category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	87/558	238/9376	6.1422246317882	RPS26/RPS2/RPL23A/RPL28/NFKBIA/RPS23/RPS13/RPS18/RPL9/RPS3A/RPS7/RPL7/RPL7A/RPL30/RPL13/RPS15/RPL10A/RPS3/RPS4X/RPS12/RPS19/RPL21/RPL27A/RPL24/RPL23/RPS27A/RPS11/RPL10/RPS15A/RPL14/RPL17/RPL26/RPS5/RPL18/RPL11/RPLP1/RPS8/RPL3/RPS10/RPS6/RPL37A/RPSA/RPS20/RPL5/RPS25/RPL36/RPL27/FAU/RPS16/RPL15/RPL18A/JUN/RPS9/RPL12/RPL39/UBA52/RPL19/RPS24/RPLP2/RPL29/RPS14/RPL32/RPL13A/RPL8/RPL35A/RPLP0/RPL35/RPL31/RPL36AL/RPL22L1/RPL38/C2/RPL36A/ISG15/RPS17/FOS/MX2/RPL41/MX1/OAS1/RPL4/IL6/RPL6/OAS2/RPS27L/C1R/PIK3R3	20.2130400467226
Genetic Information Processing	Translation	hsa03010	Ribosome	81/558	222/9376	6.13077593722755	RPS26/RPS2/RPL23A/RPL28/RPS23/RPS13/RPS18/RPL9/RPS3A/RPS7/RPL7/RPL7A/RPL30/RPL13/RPS15/RPL10A/RPS3/RPS4X/RPS12/RPS19/RPL21/RPL27A/RPL24/RPL23/RPS27A/RPS11/RPL10/RPS15A/RPL14/RPL17/RPL26/RPS5/RPL18/RPL11/RPLP1/RPS8/RPL3/RPS10/RPS6/RPL37A/RPSA/RPS20/RPL5/RPS25/RPL36/RPL27/FAU/RPS16/RPL15/RPL18A/RPS9/RPL12/RPL39/UBA52/RPL19/RPS24/RPLP2/RPL29/RPS14/RPL32/RPL13A/RPL8/RPL35A/RPLP0/RPL35/RPL31/RPL36AL/RPL22L1/RPL38/RPL36A/RPS17/RPL41/RPL4/RPL6/MRPL17/RPS27L/MRPL3/MRPL18/MRPL22/MRPL47/MRPS18C	19.4612966588626
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	50/558	268/9376	3.13486331781951	NDUFA4L2/MT-CO3/RPS27A/TUBA1B/MT-ND1/UBA52/SLC39A4/DUSP1/HSPA5/MT-CO1/MT-ATP6/CALM1/TUBB2A/CYCS/MT-ND2/TXN/PSMD8/UBB/XBP1/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/MT-ND4/NDUFS5/UBC/PSMA3/PSMB5/PSMA2/COX8A/UBE2L6/TUBB4B/PSMD9/NDUFA7/SOD1/TUBA1C/PSMA5/NDUFA1/NDUFS4/VDAC2/PSMC2/NDUFA11/COX4I1/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	8.91956452371809
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	45/558	275/9376	2.74956011730205	EGR1/NDUFA4L2/MT-CO3/TUBA1B/MT-ND1/HSPA5/MT-CO1/HSPA8/MT-ATP6/PRNP/TUBB2A/CYCS/MT-ND2/PSMD8/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/MT-ND4/IL6/NDUFS5/PSMA3/PSMB5/PSMA2/COX8A/TUBB4B/PSMD9/NDUFA7/SOD1/TUBA1C/PSMA5/NDUFA1/NDUFS4/VDAC2/PSMC2/NDUFA11/COX4I1/PIK3R3/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	7.40744354415519
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	32/558	174/9376	3.09018250731265	PDIA3/HSP90AA1/OSTC/HSPA5/SEC61B/PDIA6/HSPA8/HSP90B1/KRTCAP2/CRYAB/CALR/DNAJA1/P4HB/CKAP4/LMAN1/SSR2/HSPH1/SEC61G/XBP1/DNAJB11/SEC24D/PDIA4/SSR3/DNAJB1/SEC13/LMAN2/RBX1/SKP1/MAGT1/HSP90AB1/SSR4/DAD1	7.00060234149138
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	30/558	157/9376	3.2107389904801	NDUFA4L2/MT-CO3/JUN/MT-CO1/CYCS/FOS/SOCS3/XBP1/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/IL6/NDUFS5/COX8A/NDUFA7/NDUFA1/LEP/NDUFS4/BID/NDUFA11/COX4I1/PIK3R3/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	7.02688878584374
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	45/558	308/9376	2.45496439044826	NDUFA4L2/MT-CO3/TUBA1B/MT-ND1/GPX8/MT-CO1/MT-ATP6/TUBB2A/CYCS/MT-ND2/PSMD8/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/MT-ND4/POLR2A/NDUFS5/BDNF/POLR2G/PSMA3/PSMB5/PSMA2/COX8A/TUBB4B/PSMD9/NDUFA7/POLR2K/SOD1/TUBA1C/PSMA5/WIPI1/NDUFA1/NDUFS4/VDAC2/PSMC2/NDUFA11/COX4I1/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	6.53114998488859
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/558	138/9376	3.2875175315568	NDUFA4L2/MT-CO3/MT-ND1/MT-CO1/MT-ATP6/CYCS/MT-ND2/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/MT-ND4/ATP6V1G1/NDUFS5/COX8A/NDUFA7/NDUFA1/NDUFS4/NDUFA11/COX4I1/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	6.80977379448635
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	49/558	368/9376	2.23733832008727	NDUFA4L2/MT-CO3/TUBA1B/MT-ND1/GPX8/HSPA5/MT-CO1/MT-ATP6/HNRNPA1/FUS/TUBB2A/CYCS/MT-ND2/RAB1A/PSMD8/XBP1/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/SRSF7/MT-ND4/NDUFS5/SEC13/PSMA3/PSMB5/PSMA2/COX8A/TUBB4B/ALYREF/PSMD9/NDUFA7/SOD1/TUBA1C/PSMA5/WIPI1/NDUFA1/NDUFS4/BID/PSMC2/NDUFA11/COX4I1/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	6.09138254010303
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	35/558	227/9376	2.59075047763409	NFKBIA/NDUFA4L2/MT-CO3/MT-ND1/JUN/MT-CO1/MT-ATP6/MT-ND2/FOS/GSTM3/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/MT-ND4/NDUFS5/AKR1C1/COX8A/EPHX1/NDUFA7/SOD1/NDUFA1/NDUFS4/VDAC2/NDUFA11/COX4I1/PIK3R3/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A/CBR1	6.10303509770621
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	57/558	480/9376	1.99534050179211	NDUFA4L2/MT-CO3/RPS27A/TUBA1B/MT-ND1/UBA52/GPX8/HSPA5/MT-CO1/MT-ATP6/PRNP/CALM1/FUS/TUBB2A/CYCS/MT-ND2/RAB1A/PSMD8/UBB/XBP1/UQCRH/NDUFB2/HSD17B10/NDUFA13/COX7A2L/NDUFB11/MT-ND4/IL6/NDUFS5/BDNF/UBC/DKK1/PSMA3/PSMB5/PSMA2/COX8A/UBE2L6/TUBB4B/PSMD9/NDUFA7/SOD1/TUBA1C/PSMA5/WIPI1/NDUFA1/NDUFS4/BID/VDAC2/PSMC2/NDUFA11/COX4I1/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	5.63135101130462
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	49/558	388/9376	2.122011602557	APOE/NDUFA4L2/MT-CO3/TUBA1B/MT-ND1/SLC39A4/GAPDH/MT-CO1/MT-ATP6/CALM1/TUBB2A/CYCS/MT-ND2/PSMD8/XBP1/UQCRH/NDUFB2/HSD17B10/NDUFA13/COX7A2L/NDUFB11/MT-ND4/IL6/NDUFS5/DKK1/PSMA3/PSMB5/PSMA2/COX8A/TUBB4B/PSMD9/NDUFA7/TUBA1C/PSMA5/WIPI1/NDUFA1/NDUFS4/BID/VDAC2/PSMC2/NDUFA11/COX4I1/PIK3R3/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	5.67805204913701
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	31/558	205/9376	2.54092140921409	NDUFA4L2/MT-CO3/MT-ND1/GAPDH/MT-CO1/MT-ATP6/MT-ND2/CD36/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/MT-ND4/NDUFS5/MPC2/COX8A/NDUFA7/NDUFA1/NDUFS4/VDAC2/NDUFA11/COX4I1/PIK3R3/COX6B1/COX7B/COX7C/GFPT2/SDHD/NDUFB3/COX5A	5.6113423170619
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/558	205/9376	2.37699099571641	HLA-C/HLA-B/NFKBIA/B2M/PDIA3/JUN/HLA-A/HES1/CALR/TNFAIP3/CYCS/GADD45A/ISG15/PSMD8/GADD45B/CCND1/OAS1/MYC/IL6/HLA-E/OAS2/CDKN1A/CD44/BID/PSMC2/PIK3R3/RELB/NFKB2/CCND3	5.01438152411519
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/558	75/9376	3.36057347670251	SERPINE1/CDKN2A/CYCS/STEAP3/GADD45A/GADD45B/CCND1/CD82/TNFRSF10B/SIVA1/CDKN1A/BID/ZNF385A/IGF1/CCND3	5.16298689901424
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	11/558	46/9376	4.01807698301387	PSMD8/PSMB9/POMP/PSME2/PSMA3/PSMB5/PSMA2/PSMD9/PSMA5/PSMC2/PSMB8	5.16162082195362
