category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/418	78/9376	3.7384370015949	FN1/CAV1/ARPC1B/CAV2/ITGA5/ACTB/CLTB/MAD2L2/ACTG1/SEPTIN3/DNM2/ITGB1/ARPC1A	5.24594260559831
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/418	180/9376	2.61690590111643	B2M/HLA-G/BST2/IFNGR2/TAP1/TAP2/NECTIN2/TAPBP/HLA-C/HLA-E/ITGA5/IRF9/TAPBPL/OAS2/RHEB/OAS3/EIF4EBP1/OAS1/STAT1/SP100/EIF2AK2	4.73140110909134
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	21/418	205/9376	2.29777103512662	B2M/HLA-G/ISG15/TAP1/TAP2/TAPBP/CCNE1/HLA-C/HLA-E/IRF9/TAPBPL/OAS2/OAS3/OAS1/LYN/STAT1/ENTPD8/ENTPD1/CD40/EIF2AK2/CDK4	4.05821368245042
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/418	233/9376	2.1179128077705	BGN/FN1/HSPG2/ATP1A4/FBLN1/ITGA1/DCN/CSRP2/SGCB/ITGA5/FBLN2/COL27A1/ACTB/TPM2/TNNI2/FHL2/COL5A1/SYNE1/SDC3/ACTG1/ITGB1/SYNE3	3.73258565359863
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/418	160/9376	2.38325358851675	HLA-G/CLDN19/PVR/NECTIN2/NLGN4X/PTPRF/PDCD1LG2/HLA-C/HLA-E/MAG/CD276/SDC3/ESAM/CD22/CD40/CLDN8/ITGB1	3.8120519796911
NA	NA	hsa03272	Virion - Hepatitis viruses	8/418	48/9376	3.7384370015949	CLDN19/CD9/HSPG2/CD81/CD63/LAMP1/SCARB1/CLDN8	4.10863304085784
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/418	49/9376	3.66214236890929	PLOD3/GALNT2/GALNT6/COLGALT1/GALNT7/B4GALT2/GALNT3/GALNT12	4.03577159298146
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/418	85/9376	2.90278637770898	APRT/TYMP/AK5/CDA/CMPK1/ENTPD8/GUK1/CMPK2/IMPDH1/ENTPD1/NT5E	3.80659362937376
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/418	61/9376	3.30943603419876	FTL/ATP1A4/MT1X/MT1E/MT1F/CYBRD1/HMOX1/STEAP1/MT1G	3.90883803684476
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/418	155/9376	2.3154190461491	HLA-G/TAP1/TAP2/ATP6V0E1/TUBB2A/HLA-C/HLA-E/ITGA5/ACTB/LAMP1/TUBB6/ACTG1/SCARB1/CD36/MRC2/ITGB1	3.56705013899917
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	22/418	250/9376	1.97389473684211	CTSH/NPC2/SLC15A3/CTSA/ATP6V0E1/HEXB/AP3S1/AGA/CTSZ/LAPTM4B/CD63/LAPTM4A/FUCA1/CLTB/LAMP1/CLN5/FUCA2/ARSA/CTSF/AP1S1/NAGLU/LAMTOR1	3.3713981251115
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/418	82/9376	2.73544170848407	B2M/HLA-G/TAP1/TAP2/TAPBP/IFI30/HLA-C/HLA-E/TAPBPL/NFYB	3.40944644450168
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	18/418	200/9376	2.01875598086124	TNFSF10/CLDN19/IL1R1/TUBB2A/ARPC1B/LPAR2/ACTB/MAPK3/WIPF1/TUBB6/TMED10/MYO1B/BRK1/ACTG1/CLDN8/ARF1/ITGB1/ARPC1A	3.14576819197922
NA	NA	hsa04518	Integrin signaling	15/418	154/9376	2.18480084508793	FN1/FLT1/ITGA1/ERBB2/ITGA5/PARVA/LAMA3/ACTB/FLNA/LIMS2/ITGAD/LAMA4/ACTG1/VWF/ITGB1	3.20229551274472
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/418	15/9376	5.98149920255183	HEXB/ST8SIA1/ST6GALNAC6/ST3GAL5	4.17073716591494
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/418	59/9376	3.04144027248398	TYMP/CDA/CMPK1/ENTPD8/CMPK2/ENTPD1/NT5E/NUDT2	3.39776146178544
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/418	36/9376	3.7384370015949	B3GNT3/GALNT2/GALNT6/GALNT7/GALNT3/GALNT12	3.55589408443742
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/418	227/9376	1.87745294353224	B2M/HLA-G/IL1R1/TAP1/TAP2/TAPBP/GNGT1/HLA-C/PTK2B/HLA-E/GNG4/TAPBPL/MAPK3/RHEB/EIF4EBP1/PTGER3/CCR1/GNG10/CDK4	2.89080102504317
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/418	38/9376	3.54167715940569	HEXB/GNPDA2/GALK1/UXS1/PGM1/GNPDA1	3.39120075097159
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/418	50/9376	3.14028708133971	AOC1/PYCR1/P4HA2/MAOA/SRM/NOS2/ODC1	3.27776321304923
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/418	18/9376	4.9845826687932	HEXB/AGA/FUCA1/FUCA2	3.65507105230795
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/418	52/9376	3.01950680898049	NPC2/TSPO/LPL/ANGPTL4/SCARB1/CD36/SOAT1	3.15438073160296
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/418	93/9376	2.41189483973864	NECTIN2/PTPRF/FGFR1/ERBB2/ACTB/SMAD3/MAPK3/HEG1/ACTG1/SNAI1	2.95575137325781
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/418	203/9376	1.87842647370778	FN1/CAV1/FLT1/CAV2/ITGA1/ERBB2/ITGA5/PARVA/LAMA3/ACTB/FLNA/MAPK3/VASP/LAMA4/ACTG1/VWF/ITGB1	2.73316586531889
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	17/418	204/9376	1.86921850079745	FN1/HSPG2/CAV1/LUM/CAV2/FGFR1/ERBB2/DCN/CD63/ITGA5/ACTB/FLNA/MAPK3/ACTG1/TIMP3/TWIST2/ITGB1	2.71131684425979
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/418	42/9376	3.20437457279563	FTL/ACSL5/HMOX1/SLC39A8/GPX4/SLC39A14	3.09274696797395
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/418	70/9376	2.5634996582365	HLA-G/CAV1/HLA-C/HLA-E/SGCB/ACTB/ACTG1/CD40	2.83617834400056
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/418	44/9376	3.0587211831231	HEXB/TUSC3/MGAT2/B4GALT2/MGAT4A/MGAT1	2.95668294663918
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	22/418	298/9376	1.65595196043801	TNFSF10/EBI3/IL2RB/IFNGR2/CSF2RB/IL1R1/ACKR3/GDF15/IL1R2/IL17RE/IL6ST/EPOR/IL1RAP/ACVRL1/CCR1/IL17D/INHA/BMP5/CD40/CSF1R/XCR1/IL13RA1	2.48572641383767
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/418	232/9376	1.7403068800528	FN1/ARPC1B/FGFR1/ITGA1/ITGA5/LPAR2/ACTB/MAPK3/ITGAD/C7/BRK1/ACTG1/PFN1/CFL2/ITGB1/FGF1/ARPC1A/ARHGEF4	2.46635688234982
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/418	88/9376	2.29404088734232	SERPINE2/C2/PROCR/CFB/SERPING1/C7/CFD/VWF/SERPINE1	2.63448955791029
