ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 26/755 168/18639 0.154761904761905 3.82067171239357 4.08475596268125e-09 3.80290780125624e-06 GO:0005539 glycosaminoglycan binding 31/755 242/18639 0.128099173553719 3.16243774287122 1.4496606059011e-08 6.74817012046963e-06 GO:0005178 integrin binding 24/755 161/18639 0.149068322981366 3.68011188350952 3.39642951206876e-08 1.054025291912e-05 GO:0019838 growth factor binding 21/755 136/18639 0.154411764705882 3.81202765874562 1.31432948773299e-07 3.05910188269853e-05 GO:0019955 cytokine binding 21/755 144/18639 0.145833333333333 3.60024834437086 3.53885058603615e-07 6.58933979119931e-05 GO:0016757 glycosyltransferase activity 29/755 267/18639 0.108614232209738 2.68140486643351 1.43294901936938e-06 0.000222345922838816 GO:0008201 heparin binding 22/755 172/18639 0.127906976744186 3.1576929000462 1.83910396010594e-06 0.00024460082669409 GO:1901681 sulfur compound binding 29/755 275/18639 0.105454545454545 2.60340036122818 2.60319303595909e-06 0.000302946589559739 GO:0008194 UDP-glycosyltransferase activity 19/755 145/18639 0.131034482758621 3.23490294587805 6.41667755910866e-06 0.000663769645281129 GO:0033218 amide binding 26/755 247/18639 0.105263157894737 2.59867549668874 8.77276728110911e-06 0.000816744633871258 GO:0042277 peptide binding 25/755 249/18639 0.100401606425703 2.47865634724328 2.90903217226571e-05 0.00242107334572147 GO:0004896 cytokine receptor activity 14/755 96/18639 0.145833333333333 3.60024834437086 3.12061011263777e-05 0.00242107334572147 GO:0016209 antioxidant activity 13/755 86/18639 0.151162790697674 3.73181888187279 4.043261943172e-05 0.0028955975916101 GO:0031406 carboxylic acid binding 20/755 187/18639 0.106951871657754 2.64036547791904 7.45311392727018e-05 0.00422114586711118 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/755 36/18639 0.222222222222222 5.48609271523179 7.70778514939743e-05 0.00422114586711118 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/755 36/18639 0.222222222222222 5.48609271523179 7.70778514939743e-05 0.00422114586711118 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/755 36/18639 0.222222222222222 5.48609271523179 7.70778514939743e-05 0.00422114586711118 GO:0004601 peroxidase activity 10/755 57/18639 0.175438596491228 4.33112582781457 8.60766448847374e-05 0.00423719408579259 GO:0043177 organic acid binding 20/755 189/18639 0.105820105820106 2.61242510249133 8.64733486896446e-05 0.00423719408579259 GO:0031418 L-ascorbic acid binding 6/755 20/18639 0.3 7.40622516556291 0.000103052085550599 0.00479707458238038 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 10/755 59/18639 0.169491525423729 4.18430800314289 0.000116424130037269 0.00516146976498559 GO:0016853 isomerase activity 19/755 180/18639 0.105555555555556 2.6058940397351 0.000133157597257039 0.00550372082847156 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/755 39/18639 0.205128205128205 5.06408558329088 0.000140751544665936 0.00550372082847156 GO:0005518 collagen binding 11/755 72/18639 0.152777777777778 3.77168874172185 0.000141878947243091 0.00550372082847156 GO:0015026 coreceptor activity 10/755 61/18639 0.163934426229508 4.04711757681033 0.000155354045218571 0.00578538464393959 GO:0016859 cis-trans isomerase activity 8/755 42/18639 0.19047619047619 4.70236518448439 0.000242566753300753 0.00868575566626929 GO:0008375 acetylglucosaminyltransferase activity 8/755 43/18639 0.186046511627907 4.59300785461266 0.00028755713454141 0.00991539600955751 GO:0050431 transforming growth factor beta binding 6/755 24/18639 0.25 6.17185430463576 0.00031153085519956 0.0103584009353854 GO:0016758 hexosyltransferase activity 19/755 197/18639 0.0964467005076142 2.38101993478334 0.000425397604623146 0.0136567299966948 GO:0030246 carbohydrate binding 24/755 280/18639 0.0857142857142857 2.11606433301798 0.000468601837140404 0.0145422770125905 GO:0001540 amyloid-beta binding 11/755 83/18639 0.132530120481928 3.27182637836113 0.000506476473335492 0.0152106321508175 GO:0043394 proteoglycan binding 7/755 37/18639 0.189189189189189 4.67059244675139 0.000618990566215487 0.0180087567858318 GO:0017124 SH3 domain binding 13/755 115/18639 0.11304347826087 2.79075151166139 0.000775235656946685 0.0213290924839758 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/755 19/18639 0.263157894736842 6.49668874172185 0.000778935708329945 0.0213290924839758 GO:0004857 enzyme inhibitor activity 31/755 416/18639 0.0745192307692308 1.83968734080489 0.00085598168915992 0.0227691129316539 GO:0035250 UDP-galactosyltransferase activity 6/755 29/18639 0.206896551724138 5.10774149349167 0.000925125682121987 0.0239247780570992 GO:0003779 actin binding 32/755 443/18639 0.072234762979684 1.78328973136203 0.00119046599879566 0.0299546985102367 GO:0008378 galactosyltransferase activity 6/755 32/18639 0.1875 4.62889072847682 0.00159173926064826 0.038073678349826 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/755 22/18639 0.227272727272727 5.61077664057796 0.00159492315321505 0.038073678349826 GO:0140375 immune receptor activity 15/755 156/18639 0.0961538461538462 2.3737901171676 0.00170346928387217 0.0396482475821248 GO:0030547 signaling receptor inhibitor activity 7/755 44/18639 0.159090909090909 3.92754364840458 0.0018027251483922 0.0409350515403205 GO:0004602 glutathione peroxidase activity 5/755 23/18639 0.217391304347826 5.36682983011805 0.00197076919773862 0.0412252866324173 GO:0140103 catalytic activity, acting on a glycoprotein 5/755 23/18639 0.217391304347826 5.36682983011805 0.00197076919773862 0.0412252866324173 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 5/755 23/18639 0.217391304347826 5.36682983011805 0.00197076919773862 0.0412252866324173 GO:0042605 peptide antigen binding 7/755 45/18639 0.155555555555556 3.84026490066225 0.00206148826683986 0.0412252866324173 GO:0004860 protein kinase inhibitor activity 10/755 84/18639 0.119047619047619 2.93897824030274 0.00206535472792418 0.0412252866324173 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 13/755 128/18639 0.1015625 2.50731581125828 0.00208119062483739 0.0412252866324173 GO:0008376 acetylgalactosaminyltransferase activity 6/755 34/18639 0.176470588235294 4.35660303856642 0.00220554504865946 0.0427783841729574 GO:0043495 protein-membrane adaptor activity 7/755 47/18639 0.148936170212766 3.6768493729745 0.00266433850197517 0.0506224315375283 GO:0048029 monosaccharide binding 9/755 74/18639 0.121621621621622 3.00252371576875 0.00293716122824949 0.0546899420700054 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/755 16/18639 0.25 6.17185430463576 0.0032913728690608 0.0600836890410903 GO:0016763 pentosyltransferase activity 7/755 49/18639 0.142857142857143 3.52677388836329 0.00339402427811462 0.0605497694904693 GO:0019210 kinase inhibitor activity 10/755 90/18639 0.111111111111111 2.74304635761589 0.00344697935874852 0.0605497694904693 GO:0005044 scavenger receptor activity 5/755 27/18639 0.185185185185185 4.57174392935982 0.00413641195350673 0.0698534231802965 GO:0016018 cyclosporin A binding 4/755 17/18639 0.235294117647059 5.80880405142189 0.00416766836989064 0.0698534231802965 GO:0019199 transmembrane receptor protein kinase activity 9/755 78/18639 0.115384615384615 2.84854814060112 0.00420170966498024 0.0698534231802965 GO:0051015 actin filament binding 17/755 209/18639 0.0813397129186603 2.00806742925948 0.00508163164486446 0.0829999835327861 GO:0099602 neurotransmitter receptor regulator activity 4/755 18/18639 0.222222222222222 5.48609271523179 0.00518882885296217 0.0832896493466859 GO:0016860 intramolecular oxidoreductase activity 7/755 53/18639 0.132075471698113 3.26060227414719 0.00529931595777755 0.083621409435439 GO:0001618 virus receptor activity 9/755 81/18639 0.111111111111111 2.74304635761589 0.00540179027855191 0.0838177791555304 GO:0140272 exogenous protein binding 9/755 82/18639 0.109756097560976 2.70959457276692 0.00585569518068894 0.0878202280990251 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 7/755 54/18639 0.12962962962963 3.20022075055188 0.00588082639492669 0.0878202280990251 GO:0003756 protein disulfide isomerase activity 4/755 19/18639 0.210526315789474 5.19735099337748 0.00636480035819742 0.0878202280990251 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4/755 19/18639 0.210526315789474 5.19735099337748 0.00636480035819742 0.0878202280990251 GO:0050145 nucleoside monophosphate kinase activity 4/755 19/18639 0.210526315789474 5.19735099337748 0.00636480035819742 0.0878202280990251 GO:0005522 profilin binding 3/755 10/18639 0.3 7.40622516556291 0.00641590842613798 0.0878202280990251 GO:0035374 chondroitin sulfate binding 3/755 10/18639 0.3 7.40622516556291 0.00641590842613798 0.0878202280990251 GO:0043208 glycosphingolipid binding 3/755 10/18639 0.3 7.40622516556291 0.00641590842613798 0.0878202280990251 GO:0140313 molecular sequestering activity 7/755 55/18639 0.127272727272727 3.14203491872366 0.00650869574525535 0.0878202280990251 GO:0048185 activin binding 3/755 11/18639 0.272727272727273 6.73293196869356 0.00855877976911627 0.113831770929246 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/755 21/18639 0.19047619047619 4.70236518448439 0.00921798722512613 0.120872480374541 GO:0019956 chemokine binding 5/755 33/18639 0.151515151515152 3.74051776038531 0.00996186902693478 0.126610030361066 GO:0140311 protein sequestering activity 5/755 33/18639 0.151515151515152 3.74051776038531 0.00996186902693478 0.126610030361066 GO:0004180 carboxypeptidase activity 6/755 46/18639 0.130434782608696 3.22009789807083 0.0101995190946079 0.126610030361066 GO:0030291 protein serine/threonine kinase inhibitor activity 6/755 46/18639 0.130434782608696 3.22009789807083 0.0101995190946079 0.126610030361066 GO:0031543 peptidyl-proline dioxygenase activity 3/755 12/18639 0.25 6.17185430463576 0.0110721148286317 0.135633406650738 GO:0015035 protein-disulfide reductase activity 5/755 34/18639 0.147058823529412 3.63050253213868 0.0112991662645685 0.136617192107964 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/755 23/18639 0.173913043478261 4.29346386409444 0.0127943661508212 0.148894436080182 GO:0042171 lysophosphatidic acid acyltransferase activity 4/755 23/18639 0.173913043478261 4.29346386409444 0.0127943661508212 0.148894436080182 GO:0071617 lysophospholipid acyltransferase activity 4/755 23/18639 0.173913043478261 4.29346386409444 0.0127943661508212 0.148894436080182 GO:0140410 monoatomic cation:bicarbonate symporter activity 3/755 13/18639 0.230769230769231 5.69709628120224 0.0139663563611708 0.160526886077161 GO:0005017 platelet-derived growth factor receptor activity 6/755 50/18639 0.12 2.96249006622517 0.0151111818525893 0.169500124153742 GO:0005019 platelet-derived growth factor beta-receptor activity 6/755 50/18639 0.12 2.96249006622517 0.0151111818525893 0.169500124153742 GO:0038024 cargo receptor activity 7/755 65/18639 0.107692307692308 2.65864493122771 0.0158078588319269 0.175203768720523 GO:0003924 GTPase activity 22/755 331/18639 0.0664652567975831 1.64085552509954 0.0161496603081067 0.176886279374674 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/755 25/18639 0.16 3.94998675496689 0.0171501357096667 0.182483689278383 GO:0005161 platelet-derived growth factor receptor binding 3/755 14/18639 0.214285714285714 5.29016083254494 0.01724872680612 0.182483689278383 GO:0008191 metalloendopeptidase inhibitor activity 3/755 14/18639 0.214285714285714 5.29016083254494 0.01724872680612 0.182483689278383 GO:0050840 extracellular matrix binding 7/755 67/18639 0.104477611940299 2.57928239596718 0.0184345757401567 0.192838090045909 GO:0005160 transforming growth factor beta receptor binding 4/755 26/18639 0.153846153846154 3.79806418746816 0.0196347437748366 0.203110516159698 GO:0004129 cytochrome-c oxidase activity 3/755 15/18639 0.2 4.93748344370861 0.0209235424547825 0.209460408875295 GO:0031386 protein tag activity 3/755 15/18639 0.2 4.93748344370861 0.0209235424547825 0.209460408875295 GO:0141047 molecular tag activity 3/755 15/18639 0.2 4.93748344370861 0.0209235424547825 0.209460408875295 GO:0015036 disulfide oxidoreductase activity 5/755 40/18639 0.125 3.08592715231788 0.0219256013697968 0.217156753992349 GO:0005385 zinc ion transmembrane transporter activity 4/755 27/18639 0.148148148148148 3.65739514348786 0.02233010583072 0.217783311920746 GO:0002020 protease binding 11/755 136/18639 0.0808823529411765 1.99677639267628 0.0224567110036429 0.217783311920746 GO:0008374 O-acyltransferase activity 6/755 55/18639 0.109090909090909 2.69317278747742 0.0232909980063763 0.223545558184911 GO:0042287 MHC protein binding 5/755 41/18639 0.121951219512195 3.01066063640769 0.0241647435194751 0.228117861224097 GO:0005024 transforming growth factor beta receptor activity 3/755 16/18639 0.1875 4.62889072847682 0.0249925046668721 0.228117861224097 GO:0005521 lamin binding 3/755 16/18639 0.1875 4.62889072847682 0.0249925046668721 0.228117861224097 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/755 16/18639 0.1875 4.62889072847682 0.0249925046668721 0.228117861224097 GO:0022841 potassium ion leak channel activity 3/755 16/18639 0.1875 4.62889072847682 0.0249925046668721 0.228117861224097 GO:0046625 