B/GRIN2D/SOD1/TUBA1A/GPX3/PARK7/DCTN5/TANK/C9orf72/ATF4/TNFRSF1A/GNAQ/GSK3B/SMCR8/NDUFC2/COX7A2L/PPID/SNCA/FUS/KIF5B	3.98313499361184
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/377	94/9376	3.17489700321689	HSP90AA1/HSP90AB1/JUND/HSP90B1/CXCL2/FOSB/CEBPB/FOS/TAB2/GSK3B/JUN/CXCL3	4.33751537284016
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	25/377	300/9376	2.07250221043324	HSPA1B/HSPA1A/JUND/PRKCB/DDIT3/CDC42/STMN1/HSPA6/HSPA8/GADD45B/LAMTOR3/HSPB1/PDGFB/TAOK1/DUSP10/MEF2C/STK4/TGFBR1/PDGFC/ATF4/FOS/TNFRSF1A/TAB2/JUN/INSR	3.86429939618186
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	28/377	368/9376	1.89228462691731	SRSF3/HNRNPA2B1/DDIT3/TUBB4B/CAT/PSMA2/PSMB3/TUBB6/HNRNPA1/ERN1/TUBA1B/GRIN2D/SOD1/TUBA1A/GPX3/DCTN5/SRSF7/TANK/C9orf72/NXT1/ATF4/TNFRSF1A/SMCR8/NDUFC2/SETX/COX7A2L/FUS/KIF5B	3.57414624376717
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/377	95/9376	2.87968728186514	ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/HLA-DRB5/CCL3L1/CXCL2/ATP6V1B2/FOS/JUN/CXCL3	3.76885306996842
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/377	69/9376	3.24391650328682	PRKCB/CALM2/CALM3/GRIN2D/PPP1CB/FOSB/ATF4/FOS/JUN	3.82900178213636
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	28/377	388/9376	1.79474418223085	DKK2/DDIT3/TUBB4B/DKK1/RTN3/CALM2/ATP2A2/APOE/PSMA2/PSMB3/TUBB6/CALM3/ERN1/TUBA1B/GRIN2D/SLC39A12/TUBA1A/GAPDH/ATF4/TNFRSF1A/GNAQ/GSK3B/NDUFC2/COX7A2L/PPID/INSR/SNCA/KIF5B	3.27243384549351
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/377	71/9376	3.15253857361677	ATP6V0E1/ATP6V0C/ATP6V0B/CDC42/ATP6V1G1/CXCL2/ATP6V1B2/JUN/CXCL3	3.72632830847822
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/377	196/9376	2.1570941373897	UBB/UBC/HLA-A/CALM2/CLEC2B/CALM3/HLA-G/IL6ST/PDGFB/ZFP36/CXCL2/FOS/TNFRSF1A/GSK3B/GNG11/JUN/CXCL3	3.35069251604533
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/377	268/9376	1.9487707351835	UBB/UBC/DDIT3/TUBB4B/CALM2/PSMA2/PSMB3/TUBB6/CALM3/ERN1/TUBA1B/SLC39A12/SOD1/TUBA1A/PARK7/ATF4/NDUFC2/COX7A2L/SNCA/KIF5B/NFE2L2	3.22534632166404
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/377	200/9376	2.11395225464191	TUBB4B/RHOA/CDC42/MYO1D/TMBIM6/TUBB6/ARPC5/TUBA1B/ARPC3/TUBA1A/EZR/GAPDH/FOS/ARPC1A/TNFRSF1A/TAB2/JUN	3.259222873811
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/377	62/9376	3.20903568067083	HSPA1B/HSPA1A/CAT/HSPA6/HSPA8/CRYAB/SOD1/INSR	3.57182066895449
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	19/377	238/9376	1.98542228562513	PRKCB/CFD/IL6ST/RPL14/OAS1/RPL10/RPS4X/RPL9/RPL7A/RPS9/RPL18A/RPS3A/C7/FOS/TNFRSF1A/TAB2/JUN/C1QB/RPS7	3.15169707612993
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/377	275/9376	1.89916566192428	HSPA1B/HSPA1A/DDIT3/TUBB4B/PRNP/PSMA2/PSMB3/HSPA6/HSPA8/TUBB6/TUBA1B/GRIN2D/SOD1/TUBA1A/C7/ATF4/GSK3B/NDUFC2/C1QB/COX7A2L/KIF5B	3.09756686867249
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/377	78/9376	2.86961844521526	SHC2/FN1/RHOA/CDC42/CLTC/CLTA/ARPC5/ARPC3/ARPC1A	3.3936316525034
Genetic Information Processing	Transcription	hsa03040	Spliceosome	19/377	243/9376	1.94456997522132	SRSF3/HSPA1B/HSPA1A/PCBP1/HNRNPK/HSPA6/HSPA8/HNRNPA1/SRSF2/RBM8A/TRA2B/SRSF7/TRA2A/SRSF6/BUD31/DDX39B/FUS/SRSF9/SF3B6	3.05344240096076
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/377	180/9376	2.07250221043324	SRSF3/BST2/CALR/B2M/HLA-A/HLA-DRB5/HLA-G/OAS1/SRSF2/PPP1CB/SRSF7/SRSF6/TNFRSF1A/TAB2/SRSF9	2.97367947039384
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/377	133/9376	2.24391216768712	PRKCB/CALM2/PPP2R3A/CALM3/PPP1CB/PPP2R5C/ATF4/FOS/GNAQ/GSK3B/GNG11/KIF5B	2.95711522561096
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/377	203/9376	1.96019913499105	SHC2/FN1/PRKCB/EMP2/MYL12A/RHOA/CDC42/MYL12B/PDGFB/LAMB2/ITGB5/PPP1CB/EMP1/PDGFC/GSK3B/JUN	2.83082368094102
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/377	44/9376	3.39136725343622	MAN2A1/HEXB/MAN1A1/OSTC/STT3B/MGAT1	3.25420148141458
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/377	89/9376	2.51494650254821	PRKCB/TUBB4B/TUBB6/HTR2B/TUBA1B/PDGFB/TUBA1A/PDGFC/GNAQ	2.93909595302762
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	12/377	138/9376	2.16261100219121	FN1/RHOA/CDC42/SKAP2/ARPC5/ARPC3/FOS/ARPC1A/TAB2/GNAQ/GSK3B/JUN	2.81607476041564
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	16/377	214/9376	1.85944123552889	BST2/CALR/B2M/PRKCB/HLA-A/CALM2/SKP1/CALM3/HLA-G/CUL4B/FOS/TNFRSF1A/TAB2/GNAQ/GNG11/JUN	2.6030776144807
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/377	50/9376	2.98440318302387	AOC1/P4HA1/OAT/AMD1/ODC1/SAT2	2.87956176927334
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/377	51/9376	2.92588547355282	ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/ATP6V1B2/SLC12A2	2.82260633949453
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/377	52/9376	2.86961844521526	CD36/LDLR/APOE/VAPA/LRPAP1/NPC2	2.76702262886785
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/377	67/9376	2.59836098024467	PRKCB/CALM2/CALM3/GRIN2D/PPP1CB/ATF4/GNAQ	2.68732345361786
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/377	83/9376	2.39711099038062	DHRS4/PRDX1/CAT/ABCD4/SOD1/PRDX5/PEX6/ECH1	2.61668336845853
