category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/18	94/9376	22.1654846335697	JUN/JUND/NFKBIA/HSP90AA1	9.04485756615412
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/18	137/9376	15.2084347120843	JUN/GADD45B/SPTAN1/NFKBIA	7.34724304400201
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/18	142/9376	14.6729264475743	JUN/PLCG2/JUND/NFKBIA	7.20014238731206
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/18	71/9376	22.0093896713615	JUN/PLCG2/NFKBIA	7.79318152270884
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/18	205/9376	10.1636856368564	JUN/GADD45B/PLCG2/NFKBIA	5.81793863632635
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/18	91/9376	17.1721611721612	JUN/PLCG2/NFKBIA	6.79873593419895
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	4/18	216/9376	9.64609053497942	JUN/HSPA2/NFKBIA/HSP90AA1	5.63805473664681
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/18	93/9376	16.8028673835125	FN1/GADD45B/NFKBIA	6.71681775536952
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/18	101/9376	15.4719471947195	FN1/JUN/PLCG2	6.41299745062335
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/18	105/9376	14.8825396825397	GADD45B/PLCG2/NFKBIA	6.27379975435899
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/18	105/9376	14.8825396825397	JUN/PLCG2/NFKBIA	6.27379975435899
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/18	109/9376	14.3363914373089	JUN/NFKBIA/HSP90AA1	6.14203620045532
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/18	120/9376	13.0222222222222	JUN/PLCG2/NFKBIA	5.81291632807977
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/18	138/9376	11.3236714975845	FN1/JUN/NFKBIA	5.35815300881718
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/18	300/9376	6.94518518518518	NR4A1/JUN/GADD45B/JUND	4.58996253819991
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/18	50/9376	20.8355555555556	AMD1/OAT	6.1675408640644
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/18	174/9376	8.9808429118774	DNAJA1/DNAJB1/HSP90AA1	4.6602867791873
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/18	187/9376	8.35650623885918	JUN/NFKBIA/HSP90AA1	4.45644607209683
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/18	196/9376	7.97278911564626	JUN/PLCG2/NFKBIA	4.32656861966231
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/18	214/9376	7.30218068535826	JUN/PLCG2/NFKBIA	4.09009093367373
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/18	73/9376	14.2709284627093	GADD45B/PLCG2	4.99208070741615
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/18	76/9376	13.7076023391813	GADD45B/PLCG2	4.87819670047118
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/18	77/9376	13.5295815295815	GADD45B/NFKBIA	4.84165874155683
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	3/18	233/9376	6.70672389127325	FN1/TTN/SPTAN1	3.86857331271233
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/18	78/9376	13.3561253561254	JUN/NFKBIA	4.80579461483178
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/18	238/9376	6.56582633053221	JUN/PLCG2/NFKBIA	3.81437092199281
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/18	82/9376	12.7046070460705	HSPA2/HSP90AA1	4.6686659468467
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	3/18	248/9376	6.3010752688172	JUN/NFKBIA/HSP90AA1	3.71049940048427
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/18	86/9376	12.1136950904393	JUN/PLCG2	4.54077744430173
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	3/18	253/9376	6.17654808959157	JUN/PLCG2/NFKBIA	3.66068235931788
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/18	87/9376	11.9744572158365	JUN/GADD45B	4.51012485699975
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/18	90/9376	11.5753086419753	JUN/NFKBIA	4.42109998290426
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/18	93/9376	11.2019115890084	JUN/NFKBIA	4.33619919959933
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/18	103/9376	10.1143473570658	JUN/NFKBIA	4.07910071836379
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/18	106/9376	9.82809224318658	NFKBIA/HSP90AA1	4.00876223343585
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/18	109/9376	9.55759429153925	JUN/NFKBIA	3.94117510531395
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/18	119/9376	8.75443510737628	JUN/NFKBIA	3.73352346430917
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/18	122/9376	8.53916211293261	JUN/NFKBIA	3.67594174333576
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/18	130/9376	8.01367521367521	JUN/NFKBIA	3.53159385775145
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/18	136/9376	7.66013071895425	JUN/NFKBIA	3.43120441531981
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/18	139/9376	7.49480415667466	JUN/HSP90AA1	3.3832832496614
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	2/18	142/9376	7.33646322378717	JUN/HSP90AA1	3.3367719498943