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/418	89/9376	2.26826514703511	FN1/HSPG2/ITGA1/ITGA5/LAMA3/LAMA4/CD36/VWF/ITGB1	2.59678257591431
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	12/418	138/9376	1.95048887039734	FN1/ARPC1B/PKN1/PTK2B/ITGA5/ACTB/MAPK3/WIPF1/RPS6KA1/ACTG1/ITGB1/ARPC1A	2.42977383025264
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/418	156/9376	1.86921850079745	CLDN19/MX1/CD81/IRF9/OAS2/MAPK3/OAS3/OAS1/STAT1/SCARB1/CLDN8/EIF2AK2/CDK4	2.36479800388756
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/418	14/9376	4.80656185919344	B3GNT7/B4GALT2/B4GALT4	3.07879548668941
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/418	333/9376	1.54926218084113	HLA-G/FN1/ISG15/MX1/ATP6V0E1/CCNE1/ITGA1/HLA-C/HLA-E/ITGA5/IRF9/HES4/LAMA3/MAPK3/RHEB/EIF4EBP1/STAT1/LAMA4/NOTCH2/VWF/ITGB1/EIF2AK2/CDK4	2.20451875676911
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/418	110/9376	2.0391474554154	IFNGR2/EGLN3/FLT1/ERBB2/LDHA/MAPK3/EIF4EBP1/HMOX1/NOS2/SERPINE1	2.36807592816978
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/418	51/9376	2.63889670700816	PLA2G7/PLPP2/LPCAT4/LPCAT1/LPCAT2/GDPD3	2.53501480742735
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/418	51/9376	2.63889670700816	KDELR3/ATP6V0E1/ACTB/KDELR1/ACTG1/ARF1	2.53501480742735
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/418	128/9376	1.92763157894737	APRT/PAPSS1/AK5/PDE6H/ENTPD8/GUK1/IMPDH1/ENTPD1/NT5E/PGM1/NUDT2	2.28257391047922
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	16/418	214/9376	1.67705585118276	B2M/HLA-G/BST2/TAP1/TAP2/TAPBP/GNGT1/HLA-C/PTK2B/HLA-E/GNG4/TAPBPL/MAPK3/GNG10/CFL2/AP1S1	2.16423536117841
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/418	98/9376	2.05995508251147	PLPP2/ARPC1B/ASAP3/MAPK3/VASP/LYN/DNM2/CFL2/ARPC1A	2.27846082265184
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	18/418	250/9376	1.615004784689	HLA-G/IL2RB/CAV1/ARPC1B/ASAP3/CAV2/HLA-C/HLA-E/CLTB/SMAD3/MVB12A/WIPF1/ARAP2/DNM2/ARF5/ARF4/ARF1/ARPC1A	2.12900419275111
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/418	362/9376	1.48711306140791	FN1/IL2RB/FLT1/CCNE1/GNGT1/FGFR1/ITGA1/ERBB2/PKN1/ITGA5/LPAR2/LAMA3/GNG4/EPOR/MAPK3/RHEB/EIF4EBP1/GNG10/LAMA4/VWF/CSF1R/ITGB1/FGF1/CDK4	2.04170754313554
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/418	100/9376	2.01875598086124	CD9/IL1R1/ITGA1/IL1R2/ITGA5/EPOR/CD36/CD22/CSF1R	2.21237148081187
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/418	28/9376	3.20437457279563	B3GNT3/B4GALT2/ST8SIA1/B4GALT4	2.52332567498991
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/418	41/9376	2.73544170848407	PIPOX/AGXT/PHGDH/GCSH/MAOA	2.40554257658297
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/418	56/9376	2.40328092959672	MGAT5/TUSC3/MGAT2/B4GALT2/MGAT4A/MGAT1	2.27509182863764
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/418	103/9376	1.95995726297208	FN1/IL1R1/SERPINB6/IL1R2/LAMA3/PRDX1/HSPB1/LAMA4/NOS2	2.11606318421263
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/418	170/9376	1.71528285955531	CLDN19/ARPC1B/PRKAG2/ERBB2/CGNL1/ACTB/VASP/RAB8B/ACTG1/CLDN8/ITGB1/ARPC1A/CDK4	2.03298906907183
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/418	224/9376	1.60218728639781	B2M/HLA-G/IL2RB/TSPO/IL1R1/CCNE1/ANAPC13/HLA-C/IL1R2/HLA-E/SMAD3/MAPK3/MSX1/NFYB/CD40/CDK4	1.97045189019713
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	13/418	173/9376	1.68553807008325	TNFSF10/IFNGR2/MX1/IRF9/ACTB/OAS2/MAPK3/OAS3/OAS1/STAT1/ACTG1/EIF2AK2/CDK4	1.96588526779862
NA	NA	hsa04517	IgSF CAM signaling	20/418	299/9376	1.5003760541518	PVR/NECTIN2/NLGN4X/PTPRF/TUBB2A/SLIT2/ARPC1B/FGFR1/MAG/ITGA5/ACTB/MAPK3/TUBB6/IL1RAP/ESAM/LYN/ACTG1/ITGB1/DYNLL1/ARPC1A	1.89945581080526
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/418	59/9376	2.28108020436299	GPX3/PRDX6/SRM/GPX4/GPX8/ODC1	2.13222253254776
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	13/418	174/9376	1.67585106968047	SSR2/TXNDC5/SSR3/TUSC3/FBXO2/FBXO6/OS9/HERPUD1/CKAP4/CRYAB/SAR1A/P4HB/XBP1	1.94380531460058
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	17/418	248/9376	1.53758296033338	TNFSF10/TUBB2A/ARPC1B/PKN1/ACTB/FLNA/MAPK3/TUBB6/TXN/BRK1/ACTG1/DYNLT1/PFN1/DNM2/ARF1/DYNLL1/ARPC1A	1.85332579015462
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/418	76/9376	2.06597834298665	LPL/ACSL5/FABP7/ANGPTL4/CD36/FABP5/PLIN2	2.01549605906676
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/418	109/9376	1.85206970721215	EBI3/IL2RB/IFNGR2/IL1R1/IL6ST/SMAD3/MAPK3/IL1RAP/STAT1	1.93280056116549
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/418	196/9376	1.60218728639781	HLA-G/GNGT1/HLA-C/HLA-E/IRF9/IL6ST/GNG4/MAPK3/LYN/CCR1/STAT1/GNG10/EIF2AK2/CDK4	1.84037585728124
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/418	78/9376	2.01300453932033	C2/ITGA5/MAPK3/SERPING1/NOS2/CFL2/ITGB1	1.94058277381951
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/418	112/9376	1.80246069719754	IFNGR2/LAMA3/MAPK3/PPIF/STAT1/LAMA4/NOS2/CD40/ITGB1	1.84544777293994
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	16/418	238/9376	1.50794097543324	ISG15/MX1/C2/CFB/IRF9/IL6ST/OAS2/MAPK3/OAS3/OAS1/C7/STAT1/CFD/VWF/RPL10/EIF2AK2	1.71452728289278
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/418	99/9376	1.8125755159248	PRKAG2/ITGA1/SGCB/ITGA5/ACTB/TPM2/ACTG1/ITGB1	1.75568177649957
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/418	83/9376	1.89173920562633	PIPOX/AGXT/ACSL5/FAR2/PRDX1/PHYH/NOS2	1.76265447788938