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/377	187/9376	1.86192711953361	HSP90AA1/HSP90AB1/RHOA/TXNIP/OAS1/TRPM7/GABARAP/CXCL2/TANK/ANTXR2/NEK7/TAB2/JUN/CXCL3	2.43678049872519
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/377	137/9376	1.99686344362911	DDIT3/PMAIP1/GADD45B/ERN1/TUBA1B/TUBA1A/LMNA/ATF4/FOS/TNFRSF1A/JUN	2.40570658809592
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/377	28/9376	3.55286093217128	ATP6V0E1/ATP6V0C/ATP6V1G1/ATP6V1B2	2.76889194784513
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/377	158/9376	1.88886277406574	PRKCB/RHOA/ATP6V1G1/LAMTOR3/FNIP1/LAMTOR1/ATP6V1B2/SLC3A2/EIF4B/TNFRSF1A/GSK3B/INSR	2.30623785861484
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/377	106/9376	2.11160602572444	HSP90AA1/HSP90AB1/HSP90B1/PDGFB/GSTP1/PDGFC/ATF4/SLC46A1/GSK3B	2.35571715856756
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/377	142/9376	1.92655135054358	UBB/UBC/UBE2S/UBE2A/PIAS1/SKP1/WWP1/UBE2B/CUL4B/UBA6/UBE2W	2.27707805517495
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	9/377	108/9376	2.07250221043324	SAP18/SUMO2/RAN/SUMO1/EEF1A1/RBM8A/RANBP17/NXT1/DDX39B	2.29443758674897
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/377	59/9376	2.52915523985074	HPGDS/ODC1/GSTP1/GPX3/GPX4/PRDX6	2.41156361484555
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/377	18/9376	4.14500442086649	HEXB/FUCA1/NEU1	2.73353840414273
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/377	61/9376	2.44623211723268	FTL/HMOX1/FTH1/TRPM7/ATP2B4/SLC46A1	2.31937342721032
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/377	166/9376	1.79783324278547	KCNMA1/RHOA/CALM2/ATP2A2/CALM3/ADORA3/PPP1CB/MEF2C/ATP2B4/ATF4/GNAQ/INSR	2.12273384375328
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/377	112/9376	1.99848427434634	HSPA1B/HSPA1A/LDLR/HLA-DRB5/HSPA6/HSPA8/LAMB2/TNFRSF1A/TAB2	2.17575582482158
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/377	79/9376	2.20367323641003	ATP6V0E1/ATP6V0C/ATP6V0B/CLTC/ATP6V1G1/CLTA/ATP6V1B2	2.19892249272961
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/377	170/9376	1.75553128413169	YBX3/MYL12A/RHOA/CDC42/MYL12B/ARPC5/TUBA1B/ARPC3/TUBA1A/EZR/ARPC1A/JUN	2.0347010752775
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/377	115/9376	1.94634990197209	JUND/PRKCB/RHOA/PDE4D/MEF2C/ATF4/FOS/GNAQ/WNK1	2.08992599057241
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/377	253/9376	1.57280800159361	UBB/UBC/MYL12A/RHOA/CDC42/SKP1/MYL12B/ARPC5/ARPC3/CALCOCO2/ARPC1A/TNFRSF1A/TAB2/GSK3B/JUN/PPID	1.89042602107404
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/377	194/9376	1.66654816921436	DYNLL1/MYL12A/TUBB4B/MYO1D/KIF16B/TUBB6/MYL12B/CAPZA2/TUBA1B/TUBA1A/DCTN5/DYNLRB1/KIF5B	1.92009602280755
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/377	119/9376	1.88092637585538	CXCL2/VCAM1/CEBPB/ATF4/FOS/TNFRSF1A/TAB2/JUN/CXCL3	1.97941633366823
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/377	157/9376	1.74248593488655	HLA-A/CALM2/IGFBP3/CALM3/HLA-G/GADD45B/TRPM7/PPP1CB/HIPK1/TGFBR1/PPID	1.92023922667134
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	11/377	157/9376	1.74248593488655	DDIT3/CDC42/ERN1/ATF4/FOS/TNFRSF1A/GSK3B/NDUFC2/JUN/COX7A2L/INSR	1.92023922667134
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/377	103/9376	1.93165254564652	CALR/CCL3L1/TGFBR1/FOS/TNFRSF1A/GNAQ/JUN/C1QB	1.94590504855288
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/377	103/9376	1.93165254564652	FN1/PRKCB/PRDX1/HSPB1/LAMB2/CXCL2/GNAQ/CXCL3	1.94590504855288
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/377	87/9376	2.00103661697003	RHOA/PMAIP1/GADD45B/TGFBR1/FOS/GSK3B/JUN	1.9199251431051
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/377	53/9376	2.3462289174716	PRKCB/CLTC/CLTA/ATP2B4/GNAQ	2.01158410463293
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/377	23/9376	3.24391650328682	CTSA/PRCP/ATP6AP2	2.20523222864794
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/377	55/9376	2.26091150229081	HEXB/GLA/PLPP3/ASAH1/NEU1	1.91952549438291
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/377	109/9376	1.82532304772102	HSP90AA1/HSP90AB1/HLA-DRB5/EBI3/IL6ST/TGFBR1/FOS/JUN	1.7738905826344
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/377	56/9376	2.22053808260705	MAN2A1/MAN1A1/OSTC/STT3B/MGAT1	1.8749797399087
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	14/377	227/9376	1.5338342350343	CALR/B2M/PRKCB/HLA-A/RHOA/CALM2/CCL3L1/CALM3/HLA-G/ATF4/TNFRSF1A/GNAQ/GSK3B/GNG11	1.66644783730812
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/377	110/9376	1.80872920183265	DCN/RGMA/RHOA/SKP1/SMAD5/TGFBR1/BMP5/PITX2	1.74627447912475
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/377	169/9376	1.61875912294194	UBB/UBC/WDFY3/GABARAP/ERN1/UVRAG/STX7/CALCOCO2/TANK/C9orf72/SMCR8	1.66136510093465
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/377	93/9376	1.87193748039132	PRKCB/CDC42/CALM2/CALM3/ATF4/GNAQ/JUN	1.72958469165099
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/377	93/9376	1.87193748039132	KCNMA1/PRKCB/CALM2/CALM3/ATP2B4/SLC12A2/GNAQ	1.72958469165099
