ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 82/918 175/18639 0.468571428571429 9.51383753501401 5.05740928328526e-60 4.87534254908699e-57 GO:0019843 rRNA binding 18/918 65/18639 0.276923076923077 5.62262443438914 1.37079491054852e-09 6.60723146884384e-07 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 18/918 68/18639 0.264705882352941 5.37456747404844 3.04734003913011e-09 9.79211932573808e-07 GO:0009055 electron transfer activity 23/918 116/18639 0.198275862068966 4.02577755240027 9.21527624232658e-09 2.22088157440071e-06 GO:0005201 extracellular matrix structural constituent 28/918 168/18639 0.166666666666667 3.38398692810458 1.36198105083565e-08 2.62589946601114e-06 GO:0051082 unfolded protein binding 22/918 121/18639 0.181818181818182 3.69162210338681 9.88537503488017e-08 1.37700103332025e-05 GO:0004857 enzyme inhibitor activity 47/918 416/18639 0.112980769230769 2.29395267722474 9.99897015896448e-08 1.37700103332025e-05 GO:0004129 cytochrome-c oxidase activity 8/918 15/18639 0.533333333333333 10.8287581699346 1.58692974275981e-07 1.52980027202046e-05 GO:0031386 protein tag activity 8/918 15/18639 0.533333333333333 10.8287581699346 1.58692974275981e-07 1.52980027202046e-05 GO:0141047 molecular tag activity 8/918 15/18639 0.533333333333333 10.8287581699346 1.58692974275981e-07 1.52980027202046e-05 GO:1990948 ubiquitin ligase inhibitor activity 7/918 11/18639 0.636363636363636 12.9206773618538 1.90592300677507e-07 1.67028161684652e-05 GO:0022853 active monoatomic ion transmembrane transporter activity 21/918 118/18639 0.177966101694915 3.61340977068794 2.80306708751425e-07 2.25173756743202e-05 GO:0016675 oxidoreductase activity, acting on a heme group of donors 8/918 16/18639 0.5 10.1519607843137 3.03657555774028e-07 2.25173756743202e-05 GO:0031625 ubiquitin protein ligase binding 36/918 302/18639 0.119205298013245 2.42033502142579 8.81551004255202e-07 6.07010834358582e-05 GO:0045296 cadherin binding 38/918 334/18639 0.11377245508982 2.3100270048139 1.40796639974539e-06 8.36532802562531e-05 GO:0044389 ubiquitin-like protein ligase binding 37/918 322/18639 0.114906832298137 2.33305931068079 1.52387974804796e-06 8.36532802562531e-05 GO:0003756 protein disulfide isomerase activity 8/918 19/18639 0.421052631578947 8.54901960784314 1.561990710179e-06 8.36532802562531e-05 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 8/918 19/18639 0.421052631578947 8.54901960784314 1.561990710179e-06 8.36532802562531e-05 GO:0019207 kinase regulator activity 34/918 287/18639 0.118466898954704 2.40534262485482 2.03066657629595e-06 0.000103029609449963 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/918 15/18639 0.466666666666667 9.47516339869281 3.1222718610154e-06 0.000150493503700942 GO:0019887 protein kinase regulator activity 31/918 255/18639 0.12156862745098 2.4683198769704 3.31743841595124e-06 0.000152286220617952 GO:0015399 primary active transmembrane transporter activity 23/918 166/18639 0.13855421686747 2.81319395227971 7.05125775066417e-06 0.000308973294165466 GO:0016860 intramolecular oxidoreductase activity 12/918 53/18639 0.226415094339623 4.59711431742508 7.79244008766804e-06 0.000326604880196173 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 12/918 58/18639 0.206896551724138 4.20081135902637 2.07592186501046e-05 0.000833828615779203 GO:0140416 transcription regulator inhibitor activity 9/918 33/18639 0.272727272727273 5.53743315508021 2.16827258783496e-05 0.000836085909869159 GO:0015035 protein-disulfide reductase activity 9/918 34/18639 0.264705882352941 5.37456747404844 2.82077230456052e-05 0.00104585557753705 GO:0061134 peptidase regulator activity 26/918 226/18639 0.115044247787611 2.33584938400139 5.21822298220736e-05 0.00186309887216589 GO:0043021 ribonucleoprotein complex binding 22/918 177/18639 0.124293785310734 2.52365126841697 6.0964755757192e-05 0.0020989294482119 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 6/918 16/18639 0.375 7.61397058823529 7.34359847458028e-05 0.00244111342396393 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 10/918 48/18639 0.208333333333333 4.22998366013072 9.47979632450557e-05 0.00304617455227446 GO:0015036 disulfide oxidoreductase activity 9/918 40/18639 0.225 4.56838235294118 0.000112713640877269 0.00334985807902779 GO:0048027 mRNA 5'-UTR binding 7/918 24/18639 0.291666666666667 5.92197712418301 0.000113679271128736 0.00334985807902779 GO:0043022 ribosome binding 16/918 112/18639 0.142857142857143 2.90056022408964 0.000117868761905528 0.00334985807902779 GO:0015078 proton transmembrane transporter activity 22/918 185/18639 0.118918918918919 2.4145204027557 0.000118148521459486 0.00334985807902779 GO:0008137 NADH dehydrogenase (ubiquinone) activity 9/918 41/18639 0.219512195121951 4.45695839311334 0.000138164737567523 0.00380545162900264 GO:0008135 translation factor activity, RNA binding 13/918 83/18639 0.156626506024096 3.18013229388141 0.000198340559778989 0.00531111943408183 GO:0180051 translation factor activity 13/918 84/18639 0.154761904761905 3.14227357609711 0.000224253663417059 0.00579222981039483 GO:0005507 copper ion binding 11/918 63/18639 0.174603174603175 3.54512916277622 0.000228324411613074 0.00579222981039483 GO:0003954 NADH dehydrogenase activity 9/918 44/18639 0.204545454545455 4.15307486631016 0.000244867399830646 0.00597012425991999 GO:0048029 monosaccharide binding 12/918 74/18639 0.162162162162162 3.29252782193959 0.000247722998336929 0.00597012425991999 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 5/918 13/18639 0.384615384615385 7.80920060331825 0.000264821659928508 0.00622653854075809 GO:0055106 ubiquitin-protein transferase regulator activity 8/918 36/18639 0.222222222222222 4.5119825708061 0.000296484830748681 0.00672538526219232 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 6/918 20/18639 0.3 6.09117647058823 0.000299991251321856 0.00672538526219232 GO:0140313 molecular sequestering activity 10/918 55/18639 0.181818181818182 3.69162210338681 0.000310296981936006 0.0067983247860525 GO:0019209 kinase activator activity 18/918 148/18639 0.121621621621622 2.46939586645469 0.00036192484856508 0.00775323453370527 GO:0030295 protein kinase activator activity 17/918 139/18639 0.122302158273381 2.48321342925659 0.000488648061902747 0.0102403637320489 GO:0001968 fibronectin binding 7/918 30/18639 0.233333333333333 4.73758169934641 0.000516297714395671 0.0105895956739878 GO:0030021 extracellular matrix structural constituent conferring compression resistance 6/918 22/18639 0.272727272727273 5.53743315508021 0.000530663411690954 0.0106574901847933 GO:0016853 isomerase activity 20/918 180/18639 0.111111111111111 2.25599128540305 0.000578097072735885 0.0113731750636203 GO:0030246 carbohydrate binding 27/918 280/18639 0.0964285714285714 1.9578781512605 0.000690934246142878 0.0133212122656347 GO:0061135 endopeptidase regulator activity 20/918 184/18639 0.108695652173913 2.20694799658994 0.000764621575930376 0.0144528470430761 GO:0004860 protein kinase inhibitor activity 12/918 84/18639 0.142857142857143 2.90056022408964 0.000813209504933521 0.0150756531299214 GO:0005540 hyaluronic acid binding 6/918 24/18639 0.25 5.07598039215686 0.000879815332367295 0.0160026788755108 GO:0005539 glycosaminoglycan binding 24/918 242/18639 0.0991735537190083 2.01361205639281 0.000906256525915768 0.0161198917118775 GO:0051087 protein-folding chaperone binding 16/918 134/18639 0.119402985074627 2.42434884401522 0.000919703365304212 0.0161198917118775 GO:0044183 protein folding chaperone 11/918 75/18639 0.146666666666667 2.97790849673203 0.00106176893360621 0.0179477754336312 GO:0051787 misfolded protein binding 5/918 17/18639 0.294117647058824 5.9717416378316 0.00107984540990727 0.0179477754336312 GO:0070492 oligosaccharide binding 5/918 17/18639 0.294117647058824 5.9717416378316 0.00107984540990727 0.0179477754336312 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 9/918 54/18639 0.166666666666667 3.38398692810458 0.00118267781882124 0.0193237528363334 GO:0016651 oxidoreductase activity, acting on NAD(P)H 12/918 88/18639 0.136363636363636 2.76871657754011 0.00123512289743971 0.0198443078855314 GO:0003746 translation elongation factor activity 5/918 18/18639 0.277777777777778 5.63997821350763 0.00143502316820038 0.0226780710515602 GO:0019210 kinase inhibitor activity 12/918 90/18639 0.133333333333333 2.70718954248366 0.00150596408605212 0.0234153125637782 GO:0050840 extracellular matrix binding 10/918 67/18639 0.149253731343284 3.03043605501902 0.0015449720228689 0.0236405242864384 GO:0023026 MHC class II protein complex binding 6/918 27/18639 0.222222222222222 4.5119825708061 0.00170545834774881 0.0256106237791636 GO:0030414 peptidase inhibitor activity 18/918 169/18639 0.106508875739645 2.16254785938044 0.00172685741249547 0.0256106237791636 GO:0140297 DNA-binding transcription factor binding 39/918 488/18639 0.0799180327868853 1.62264946962392 0.00208510288939662 0.0302935370382623 GO:0031543 peptidyl-proline dioxygenase activity 4/918 12/18639 0.333333333333333 6.76797385620915 0.00210546367382114 0.0302935370382623 GO:0016505 peptidase activator activity involved in apoptotic process 5/918 20/18639 0.25 5.07598039215686 0.00239238969510708 0.0339156421482828 GO:0004866 endopeptidase inhibitor activity 17/918 161/18639 0.105590062111801 2.14389233954451 0.00250797568792037 0.0350389646834092 GO:0008083 growth factor activity 17/918 162/18639 0.104938271604938 2.13065843621399 0.00267705532317895 0.0363694486273996 GO:0005518 collagen binding 10/918 72/18639 0.138888888888889 2.81998910675381 0.0026786627101093 0.0363694486273996 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 14/918 122/18639 0.114754098360656 2.32995821279331 0.0027254935854921 0.0364913307835331 GO:0042277 peptide binding 23/918 249/18639 0.0923694779116466 1.87546263485314 0.00289083232473012 0.0381748268635594 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 7/918 40/18639 0.175 3.5531862745098 0.00308148255364072 0.0401425565095899 GO:0003743 translation initiation factor activity 8/918 51/18639 0.156862745098039 3.18492887351019 0.00325198714030789 0.0417988747100908 GO:0008191 metalloendopeptidase inhibitor activity 4/918 14/18639 0.285714285714286 5.80112044817927 0.00393482251285977 0.0499101171368002 GO:0005246 calcium channel regulator activity 8/918 53/18639 0.150943396226415 3.06474287828339 0.00415212797514211 0.0519824852991817 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 29/918 349/18639 0.0830945558739255 1.68714534524411 0.00428581803746287 0.0529683152322335 GO:0030547 signaling receptor inhibitor activity 7/918 44/18639 0.159090909090909 3.23016934046346 0.00534257470857202 0.06519293695017 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 14/918 132/18639 0.106060606060606 2.15344622697564 0.00556208619815902 0.0670231386878161 GO:1990841 promoter-specific chromatin binding 9/918 68/18639 0.132352941176471 2.68728373702422 0.00594418631237118 0.0707431556188373 GO:0016504 peptidase activator activity 8/918 57/18639 0.140350877192982 2.84967320261438 0.006516112256998 0.0766040514115374 GO:0043023 ribosomal large subunit binding 4/918 16/18639 0.25 5.07598039215686 0.00661360540438186 0.0767325191404149 GO:0005537 D-mannose binding 5/918 25/18639 0.2 4.06078431372549 0.00668623610767101 0.0767325191404149 GO:0030291 protein serine/threonine kinase inhibitor activity 7/918 46/18639 0.152173913043478 3.08972719522592 0.0068551964925067 0.077745993162076 GO:0004867 serine-type endopeptidase inhibitor activity 11/918 95/18639 0.115789473684211 2.35098039215686 0.00696520539137619 0.0780750929917052 GO:0003924 GTPase activity 27/918 331/18639 0.081570996978852 1.65621112493336 0.00726064088466416 0.080451239227773 GO:0016922 nuclear receptor binding 14/918 137/18639 0.102189781021898 2.07485329898383 0.00768191913890709 0.081604138008003 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 6/918 36/18639 0.166666666666667 3.38398692810458 0.00770329518540278 0.081604138008003 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 6/918 36/18639 0.166666666666667 3.38398692810458 0.00770329518540278 0.081604138008003 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 6/918 36/18639 0.166666666666667 3.38398692810458 0.00770329518540278 0.081604138008003 GO:0050750 low-density lipoprotein particle receptor binding 5/918 26/18639 0.192307692307692 3.90460030165913 0.00794881276810153 0.0832897337874986 GO:0023023 MHC protein complex binding 6/918 37/18639 0.162162162162162 3.29252782193959 0.00881990609945326 0.0914235427943327 GO:0043539 protein serine/threonine kinase activator activity 9/918 73/18639 0.123287671232877 2.50322320709106 0.00942476289252522 0.096653951365897 GO:0098641 cadherin binding involved in cell-cell adhesion 4/918 18/18639 0.222222222222222 4.5119825708061 0.010282380107039 0.104339099191428 GO:0008201 heparin binding 16/918 172/18639 0.0930232558139535 1.88873689010488 0.011001314571774 0.109451671246094 GO:0004090 carbonyl reductase (NADPH) activity 3/918 10/18639 0.3 6.09117647058823 0.011013290571443 0.109451671246094 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 6/918 39/18639 0.153846153846154 3.1236802413273 0.0113921823539037 0.112061875399625 GO:0019208 phosphatase regulator activity 12/918 117/18639 0.102564102564103 2.0824534942182 0.0126583792790966 0.122515849898059 GO:0043236 laminin binding 5/918 29/18639 0.172413793103448 3.50067613252197 0.0127091130599646 0.122515849898059 GO:0140662 ATP-dependent protein folding chaperone 6/918 40/18639 0.15 3.04558823529412 0.0128587764363031 0.122731291926695 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/918 30/18639 0.166666666666667 3.38398692810458 0.014647629394261 0.134851001060798 GO:0016769 transferase activity, transferring nitrogenous groups 5/918 30/18639 0.166666666666667 3.38398692810458 0.014647629394261 0.134851001060798 GO:0035925 mRNA 3'-UTR AU-rich region binding 5/918 30/18639 0.166666666666667 3.38398692810458 0.014647629394261 0.134851001060798 GO:0004864 protein phosphatase inhibitor activity 7/918 53/18639 0.132075471698113 2.68165001849796 0.0146881277089043 0.134851001060798 GO:0031418 L-ascorbic