sphingolipid binding 4/755 28/18639 0.142857142857143 3.52677388836329 0.0252400346073239 0.228140506984646 GO:0008236 serine-type peptidase activity 14/755 194/18639 0.0721649484536082 1.78156619102888 0.0266657467265913 0.238709713485158 GO:0004629 phospholipase C activity 4/755 29/18639 0.137931034482759 3.40516099566111 0.0283676412541543 0.251526419120168 GO:0005319 lipid transporter activity 13/755 178/18639 0.0730337078651685 1.8030136170846 0.0293419055081471 0.251583272349593 GO:0004550 nucleoside diphosphate kinase activity 3/755 17/18639 0.176470588235294 4.35660303856642 0.0294549695876538 0.251583272349593 GO:0017110 nucleoside diphosphate phosphatase activity 3/755 17/18639 0.176470588235294 4.35660303856642 0.0294549695876538 0.251583272349593 GO:0030548 acetylcholine receptor regulator activity 3/755 17/18639 0.176470588235294 4.35660303856642 0.0294549695876538 0.251583272349593 GO:0017171 serine hydrolase activity 14/755 198/18639 0.0707070707070707 1.74557495484648 0.0309971534546631 0.252595021089285 GO:0045296 cadherin binding 21/755 334/18639 0.062874251497006 1.55220287901019 0.0314518856358972 0.252595021089285 GO:0015459 potassium channel regulator activity 6/755 59/18639 0.101694915254237 2.51058480188573 0.031652975300774 0.252595021089285 GO:0001965 G-protein alpha-subunit binding 4/755 30/18639 0.133333333333333 3.29165562913907 0.0317153490334017 0.252595021089285 GO:0001968 fibronectin binding 4/755 30/18639 0.133333333333333 3.29165562913907 0.0317153490334017 0.252595021089285 GO:0048019 receptor antagonist activity 4/755 30/18639 0.133333333333333 3.29165562913907 0.0317153490334017 0.252595021089285 GO:0070566 adenylyltransferase activity 4/755 30/18639 0.133333333333333 3.29165562913907 0.0317153490334017 0.252595021089285 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/755 44/18639 0.113636363636364 2.80538832028898 0.0317439500187394 0.252595021089285 GO:0004620 phospholipase activity 9/755 109/18639 0.0825688073394495 2.03841059602649 0.0328591203796393 0.255816605485676 GO:0043178 alcohol binding 8/755 92/18639 0.0869565217391304 2.14673193204722 0.0329413380392279 0.255816605485676 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 13/755 181/18639 0.0718232044198895 1.77312941348652 0.0329731392677563 0.255816605485676 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/755 60/18639 0.1 2.4687417218543 0.0340123248698575 0.259553069293748 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/755 60/18639 0.1 2.4687417218543 0.0340123248698575 0.259553069293748 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/755 18/18639 0.166666666666667 4.11456953642384 0.0343081977345921 0.259682374722807 GO:0016411 acylglycerol O-acyltransferase activity 4/755 31/18639 0.129032258064516 3.18547318948943 0.0352849100893901 0.264921381396953 GO:0016298 lipase activity 10/755 130/18639 0.0769230769230769 1.89903209373408 0.0385889275000261 0.28105955263681 GO:0044389 ubiquitin-like protein ligase binding 20/755 322/18639 0.062111801242236 1.5333799514623 0.0391170894920914 0.28105955263681 GO:0015245 fatty acid transmembrane transporter activity 3/755 19/18639 0.157894736842105 3.89801324503311 0.0395475847426661 0.28105955263681 GO:0022840 leak channel activity 3/755 19/18639 0.157894736842105 3.89801324503311 0.0395475847426661 0.28105955263681 GO:0022842 narrow pore channel activity 3/755 19/18639 0.157894736842105 3.89801324503311 0.0395475847426661 0.28105955263681 GO:0043395 heparan sulfate proteoglycan binding 3/755 19/18639 0.157894736842105 3.89801324503311 0.0395475847426661 0.28105955263681 GO:0097001 ceramide binding 3/755 19/18639 0.157894736842105 3.89801324503311 0.0395475847426661 0.28105955263681 GO:0016247 channel regulator activity 12/755 168/18639 0.0714285714285714 1.76338694418165 0.0408484409901725 0.286402237602549 GO:0004175 endopeptidase activity 24/755 405/18639 0.0592592592592593 1.46295805739514 0.0410163045840362 0.286402237602549 GO:0140297 DNA-binding transcription factor binding 28/755 488/18639 0.0573770491803279 1.41649115188362 0.0412222339836107 0.286402237602549 GO:0061134 peptidase regulator activity 15/755 226/18639 0.0663716814159292 1.63854539061126 0.0422033150919334 0.290110906081664 GO:0035401 histone H3Y41 kinase activity 9/755 115/18639 0.0782608695652174 1.9320587388425 0.0439546558996176 0.290110906081664 GO:0140801 histone H2AXY142 kinase activity 9/755 115/18639 0.0782608695652174 1.9320587388425 0.0439546558996176 0.290110906081664 GO:0141108 transporter regulator activity 12/755 170/18639 0.0705882352941176 1.74264121542657 0.044047557722767 0.290110906081664 GO:0001972 retinoic acid binding 3/755 20/18639 0.15 3.70311258278146 0.0451668744821779 0.290110906081664 GO:0010851 cyclase regulator activity 3/755 20/18639 0.15 3.70311258278146 0.0451668744821779 0.290110906081664 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/755 20/18639 0.15 3.70311258278146 0.0451668744821779 0.290110906081664 GO:0042288 MHC class I protein binding 3/755 20/18639 0.15 3.70311258278146 0.0451668744821779 0.290110906081664 GO:0005004 GPI-linked ephrin receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0005008 hepatocyte growth factor receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0005009 insulin receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0005011 macrophage colony-stimulating factor receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0005018 platelet-derived growth factor alpha-receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0005020 stem cell factor receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0008288 boss receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0036332 placental growth factor receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0038062 protein tyrosine kinase collagen receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0060175 brain-derived neurotrophic factor receptor activity 5/755 49/18639 0.102040816326531 2.51912420597378 0.047365045890884 0.290110906081664 GO:0044325 transmembrane transporter binding 10/755 136/18639 0.0735294117647059 1.81525126606934 0.0498559000661072 0.303371522624482 GO:0005006 epidermal growth factor receptor activity 5/755 50/18639 0.1 2.4687417218543 0.0509488085618057 0.305310443262565 GO:0005007 fibroblast growth factor receptor activity 5/755 50/18639 0.1 2.4687417218543 0.0509488085618057 0.305310443262565 GO:0008373 sialyltransferase activity 3/755 21/18639 0.142857142857143 3.52677388836329 0.0511583556916865 0.305310443262565 GO:0016500 protein-hormone receptor activity 6/755 67/18639 0.0895522388059701 2.21081348225759 0.0536929436632701 0.317998578496752 GO:0005010 insulin-like growth factor receptor activity 5/755 51/18639 0.0980392156862745 2.42033502142579 0.0546870374750346 0.317998578496752 GO:0005021 vascular endothelial growth factor receptor activity 5/755 51/18639 0.0980392156862745 2.42033502142579 0.0546870374750346 0.317998578496752 GO:0005030 neurotrophin receptor activity 5/755 51/18639 0.0980392156862745 2.42033502142579 0.0546870374750346 0.317998578496752 GO:0008238 exopeptidase activity 8/755 102/18639 0.0784313725490196 1.93626801714063 0.0549922353791375 0.317998578496752 GO:0005548 phospholipid transporter activity 6/755 68/18639 0.0882352941176471 2.17830151928321 0.0569674353963698 0.321681714784213 GO:0030145 manganese ion binding 6/755 68/18639 0.0882352941176471 2.17830151928321 0.0569674353963698 0.321681714784213 GO:0015377 chloride:monoatomic cation symporter activity 3/755 22/18639 0.136363636363636 3.36646598434678 0.0575130432014273 0.321681714784213 GO:0004713 protein tyrosine kinase activity 10/755 140/18639 0.0714285714285714 1.76338694418165 0.0584778417678702 0.321681714784213 GO:0004382 GDP phosphatase activity 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.321681714784213 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.321681714784213 GO:0004955 prostaglandin receptor activity 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.321681714784213 GO:0005528 FK506 binding 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.321681714784213 GO:0008190 eukaryotic initiation factor 4E binding 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.321681714784213 GO:0019911 structural constituent of myelin sheath 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.321681714784213 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.321681714784213 GO:0099106 ion channel regulator activity 11/755 160/18639 0.06875 1.69725993377483 0.0609696445876795 0.328108318561443 GO:0023023 MHC protein complex binding 4/755 37/18639 0.108108108108108 2.66890996957222 0.0613800611892897 0.328418603259935 GO:0005003 ephrin receptor activity 5/755 53/18639 0.0943396226415094 2.32900162439085 0.0626266802879881 0.329409261853768 GO:0005005 transmembrane-ephrin receptor activity 5/755 53/18639 0.0943396226415094 2.32900162439085 0.0626266802879881 0.329409261853768 GO:0038064 collagen receptor activity 5/755 53/18639 0.0943396226415094 2.32900162439085 0.0626266802879881 0.329409261853768 GO:0020037 heme binding 10/755 142/18639 0.0704225352112676 1.7385505083481 0.0631323243852369 0.33020333709357 GO:0016493 C-C chemokine receptor activity 3/755 23/18639 0.130434782608696 3.22009789807083 0.0642208447590182 0.332154174205474 GO:0031681 G-protein beta-subunit binding 3/755 23/18639 0.130434782608696 3.22009789807083 0.0642208447590182 0.332154174205474 GO:0008083 growth factor activity 11/755 162/18639 0.0679012345679012 1.67630610743194 0.0654261046757365 0.332154174205474 GO:0005501 retinoid binding 4/755 38/18639 0.105263157894737 2.59867549668874 0.0664998351958287 0.332154174205474 GO:0019840 isoprenoid binding 4/755 38/18639 0.105263157894737 2.59867549668874 0.0664998351958287 0.332154174205474 GO:0015485 cholesterol binding 5/755 54/18639 0.0925925925925926 2.28587196467991 0.0668273413994079 0.332154174205474 GO:0003953 NAD+ nucleosidase activity 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0004954 prostanoid receptor activity 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0005114 type II transforming growth factor beta receptor binding 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0005225 volume-sensitive anion channel activity 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0008046 axon guidance receptor activity 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0008432 JUN kinase binding 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0034713 type I transforming growth factor beta receptor binding 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0050998 nitric-oxide synthase binding 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0097493 structural molecule activity conferring elasticity 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.332154174205474 GO:0019957 C-C chemokine binding 3/755 24/18639 0.125 3.08592715231788 0.0712707144092179 0.332154174205474 GO:0035035 histone acetyltransferase binding 3/755 24/18639 0.125 3.08592715231788 0.0712707144092179 0.332154174205474 GO:0050699 WW domain binding 3/755 24/18639 0.125 3.08592715231788 0.0712707144092179 0.332154174205474 GO:0008237 metallopeptidase activity 12/755 184/18639 0.0652173913043478 1.61004894903542 0.0713542801730342 0.332154174205474 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/755 39/18639 0.102564102564103 2.53204279164544 0.0718340226183719 0.332723756505991 GO:0170055 lipid transmembrane transporter activity 5/755 56/18639 0.0892857142857143 2.20423368022706 0.0756865902187955 0.348832749968805 GO:0061791 GTPase motor activity 4/755 40/18639 0.1 2.4687417218543 0.0773794027571025 0.353138352778737 GO:1990606 membrane scission GTPase motor activity 4/755 40/18639 0.1 2.4687417218543 0.0773794027571025 0.353138352778737 GO:0004222 metalloendopeptidase activity 8/755 110/18639 0.0727272727272727 1.79544852498495 0.0781517025608805 0.354923097971609 GO:0016504 peptidase activator activity 5/755 57/18639 0.087719298245614 2.16556291390728 0.0803429582074321 0.358491199574633 GO:0005527 macrolide binding 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.358491199574633 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.358491199574633 GO:0008603 cAMP-dependent protein kinase regulator activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.358491199574633 GO:0010853 cyclase activator activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.358491199574633 GO:0015132 prostaglandin transmembrane transporter activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.358491199574633 GO:0016208 AMP binding 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.358491199574633 GO:0070008 serine-type exopeptidase activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.358491199574633 GO:0097677 STAT family protein binding 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.358491199574633 GO:0051213 dioxygenase activity 7/755 93/18639 0.0752688172043011 1.85819269386883 0.0830820573747693 0.358491199574633 GO:0003725 double-stranded RNA binding 6/755 75/18639 0.08 1.97499337748344 0.0831730387842329 0.358491199574633 GO:0001637 G protein-coupled chemoattractant receptor activity 