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/377	75/9376	1.98960212201592	PRKCB/HSP90B1/CANX/GPX3/ATF4/GNAQ	1.76110647886108
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/377	232/9376	1.50077746272752	FN1/MYL12A/RHOA/CDC42/MYL12B/ARPC5/PDGFB/ARPC3/ITGB5/PPP1CB/EZR/C7/PDGFC/ARPC1A	1.58081062611154
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/377	76/9376	1.96342314672623	SHC2/PRKCB/CALM2/CALM3/GADD45B/PDGFB	1.72600315606939
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/377	133/9376	1.68293412576534	KLF2/HOMER1/CAT/GADD45B/GABARAP/HOMER3/STK4/TGFBR1/INSR	1.62351888971792
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/377	154/9376	1.61493678735058	CALM2/ATP2A2/PPP2R3A/CALM3/CREM/PPP1CB/PPP2R5C/ATP2B4/ATF4/GNAQ	1.57484372194978
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/377	78/9376	1.91307896347684	RHOA/CALM2/CALM3/FOS/JUN/C1QB	1.65737221924618
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/377	78/9376	1.91307896347684	PRKCB/HLA-DRB5/EEF1A1/FOS/TAB2/JUN	1.65737221924618
NA	NA	hsa04517	IgSF CAM signaling	17/377	299/9376	1.4140148860481	DYNLL1/PRKCB/MYL12A/TUBB4B/RHOA/CDC42/TUBB6/MYL12B/ARPC5/TUBA1B/ARPC3/TUBA1A/EZR/EPB41L2/ARPC1A/GSK3B/ROBO1	1.48915385617997
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/377	116/9376	1.71517424311717	PRKCB/SLC38A2/HOMER1/HOMER3/GRIN2D/GNAQ/GNG11/GLUL	1.58633371179852
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/377	97/9376	1.79474418223085	PRKCB/CALM2/CALM3/GRIN2D/FOS/GNAQ/GNG11	1.61035573617062
Human Diseases	Infectious disease: viral	hsa05162	Measles	9/377	136/9376	1.64581057887346	HSPA1B/HSPA1A/HSPA6/HSPA8/OAS1/FOS/TAB2/GSK3B/JUN	1.55273667430036
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/377	98/9376	1.77643046608564	PRKCB/LDLR/CALM2/CALM3/ATP2B4/ATF4/GNAQ	1.58142139235396
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/377	44/9376	2.26091150229081	HSPD1/HLA-A/HLA-DRB5/HLA-G	1.7158636227001
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/377	80/9376	1.86525198938992	SHC2/PRKCB/AXL/PDGFB/PDGFC/GSK3B	1.59073827148416
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/377	45/9376	2.21066902446213	ABCC5/ABCD4/ABCA6/ABCA9	1.66619865858146
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	8/377	120/9376	1.6580017683466	SHC2/RHOA/CDC42/CALM2/CALM3/ATF4/GSK3B/JUN	1.48479056164223
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/377	46/9376	2.16261100219121	FTL/HMOX1/FTH1/BLVRB	1.61782562457799
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/377	181/9376	1.51143807611706	HSPD1/ATP6V0C/ATP6V0B/RHOA/CALM2/HLA-DRB5/HSPA9/CALM3/MRC1/CEBPB/TNFRSF1A	1.42205261658033
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/377	102/9376	1.70676652623914	KCNMA1/PRKCB/RHOA/ATP2A2/ATP2B4/SLC12A2/GNAQ	1.46893202704862
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/377	224/9376	1.44334975369458	CALR/B2M/HLA-A/HLA-DRB5/HLA-G/CANX/RAN/ZFP36/TGFBR1/ATF4/FOS/TNFRSF1A/JUN	1.37458519608745
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/377	30/9376	2.48700265251989	DHFR/ABCC5/SLC46A1	1.66962396449017
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/377	205/9376	1.45580643074335	HLA-A/RHOA/CDC42/GTF2B/PMAIP1/DDX3X/HNRNPK/HLA-G/IL6ST/ATF4/EGR3/JUN	1.35054238758086
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/377	144/9376	1.55437665782493	PRKCB/GTF2B/ATP2A2/PSMA2/PSMB3/ERN1/GRIN2D/PUM2/GNAQ	1.37213698766613
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/377	31/9376	2.40677676050312	SPCS2/SEC11A/SRPRB	1.60574125967931
NA	NA	hsa04981	Folate transport and metabolism	3/377	31/9376	2.40677676050312	DHFR/ABCC5/SLC46A1	1.60574125967931
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/377	105/9376	1.6580017683466	PRKCB/GADD45B/CXCL2/VCAM1/TNFRSF1A/TAB2/CXCL3	1.38777035859431
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/377	105/9376	1.6580017683466	UBB/CCZ1B/UBC/GABARAP/CALCOCO2/ATF4/JUN	1.38777035859431
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/377	125/9376	1.59168169761273	PRKCB/RHOA/PPP2R3A/ADORA3/ASAH1/PPP2R5C/TNFRSF1A/GNAQ	1.36303807938517
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/377	49/9376	2.03020624695502	GRIN2D/FOSB/ATF4/JUN	1.47982519790457
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/377	16/9376	3.10875331564987	HEXB/GLA	1.72785396051016
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/377	33/9376	2.26091150229081	SNAP23/STX7/VAMP5	1.48510646740194
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/377	18/9376	2.76333628057766	PRDX1/ABCD4	1.53263614206597
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/377	154/9376	1.45344310861552	PRKCB/RHOA/CALM2/CALM3/PPP1CB/MEF2C/FOS/GNAQ/JUN	1.16126087681502
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/377	93/9376	1.60451784033542	MYL12A/RHOA/CDC42/MYL12B/TGFBR1/INSR	1.19912817832399
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	16/377	308/9376	1.29194942988046	TUBB4B/CLTC/PSMA2/PSMB3/CLTA/TUBB6/ERN1/TUBA1B/SOD1/TUBA1A/GPX3/DCTN5/GNAQ/NDUFC2/COX7A2L/KIF5B	1.06631721683672
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/377	157/9376	1.42567031036172	CALR/CD36/ATP2A2/AXL/ODC1/ITGB5/CEBPB/ATP8A1/C1QB	1.10088122775125