acid binding 4/918 20/18639 0.2 4.06078431372549 0.0150592410509814 0.135518480029088 GO:0043024 ribosomal small subunit binding 4/918 20/18639 0.2 4.06078431372549 0.0150592410509814 0.135518480029088 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 35/918 484/18639 0.0723140495867769 1.46825879111975 0.015182568302014 0.135518480029088 GO:0016859 cis-trans isomerase activity 6/918 42/18639 0.142857142857143 2.90056022408964 0.0161789760087609 0.141535512140183 GO:0035198 miRNA binding 6/918 42/18639 0.142857142857143 2.90056022408964 0.0161789760087609 0.141535512140183 GO:0019888 protein phosphatase regulator activity 11/918 107/18639 0.102803738317757 2.08731903976544 0.0162971388460169 0.141535512140183 GO:0070325 lipoprotein particle receptor binding 5/918 31/18639 0.161290322580645 3.27482605945604 0.0167746389709986 0.143237381498963 GO:0019838 growth factor binding 13/918 136/18639 0.0955882352941176 1.94081603229527 0.0167902739723888 0.143237381498963 GO:0001216 DNA-binding transcription activator activity 35/918 491/18639 0.0712830957230143 1.44732638472904 0.0184555242109117 0.151964336254997 GO:0004859 phospholipase inhibitor activity 3/918 12/18639 0.25 5.07598039215686 0.0187590830024322 0.151964336254997 GO:0005165 neurotrophin receptor binding 3/918 12/18639 0.25 5.07598039215686 0.0187590830024322 0.151964336254997 GO:0035259 nuclear glucocorticoid receptor binding 3/918 12/18639 0.25 5.07598039215686 0.0187590830024322 0.151964336254997 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/918 12/18639 0.25 5.07598039215686 0.0187590830024322 0.151964336254997 GO:0097371 MDM2/MDM4 family protein binding 3/918 12/18639 0.25 5.07598039215686 0.0187590830024322 0.151964336254997 GO:0043425 bHLH transcription factor binding 5/918 32/18639 0.15625 3.17248774509804 0.0190969385559473 0.15341207306611 GO:0019212 phosphatase inhibitor activity 7/918 56/18639 0.125 2.53799019607843 0.0194810902365381 0.155204718909279 GO:0002039 p53 binding 8/918 69/18639 0.115942028985507 2.35407786302927 0.0197333530550508 0.155854556270881 GO:0001046 core promoter sequence-specific DNA binding 6/918 44/18639 0.136363636363636 2.76871657754011 0.0200476815120221 0.155854556270881 GO:0030020 extracellular matrix structural constituent conferring tensile strength 6/918 44/18639 0.136363636363636 2.76871657754011 0.0200476815120221 0.155854556270881 GO:0001540 amyloid-beta binding 9/918 83/18639 0.108433734939759 2.20163004961021 0.0207190977985529 0.15978568222244 GO:0005525 GTP binding 28/918 378/18639 0.0740740740740741 1.5039941902687 0.0210219754827444 0.160834796550521 GO:0140311 protein sequestering activity 5/918 33/18639 0.151515151515152 3.07635175282234 0.0216207671523177 0.164113539644364 GO:0039706 co-receptor binding 3/918 13/18639 0.230769230769231 4.68552036199095 0.0235097498658298 0.177057803677031 GO:0017134 fibroblast growth factor binding 4/918 23/18639 0.173913043478261 3.5311167945439 0.0244993969302984 0.181672451083136 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/918 23/18639 0.173913043478261 3.5311167945439 0.0244993969302984 0.181672451083136 GO:0070888 E-box binding 7/918 59/18639 0.11864406779661 2.40893984712529 0.0252716500816344 0.185968478463325 GO:0005154 epidermal growth factor receptor binding 5/918 35/18639 0.142857142857143 2.90056022408964 0.0272950469760964 0.199336555189068 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/918 24/18639 0.166666666666667 3.38398692810458 0.0282850825454096 0.203483728162499 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/918 24/18639 0.166666666666667 3.38398692810458 0.0282850825454096 0.203483728162499 GO:0044548 S100 protein binding 3/918 14/18639 0.214285714285714 4.35084033613445 0.0288483664166398 0.205998705375117 GO:0004033 aldo-keto reductase (NADPH) activity 5/918 36/18639 0.138888888888889 2.81998910675381 0.0304550069423373 0.215872255091273 GO:0003725 double-stranded RNA binding 8/918 75/18639 0.106666666666667 2.16575163398693 0.0308648278395725 0.217180248447795 GO:0019211 phosphatase activator activity 4/918 25/18639 0.16 3.24862745098039 0.0323991485335504 0.226324486857555 GO:0032813 tumor necrosis factor receptor superfamily binding 6/918 50/18639 0.12 2.43647058823529 0.0352808078370889 0.244681286006861 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/918 26/18639 0.153846153846154 3.1236802413273 0.0368446641272683 0.24837941411669 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/918 26/18639 0.153846153846154 3.1236802413273 0.0368446641272683 0.24837941411669 GO:0050681 nuclear androgen receptor binding 4/918 26/18639 0.153846153846154 3.1236802413273 0.0368446641272683 0.24837941411669 GO:0070412 R-SMAD binding 4/918 26/18639 0.153846153846154 3.1236802413273 0.0368446641272683 0.24837941411669 GO:0019001 guanyl nucleotide binding 28/918 400/18639 0.07 1.42127450980392 0.0394365089185736 0.26218479032762 GO:0032561 guanyl ribonucleotide binding 28/918 400/18639 0.07 1.42127450980392 0.0394365089185736 0.26218479032762 GO:0005521 lamin binding 3/918 16/18639 0.1875 3.80698529411765 0.0412685738372023 0.268803413372047 GO:0019841 retinol binding 3/918 16/18639 0.1875 3.80698529411765 0.0412685738372023 0.268803413372047 GO:0055102 lipase inhibitor activity 3/918 16/18639 0.1875 3.80698529411765 0.0412685738372023 0.268803413372047 GO:0048306 calcium-dependent protein binding 8/918 80/18639 0.1 2.03039215686274 0.0429380983944805 0.277800851357579 GO:0097718 disordered domain specific binding 4/918 28/18639 0.142857142857143 2.90056022408964 0.0467351722364305 0.300351373572794 GO:0005092 GDP-dissociation inhibitor activity 3/918 17/18639 0.176470588235294 3.58304498269896 0.0483297752050392 0.30253183959518 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/918 17/18639 0.176470588235294 3.58304498269896 0.0483297752050392 0.30253183959518 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/918 17/18639 0.176470588235294 3.58304498269896 0.0483297752050392 0.30253183959518 GO:0048038 quinone binding 3/918 17/18639 0.176470588235294 3.58304498269896 0.0483297752050392 0.30253183959518 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 11/918 128/18639 0.0859375 1.74486825980392 0.0512548331693126 0.318771994678821 GO:0004629 phospholipase C activity 4/918 29/18639 0.137931034482759 2.80054090601758 0.052179341704665 0.322441573098058 GO:1901681 sulfur compound binding 20/918 275/18639 0.0727272727272727 1.47664884135472 0.0533567240494225 0.327617082698365 GO:0005178 integrin binding 13/918 161/18639 0.0807453416149068 1.6394470831811 0.0549400104016832 0.335203607767232 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/918 18/18639 0.166666666666667 3.38398692810458 0.0559392542246392 0.339153717437435 GO:0048019 receptor antagonist activity 4/918 30/18639 0.133333333333333 2.70718954248366 0.057953451290881 0.349169544027558 GO:0005179 hormone activity 11/918 132/18639 0.0833333333333333 1.69199346405229 0.0613262812158103 0.367195870136902 GO:0005520 insulin-like growth factor binding 3/918 19/18639 0.157894736842105 3.20588235294118 0.0640792636205453 0.376661037379303 GO:0016918 retinal binding 3/918 19/18639 0.157894736842105 3.20588235294118 0.0640792636205453 0.376661037379303 GO:0070003 threonine-type peptidase activity 3/918 19/18639 0.157894736842105 3.20588235294118 0.0640792636205453 0.376661037379303 GO:0008081 phosphoric diester hydrolase activity 8/918 87/18639 0.0919540229885057 1.86702727067839 0.064518758788715 0.376945960438311 GO:0061980 regulatory RNA binding 6/918 58/18639 0.103448275862069 2.10040567951318 0.0649161020227546 0.376982664758648 GO:0022804 active transmembrane transporter activity 30/918 457/18639 0.0656455142231947 1.33286137211996 0.0674424552361313 0.389308543997788 GO:0042605 peptide antigen binding 5/918 45/18639 0.111111111111111 2.25599128540305 0.0690725855140025 0.394995949529406 GO:0070063 RNA polymerase binding 6/918 59/18639 0.101694915254237 2.06480558325025 0.0694041531859003 0.394995949529406 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/918 32/18639 0.125 2.53799019607843 0.0704764557251638 0.394995949529406 GO:0071813 lipoprotein particle binding 4/918 32/18639 0.125 2.53799019607843 0.0704764557251638 0.394995949529406 GO:0071814 protein-lipid complex binding 4/918 32/18639 0.125 2.53799019607843 0.0704764557251638 0.394995949529406 GO:0016247 channel regulator activity 13/918 168/18639 0.0773809523809524 1.57113678804855 0.0718647589562732 0.400448714646517 GO:0002020 protease binding 11/918 136/18639 0.0808823529411765 1.64222895040369 0.0726148139450129 0.402302762316048 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/918 60/18639 0.1 2.03039215686274 0.0740670706888675 0.408003749394676 GO:0019956 chemokine binding 4/918 33/18639 0.121212121212121 2.46108140225787 0.077215171390384 0.412335699033417 GO:0030296 protein tyrosine kinase activator activity 4/918 33/18639 0.121212121212121 2.46108140225787 0.077215171390384 0.412335699033417 GO:0071889 14-3-3 protein binding 4/918 33/18639 0.121212121212121 2.46108140225787 0.077215171390384 0.412335699033417 GO:0141108 transporter regulator activity 13/918 170/18639 0.0764705882352941 1.55265282583622 0.0772611947122847 0.412335699033417 GO:0098631 cell adhesion mediator activity 7/918 76/18639 0.0921052631578947 1.87009803921569 0.0800699618177001 0.412335699033417 GO:0005504 fatty acid binding 5/918 47/18639 0.106382978723404 2.15999165623696 0.0801691386777122 0.412335699033417 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/918 21/18639 0.142857142857143 2.90056022408964 0.0818692704528239 0.412335699033417 GO:0005123 death receptor binding 3/918 21/18639 0.142857142857143 2.90056022408964 0.0818692704528239 0.412335699033417 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/918 21/18639 0.142857142857143 2.90056022408964 0.0818692704528239 0.412335699033417 GO:0070182 DNA polymerase binding 3/918 21/18639 0.142857142857143 2.90056022408964 0.0818692704528239 0.412335699033417 GO:0072542 protein phosphatase activator activity 3/918 21/18639 0.142857142857143 2.90056022408964 0.0818692704528239 0.412335699033417 GO:0004955 prostaglandin receptor activity 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0005131 growth hormone receptor binding 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0005528 FK506 binding 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0008239 dipeptidyl-peptidase activity 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0016868 intramolecular phosphotransferase activity 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0030957 Tat protein binding 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0043422 protein kinase B binding 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0097177 mitochondrial ribosome binding 2/918 10/18639 0.2 4.06078431372549 0.0838695117272538 0.412335699033417 GO:0051427 hormone receptor binding 4/918 34/18639 0.117647058823529 2.38869665513264 0.084263623142721 0.412335699033417 GO:0090482 vitamin transmembrane transporter activity 4/918 34/18639 0.117647058823529 2.38869665513264 0.084263623142721 0.412335699033417 GO:0005126 cytokine receptor binding 19/918 275/18639 0.0690909090909091 1.40281639928699 0.0867475951335905 0.422346877317077 GO:0061133 endopeptidase activator activity 3/918 22/18639 0.136363636363636 2.76871657754011 0.0914742825667069 0.439384519931885 GO:0140517 protein-RNA adaptor activity 3/918 22/18639 0.136363636363636 2.76871657754011 0.0914742825667069 0.439384519931885 GO:0016229 steroid dehydrogenase activity 4/918 35/18639 0.114285714285714 2.32044817927171 0.0916144071642209 0.439384519931885 GO:0042826 histone deacetylase binding 10/918 127/18639 0.078740157480315 1.59873398178169 0.0964667800592155 0.448925581914358 GO:0099106 ion channel regulator activity 12/918 160/18639 0.075 1.52279411764706 0.097106119324921 0.448925581914358 GO:0000049 tRNA binding 7/918 80/18639 0.0875 1.7765931372549 0.0987839914388038 0.448925581914358 GO:0019955 cytokine binding 11/918 144/18639 0.0763888888888889 1.5509940087146 0.0989299214086518 0.448925581914358 GO:0004954 prostanoid receptor activity 2/918 11/18639 0.181818181818182 3.69162210338681 0.099263696962137 0.448925581914358 GO:0005536 D-glucose binding 2/918 11/18639 0.181818181818182 3.69162210338681 0.099263696962137 0.448925581914358 GO:0008046 axon guidance receptor activity 2/918 11/18639 0.181818181818182 3.69162210338681 0.099263696962137 0.448925581914358 GO:0008432 JUN kinase binding 2/918 11/18639 0.181818181818182 3.69162210338681 0.099263696962137 0.448925581914358 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/918 11/18639 0.181818181818182 3.69162210338681 0.099263696962137 0.448925581914358 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/918 11/18639 0.181818181818182 3.69162210338681 0.099263696962137 0.448925581914358 GO:0042608 T cell receptor binding 2/918 11/18639 0.181818181818182 3.69162210338681 0.099263696962137 0.448925581914358 GO:0070990 snRNP binding 2/918 11/18639 0.181818181818182 3.69162210338681 0.099263696962137 0.448925581914358 GO:0038024 cargo receptor activity 6/918 65/18639 0.0923076923076923 1.87420814479638 0.0999707589161714 0.448925581914358 GO:0004602 glutathione peroxidase activity 3/918 23/18639 0.130434782608696 2.64833759590793 0.101520515412168 0.448925581914358 GO:0005158 insulin receptor binding 3/918 23/18639 0.130434782608696 2.64833759590793 0.101520515412168 0.448925581914358 GO:0005212 structural constituent of eye lens 3/918 23/18639 0.130434782608696 2.64833759590793 0.101520515412168 0.448925581914358 GO:0031681 G-protein beta-subunit binding 3/918 23/18639 0.130434782608696 2.64833759590793 0.101520515412168 0.448925581914358 GO:0005048 signal sequence binding 5/918 51/18639 0.0980392156862745 1.99058054594387 0.105007320148242 0.462224002844314 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/918 52/18639 0.0961538461538462 1.95230015082956 0.111746717766263 0.485769081949091 GO:0050431 transforming growth factor beta binding 3/918 24/18639 0.125 2.53799019607843 0.111982720107419 0.485769081949091 GO:0060229 lipase activator