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	29/558	224/9376	2.17537122375832	HLA-C/HLA-B/NFKBIA/EGR1/B2M/JUN/HLA-A/CDKN2A/CALR/ZFP36/EGR2/FOS/CDKN2B/CCND1/MYC/IL6/HLA-E/MSX1/RAN/CDKN1A/VDAC2/CDKN2C/MAD1L1/PIK3R3/ETS2/RELB/NFKB2/CCND3/RANBP1	4.47876986752969
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/558	196/9376	2.14322288055007	HLA-C/HLA-B/NFKBIA/RPS27A/JUN/HLA-A/UBA52/RCAN1/CALM1/CXCL2/ZFP36/CYCS/FOS/UBB/CCND1/CLEC2B/GNG5/MYC/IL6/HLA-E/UBC/CDKN1A/TCF7/BID/PIK3R3	4.06869648161948
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/558	235/9376	1.93054221002059	NDUFA4L2/MT-CO3/RPS6/MT-ND1/MT-CO1/MT-ATP6/MT-ND2/RHEB/UQCRH/NDUFB2/NDUFA13/COX7A2L/NDUFB11/MT-ND4/NDUFS5/COX8A/NDUFA7/NDUFA1/NDUFS4/NDUFA11/COX4I1/COX6B1/COX7B/COX7C/SDHD/NDUFB3/COX5A	3.63404955255839
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/558	157/9376	2.14049266032007	HLA-C/HLA-B/ZFP36L2/ZFP36L1/SERPINE1/HLA-A/CDKN2A/CALM1/GADD45A/CDKN2B/GADD45B/CCND1/RHEB/MYC/IL6/HLA-E/CDKN1A/VDAC2/PIK3R3/CCND3	3.62508424542681
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	24/558	205/9376	1.9671649619722	HLA-C/HLA-B/NFKBIA/JUN/HLA-A/CDKN2A/EGR2/REL/CDKN2B/CCND1/PKM/GTF2H2/HLA-E/EGR3/GTF2B/GSN/GTF2A2/CDKN1A/MAD1L1/PIK3R3/YWHAQ/NFKB2/CCND3/RANBP1	3.52197954174842
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/558	248/9376	1.82934443288241	NFKBIA/RPS3/HSP90AA1/TUBA1B/JUN/GAPDH/HSP90B1/RHOB/TUBB2A/CYCS/TXN/FOS/MYC/IL6/ANXA2/TNFRSF10B/ARPC3/TUBB4B/SKP1/BRK1/AHNAK2/TUBA1C/TCF7/ELMO1/HSP90AB1/DYNLL1/ARPC2	3.32958915925706
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/558	67/9376	2.75867971968116	LDHA/ALDOA/GAPDH/TPI1/PGK1/PKM/PGM1/ALDH9A1/PGAM1/ALDH2/ENO2	3.6340452620499
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/558	142/9376	2.12994093593821	HSP90AA1/JUN/DUSP1/HSP90B1/CALM1/VCAM1/GPC1/TXN/FOS/GSTM3/KLF2/PLAT/SDC4/SUMO2/GSTP1/HSP90AB1/SDC1/PIK3R3	3.4128929811603
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/558	88/9376	2.48224177256435	CLU/SERPINE1/F10/PLAUR/C2/BDKRB1/CFI/PLAT/PROCR/F2R/F5/C1R/TFPI	3.51412310596292
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/558	180/9376	1.96033452807646	HLA-C/HLA-B/NFKBIA/B2M/PDIA3/BST2/HLA-A/CALR/CYCS/SOCS3/RHEB/OAS1/SRSF5/SRSF7/IL6/HLA-E/OAS2/ALYREF/BID/PIK3R3/SRSF9	3.27248003414013
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/558	50/9376	3.02451612903226	AOC1/OAT/ODC1/P4HA2/P4HA1/PYCR1/ALDH9A1/CKB/ALDH2	3.61057381436369
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/558	82/9376	2.45895620246525	HLA-C/HLA-B/B2M/PDIA3/HSP90AA1/HLA-A/HSPA5/HSPA8/CALR/HLA-E/PSME2/HSP90AB1	3.33784017183714
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/558	87/9376	2.31763688048449	JUN/AREG/CYCS/GADD45A/FOS/GADD45B/CCND1/EREG/MYC/CDKN1A/TCF7/PIK3R3	3.10590792927699
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/558	56/9376	2.70046082949309	NFKBIA/EEF1A1/HSPA8/CXCL2/CYCS/RAB1A/EEF1G/IL6/NFKB2	3.21048304034379
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/558	110/9376	2.1385467579016	LDHA/RPS6/SERPINE1/ALDOA/GAPDH/TIMP1/PGK1/EGLN3/IL6/RBX1/CDKN1A/PIK3R3/IGF1/ENO2	3.0214732663699
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/558	136/9376	1.97680792747206	NFKBIA/JUN/HSPA8/TNFAIP3/CYCS/FOS/MX2/CCND1/MX1/OAS1/EIF3H/IL6/OAS2/BID/PIK3R3/CCND3	2.8864253798056
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/558	31/9376	3.25216788067985	HSPA5/SEC61B/SPCS1/SEC61G/SRP19/SRP9	3.15943660080572
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/558	106/9376	2.06072901873267	NFKBIA/HSP90AA1/HSP90B1/CCND1/PLAT/GSTP1/ZEB1/CDKN1A/TCF7/HSP90AB1/PIK3R3/NKX3-1/IGF1	2.7627094049792
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/558	155/9376	1.84289513238525	HLA-C/HLA-B/TUBA1B/HLA-A/SEC61B/CALR/TUBB2A/CD36/SEC61G/ATP6V1G1/HLA-E/COLEC11/COMP/TUBB4B/TUBA1C/C1R/EEA1	2.66175497425805
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/558	87/9376	2.12450047377745	ATP1B1/MT-CO3/MT-CO1/UQCRH/COX7A2L/COX8A/COX4I1/COX6B1/COX7B/COX7C/COX5A	2.65065056216163
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/558	77/9376	2.18219056928734	NFKBIA/CDKN2A/GADD45A/RUNX1/GADD45B/CCND1/MYC/CDKN1A/PIK3R3/SHC1	2.62018779702631
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/558	201/9376	1.67192710283707	NFKBIZ/ID2/FUS/GADD45A/REL/CEBPB/RUNX1/GADD45B/NR4A3/HPGD/MLF1/MYC/PLAT/IL6/DDX5/ZEB1/PBX1/CDKN1A/CDKN2C/IGF1	2.42233855586204
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/558	37/9376	2.72478930543447	GADD45A/GADD45B/CCND1/MYC/CDKN1A/TCF7	2.64426158299997
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/558	93/9376	1.98743592708213	NFKBIA/CYCS/GADD45A/CDKN2B/GADD45B/CCND1/MYC/COL4A5/CDKN1A/CKS2/PIK3R3	2.40726506969707
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/558	94/9376	1.96629299168764	NFKBIA/FOSB/HSP90AA1/JUN/HSP90B1/CXCL2/TNFAIP3/CEBPB/FOS/IL6/HSP90AB1	2.36847968965785
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	15/558	144/9376	1.75029868578256	CYCS/PSMD8/XBP1/GTF2B/VLDLR/PSMA3/PSMB5/PSMA2/MYOD1/PSMD9/PSMA5/WIPI1/VDAC2/PSMC2/PIK3R3	2.28236565955701
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/558	119/9376	1.83560736122406	NFKBIA/JUNB/JUN/CXCL2/VCAM1/TNFAIP3/IRF1/CEBPB/FOS/SOCS3/IL6/LIF/PIK3R3	2.30758813075392
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/558	200/9376	1.59627240143369	NFKBIA/RPS3/TUBA1B/JUN/GAPDH/TUBB2A/CYCS/FOS/RAB1A/SEC24D/IL6/TNFRSF10B/CLDN1/ARPC3/TUBB4B/BRK1/F2R/TUBA1C/ARPC2	2.14412793064765
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/558	149/9376	1.69156383055495	NDUFA4L2/MT-ND1/MT-ND2/NDUFB2/NDUFA13/NDUFB11/GNG5/MT-ND4/NDUFS5/NDUFA7/NDUFA1/GABRB2/NDUFS4/NDUFA11/NDUFB3	2.14048818763337
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/558	137/9376	1.71708133846114	NFKBIA/TUBA1B/JUN/CTSC/CYCS/GADD45A/FOS/GADD45B/TNFRSF10B/ENDOG/TUBA1C/BID/PIK3R3/NOL3	2.12683554981886
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/558	75/9376	2.01634408602151	ALDOA/GAPDH/TPI1/PGK1/PKM/PYCR1/PGAM1/PHGDH/ENO2	2.22292220632323
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/558	76/9376	1.98981324278438	CDKN2A/CALM1/GADD45A/GADD45B/CCND1/CDKN1A/PIK3R3/IGF1/SHC1	2.17939661618287