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/377	75/9376	1.6580017683466	IGFBP3/PMAIP1/GADD45B/PPM1D/EI24	1.17098695683537
Genetic Information Processing	Translation	hsa03010	Ribosome	12/377	222/9376	1.34432575811886	MRPS6/MRPL18/RPL14/RPL10/RPS4X/RPL9/RPL7A/RPS9/RPL18A/RPS3A/MRPL14/RPS7	1.06267321193606
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/377	37/9376	2.01648863717829	PRKCB/VCAM1/GNAQ	1.26797996071663
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/377	116/9376	1.50077746272752	PRKCB/MYL12A/RHOA/CDC42/MYL12B/EZR/VCAM1	1.11077849751847
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/377	76/9376	1.63618595560519	PRKCB/CALM2/CALM3/EZR/GNAQ	1.13974733838693
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/377	38/9376	1.96342314672623	PRKCB/NR3C2/INSR	1.21798272089557
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	11/377	204/9376	1.34103084204504	CD63/FN1/DCN/PRKCB/LUM/RHOA/CDC42/ITGB5/PPP1CB/EZR/EIF4B	1.00794284298223
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/377	98/9376	1.52265468521626	PRKCB/CDC42/PLPP3/ARPC5/ARPC3/ARPC1A	1.06453486322091
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/377	205/9376	1.33448922818141	PRKCB/CD36/ATP2A2/PDK4/PPP1CB/GAPDH/TGFBR1/GSK3B/NDUFC2/COX7A2L/INSR	0.99108272805952
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/377	78/9376	1.59423246956403	HSPD1/TOB1/HSPA9/CNOT1/TOB2	1.0786190748271
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/377	39/9376	1.91307896347684	HLA-A/HLA-DRB5/HLA-G	1.16948901985756
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/377	99/9376	1.50727433486054	PRKCB/CALM2/CALM3/HTR2B/PPP1CB/GNAQ	1.03852246736255
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/377	99/9376	1.50727433486054	PRKCB/PLPP3/PDGFB/PDGFC/FOS/JUN	1.03852246736255
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	8/377	142/9376	1.40112825494079	JUND/ATP2A2/FOSB/TGFBR1/FOS/TNFRSF1A/TAB2/JUN	0.985806502899619
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/377	122/9376	1.4269687350524	RHOA/CDC42/PPP2R3A/PPP2R5C/FOS/GSK3B/JUN	0.971561798081834
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/377	122/9376	1.4269687350524	SHC2/PRKCB/IGFBP3/ATF4/FOS/GNAQ/GSK3B	0.971561798081834
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/377	101/9376	1.47742731832865	FN1/PRKCB/CDC42/VCAM1/TGFBR1/JUN	0.987347840881927
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/377	60/9376	1.6580017683466	SHC2/PRKCB/CDC42/HSPB1	1.04651903823487
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/377	22/9376	2.26091150229081	AOC1/HNMT	1.21187116331835
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/377	144/9376	1.38166814028883	TRA2B/TRA2A/CXCL2/TNFRSF1A/TAB2/GSK3B/CXCL3/C1QB	0.944666347170465
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/377	168/9376	1.33232284956423	HSP90AA1/HSP90AB1/FTL/FTH1/TRPM7/CHMP5/TNFRSF1A/GLUL/PPID	0.889593039335828
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/377	170/9376	1.31664846309877	SHC2/PRKCB/HMOX1/GADD45B/GSTP1/TGFBR1/GSK3B/NFE2L2/PBRM1	0.852757499105398
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/377	63/9376	1.57904930318723	PTGES3/HPGDS/PTGDS/GPX4	0.943843966556162
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/377	193/9376	1.28860241063207	SHC2/PRKCB/RHOA/CDC42/CCL3L1/CXCL2/GNAQ/GSK3B/GNG11/CXCL3	0.829173672375792
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/377	107/9376	1.39458092664667	CALM2/CALM3/PPP4C/ATF4/GNAQ/PPP4R3B	0.840176874389777
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	16/377	333/9376	1.19495622943899	ATP6V0E1/FN1/ATP6V0C/ATP6V0B/HLA-A/CDC42/ATP6V1G1/PPP2R3A/HLA-G/NOTCH2/LAMB2/ITGB5/PPP2R5C/ATP6V1B2/TNFRSF1A/GSK3B	0.741416343959161
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/377	45/9376	1.6580017683466	HLA-A/HLA-DRB5/HLA-G	0.905583311054329
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/377	109/9376	1.36899228579077	PRKCB/CD36/PPP1CB/TNFRSF1A/GSK3B/INSR	0.793085740954898
NA	NA	hsa04518	Integrin signaling	8/377	154/9376	1.29194942988046	FN1/CDC42/PDGFB/LAMB2/ITGB5/VCAM1/PDGFC/GSK3B	0.747678031680263
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/377	88/9376	1.41306968893176	CFD/CD59/SERPINE2/C7/C1QB	0.796824626254307
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/377	26/9376	1.91307896347684	ABCD4/SLC46A1	0.954219732292131
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/377	89/9376	1.39719250141567	PRKCB/SLC38A2/GABARAP/GNG11/GLUL	0.770579602329268
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/377	178/9376	1.2574732512741	DKK2/CACYBP/PRKCB/RHOA/DKK1/NOTUM/SKP1/GSK3B/JUN	0.709830413218567
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/377	201/9376	1.23731475249746	NUPR1/DDIT3/IGFBP3/NR4A3/GADD45B/MAF/MEF2C/CEBPB/FUS/LYL1	0.696111672762174
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/377	134/9376	1.29918049012233	KCNMA1/PRKCB/RHOA/CALM2/CALM3/PPP1CB/GNAQ	0.713940261198888
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/377	69/9376	1.44174066812747	KCNMA1/CALM2/CALM3/GNAQ	0.753782862697726