activity 3/918 24/18639 0.125 2.53799019607843 0.111982720107419 0.485769081949091 GO:0005049 nuclear export signal receptor activity 2/918 12/18639 0.166666666666667 3.38398692810458 0.115364619754078 0.485769081949091 GO:0005527 macrolide binding 2/918 12/18639 0.166666666666667 3.38398692810458 0.115364619754078 0.485769081949091 GO:0015132 prostaglandin transmembrane transporter activity 2/918 12/18639 0.166666666666667 3.38398692810458 0.115364619754078 0.485769081949091 GO:0035497 cAMP response element binding 2/918 12/18639 0.166666666666667 3.38398692810458 0.115364619754078 0.485769081949091 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/918 12/18639 0.166666666666667 3.38398692810458 0.115364619754078 0.485769081949091 GO:0005501 retinoid binding 4/918 38/18639 0.105263157894737 2.13725490196078 0.115395352454712 0.485769081949091 GO:0019840 isoprenoid binding 4/918 38/18639 0.105263157894737 2.13725490196078 0.115395352454712 0.485769081949091 GO:0005251 delayed rectifier potassium channel activity 3/918 25/18639 0.12 2.43647058823529 0.122835025322038 0.51261023554305 GO:0008483 transaminase activity 3/918 25/18639 0.12 2.43647058823529 0.122835025322038 0.51261023554305 GO:0051287 NAD binding 5/918 54/18639 0.0925925925925926 1.87999273783587 0.125829344493198 0.522842621083805 GO:0016209 antioxidant activity 7/918 86/18639 0.0813953488372093 1.65264477884177 0.13092470394681 0.530463112506359 GO:0005172 vascular endothelial growth factor receptor binding 2/918 13/18639 0.153846153846154 3.1236802413273 0.132065505188305 0.530463112506359 GO:0019855 calcium channel inhibitor activity 2/918 13/18639 0.153846153846154 3.1236802413273 0.132065505188305 0.530463112506359 GO:0031994 insulin-like growth factor I binding 2/918 13/18639 0.153846153846154 3.1236802413273 0.132065505188305 0.530463112506359 GO:0070700 BMP receptor binding 2/918 13/18639 0.153846153846154 3.1236802413273 0.132065505188305 0.530463112506359 GO:0071714 icosanoid transmembrane transporter activity 2/918 13/18639 0.153846153846154 3.1236802413273 0.132065505188305 0.530463112506359 GO:0071837 HMG box domain binding 2/918 13/18639 0.153846153846154 3.1236802413273 0.132065505188305 0.530463112506359 GO:0089720 caspase binding 2/918 13/18639 0.153846153846154 3.1236802413273 0.132065505188305 0.530463112506359 GO:0098632 cell-cell adhesion mediator activity 5/918 55/18639 0.0909090909090909 1.8458110516934 0.133161974389892 0.532647897559567 GO:0044325 transmembrane transporter binding 10/918 136/18639 0.0735294117647059 1.4929354094579 0.134065733231813 0.534046970394493 GO:0170055 lipid transmembrane transporter activity 5/918 56/18639 0.0892857142857143 1.81285014005602 0.140681218922134 0.558093395230194 GO:0001671 ATPase activator activity 3/918 27/18639 0.111111111111111 2.25599128540305 0.145604647229905 0.568270768945865 GO:0005044 scavenger receptor activity 3/918 27/18639 0.111111111111111 2.25599128540305 0.145604647229905 0.568270768945865 GO:0008320 protein transmembrane transporter activity 3/918 27/18639 0.111111111111111 2.25599128540305 0.145604647229905 0.568270768945865 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/918 27/18639 0.111111111111111 2.25599128540305 0.145604647229905 0.568270768945865 GO:0003727 single-stranded RNA binding 7/918 89/18639 0.0786516853932584 1.59693765146508 0.148725634207439 0.575578802523361 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/918 14/18639 0.142857142857143 2.90056022408964 0.149268361650249 0.575578802523361 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/918 14/18639 0.142857142857143 2.90056022408964 0.149268361650249 0.575578802523361 GO:0019789 SUMO transferase activity 3/918 28/18639 0.107142857142857 2.17542016806723 0.157468984229122 0.600000398406617 GO:0045499 chemorepellent activity 3/918 28/18639 0.107142857142857 2.17542016806723 0.157468984229122 0.600000398406617 GO:0046875 ephrin receptor binding 3/918 28/18639 0.107142857142857 2.17542016806723 0.157468984229122 0.600000398406617 GO:0008200 ion channel inhibitor activity 4/918 43/18639 0.0930232558139535 1.88873689010488 0.160190190312084 0.605581739062154 GO:0048156 tau protein binding 4/918 43/18639 0.0930232558139535 1.88873689010488 0.160190190312084 0.605581739062154 GO:0033218 amide binding 16/918 247/18639 0.0647773279352227 1.31523378582202 0.160887626330177 0.605842467899572 GO:0005085 guanyl-nucleotide exchange factor activity 15/918 230/18639 0.0652173913043478 1.32416879795396 0.164127345128722 0.607376554228689 GO:0004953 icosanoid receptor activity 2/918 15/18639 0.133333333333333 2.70718954248366 0.166883376172434 0.607376554228689 GO:0005041 low-density lipoprotein particle receptor activity 2/918 15/18639 0.133333333333333 2.70718954248366 0.166883376172434 0.607376554228689 GO:0005523 tropomyosin binding 2/918 15/18639 0.133333333333333 2.70718954248366 0.166883376172434 0.607376554228689 GO:0015929 hexosaminidase activity 2/918 15/18639 0.133333333333333 2.70718954248366 0.166883376172434 0.607376554228689 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/918 15/18639 0.133333333333333 2.70718954248366 0.166883376172434 0.607376554228689 GO:0031005 filamin binding 2/918 15/18639 0.133333333333333 2.70718954248366 0.166883376172434 0.607376554228689 GO:0033130 acetylcholine receptor binding 2/918 15/18639 0.133333333333333 2.70718954248366 0.166883376172434 0.607376554228689 GO:0043178 alcohol binding 7/918 92/18639 0.0760869565217391 1.54486359761296 0.167595605212481 0.607376554228689 GO:0052689 carboxylic ester hydrolase activity 7/918 92/18639 0.0760869565217391 1.54486359761296 0.167595605212481 0.607376554228689 GO:0003785 actin monomer binding 3/918 29/18639 0.103448275862069 2.10040567951318 0.16961778913579 0.608584194132751 GO:0051861 glycolipid binding 3/918 29/18639 0.103448275862069 2.10040567951318 0.16961778913579 0.608584194132751 GO:0016248 channel inhibitor activity 4/918 44/18639 0.0909090909090909 1.8458110516934 0.169822767864844 0.608584194132751 GO:0141110 transporter inhibitor activity 4/918 45/18639 0.0888888888888889 1.80479302832244 0.179652053947853 0.641424370391595 GO:0001965 G-protein alpha-subunit binding 3/918 30/18639 0.1 2.03039215686274 0.182024937785225 0.647498302675117 GO:0005159 insulin-like growth factor receptor binding 2/918 16/18639 0.125 2.53799019607843 0.18482834793461 0.647907372396233 GO:0008142 oxysterol binding 2/918 16/18639 0.125 2.53799019607843 0.18482834793461 0.647907372396233 GO:0016722 oxidoreductase activity, acting on metal ions 2/918 16/18639 0.125 2.53799019607843 0.18482834793461 0.647907372396233 GO:0022841 potassium ion leak channel activity 2/918 16/18639 0.125 2.53799019607843 0.18482834793461 0.647907372396233 GO:0005200 structural constituent of cytoskeleton 8/918 112/18639 0.0714285714285714 1.45028011204482 0.187217821076468 0.653905722890273 GO:0033293 monocarboxylic acid binding 6/918 79/18639 0.0759493670886076 1.54206999255398 0.193342355516703 0.672859316671848 GO:0005164 tumor necrosis factor receptor binding 3/918 31/18639 0.0967741935483871 1.96489563567362 0.194664679396605 0.675024283950816 GO:0031072 heat shock protein binding 9/918 131/18639 0.0687022900763359 1.39492590929502 0.197416727883708 0.682113712114319 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/918 17/18639 0.117647058823529 2.38869665513264 0.203028157631886 0.686733838446099 GO:0016018 cyclosporin A binding 2/918 17/18639 0.117647058823529 2.38869665513264 0.203028157631886 0.686733838446099 GO:0017110 nucleoside diphosphate phosphatase activity 2/918 17/18639 0.117647058823529 2.38869665513264 0.203028157631886 0.686733838446099 GO:0030169 low-density lipoprotein particle binding 2/918 17/18639 0.117647058823529 2.38869665513264 0.203028157631886 0.686733838446099 GO:0032977 membrane insertase activity 2/918 17/18639 0.117647058823529 2.38869665513264 0.203028157631886 0.686733838446099 GO:0038191 neuropilin binding 2/918 17/18639 0.117647058823529 2.38869665513264 0.203028157631886 0.686733838446099 GO:0022884 macromolecule transmembrane transporter activity 3/918 32/18639 0.09375 1.90349264705882 0.207511737017788 0.689797636155683 GO:0031369 translation initiation factor binding 3/918 32/18639 0.09375 1.90349264705882 0.207511737017788 0.689797636155683 GO:0051059 NF-kappaB binding 3/918 32/18639 0.09375 1.90349264705882 0.207511737017788 0.689797636155683 GO:0120015 sterol transfer activity 3/918 32/18639 0.09375 1.90349264705882 0.207511737017788 0.689797636155683 GO:0140142 nucleocytoplasmic carrier activity 3/918 32/18639 0.09375 1.90349264705882 0.207511737017788 0.689797636155683 GO:0140693 molecular condensate scaffold activity 4/918 48/18639 0.0833333333333333 1.69199346405229 0.210196819107579 0.696322108658785 GO:0031406 carboxylic acid binding 12/918 187/18639 0.0641711229946524 1.30292544825417 0.21223083379219 0.700652478683804 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/918 33/18639 0.0909090909090909 1.8458110516934 0.220541393580529 0.721092421681457 GO:0060590 ATPase regulator activity 4/918 49/18639 0.0816326530612245 1.65746298519408 0.220689318928552 0.721092421681457 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/918 18/18639 0.111111111111111 2.25599128540305 0.221414270557792 0.721092421681457 GO:0030228 lipoprotein particle receptor activity 2/918 18/18639 0.111111111111111 2.25599128540305 0.221414270557792 0.721092421681457 GO:0043177 organic acid binding 12/918 189/18639 0.0634920634920635 1.28913787737317 0.222502130020051 0.722195465788987 GO:0051117 ATPase binding 6/918 84/18639 0.0714285714285714 1.45028011204482 0.23271949254027 0.752824130230939 GO:0030332 cyclin binding 3/918 34/18639 0.0882352941176471 1.79152249134948 0.23372956491322 0.753562878181752 GO:0008238 exopeptidase activity 7/918 102/18639 0.0686274509803922 1.39340638216071 0.237164094960098 0.758318024932711 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/918 19/18639 0.105263157894737 2.13725490196078 0.239924271373939 0.758318024932711 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/918 19/18639 0.105263157894737 2.13725490196078 0.239924271373939 0.758318024932711 GO:0022840 leak channel activity 2/918 19/18639 0.105263157894737 2.13725490196078 0.239924271373939 0.758318024932711 GO:0022842 narrow pore channel activity 2/918 19/18639 0.105263157894737 2.13725490196078 0.239924271373939 0.758318024932711 GO:0043395 heparan sulfate proteoglycan binding 2/918 19/18639 0.105263157894737 2.13725490196078 0.239924271373939 0.758318024932711 GO:0016004 phospholipase activator activity 2/918 20/18639 0.1 2.03039215686274 0.258501428655632 0.811711326462635 GO:0042288 MHC class I protein binding 2/918 20/18639 0.1 2.03039215686274 0.258501428655632 0.811711326462635 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/918 70/18639 0.0714285714285714 1.45028011204482 0.261793698561587 0.819380277316135 GO:0016251 RNA polymerase II general transcription initiation factor activity 4/918 53/18639 0.0754716981132075 1.53237143914169 0.263884420502253 0.820595423755392 GO:0140296 general transcription initiation factor binding 4/918 53/18639 0.0754716981132075 1.53237143914169 0.263884420502253 0.820595423755392 GO:0001846 opsonin binding 2/918 21/18639 0.0952380952380952 1.93370681605976 0.277094287413821 0.850697111678102 GO:0035613 RNA stem-loop binding 2/918 21/18639 0.0952380952380952 1.93370681605976 0.277094287413821 0.850697111678102 GO:0036122 BMP binding 2/918 21/18639 0.0952380952380952 1.93370681605976 0.277094287413821 0.850697111678102 GO:0051428 peptide hormone receptor binding 2/918 21/18639 0.0952380952380952 1.93370681605976 0.277094287413821 0.850697111678102 GO:0032931 histone H3K56 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0043992 histone H3K9 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0043993 histone H3K18 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0043994 histone H3K23 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0043999 histone H2AK5 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0044012 histone H2AK9 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0044014 histone H2BK5 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0044015 histone H2BK12 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0044016 histone H3K4 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0044017 histone H3K27 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0044018 histone H3K36 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0046972 histone H4K16 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0140908 histone H3K122 acetyltransferase activity 2/918 22/18639 0.0909090909090909 1.8458110516934 0.295656287898533 0.868136752737418 GO:0031490 chromatin DNA binding 8/918 128/18639 0.0625 1.26899509803922 0.295889675113878 0.868136752737418 GO:0001217 DNA-binding transcription repressor activity 16/918 278/18639 0.0575539568345324 1.16857102553252 0.296283186359555 0.868136752737418 GO:0008237 metallopeptidase activity 11/918 184/18639 0.0597826086956522 1.21382139812447 0.297935810094937 0.870333699792483 GO:0004601 peroxidase activity 4/918 57/18639 0.0701754385964912 1.42483660130719 0.308463712766223 0.874563231839641 GO:0051213 dioxygenase activity 6/918 93/18639 0.0645161290322581 1.30993042378242 0.308766210584236 0.874563231839641 GO:0019003 GDP binding 5/918 75/18639 0.0666666666666667 1.35359477124183 0.309899884154783 0.874563231839641 GO:0003887 DNA-directed DNA polymerase activity 2/918 23/18639 0.0869565217391304 1.76555839727195 0.314145409087711 0.874563231839641 GO:0044013 histone H2B acetyltransferase activity 2/918 23/18639 0.0869565217391304 1.76555839727195 0.314145409087711 0.874563231839641 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/918 23/18639 0.0869565217391304 1.76555839727195 0.314145409087711 0.874563231839641 GO:0015144 carbohydrate transmembrane transporter activity 3/918 40/18639 0.075 1.52279411764706 0.314931743676374 0.874563231839641 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/918 40/18639 0.075 1.52279411764706 0.314931743676374 0.874563231839641 GO:0030331 nuclear estrogen