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	30/558	362/9376	1.39250282183806	CSH1/RPS6/HSP90AA1/DDIT4/HSP90B1/AREG/NR4A1/FGFR4/COL9A3/CCND1/PGF/RHEB/EFNA5/EREG/GNG5/MYC/IL6/BDNF/COL4A5/COMP/COL6A3/CSH2/F2R/CDKN1A/ITGA4/HSP90AB1/PIK3R3/YWHAQ/IGF1/CCND3	1.91582564427108
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/558	156/9376	1.61566032533774	NFKBIA/CYCS/IFIT1/SOCS3/MX2/CCND1/MX1/OAS1/MYC/CLDN1/OAS2/CDKN1A/BID/PIK3R3/YWHAQ	1.95054375331317
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/558	105/9376	1.76030039255846	NFKBIA/JUN/CALM1/EGR2/IRF1/PLK3/IL6/EGR3/PIK3R3/RELB/NFKB2	1.97076238332734
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/558	70/9376	1.92032770097286	HLA-C/HLA-B/HLA-A/CYCS/CCND1/HLA-E/SGCE/BID	1.94414064723329
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	19/558	216/9376	1.47803000132749	NFKBIA/HSP90AA1/JUN/HSPA5/HSPA8/HSP90B1/CALM1/CXCL2/VCAM1/CYCS/CD36/FOS/XBP1/IL6/TNFRSF10B/VLDLR/BID/HSP90AB1/PIK3R3	1.78793605820616
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/558	148/9376	1.58946042817011	JUN/HES1/GADD45A/FOS/GADD45B/CCND1/MYC/CDKN1A/TCF7/NOTCH3/PIK3R3/IGF1/SHC1/NFKB2	1.81823247540872
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/558	59/9376	1.99356053702691	GADD45A/GADD45B/CCND1/MYC/CDKN1A/TCF7/PIK3R3	1.92575033483621
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/558	110/9376	1.68028673835125	ID3/ID1/ID2/EMP3/BMP7/BMP2/CDKN2B/MYC/RBX1/SKP1/NBL1	1.80534367967691
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/558	37/9376	2.27065775452872	UGP2/PGM1/NANS/UAP1/GFPT2	1.94803589914128
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/558	99/9376	1.69725933166793	JUN/CDKN2A/FOS/CCND1/CDKN1A/NOTCH3/CDKN2C/PIK3R3/IGF1/SHC1	1.75438879422403
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/558	38/9376	2.21090360309376	UGP2/PGM1/UAP1/HEXB/GFPT2	1.88144759158766
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/558	63/9376	1.86698526483473	GTF2H2/POLR2A/GTF2H5/POLR2G/RBX1/POLR2K/POLE4	1.73682027392537
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/558	226/9376	1.41263044374663	NFKBIA/ATP1B1/JUN/CALM1/FOS/PDE4C/HCAR2/EDNRA/HCAR3/PDE4D/ATP2B1/BDNF/PDE3B/CGA/ABCC4/PPP1R1B/F2R/PIK3R3/CRH	1.57951090958136
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/558	51/9376	1.97680792747206	KDELR2/SEC61B/SEC61G/PDIA4/KDELR3/ATP6V1G1	1.75949296116378
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/558	89/9376	1.69916636462486	CD36/COL9A3/SDC4/COL4A5/COMP/COL6A3/CD44/ITGA4/SDC1	1.66707637960372
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/558	227/9376	1.40640740214422	HLA-C/HLA-B/NFKBIA/B2M/PDIA3/HLA-A/CDKN2A/CALM1/CALR/CYCS/CCND1/RHEB/GNG5/MYC/IL6/HLA-E/CDKN1A/BID/PIK3R3	1.55921288355842
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/558	214/9376	1.41332529394031	HLA-C/HLA-B/NFKBIA/B2M/PDIA3/BST2/JUN/HLA-A/CALM1/CALR/CYCS/FOS/GNG5/HLA-E/RBX1/SKP1/BID/PIK3R3	1.5385847256415
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/558	52/9376	1.93879239040529	APOE/ANGPTL4/CD36/APOC1/VDAC2/NPC2	1.70760646543485
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/558	160/9376	1.47025089605735	VCAN/HLA-C/HLA-B/HLA-A/VCAM1/CDH15/SDC4/HLA-E/CLDN1/NRXN2/CADM1/ITGA4/SDC1/ALCAM	1.50916276152398
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/558	20/9376	2.52043010752688	UGP2/NANS/UAP1	1.71219822540655
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/558	56/9376	1.80030721966206	OSTC/KRTCAP2/MAGT1/DPM1/DAD1/DPM2	1.51098614635873
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/558	44/9376	1.90941674812643	OSTC/KRTCAP2/MAGT1/HEXB/DAD1	1.52096637057342
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/558	44/9376	1.90941674812643	TAF9/GTF2H2/GTF2H5/GTF2B/GTF2A2	1.52096637057342
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/558	45/9376	1.86698526483473	HLA-C/HLA-B/HLA-A/IL6/HLA-E	1.46646455007983
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/558	71/9376	1.65662072795194	IRF1/FOS/SOCS3/CCND1/CGA/PIK3R3/SHC1	1.39702206098314
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/558	155/9376	1.4092727482946	CDKN2A/NR4A1/RASD1/CDKN2B/CCND1/KCNK3/PBX1/CDKN1A/TCF7/HSD3B2/CDKN2C/CRH/MRAP	1.29243097005276
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	25/558	333/9376	1.26147653029373	HLA-C/HLA-B/HLA-A/HES1/ISG15/IRF1/MX2/COL9A3/CCND1/MX1/RHEB/PKM/ATP6V1G1/HES4/HLA-E/COL4A5/COMP/COL6A3/LFNG/CDKN1A/TCF7/ITGA4/NOTCH3/PIK3R3/CCND3	1.22212676427507
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/558	22/9376	2.29130009775171	AOC1/ALDH9A1/ALDH2	1.52530794337767
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/558	128/9376	1.44399641577061	PDE4C/ENTPD2/PDE4D/NME1/PDE7B/PGM1/PDE3B/DGUOK/GUCY1A2/ADSL/HPRT1	1.27226690131323
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/558	73/9376	1.61123385869298	CDKN2A/GADD45A/GADD45B/CCND1/CDKN1A/PIK3R3/IGF1	1.31878808144835
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/558	47/9376	1.7875390833524	LDHA/PKM/ALDH9A1/ALDH2/MDH1	1.36151110720842
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/558	158/9376	1.38251440497255	CDKN2A/GADD45A/CDKN2B/GADD45B/CCND1/MYC/RBX1/SKP1/CDKN1A/CDKN2C/MAD1L1/YWHAQ/CCND3	1.2197636215668
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/558	144/9376	1.40023894862605	ID3/KLF4/ID1/ID2/FGFR4/DUSP9/MYC/DLX5/LIF/TCF7/PIK3R3/IGF1	1.21750397444522
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/558	173/9376	1.35976961485073	NFKBIA/CYCS/SOCS3/MX2/MX1/OAS1/IL6/TNFRSF10B/DNAJB1/OAS2/KPNA2/BID/PIK3R3/CCND3	1.2014356435505
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/558	116/9376	1.44852305030281	ALDOA/GAPDH/TPI1/PGK1/PKM/PGAM1/PHGDH/MDH1/SDHD/ENO2	1.22271702330758
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/558	233/9376	1.29807559185934	VCAN/ATP1B1/NEBL/TNNT3/ELN/NID2/COL9A3/COL27A1/SDC4/COL4A5/BGN/SGCE/COMP/COL6A3/ITGA4/SDC1/ANK3/ENO2	1.15898470861134
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/558	204/9376	1.31787195164804	CD63/RPS6/PLAUR/GPC1/LUM/CCND1/MYC/SDC4/DDX5/CDKN1A/CD44/SDC1/ANK3/PIK3R3/IGF1/HSPB2	1.15465691148842
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/558	75/9376	1.56826762246117	CDKN2A/CYCS/GSTM3/GSTP1/CDKN1A/BID/PIK3R3	1.24290064209289