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/418	23/9376	2.92573330559601	PRCP/CTSA/ATP6AP2	1.99734387662831
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/418	37/9376	2.42493210914264	GALK1/UXS1/PGM1/NANS	1.87591474591663
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/418	136/9376	1.6493104418801	IL2RB/MX1/CCNE1/IRF9/OAS2/OAS3/OAS1/STAT1/EIF2AK2/CDK4	1.64760881043466
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/418	38/9376	2.36111810627046	TAP1/TAP2/ORAI1/CD40	1.81605469721604
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/418	212/9376	1.48126749119798	FLT1/FGFR1/LPAR2/ACTB/MAPK3/VASP/RALB/ACTG1/PFN1/APBB1IP/CSF1R/ITGB1/RGS14/FGF1	1.5310175430298
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/418	39/9376	2.30057661636609	HLA-G/HLA-C/HLA-E/CD40	1.75805644859255
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/418	122/9376	1.65471801709938	ATP1A4/DIO2/ACTB/PLCD3/MAPK3/RHEB/STAT1/ACTG1/NOTCH2	1.5723083114352
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/418	142/9376	1.57962126827953	IL1R1/CAV1/CAV2/IL1R2/ACTB/TXN/HMOX1/SUMO2/ACTG1/SUMO1	1.50335587788607
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/418	41/9376	2.18835336678726	ERBB2/TYMP/MAPK3/CDK4	1.6472086650087
Organismal Systems	Immune system	hsa04611	Platelet activation	9/418	126/9376	1.60218728639781	ACTB/MAPK3/VASP/LYN/ORAI1/ACTG1/VWF/APBB1IP/ITGB1	1.46998951988694
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/418	93/9376	1.68832638781705	FN1/CCNE1/LAMA3/LAMA4/NOS2/ITGB1/CDK4	1.44098668596058
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/418	77/9376	1.74784067607034	ERBB2/SMAD3/MAPK3/STAT1/RALB/CDK4	1.42332662064166
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/418	45/9376	1.99383306751728	TAP1/TAP2/ABCA7/ABCC9	1.44352348866837
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/418	15/9376	2.99074960127592	AK5/ALPL	1.66674589565699
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/418	116/9376	1.54693944893582	CLDN19/PTK2B/ACTB/VASP/ESAM/ACTG1/CLDN8/ITGB1	1.28035676365303
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/418	63/9376	1.78020809599757	PLOD3/PIPOX/COLGALT1/SMYD3/PLOD1	1.34215964246595
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/418	194/9376	1.3874611552311	TUBB2A/ACTB/TPM2/TNNI2/MYO7B/TUBB6/KIF12/MYO1B/ACTG1/DYNLT1/DYNLL1/KIF21A	1.17795483683732
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/418	137/9376	1.47354451157755	TNFSF10/CTSH/CSF2RB/ENDOG/CTSZ/ACTB/MAPK3/ACTG1/CTSF	1.20608205992548
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/418	16/9376	2.80382775119617	HEXB/ST8SIA1	1.55985913665022
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/418	100/9376	1.57014354066986	TNFSF10/IL2RB/ACKR3/IL6ST/CCR1/CSF1R/XCR1	1.23814665439387
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/418	157/9376	1.42870203882608	HLA-G/CCNE1/HLA-C/HLA-E/SMAD3/MAPK3/RHEB/EIF4EBP1/SERPINE1/CDK4	1.17012354355536
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/418	65/9376	1.72543246227457	CYP11A1/POMC/HSD3B1/ORAI1/SCARB1	1.26772119366872
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/418	101/9376	1.55459756501966	FN1/SMAD3/PLCD3/MAPK3/STAT1/SERPINE1/CDK4	1.21045858860577
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/418	32/9376	2.10287081339713	B4GALT2/GALK1/PGM1	1.34989959773414
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/418	140/9376	1.44196855775803	CCN2/GNGT1/PRKAG2/GNG4/SMAD3/MAPK3/GNG10/NOS2/SERPINE1	1.1381032929048
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/418	103/9376	1.52441120453384	PRCP/ATP1A4/COL17A1/COL16A1/COL27A1/COL5A1/COL12A1	1.15597567319508
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/418	86/9376	1.5649271169467	ITGA1/SGCB/ITGA5/ACTB/ACTG1/ITGB1	1.13684705313615
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/418	105/9376	1.49537480063796	ITGA1/SGCB/ITGA5/ACTB/TPM2/ACTG1/ITGB1	1.10263943241726
NA	NA	hsa04519	Cadherin signaling	22/418	404/9376	1.22146951537259	LHFPL6/KRT10/ARPC1B/TEAD2/FAT2/KRT19/FGFR1/ERBB2/PTK2B/TMC6/KRT7/ACTB/MAPK3/VASP/MYO1B/BRK1/ACTG1/WWTR1/CTNND2/PCDH10/ARPC1A/PKP1	0.982942821742711
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/418	19/9376	2.36111810627046	HEXB/NAGLU	1.28284015912968
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/418	71/9376	1.57962126827953	SLC16A3/FGFR1/ERBB2/LDHA/MAPK3	1.05896973549028
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/418	53/9376	1.69287713279769	ATP1A4/CLTB/PTH1R/DNM2	1.0926588084665
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/418	54/9376	1.6615275562644	HLA-G/HLA-C/HLA-E/CD40	1.05307310275296
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/418	38/9376	1.77083857970285	ATP1A4/MAPK3/SFN	1.02848167033826
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/418	21/9376	2.13624971519708	CSGALNACT1/CHST15	1.12597769860412
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/418	75/9376	1.49537480063796	CCNE1/SFN/SERPINE1/SHISA5/CDK4	0.930396290320545
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	14/418	254/9376	1.23633349659044	FLT1/FGFR1/ERBB2/PTK2B/PLCD3/EDNRB/PTGER3/PPIF/CASQ1/MST1/NOS2/ORAI1/FGF1/GRIN2D	0.824831721695659
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/418	22/9376	2.0391474554154	AOC1/MAOA	1.05404241199805
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/418	157/9376	1.28583183494347	CCN2/TEAD2/ACTB/SMAD3/ACTG1/WWTR1/SERPINE1/BMP5/FGF1	0.780165544537263