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/377	70/9376	1.42114437286851	HLA-A/HLA-DRB5/HLA-G/EIF4G2	0.723865178695236
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/377	28/9376	1.77643046608564	PPT1/HACD2	0.842134422017912
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/377	93/9376	1.33709820027951	HLA-DRB5/NOTCH2/MAF/FOS/JUN	0.668671664996991
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/377	138/9376	1.26152308461154	ATP6V0E1/ATP6V0C/ATP6V0B/ATP6V1G1/ATP6V1B2/NDUFC2/COX7A2L	0.633460853589511
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/377	138/9376	1.26152308461154	CALM2/SPDYE2/SKP1/CPEB4/CALM3/PPP1CB/PPP2R5C	0.633460853589511
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/377	50/9376	1.49220159151194	CD36/GYPC/VCAM1	0.714232318219485
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/377	29/9376	1.71517424311717	CALM2/CALM3	0.789466907225831
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/377	140/9376	1.24350132625995	KLF2/CALM2/CALM3/MEF2C/TGFBR1/GNAQ/GNG11	0.594131493774323
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/377	163/9376	1.22061479878277	PRKCB/DDX3X/TGFBR1/ATF4/FOS/TAB2/EGR3/JUN	0.581550047394558
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/377	73/9376	1.36274117946296	BST2/RAN/SERINC3/CPSF7	0.636804271355572
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/377	73/9376	1.36274117946296	PRKCB/GADD45B/STK4/KIF5B	0.636804271355572
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/377	31/9376	1.60451784033542	CAT/GLUL	0.690016543983596
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/377	98/9376	1.26887890434688	PRKCB/CALM2/CALM3/PIP4P1/IP6K1	0.547648334087857
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	11/377	238/9376	1.14945500746718	SHC2/PRKCB/RHOA/CDC42/CALM2/CALM3/PDGFB/STK4/PDGFC/GNG11/INSR	0.478005132336203
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/377	122/9376	1.22311605861634	THRB/PRKCB/ATP2A2/NOTCH2/GSK3B/NCOA3	0.507697686725521
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/377	99/9376	1.25606194571712	SHC2/NOTCH2/FOS/NCOA3/JUN	0.524225385336919
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/377	54/9376	1.38166814028883	HLA-A/HLA-DRB5/HLA-G	0.57568833130787
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/377	32/9376	1.55437665782493	PMAIP1/TNFRSF1A	0.642943333462621
Human Diseases	Immune disease	hsa05310	Asthma	2/377	32/9376	1.55437665782493	PRG2/HLA-DRB5	0.642943333462621
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/377	217/9376	1.14608417166815	HSP90AA1/HSP90AB1/PTGES3/PRKCB/KLF4/HSP90B1/NOTCH2/ATF4/FOS/JUN	0.445623604477169
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/377	100/9376	1.24350132625995	CCL3L1/IL6ST/CXCL2/TNFRSF1A/CXCL3	0.501048940825965
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/377	101/9376	1.23118943194054	PRKCB/CALM2/CALM3/GNAQ/GSK3B	0.478113374953716
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/377	148/9376	1.176285038354	SHC2/GADD45B/NOTCH2/FOS/GSK3B/NCOA3/JUN	0.442437272778873
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/377	173/9376	1.150059030067	PRKCB/DNAJB1/HLA-DRB5/OAS1/CALCOCO2/DNAJC3/NXT1/TNFRSF1A	0.407736567882963
Organismal Systems	Immune system	hsa04611	Platelet activation	6/377	126/9376	1.18428697739043	MYL12A/RHOA/SNAP23/MYL12B/PPP1CB/GNAQ	0.426253777267173
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/377	34/9376	1.46294273677641	SKP1/CRY1	0.553485170286136
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/377	105/9376	1.18428697739043	RHOA/CALM2/CALM3/EGR3/JUN	0.388673734631454
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/377	226/9376	1.10044365155748	RHOA/PDE4D/CALM2/ATP2A2/CALM3/GRIN2D/PPP1CB/ATP2B4/FOS/JUN	0.312842215425877
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/377	130/9376	1.1478473780861	SHC2/TGFBR1/ATF4/FOS/GNG11/JUN	0.347430183877103
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/377	83/9376	1.19855549519031	AUTS2/SKP1/RYBP/CBX6	0.371879446627922
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	9/377	205/9376	1.09185482305751	CALR/B2M/HLA-A/HLA-DRB5/HLA-G/GADD45B/OAS1/TAB2/JUN	0.272163409016848
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/377	254/9376	1.07704839282358	PRKCB/CALM2/ATP2A2/CALM3/HTR2B/PDGFB/GRIN2D/MCOLN1/ATP2B4/PDGFC/GNAQ	0.254797167524915
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/377	38/9376	1.30894876448415	HEXB/NAGK	0.390580460997233
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/377	86/9376	1.15674541977669	SHC2/PRKCB/GSK3B/JUN	0.298879009504175
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/377	86/9376	1.15674541977669	KCNMA1/PRKCB/ATF4/GNAQ	0.298879009504175
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/377	15/9376	1.6580017683466	HEXB	0.522000302962347
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/377	184/9376	1.08130550109561	MYL12A/RGMA/RHOA/CDC42/MYL12B/DPYSL2/GSK3B/ROBO1	0.227972793956795
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/377	63/9376	1.18428697739043	ERCC5/RPA1/CUL4B	0.300385737047649
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/377	16/9376	1.55437665782493	MIF	0.454240852511475