3/755 26/18639 0.115384615384615 2.84854814060112 0.0863485389160048 0.365411316958184 GO:0004435 phosphatidylinositol phospholipase C activity 3/755 26/18639 0.115384615384615 2.84854814060112 0.0863485389160048 0.365411316958184 GO:0004950 chemokine receptor activity 3/755 26/18639 0.115384615384615 2.84854814060112 0.0863485389160048 0.365411316958184 GO:0008198 ferrous iron binding 3/755 26/18639 0.115384615384615 2.84854814060112 0.0863485389160048 0.365411316958184 GO:0046906 tetrapyrrole binding 10/755 152/18639 0.0657894736842105 1.62417218543046 0.0899220700941119 0.378811978541259 GO:0004867 serine-type endopeptidase inhibitor activity 7/755 95/18639 0.0736842105263158 1.81907284768212 0.0906291293648314 0.380070808282243 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/755 27/18639 0.111111111111111 2.74304635761589 0.0943508430516655 0.386865727590373 GO:0004465 lipoprotein lipase activity 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.386865727590373 GO:0008035 high-density lipoprotein particle binding 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.386865727590373 GO:0008253 5'-nucleotidase activity 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.386865727590373 GO:0039706 co-receptor binding 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.386865727590373 GO:0071714 icosanoid transmembrane transporter activity 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.386865727590373 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.386865727590373 GO:0019887 protein kinase regulator activity 15/755 255/18639 0.0588235294117647 1.45220101285547 0.0957701129762215 0.387660761655923 GO:0015294 solute:monoatomic cation symporter activity 8/755 116/18639 0.0689655172413793 1.70258049783055 0.0988281336706106 0.398307326611855 GO:0046332 SMAD binding 6/755 79/18639 0.0759493670886076 1.87499371280074 0.10069529064115 0.403213900424061 GO:0001223 transcription coactivator binding 4/755 44/18639 0.0909090909090909 2.24431065623119 0.101594469165029 0.403213900424061 GO:0019205 nucleobase-containing compound kinase activity 4/755 44/18639 0.0909090909090909 2.24431065623119 0.101594469165029 0.403213900424061 GO:0004252 serine-type endopeptidase activity 11/755 176/18639 0.0625 1.54296357615894 0.102460022571728 0.403213900424061 GO:0005242 inward rectifier potassium channel activity 3/755 28/18639 0.107142857142857 2.64508041627247 0.102644140064986 0.403213900424061 GO:0097718 disordered domain specific binding 3/755 28/18639 0.107142857142857 2.64508041627247 0.102644140064986 0.403213900424061 GO:0046915 transition metal ion transmembrane transporter activity 4/755 45/18639 0.0888888888888889 2.19443708609272 0.108133927916183 0.417764313050394 GO:0140303 intramembrane lipid transporter activity 4/755 45/18639 0.0888888888888889 2.19443708609272 0.108133927916183 0.417764313050394 GO:0005545 1-phosphatidylinositol binding 2/755 14/18639 0.142857142857143 3.52677388836329 0.108143071369651 0.417764313050394 GO:1990825 sequence-specific mRNA binding 2/755 14/18639 0.142857142857143 3.52677388836329 0.108143071369651 0.417764313050394 GO:0004181 metallocarboxypeptidase activity 3/755 29/18639 0.103448275862069 2.55387074674583 0.11121450531239 0.423133604513112 GO:0043236 laminin binding 3/755 29/18639 0.103448275862069 2.55387074674583 0.11121450531239 0.423133604513112 GO:0051861 glycolipid binding 3/755 29/18639 0.103448275862069 2.55387074674583 0.11121450531239 0.423133604513112 GO:0005507 copper ion binding 5/755 63/18639 0.0793650793650794 1.9593188268685 0.111350948556082 0.423133604513112 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 19/755 349/18639 0.0544412607449857 1.34401411791495 0.118364204814806 0.44629221015159 GO:0004866 endopeptidase inhibitor activity 10/755 161/18639 0.062111801242236 1.5333799514623 0.119074596376853 0.44629221015159 GO:0004953 icosanoid receptor activity 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.44629221015159 GO:0008252 nucleotidase activity 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.44629221015159 GO:0015929 hexosaminidase activity 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.44629221015159 GO:0033130 acetylcholine receptor binding 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.44629221015159 GO:0048531 beta-1,3-galactosyltransferase activity 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.44629221015159 GO:0005504 fatty acid binding 4/755 47/18639 0.0851063829787234 2.10105678455685 0.121759636281959 0.44629221015159 GO:0140359 ABC-type transporter activity 4/755 47/18639 0.0851063829787234 2.10105678455685 0.121759636281959 0.44629221015159 GO:0019207 kinase regulator activity 16/755 287/18639 0.0557491289198606 1.37630200521494 0.12345084355011 0.450716609196675 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.484558223640804 GO:0015378 sodium:chloride symporter activity 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.484558223640804 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.484558223640804 GO:0070411 I-SMAD binding 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.484558223640804 GO:0140328 floppase activity 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.484558223640804 GO:0015399 primary active transmembrane transporter activity 10/755 166/18639 0.0602409638554217 1.48719380834597 0.137287283564024 0.484558223640804 GO:0015106 bicarbonate transmembrane transporter activity 3/755 32/18639 0.09375 2.31444536423841 0.138445206754515 0.484558223640804 GO:0043425 bHLH transcription factor binding 3/755 32/18639 0.09375 2.31444536423841 0.138445206754515 0.484558223640804 GO:0051059 NF-kappaB binding 3/755 32/18639 0.09375 2.31444536423841 0.138445206754515 0.484558223640804 GO:0071813 lipoprotein particle binding 3/755 32/18639 0.09375 2.31444536423841 0.138445206754515 0.484558223640804 GO:0071814 protein-lipid complex binding 3/755 32/18639 0.09375 2.31444536423841 0.138445206754515 0.484558223640804 GO:0032934 sterol binding 5/755 68/18639 0.0735294117647059 1.81525126606934 0.140953539806456 0.489770084779374 GO:0008081 phosphoric diester hydrolase activity 6/755 87/18639 0.0689655172413793 1.70258049783055 0.140986447605663 0.489770084779374 GO:0019239 deaminase activity 3/755 33/18639 0.0909090909090909 2.24431065623119 0.147980391072758 0.504215094177952 GO:0030414 peptidase inhibitor activity 10/755 169/18639 0.0591715976331361 1.46079391825698 0.148880046340824 0.504215094177952 GO:0004549 tRNA-specific ribonuclease activity 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.504215094177952 GO:0005092 GDP-dissociation inhibitor activity 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.504215094177952 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.504215094177952 GO:0030169 low-density lipoprotein particle binding 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.504215094177952 GO:0048038 quinone binding 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.504215094177952 GO:0070403 NAD+ binding 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.504215094177952 GO:0016597 amino acid binding 4/755 51/18639 0.0784313725490196 1.93626801714063 0.151035421050495 0.507631685913396 GO:0019842 vitamin binding 9/755 150/18639 0.06 1.48124503311258 0.155611873474318 0.521131849656798 GO:0016798 hydrolase activity, acting on glycosyl bonds 8/755 130/18639 0.0615384615384615 1.51922567498726 0.157684445312271 0.526179994930912 GO:0005080 protein kinase C binding 4/755 52/18639 0.0769230769230769 1.89903209373408 0.158740060772518 0.527810702068622 GO:1902936 phosphatidylinositol bisphosphate binding 7/755 111/18639 0.0630630630630631 1.55686414891713 0.163844874977543 0.529743646635038 GO:0008525 phosphatidylcholine transporter activity 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.529743646635038 GO:0015373 monoatomic anion:sodium symporter activity 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.529743646635038 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.529743646635038 GO:0017128 phospholipid scramblase activity 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.529743646635038 GO:0030228 lipoprotein particle receptor activity 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.529743646635038 GO:0034185 apolipoprotein binding 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.529743646635038 GO:0070064 proline-rich region binding 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.529743646635038 GO:0031625 ubiquitin protein ligase binding 16/755 302/18639 0.0529801324503311 1.307942634095 0.166757559009074 0.534531335806164 GO:0005179 hormone activity 8/755 132/18639 0.0606060606060606 1.49620710415412 0.167218805495405 0.534531335806164 GO:0005154 epidermal growth factor receptor binding 3/755 35/18639 0.0857142857142857 2.11606433301798 0.167651074173362 0.534531335806164 GO:0061631 ubiquitin conjugating enzyme activity 3/755 35/18639 0.0857142857142857 2.11606433301798 0.167651074173362 0.534531335806164 GO:0005506 iron ion binding 9/755 154/18639 0.0584415584415584 1.44277113614862 0.173356770552288 0.549653712230558 GO:0004521 RNA endonuclease activity 5/755 73/18639 0.0684931506849315 1.69091898757144 0.17357485649386 0.549653712230558 GO:0016409 palmitoyltransferase activity 3/755 36/18639 0.0833333333333333 2.05728476821192 0.177757764839654 0.55210467688022 GO:0005229 intracellularly calcium-gated chloride channel activity 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.55210467688022 GO:0005520 insulin-like growth factor binding 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.55210467688022 GO:0034987 immunoglobulin receptor binding 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.55210467688022 GO:0042577 lipid phosphatase activity 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.55210467688022 GO:0070003 threonine-type peptidase activity 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.55210467688022 GO:0141147 intracellularly calcium-gated channel activity 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.55210467688022 GO:0016779 nucleotidyltransferase activity 8/755 136/18639 0.0588235294117647 1.45220101285547 0.18704791797303 0.575710647649511 GO:0044183 protein folding chaperone 5/755 75/18639 0.0666666666666667 1.64582781456954 0.187368771469175 0.575710647649511 GO:0030280 structural constituent of skin epidermis 3/755 37/18639 0.0810810810810811 2.00168247717917 0.18802638574998 0.575830806359314 GO:0005109 frizzled binding 3/755 38/18639 0.0789473684210526 1.94900662251656 0.19844294722605 0.605738963499844 GO:0042626 ATPase-coupled transmembrane transporter activity 6/755 98/18639 0.0612244897959184 1.51147452358427 0.206339231591777 0.627783740561911 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/755 21/18639 0.0952380952380952 2.35118259224219 0.208278637307029 0.631620232354541 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/755 39/18639 0.0769230769230769 1.89903209373408 0.208993690943356 0.631730929442418 GO:0061135 endopeptidase regulator activity 10/755 184/18639 0.0543478260869565 1.34170745752951 0.213684462874411 0.643819530537464 GO:0033293 monocarboxylic acid binding 5/755 79/18639 0.0632911392405063 1.56249476066728 0.21606297132927 0.64888589131468 GO:1901981 phosphatidylinositol phosphate binding 10/755 185/18639 0.0540540540540541 1.33445498478611 0.218370979056822 0.653708622192608 GO:0004177 aminopeptidase activity 3/755 40/18639 0.075 1.85155629139073 0.219665119715215 0.655475084791234 GO:0042578 phosphoric ester hydrolase activity 18/755 363/18639 0.0495867768595041 1.22416944885337 0.220775245018109 0.655940519528014 GO:0033691 sialic acid binding 2/755 22/18639 0.0909090909090909 2.24431065623119 0.223355196717589 0.655940519528014 GO:0005085 guanyl-nucleotide exchange factor activity 12/755 230/18639 0.0521739130434783 1.28803915922833 0.223964058151702 0.655940519528014 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/755 122/18639 0.0573770491803279 1.41649115188362 0.22561333153127 0.655940519528014 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/755 41/18639 0.0731707317073171 1.80639638184461 0.230444023464503 0.655940519528014 GO:0042169 SH2 domain binding 3/755 41/18639 0.0731707317073171 1.80639638184461 0.230444023464503 0.655940519528014 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/755 41/18639 0.0731707317073171 1.80639638184461 0.230444023464503 0.655940519528014 GO:0033192 calmodulin-dependent protein phosphatase activity 5/755 81/18639 0.0617283950617284 1.52391464311994 0.230898225765777 0.655940519528014 GO:0140791 histone H2AXS140 phosphatase activity 5/755 81/18639 0.0617283950617284 1.52391464311994 0.230898225765777 0.655940519528014 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/755 81/18639 0.0617283950617284 1.52391464311994 0.230898225765777 0.655940519528014 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/755 81/18639 0.0617283950617284 1.52391464311994 0.230898225765777 0.655940519528014 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/755 81/18639 0.0617283950617284 1.52391464311994 0.230898225765777 0.655940519528014 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/755 