receptor binding 3/918 40/18639 0.075 1.52279411764706 0.314931743676374 0.874563231839641 GO:0071855 neuropeptide receptor binding 3/918 40/18639 0.075 1.52279411764706 0.314931743676374 0.874563231839641 GO:0071949 FAD binding 3/918 40/18639 0.075 1.52279411764706 0.314931743676374 0.874563231839641 GO:0019842 vitamin binding 9/918 150/18639 0.06 1.21823529411765 0.320141361272923 0.874563231839641 GO:0140597 protein carrier chaperone 11/918 188/18639 0.0585106382978723 1.18799541093033 0.322334239336774 0.874563231839641 GO:0140318 protein transporter activity 3/918 41/18639 0.0731707317073171 1.48565279770445 0.328618704032932 0.874563231839641 GO:0003724 RNA helicase activity 5/918 77/18639 0.0649350649350649 1.31843646549529 0.329492448084136 0.874563231839641 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 4/918 59/18639 0.0677966101694915 1.37653705550017 0.331043270924201 0.874563231839641 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0015149 hexose transmembrane transporter activity 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0015295 solute:proton symporter activity 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0019957 C-C chemokine binding 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0030215 semaphorin receptor binding 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0035035 histone acetyltransferase binding 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0043998 histone H2A acetyltransferase activity 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0050699 WW domain binding 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0055056 D-glucose transmembrane transporter activity 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/918 24/18639 0.0833333333333333 1.69199346405229 0.332523835358646 0.874563231839641 GO:0004402 histone acetyltransferase activity 3/918 42/18639 0.0714285714285714 1.45028011204482 0.342299644800462 0.874563231839641 GO:0031492 nucleosomal DNA binding 3/918 42/18639 0.0714285714285714 1.45028011204482 0.342299644800462 0.874563231839641 GO:0042056 chemoattractant activity 3/918 42/18639 0.0714285714285714 1.45028011204482 0.342299644800462 0.874563231839641 GO:0001098 basal transcription machinery binding 4/918 60/18639 0.0666666666666667 1.35359477124183 0.342367824036279 0.874563231839641 GO:0001099 basal RNA polymerase II transcription machinery binding 4/918 60/18639 0.0666666666666667 1.35359477124183 0.342367824036279 0.874563231839641 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/918 60/18639 0.0666666666666667 1.35359477124183 0.342367824036279 0.874563231839641 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 15/918 268/18639 0.0559701492537313 1.13641352063213 0.342575473287932 0.874563231839641 GO:0140104 molecular carrier activity 14/918 249/18639 0.0562248995983936 1.14158595164974 0.343941395658773 0.874563231839641 GO:0000287 magnesium ion binding 13/918 230/18639 0.0565217391304348 1.14761295822677 0.345187650012397 0.874563231839641 GO:0008186 ATP-dependent activity, acting on RNA 5/918 79/18639 0.0632911392405063 1.28505832712832 0.349199485615203 0.874563231839641 GO:0046332 SMAD binding 5/918 79/18639 0.0632911392405063 1.28505832712832 0.349199485615203 0.874563231839641 GO:0001848 complement binding 2/918 25/18639 0.08 1.6243137254902 0.350757644927047 0.874563231839641 GO:0008139 nuclear localization sequence binding 2/918 25/18639 0.08 1.6243137254902 0.350757644927047 0.874563231839641 GO:0015662 P-type ion transporter activity 2/918 25/18639 0.08 1.6243137254902 0.350757644927047 0.874563231839641 GO:0017025 TBP-class protein binding 2/918 25/18639 0.08 1.6243137254902 0.350757644927047 0.874563231839641 GO:0120020 cholesterol transfer activity 2/918 25/18639 0.08 1.6243137254902 0.350757644927047 0.874563231839641 GO:0140358 P-type transmembrane transporter activity 2/918 25/18639 0.08 1.6243137254902 0.350757644927047 0.874563231839641 GO:0016779 nucleotidyltransferase activity 8/918 136/18639 0.0588235294117647 1.19434832756632 0.35504753288551 0.874563231839641 GO:0004435 phosphatidylinositol phospholipase C activity 2/918 26/18639 0.0769230769230769 1.56184012066365 0.368816518721723 0.874563231839641 GO:0008143 poly(A) binding 2/918 26/18639 0.0769230769230769 1.56184012066365 0.368816518721723 0.874563231839641 GO:0008198 ferrous iron binding 2/918 26/18639 0.0769230769230769 1.56184012066365 0.368816518721723 0.874563231839641 GO:0015145 monosaccharide transmembrane transporter activity 2/918 26/18639 0.0769230769230769 1.56184012066365 0.368816518721723 0.874563231839641 GO:0015216 purine nucleotide transmembrane transporter activity 2/918 26/18639 0.0769230769230769 1.56184012066365 0.368816518721723 0.874563231839641 GO:0019865 immunoglobulin binding 2/918 26/18639 0.0769230769230769 1.56184012066365 0.368816518721723 0.874563231839641 GO:0030247 polysaccharide binding 2/918 26/18639 0.0769230769230769 1.56184012066365 0.368816518721723 0.874563231839641 GO:0097602 cullin family protein binding 2/918 26/18639 0.0769230769230769 1.56184012066365 0.368816518721723 0.874563231839641 GO:0001618 virus receptor activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:0033192 calmodulin-dependent protein phosphatase activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:0140791 histone H2AXS140 phosphatase activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/918 81/18639 0.0617283950617284 1.25332849189058 0.368966560764963 0.874563231839641 GO:0070851 growth factor receptor binding 8/918 139/18639 0.0575539568345324 1.16857102553252 0.377612901154225 0.874563231839641 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/918 82/18639 0.0609756097560976 1.23804399808704 0.378856217406829 0.874563231839641 GO:0033549 MAP kinase phosphatase activity 5/918 82/18639 0.0609756097560976 1.23804399808704 0.378856217406829 0.874563231839641 GO:0140272 exogenous protein binding 5/918 82/18639 0.0609756097560976 1.23804399808704 0.378856217406829 0.874563231839641 GO:0005319 lipid transporter activity 10/918 178/18639 0.0561797752808989 1.14066975104649 0.380898996493362 0.874563231839641 GO:0003713 transcription coactivator activity 14/918 256/18639 0.0546875 1.11037071078431 0.382526520282018 0.874563231839641 GO:0004364 glutathione transferase activity 2/918 27/18639 0.0740740740740741 1.5039941902687 0.386673468441069 0.874563231839641 GO:0008266 poly(U) RNA binding 2/918 27/18639 0.0740740740740741 1.5039941902687 0.386673468441069 0.874563231839641 GO:0035255 ionotropic glutamate receptor binding 2/918 27/18639 0.0740740740740741 1.5039941902687 0.386673468441069 0.874563231839641 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5/918 83/18639 0.0602409638554217 1.223127805339 0.388741514921696 0.874563231839641 GO:0003712 transcription coregulator activity 26/918 495/18639 0.0525252525252525 1.06646860764508 0.395857578370259 0.874563231839641 GO:0000182 rDNA binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0001094 TFIID-class transcription factor complex binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0004382 GDP phosphatase activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0005381 iron ion transmembrane transporter activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0005522 profilin binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0015279 store-operated calcium channel activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0019911 structural constituent of myelin sheath 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0031434 mitogen-activated protein kinase kinase binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0031996 thioesterase binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0032052 bile acid binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0032356 oxidized DNA binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0035256 G protein-coupled glutamate receptor binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0035374 chondroitin sulfate binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0043295 glutathione binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0098505 G-rich strand telomeric DNA binding 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0140999 histone H3K4 trimethyltransferase activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0141109 transporter activator activity 1/918 10/18639 0.1 2.03039215686274 0.396604818968954 0.874563231839641 GO:0004180 carboxypeptidase activity 3/918 46/18639 0.0652173913043478 1.32416879795396 0.396642051302114 0.874563231839641 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/918 46/18639 0.0652173913043478 1.32416879795396 0.396642051302114 0.874563231839641 GO:0004722 protein serine/threonine phosphatase activity 6/918 103/18639 0.058252427184466 1.18275271273558 0.397132370941886 0.874563231839641 GO:0017018 myosin phosphatase activity 5/918 84/18639 0.0595238095238095 1.20856676003735 0.398616326464825 0.874563231839641 GO:0016866 intramolecular transferase activity 2/918 28/18639 0.0714285714285714 1.45028011204482 0.404304582611219 0.874563231839641 GO:0036408 histone H3K14 acetyltransferase activity 2/918 28/18639 0.0714285714285714 1.45028011204482 0.404304582611219 0.874563231839641 GO:0051119 sugar transmembrane transporter activity 2/918 28/18639 0.0714285714285714 1.45028011204482 0.404304582611219 0.874563231839641 GO:0001784 phosphotyrosine residue binding 3/918 47/18639 0.0638297872340425 1.29599499374218 0.410059589775312 0.874563231839641 GO:0061733 protein-lysine-acetyltransferase activity 3/918 47/18639 0.0638297872340425 1.29599499374218 0.410059589775312 0.874563231839641 GO:0008235 metalloexopeptidase activity 4/918 66/18639 0.0606060606060606 1.23054070112894 0.410184961597859 0.874563231839641 GO:0004181 metallocarboxypeptidase activity 2/918 29/18639 0.0689655172413793 1.40027045300879 0.421688789535325 0.874563231839641 GO:0010484 histone H3 acetyltransferase activity 2/918 29/18639 0.0689655172413793 1.40027045300879 0.421688789535325 0.874563231839641 GO:0003714 transcription corepressor activity 11/918 204/18639 0.053921568627451 1.09481930026913 0.423002645574255 0.874563231839641 GO:0008013 beta-catenin binding 6/918 106/18639 0.0566037735849057 1.14927857935627 0.423734755181265 0.874563231839641 GO:0042578 phosphoric ester hydrolase activity 19/918 363/18639 0.0523415977961433 1.06273969642954 0.425891597634538 0.874563231839641 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0003953 NAD+ nucleosidase activity 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0008199 ferric iron binding 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0010854 adenylate cyclase regulator activity 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0015217 ADP transmembrane transporter activity 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0019206 nucleoside kinase activity 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0019215 intermediate filament binding 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0019864 IgG binding 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0031731 CCR6 chemokine receptor binding 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0034056 estrogen response element binding 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0097493 structural molecule activity conferring elasticity 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:1900750 oligopeptide binding 1/918 11/18639 0.0909090909090909 1.8458110516934 0.426338931169636 0.874563231839641 GO:0032934 sterol binding 4/918 68/18639 0.0588235294117647 1.19434832756632 0.432527742591398 0.874563231839641 GO:0140223 general transcription initiation factor activity 4/918 68/18639 0.0588235294117647 1.19434832756632 0.432527742591398 0.874563231839641 GO:0019783 ubiquitin-like protein peptidase activity 7/918 127/18639 0.0551181102362205 1.11911378724718 0.43569956269466 0.874563231839641 GO:0001222 transcription corepressor binding 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0005004 GPI-linked ephrin receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0005008 hepatocyte growth factor receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0005009 insulin receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0005011 macrophage colony-stimulating factor receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0005020 stem cell factor receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0008288 boss receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0016763 pentosyltransferase activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0035254 glutamate receptor binding 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0036332 placental growth factor receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0038062 protein tyrosine kinase collagen receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0060175 brain-derived neurotrophic factor receptor activity 3/918 49/18639 0.0612244897959184 1.24309723889556 0.436602978109837 0.874563231839641 GO:0008187 poly-pyrimidine tract binding 2/918 30/18639 0.0666666666666667 1.35359477124183 0.438807636088903 0.874563231839641 GO:0015215 nucleotide transmembrane transporter activity 2/918 30/18639 0.0666666666666667 1.35359477124183 0.438807636088903 0.874563231839641 GO:0031210 phosphatidylcholine binding 2/918 30/18639 0.0666666666666667 1.35359477124183 0.438807636088903 0.874563231839641 GO:0033612 receptor serine/threonine kinase binding 2/918 30/18639 0.0666666666666667 1.35359477124183 0.438807636088903 0.874563231839641 GO:0043995 histone H4K5 acetyltransferase activity 2/918 30/18639 0.0666666666666667 1.35359477124183 0.438807636088903 0.874563231839641 GO:0043996 histone H4K8 acetyltransferase activity 2/918 30/18639 0.0666666666666667 1.35359477124183 0.438807636088903 0.874563231839641 GO:0043997 histone H4K12 acetyltransferase activity 2/918 30/18639 0.0666666666666667 1.35359477124183 0.438807636088903 0.874563231839641 GO:0070566 adenylyltransferase activity 2/918 30/18639 0.0666666666666667 1.35359477124183 0.438807636088903 0.874563231839641 GO:0005496 steroid binding 6/918 108/18639 0.0555555555555556 1.12799564270152 