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/377	138/9376	1.08130550109561	SHC2/CALM2/CALM3/PPP1CB/GSK3B/INSR	0.196938072224286
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/377	212/9376	1.05580301286222	PRKCB/RHOA/CDC42/CALM2/CALM3/PDGFB/PDGFC/GNAQ/INSR	0.168206287351599
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/377	89/9376	1.11775400113254	FN1/CD36/LAMB2/ITGB5	0.228450514654681
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/377	65/9376	1.1478473780861	LDLR/ATF4/GNAQ	0.244811226424402
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	15/377	362/9376	1.03052596098891	HSP90AA1/HSP90AB1/FN1/PPP2R3A/HSP90B1/PDGFB/LAMB2/ITGB5/PPP2R5C/EIF4B/PDGFC/ATF4/GSK3B/GNG11/INSR	0.121233890052428
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/377	115/9376	1.08130550109561	PRKCB/ATF4/FOS/GNAQ/GNG11	0.179555658601666
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/377	66/9376	1.13045575114541	HLA-DRB5/MAF/JUN	0.21768050906949
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/377	91/9376	1.09318797912962	PRKCB/FOS/GSK3B/JUN	0.182830574220213
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/377	91/9376	1.09318797912962	PRKCB/PDE4D/PDE7B/GNG11	0.182830574220213
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/377	17/9376	1.46294273677641	GLUL	0.391017504038234
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/377	191/9376	1.04167650367325	SHC2/CALM2/CALM3/GRIN2D/PPP1CB/FOSB/ATF4/GNG11	0.119104335008236
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/377	42/9376	1.18428697739043	AOC1/CAT	0.244987869689271
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/377	93/9376	1.06967856022361	FN1/GADD45B/LAMB2/CKS2	0.138215151669993
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/377	43/9376	1.15674541977669	CD36/PLPP3	0.21085195957698
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/377	44/9376	1.13045575114541	DYNLL1/DCTN5	0.17752576398561
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/377	70/9376	1.06585827965138	SULT1A1/HPGDS/GSTP1	0.113197559885938
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/377	70/9376	1.06585827965138	CDC42/PDGFB/JUN	0.113197559885938
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/377	19/9376	1.30894876448415	HEXB	0.27590154718728
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/377	71/9376	1.05084619120559	SHC2/FOS/GSK3B	0.088021466369975
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/377	46/9376	1.08130550109561	PSMA2/PSMB3	0.11314027034297
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/377	149/9376	1.00147757819593	SHC2/RHOA/PLPP3/PDGFB/PDGFC/INSR	0.00372111022818521
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/377	20/9376	1.24350132625995	CYP51A1	0.223115842954491
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/377	20/9376	1.24350132625995	NPL	0.223115842954491
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/377	227/9376	0.986036293950619	AS3MT/HMOX1/CAT/SOD1/FOS/NDUFC2/JUN/COX7A2L/NFE2L2	-0.0435899127850103
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/377	73/9376	1.02205588459722	GADD45B/PDGFB/PDGFC	0.0387198430043907
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/377	100/9376	0.994801061007958	CD37/CD36/HLA-DRB5/CD59	-0.0106977769500967
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/377	21/9376	1.18428697739043	CSGALNACT1	0.173038039437216
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/377	21/9376	1.18428697739043	VNN1	0.173038039437216
NA	NA	hsa03272	Virion - Hepatitis viruses	2/377	48/9376	1.03625110521662	CD63/LDLR	0.0515355350322784
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/377	128/9376	0.971485411140584	PDE4D/NUDT2/PDE7B/APRT/AK6	-0.0664825051259943
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/377	156/9376	0.956539481738421	LDLR/PIAS1/OAS1/EIF3E/TNFRSF1A/GSK3B	-0.112034279872778
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/377	77/9376	0.968962072410348	CDC42/GADD45B/TGFBR1	-0.0559730718130185
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/377	77/9376	0.968962072410348	SHC2/GADD45B/TGFBR1	-0.0559730718130185
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/377	23/9376	1.08130550109561	GLUL	0.0799038249060387
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/377	23/9376	1.08130550109561	RPA1	0.0799038249060387
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/377	133/9376	0.934963403202968	ULBP2/SHC2/PRKCB/HLA-A/HLA-G	-0.154609558139478
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/377	52/9376	0.956539481738421	LDLR/INSR	-0.0643212725034215
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/377	24/9376	1.03625110521662	HS3ST2	0.0363943368973101
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/377	109/9376	0.912661523860512	CCL3L1/FOS/TAB2/JUN	-0.187719100724601
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/377	110/9376	0.904364600916325	PRKCB/HMOX1/GAPDH/INSR	-0.206503804168668
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/377	110/9376	0.904364600916325	HSP90AA1/HSP90AB1/SPDYE2/CPEB4	-0.206503804168668
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/377	83/9376	0.898916621392733	PCBP1/G3BP1/POLR1D	-0.189321533829731