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	3/18	362/9376	4.31675874769797	NR4A1/FN1/HSP90AA1	2.82253776852665
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/18	148/9376	7.03903903903904	JUN/GADD45B	3.2476952654421
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/18	163/9376	6.39127471029312	JUN/NFKBIA	3.04519493410005
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/18	170/9376	6.1281045751634	GADD45B/PLCG2	2.95921294900741
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/18	173/9376	6.0218368657675	DNAJB1/NFKBIA	2.92382457077963
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/18	193/9376	5.39781232009211	PLCG2/NFKBIA	2.7074062319836
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/18	28/9376	18.6031746031746	DHFR	4.09110881355463
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	2/18	200/9376	5.20888888888889	JUN/NFKBIA	2.63867636228881
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/18	30/9376	17.362962962963	DHFR	3.93677012872706
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	2/18	203/9376	5.13191023535851	FN1/JUN	2.61019870907554
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	2/18	204/9376	5.10675381263617	FN1/PLCG2	2.60083080250109
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/18	205/9376	5.08184281842818	JUN/NFKBIA	2.59152397646973
NA	NA	hsa04981	Folate transport and metabolism	1/18	31/9376	16.8028673835125	DHFR	3.86507085556577
Human Diseases	Immune disease	hsa05310	Asthma	1/18	32/9376	16.2777777777778	PRG2	3.79663750268213
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/18	217/9376	4.80081925243216	JUN/HSP90AA1	2.48435368937941
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	2/18	224/9376	4.65079365079365	JUN/NFKBIA	2.42540160334308
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/18	226/9376	4.60963618485742	JUN/NFKBIA	2.40900374111054
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/18	37/9376	14.0780780780781	GADD45B	3.4956260771211
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	2/18	227/9376	4.58932941752325	JUN/NFKBIA	2.40087640472486
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/18	39/9376	13.3561253561254	DHFR	3.39110549125328
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/18	49/9376	10.6303854875283	JUN	2.96415625368677
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/18	51/9376	10.2135076252723	PLCG2	2.89345037152058
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/18	54/9376	9.64609053497942	AMD1	2.79442513983228
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/18	56/9376	9.3015873015873	NFKBIA	2.73260945736244
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/18	59/9376	8.8286252354049	GADD45B	2.64547603592775
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/18	60/9376	8.68148148148148	PLCG2	2.61779867455285
NA	NA	hsa04517	IgSF CAM signaling	2/18	299/9376	3.4842066146414	PLCG2/SPTAN1	1.9146196445963
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/18	63/9376	8.26807760141093	GADD45B	2.53848966272865
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/18	65/9376	8.01367521367521	NR4A1	2.48848218626521
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/18	66/9376	7.89225589225589	JUN	2.46427341006023
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/18	69/9376	7.54911433172303	PLCG2	2.39459808559762
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/18	69/9376	7.54911433172303	JUN	2.39459808559762
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/18	70/9376	7.44126984126984	NFKBIA	2.37229863780364
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/18	70/9376	7.44126984126984	JUN	2.37229863780364
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/18	72/9376	7.23456790123457	NFKBIA	2.32899269804634
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/18	73/9376	7.13546423135464	GADD45B	2.30795702851181
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/18	75/9376	6.94518518518518	GADD45B	2.26705244350349
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/18	77/9376	6.76479076479076	GADD45B	2.22762025481049
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/18	78/9376	6.67806267806268	PLCG2	2.20842717716388
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/18	78/9376	6.67806267806268	FN1	2.20842717716388
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/18	78/9376	6.67806267806268	JUN	2.20842717716388
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/18	80/9376	6.51111111111111	PLCG2	2.17103324248473
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/18	83/9376	6.27576974564926	NFKBIA	2.1172750557198
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/18	88/9376	5.91919191919192	SERPINE2	2.03331361953306
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/18	89/9376	5.85268414481898	FN1	2.01729622312989
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/18	93/9376	5.60095579450418	JUN	1.95558064382914