81/18639 0.0617283950617284 1.52391464311994 0.230898225765777 0.655940519528014 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/755 81/18639 0.0617283950617284 1.52391464311994 0.230898225765777 0.655940519528014 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/755 81/18639 0.0617283950617284 1.52391464311994 0.230898225765777 0.655940519528014 GO:0022804 active transmembrane transporter activity 22/755 457/18639 0.0481400437636762 1.18845334531279 0.231093974656486 0.655940519528014 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/755 82/18639 0.0609756097560976 1.50533031820384 0.238423433228374 0.668836146639766 GO:0033549 MAP kinase phosphatase activity 5/755 82/18639 0.0609756097560976 1.50533031820384 0.238423433228374 0.668836146639766 GO:0017134 fibroblast growth factor binding 2/755 23/18639 0.0869565217391304 2.14673193204722 0.238510849285072 0.668836146639766 GO:0099186 structural constituent of postsynapse 2/755 23/18639 0.0869565217391304 2.14673193204722 0.238510849285072 0.668836146639766 GO:0015293 symporter activity 8/755 146/18639 0.0547945205479452 1.35273519005715 0.240554338527673 0.670646549454521 GO:0004520 DNA endonuclease activity 3/755 42/18639 0.0714285714285714 1.76338694418165 0.24131750168342 0.670646549454521 GO:0008307 structural constituent of muscle 3/755 42/18639 0.0714285714285714 1.76338694418165 0.24131750168342 0.670646549454521 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5/755 83/18639 0.0602409638554217 1.48719380834597 0.24601481299763 0.6816660443476 GO:0008200 ion channel inhibitor activity 3/755 43/18639 0.0697674418604651 1.72237794547975 0.252272982661934 0.692692661449705 GO:0017018 myosin phosphatase activity 5/755 84/18639 0.0595238095238095 1.46948912015137 0.253668200880102 0.692692661449705 GO:0004806 triacylglycerol lipase activity 2/755 24/18639 0.0833333333333333 2.05728476821192 0.25371449791015 0.692692661449705 GO:0015295 solute:proton symporter activity 2/755 24/18639 0.0833333333333333 2.05728476821192 0.25371449791015 0.692692661449705 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/755 24/18639 0.0833333333333333 2.05728476821192 0.25371449791015 0.692692661449705 GO:0004519 endonuclease activity 7/755 127/18639 0.0551181102362205 1.36072378369922 0.256035303090429 0.696984991746167 GO:0008509 monoatomic anion transmembrane transporter activity 8/755 149/18639 0.0536912751677852 1.32549891106271 0.257538655269469 0.699033492874273 GO:0004536 DNA nuclease activity 4/755 64/18639 0.0625 1.54296357615894 0.260292219822304 0.704453653065596 GO:0016248 channel inhibitor activity 3/755 44/18639 0.0681818181818182 1.68323299217339 0.263298239747073 0.710523655665289 GO:0008483 transaminase activity 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.714318058815541 GO:0015271 outward rectifier potassium channel activity 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.714318058815541 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.714318058815541 GO:0019707 protein-cysteine S-acyltransferase activity 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.714318058815541 GO:0120020 cholesterol transfer activity 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.714318058815541 GO:0120013 lipid transfer activity 4/755 65/18639 0.0615384615384615 1.51922567498726 0.269307882539479 0.714318058815541 GO:0005496 steroid binding 6/755 108/18639 0.0555555555555556 1.37152317880795 0.27327276411048 0.721607593054461 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/755 45/18639 0.0666666666666667 1.64582781456954 0.274381404877851 0.721607593054461 GO:0141110 transporter inhibitor activity 3/755 45/18639 0.0666666666666667 1.64582781456954 0.274381404877851 0.721607593054461 GO:0008235 metalloexopeptidase activity 4/755 66/18639 0.0606060606060606 1.49620710415412 0.278377619441508 0.728778514774059 GO:0003774 cytoskeletal motor activity 8/755 153/18639 0.0522875816993464 1.29084534476042 0.280727854196406 0.728778514774059 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.728778514774059 GO:0019865 immunoglobulin binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.728778514774059 GO:0050681 nuclear androgen receptor binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.728778514774059 GO:0050750 low-density lipoprotein particle receptor binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.728778514774059 GO:0070006 metalloaminopeptidase activity 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.728778514774059 GO:0070412 R-SMAD binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.728778514774059 GO:0120014 phospholipid transfer activity 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.728778514774059 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 7/755 132/18639 0.053030303030303 1.30918121613486 0.287565839690765 0.735504936132148 GO:0008514 organic anion transmembrane transporter activity 13/755 269/18639 0.0483271375464684 1.19307220758758 0.296570307099512 0.75460321174333 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/755 68/18639 0.0588235294117647 1.45220101285547 0.2966538941977 0.75460321174333 GO:0016405 CoA-ligase activity 2/755 27/18639 0.0740740740740741 1.82869757174393 0.299337355683711 0.7552386941505 GO:0023026 MHC class II protein complex binding 2/755 27/18639 0.0740740740740741 1.82869757174393 0.299337355683711 0.7552386941505 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/755 27/18639 0.0740740740740741 1.82869757174393 0.299337355683711 0.7552386941505 GO:0005200 structural constituent of cytoskeleton 6/755 112/18639 0.0535714285714286 1.32254020813623 0.30140315934742 0.755711248076798 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/755 48/18639 0.0625 1.54296357615894 0.307865262849596 0.755711248076798 GO:0016866 intramolecular transferase activity 2/755 28/18639 0.0714285714285714 1.76338694418165 0.314467603038997 0.755711248076798 GO:0046875 ephrin receptor binding 2/755 28/18639 0.0714285714285714 1.76338694418165 0.314467603038997 0.755711248076798 GO:0046966 nuclear thyroid hormone receptor binding 2/755 28/18639 0.0714285714285714 1.76338694418165 0.314467603038997 0.755711248076798 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/755 70/18639 0.0571428571428571 1.41070955534532 0.315071258393766 0.755711248076798 GO:0097110 scaffold protein binding 4/755 70/18639 0.0571428571428571 1.41070955534532 0.315071258393766 0.755711248076798 GO:0015079 potassium ion transmembrane transporter activity 8/755 160/18639 0.05 1.23437086092715 0.322505372783205 0.755711248076798 GO:0051219 phosphoprotein binding 5/755 93/18639 0.0537634408602151 1.32728049562059 0.324659049397415 0.755711248076798 GO:0016417 S-acyltransferase activity 2/755 29/18639 0.0689655172413793 1.70258049783055 0.329523388055783 0.755711248076798 GO:0009055 electron transfer activity 6/755 116/18639 0.0517241379310345 1.27693537337292 0.330034161542707 0.755711248076798 GO:0042562 hormone binding 5/755 94/18639 0.0531914893617021 1.31316049034803 0.332707406965606 0.755711248076798 GO:0070851 growth factor receptor binding 7/755 139/18639 0.0503597122302158 1.2432512268331 0.333063272224591 0.755711248076798 GO:1990782 protein tyrosine kinase binding 6/755 117/18639 0.0512820512820513 1.26602139582272 0.337249004598877 0.755711248076798 GO:0004090 carbonyl reductase (NADPH) activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0005345 purine nucleobase transmembrane transporter activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0005381 iron ion transmembrane transporter activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0008239 dipeptidyl-peptidase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0008401 retinoic acid 4-hydroxylase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0015279 store-operated calcium channel activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0016427 tRNA (cytidine) methyltransferase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0016868 intramolecular phosphotransferase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0030957 Tat protein binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0033204 ribonuclease P RNA binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0035256 G protein-coupled glutamate receptor binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0043121 neurotrophin binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0043295 glutathione binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0050815 phosphoserine residue binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0070513 death domain binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0140999 histone H3K4 trimethyltransferase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0141109 transporter activator activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:1990757 ubiquitin ligase activator activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.755711248076798 GO:0022853 active monoatomic ion transmembrane transporter activity 6/755 118/18639 0.0508474576271186 1.25529240094287 0.344481157318597 0.755711248076798 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/755 30/18639 0.0666666666666667 1.64582781456954 0.344485933995557 0.755711248076798 GO:0016769 transferase activity, transferring nitrogenous groups 2/755 30/18639 0.0666666666666667 1.64582781456954 0.344485933995557 0.755711248076798 GO:0033612 receptor serine/threonine kinase binding 2/755 30/18639 0.0666666666666667 1.64582781456954 0.344485933995557 0.755711248076798 GO:0098918 structural constituent of synapse 2/755 30/18639 0.0666666666666667 1.64582781456954 0.344485933995557 0.755711248076798 GO:0019001 guanyl nucleotide binding 18/755 400/18639 0.045 1.11093377483444 0.357215840588865 0.755711248076798 GO:0032561 guanyl ribonucleotide binding 18/755 400/18639 0.045 1.11093377483444 0.357215840588865 0.755711248076798 GO:0005164 tumor necrosis factor receptor binding 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.755711248076798 GO:0008327 methyl-CpG binding 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.755711248076798 GO:0016878 acid-thiol ligase activity 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.755711248076798 GO:0017147 Wnt-protein binding 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.755711248076798 GO:0047499 calcium-independent phospholipase A2 activity 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.755711248076798 GO:0070325 lipoprotein particle receptor binding 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.755711248076798 GO:0022843 voltage-gated monoatomic cation channel activity 7/755 143/18639 0.048951048951049 1.20847496873987 0.359521738158006 0.755711248076798 GO:0004864 protein phosphatase inhibitor activity 3/755 53/18639 0.0566037735849057 1.39740097463451 0.363832367711558 0.755711248076798 GO:0017046 peptide hormone binding 3/755 53/18639 0.0566037735849057 1.39740097463451 0.363832367711558 0.755711248076798 GO:0005525 GTP binding 17/755 378/18639 0.044973544973545 1.11028066855881 0.36389322032008 0.755711248076798 GO:0005249 voltage-gated potassium channel activity 5/755 98/18639 0.0510204081632653 1.25956210298689 0.365041004538192 0.755711248076798 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0008172 S-methyltransferase activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0008199 ferric iron binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0008503 benzodiazepine receptor activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0008526 phosphatidylinositol transfer activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0010854 adenylate cyclase regulator activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0015173 aromatic amino acid transmembrane transporter activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0015205 nucleobase transmembrane transporter activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0019206 nucleoside kinase activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0019215 intermediate filament binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0032050 clathrin heavy chain binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0032794 GTPase activating protein binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0034511 U3 snoRNA binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0042608 T cell receptor binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0047676 arachidonate-CoA ligase activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0048407 platelet-derived growth factor binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0050786 RAGE receptor binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0070697 activin receptor binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0140031 phosphorylation-dependent protein binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:1900750 oligopeptide binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.755711248076798 GO:0004540 RNA nuclease activity 6/755 121/18639 0.0495867768595041 1.22416944885337 0.366254462147536 0.755711248076798 GO:0015108 chloride transmembrane transporter activity 6/755 121/18639 0.0495867768595041 1.22416944885337 