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/377	27/9376	0.921112093525887	HACD2	-0.0840173386261574
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/377	85/9376	0.877765642065845	APRT/CMPK1/AK6	-0.231702497929957
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/377	57/9376	0.872632509656103	PPT1/HACD2	-0.197410637460318
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/377	86/9376	0.867559064832521	ATP2A2/ITGB5/LMNA	-0.252535707755004
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/377	28/9376	0.888215233042819	B3GNT5	-0.121244340895698
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/377	28/9376	0.888215233042819	DHFR	-0.121244340895698
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/377	115/9376	0.865044400876485	PRKCB/HTR2B/GNAQ/GNG11	-0.29803692439102
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/377	59/9376	0.843051746616913	NUDT2/CMPK1	-0.247516202023515
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/377	59/9376	0.843051746616913	GADD45B/GSK3B	-0.247516202023515
NA	NA	hsa04082	Neuroactive ligand signaling	7/377	199/9376	0.874825053650214	PRKCB/ADORA3/HTR2B/P2RY14/GRIN2D/GNAQ/GNG11	-0.365302608759844
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/377	29/9376	0.857587121558584	MOB1A	-0.15720680068431
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/377	60/9376	0.829000884173298	PRKCB/GNAQ	-0.271965576450717
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/377	90/9376	0.829000884173298	CAT/ATF4/INSR	-0.333626060482815
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/377	31/9376	0.802258920167708	HSD17B14	-0.225708171712115
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/377	31/9376	0.802258920167708	HIBCH	-0.225708171712115
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/377	63/9376	0.789524651593617	GADD45B/GSK3B	-0.343072492460863
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/377	122/9376	0.815410705744228	CD36/PPP2R3A/PPP2R5C/INSR	-0.420030535987105
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/377	32/9376	0.777188328912467	GLA	-0.258407846941915
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/377	32/9376	0.777188328912467	HIBCH	-0.258407846941915
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/377	32/9376	0.777188328912467	GABARAP	-0.258407846941915
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/377	65/9376	0.765231585390737	GLA/PLPP3	-0.388738334424395
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/377	65/9376	0.765231585390737	PRKCB/GNAQ	-0.388738334424395
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/377	34/9376	0.731471368388204	POLR1D	-0.321047515356401
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/377	157/9376	0.792039061312068	PPP1CB/MOB1A/TGFBR1/BMP5/GSK3B	-0.537834770088913
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/377	35/9376	0.710572186434255	HSD17B14	-0.351104816609083
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/377	68/9376	0.731471368388204	ALDH1A1/DHRS4	-0.454858228049235
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/377	99/9376	0.753637167430271	CFD/HLA-DRB5/C1QB	-0.504368778714343
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/377	99/9376	0.753637167430271	ATP2A2/ITGB5/LMNA	-0.504368778714343
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/377	36/9376	0.690834070144415	RPA1	-0.380389594363438
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/377	70/9376	0.710572186434255	CD36/TNFRSF1A	-0.497470058923359
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/377	37/9376	0.672162879059431	GLUL	-0.408947906083443
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/377	37/9376	0.672162879059431	MIF	-0.408947906083443
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/377	37/9376	0.672162879059431	NAGK	-0.408947906083443
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/377	37/9376	0.672162879059431	GADD45B	-0.408947906083443
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/377	103/9376	0.724369704617445	SLC38A2/PRCP/SLC3A2	-0.575697867005598
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/377	38/9376	0.654474382242077	NAPRT	-0.436821798901107
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/377	72/9376	0.690834070144415	DDX3X/TANK	-0.53899186855659
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/377	73/9376	0.681370589731478	HPGDS/GSTP1	-0.559364585346791
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/377	39/9376	0.637692987825614	DHFR	-0.464049758568433
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/377	105/9376	0.710572186434255	ATP2A2/ITGB5/LMNA	-0.610422889331402
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/377	75/9376	0.663200707338638	GAPDH/GLUL	-0.599371609241775
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/377	75/9376	0.663200707338638	PMAIP1/GSTP1	-0.599371609241775
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/377	41/9376	0.60658601280973	RPA1	-0.51670629326212
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/377	41/9376	0.60658601280973	GRIN2D	-0.51670629326212
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/377	76/9376	0.654474382242077	UBC/CD36	-0.619020114660445