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/418	78/9376	1.43786038522881	IFNGR2/MAPK3/STAT1/NOS2/ITGB1	0.838796163226574
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/418	98/9376	1.37330338834098	ATP1A4/CYP11A1/POMC/HSD3B1/ORAI1/SCARB1	0.802446404882356
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/418	201/9376	1.22754647813564	ASPSCR1/IL2RB/HPGD/FLT1/IL1R2/CEBPB/NUPR1/CD40/CSF1R/MYCN/ARNT2	0.704422728724577
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/418	43/9376	1.5649271169467	PLPP2/SCARB1/CD36	0.80201827920513
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/418	205/9376	1.20359435173299	HLA-G/CCNE1/HLA-C/HLA-E/IRF9/IL6ST/MAPK3/LYN/SP100/EIF2AK2/CDK4	0.636652661763125
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/418	63/9376	1.42416647679806	HPGD/PTGDS/PTGES/GPX4	0.729676005370616
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/418	44/9376	1.52936059156155	HLA-G/HLA-C/HLA-E	0.760254203688966
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/418	187/9376	1.19949850318553	PKN1/IRF9/OAS2/MAPK3/GBP3/RBCK1/OAS3/TXN/OAS1/STAT1	0.595243373166424
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/418	45/9376	1.49537480063796	HLA-G/HLA-C/HLA-E	0.719522406516096
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/418	65/9376	1.38034596981965	PLPP2/LPL/GPAT2/AKR1A1	0.664669244818496
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/418	46/9376	1.462866652798	PSMB8/PSMB9/POMP	0.679770380432609
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/418	253/9376	1.15256160523479	IL1R1/ARPC1B/ITGA5/ACTB/PLCD3/MAPK3/RBCK1/ACTG1/SEPTIN3/PFN1/ARF1/ITGB1/ARPC1A	0.531379655416381
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/418	149/9376	1.20432869850037	PLPP2/PTK2B/LPAR2/MAPK3/RHEB/RALB/DNM2/ARF1	0.543075852543253
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/418	28/9376	1.60218728639781	DHFR/ALPL	0.689317804547631
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/418	10/9376	2.24306220095694	PAPSS1	0.849540394740748
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/418	110/9376	1.22348847324924	NOG/LRRC32/DCN/SMAD3/MAPK3/BMP5	0.509299879402945
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/418	29/9376	1.54693944893582	TEAD2/WWTR1	0.63719209068616
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/418	70/9376	1.28174982911825	PRKAG2/POMC/ACSL5/CD36	0.511092381479859
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	8/418	154/9376	1.16522711738023	DHFR/NAPRT/VKORC1/AK5/AKR1A1/CMPK1/CMPK2/ALPL	0.446578054669754
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/418	133/9376	1.18055905313523	TNFSF10/HLA-G/IFNGR2/HLA-C/PTK2B/HLA-E/MAPK3	0.453009033700115
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/418	91/9376	1.23245175876755	CD81/MAPK3/IFITM1/LYN/CD22	0.481316587174057
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/418	50/9376	1.34583732057416	CD81/CD36/CD40	0.529635887148347
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/418	155/9376	1.15770952307455	CYP11A1/CCNE1/POMC/MAPK3/HSD3B1/ORAI1/SCARB1/CDK4	0.427664308078445
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/418	93/9376	1.20594741986932	IL2RB/IFNGR2/MAPK3/STAT1/NOTCH2	0.431143561095763
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/418	31/9376	1.44713690384319	AGXT/GCSH	0.538641684146941
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/418	31/9376	1.44713690384319	SPCS2/SEC11A	0.538641684146941
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/418	52/9376	1.29407434670593	CYP11A1/HSD3B1/SCARB1	0.459331183625072
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/418	73/9376	1.22907517860654	FGFR1/MAPK3/FGF1/CDK4	0.424420354196429
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/418	116/9376	1.16020458670186	GNGT1/GNG4/MAPK3/HOMER3/GNG10/GRIN2D	0.37503059351647
Human Diseases	Immune disease	hsa05310	Asthma	2/418	32/9376	1.40191387559809	PRG2/CD40	0.491937380519165
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/418	12/9376	1.86921850079745	VKORC1	0.650814367580091
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/418	54/9376	1.2461456671983	PHGDH/LDHA/SRM	0.391834594086219
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/418	97/9376	1.15621762935925	GNGT1/GNG4/MAPK3/GNG10/GRIN2D	0.33406699674749
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/418	184/9376	1.0971499895985	SEMA5A/SLIT2/RHOD/MAPK3/EFNB1/EPHB2/PLXNB2/CFL2/ITGB1	0.287484816335114
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/418	55/9376	1.22348847324924	PLPP2/HEXB/ARSA	0.359065326815176
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/418	142/9376	1.10573488779567	IFNGR2/IL1R1/IRF9/FHL2/MAPK3/STAT1/CSF1R	0.2742431545638
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/418	99/9376	1.132859697453	C2/KRT10/KRT19/CFB/CFD	0.287061750050397
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	14/418	300/9376	1.04676236044657	IL1R1/MAPK8IP2/FLT1/FGFR1/ERBB2/RASGRF2/FLNA/MAPK3/HSPB1/STMN1/IL1RAP/RPS6KA1/CSF1R/FGF1	0.177818957151167
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/418	79/9376	1.13572769668706	SLC6A2/ATP6V0E1/CLTB/DNM2	0.261685018134942
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/418	168/9376	1.06812485759854	TNFSF10/IFNGR2/FTL/IRF9/RBCK1/PPIA/STAT1/EIF2AK2	0.192462376040214
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/418	168/9376	1.06812485759854	IL2RB/IFNGR2/CSF2RB/IRF9/IL6ST/EPOR/STAT1/IL13RA1	0.192462376040214