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/558	103/9376	1.46821171312246	ATP1B1/ELN/COL9A3/COL27A1/COL14A1/COL4A5/COL6A3/COL16A1/PRCP	1.20190030948824
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/558	133/9376	1.38971083623036	GADD45A/KLF2/CDKN2B/GADD45B/CCND1/PLK3/IL6/PLK2/CDKN1A/PIK3R3/IGF1	1.13862185696477
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/558	105/9376	1.44024577572965	NFKBIA/CXCL2/VCAM1/TNFAIP3/GADD45A/TNFSF13B/GADD45B/RELB/NFKB2	1.14115397376971
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/558	50/9376	1.68028673835125	VCAM1/CD36/IL6/COMP/SDC1	1.21324075838508
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/558	78/9376	1.50794963698189	JUN/CALM1/C2/IRF1/FOS/IL6/C1R	1.13315905910587
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	9/558	108/9376	1.40023894862605	EEF1A1/EIF4A3/SUMO2/SEC13/RAN/SAP18/ALYREF/KPNA2/MAGOHB	1.05233957880797
Genetic Information Processing	Transcription	hsa03040	Spliceosome	18/558	243/9376	1.24465684322315	HSPA8/HNRNPA1/EIF4A3/FUS/SF3B6/SRSF5/SRSF7/RBM25/SNRPE/DDX5/BCAS2/ALYREF/SNRPA1/SNRPD1/TCERG1/MAGOHB/SRSF9/HNRNPC	0.972011641073434
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/558	109/9376	1.38739271973957	NFKBIA/HSP90AA1/JUN/RUNX1/FOS/EBI3/IL6/HSP90AB1/IL1RAP	1.0233231821594
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/558	39/9376	1.72337101369359	HLA-C/HLA-B/HLA-A/HLA-E	1.13869500775758
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/558	139/9376	1.3297233181197	HSP90AA1/JUN/HSPA8/HSP90B1/CALM1/KRT19/FOS/KRT10/HSP90AB1/PIK3R3/SHC1	0.985165694470193
NA	NA	hsa04518	Integrin signaling	12/558	154/9376	1.30931434157241	VCAM1/COL9A3/CCND1/PGF/LIMS1/COL4A5/COMP/COL6A3/ITGA4/PIK3R3/IGF1/CCND3	0.973566336663664
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/558	54/9376	1.55582105402894	HLA-C/HLA-B/HLA-A/HLA-E/CGA	1.0303742921419
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/558	157/9376	1.28429559619204	SERPINE1/ID1/ID2/AREG/BMP7/BMP2/SNAI2/CCND1/MYC/TCF7/YWHAQ/CCND3	0.903640613093261
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/558	41/9376	1.63930413497683	CDKN2A/CCND1/MYC/CDKN1A	1.03195312628415
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/558	70/9376	1.44024577572965	SULT1A1/HSD11B1/GSTM3/GSTP1/EPHX1/CBR1	0.929994507895395
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/558	42/9376	1.60027308414405	FTH1/PRNP/STEAP3/VDAC2	0.98074772109222
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/558	71/9376	1.41996062395881	LDHA/SLC16A3/PKM/MYC/PGAM1/PIK3R3	0.893505537427443
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	21/558	300/9376	1.17620071684588	JUN/DUSP1/HSPA8/AREG/NR4A1/GADD45A/FGFR4/FOS/GADD45B/PGF/MAP3K13/EFNA5/EREG/DUSP9/MYC/DUSP5/BDNF/IL1RAP/RELB/IGF1/NFKB2	0.780258925125567
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/558	86/9376	1.36767525214637	JUN/AREG/EREG/MYC/CDKN1A/PIK3R3/SHC1	0.861635250158901
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/558	101/9376	1.33092018879307	EGR1/SERPINE1/JUN/VCAM1/CCND1/IL6/COL4A5/PIK3R3	0.841094284069492
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/558	163/9376	1.23702091166964	NFKBIA/JUN/CYCS/EGR2/FOS/MYC/IL6/EGR3/CDKN1A/BID/PIK3R3/YWHAQ	0.76788754115323
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/558	44/9376	1.52753339850114	HLA-C/HLA-B/HLA-A/HLA-E	0.882280384793394
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/558	73/9376	1.38105759316541	BST2/SERINC5/MX2/MX1/RAN/FEZ1	0.822163571380883
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/558	73/9376	1.38105759316541	CDKN2A/GADD45A/GADD45B/CCND1/CDKN1A/PIK3R3	0.822163571380883
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/558	59/9376	1.42397181216208	GPX8/PRDX6/GSTM3/ODC1/GSTP1	0.821755523498739
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/558	120/9376	1.26021505376344	NFKBIA/JUN/CALM1/IRAK3/MAGED1/BDNF/ARHGDIG/PIK3R3/SHC1	0.72165405769293
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/558	105/9376	1.28021846731524	RPS27A/JUN/UBA52/UBB/CCZ1/UBC/TOMM7/MTX2	0.726349768990893
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/558	75/9376	1.344229390681	ATP1B1/GPX8/HSPA5/HSP90B1/PDIA4/CGA	0.752889859977721
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/558	18/9376	1.86698526483473	NEU1/HEXB	0.926134662505442
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/558	32/9376	1.5752688172043	UGP2/PGM1/GAA	0.819968366641506
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/558	168/9376	1.20020481310804	CSH1/SOCS3/CNTFR/CCND1/MYC/IL6/CSH2/LIF/CDKN1A/LEP/PIK3R3/CCND3	0.658664398619688
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/558	47/9376	1.43003126668192	SOCS3/PKM/MAFA/PIK3R3	0.743445447230395
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/558	77/9376	1.30931434157241	CDKN2A/GADD45A/GADD45B/CCND1/CDKN1A/PIK3R3	0.685559235785322
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/558	62/9376	1.35506995028327	HSPA8/CRYAB/SOD1/PIK3R3/IGF1	0.705601243851313
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/558	19/9376	1.768722882475	HYAL2/HEXB	0.843715417150264
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/558	78/9376	1.2925282602702	NFKBIA/EEF1A1/JUN/FOS/MARCKSL1/ITGA4	0.652586445654783
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/558	63/9376	1.33356090345338	GADD45A/BMP2/GADD45B/CDKN1A/TCF7	0.668218207626775
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	13/558	187/9376	1.1681137753244	NFKBIA/HSP90AA1/JUN/CXCL2/TNFAIP3/TXN/OAS1/IL6/GBP3/OAS2/NLRP1/HSP90AB1/VDAC2	0.58412752200301
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/558	140/9376	1.20020481310804	EGR1/RPS6/SERPINE1/CALM1/KLF2/CCND1/GNG5/PLAT/PDE3B/NOTCH3	0.600363471604458
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/558	203/9376	1.15881844024224	JUN/COL9A3/CCND1/PGF/COL4A5/COMP/COL6A3/EMP2/ITGA4/EMP1/PIK3R3/IGF1/SHC1/CCND3	0.57545443184881
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/558	34/9376	1.48260594560405	POLR2A/POLR2G/POLR2K	0.709136575027295
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/558	34/9376	1.48260594560405	BHLHE40/RBX1/SKP1	0.709136575027295
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/558	79/9376	1.27616714305159	HSD11B1/GSTM3/GSTP1/AKR1C1/EPHX1/CBR1	0.620057304167222