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/377	79/9376	0.629620924688581	HPGDS/GSTP1	-0.676624564626638
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/377	44/9376	0.565227875572703	GTF2B	-0.591643165371634
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/377	44/9376	0.565227875572703	MBD4	-0.591643165371634
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/377	144/9376	0.690834070144415	KLF4/IL6ST/SMAD5/GSK3B	-0.765216214812214
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/377	82/9376	0.60658601280973	GSTP1/CMPK1	-0.732343069527632
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/377	116/9376	0.643190341168938	HIBCH/CAT/GAPDH	-0.791442359601743
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/377	47/9376	0.529149500536148	INSR	-0.662328747249437
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/377	149/9376	0.667651718797287	PRKCB/GNAQ/GNG11/NDUFC2	-0.836980805421554
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/377	150/9376	0.663200707338638	SHC2/GADD45B/TGFBR1/GSK3B	-0.85107780047333
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/377	48/9376	0.518125552608311	HIBCH	-0.685045526648579
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/377	48/9376	0.518125552608311	PRKCB	-0.685045526648579
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/377	183/9376	0.679508921453523	PWP2/RAN/EIF6/NXT1/AK6	-0.896132125895143
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/377	87/9376	0.571724747705723	ATP2A2/COX7A2L	-0.821404942746546
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/377	50/9376	0.497400530503979	HLA-DRB5	-0.729320649149752
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/377	154/9376	0.645974714940232	DHFR/NAPRT/CMPK1/AK6	-0.906653348858769
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/377	155/9376	0.641807136134166	LDLR/ATF4/GNAQ/GSK3B	-0.920349868905249
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/377	51/9376	0.487647578925469	PLPP3	-0.750911314114899
NA	NA	hsa04081	Hormone signaling	6/377	219/9376	0.681370589731478	THRB/RHOA/SMAD5/GNAQ/GNG11/INSR	-0.976541035178276
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/377	90/9376	0.552667256115532	FOS/JUN	-0.872763934162041
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/377	158/9376	0.629620924688581	SKP1/GADD45B/PPP2R5C/GSK3B	-0.960983259108539
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/377	160/9376	0.621750663129974	HLA-A/HLA-DRB5/HLA-G/VCAM1	-0.987702427152916
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/377	54/9376	0.460556046762943	AMD1	-0.813669144713388
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/377	54/9376	0.460556046762943	RPA1	-0.813669144713388
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/377	56/9376	0.44410761652141	GSK3B	-0.853956932147178
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/377	59/9376	0.421525873308457	INSR	-0.912286156240781
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/377	233/9376	0.640429867601689	FN1/DCN/MYOM2/CAPZA2/ITGB5/LMNA	-1.13756546250961
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/377	298/9376	0.667651718797287	CCL3L1/EBI3/IL6ST/CXCL2/TGFBR1/BMP5/TNFRSF1A/CXCL3	-1.1933440369491
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/377	62/9376	0.401129460083854	NOTCH2	-0.968322146725509
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/377	104/9376	0.47826974086921	PLPP3/ETNK1	-1.09505308009793
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/377	143/9376	0.521748808220957	HLA-DRB5/C7/C1QB	-1.17953776264821
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/377	67/9376	0.371194425749238	GAPDH	-1.0572104726875
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/377	323/9376	0.615975889169014	PRKCB/HMOX1/RHOA/STMN1/HNRNPK/NOTCH2/PDGFB/EZR	-1.43754907862219
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/377	117/9376	0.425128658550409	MORF4L2/PBRM1	-1.28068031723834
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/377	78/9376	0.318846493912807	IP6K1	-1.2363935028492
NA	NA	hsa04519	Cadherin signaling	10/377	404/9376	0.615594715970271	RHOA/CDC42/MYO1D/ARPC5/TAOK1/ARPC3/PPP1CB/MOB1A/ARPC1A/GSK3B	-1.61657026560637
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/377	168/9376	0.44410761652141	PIAS1/IL6ST/PDGFB	-1.48806498142036
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/377	86/9376	0.289186354944174	SCN9A	-1.35536514227336
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/377	90/9376	0.276333628057766	LDLR	-1.41190180784127
NA	NA	hsa04382	Cornified envelope formation	2/377	217/9376	0.229216834333631	PPP2R3A/PPP2R5C	-2.35124153857559
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/377	370/9376	0.336081439529715	THRB/ADORA3/HTR2B/P2RY14/GRIN2D	-2.66691324361539
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/377	235/9376	0.211659800214459	NDUFC2/COX7A2L	-2.50501272959039
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/377	195/9376	0.127538597565123	PRKCB	-2.51986759897884
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/377	449/9376	0.110779628174606	CALM2/CALM3	-3.95220073173272