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/18	95/9376	5.48304093567251	JUN	1.92604970728228
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/18	98/9376	5.31519274376417	PLCG2	1.88328662855059
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/18	98/9376	5.31519274376417	PLCG2	1.88328662855059
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/18	98/9376	5.31519274376417	NR4A1	1.88328662855059
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/18	99/9376	5.26150392817059	JUN	1.86942085119753
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/18	99/9376	5.26150392817059	PLCG2	1.86942085119753
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/18	99/9376	5.26150392817059	JUN	1.86942085119753
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/18	99/9376	5.26150392817059	TTN	1.86942085119753
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/18	103/9376	5.0571736785329	FN1	1.81577675485457
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/18	105/9376	4.96084656084656	JUN	1.78998646852395
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/18	105/9376	4.96084656084656	TTN	1.78998646852395
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/18	109/9376	4.77879714576962	NFKBIA	1.74031401017258
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/18	110/9376	4.73535353535354	PLCG2	1.728272729294
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/18	110/9376	4.73535353535354	HSP90AA1	1.728272729294
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/18	112/9376	4.65079365079365	NFKBIA	1.70461927542078
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/18	115/9376	4.52946859903382	JUND	1.67016612469512
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/18	116/9376	4.4904214559387	PLCG2	1.65894405799721
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/18	122/9376	4.2695810564663	PLCG2	1.59418106530265
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/18	122/9376	4.2695810564663	PLCG2	1.59418106530265
Organismal Systems	Immune system	hsa04611	Platelet activation	1/18	126/9376	4.13403880070547	PLCG2	1.55327783657396
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/18	133/9376	3.91645781119465	GADD45B	1.48561204770552
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/18	133/9376	3.91645781119465	PLCG2	1.48561204770552
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/18	144/9376	3.61728395061728	NFKBIA	1.38808020371
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/18	149/9376	3.49589858314691	PLCG2	1.34685294033113
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/18	150/9376	3.47259259259259	GADD45B	1.33881891212657
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/18	154/9376	3.38239538239538	DHFR	1.30735041911763
NA	NA	hsa04518	Integrin signaling	1/18	154/9376	3.38239538239538	FN1	1.30735041911763
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/18	154/9376	3.38239538239538	JUN	1.30735041911763
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/18	155/9376	3.36057347670251	NR4A1	1.29964497363428
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/18	156/9376	3.33903133903134	NFKBIA	1.2920021894637
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/18	157/9376	3.31776362349611	GADD45B	1.28442110040026
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/18	157/9376	3.31776362349611	JUN	1.28442110040026
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/18	158/9376	3.29676511954993	GADD45B	1.27690076134711
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/18	168/9376	3.1005291005291	HSP90AA1	1.20484466363026
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/18	170/9376	3.0640522875817	JUN	1.19107755454568
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/18	178/9376	2.92634207240949	JUN	1.1379602154656
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/18	180/9376	2.89382716049383	NFKBIA	1.12514237749122
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/18	184/9376	2.83091787439613	PLCG2	1.10002647699661
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/18	195/9376	2.67122507122507	PLCG2	1.03427880383172
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	1/18	201/9376	2.59148700939746	GADD45B	1.00029583518994
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	1/18	227/9376	2.29466470876162	NFKBIA	0.865991830150996
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/18	232/9376	2.24521072796935	FN1	0.842265685749062
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/18	238/9376	2.18860877684407	PLCG2	0.814577115198262
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/18	254/9376	2.05074365704287	PLCG2	0.744558749823463
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	1/18	323/9376	1.61265909872721	PLCG2	0.491421619694135
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	1/18	333/9376	1.56423089756423	FN1	0.459783187034956
NA	NA	hsa04519	Cadherin signaling	1/18	404/9376	1.28932893289329	NFKBIA	0.260716360965496