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/418	36/9376	1.2461456671983	DCXR/AKR1A1	0.31962317241206
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/418	193/9376	1.04598755485039	GNGT1/PTK2B/GNG4/MAPK3/LYN/CCR1/STAT1/GNG10/XCR1	0.139442426400648
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/418	37/9376	1.21246605457132	AGXT/RIMKLA	0.279710311964881
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/418	104/9376	1.0783952889216	PLPP2/GPAT2/LPCAT4/LPCAT1/LPCAT2	0.17365535222451
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/418	82/9376	1.09417668339363	TYMP/CDA/CMPK1/IMPDH1	0.185019385428879
NA	NA	hsa04382	Cornified envelope formation	10/418	217/9376	1.03366921703085	CLDN19/KRT10/COL17A1/KRT19/S100A4/LAMA3/KRT7/PCSK6/CLDN8/PKP1	0.108394464593088
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/418	105/9376	1.06812485759854	IRF9/MAPK3/STAT1/IL17D/BCL3	0.151637011449158
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/418	38/9376	1.18055905313523	NAPRT/NT5E	0.240908643460481
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/418	106/9376	1.05804820799856	CCNE1/FGFR1/ERBB2/IL1R2/MAPK3	0.129828527918532
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/418	16/9376	1.40191387559809	MAOA	0.347554820898192
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/418	39/9376	1.15028830818305	DHFR/GCSH	0.203152452554087
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/418	130/9376	1.03525947736474	GNGT1/GNG4/MAPK3/EDNRB/GNG10/NOS2	0.087445779268122
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/418	62/9376	1.08535267788239	PRKAG2/EIF4EBP2/CRYAB	0.145650885510781
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/418	62/9376	1.08535267788239	DTX3L/NOTCH2/TLE6	0.145650885510781
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	12/418	268/9376	1.0043562093837	TUBB2A/UBE2L6/SLC39A6/COX7A2L/TUBB6/TXN/MAOA/PPIF/SLC39A8/SLC39A14/COX7B2/XBP1	0.0156290608579018
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/418	17/9376	1.31944835350408	PAPSS1	0.284759775007933
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/418	17/9376	1.31944835350408	LAMP1	0.284759775007933
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/418	87/9376	1.03129296595721	ATP1A4/TPM2/COX7A2L/COX7B2	0.0633417594392623
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/418	133/9376	1.0119077598302	TNFSF10/PRKAG2/SMAD3/MAPK3/HOMER3/FBXO32	0.0298756704831118
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/418	157/9376	1.00009142717825	EPOR/CEBPB/MAPK3/CD36/ODC1/ANO9/ATP11A	0.000249546501078021
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/418	18/9376	1.2461456671983	ACSL5	0.225790246460118
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/418	18/9376	1.2461456671983	PRDX1	0.225790246460118
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/418	181/9376	0.991408707605276	IFNGR2/LAMP1/CEBPB/MAPK3/STAT1/NFYB/NOS2/MRC2	-0.0252110057047709
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/418	158/9376	0.993761734601175	CCNE1/ANAPC13/CDKN1C/SMAD3/MAD2L2/SFN/CDK4	-0.0170821404731628
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/418	42/9376	1.06812485759854	AOC1/MAOA	0.0955794670205903
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/418	66/9376	1.0195737277077	IFNGR2/SMAD3/STAT1	0.0344698124022309
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/418	67/9376	1.0043562093837	LDHA/AKR1A1/PGM1	0.007729704338068
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/418	67/9376	1.0043562093837	MAPK3/RPS6KA1/GRIN2D	0.007729704338068
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/418	19/9376	1.18055905313523	GCSH	0.170175096039959
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/418	115/9376	0.975244435198669	GNGT1/GNG4/MAPK3/MAOA/GNG10	-0.0576980409209367
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/418	115/9376	0.975244435198669	SLC12A3/FGFR1/GCM1/MAPK3/PTH1R	-0.0576980409209367
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/418	68/9376	0.989586265128061	MAPK3/EIF4EBP1/CSF1R	-0.0186166286409212
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/418	44/9376	1.0195737277077	ARHGDIB/DYNLL1	0.0281112893722296
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/418	20/9376	1.12153110047847	SOAT1	0.117523731366152
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/418	20/9376	1.12153110047847	NANS	0.117523731366152
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/418	94/9376	0.954494553598697	IL17RE/CEBPB/MAPK3/IL17D	-0.0957799870255346
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/418	70/9376	0.961312371838688	EGLN3/MAPK3/ARNT2	-0.0701791091503155
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/418	46/9376	0.975244435198669	FTL/HMOX1	-0.0363562585489799
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/418	238/9376	0.942463109645772	FLT1/GNGT1/FGFR1/RASGRF2/GNG4/MAPK3/GNG10/RALB/CSF1R/FGF1	-0.194212660636394
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/418	47/9376	0.954494553598697	LDHA/AKR1A1	-0.0675558575946539
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/418	73/9376	0.921806383954906	BST2/MX1/PPIA	-0.14487367168994
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/418	73/9376	0.921806383954906	ERBB2/MAPK3/CDK4	-0.14487367168994
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/418	49/9376	0.915535592227321	MAOA/GRIN2D	-0.12804689241569