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/558	49/9376	1.37166264355204	FOSB/JUN/BDNF/PPP1R1B	0.656135678136982
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/558	142/9376	1.18330051996567	RPS27A/UBA52/SOCS3/UBB/UBC/UBE2S/UBE2L6/RBX1/SKP1/UBA6	0.553644034070189
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/558	80/9376	1.26021505376344	RPS6/IL6/GAS6/PIK3R3/IGF1/SHC1	0.587959001679956
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/558	65/9376	1.2925282602702	NR4A1/KCNK3/PBX1/HSD3B2/MRAP	0.595311173176522
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/558	21/9376	1.60027308414405	CHSY1/B4GALT7	0.692714553808571
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/558	36/9376	1.40023894862605	UGP2/PGM1/GAA	0.605222202575441
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/558	37/9376	1.36239465271723	MIF/PNMT/FAH	0.555584531423919
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/558	68/9376	1.23550495467004	RUNX1/CCND1/MYC/TCF7/PIK3R3	0.490279808657861
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/558	69/9376	1.21759908576178	FOSB/JUN/CALM1/FOS/PPP1R1B	0.456346207019136
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/558	38/9376	1.32654216185625	ATP1B1/PIK3R3/IGF1	0.507366533889741
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/558	23/9376	1.46111890291413	ATP6AP2/PRCP	0.556953666268526
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/558	23/9376	1.46111890291413	ATP1B1/MDH1	0.556953666268526
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/558	54/9376	1.24465684322315	LDHA/CISD1/PHGDH/MDH1	0.453541872562102
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/558	70/9376	1.20020481310804	JUN/EGLN3/RBX1/CDKN1A/PIK3R3	0.422921438226448
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/558	103/9376	1.14194244353969	NFKBIA/SERPINE1/JUN/CALR/FOS/IL6/PIK3R3	0.364366507796545
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	16/558	250/9376	1.0753835125448	CD63/LAPTM4A/CTSC/NCOA7/NEU1/ROGDI/ATP6V1G1/ASAH1/HYAL2/OSBPL1A/GAA/SLC17A5/SLC2A6/HEXB/NPC2/ABCA5	0.303895194316585
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/558	170/9376	1.08724436010964	CDKN2A/GADD45A/GSTM3/GADD45B/CCND1/MYC/GSTP1/CDKN1A/TCF7/PIK3R3/SHC1	0.288764650555537
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	9/558	138/9376	1.0958391771856	NFKBIA/JUN/FOS/IL6/ARPC3/ELMO1/ITGA4/PIK3R3/ARPC2	0.285306279965196
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/558	122/9376	1.10182736941066	CSH1/JUNB/FOS/SOCS3/CSH2/PIK3R3/IGF1/SHC1	0.284772063757428
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/558	91/9376	1.10788136594588	PDE4C/GNG5/PDE4D/PDE7B/PDE3B/GABRB2	0.260132053439432
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/558	42/9376	1.20020481310804	AOC1/ALDH9A1/ALDH2	0.327101813147903
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/558	26/9376	1.2925282602702	HES1/MAFA	0.375721793957309
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/558	59/9376	1.13917744972966	PDE3B/CGA/PIK3R3/ABHD5	0.269758117830006
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/558	142/9376	1.0649704679691	NFKBIA/FOSB/JUNB/JUN/FOS/SOCS3/PIK3R3/RELB/NFKB2	0.196237915683925
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/558	109/9376	1.07908322646411	NFKBIA/CD36/SOCS3/PPP1R3C/IL6/PIK3R3/GFPT2	0.208903510151376
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/558	178/9376	1.03837944504853	JUN/CCND1/NOTUM/MYC/DKK1/RBX1/SKP1/TCF7/RSPO3/CCND3/APCDD1	0.130040814104218
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/558	61/9376	1.10182736941066	FTH1/ATP1B1/SLC39A4/ATP2B1	0.200703849687826
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/558	78/9376	1.0771068835585	ARPC3/ELMO1/PIK3R3/ARPC2/SHC1	0.172013832203696
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/558	95/9376	1.061233729485	JUN/CXCL2/FOS/TNFSF13B/ATP6V1G1/IL6	0.150894294194777
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/558	28/9376	1.20020481310804	ALPL/CBR1	0.266877443256395
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/558	45/9376	1.12019115890084	DEFB1/ABCC4/ABCA5	0.203297657884287
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/558	63/9376	1.0668487227627	PLOD1/SMYD3/ALDH9A1/ALDH2	0.133917174477479
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/558	115/9376	1.02278323203989	EGR1/NACA/MAFB/FOS/PDE4C/PDE4D/CDKN1A	0.0618376535576048
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/558	217/9376	1.006623391639	KLF4/HSP90AA1/JUN/HSP90B1/FOS/GSTM3/CCND1/MYC/EPHX1/KPNA2/HSP90AB1/PIK3R3/CCND3	0.0248315576627291
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/558	98/9376	1.02874698266403	ATP1B1/CALM1/NR4A1/KCNK3/ATP2B1/HSD3B2	0.0719607715713122
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/558	150/9376	1.00817204301075	GADD45A/CDKN2B/GADD45B/CCND1/MYC/CDKN1A/TCF7/PIK3R3/SHC1	0.0253797440815817
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/558	133/9376	1.01069878998572	HLA-C/HLA-B/HLA-A/HLA-E/TNFRSF10B/BID/PIK3R3/SHC1	0.031258756463247
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/558	30/9376	1.12019115890084	MDH1/SDHD	0.165858583559518
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/558	30/9376	1.12019115890084	IL6/ABCC4	0.165858583559518
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/558	99/9376	1.01835559900076	CALM1/BDKRB1/PIK3R3/IL1RAP/IGF1/ASIC4	0.0461849067278459
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/558	99/9376	1.01835559900076	KRT19/C2/DEFB1/CFI/KRT10/C1R	0.0461849067278459
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/558	82/9376	1.02456508436052	GSTM3/CES1/NME1/GSTP1/HPRT1	0.0562006763908103
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/558	253/9376	0.996217433805092	NFKBIA/RPS27A/JUN/UBA52/CYCS/UBB/UBC/ARPC3/RBX1/SKP1/CD44/ELMO1/WIPI1/PIK3R3/ARPC2	-0.0153424829912286
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/558	48/9376	1.05017921146953	HSD17B10/ALDH9A1/ALDH2	0.0876734048169511
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/558	31/9376	1.08405596022662	ALDOA/PGM1	0.117917265197688
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/558	31/9376	1.08405596022662	ALDH9A1/ALDH2	0.117917265197688