0.441382030355315 0.874563231839641 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 5/918 89/18639 0.0561797752808989 1.14066975104649 0.447630662744456 0.874563231839641 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 5/918 89/18639 0.0561797752808989 1.14066975104649 0.447630662744456 0.874563231839641 GO:0005006 epidermal growth factor receptor activity 3/918 50/18639 0.06 1.21823529411765 0.449706364485592 0.874563231839641 GO:0005007 fibroblast growth factor receptor activity 3/918 50/18639 0.06 1.21823529411765 0.449706364485592 0.874563231839641 GO:0005017 platelet-derived growth factor receptor activity 3/918 50/18639 0.06 1.21823529411765 0.449706364485592 0.874563231839641 GO:0005019 platelet-derived growth factor beta-receptor activity 3/918 50/18639 0.06 1.21823529411765 0.449706364485592 0.874563231839641 GO:0004620 phospholipase activity 6/918 109/18639 0.055045871559633 1.11764705882353 0.450167193525513 0.874563231839641 GO:0030695 GTPase regulator activity 25/918 489/18639 0.0511247443762781 1.03803280003208 0.453008046319773 0.874563231839641 GO:0004032 aldose reductase (NADPH) activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0008603 cAMP-dependent protein kinase regulator activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0010853 cyclase activator activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0016801 hydrolase activity, acting on ether bonds 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0016803 ether hydrolase activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0016840 carbon-nitrogen lyase activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0043047 single-stranded telomeric DNA binding 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0070008 serine-type exopeptidase activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/918 12/18639 0.0833333333333333 1.69199346405229 0.454609323116505 0.874563231839641 GO:0097110 scaffold protein binding 4/918 70/18639 0.0571428571428571 1.16022408963585 0.454633063330137 0.874563231839641 GO:0008327 methyl-CpG binding 2/918 31/18639 0.0645161290322581 1.30993042378242 0.455645081378028 0.874563231839641 GO:0072349 modified amino acid transmembrane transporter activity 2/918 31/18639 0.0645161290322581 1.30993042378242 0.455645081378028 0.874563231839641 GO:0060589 nucleoside-triphosphatase regulator activity 25/918 490/18639 0.0510204081632653 1.0359143657463 0.457161078974373 0.874563231839641 GO:0140793 histone H2AXY142 phosphatase activity 5/918 90/18639 0.0555555555555556 1.12799564270152 0.457323596160826 0.874563231839641 GO:0016298 lipase activity 7/918 130/18639 0.0538461538461538 1.09328808446456 0.459901502119141 0.874563231839641 GO:0005010 insulin-like growth factor receptor activity 3/918 51/18639 0.0588235294117647 1.19434832756632 0.46268386746703 0.874563231839641 GO:0005021 vascular endothelial growth factor receptor activity 3/918 51/18639 0.0588235294117647 1.19434832756632 0.46268386746703 0.874563231839641 GO:0005030 neurotrophin receptor activity 3/918 51/18639 0.0588235294117647 1.19434832756632 0.46268386746703 0.874563231839641 GO:0005272 sodium channel activity 3/918 51/18639 0.0588235294117647 1.19434832756632 0.46268386746703 0.874563231839641 GO:0030544 Hsp70 protein binding 3/918 51/18639 0.0588235294117647 1.19434832756632 0.46268386746703 0.874563231839641 GO:0072341 modified amino acid binding 5/918 91/18639 0.0549450549450549 1.11560008618832 0.46696807748797 0.875763033065175 GO:0042910 xenobiotic transmembrane transporter activity 2/918 32/18639 0.0625 1.26899509803922 0.472187304335377 0.875763033065175 GO:0070717 poly-purine tract binding 2/918 32/18639 0.0625 1.26899509803922 0.472187304335377 0.875763033065175 GO:0005080 protein kinase C binding 3/918 52/18639 0.0576923076923077 1.17138009049774 0.475526168534362 0.875763033065175 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0005035 death receptor activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0008035 high-density lipoprotein particle binding 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0008253 5'-nucleotidase activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0017154 semaphorin receptor activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0030955 potassium ion binding 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0031432 titin binding 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0035325 Toll-like receptor binding 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0035673 oligopeptide transmembrane transporter activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0045159 myosin II binding 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0046975 histone H3K36 methyltransferase activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0051011 microtubule minus-end binding 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/918 13/18639 0.0769230769230769 1.56184012066365 0.481487974610521 0.875763033065175 GO:0005003 ephrin receptor activity 3/918 53/18639 0.0566037735849057 1.14927857935627 0.488224673416289 0.881364391710304 GO:0005005 transmembrane-ephrin receptor activity 3/918 53/18639 0.0566037735849057 1.14927857935627 0.488224673416289 0.881364391710304 GO:0034212 protein N-acetyltransferase activity 3/918 53/18639 0.0566037735849057 1.14927857935627 0.488224673416289 0.881364391710304 GO:0038064 collagen receptor activity 3/918 53/18639 0.0566037735849057 1.14927857935627 0.488224673416289 0.881364391710304 GO:0003925 G protein activity 3/918 54/18639 0.0555555555555556 1.12799564270152 0.500771487935895 0.885488713031321 GO:0015485 cholesterol binding 3/918 54/18639 0.0555555555555556 1.12799564270152 0.500771487935895 0.885488713031321 GO:0017069 snRNA binding 3/918 54/18639 0.0555555555555556 1.12799564270152 0.500771487935895 0.885488713031321 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/918 54/18639 0.0555555555555556 1.12799564270152 0.500771487935895 0.885488713031321 GO:0001221 transcription coregulator binding 6/918 115/18639 0.0521739130434783 1.05933503836317 0.502104802017658 0.885488713031321 GO:0101005 deubiquitinase activity 6/918 115/18639 0.0521739130434783 1.05933503836317 0.502104802017658 0.885488713031321 GO:0008376 acetylgalactosaminyltransferase activity 2/918 34/18639 0.0588235294117647 1.19434832756632 0.504340834351005 0.885488713031321 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/918 34/18639 0.0588235294117647 1.19434832756632 0.504340834351005 0.885488713031321 GO:0005347 ATP transmembrane transporter activity 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0005545 1-phosphatidylinositol binding 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0008195 phosphatidate phosphatase activity 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0008494 translation activator activity 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0008559 ABC-type xenobiotic transporter activity 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0015926 glucosidase activity 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0031404 chloride ion binding 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0061665 SUMO ligase activity 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0070742 C2H2 zinc finger domain binding 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0098847 sequence-specific single stranded DNA binding 1/918 14/18639 0.0714285714285714 1.45028011204482 0.507043329453619 0.885488713031321 GO:0004896 cytokine receptor activity 5/918 96/18639 0.0520833333333333 1.05749591503268 0.514306264017147 0.896548351740559 GO:0010485 histone H4 acetyltransferase activity 2/918 35/18639 0.0571428571428571 1.16022408963585 0.519934044860024 0.899849944784674 GO:0034061 DNA polymerase activity 2/918 35/18639 0.0571428571428571 1.16022408963585 0.519934044860024 0.899849944784674 GO:0043015 gamma-tubulin binding 2/918 35/18639 0.0571428571428571 1.16022408963585 0.519934044860024 0.899849944784674 GO:0061631 ubiquitin conjugating enzyme activity 2/918 35/18639 0.0571428571428571 1.16022408963585 0.519934044860024 0.899849944784674 GO:0003730 mRNA 3'-UTR binding 13/918 262/18639 0.049618320610687 1.0074464900464 0.529515758332195 0.902590058686839 GO:0000774 adenyl-nucleotide exchange factor activity 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0008252 nucleotidase activity 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0061578 K63-linked deubiquitinase activity 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0120283 protein serine/threonine kinase binding 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0140161 monocarboxylate:sodium symporter activity 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0140776 protein-containing complex destabilizing activity 1/918 15/18639 0.0666666666666667 1.35359477124183 0.531340468973704 0.902590058686839 GO:0004725 protein tyrosine phosphatase activity 5/918 98/18639 0.0510204081632653 1.0359143657463 0.532752845843165 0.902590058686839 GO:0042626 ATPase-coupled transmembrane transporter activity 5/918 98/18639 0.0510204081632653 1.0359143657463 0.532752845843165 0.902590058686839 GO:0000993 RNA polymerase II complex binding 2/918 36/18639 0.0555555555555556 1.12799564270152 0.535195539481554 0.903552539510014 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/918 36/18639 0.0555555555555556 1.12799564270152 0.535195539481554 0.903552539510014 GO:0030280 structural constituent of skin epidermis 2/918 37/18639 0.0540540540540541 1.09750927397986 0.550120139958213 0.918352905617577 GO:0043394 proteoglycan binding 2/918 37/18639 0.0540540540540541 1.09750927397986 0.550120139958213 0.918352905617577 GO:0046982 protein heterodimerization activity 18/918 369/18639 0.0487804878048781 0.990435198469632 0.551368353282999 0.918352905617577 GO:0000062 fatty-acyl-CoA binding 1/918 16/18639 0.0625 1.26899509803922 0.554441277042977 0.918352905617577 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/918 16/18639 0.0625 1.26899509803922 0.554441277042977 0.918352905617577 GO:0015378 sodium:chloride symporter activity 1/918 16/18639 0.0625 1.26899509803922 0.554441277042977 0.918352905617577 GO:0015562 efflux transmembrane transporter activity 1/918 16/18639 0.0625 1.26899509803922 0.554441277042977 0.918352905617577 GO:0017070 U6 snRNA binding 1/918 16/18639 0.0625 1.26899509803922 0.554441277042977 0.918352905617577 GO:0030275 LRR domain binding 1/918 16/18639 0.0625 1.26899509803922 0.554441277042977 0.918352905617577 GO:0034450 ubiquitin-ubiquitin ligase activity 1/918 16/18639 0.0625 1.26899509803922 0.554441277042977 0.918352905617577 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/918 16/18639 0.0625 1.26899509803922 0.554441277042977 0.918352905617577 GO:0016757 glycosyltransferase activity 13/918 267/18639 0.048689138576779 0.988580450906954 0.557358740304819 0.921601759269032 GO:0001786 phosphatidylserine binding 3/918 59/18639 0.0508474576271186 1.03240279162512 0.560999770183665 0.922873342076882 GO:0004879 nuclear receptor activity 3/918 59/18639 0.0508474576271186 1.03240279162512 0.560999770183665 0.922873342076882 GO:0045309 protein phosphorylated amino acid binding 3/918 59/18639 0.0508474576271186 1.03240279162512 0.560999770183665 0.922873342076882 GO:0043531 ADP binding 2/918 38/18639 0.0526315789473684 1.06862745098039 0.564703980867073 0.924764671988143 GO:0030971 receptor tyrosine kinase binding 4/918 81/18639 0.0493827160493827 1.00266279351247 0.569767707329238 0.924764671988143 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/918 60/18639 0.05 1.01519607843137 0.572506714717738 0.924764671988143 GO:0098531 ligand-modulated transcription factor activity 3/918 60/18639 0.05 1.01519607843137 0.572506714717738 0.924764671988143 GO:0008194 UDP-glycosyltransferase activity 7/918 145/18639 0.0482758620689655 0.980189317106153 0.576006270877795 0.924764671988143 GO:0004550 nucleoside diphosphate kinase activity 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:0016805 dipeptidase activity 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:0030548 acetylcholine receptor regulator activity 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:0045125 bioactive lipid receptor activity 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:0070403 NAD+ binding 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:1901567 fatty acid derivative binding 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:1990226 histone methyltransferase binding 1/918 17/18639 0.0588235294117647 1.19434832756632 0.57640459700617 0.924764671988143 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/918 39/18639 0.0512820512820513 1.0412267471091 0.578944393117476 0.924764671988143 GO:0015026 coreceptor activity 3/918 61/18639 0.0491803278688525 0.998553519768563 0.583824201549358 0.924764671988143 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/918 61/18639 0.0491803278688525 0.998553519768563 0.583824201549358 0.924764671988143 GO:0004177 aminopeptidase activity 2/918 40/18639 0.05 1.01519607843137 0.592839795719639 0.924764671988143 GO:0050997 quaternary ammonium group binding 2/918 40/18639 0.05 1.01519607843137 0.592839795719639 0.924764671988143 GO:0061791 GTPase motor activity 2/918 40/18639 0.05 1.01519607843137 0.592839795719639 0.924764671988143 GO:1990606 membrane scission GTPase motor activity 2/918 40/18639 0.05 1.01519607843137 0.592839795719639 0.924764671988143 GO:0000400 four-way junction DNA binding 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0008308 voltage-gated monoatomic anion channel activity 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0015280 ligand-gated sodium channel activity 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0015373 monoatomic anion:sodium symporter activity 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0017128 phospholipid scramblase activity 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0022851 GABA-gated chloride ion channel activity 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0031690 adrenergic receptor binding 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0034185 apolipoprotein binding 