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/418	99/9376	0.906287757962399	ERBB2/MAPK3/NOTCH2/CDK4	-0.202478258765994
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/418	99/9376	0.906287757962399	PLPP2/MAPK3/RHEB/EIF4EBP1	-0.202478258765994
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/418	23/9376	0.975244435198669	NOS2	-0.0256761284777755
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/418	23/9376	0.975244435198669	B4GALT2	-0.0256761284777755
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/418	23/9376	0.975244435198669	ATP1A4	-0.0256761284777755
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/418	148/9376	0.909349540928488	FGFR1/ERBB2/MAPK3/NOTCH2/FGF1/CDK4	-0.240112805766165
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/418	75/9376	0.897224880382775	ATP1A4/GPX3/GPX8	-0.193028773175325
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	16/418	388/9376	0.924974103487397	TUBB2A/LPL/SLC39A6/MAPK3/COX7A2L/TUBB6/RTN3/DKK1/PPIF/SLC39A8/NOS2/SLC39A14/COX7B2/XBP1/EIF2AK2/GRIN2D	-0.326034662444177
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/418	76/9376	0.885419289851423	ATP1A4/ACTB/ACTG1	-0.216643209750856
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/418	24/9376	0.934609250398724	EXTL3	-0.0692847952214824
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/418	77/9376	0.873920338035171	SMAD3/MAPK3/CDK4	-0.239960923413538
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/418	103/9376	0.871092116876481	IFNGR2/MAPK3/NOS2/SERPINE1	-0.284155593331238
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/418	178/9376	0.882103112735874	NOTUM/GPC4/SMAD3/DKK1/SFRP1/TLE6/CTNND2	-0.343031409238455
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/418	26/9376	0.862716231137284	SCARB1	-0.151414794677478
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/418	80/9376	0.841148325358852	ERBB2/MAPK3/EIF4EBP1	-0.308217280069654
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/418	27/9376	0.830763778132199	AACS	-0.190222056934938
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/418	158/9376	0.851795772515293	MAPK3/RHEB/EIF4EBP1/RPS6KA1/CASTOR1/LAMTOR1	-0.405825220755624
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/418	56/9376	0.801093643198906	SAR1A/ARF1	-0.322480137425014
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/418	28/9376	0.801093643198906	ATP6V0E1	-0.227686130673508
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/418	109/9376	0.823142092094289	IRF9/MAPK3/STAT1/CD40	-0.401177345883044
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/418	109/9376	0.823142092094289	PTPRF/PRKAG2/RPS6KA1/CD36	-0.401177345883044
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/418	235/9376	0.859045098238827	PRKAG2/FGFR1/ACSL5/ACTB/COX7A2L/RHEB/RPS6KA1/ACTG1/COX7B2	-0.472699899454468
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/418	110/9376	0.815658982166159	ANAPC13/MAPK3/MAD2L2/RPS6KA1	-0.420088144980475
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/418	29/9376	0.77346972446791	GNGT1	-0.263910932281176
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/418	163/9376	0.82566706783691	HSPG2/CCNE1/PTK2B/SMAD3/MAPK3/STAT1	-0.484999120907216
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/418	138/9376	0.812703695998891	CCNE1/ANAPC13/MAPK3/MAD2L2/RPS6KA1	-0.478793252754971
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/418	138/9376	0.812703695998891	PTPRF/PRKAG2/MAPK3/RHEB/EIF4EBP1	-0.478793252754971
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/418	86/9376	0.78246355847335	ERBB2/MAPK3/EIF4EBP1	-0.437765607421936
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/418	30/9376	0.747687400318979	PIGT	-0.298988804989104
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/418	30/9376	0.747687400318979	DHFR	-0.298988804989104
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/418	59/9376	0.760360068120996	ERBB2/MAPK3	-0.39885532592762
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/418	87/9376	0.77346972446791	SMAD3/MAPK3/RALB	-0.458531998471568
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/418	60/9376	0.747687400318979	MAPK3/HSPB1	-0.423514294847507
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/418	60/9376	0.747687400318979	MAPK3/LYN	-0.423514294847507
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/418	31/9376	0.723568451921593	PGM1	-0.33300215958135
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/418	31/9376	0.723568451921593	AKR1A1	-0.33300215958135
NA	NA	hsa04981	Folate transport and metabolism	1/418	31/9376	0.723568451921593	DHFR	-0.33300215958135
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/418	115/9376	0.780195548158935	GNGT1/GNG4/MAPK3/GNG10	-0.51230042047951
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/418	89/9376	0.756088382345035	TUBB2A/MAPK3/TUBB6	-0.49941090021293
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/418	89/9376	0.756088382345035	GNGT1/GNG4/GNG10	-0.49941090021293
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/418	142/9376	0.789810634139767	UBE2L6/ANAPC13/FBXO2/CDC34/UBE2S	-0.545165327651048
NA	NA	hsa04081	Hormone signaling	8/418	219/9376	0.819383452404361	GUCA2A/GNGT1/DIO2/POMC/GNG4/EPOR/GNG10/PTH1R	-0.584213027310026
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/418	32/9376	0.700956937799043	LDHA	-0.366024836695807
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/418	32/9376	0.700956937799043	BOK	-0.366024836695807