0.366254462147536 0.755711248076798 GO:0051082 unfolded protein binding 6/755 121/18639 0.0495867768595041 1.22416944885337 0.366254462147536 0.755711248076798 GO:0098631 cell adhesion mediator activity 4/755 76/18639 0.0526315789473684 1.29933774834437 0.370700871520446 0.755711248076798 GO:0022884 macromolecule transmembrane transporter activity 2/755 32/18639 0.0625 1.54296357615894 0.374064296541417 0.755711248076798 GO:0031369 translation initiation factor binding 2/755 32/18639 0.0625 1.54296357615894 0.374064296541417 0.755711248076798 GO:0120015 sterol transfer activity 2/755 32/18639 0.0625 1.54296357615894 0.374064296541417 0.755711248076798 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/755 54/18639 0.0555555555555556 1.37152317880795 0.374965639471915 0.755711248076798 GO:0051287 NAD binding 3/755 54/18639 0.0555555555555556 1.37152317880795 0.374965639471915 0.755711248076798 GO:0043130 ubiquitin binding 5/755 100/18639 0.05 1.23437086092715 0.381240818779381 0.755711248076798 GO:0004032 aldose reductase (NADPH) activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0004126 cytidine deaminase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0004526 ribonuclease P activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0004859 phospholipase inhibitor activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0005025 transforming growth factor beta receptor activity, type I 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0005026 transforming growth factor beta receptor activity, type II 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0005078 MAP-kinase scaffold activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0005095 GTPase inhibitor activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0008504 monoamine transmembrane transporter activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0016361 activin receptor activity, type I 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0016362 activin receptor activity, type II 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0016423 tRNA (guanine) methyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0016840 carbon-nitrogen lyase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0017002 activin receptor activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0035259 nuclear glucocorticoid receptor binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0070410 co-SMAD binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0070679 inositol 1,4,5 trisphosphate binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:1990459 transferrin receptor binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.755711248076798 GO:0019212 phosphatase inhibitor activity 3/755 56/18639 0.0535714285714286 1.32254020813623 0.397105755526475 0.763368970482621 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/755 34/18639 0.0588235294117647 1.45220101285547 0.40308347083957 0.763368970482621 GO:0016831 carboxy-lyase activity 2/755 34/18639 0.0588235294117647 1.45220101285547 0.40308347083957 0.763368970482621 GO:0019825 oxygen binding 2/755 34/18639 0.0588235294117647 1.45220101285547 0.40308347083957 0.763368970482621 GO:0030332 cyclin binding 2/755 34/18639 0.0588235294117647 1.45220101285547 0.40308347083957 0.763368970482621 GO:0004722 protein serine/threonine phosphatase activity 5/755 103/18639 0.0485436893203883 1.19841831157976 0.40550353442461 0.763368970482621 GO:0048306 calcium-dependent protein binding 4/755 80/18639 0.05 1.23437086092715 0.407671016070025 0.763368970482621 GO:0003823 antigen binding 8/755 174/18639 0.0459770114942529 1.13505366522037 0.408589632492209 0.763368970482621 GO:0022832 voltage-gated channel activity 8/755 175/18639 0.0457142857142857 1.12856764427625 0.414778367876495 0.763368970482621 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0005172 vascular endothelial growth factor receptor binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0005542 folic acid binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0009982 pseudouridine synthase activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0017154 semaphorin receptor activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0019104 DNA N-glycosylase activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0031994 insulin-like growth factor I binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0035325 Toll-like receptor binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0035673 oligopeptide transmembrane transporter activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0046975 histone H3K36 methyltransferase activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0061459 L-arginine transmembrane transporter activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0070123 transforming growth factor beta receptor activity, type III 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0070700 BMP receptor binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0140333 glycerophospholipid flippase activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0140852 histone ubiquitin ligase activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.763368970482621 GO:0030971 receptor tyrosine kinase binding 4/755 81/18639 0.0493827160493827 1.21913171449595 0.416854018163752 0.763368970482621 GO:0004623 phospholipase A2 activity 2/755 35/18639 0.0571428571428571 1.41070955534532 0.417352100940552 0.763368970482621 GO:0030695 GTPase regulator activity 21/755 489/18639 0.0429447852760736 1.06019583147117 0.423169670847889 0.770746385753689 GO:0060589 nucleoside-triphosphatase regulator activity 21/755 490/18639 0.0428571428571429 1.05803216650899 0.426888913865019 0.770746385753689 GO:0016791 phosphatase activity 12/755 273/18639 0.043956043956044 1.08516119641947 0.427830798541353 0.770746385753689 GO:0000149 SNARE binding 5/755 106/18639 0.0471698113207547 1.16450081219543 0.429643665775288 0.770746385753689 GO:0004497 monooxygenase activity 5/755 106/18639 0.0471698113207547 1.16450081219543 0.429643665775288 0.770746385753689 GO:0045309 protein phosphorylated amino acid binding 3/755 59/18639 0.0508474576271186 1.25529240094287 0.42989135975868 0.770746385753689 GO:0070063 RNA polymerase binding 3/755 59/18639 0.0508474576271186 1.25529240094287 0.42989135975868 0.770746385753689 GO:0004033 aldo-keto reductase (NADPH) activity 2/755 36/18639 0.0555555555555556 1.37152317880795 0.431445885417076 0.770746385753689 GO:0045505 dynein intermediate chain binding 2/755 36/18639 0.0555555555555556 1.37152317880795 0.431445885417076 0.770746385753689 GO:0030165 PDZ domain binding 4/755 83/18639 0.0481927710843374 1.18975504667677 0.435117696549077 0.770746385753689 GO:0004065 arylsulfatase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0004705 JUN kinase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0005344 oxygen carrier activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0008195 phosphatidate phosphatase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0031404 chloride ion binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0042043 neurexin family protein binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0044548 S100 protein binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0070742 C2H2 zinc finger domain binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0098821 BMP receptor activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:1901474 azole transmembrane transporter activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.770746385753689 GO:0051117 ATPase binding 4/755 84/18639 0.0476190476190476 1.1755912961211 0.444190171332526 0.777332799831921 GO:0003714 transcription corepressor activity 9/755 204/18639 0.0441176470588235 1.08915075964161 0.445074772990458 0.777419537812601 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 10/755 229/18639 0.0436681222707424 1.07805315364817 0.449835596394941 0.778328757797025 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/755 61/18639 0.0491803278688525 1.2141352730431 0.451389577520888 0.778328757797025 GO:0000287 magnesium ion binding 10/755 230/18639 0.0434782608695652 1.07336596602361 0.455291438112178 0.778328757797025 GO:0000146 microfilament motor activity 2/755 38/18639 0.0526315789473684 1.29933774834437 0.459072939106021 0.778328757797025 GO:0043531 ADP binding 2/755 38/18639 0.0526315789473684 1.29933774834437 0.459072939106021 0.778328757797025 GO:0046873 metal ion transmembrane transporter activity 19/755 450/18639 0.0422222222222222 1.04235761589404 0.459723880626168 0.778328757797025 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/755 86/18639 0.0465116279069767 1.14825196365316 0.46219705633505 0.778328757797025 GO:0050660 flavin adenine dinucleotide binding 4/755 86/18639 0.0465116279069767 1.14825196365316 0.46219705633505 0.778328757797025 GO:0000774 adenyl-nucleotide exchange factor activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0004467 long-chain fatty acid-CoA ligase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0005041 low-density lipoprotein particle receptor activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0010181 FMN binding 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0017081 chloride channel regulator activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0030553 cGMP binding 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0031005 filamin binding 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0050780 dopamine receptor binding 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.778328757797025 GO:0004518 nuclease activity 9/755 209/18639 0.0430622009569378 1.06309452137267 0.473853373631445 0.790717597451176 GO:0140789 histone phosphatase activity 6/755 136/18639 0.0441176470588235 1.08915075964161 0.474699603113229 0.790717597451176 GO:0005125 cytokine activity 10/755 234/18639 0.0427350427350427 1.05501782985227 0.477029238532488 0.790717597451176 GO:0043022 ribosome binding 5/755 112/18639 0.0446428571428571 1.10211684011353 0.477234462819975 0.790717597451176 GO:0004197 cysteine-type endopeptidase activity 4/755 88/18639 0.0454545454545455 1.12215532811559 0.479995880273362 0.790717597451176 GO:0035091 phosphatidylinositol binding 12/755 284/18639 0.0422535211267606 1.04313030500886 0.482309094086018 0.790717597451176 GO:0000062 fatty-acyl-CoA binding 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0004707 MAP kinase activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0008142 oxysterol binding 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0008296 3'-5'-DNA exonuclease activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0016722 oxidoreductase activity, acting on metal ions 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0019841 retinol binding 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0055102 lipase inhibitor activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0097027 ubiquitin-protein transferase activator activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0140327 flippase activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.790717597451176 GO:0030331 nuclear estrogen receptor binding 2/755 40/18639 0.05 1.23437086092715 0.485902610861308 0.790865962783003 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/755 40/18639 0.05 1.23437086092715 0.485902610861308 0.790865962783003 GO:0140767 enzyme-substrate adaptor activity 6/755 139/18639 0.0431654676258993 1.06564390871409 0.495874713955487 0.797488001076196 GO:0015291 secondary active transmembrane transporter activity 12/755 287/18639 0.0418118466898955 1.03222650391121 0.497019153412222 0.797488001076196 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/755 41/18639 0.0487804878048781 1.20426425456308 0.499003051240631 0.797488001076196 GO:0017080 sodium channel regulator activity 2/755 41/18639 0.0487804878048781 1.20426425456308 0.499003051240631 0.797488001076196 GO:0015103 inorganic anion transmembrane transporter activity 7/755 165/18639 0.0424242424242424 1.04734497290789 0.504801771419445 0.797488001076196 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0008429 phosphatidylethanolamine binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0008484 sulfuric ester hydrolase activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0016805 dipeptidase activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0019198 transmembrane receptor protein phosphatase activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0032977 membrane insertase activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0045125 bioactive lipid receptor activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0046965 nuclear retinoid X receptor binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0051787 misfolded protein binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0070402 NADPH binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:1901567 fatty acid derivative binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.797488001076196 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/755 91/18639 0.043956043956044 1.08516119641947 0.506246410994664 0.797488001076196 GO:0072341 modified amino acid binding 4/755 91/18639 0.043956043956044 