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0070064 proline-rich region binding 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0099602 neurotransmitter receptor regulator activity 1/918 18/18639 0.0555555555555556 1.12799564270152 0.597286380914898 0.924764671988143 GO:0003779 actin binding 21/918 443/18639 0.0474040632054176 0.962488381357057 0.60388052644768 0.924764671988143 GO:0042169 SH2 domain binding 2/918 41/18639 0.0487804878048781 0.990435198469632 0.606389595293316 0.924764671988143 GO:0042287 MHC protein binding 2/918 41/18639 0.0487804878048781 0.990435198469632 0.606389595293316 0.924764671988143 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/918 41/18639 0.0487804878048781 0.990435198469632 0.606389595293316 0.924764671988143 GO:0005125 cytokine activity 11/918 234/18639 0.047008547008547 0.954457851516675 0.606505057709095 0.924764671988143 GO:0004536 DNA nuclease activity 3/918 64/18639 0.046875 0.951746323529412 0.616610257005583 0.924764671988143 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0004890 GABA-A receptor activity 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0008301 DNA binding, bending 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0015245 fatty acid transmembrane transporter activity 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0031420 alkali metal ion binding 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0042577 lipid phosphatase activity 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0042800 histone H3K4 methyltransferase activity 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0097001 ceramide binding 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0120227 acyl-CoA binding 1/918 19/18639 0.0526315789473684 1.06862745098039 0.617139831444952 0.924764671988143 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/918 86/18639 0.0465116279069767 0.94436844505244 0.617406360786461 0.924764671988143 GO:0000510 H3-H4 histone complex chaperone activity 7/918 151/18639 0.0463576158940397 0.94124139722114 0.619017575316486 0.924764671988143 GO:0140584 chromatin extrusion motor activity 7/918 151/18639 0.0463576158940397 0.94124139722114 0.619017575316486 0.924764671988143 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 7/918 151/18639 0.0463576158940397 0.94124139722114 0.619017575316486 0.924764671988143 GO:0140849 ATP-dependent H2AZ histone chaperone activity 7/918 151/18639 0.0463576158940397 0.94124139722114 0.619017575316486 0.924764671988143 GO:0004520 DNA endonuclease activity 2/918 42/18639 0.0476190476190476 0.966853408029879 0.619594092817959 0.924764671988143 GO:0008307 structural constituent of muscle 2/918 42/18639 0.0476190476190476 0.966853408029879 0.619594092817959 0.924764671988143 GO:0043175 RNA polymerase core enzyme binding 2/918 42/18639 0.0476190476190476 0.966853408029879 0.619594092817959 0.924764671988143 GO:0004843 cysteine-type deubiquitinase activity 5/918 108/18639 0.0462962962962963 0.939996368917937 0.619692938029954 0.924764671988143 GO:0004175 endopeptidase activity 19/918 405/18639 0.0469135802469136 0.952529653836844 0.620093638857004 0.924764671988143 GO:0008236 serine-type peptidase activity 9/918 194/18639 0.0463917525773196 0.941934505761067 0.620695291722366 0.924764671988143 GO:0015616 DNA translocase activity 7/918 152/18639 0.0460526315789474 0.935049019607843 0.625950515514461 0.924764671988143 GO:0140674 ATP-dependent histone chaperone activity 7/918 152/18639 0.0460526315789474 0.935049019607843 0.625950515514461 0.924764671988143 GO:0120013 lipid transfer activity 3/918 65/18639 0.0461538461538462 0.93710407239819 0.627142528218094 0.924764671988143 GO:0008375 acetylglucosaminyltransferase activity 2/918 43/18639 0.0465116279069767 0.94436844505244 0.63245439715605 0.924764671988143 GO:0061775 cohesin loader activity 7/918 153/18639 0.0457516339869281 0.928937588107138 0.632812690508879 0.924764671988143 GO:0004721 phosphoprotein phosphatase activity 8/918 175/18639 0.0457142857142857 0.928179271708684 0.635799770880477 0.924764671988143 GO:0000339 RNA cap binding 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0001614 purinergic nucleotide receptor activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0001972 retinoic acid binding 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0010851 cyclase regulator activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0015095 magnesium ion transmembrane transporter activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0016408 C-acyltransferase activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0016502 nucleotide receptor activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0030742 GTP-dependent protein binding 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0061608 nuclear import signal receptor activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0140939 histone H4 methyltransferase activity 1/918 20/18639 0.05 1.01519607843137 0.636015536854916 0.924764671988143 GO:0016758 hexosyltransferase activity 9/918 197/18639 0.0456852791878173 0.92759032547029 0.638924685421108 0.92759547702703 GO:0004252 serine-type endopeptidase activity 8/918 176/18639 0.0454545454545455 0.922905525846702 0.642142026566578 0.929377190572537 GO:1902936 phosphatidylinositol bisphosphate binding 5/918 111/18639 0.045045045045045 0.914591061649885 0.643823222541988 0.929377190572537 GO:0017171 serine hydrolase activity 9/918 198/18639 0.0454545454545455 0.922905525846702 0.644893281063374 0.929377190572537 GO:0001223 transcription coactivator binding 2/918 44/18639 0.0454545454545455 0.922905525846702 0.644972344909779 0.929377190572537 GO:0019205 nucleobase-containing compound kinase activity 2/918 44/18639 0.0454545454545455 0.922905525846702 0.644972344909779 0.929377190572537 GO:0016500 protein-hormone receptor activity 3/918 67/18639 0.0447761194029851 0.909130816505707 0.647603128970975 0.931775248250776 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/918 21/18639 0.0476190476190476 0.966853408029879 0.653961599326971 0.933954047038815 GO:0005248 voltage-gated sodium channel activity 1/918 21/18639 0.0476190476190476 0.966853408029879 0.653961599326971 0.933954047038815 GO:0008373 sialyltransferase activity 1/918 21/18639 0.0476190476190476 0.966853408029879 0.653961599326971 0.933954047038815 GO:0009975 cyclase activity 1/918 21/18639 0.0476190476190476 0.966853408029879 0.653961599326971 0.933954047038815 GO:0015125 bile acid transmembrane transporter activity 1/918 21/18639 0.0476190476190476 0.966853408029879 0.653961599326971 0.933954047038815 GO:0046915 transition metal ion transmembrane transporter activity 2/918 45/18639 0.0444444444444444 0.90239651416122 0.657150426198047 0.9362756522834 GO:0030145 manganese ion binding 3/918 68/18639 0.0441176470588235 0.895761245674741 0.657529685265417 0.9362756522834 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/918 91/18639 0.043956043956044 0.892480068950657 0.661607265679085 0.937064585711375 GO:0140789 histone phosphatase activity 6/918 136/18639 0.0441176470588235 0.895761245674741 0.665913540548128 0.937064585711375 GO:0140658 ATP-dependent chromatin remodeler activity 7/918 158/18639 0.0443037974683544 0.899540828989824 0.666025446283658 0.937064585711375 GO:0008080 N-acetyltransferase activity 3/918 69/18639 0.0434782608695652 0.882779198635976 0.667253140456679 0.937064585711375 GO:0016887 ATP hydrolysis activity 19/918 417/18639 0.0455635491606715 0.925118728546575 0.67008944732383 0.937064585711375 GO:0008093 cytoskeletal anchor activity 1/918 22/18639 0.0454545454545455 0.922905525846702 0.671023757014039 0.937064585711375 GO:0015377 chloride:monoatomic cation symporter activity 1/918 22/18639 0.0454545454545455 0.922905525846702 0.671023757014039 0.937064585711375 GO:0033691 sialic acid binding 1/918 22/18639 0.0454545454545455 0.922905525846702 0.671023757014039 0.937064585711375 GO:0034062 5'-3' RNA polymerase activity 1/918 22/18639 0.0454545454545455 0.922905525846702 0.671023757014039 0.937064585711375 GO:0070034 telomerase RNA binding 1/918 22/18639 0.0454545454545455 0.922905525846702 0.671023757014039 0.937064585711375 GO:0097747 RNA polymerase activity 1/918 22/18639 0.0454545454545455 0.922905525846702 0.671023757014039 0.937064585711375 GO:0140784 metal ion sensor activity 1/918 22/18639 0.0454545454545455 0.922905525846702 0.671023757014039 0.937064585711375 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 8/918 181/18639 0.0441988950276243 0.897410898060882 0.67289444631475 0.937064585711375 GO:0051219 phosphoprotein binding 4/918 93/18639 0.043010752688172 0.873286949188278 0.678284841802672 0.937064585711375 GO:0008514 organic anion transmembrane transporter activity 12/918 269/18639 0.0446096654275093 0.90575114804286 0.678726917018305 0.937064585711375 GO:0003689 DNA clamp loader activity 7/918 160/18639 0.04375 0.888296568627451 0.678781584446866 0.937064585711375 GO:0140359 ABC-type transporter activity 2/918 47/18639 0.0425531914893617 0.863996662494785 0.68049981046341 0.937064585711375 GO:0042562 hormone binding 4/918 94/18639 0.0425531914893617 0.863996662494785 0.68640572885149 0.937064585711375 GO:0000295 adenine nucleotide transmembrane transporter activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0005283 amino acid:sodium symporter activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0016493 C-C chemokine receptor activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0016849 phosphorus-oxygen lyase activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0016917 GABA receptor activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0042171 lysophosphatidic acid acyltransferase activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0070577 lysine-acetylated histone binding 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0071617 lysophospholipid acyltransferase activity 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0099186 structural constituent of postsynapse 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:0140103 catalytic activity, acting on a glycoprotein 1/918 23/18639 0.0434782608695652 0.882779198635976 0.6872455001016 0.937064585711375 GO:1990782 protein tyrosine kinase binding 5/918 117/18639 0.0427350427350427 0.86768895592425 0.689116894193629 0.938289104523528 GO:0038187 pattern recognition receptor activity 2/918 48/18639 0.0416666666666667 0.845996732026144 0.691678768549363 0.940448988549487 GO:0005516 calmodulin binding 9/918 207/18639 0.0434782608695652 0.882779198635976 0.696042592722747 0.94504937941511 GO:0005315 phosphate transmembrane transporter activity 1/918 24/18639 0.0416666666666667 0.845996732026144 0.70266818117738 0.945657421501853 GO:0030552 cAMP binding 1/918 24/18639 0.0416666666666667 0.845996732026144 0.70266818117738 0.945657421501853 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/918 24/18639 0.0416666666666667 0.845996732026144 0.70266818117738 0.945657421501853 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/918 24/18639 0.0416666666666667 0.845996732026144 0.70266818117738 0.945657421501853 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/918 24/18639 0.0416666666666667 0.845996732026144 0.70266818117738 0.945657421501853 GO:0140033 acetylation-dependent protein binding 1/918 24/18639 0.0416666666666667 0.845996732026144 0.70266818117738 0.945657421501853 GO:0140713 histone chaperone activity 7/918 164/18639 0.0426829268292683 0.866630798660928 0.703357231552727 0.945657421501853 GO:0020037 heme binding 6/918 142/18639 0.0422535211267606 0.857912178956089 0.705907311044531 0.947402919912382 GO:0051015 actin filament binding 9/918 209/18639 0.0430622009569378 0.874331550802139 0.706756529938386 0.947402919912382 GO:0031491 nucleosome binding 3/918 74/18639 0.0405405405405405 0.823131955484897 0.712832082370752 0.947402919912382 GO:0015605 organophosphate ester transmembrane transporter activity 2/918 50/18639 0.04 0.812156862745098 0.71306750304668 0.947402919912382 GO:0003697 single-stranded DNA binding 5/918 121/18639 0.0413223140495868 0.839005023497002 0.717050005855378 0.947402919912382 GO:0000030 mannosyltransferase activity 1/918 25/18639 0.04 0.812156862745098 0.717331120187811 0.947402919912382 GO:0003707 nuclear steroid receptor activity 1/918 25/18639 0.04 0.812156862745098 0.717331120187811 0.947402919912382 GO:0004709 MAP kinase kinase kinase activity 1/918 25/18639 0.04 0.812156862745098 0.717331120187811 0.947402919912382 GO:0015271 outward rectifier potassium channel activity 1/918 25/18639 0.04 0.812156862745098 0.717331120187811 0.947402919912382 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/918 25/18639 0.04 0.812156862745098 0.717331120187811 0.947402919912382 GO:0047617 fatty acyl-CoA hydrolase activity 1/918 25/18639 0.04 0.812156862745098 0.717331120187811 0.947402919912382 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/918 25/18639 0.04 0.812156862745098 0.717331120187811 0.947402919912382 GO:0005249 voltage-gated potassium channel activity 4/918 98/18639 0.0408163265306122 0.828731492597039 0.717431671717882 0.947402919912382 GO:0019903 protein phosphatase binding 6/918 144/18639 0.0416666666666667 0.845996732026144 0.718491134356176 0.947504040382153 GO:0016830 carbon-carbon lyase activity 2/918 51/18639 0.0392156862745098 0.796232218377547 0.723287243274421 0.950061890692159 GO:0001637 G protein-coupled chemoattractant receptor activity 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0004950 chemokine receptor activity 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0005112 Notch binding 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0008157 protein phosphatase 1 binding 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0016289 acyl-CoA hydrolase activity 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0030507 spectrin binding 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0034237 protein kinase A regulatory subunit binding 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0043548 phosphatidylinositol 3-kinase binding 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0052742 phosphatidylinositol kinase activity 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0070006 