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/558	31/9376	1.08405596022662	ALDH9A1/ALDH2	0.117917265197688
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/558	32/9376	1.05017921146953	CYCS/BID	0.0715237204547109
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/558	85/9376	0.988403963736032	ENTPD2/NME1/DGUOK/ADSL/HPRT1	-0.0270150321104943
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/558	14/9376	1.20020481310804	CHST2	0.188569697322884
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/558	50/9376	1.00817204301075	TNFSF13B/IL6/ITGA4	0.0145742303957744
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/558	138/9376	0.974079268609423	RPS6/CALM1/SOCS3/PPP1R3C/RHEB/PDE3B/PIK3R3/SHC1	-0.0771641375082021
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/558	69/9376	0.974079268609423	CALM1/EDNRA/PDE3B/GUCY1A2	-0.05436064867571
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/558	122/9376	0.964098948234326	ATP1B1/RCAN1/CCND1/RHEB/MYC/NOTCH3/PIK3R3	-0.100401460447656
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/558	157/9376	0.963221697144031	CALR/BSG/CD36/CEBPB/ODC1/DUSP5/PBX1/GAS6/ELMO1	-0.116900749031819
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/558	15/9376	1.12019115890084	HEXB	0.117185727377839
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/558	15/9376	1.12019115890084	ALPL	0.117185727377839
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/558	52/9376	0.969396195202647	CGA/HSD3B2/IGF1	-0.0556664662740877
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/558	70/9376	0.960163850486431	NFKBIA/CD36/SOCS3/LEP	-0.0841516314425001
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	17/558	298/9376	0.958552837314474	CSH1/CXCL2/BMP7/TNFSF15/BMP2/CNTFR/TNFSF13B/EBI3/GDF15/IL6/RELT/TNFRSF10B/CSH2/ACKR3/LIF/LEP/IL1RAP	-0.182904983679898
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/558	71/9376	0.946640415972538	NFKBIA/JUN/CXCL2/ATP6V1G1	-0.113527509683953
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/558	89/9376	0.94398131368048	TUBA1B/TUBB2A/TUBB4B/TUBA1C/GUCY1A2	-0.13356968170202
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/558	35/9376	0.960163850486431	ALDOA/TPI1	-0.0593926058362562
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/558	16/9376	1.05017921146953	MIF	0.050531662843704
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/558	16/9376	1.05017921146953	HEXB	0.050531662843704
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/558	144/9376	0.933492632417364	NFKBIA/CXCL2/C2/CCND1/IL6/ALDH9A1/TCF7/ALDH2	-0.202311605703832
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/558	91/9376	0.923234471621568	NFKBIA/JUN/IFITM1/FOS/PIK3R3	-0.185103093155696
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/558	36/9376	0.933492632417364	DCXR/UGP2	-0.100569261522486
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/558	36/9376	0.933492632417364	POLE4/SSBP1	-0.100569261522486
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/558	55/9376	0.916520039100684	NEU1/ASAH1/HEXB	-0.156188846727299
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/558	110/9376	0.916520039100684	HSP90AA1/PDE3B/HSP90AB1/MAD1L1/PIK3R3/IGF1	-0.221538964811393
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/558	37/9376	0.908263101811489	ADSL/GFPT2	-0.140641152434764
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/558	37/9376	0.908263101811489	VCAM1/IL6	-0.140641152434764
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/558	130/9376	0.904769782189137	NFKBIA/JUN/FOS/GNG5/COL4A5/PIK3R3/SHC1	-0.275034515862141
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/558	184/9376	0.913199314321334	SEMA4A/BMP7/UNC5B/ROBO2/EPHA3/EFNA5/ROBO1/PIK3R3/SEMA3G/ENAH	-0.299119516377571
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/558	18/9376	0.933492632417364	PRDX1	-0.0710447811843862
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/558	76/9376	0.884361441237502	ANGPTL4/CD36/UBC/DBI	-0.254615994991442
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/558	169/9376	0.894827257110136	RPS27A/UBA52/DDIT4/RAB1A/UBB/RHEB/UBC/WIPI1/PIK3R3	-0.347060486763482
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	9/558	170/9376	0.889563567362429	TUBA1B/JUN/RUNX1/CCND1/CLDN1/ARPC3/TUBA1C/RAB13/ARPC2	-0.365526640795046
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/558	78/9376	0.861685506846797	BTG2/BTG1/TOB1/ENO2	-0.308558781247391
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/558	97/9376	0.866127184717141	CALM1/FOS/RASD1/GNG5/GUCY1A2	-0.333384471077055
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/558	98/9376	0.857289152220028	ARPC3/GSN/MARCKSL1/PIK3R3/ARPC2	-0.357240369810764
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/558	60/9376	0.840143369175627	GUCY1A2/CRH/IGF1	-0.312470650212807
NA	NA	hsa04517	IgSF CAM signaling	16/558	299/9376	0.899150094101006	TUBA1B/LMO7/UNC5B/TUBB2A/ROBO2/ROBO1/ARPC3/TUBB4B/CADM1/TUBA1C/ITGA4/DYNLL1/ANK3/PIK3R3/IL1RAP/ARPC2	-0.445818015343583
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/558	41/9376	0.819652067488417	PGAM1/PHGDH	-0.291114357927553
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/558	100/9376	0.840143369175627	CD36/CD7/IL6/CD44/ITGA4	-0.404266706052004
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/558	62/9376	0.813041970169962	HES1/LFNG/NOTCH3	-0.371526281767363
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/558	212/9376	0.871846892540745	ID1/CALM1/FGFR4/PGF/EFNA5/P2RY1/F2R/RAP1GAP/PIK3R3/ENAH/IGF1	-0.474757923944199
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/558	21/9376	0.800136542072026	ALDH2	-0.230642235572885
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/558	63/9376	0.800136542072026	PTGDS/HPGD/CBR1	-0.400383858671816
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/558	232/9376	0.869113830181683	BDKRB1/FGFR4/TMSB4X/SPATA13/ARPC3/GSN/BRK1/F2R/ITGA4/PIK3R3/ARPC2/ENAH	-0.507793728836678
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/558	43/9376	0.781528715512211	ALDH9A1/ALDH2	-0.361189941428988
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/558	122/9376	0.826370527057994	CD36/CCND1/RHEB/LEP/PIK3R3/IGF1	-0.485574984652741
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/558	103/9376	0.81567317395692	EIF4A3/FUS/SAP18/ALYREF/MAGOHB	-0.473167293895146