1.08516119641947 0.506246410994664 0.797488001076196 GO:0019894 kinesin binding 2/755 42/18639 0.0476190476190476 1.1755912961211 0.511887328718491 0.802206053198475 GO:0031492 nucleosomal DNA binding 2/755 42/18639 0.0476190476190476 1.1755912961211 0.511887328718491 0.802206053198475 GO:0043175 RNA polymerase core enzyme binding 2/755 42/18639 0.0476190476190476 1.1755912961211 0.511887328718491 0.802206053198475 GO:0051020 GTPase binding 13/755 315/18639 0.0412698412698413 1.01884578997162 0.512688079111807 0.802206053198475 GO:0019208 phosphatase regulator activity 5/755 117/18639 0.0427350427350427 1.05501782985227 0.515854248165114 0.805376998957407 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/755 43/18639 0.0465116279069767 1.14825196365316 0.524551443160275 0.805376998957407 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/755 43/18639 0.0465116279069767 1.14825196365316 0.524551443160275 0.805376998957407 GO:0000400 four-way junction DNA binding 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:0000900 mRNA regulatory element binding translation repressor activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:0004970 glutamate-gated receptor activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:0031690 adrenergic receptor binding 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:0032393 MHC class I receptor activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:0035615 clathrin adaptor activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:0050811 GABA receptor binding 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:1990381 ubiquitin-specific protease binding 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.805376998957407 GO:0046982 protein heterodimerization activity 15/755 369/18639 0.040650406504065 1.00355354546923 0.531866164846418 0.814420064921077 GO:0001046 core promoter sequence-specific DNA binding 2/755 44/18639 0.0454545454545455 1.12215532811559 0.536992071894236 0.816087799358994 GO:0016790 thiolester hydrolase activity 2/755 44/18639 0.0454545454545455 1.12215532811559 0.536992071894236 0.816087799358994 GO:0043014 alpha-tubulin binding 2/755 44/18639 0.0454545454545455 1.12215532811559 0.536992071894236 0.816087799358994 GO:0032182 ubiquitin-like protein binding 5/755 120/18639 0.0416666666666667 1.02864238410596 0.538445698957586 0.816087799358994 GO:0016782 transferase activity, transferring sulphur-containing groups 3/755 70/18639 0.0428571428571429 1.05803216650899 0.543394213152546 0.816087799358994 GO:0008301 DNA binding, bending 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.816087799358994 GO:0008381 mechanosensitive monoatomic ion channel activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.816087799358994 GO:0008574 plus-end-directed microtubule motor activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.816087799358994 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.816087799358994 GO:0016918 retinal binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.816087799358994 GO:0042800 histone H3K4 methyltransferase activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.816087799358994 GO:0046527 glucosyltransferase activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.816087799358994 GO:0120227 acyl-CoA binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.816087799358994 GO:0001664 G protein-coupled receptor binding 12/755 297/18639 0.0404040404040404 0.997471402769416 0.545241982872641 0.816109784653423 GO:0140299 molecular sensor activity 3/755 71/18639 0.0422535211267606 1.04313030500886 0.553059349428702 0.825416003301991 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 5/755 122/18639 0.040983606557377 1.01177939420258 0.553232638088553 0.825416003301991 GO:0005244 voltage-gated monoatomic ion channel activity 7/755 173/18639 0.0404624277456647 0.998912835432378 0.555217612173123 0.826484674443169 GO:0030276 clathrin binding 2/755 46/18639 0.0434782608695652 1.07336596602361 0.561192682518302 0.826484674443169 GO:0005326 neurotransmitter transmembrane transporter activity 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.826484674443169 GO:0015095 magnesium ion transmembrane transporter activity 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.826484674443169 GO:0016004 phospholipase activator activity 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.826484674443169 GO:0016408 C-acyltransferase activity 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.826484674443169 GO:0016505 peptidase activator activity involved in apoptotic process 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.826484674443169 GO:0030742 GTP-dependent protein binding 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.826484674443169 GO:0052745 inositol phosphate phosphatase activity 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.826484674443169 GO:0140939 histone H4 methyltransferase activity 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.826484674443169 GO:0005267 potassium channel activity 5/755 124/18639 0.0403225806451613 0.995460371715445 0.567784627714924 0.832452737641881 GO:0001784 phosphotyrosine residue binding 2/755 47/18639 0.0425531914893617 1.05052839227843 0.572948986454982 0.834097958657679 GO:0099095 ligand-gated monoatomic anion channel activity 2/755 47/18639 0.0425531914893617 1.05052839227843 0.572948986454982 0.834097958657679 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0010314 phosphatidylinositol-5-phosphate binding 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0015174 basic amino acid transmembrane transporter activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0019200 carbohydrate kinase activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0035613 RNA stem-loop binding 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0036122 BMP binding 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0051010 microtubule plus-end binding 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0061891 calcium ion sensor activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0140312 cargo adaptor activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:1904047 S-adenosyl-L-methionine binding 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.834097958657679 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/755 48/18639 0.0416666666666667 1.02864238410596 0.584474365742172 0.837147130009173 GO:0038187 pattern recognition receptor activity 2/755 48/18639 0.0416666666666667 1.02864238410596 0.584474365742172 0.837147130009173 GO:0140996 histone H3 kinase activity 14/755 357/18639 0.0392156862745098 0.968134008570316 0.588007104755105 0.840913386370204 GO:0042826 histone deacetylase binding 5/755 127/18639 0.0393700787401575 0.971945559785159 0.589146072799055 0.841249990453865 GO:0019003 GDP binding 3/755 75/18639 0.04 0.987496688741722 0.590472156974419 0.841852340188644 GO:0001222 transcription corepressor binding 2/755 49/18639 0.0408163265306122 1.00764968238951 0.595768215723112 0.842926176802294 GO:0035254 glutamate receptor binding 2/755 49/18639 0.0408163265306122 1.00764968238951 0.595768215723112 0.842926176802294 GO:0031490 chromatin DNA binding 5/755 128/18639 0.0390625 0.964352235099338 0.596136817060949 0.842926176802294 GO:0005243 gap junction channel activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.842926176802294 GO:0008970 phospholipase A1 activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.842926176802294 GO:0140517 protein-RNA adaptor activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.842926176802294 GO:0140784 metal ion sensor activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.842926176802294 GO:0031267 small GTPase binding 11/755 283/18639 0.03886925795053 0.959581587999906 0.598826657934247 0.843430587801489 GO:0035173 histone kinase activity 14/755 360/18639 0.0388888888888889 0.960066225165563 0.600636815627325 0.844702228623926 GO:0005516 calmodulin binding 8/755 207/18639 0.0386473429951691 0.954103080909876 0.604152071584405 0.847644708037067 GO:0005253 monoatomic anion channel activity 4/755 103/18639 0.0388349514563107 0.958734649263808 0.604550038814836 0.847644708037067 GO:0032813 tumor necrosis factor receptor superfamily binding 2/755 50/18639 0.04 0.987496688741722 0.606830359016315 0.849562502622841 GO:0005212 structural constituent of eye lens 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.854298529907217 GO:0008171 O-methyltransferase activity 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.854298529907217 GO:0016849 phosphorus-oxygen lyase activity 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.854298529907217 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.854298529907217 GO:0005262 calcium channel activity 5/755 131/18639 0.0381679389312977 0.942267832768819 0.616703545265758 0.855717860346871 GO:0005048 signal sequence binding 2/755 51/18639 0.0392156862745098 0.968134008570316 0.617661011979697 0.855717860346871 GO:0016830 carbon-carbon lyase activity 2/755 51/18639 0.0392156862745098 0.968134008570316 0.617661011979697 0.855717860346871 GO:0015078 proton transmembrane transporter activity 7/755 185/18639 0.0378378378378378 0.934118489350278 0.626234073515364 0.8568782734958 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/755 52/18639 0.0384615384615385 0.94951604686704 0.62826075318445 0.8568782734958 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0004622 lysophospholipase activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0005540 hyaluronic acid binding 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0030215 semaphorin receptor binding 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0048027 mRNA 5'-UTR binding 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0060229 lipase activator activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.8568782734958 GO:0019888 protein phosphatase regulator activity 4/755 107/18639 0.0373831775700935 0.922894101627777 0.634552297312171 0.857276055393909 GO:0005544 calcium-dependent phospholipid binding 2/755 53/18639 0.0377358490566038 0.931600649756341 0.63863049379123 0.857276055393909 GO:0008146 sulfotransferase activity 2/755 53/18639 0.0377358490566038 0.931600649756341 0.63863049379123 0.857276055393909 GO:0015101 organic cation transmembrane transporter activity 3/755 81/18639 0.037037037037037 0.914348785871965 0.642666538296782 0.857276055393909 GO:0046943 carboxylic acid transmembrane transporter activity 7/755 188/18639 0.0372340425531915 0.919212343243624 0.642969866312905 0.857276055393909 GO:0001848 complement binding 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0005537 D-mannose binding 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0015645 fatty acid ligase activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0015662 P-type ion transporter activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0019211 phosphatase activator activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0042974 nuclear retinoic acid receptor binding 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0047617 fatty acyl-CoA hydrolase activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0120515 fatty acid-CoA ligase activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0140358 P-type transmembrane transporter activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.857276055393909 GO:0005342 organic acid transmembrane transporter activity 7/755 189/18639 0.037037037037037 0.914348785871965 0.648450675345493 0.859183811800076 GO:0003925 G protein activity 2/755 54/18639 0.037037037037037 0.914348785871965 0.648771449726588 0.859183811800076 GO:0050661 NADP binding 2/755 54/18639 0.037037037037037 0.914348785871965 0.648771449726588 0.859183811800076 GO:0016922 nuclear receptor binding 5/755 137/18639 0.0364963503649635 0.90100062841398 0.655928189956519 0.861679515196197 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.861679515196197 GO:0004529 DNA exonuclease activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.861679515196197 GO:0005112 Notch binding 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.861679515196197 GO:0008066 glutamate receptor activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.861679515196197 GO:0016289 acyl-CoA hydrolase activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.861679515196197 GO:0030247 polysaccharide binding 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.861679515196197 GO:0051139 metal cation:proton antiporter activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.861679515196197 GO:0005254 chloride channel activity 3/755 83/18639 0.036144578313253 0.89231628500758 0.658985837615137 0.861679515196197 GO:0005096 GTPase activator activity 10/755 271/18639 0.03690036900369 0.910974805112289 0.663058252789016 0.865788546068126 GO:0004364 glutathione transferase activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.872414009950135 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.872414009950135 GO:0005104 fibroblast growth factor receptor binding 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.872414009950135 GO:0008320 protein transmembrane transporter activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.872414009950135 GO:0008395 steroid hydroxylase activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.872414009950135 GO:0141003 histone H2AX kinase activity 13/755 354/18639 0.0367231638418079 0.906600067347626 0.680730419058822 0.879820524314264 GO:0005126 cytokine receptor binding 10/755 275/18639 0.0363636363636364 0.897724262492474 0.680778747286472 0.879820524314264 GO:0004674 protein serine/threonine kinase activity 16/755 433/18639 0.0369515011547344 0.912237125858404 0.682758073137962 0.879820524314264 GO:0019789 SUMO transferase activity 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.879820524314264 GO:0045499 chemorepellent activity 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.879820524314264 GO:0051537 2 iron, 2 sulfur cluster binding 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.879820524314264 GO:0051959 dynein light intermediate chain binding 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.879820524314264 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.879820524314264 GO:0001221 transcription coregulator binding 4/755 115/18639 0.0347826086956522 0.858692772818889 0.689986340328974 0.883600113956362 GO:0001786 phosphatidylserine binding 2/755 59/18639 0.0338983050847458 0.836861600628578 0.696105191463121 0.887592820338754 GO:0070888 E-box binding 2/755 59/18639 0.0338983050847458 0.836861600628578 0.696105191463121 0.887592820338754 GO:0003785 actin monomer binding 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.887592820338754 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.887592820338754 GO:0097472 cyclin-dependent protein kinase activity 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.887592820338754 GO:0099604 ligand-gated calcium channel activity 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.887592820338754 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 3/755 89/18639 0.0337078651685393 0.832160130962125 0.70467858917165 0.892592879617424 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 3/755 89/18639 0.0337078651685393 0.832160130962125 0.70467858917165 0.892592879617424 GO:0031210 phosphatidylcholine binding 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.895547279682425 GO:0031624 ubiquitin conjugating enzyme binding 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.895547279682425 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.895547279682425 GO:0051721 protein phosphatase 2A binding 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.895547279682425 GO:0140793 histone H2AXY142 phosphatase activity 3/755 90/18639 0.0333333333333333 0.822913907284768 0.711820608984956 0.895547279682425 GO:0019905 syntaxin binding 2/755 61/18639 0.0327868852459016 0.809423515362067 0.713506957873406 0.896457459892228 GO:0015085 calcium ion transmembrane transporter activity 5/755 147/18639 0.0340136054421769 0.839708068657927 0.715336260504061 0.897544553273963 GO:0004721 phosphoprotein phosphatase activity 6/755 175/18639 0.0342857142857143 0.84642573320719 0.717065514367606 0.898503356495614 GO:0015179 L-amino acid transmembrane transporter activity 2/755 62/18639 0.032258064516129 0.796368297372356 0.72189006747398 0.90333286669123 GO:0005261 monoatomic cation channel activity 12/755 341/18639 0.0351906158357771 0.868765415315298 0.731230492215099 0.909943959835439 GO:0005216 monoatomic ion channel activity 16/755 448/18639 0.0357142857142857 0.881693472090823 0.732682141793247 0.909943959835439 GO:0008528 G protein-coupled peptide receptor activity 4/755 122/18639 0.0327868852459016 0.809423515362067 0.733376315318617 0.909943959835439 GO:0030515 snoRNA binding 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.909943959835439 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.909943959835439 GO:0042910 xenobiotic transmembrane transporter activity 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.909943959835439 GO:0047498 calcium-dependent phospholipase A2 activity 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.909943959835439 GO:0030296 protein tyrosine kinase activator activity 1/755 33/18639 0.0303030303030303 0.748103552077062 0.744807588484663 0.919335200659209 GO:0140416 transcription regulator inhibitor activity 1/755 33/18639 0.0303030303030303 0.748103552077062 0.744807588484663 0.919335200659209 GO:0022836 gated channel activity 11/755 318/18639 0.0345911949685535 0.853967262276646 0.745407192387881 0.919335200659209 GO:0008276 protein methyltransferase activity 3/755 95/18639 0.0315789473684211 0.779602649006623 0.745540361436845 0.919335200659209 GO:0016407 acetyltransferase activity 3/755 96/18639 0.03125 0.77148178807947 0.751892833786401 0.92507450935175 GO:0008175 tRNA methyltransferase activity 1/755 34/18639 0.0294117647058824 0.726100506427737 0.755162864776939 0.92507450935175 GO:0015020 glucuronosyltransferase activity 1/755 34/18639 0.0294117647058824 0.726100506427737 0.755162864776939 0.92507450935175 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/755 34/18639 0.0294117647058824 0.726100506427737 0.755162864776939 0.92507450935175 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/755 34/18639 0.0294117647058824 0.726100506427737 0.755162864776939 0.92507450935175 GO:0004725 protein tyrosine phosphatase activity 3/755 98/18639 0.0306122448979592 0.755737261792134 0.764215175123623 0.93211496779479 GO:0000175 3'-5'-RNA exonuclease activity 1/755 35/18639 0.0285714285714286 0.705354777672658 0.765098475478009 0.93211496779479 GO:0016229 steroid dehydrogenase activity 1/755 35/18639 0.0285714285714286 0.705354777672658 0.765098475478009 0.93211496779479 GO:0043015 gamma-tubulin binding 1/755 35/18639 0.0285714285714286 0.705354777672658 0.765098475478009 0.93211496779479 GO:0001653 peptide receptor activity 4/755 128/18639 0.03125 0.77148178807947 0.766799738874275 0.93211496779479 GO:0003777 microtubule motor activity 2/755 68/18639 0.0294117647058824 0.726100506427737 0.767932219570704 0.93211496779479 GO:1990841 promoter-specific chromatin binding 2/755 68/18639 0.0294117647058824 0.726100506427737 0.767932219570704 0.93211496779479 GO:0015276 ligand-gated monoatomic ion channel activity 6/755 186/18639 0.032258064516129 0.796368297372356 0.769304881307972 0.93211496779479 GO:0008234 cysteine-type peptidase activity 6/755 187/18639 0.0320855614973262 0.792109643375713 0.773676099856719 0.93211496779479 GO:0000993 RNA polymerase II complex binding 1/755 36/18639 0.0277777777777778 0.685761589403973 0.774631406622607 0.93211496779479 GO:0004190 aspartic-type endopeptidase activity 1/755 36/18639 0.0277777777777778 0.685761589403973 0.774631406622607 0.93211496779479 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/755 36/18639 0.0277777777777778 0.685761589403973 0.774631406622607 0.93211496779479 GO:0055106 ubiquitin-protein transferase regulator activity 1/755 36/18639 0.0277777777777778 0.685761589403973 0.774631406622607 0.93211496779479 GO:0002039 p53 binding 2/755 69/18639 0.0289855072463768 0.715577310682407 0.774926944224669 0.93211496779479 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4/755 130/18639 0.0307692307692308 0.759612837493632 0.77718614329583 0.933381604257519 GO:0022834 ligand-gated channel activity 6/755 188/18639 0.0319148936170213 0.787896294208821 0.777985096566954 0.933381604257519 GO:0022829 wide pore channel activity 1/755 37/18639 0.027027027027027 0.667227492393055 0.783777957609004 0.935509331453824 GO:0030551 cyclic nucleotide binding 1/755 37/18639 0.027027027027027 0.667227492393055 0.783777957609004 0.935509331453824 GO:0042805 actinin binding 1/755 37/18639 0.027027027027027 0.667227492393055 0.783777957609004 0.935509331453824 GO:0070001 aspartic-type peptidase activity 1/755 37/18639 0.027027027027027 0.667227492393055 0.783777957609004 0.935509331453824 GO:0019902 phosphatase binding 6/755 190/18639 0.0315789473684211 0.779602649006623 0.786417466947115 0.937388041310181 GO:0015171 amino acid transmembrane transporter activity 3/755 102/18639 0.0294117647058824 0.726100506427737 0.787365680241205 0.937388041310181 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/755 38/18639 0.0263157894736842 0.649668874172185 0.792553768919895 0.941157600592375 GO:0042887 amide transmembrane transporter activity 1/755 38/18639 0.0263157894736842 0.649668874172185 0.792553768919895 0.941157600592375 GO:0005543 phospholipid binding 17/755 497/18639 0.03420523138833 0.844438818340507 0.796182867690165 0.943862162619848 GO:0051087 protein-folding chaperone binding 4/755 134/18639 0.0298507462686567 0.736937827419195 0.796858925691944 0.943862162619848 GO:0001217 DNA-binding transcription repressor activity 9/755 278/18639 0.0323741007194245 0.799232931535566 0.797911870589073 0.943908451738789 GO:0000217 DNA secondary structure binding 1/755 39/18639 0.0256410256410256 0.63301069791136 0.800973848725576 0.946328240055218 GO:0099094 ligand-gated monoatomic cation channel activity 4/755 136/18639 0.0294117647058824 0.726100506427737 0.806157974134919 0.94745656493561 GO:0031491 nucleosome binding 2/755 74/18639 0.027027027027027 0.667227492393055 0.807196414247597 0.94745656493561 GO:0004532 RNA exonuclease activity 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.94745656493561 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.94745656493561 GO:0050997 quaternary ammonium group binding 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.94745656493561 GO:0071855 neuropeptide receptor binding 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.94745656493561 GO:0071949 FAD binding 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.94745656493561 GO:0001530 lipopolysaccharide binding 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.952937809942706 GO:0140318 protein transporter activity 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.952937809942706 GO:0140828 metal cation:monoatomic cation antiporter activity 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.952937809942706 GO:0003713 transcription coactivator activity 8/755 256/18639 0.03125 0.77148178807947 0.818673774338954 0.95364010044791 GO:0030295 protein kinase activator activity 4/755 139/18639 0.0287769784172662 0.710429272476059 0.819454436475111 0.95364010044791 GO:0042056 chemoattractant activity 1/755 42/18639 0.0238095238095238 0.587795648060549 0.824240825102901 0.956818214676809 GO:0048487 beta-tubulin binding 1/755 42/18639 0.0238095238095238 0.587795648060549 0.824240825102901 0.956818214676809 GO:0005245 voltage-gated calcium channel activity 1/755 43/18639 0.0232558139534884 0.574125981826582 0.831376286577725 0.96270065025356 GO:0048156 tau protein binding 1/755 43/18639 0.0232558139534884 0.574125981826582 0.831376286577725 0.96270065025356 GO:0015370 solute:sodium symporter activity 2/755 79/18639 0.0253164556962025 0.624997904266913 0.835281086005208 0.966020734249502 GO:0019903 protein phosphatase binding 4/755 144/18639 0.0277777777777778 0.685761589403973 0.839939446195435 0.97020300795031 GO:0043021 ribonucleoprotein complex binding 5/755 177/18639 0.0282485875706215 0.697384667190481 0.848706807154873 0.979115288055993 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/755 46/18639 0.0217391304347826 0.536682983011805 0.851093158771214 0.97944095280099 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/755 46/18639 0.0217391304347826 0.536682983011805 0.851093158771214 0.97944095280099 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 8/755 268/18639 0.0298507462686567 0.736937827419195 0.854506568432412 0.981386112531152 GO:0019209 kinase activator activity 4/755 148/18639 0.027027027027027 0.667227492393055 0.854891661936374 0.981386112531152 GO:0016755 aminoacyltransferase activity 16/755 496/18639 0.032258064516129 0.796368297372356 0.856852990258491 0.981546281671813 GO:0140938 histone H3 methyltransferase activity 1/755 47/18639 0.0212765957446809 0.525264196139214 0.857139771212872 0.981546281671813 GO:0015631 tubulin binding 12/755 385/18639 0.0311688311688312 0.769477939279264 0.859570369279427 0.983120410072662 GO:0008188 neuropeptide receptor activity 1/755 48/18639 0.0208333333333333 0.51432119205298 0.862941162818631 0.98367193092253 GO:0032266 phosphatidylinositol-3-phosphate binding 1/755 48/18639 0.0208333333333333 0.51432119205298 0.862941162818631 0.98367193092253 GO:0016887 ATP hydrolysis activity 13/755 417/18639 0.0311750599520384 0.769631711849064 0.867464900243429 0.98367193092253 GO:0060590 ATPase regulator activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.98367193092253 GO:0048020 CCR chemokine receptor binding 1/755 50/18639 0.02 0.493748344370861 0.873847610921219 0.98367193092253 GO:0004842 ubiquitin-protein transferase activity 14/755 449/18639 0.0311804008908686 0.769763565834304 0.874850212743546 0.98367193092253 GO:0008017 microtubule binding 8/755 276/18639 0.0289855072463768 0.715577310682407 0.875075304194179 0.98367193092253 GO:0019787 ubiquitin-like protein transferase activity 15/755 479/18639 0.0313152400835073 0.773092397240388 0.878135343220092 0.98367193092253 GO:0003743 translation initiation factor activity 1/755 51/18639 0.0196078431372549 0.484067004285158 