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/418	90/9376	0.747687400318979	PRKAG2/RHEB/EIF4EBP1	-0.519534154256228
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/418	90/9376	0.747687400318979	IFNGR2/MAPK3/STAT1	-0.519534154256228
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/418	144/9376	0.778841041998937	FGFR1/IL6ST/SMAD3/ESX1/MAPK3	-0.57770500918174
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/418	170/9376	0.791669012102449	ACTB/SMAD3/MAPK3/HMOX1/ACTG1/CDK4	-0.592121865478463
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/418	91/9376	0.739471055260529	GNGT1/GNG4/GNG10	-0.539453447058913
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/418	33/9376	0.679715818471799	AGXT	-0.398123245180087
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/418	34/9376	0.659724176752041	PRKAG2	-0.429357318991121
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	10/418	275/9376	0.815658982166159	CAV1/TUBB2A/CAV2/MAPK3/COX7A2L/TUBB6/C7/PPIF/COX7B2/GRIN2D	-0.670211724308319
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/418	65/9376	0.690172984909827	KISS1R/MAPK3	-0.541434652881953
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/418	226/9376	0.79400431892281	ATP1A4/POMC/MAPK3/PTGER3/HCAR1/ORAI1/FXYD1/GRIN2D	-0.677126853799102
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/418	122/9376	0.735430229821947	PRKAG2/RHEB/EIF4EBP1/CD36	-0.635365512695691
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/418	66/9376	0.679715818471799	CYP11A1/HSD3B1	-0.564028263677987
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/418	150/9376	0.747687400318979	CCNE1/ERBB2/SMAD3/MAPK3/FGF1	-0.672893127556533
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/418	36/9376	0.623072833599149	PGM1	-0.489444555594278
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/418	37/9376	0.606233027285659	MAOA	-0.518391905010994
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/418	37/9376	0.606233027285659	LAMA4	-0.518391905010994
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/418	37/9376	0.606233027285659	MAPK3	-0.518391905010994
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/418	69/9376	0.650162956799112	MAPK3/LYN	-0.63001912351564
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/418	69/9376	0.650162956799112	MAOA/GRIN2D	-0.63001912351564
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/418	71/9376	0.631848507311814	MAPK3/STAT1	-0.672613843155843
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/418	71/9376	0.631848507311814	ATP6V0E1/LYN	-0.672613843155843
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/418	101/9376	0.66625609929414	POMC/MAPK3/EDNRB	-0.728425792835712
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	13/418	368/9376	0.792386103598918	TUBB2A/GPX3/ACTB/COX7A2L/TUBB6/NOS2/GPX8/ACTG1/ANG/PFN1/COX7B2/XBP1/GRIN2D	-0.877676337522021
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/418	41/9376	0.547088341696814	GRIN2D	-0.627793069714108
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/418	133/9376	0.674605173220132	GNGT1/GNG4/MAOA/GNG10	-0.816391055950895
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/418	105/9376	0.640874914559125	IL1R1/LYN/CD40	-0.799365409518939
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/418	105/9376	0.640874914559125	CCZ1B/CITED2/FKBP8	-0.799365409518939
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/418	75/9376	0.598149920255183	PYCR1/PHGDH	-0.75474130492326
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/418	75/9376	0.598149920255183	ERBB2/MAPK3	-0.75474130492326
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/418	76/9376	0.590279526567615	MAPK3/CDK4	-0.774678026955259
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/418	323/9376	0.763891152028678	CCNE1/ERBB2/ITGA5/FSCN1/MAPK3/STMN1/HMOX1/NOTCH2/SLC7A1/TIMP3/IGF2BP1	-0.932793504459708
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/418	43/9376	0.521642372315567	ACSL5	-0.679116915954866
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/418	191/9376	0.704626869410556	GNGT1/GNG4/MAPK3/MAOA/GNG10/GRIN2D	-0.890874112886803
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/418	44/9376	0.50978686385385	MBD4	-0.704031624944507
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/418	166/9376	0.675621144866548	ATP1A4/MAPK3/VASP/EDNRB/PPIF	-0.910846126189444
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/418	78/9376	0.575144154091523	IMPA2/PLCD3	-0.813883752662826
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/418	139/9376	0.645485525455234	KRT10/KRT19/POMC/MAPK3	-0.909586801930017
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/418	47/9376	0.477247276799348	MAPK3	-0.776061138139927
NA	NA	hsa04082	Neuroactive ligand signaling	6/418	199/9376	0.676300161092544	SLC6A2/GNGT1/POMC/GNG4/GNG10/GRIN2D	-0.996981054748352
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/418	48/9376	0.467304625199362	AACS	-0.799233218198322
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/418	48/9376	0.467304625199362	ATP1A4	-0.799233218198322
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/418	116/9376	0.580102293350932	AGXT/PHGDH/GCSH	-0.982958661688378
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/418	50/9376	0.448612440191388	CD40	-0.844427775802096
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/418	117/9376	0.575144154091523	MORF4L2/ACTB/ACTG1	-0.998897065460776