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/558	103/9376	0.81567317395692	CXCL2/IL6/COL4A5/PRDX1/PIK3R3	-0.473167293895146
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/558	44/9376	0.76376669925057	POLG2/POLE4	-0.395091586766653
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/558	44/9376	0.76376669925057	ARHGDIG/DYNLL1	-0.395091586766653
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/558	65/9376	0.775516956162117	PLPP5/ALDH9A1/ALDH2	-0.45683539792679
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/558	65/9376	0.775516956162117	KISS1/CGA/PIK3R3	-0.45683539792679
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/558	23/9376	0.730559451457067	SSBP1	-0.325438624190024
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/558	66/9376	0.76376669925057	HSD11B1/AKR1C1/HSD3B2	-0.484457781257086
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/558	238/9376	0.847203397488028	CALM1/FGFR4/REL/PGF/EFNA5/RGL1/GNG5/BDNF/PIK3R3/ETS2/IGF1/SHC1	-0.600612393804281
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/558	46/9376	0.730559451457067	FTH1/BLVRB	-0.460806650547726
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/558	24/9376	0.700119474313023	B4GALT7	-0.370014996120919
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/558	107/9376	0.785180718855726	LDHA/CALM1/PKM/PDE3B/PGAM1	-0.562168357643039
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/558	109/9376	0.770773733188649	NFKBIA/JUN/FOS/IL6/PIK3R3	-0.60551616185665
NA	NA	hsa03272	Virion - Hepatitis viruses	2/558	48/9376	0.700119474313023	CD63/CLDN1	-0.523952966882256
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/558	48/9376	0.700119474313023	ATP1B1/PIK3R3	-0.523952966882256
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/558	90/9376	0.746794105933891	ATP1B1/SCT/EPHX1/ABCC4	-0.607153378998083
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/558	90/9376	0.746794105933891	NFKBIA/JUN/FOS/PIK3R3	-0.607153378998083
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/558	49/9376	0.685831321776022	LFNG/GALNT2	-0.554635453178181
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/558	72/9376	0.700119474313023	NFKBIA/ISG15/AZI2	-0.642535831241892
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/558	93/9376	0.722703973484411	NFKBIA/JUN/FOS/NOTCH3	-0.676018585397543
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/558	93/9376	0.722703973484411	EGR1/JUN/CALM1/CGA	-0.676018585397543
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/558	93/9376	0.722703973484411	ATP1B1/CALM1/ATP2B1/GUCY1A2	-0.676018585397543
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/558	154/9376	0.76376669925057	JUN/RCAN1/CALM1/FOS/CCND1/CDKN1A/GUCY1A2	-0.743543891432369
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/558	28/9376	0.600102406554019	ATP6V1G1	-0.533072335507018
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/558	116/9376	0.724261525151403	VCAM1/THY1/CLDN1/ITGA4/PIK3R3	-0.75168963323208
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/558	29/9376	0.579409220121122	FAT4	-0.57061123177171
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/558	29/9376	0.579409220121122	CALM1	-0.57061123177171
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/558	53/9376	0.63407046730236	ATP1B1/ATP2B1	-0.672009239396199
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/558	138/9376	0.730559451457067	CALM1/RBX1/SKP1/MAD1L1/YWHAQ/IGF1	-0.802104972454997
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/558	158/9376	0.744430833446758	RPS6/DDIT4/RHEB/ATP6V1G1/SEC13/PIK3R3/IGF1	-0.814960085433019
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/558	30/9376	0.560095579450418	DPM2	-0.607049010602529
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/558	99/9376	0.678903732667174	JUN/FOS/RHEB/PIK3R3	-0.807917037020244
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/558	99/9376	0.678903732667174	IL6/SGCE/ITGA4/IGF1	-0.807917037020244
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/558	31/9376	0.542027980113308	MDH1	-0.64246256870432
NA	NA	hsa04981	Folate transport and metabolism	1/558	31/9376	0.542027980113308	ABCC4	-0.64246256870432
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/558	100/9376	0.672114695340502	CXCL2/IL6/TNFRSF10B/ACKR3	-0.82919996120263
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/558	32/9376	0.525089605734767	LDHA	-0.676920925732084
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/558	32/9376	0.525089605734767	WIPI1	-0.676920925732084
Human Diseases	Immune disease	hsa05310	Asthma	1/558	32/9376	0.525089605734767	PRG2	-0.676920925732084
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/558	33/9376	0.50917779950038	BET1	-0.710486260879018
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/558	166/9376	0.708554648702336	ATP1B1/CALM1/EDNRA/ATP2B1/PDE3B/GUCY1A2/VDAC2	-0.953013498061658
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/558	125/9376	0.672114695340502	S1PR3/SPTSSA/ASAH1/BID/PIK3R3	-0.928325561859185
Organismal Systems	Immune system	hsa04611	Platelet activation	5/558	126/9376	0.666780451726688	P2RY1/F2R/GUCY1A2/PTGIR/PIK3R3	-0.947245537358361
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/558	83/9376	0.607332556030574	NFKBIA/IL6/POLR2K	-0.903865195147654
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/558	168/9376	0.700119474313023	FTH1/HSP90AA1/TNFAIP3/TNFRSF10B/BID/HSP90AB1/VDAC2	-0.986592794863421
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	11/558	250/9376	0.739326164874552	HLA-C/HLA-B/HLA-A/ARF4/HSPA8/FGFR4/ARF5/HLA-E/ARPC3/EEA1/ARPC2	-1.05086010328341
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/558	191/9376	0.703785021298955	FOSB/CALM1/GNG5/BDNF/PPP1R1B/CRH/SHC1/HAT1	-1.0404035117528
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/558	36/9376	0.466746316208682	GALNT2	-0.806360725620413
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/558	86/9376	0.586146536634158	SGCE/TCF7/ITGA4	-0.969852418281329
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/558	154/9376	0.654657170786203	UGP2/NME1/MTHFD1L/ADSL/ALPL/ALDH2	-1.08696593705158
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/558	133/9376	0.631686743741073	CALM1/FOS/GNG5/CALY/PPP1R1B	-1.07610434403828