0.87897134290005 0.98367193092253 GO:0005272 sodium channel activity 1/755 51/18639 0.0196078431372549 0.484067004285158 0.87897134290005 0.98367193092253 GO:0030544 Hsp70 protein binding 1/755 51/18639 0.0196078431372549 0.484067004285158 0.87897134290005 0.98367193092253 GO:0030159 signaling receptor complex adaptor activity 1/755 52/18639 0.0192307692307692 0.47475802343352 0.883887236816042 0.98367193092253 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 15/755 484/18639 0.0309917355371901 0.765105905533359 0.887054337938232 0.98367193092253 GO:0005246 calcium channel regulator activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.98367193092253 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.98367193092253 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.98367193092253 GO:0052689 carboxylic ester hydrolase activity 2/755 92/18639 0.0217391304347826 0.536682983011805 0.891789687901582 0.98367193092253 GO:0017069 snRNA binding 1/755 54/18639 0.0185185185185185 0.457174392935982 0.893128849679609 0.98367193092253 GO:0098632 cell-cell adhesion mediator activity 1/755 55/18639 0.0181818181818182 0.448862131246237 0.897470400311404 0.98367193092253 GO:0001216 DNA-binding transcription activator activity 15/755 491/18639 0.0305498981670061 0.754198082032883 0.898654263599521 0.98367193092253 GO:0035591 signaling adaptor activity 3/755 129/18639 0.0232558139534884 0.574125981826582 0.89872347582196 0.98367193092253 GO:0030170 pyridoxal phosphate binding 1/755 56/18639 0.0178571428571429 0.440846736045412 0.901635803226002 0.98367193092253 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/755 56/18639 0.0178571428571429 0.440846736045412 0.901635803226002 0.98367193092253 GO:0015081 sodium ion transmembrane transporter activity 4/755 164/18639 0.024390243902439 0.602132127281538 0.903356224415564 0.98367193092253 GO:0070279 vitamin B6 binding 1/755 57/18639 0.0175438596491228 0.433112582781457 0.90563219608853 0.98367193092253 GO:0030594 neurotransmitter receptor activity 2/755 97/18639 0.0206185567010309 0.509018911722537 0.908270920328374 0.98367193092253 GO:0008408 3'-5' exonuclease activity 1/755 58/18639 0.0172413793103448 0.425645124457639 0.909466427708009 0.98367193092253 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1/755 58/18639 0.0172413793103448 0.425645124457639 0.909466427708009 0.98367193092253 GO:0016874 ligase activity 4/755 167/18639 0.0239520958083832 0.591315382480073 0.910657550144597 0.98367193092253 GO:0061630 ubiquitin protein ligase activity 10/755 353/18639 0.028328611898017 0.699360261148528 0.91069986902545 0.98367193092253 GO:0008170 N-methyltransferase activity 2/755 98/18639 0.0204081632653061 0.503824841194756 0.911272081686807 0.98367193092253 GO:0031593 polyubiquitin modification-dependent protein binding 1/755 59/18639 0.0169491525423729 0.418430800314289 0.913145069712231 0.98367193092253 GO:0001098 basal transcription machinery binding 1/755 60/18639 0.0166666666666667 0.411456953642384 0.916674427751374 0.98367193092253 GO:0001099 basal RNA polymerase II transcription machinery binding 1/755 60/18639 0.0166666666666667 0.411456953642384 0.916674427751374 0.98367193092253 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/755 60/18639 0.0166666666666667 0.411456953642384 0.916674427751374 0.98367193092253 GO:0140101 catalytic activity, acting on a tRNA 3/755 139/18639 0.0215827338129496 0.532821954357044 0.924303540284289 0.98367193092253 GO:0022824 transmitter-gated monoatomic ion channel activity 1/755 63/18639 0.0158730158730159 0.391863765373699 0.926426087673298 0.98367193092253 GO:0022835 transmitter-gated channel activity 1/755 63/18639 0.0158730158730159 0.391863765373699 0.926426087673298 0.98367193092253 GO:0140097 catalytic activity, acting on DNA 9/755 336/18639 0.0267857142857143 0.661270104068117 0.93090795925133 0.98367193092253 GO:0008013 beta-catenin binding 2/755 106/18639 0.0188679245283019 0.465800324878171 0.93216812011118 0.98367193092253 GO:0019843 rRNA binding 1/755 65/18639 0.0153846153846154 0.379806418746816 0.932285356627833 0.98367193092253 GO:0160215 deacylase activity 1/755 65/18639 0.0153846153846154 0.379806418746816 0.932285356627833 0.98367193092253 GO:0004843 cysteine-type deubiquitinase activity 2/755 108/18639 0.0185185185185185 0.457174392935982 0.936612906021741 0.98367193092253 GO:0008173 RNA methyltransferase activity 1/755 67/18639 0.0149253731343284 0.368468913709598 0.937678574574767 0.98367193092253 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/755 67/18639 0.0149253731343284 0.368468913709598 0.937678574574767 0.98367193092253 GO:0042054 histone methyltransferase activity 1/755 67/18639 0.0149253731343284 0.368468913709598 0.937678574574767 0.98367193092253 GO:0061659 ubiquitin-like protein ligase activity 10/755 372/18639 0.0268817204301075 0.663640247810297 0.938078945177437 0.98367193092253 GO:0035402 histone H3T11 kinase activity 6/755 247/18639 0.0242914979757085 0.59969434538971 0.938157319102212 0.98367193092253 GO:0016741 transferase activity, transferring one-carbon groups 5/755 215/18639 0.0232558139534884 0.574125981826582 0.939209087843015 0.98367193092253 GO:0004679 AMP-activated protein kinase activity 6/755 248/18639 0.0241935483870968 0.597276223029267 0.939611954706325 0.98367193092253 GO:0003712 transcription coregulator activity 14/755 495/18639 0.0282828282828283 0.698229981938591 0.9414760110925 0.98367193092253 GO:0016279 protein-lysine N-methyltransferase activity 1/755 69/18639 0.0144927536231884 0.357788655341204 0.94264276635017 0.98367193092253 GO:0098960 postsynaptic neurotransmitter receptor activity 1/755 69/18639 0.0144927536231884 0.357788655341204 0.94264276635017 0.98367193092253 GO:0016278 lysine N-methyltransferase activity 1/755 70/18639 0.0142857142857143 0.352677388836329 0.944974737885206 0.98367193092253 GO:0000510 H3-H4 histone complex chaperone activity 3/755 151/18639 0.0198675496688742 0.490478487785623 0.947134551567565 0.98367193092253 GO:0140584 chromatin extrusion motor activity 3/755 151/18639 0.0198675496688742 0.490478487785623 0.947134551567565 0.98367193092253 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 3/755 151/18639 0.0198675496688742 0.490478487785623 0.947134551567565 0.98367193092253 GO:0140849 ATP-dependent H2AZ histone chaperone activity 3/755 151/18639 0.0198675496688742 0.490478487785623 0.947134551567565 0.98367193092253 GO:0015616 DNA translocase activity 3/755 152/18639 0.0197368421052632 0.487251655629139 0.948714970053746 0.98367193092253 GO:0140674 ATP-dependent histone chaperone activity 3/755 152/18639 0.0197368421052632 0.487251655629139 0.948714970053746 0.98367193092253 GO:0042379 chemokine receptor binding 1/755 72/18639 0.0138888888888889 0.342880794701987 0.949358449716076 0.98367193092253 GO:0140597 protein carrier chaperone 4/755 188/18639 0.0212765957446809 0.525264196139214 0.9493874109389 0.98367193092253 GO:0101005 deubiquitinase activity 2/755 115/18639 0.0173913043478261 0.429346386409444 0.950090340348694 0.98367193092253 GO:0061775 cohesin loader activity 3/755 153/18639 0.0196078431372549 0.484067004285158 0.95025131657529 0.98367193092253 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/755 73/18639 0.0136986301369863 0.338183797514288 0.951417714565775 0.98367193092253 GO:0043539 protein serine/threonine kinase activator activity 1/755 73/18639 0.0136986301369863 0.338183797514288 0.951417714565775 0.98367193092253 GO:0051536 iron-sulfur cluster binding 1/755 76/18639 0.0131578947368421 0.324834437086093 0.957107156407655 0.98367193092253 GO:0140658 ATP-dependent chromatin remodeler activity 3/755 158/18639 0.0189873417721519 0.468748428200184 0.957309563743324 0.98367193092253 GO:0003724 RNA helicase activity 1/755 77/18639 0.012987012987013 0.320615808033027 0.95885170722984 0.98367193092253 GO:0051540 metal cluster binding 1/755 77/18639 0.012987012987013 0.320615808033027 0.95885170722984 0.98367193092253 GO:0106310 protein serine kinase activity 9/755 361/18639 0.0249307479224377 0.615475775531544 0.959061076099661 0.98367193092253 GO:0003689 DNA clamp loader activity 3/755 160/18639 0.01875 0.462889072847682 0.959861065578353 0.98367193092253 GO:0008186 ATP-dependent activity, acting on RNA 1/755 79/18639 0.0126582278481013 0.312498952133456 0.962131089558672 0.98367193092253 GO:0000049 tRNA binding 1/755 80/18639 0.0125 0.308592715231788 0.963671554396129 0.98367193092253 GO:0016829 lyase activity 4/755 200/18639 0.02 0.493748344370861 0.963895145703639 0.98367193092253 GO:0140713 histone chaperone activity 3/755 164/18639 0.0182926829268293 0.451599095461153 0.964540575070547 0.98367193092253 GO:0019783 ubiquitin-like protein peptidase activity 2/755 127/18639 0.015748031496063 0.388778223914064 0.967070695692883 0.98367193092253 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 3/755 167/18639 0.0179640718562874 0.443486536860055 0.967707828844799 0.98367193092253 GO:0008168 methyltransferase activity 4/755 204/18639 0.0196078431372549 0.484067004285158 0.967801031949364 0.98367193092253 GO:0008135 translation factor activity, RNA binding 1/755 83/18639 0.0120481927710843 0.297438761669193 0.967927495095151 0.98367193092253 GO:0004527 exonuclease activity 1/755 84/18639 0.0119047619047619 0.293897824030274 0.969232449891614 0.98367193092253 GO:0180051 translation factor activity 1/755 84/18639 0.0119047619047619 0.293897824030274 0.969232449891614 0.98367193092253 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 5/755 243/18639 0.0205761316872428 0.507971547706647 0.970828062919584 0.98367193092253 GO:0004676 3-phosphoinositide-dependent protein kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0004711 ribosomal protein S6 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0035175 histone H3S10 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0035979 histone H2AXS139 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0044022 histone H3S28 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0044023 histone H4S1 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0044024 histone H2AS1 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0044025 histone H2BS14 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0072354 histone H3T3 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0072371 histone H2AS121 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0072518 Rho-dependent protein serine/threonine kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0140823 histone H2BS36 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0140855 histone H3S57 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0140995 histone H2A kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0140997 histone H4 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0140998 histone H2B kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:1990244 histone H2AT120 kinase activity 5/755 245/18639 0.0204081632653061 0.503824841194756 0.972366215458554 0.98367193092253 GO:0008094 ATP-dependent activity, acting on DNA 4/755 210/18639 0.019047619047619 0.470236518448439 0.972927657675262 0.98367193092253 GO:0004677 DNA-dependent protein kinase activity 5/755 246/18639 0.0203252032520325 0.501776772734615 0.973106767110133 0.98367193092253 GO:0140857 histone H3T45 kinase activity 5/755 246/18639 0.0203252032520325 0.501776772734615 0.973106767110133 0.98367193092253 GO:0035403 histone H3T6 kinase activity 5/755 247/18639 0.0202429149797571 0.499745287824758 0.973828863143355 0.98367193092253 GO:0016651 oxidoreductase activity, acting on NAD(P)H 1/755 88/18639 0.0113636363636364 0.280538832028898 0.973943076756852 0.98367193092253 GO:0003735 structural constituent of ribosome 3/755 175/18639 0.0171428571428571 0.423212866603595 0.974898201739836 0.98367193092253 GO:0003727 single-stranded RNA binding 1/755 89/18639 0.0112359550561798 0.277386710320708 0.975003557434367 0.98367193092253 GO:0015297 antiporter activity 2/755 135/18639 0.0148148148148148 0.365739514348786 0.975137712551639 0.98367193092253 GO:0140104 molecular carrier activity 5/755 249/18639 0.0200803212851406 0.495731269448656 0.975219325715892 0.98367193092253 GO:0004386 helicase activity 2/755 155/18639 0.0129032258064516 0.318547318948943 0.98782279202048 0.995306298020636 GO:0140098 catalytic activity, acting on RNA 8/755 387/18639 0.020671834625323 0.510334206068073 0.989701109880467 0.996120792755367 GO:0042393 histone binding 4/755 247/18639 0.0161943319838057 0.399796230259806 0.991071096543372 0.996422452356241 GO:0140030 modification-dependent protein binding 2/755 173/18639 0.0115606936416185 0.285403667266394 0.993668595857455 0.997956270488987 GO:0031072 heat shock protein binding 1/755 131/18639 0.00763358778625954 0.188453566553764 0.995643949119025 0.998862625678677 GO:0003730 mRNA 3'-UTR binding 3/755 262/18639 0.0114503816793893 0.282680349830646 0.998633846816224 0.999874669447758 GO:0045182 translation regulator activity 5/755 356/18639 0.0140449438202247 0.346733387900885 0.998959739946997 0.999874669447758 GO:0030371 translation repressor activity 3/755 329/18639 0.00911854103343465 0.225113226916806 0.999874669447758 0.999874669447758