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/418	205/9376	0.656506010036177	PDK3/SMAD3/COX7A2L/PPIF/CD36/COX7B2	-1.07412784858052
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/418	149/9376	0.602164349250185	GNGT1/GNG4/MAPK3/GNG10	-1.05738908331893
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/418	119/9376	0.565477865787463	CEBPB/MAPK3/BCL3	-1.03043002029544
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/418	370/9376	0.727479632742791	TSPO/PGRMC1/KISS1R/POMC/LYPD6B/LPAR2/EDNRB/PTGER3/SLURP2/ADM/PTH1R/GRIN2D	-1.15531950710018
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/418	120/9376	0.560765550239234	ARHGDIB/MAPK3/RPS6KA1	-1.04602868722708
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/418	90/9376	0.498458266879319	ATP1A4/SCARB1	-1.0327191764124
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/418	154/9376	0.582613558690114	PRKAG2/ACTB/MAPK3/ACTG1	-1.1281176356588
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/418	56/9376	0.400546821599453	SCUBE2	-0.971873128940679
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/418	93/9376	0.482378967947729	PTK2B/MAPK3	-1.08362112620147
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/418	157/9376	0.57148081553043	PRKAG2/COX7A2L/COX7B2/XBP1	-1.1696244505532
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/418	216/9376	0.623072833599149	TNFSF10/MAPK3/LYN/CD36/CD40/XBP1	-1.2106115928358
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/418	57/9376	0.39351968437841	ACSL5	-0.992059525953322
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/418	95/9376	0.472223621254092	ATP6V0E1/FLT1	-1.11681854091488
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/418	59/9376	0.380180034060498	PTGER3	-1.03162479054646
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/418	98/9376	0.457767796113661	IMPA2/PLCD3	-1.16557281881029
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/418	99/9376	0.4531438789812	IL1R1/IL1RAP	-1.18155827639878
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/418	195/9376	0.575144154091523	ACTB/MAPK3/PPIF/ACTG1/VWF	-1.29503695162277
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	6/418	227/9376	0.592879876904918	MAPK3/COX7A2L/PPIF/HMOX1/AKR1A1/COX7B2	-1.34127223326789
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/418	138/9376	0.487622217599334	ATP6V0E1/COX7A2L/COX7B2	-1.30981241932857
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/418	107/9376	0.419263962795689	PRKAG2/LDHA	-1.30503594737235
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/418	68/9376	0.32986208837602	CYP26A1	-1.19800521064956
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/418	108/9376	0.4153818890661	SUMO2/SUMO1	-1.31995577512453
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/418	143/9376	0.470572489711246	C2/C7/CD40	-1.37807024457484
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/418	69/9376	0.325081478399556	ORAI1	-1.21545612074881
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/418	144/9376	0.467304625199362	PPIF/XBP1/GRIN2D	-1.39149139230794
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/418	70/9376	0.320437457279563	SULT1A1	-1.23272209041067
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/418	72/9376	0.311536416799575	ISG15	-1.26671997859048
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/418	73/9376	0.307268794651635	MAOA	-1.28346172346268
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/418	308/9376	0.582613558690114	TUBB2A/GPX3/CLTB/COX7A2L/TUBB6/PPIF/GPX8/COX7B2	-1.60888939697312
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/418	154/9376	0.436960169017585	ATP1A4/TPM2/MAPK3	-1.52179155824093
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/418	122/9376	0.367715114910973	MAPK3/CDK4	-1.51843504234805
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/418	122/9376	0.367715114910973	MAPK3/STAT1	-1.51843504234805
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/418	125/9376	0.35888995215311	SPTSSA/MAPK3	-1.55869628213403
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/418	86/9376	0.260821186157783	ATP1A4	-1.48750738112733
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/418	169/9376	0.398176722063362	LAMP1/MAPK3/RHEB	-1.7053813631071
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	13/418	480/9376	0.607496012759171	TUBB2A/UBE2L6/GPX3/MAPK3/COX7A2L/TUBB6/DKK1/PPIF/NOS2/GPX8/COX7B2/XBP1/GRIN2D	-1.90693352723795
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/418	134/9376	0.334785403127901	MAPK3/ADM	-1.67532642056212
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/418	93/9376	0.241189483973864	ATP1A4	-1.58854268863388
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/418	217/9376	0.413467686812339	MAPK3/EIF4EBP1/RPS6KA1/NOTCH2	-1.88827842347134
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/418	144/9376	0.311536416799575	C2/PRKAG2	-1.79838458387104
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/418	102/9376	0.219908058917347	ATP1A4	-1.7111204492158
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/418	103/9376	0.21777302921912	SSU72	-1.72428685985756
Genetic Information Processing	Translation	hsa03010	Ribosome	2/418	222/9376	0.202077675761886	MRPL41/RPL10	-2.59896181746337
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/418	183/9376	0.122571704970324	RPP25	-2.58926678422843
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/418	449/9376	0.0499568418921367	NCALD	-4.45637765363549