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/558	134/9376	0.626972663563901	CALM1/PPP1R14A/EDNRA/GUCY1A2/PTGIR	-1.09402631092915
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/558	39/9376	0.430842753423399	MTHFD1L	-0.895939293996026
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/558	90/9376	0.560095579450418	RHEB/PIK3R3/IGF1	-1.05483111425178
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/558	66/9376	0.50917779950038	JUN/IL6	-1.00655848896587
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/558	68/9376	0.494201981868016	DHRS4L2/RDH10	-1.05298232853197
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/558	41/9376	0.409826033744208	SSBP1	-0.952648100033403
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/558	41/9376	0.409826033744208	GABRB2	-0.952648100033403
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/558	181/9376	0.649834650191093	CALM1/CYCS/CEBPB/PLK3/IL6/BID/EEA1	-1.19661455165236
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/558	93/9376	0.542027980113308	LMO7/SNAI2/TCF7	-1.11648767898249
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/558	43/9376	0.390764357756106	CD36	-1.00722521247786
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/558	73/9376	0.460352531055138	GSTM3/GSTP1	-1.16433446888897
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/558	122/9376	0.550913684705329	NFKBIA/JUN/FOS/PIK3R3	-1.25592203306291
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/558	76/9376	0.442180720618751	ATP1B1/CALM1	-1.22822103946117
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/558	102/9376	0.494201981868016	ATP1B1/ATP2B1/SCT	-1.29199654961416
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/558	78/9376	0.430842753423399	TPI1/PLCH2	-1.26970400814957
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/558	104/9376	0.484698097601323	PLPP5/PEMT/ETNK2	-1.32925834171097
NA	NA	hsa04081	Hormone signaling	8/558	219/9376	0.613803374740184	CSH1/GNG5/CGA/CSH2/LEP/PIK3R3/CRH/IGF1	-1.45469389152333
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/558	105/9376	0.480081925243216	SGCE/ITGA4/IGF1	-1.34767125490319
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/558	154/9376	0.545547642321836	ATP1B1/CALM1/KCNE1/ATP2B1/SCN7A	-1.43038798267078
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/558	83/9376	0.404888370687049	PRDX1/SOD1	-1.36986321943581
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/558	54/9376	0.311164210805788	HES1	-1.27695538617729
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/558	112/9376	0.450076804915515	NFKBIA/HSPA8/CYCS	-1.47275147593873
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/558	86/9376	0.390764357756106	ENTPD2/P2RY1	-1.42772433539139
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/558	56/9376	0.30005120327701	CCND1	-1.3215086769497
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/558	115/9376	0.43833567087424	FOS/GNG5/PIK3R3	-1.52445465767661
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/558	115/9376	0.43833567087424	DUSP1/GNG5/GABRB2	-1.52445465767661
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/558	89/9376	0.377592525472192	GNG5/GABRB2	-1.48405422768132
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/558	59/9376	0.284794362432416	NME1	-1.38623409917619
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/558	323/9376	0.624255134991178	CDKN2A/DDIT4/SOX4/CCND1/EFNA5/MYC/ZEB1/CDKN1A/CD44/NOTCH3/PIK3R3/SHC1	-1.7286845302056
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/558	60/9376	0.280047789725209	PIK3R3	-1.4072856040227
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/558	193/9376	0.522368934202463	NFKBIA/CXCL2/GNG5/ELMO1/PIK3R3/SHC1	-1.68653989530017
NA	NA	hsa04382	Cornified envelope formation	7/558	217/9376	0.542027980113308	S100A11/KRT19/PKP1/CLDN1/COL4A5/KRT10/ABHD5	-1.71696907559722
Cellular Processes	Cell motility	hsa04814	Motor proteins	6/558	194/9376	0.519676310830285	TUBA1B/TNNT3/TUBB2A/TUBB4B/TUBA1C/DYNLL1	-1.70052850979532
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/558	370/9376	0.635784171268042	CSH1/BDKRB1/S1PR3/KISS1/EDNRA/P2RY1/CGA/CSH2/SCT/F2R/GABRB2/LEP/PTGIR/CRH	-1.79808988247617
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/558	149/9376	0.451083688147988	RHEB/F2R/PIK3R3/SHC1	-1.69897387573849
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/558	98/9376	0.342915660888011	CALM1/PIK3R3	-1.64484379395699
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/558	67/9376	0.25078906542556	CALM1	-1.54813091695845
NA	NA	hsa04519	Cadherin signaling	15/558	404/9376	0.623868838496753	NFKBIA/KRT19/PKP1/CDH15/FAT4/KRT10/CDH13/ARPC3/BRK1/PPP1R1B/TCF7/GABRB2/YWHAQ/ARPC2/ENAH	-1.94403041633008
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/558	101/9376	0.332730047198268	CALM1/TCF7	-1.69598882824222
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/558	69/9376	0.243519817152356	PIK3R3	-1.58648121576025
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/558	254/9376	0.52922416955945	CALM1/BDKRB1/FGFR4/EDNRA/ATP2B1/F2R/VDAC2/STIM2	-1.91339076238853
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/558	79/9376	0.212694523841931	ATP6V1G1	-1.76767773931556
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/558	143/9376	0.352507707346417	C2/SNRPD1/C1R	-1.96267727769409
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/558	83/9376	0.202444185343525	SKP1	-1.83586124372397
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/558	86/9376	0.195382178878053	ATP1B1	-1.88559625250144
NA	NA	hsa04082	Neuroactive ligand signaling	4/558	199/9376	0.337746078060554	GNG5/P2RY1/SLC17A9/GABRB2	-2.37529963325543
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/558	116/9376	0.144852305030281	GNG5	-2.33121495846381
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/558	117/9376	0.143614251141133	BAZ1A	-2.34475791650038
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/558	195/9376	0.258505652054039	VDAC2/PIK3R3/HAT1	-2.6320724981352
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/558	183/9376	0.0918189474508882	RAN	-3.12095166130868
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/558	449/9376	0.0374228672238587	CALM1	-5.25803695095063