metalloaminopeptidase activity 1/918 26/18639 0.0384615384615385 0.780920060331825 0.731271704246454 0.950061890692159 GO:0005267 potassium channel activity 5/918 124/18639 0.0403225806451613 0.81870651486401 0.73679916239463 0.955689168009296 GO:0051540 metal cluster binding 3/918 77/18639 0.038961038961039 0.791061879297173 0.737780621382226 0.955689168009296 GO:0005544 calcium-dependent phospholipid binding 2/918 53/18639 0.0377358490566038 0.766185719570847 0.742804471081581 0.955689168009296 GO:0008146 sulfotransferase activity 2/918 53/18639 0.0377358490566038 0.766185719570847 0.742804471081581 0.955689168009296 GO:0051018 protein kinase A binding 2/918 53/18639 0.0377358490566038 0.766185719570847 0.742804471081581 0.955689168009296 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/918 53/18639 0.0377358490566038 0.766185719570847 0.742804471081581 0.955689168009296 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/918 27/18639 0.037037037037037 0.75199709513435 0.744525482546661 0.955689168009296 GO:0005385 zinc ion transmembrane transporter activity 1/918 27/18639 0.037037037037037 0.75199709513435 0.744525482546661 0.955689168009296 GO:0015252 proton channel activity 1/918 27/18639 0.037037037037037 0.75199709513435 0.744525482546661 0.955689168009296 GO:0019199 transmembrane receptor protein kinase activity 3/918 78/18639 0.0384615384615385 0.780920060331825 0.745705633494766 0.955931157831057 GO:0050661 NADP binding 2/918 54/18639 0.037037037037037 0.75199709513435 0.7521134319718 0.957834266902997 GO:0016835 carbon-oxygen lyase activity 3/918 79/18639 0.0379746835443038 0.771034996276992 0.753438238909313 0.957834266902997 GO:0005242 inward rectifier potassium channel activity 1/918 28/18639 0.0357142857142857 0.725140056022409 0.757126256618344 0.957834266902997 GO:0046625 sphingolipid binding 1/918 28/18639 0.0357142857142857 0.725140056022409 0.757126256618344 0.957834266902997 GO:0046966 nuclear thyroid hormone receptor binding 1/918 28/18639 0.0357142857142857 0.725140056022409 0.757126256618344 0.957834266902997 GO:0051019 mitogen-activated protein kinase binding 1/918 28/18639 0.0357142857142857 0.725140056022409 0.757126256618344 0.957834266902997 GO:0051537 2 iron, 2 sulfur cluster binding 1/918 28/18639 0.0357142857142857 0.725140056022409 0.757126256618344 0.957834266902997 GO:0051959 dynein light intermediate chain binding 1/918 28/18639 0.0357142857142857 0.725140056022409 0.757126256618344 0.957834266902997 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/918 28/18639 0.0357142857142857 0.725140056022409 0.757126256618344 0.957834266902997 GO:0141052 histone H3 demethylase activity 1/918 28/18639 0.0357142857142857 0.725140056022409 0.757126256618344 0.957834266902997 GO:0008374 O-acyltransferase activity 2/918 55/18639 0.0363636363636364 0.738324420677362 0.761130565507509 0.961638093249329 GO:0046906 tetrapyrrole binding 6/918 152/18639 0.0394736842105263 0.801470588235294 0.765052521130466 0.965080583195771 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/918 29/18639 0.0344827586206897 0.700135226504395 0.769106166157024 0.965080583195771 GO:0005416 amino acid:monoatomic cation symporter activity 1/918 29/18639 0.0344827586206897 0.700135226504395 0.769106166157024 0.965080583195771 GO:0035250 UDP-galactosyltransferase activity 1/918 29/18639 0.0344827586206897 0.700135226504395 0.769106166157024 0.965080583195771 GO:0097472 cyclin-dependent protein kinase activity 1/918 29/18639 0.0344827586206897 0.700135226504395 0.769106166157024 0.965080583195771 GO:0030170 pyridoxal phosphate binding 2/918 56/18639 0.0357142857142857 0.725140056022409 0.769862000495381 0.965080583195771 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/918 130/18639 0.0384615384615385 0.780920060331825 0.773232166258733 0.968046504251193 GO:0005506 iron ion binding 6/918 154/18639 0.038961038961039 0.791061879297173 0.775754676813827 0.96892148411966 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/918 57/18639 0.0350877192982456 0.712418300653595 0.778313970446531 0.96892148411966 GO:0070279 vitamin B6 binding 2/918 57/18639 0.0350877192982456 0.712418300653595 0.778313970446531 0.96892148411966 GO:0032452 histone demethylase activity 1/918 30/18639 0.0333333333333333 0.676797385620915 0.780495770642131 0.96892148411966 GO:0051721 protein phosphatase 2A binding 1/918 30/18639 0.0333333333333333 0.676797385620915 0.780495770642131 0.96892148411966 GO:0098918 structural constituent of synapse 1/918 30/18639 0.0333333333333333 0.676797385620915 0.780495770642131 0.96892148411966 GO:0004386 helicase activity 6/918 155/18639 0.0387096774193548 0.78595825426945 0.78096679788483 0.96892148411966 GO:0005096 GTPase activator activity 11/918 271/18639 0.040590405904059 0.824144417914767 0.785529319737285 0.973070203927614 GO:0005184 neuropeptide hormone activity 1/918 31/18639 0.032258064516129 0.654965211891208 0.791324126950935 0.973070203927614 GO:0016411 acylglycerol O-acyltransferase activity 1/918 31/18639 0.032258064516129 0.654965211891208 0.791324126950935 0.973070203927614 GO:0017147 Wnt-protein binding 1/918 31/18639 0.032258064516129 0.654965211891208 0.791324126950935 0.973070203927614 GO:0047499 calcium-independent phospholipase A2 activity 1/918 31/18639 0.032258064516129 0.654965211891208 0.791324126950935 0.973070203927614 GO:0140457 protein demethylase activity 1/918 31/18639 0.032258064516129 0.654965211891208 0.791324126950935 0.973070203927614 GO:0015631 tubulin binding 16/918 385/18639 0.0415584415584416 0.843799337916985 0.791972955807951 0.973070203927614 GO:0016791 phosphatase activity 11/918 273/18639 0.0402930402930403 0.818106729871436 0.79325751784454 0.973070203927614 GO:0015459 potassium channel regulator activity 2/918 59/18639 0.0338983050847458 0.688268527750083 0.794404824160822 0.973070203927614 GO:0036002 pre-mRNA binding 2/918 59/18639 0.0338983050847458 0.688268527750083 0.794404824160822 0.973070203927614 GO:0004222 metalloendopeptidase activity 4/918 110/18639 0.0363636363636364 0.738324420677362 0.796771521497504 0.974730643050245 GO:0008378 galactosyltransferase activity 1/918 32/18639 0.03125 0.634497549019608 0.80161886316434 0.975395650948673 GO:0015106 bicarbonate transmembrane transporter activity 1/918 32/18639 0.03125 0.634497549019608 0.80161886316434 0.975395650948673 GO:0047498 calcium-dependent phospholipase A2 activity 1/918 32/18639 0.03125 0.634497549019608 0.80161886316434 0.975395650948673 GO:0160041 neuropeptide activity 1/918 32/18639 0.03125 0.634497549019608 0.80161886316434 0.975395650948673 GO:0050660 flavin adenine dinucleotide binding 3/918 86/18639 0.0348837209302326 0.70827633378933 0.802374223238898 0.975395650948673 GO:0015079 potassium ion transmembrane transporter activity 6/918 160/18639 0.0375 0.761397058823529 0.805658735730858 0.978154938595147 GO:0004197 cysteine-type endopeptidase activity 3/918 88/18639 0.0340909090909091 0.692179144385027 0.814765358894092 0.987967051539503 GO:0008234 cysteine-type peptidase activity 7/918 187/18639 0.0374331550802139 0.760039844814931 0.819885602906344 0.991435659024672 GO:0015020 glucuronosyltransferase activity 1/918 34/18639 0.0294117647058824 0.59717416378316 0.820711261308805 0.991435659024672 GO:0016831 carboxy-lyase activity 1/918 34/18639 0.0294117647058824 0.59717416378316 0.820711261308805 0.991435659024672 GO:0046943 carboxylic acid transmembrane transporter activity 7/918 188/18639 0.0372340425531915 0.755997079682937 0.824013788679003 0.991759721104451 GO:0035401 histone H3Y41 kinase activity 4/918 115/18639 0.0347826086956522 0.706223358908781 0.824065909340939 0.991759721104451 GO:0140801 histone H2AXY142 kinase activity 4/918 115/18639 0.0347826086956522 0.706223358908781 0.824065909340939 0.991759721104451 GO:0005342 organic acid transmembrane transporter activity 7/918 189/18639 0.037037037037037 0.75199709513435 0.828067523861485 0.993408167238364 GO:0015294 solute:monoatomic cation symporter activity 4/918 116/18639 0.0344827586206897 0.700135226504395 0.829145095682115 0.993408167238364 GO:0004623 phospholipase A2 activity 1/918 35/18639 0.0285714285714286 0.580112044817927 0.829557650027887 0.993408167238364 GO:0005343 organic acid:sodium symporter activity 1/918 35/18639 0.0285714285714286 0.580112044817927 0.829557650027887 0.993408167238364 GO:0019902 phosphatase binding 7/918 190/18639 0.0368421052631579 0.748039215686274 0.832047445729209 0.995153520698458 GO:0160215 deacylase activity 2/918 65/18639 0.0307692307692308 0.62473604826546 0.83663357845745 0.997285368130779 GO:0005484 SNAP receptor activity 1/918 36/18639 0.0277777777777778 0.563997821350762 0.837967996043497 0.997285368130779 GO:0016409 palmitoyltransferase activity 1/918 36/18639 0.0277777777777778 0.563997821350762 0.837967996043497 0.997285368130779 GO:0045505 dynein intermediate chain binding 1/918 36/18639 0.0277777777777778 0.563997821350762 0.837967996043497 0.997285368130779 GO:0019213 deacetylase activity 1/918 37/18639 0.027027027027027 0.548754636989931 0.845963769823643 0.999983174832655 GO:0022829 wide pore channel activity 1/918 37/18639 0.027027027027027 0.548754636989931 0.845963769823643 0.999983174832655 GO:0030551 cyclic nucleotide binding 1/918 37/18639 0.027027027027027 0.548754636989931 0.845963769823643 0.999983174832655 GO:0016410 N-acyltransferase activity 3/918 94/18639 0.0319148936170213 0.647997496871089 0.848044590298986 0.999983174832655 GO:0005109 frizzled binding 1/918 38/18639 0.0263157894736842 0.534313725490196 0.853565385741389 0.999983174832655 GO:0042162 telomeric DNA binding 1/918 38/18639 0.0263157894736842 0.534313725490196 0.853565385741389 0.999983174832655 GO:0042887 amide transmembrane transporter activity 1/918 38/18639 0.0263157894736842 0.534313725490196 0.853565385741389 0.999983174832655 GO:0016407 acetyltransferase activity 3/918 96/18639 0.03125 0.634497549019608 0.857921334736661 0.999983174832655 GO:0000217 DNA secondary structure binding 1/918 39/18639 0.0256410256410256 0.52061337355455 0.860792253968334 0.999983174832655 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/918 39/18639 0.0256410256410256 0.52061337355455 0.860792253968334 0.999983174832655 GO:0003823 antigen binding 6/918 174/18639 0.0344827586206897 0.700135226504395 0.863305397187575 0.999983174832655 GO:0016782 transferase activity, transferring sulphur-containing groups 2/918 70/18639 0.0285714285714286 0.580112044817927 0.865654105743228 0.999983174832655 GO:0008170 N-methyltransferase activity 3/918 98/18639 0.0306122448979592 0.621548619447779 0.867231322621242 0.999983174832655 GO:0004532 RNA exonuclease activity 1/918 40/18639 0.025 0.507598039215686 0.867662829820864 0.999983174832655 GO:0032451 demethylase activity 1/918 40/18639 0.025 0.507598039215686 0.867662829820864 0.999983174832655 GO:0016829 lyase activity 7/918 200/18639 0.035 0.710637254901961 0.867941007689481 0.999983174832655 GO:0001664 G protein-coupled receptor binding 11/918 297/18639 0.037037037037037 0.75199709513435 0.870647266257973 0.999983174832655 GO:0140299 molecular sensor activity 2/918 71/18639 0.028169014084507 0.571941452637393 0.870858838189915 0.999983174832655 GO:0001530 lipopolysaccharide binding 1/918 41/18639 0.024390243902439 0.495217599234816 0.874194660684053 0.999983174832655 GO:0001727 lipid kinase activity 1/918 41/18639 0.024390243902439 0.495217599234816 0.874194660684053 0.999983174832655 GO:0004812 aminoacyl-tRNA ligase activity 1/918 41/18639 0.024390243902439 0.495217599234816 0.874194660684053 0.999983174832655 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/918 41/18639 0.024390243902439 0.495217599234816 0.874194660684053 0.999983174832655 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/918 41/18639 0.024390243902439 0.495217599234816 0.874194660684053 0.999983174832655 GO:0043130 ubiquitin binding 3/918 100/18639 0.03 0.609117647058823 0.875999359734137 0.999983174832655 GO:0004519 endonuclease activity 4/918 127/18639 0.031496062992126 0.639493592712676 0.877351455777399 0.999983174832655 GO:0008017 microtubule binding 10/918 276/18639 0.036231884057971 0.735649332196647 0.878007246813974 0.999983174832655 GO:0048487 beta-tubulin binding 1/918 42/18639 0.0238095238095238 0.483426704014939 0.880404430632006 0.999983174832655 GO:0051879 Hsp90 protein binding 1/918 42/18639 0.0238095238095238 0.483426704014939 0.880404430632006 0.999983174832655 GO:0004521 RNA endonuclease activity 2/918 73/18639 0.0273972602739726 0.556271823798012 0.880715755476104 0.999983174832655 GO:0140375 immune receptor activity 5/918 156/18639 0.032051282051282 0.650766716943187 0.887888264514092 0.999983174832655 GO:0016790 thiolester hydrolase activity 1/918 44/18639 0.0227272727272727 0.461452762923351 0.891920460019202 0.999983174832655 GO:0043014 alpha-tubulin binding 1/918 44/18639 0.0227272727272727 0.461452762923351 0.891920460019202 0.999983174832655 GO:0051536 iron-sulfur cluster binding 2/918 76/18639 0.0263157894736842 0.534313725490196 0.894203317640282 0.999983174832655 GO:0140303 intramembrane lipid transporter activity 1/918 45/18639 0.0222222222222222 0.45119825708061 0.897256142606047 0.999983174832655 GO:0008094 ATP-dependent activity, acting on DNA 7/918 210/18639 0.0333333333333333 0.676797385620915 0.897278258091911 0.999983174832655 GO:0035091 phosphatidylinositol binding 10/918 284/18639 0.0352112676056338 0.714926815796741 0.897694567008079 0.999983174832655 GO:1901981 phosphatidylinositol phosphate binding 6/918 185/18639 0.0324324324324324 0.658505564387917 0.897985605527534 0.999983174832655 GO:0005543 phospholipid binding 19/918 497/18639 0.0382293762575453 0.776206257150748 0.8992307344363 0.999983174832655 GO:0030276 clathrin binding 1/918 46/18639 0.0217391304347826 0.441389599317988 0.902328685420269 0.999983174832655 GO:0140097 catalytic activity, acting on DNA 12/918 336/18639 0.0357142857142857 0.725140056022409 0.905734709223097 0.999983174832655 GO:0043495 protein-membrane adaptor activity 1/918 47/18639 0.0212765957446809 0.431998331247393 0.907151052267157 0.999983174832655 GO:0099095 ligand-gated monoatomic anion channel activity 1/918 47/18639 0.0212765957446809 0.431998331247393 0.907151052267157 0.999983174832655 GO:0140938 histone H3 methyltransferase activity 1/918 47/18639 0.0212765957446809 0.431998331247393 0.907151052267157 0.999983174832655 GO:0019787 ubiquitin-like protein transferase activity 18/918 479/18639 0.0375782881002088 0.762986614269925 0.908082951930549 0.999983174832655 GO:0015081 sodium ion transmembrane transporter activity 5/918 164/18639 0.0304878048780488 0.61902199904352 0.911245406300082 0.999983174832655 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/918 48/18639 0.0208333333333333 0.422998366013072 0.911735568942004 0.999983174832655 GO:0032266 phosphatidylinositol-3-phosphate binding 1/918 48/18639 0.0208333333333333 0.422998366013072 0.911735568942004 0.999983174832655 GO:0004713 protein tyrosine kinase activity 4/918 140/18639 0.0285714285714286 0.580112044817927 0.918734185095269 0.999983174832655 GO:0048020 CCR chemokine receptor binding 1/918 50/18639 0.02 0.406078431372549 0.920237351567371 0.999983174832655 GO:0030165 PDZ domain binding 2/918 83/18639 0.0240963855421687 0.489251122135601 0.920345944779389 0.999983174832655 GO:0004527 exonuclease activity 2/918 84/18639 0.0238095238095238 0.483426704014939 0.923542322055803 0.999983174832655 GO:0022843 voltage-gated monoatomic cation channel activity 4/918 143/18639 0.027972027972028 0.567941862059509 0.926300929955674 0.999983174832655 GO:0030159 signaling receptor complex adaptor activity 1/918 52/18639 0.0192307692307692 0.390460030165913 0.927921033487528 0.999983174832655 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/918 53/18639 0.0188679245283019 0.383092859785424 0.93148096737995 0.999983174832655 GO:0005244 voltage-gated monoatomic ion channel activity 5/918 173/18639 0.0289017341040462 0.58681854244588 0.932321145839767 0.999983174832655 GO:0016755 aminoacyltransferase activity 18/918 496/18639 0.0362903225806452 0.736835863377609 0.93291522262298 0.999983174832655 GO:0015293 symporter activity 4/918 146/18639 0.0273972602739726 0.556271823798012 0.933227372258268 0.999983174832655 GO:0140463 chromatin-protein adaptor activity 1/918 54/18639 0.0185185185185185 0.375998547567175 0.934865260500859 0.999983174832655 GO:0022832 voltage-gated channel activity 5/918 175/18639 0.0285714285714286 0.580112044817927 0.936349625934765 0.999983174832655 GO:0032182 ubiquitin-like protein binding 3/918 120/18639 0.025 0.507598039215686 0.939043162623814 0.999983174832655 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/918 56/18639 0.0178571428571429 0.362570028011204 0.94114112547053 0.999983174832655 GO:0008528 G protein-coupled peptide receptor activity 3/918 122/18639 0.0245901639344262 0.499276759884282 0.943358012431462 0.999983174832655 GO:0008408 3'-5' exonuclease activity 1/918 58/18639 0.0172413793103448 0.350067613252197 0.946812892972255 0.999983174832655 GO:0031593 polyubiquitin modification-dependent protein binding 1/918 59/18639 0.0169491525423729 0.344134263875042 0.94944061829659 0.999983174832655 GO:0051020 GTPase binding 10/918 315/18639 0.0317460317460317 0.644568938686586 0.950781704409611 0.999983174832655 GO:0016836 hydro-lyase activity 1/918 61/18639 0.0163934426229508 0.332851173256188 0.954313395601567 0.999983174832655 GO:0019905 syntaxin binding 1/918 61/18639 0.0163934426229508 0.332851173256188 0.954313395601567 0.999983174832655 GO:0001653 peptide receptor activity 3/918 128/18639 0.0234375 0.475873161764706 0.954659758381285 0.999983174832655 GO:0035591 signaling adaptor activity 3/918 129/18639 0.0232558139534884 0.47218422252622 0.956324894014161 0.999983174832655 GO:0015179 L-amino acid transmembrane transporter activity 1/918 62/18639 0.0161290322580645 0.327482605945604 0.956570920783921 0.999983174832655 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/918 130/18639 0.0230769230769231 0.468552036199095 0.957932643784831 0.999983174832655 GO:0022824 transmitter-gated monoatomic ion channel activity 1/918 63/18639 0.0158730158730159 0.322284469343293 0.958717009749866 0.999983174832655 GO:0022835 transmitter-gated channel activity 1/918 63/18639 0.0158730158730159 0.322284469343293 0.958717009749866 0.999983174832655 GO:1901682 sulfur compound transmembrane transporter activity 1/918 63/18639 0.0158730158730159 0.322284469343293 0.958717009749866 0.999983174832655 GO:0004842 ubiquitin-protein transferase activity 15/918 449/18639 0.0334075723830735 0.678304729464169 0.960111488866636 0.999983174832655 GO:0015171 amino acid transmembrane transporter activity 2/918 102/18639 0.0196078431372549 0.398116109188773 0.963961238417217 0.999983174832655 GO:0015103 inorganic anion transmembrane transporter activity 4/918 165/18639 0.0242424242424242 0.492216280451575 0.96498677101232 0.999983174832655 GO:0005253 monoatomic anion channel activity 2/918 103/18639 0.0194174757281553 0.394250904245193 0.965461680221794 0.999983174832655 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/918 67/18639 0.0149253731343284 0.303043605501902 0.96629292294995 0.999983174832655 GO:0042054 histone methyltransferase activity 1/918 67/18639 0.0149253731343284 0.303043605501902 0.96629292294995 0.999983174832655 GO:0016874 ligase activity 4/918 167/18639 0.0239520958083832 0.486321474697664 0.967349054315626 0.999983174832655 GO:0005548 phospholipid transporter activity 1/918 68/18639 0.0147058823529412 0.29858708189158 0.967959038431964 0.999983174832655 GO:0016279 protein-lysine N-methyltransferase activity 1/918 69/18639 0.0144927536231884 0.294259732878659 0.969542884359456 0.999983174832655 GO:0098960 postsynaptic neurotransmitter receptor activity 1/918 69/18639 0.0144927536231884 0.294259732878659 0.969542884359456 0.999983174832655 GO:0000149 SNARE binding 2/918 106/18639 0.0188679245283019 0.383092859785424 0.969611053093133 0.999983174832655 GO:0004497 monooxygenase activity 2/918 106/18639 0.0188679245283019 0.383092859785424 0.969611053093133 0.999983174832655 GO:0016278 lysine N-methyltransferase activity 1/918 70/18639 0.0142857142857143 0.290056022408964 0.971048518832155 0.999983174832655 GO:0031267 small GTPase binding 8/918 283/18639 0.0282685512367491 0.573962447169681 0.971215188360393 0.999983174832655 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 6/918 229/18639 0.0262008733624454 0.531980477780632 0.971912869890043 0.999983174832655 GO:0042379 chemokine receptor binding 1/918 72/18639 0.0138888888888889 0.281998910675381 0.973840395827278 0.999983174832655 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/918 73/18639 0.0136986301369863 0.278135911899006 0.975133793609933 0.999983174832655 GO:0003684 damaged DNA binding 1/918 74/18639 0.0135135135135135 0.274377318494966 0.976363308716368 0.999983174832655 GO:0061659 ubiquitin-like protein ligase activity 11/918 372/18639 0.0295698924731183 0.600384777566941 0.977748167298208 0.999983174832655 GO:0046873 metal ion transmembrane transporter activity 14/918 450/18639 0.0311111111111111 0.631677559912854 0.978071464979344 0.999983174832655 GO:0017022 myosin binding 1/918 76/18639 0.0131578947368421 0.267156862745098 0.978643143467642 0.999983174832655 GO:0004518 nuclease activity 5/918 209/18639 0.0239234449760766 0.485739750445633 0.978777517740423 0.999983174832655 GO:0017124 SH3 domain binding 2/918 115/18639 0.0173913043478261 0.35311167945439 0.979372585547299 0.999983174832655 GO:0008509 monoatomic anion transmembrane transporter activity 3/918 149/18639 0.0201342281879195 0.408803789972365 0.979692479473812 0.999983174832655 GO:0015370 solute:sodium symporter activity 1/918 79/18639 0.0126582278481013 0.257011665425664 0.981657683947453 0.999983174832655 GO:0061630 ubiquitin protein ligase activity 10/918 353/18639 0.028328611898017 0.575181914125424 0.981758529725414 0.999983174832655 GO:0015101 organic cation transmembrane transporter activity 1/918 81/18639 0.0123456790123457 0.250665698378117 0.983427323748276 0.999983174832655 GO:0004540 RNA nuclease activity 2/918 121/18639 0.0165289256198347 0.335602009398801 0.98411057866245 0.999983174832655 GO:0015108 chloride transmembrane transporter activity 2/918 121/18639 0.0165289256198347 0.335602009398801 0.98411057866245 0.999983174832655 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/918 122/18639 0.0163934426229508 0.332851173256188 0.984789788099633 0.999983174832655 GO:0005254 chloride channel activity 1/918 83/18639 0.0120481927710843 0.244625561067801 0.985026399240818 0.999983174832655 GO:0005261 monoatomic cation channel activity 9/918 341/18639 0.0263929618768328 0.535880627910988 0.988124701511461 0.999983174832655 GO:0015291 secondary active transmembrane transporter activity 7/918 287/18639 0.024390243902439 0.495217599234816 0.98893526246804 0.999983174832655 GO:0022836 gated channel activity 8/918 318/18639 0.0251572327044025 0.510790479713898 0.989759295814617 0.999983174832655 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 3/918 167/18639 0.0179640718562874 0.364741106023248 0.990053589511598 0.999983174832655 GO:0099094 ligand-gated monoatomic cation channel activity 2/918 136/18639 0.0147058823529412 0.29858708189158 0.991792050830498 0.999983174832655 GO:0008276 protein methyltransferase activity 1/918 95/18639 0.0105263157894737 0.213725490196078 0.991856229771875 0.999983174832655 GO:0030594 neurotransmitter receptor activity 1/918 97/18639 0.0103092783505155 0.209318779058015 0.992642589524935 0.999983174832655 GO:0140767 enzyme-substrate adaptor activity 2/918 139/18639 0.0143884892086331 0.292142756383129 0.992816868379795 0.999983174832655 GO:0042393 histone binding 5/918 247/18639 0.0202429149797571 0.411010558069382 0.994382350466009 0.999983174832655 GO:0015085 calcium ion transmembrane transporter activity 2/918 147/18639 0.0136054421768707 0.27624383086568 0.994975909995162 0.999983174832655 GO:0015276 ligand-gated monoatomic ion channel activity 3/918 186/18639 0.0161290322580645 0.327482605945604 0.99541363483308 0.999983174832655 GO:0022834 ligand-gated channel activity 3/918 188/18639 0.0159574468085106 0.323998748435544 0.99577714204423 0.999983174832655 GO:0003774 cytoskeletal motor activity 2/918 153/18639 0.0130718954248366 0.265410739459182 0.996163825285943 0.999983174832655 GO:0140098 catalytic activity, acting on RNA 9/918 387/18639 0.0232558139534884 0.47218422252622 0.997084750347435 0.999983174832655 GO:0005216 monoatomic ion channel activity 11/918 448/18639 0.0245535714285714 0.498533788515406 0.997384951464525 0.999983174832655 GO:0008168 methyltransferase activity 3/918 204/18639 0.0147058823529412 0.29858708189158 0.997833265333729 0.999983174832655 GO:0004674 protein serine/threonine kinase activity 10/918 433/18639 0.023094688221709 0.468912738305484 0.998288835979796 0.999983174832655 GO:0140030 modification-dependent protein binding 2/918 173/18639 0.0115606936416185 0.234727416978352 0.998453199553114 0.999983174832655 GO:0016741 transferase activity, transferring one-carbon groups 3/918 215/18639 0.013953488372093 0.283310533515732 0.998639163639996 0.999983174832655 GO:0005262 calcium channel activity 1/918 131/18639 0.00763358778625954 0.154991767699446 0.99869302114512 0.999983174832655 GO:0140101 catalytic activity, acting on a tRNA 1/918 139/18639 0.00719424460431655 0.146071378191564 0.999130068510672 0.999983174832655 GO:0141003 histone H2AX kinase activity 6/918 354/18639 0.0169491525423729 0.344134263875042 0.999645035679444 0.999983174832655 GO:0035402 histone H3T11 kinase activity 3/918 247/18639 0.0121457489878543 0.246606334841629 0.999657087154377 0.999983174832655 GO:0140996 histone H3 kinase activity 6/918 357/18639 0.0168067226890756 0.341242379304663 0.999683268632839 0.999983174832655 GO:0035173 histone kinase activity 6/918 360/18639 0.0166666666666667 0.338398692810457 0.999717477950733 0.999983174832655 GO:0106310 protein serine kinase activity 6/918 361/18639 0.0166204986149584 0.337461300309598 0.99972805929982 0.999983174832655 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 2/918 243/18639 0.00823045267489712 0.167110465585411 0.999940730666615 0.999983174832655 GO:0004676 3-phosphoinositide-dependent protein kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0004711 ribosomal protein S6 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0035175 histone H3S10 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0035979 histone H2AXS139 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0044022 histone H3S28 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0044023 histone H4S1 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0044024 histone H2AS1 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0044025 histone H2BS14 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0072354 histone H3T3 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0072371 histone H2AS121 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0072518 Rho-dependent protein serine/threonine kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0140823 histone H2BS36 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0140855 histone H3S57 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0140995 histone H2A kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0140997 histone H4 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0140998 histone H2B kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:1990244 histone H2AT120 kinase activity 2/918 245/18639 0.00816326530612245 0.165746298519408 0.99994608449058 0.999983174832655 GO:0004677 DNA-dependent protein kinase activity 2/918 246/18639 0.00813008130081301 0.165072533078272 0.9999485785472 0.999983174832655 GO:0140857 histone H3T45 kinase activity 2/918 246/18639 0.00813008130081301 0.165072533078272 0.9999485785472 0.999983174832655 GO:0035403 histone H3T6 kinase activity 2/918 247/18639 0.00809716599190283 0.164404223227753 0.999950958068774 0.999983174832655 GO:0004679 AMP-activated protein kinase activity 2/918 248/18639 0.00806451612903226 0.163741302972802 0.999953228271133 0.999983174832655 GO:0045182 translation regulator activity 4/918 356/18639 0.0112359550561798 0.228133950209297 0.999983174832655 0.999983174832655