category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	69/278	238/9376	9.77788525482135	RPL23A/RPS2/RPS4X/NFKBIA/RPS13/RPL28/RPS18/RPS3A/RPS26/RPL9/RPS6/RPL14/RPS7/RPS23/RPL13/RPS15/RPL10/RPS9/RPL7/RPS3/RPL27A/RPL3/RPS12/RPL30/RPL7A/RPL10A/RPL12/RPL18/RPL11/RPL15/RPS5/RPS8/RPS27A/RPL24/RPL19/FAU/RPS19/RPL18A/RPL32/RPL17/RPL5/RPS15A/RPL27/RPL37A/RPL26/RPL36/RPL21/RPL23/UBA52/JUN/RPLP1/RPS24/RPL35A/RPL39/RPS20/RPS25/RPSA/RPLP0/RPL29/RPL8/RPL35/RPS11/RPS14/RPS16/RPL31/FOS/RPL4/C1R/RPLP2	23.9766150698615
Genetic Information Processing	Translation	hsa03010	Ribosome	65/278	222/9376	9.87491088210513	RPL23A/RPS2/RPS4X/RPS13/RPL28/RPS18/RPS3A/RPS26/RPL9/RPS6/RPL14/RPS7/RPS23/RPL13/RPS15/RPL10/RPS9/RPL7/RPS3/RPL27A/RPL3/RPS12/RPL30/RPL7A/RPL10A/RPL12/RPL18/RPL11/RPL15/RPS5/RPS8/RPS27A/RPL24/RPL19/FAU/RPS19/RPL18A/RPL32/RPL17/RPL5/RPS15A/RPL27/RPL37A/RPL26/RPL36/RPL21/RPL23/UBA52/RPLP1/RPS24/RPL35A/RPL39/RPS20/RPS25/RPSA/RPLP0/RPL29/RPL8/RPL35/RPS11/RPS14/RPS16/RPL31/RPL4/RPLP2	23.39214804422
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	17/278	157/9376	3.65192686615039	HLA-B/HLA-C/FOXO1/ZFP36L2/FOXO3/TGFBR2/RHEB/GADD45G/HLA-E/ZFP36L1/GADD45B/SERPINE1/CDKN2A/VDAC2/MYC/EIF4EBP1/HLA-A	5.85739526386742
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/278	268/9376	2.64275743584237	PSMD8/TUBA1B/MT-ND1/MT-CO3/DUSP1/RPS27A/SLC39A4/TUBA1C/MT-CO1/MT-ATP6/UBA52/UBC/NDUFA4L2/NDUFS5/TUBA1A/TUBB2A/VDAC2/MAOA/TXN/CYCS/MT-ND2	4.76940714115165
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	19/278	248/9376	2.58389417498259	NFKBIA/ANXA2/TUBA1B/RPS3/RHOB/TUBA1C/JUN/MYL12B/TUBA1A/HSP90B1/TUBB2A/FOS/ARPC3/ARPC2/GAPDH/ELMO1/MYC/TXN/CYCS	4.41874822050682
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	16/278	205/9376	2.63232145990525	NFKBIA/HLA-B/HLA-C/PSMD8/B2M/PDIA3/JUN/CD44/GADD45G/HLA-E/GADD45B/MYC/HLA-A/TNFAIP3/RBPJ/CYCS	4.1305638893969
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	14/278	174/9376	2.71363598776151	PDIA3/UBXN4/CRYAB/OSTC/KRTCAP2/PDIA6/RRBP1/SEC61G/HSP90B1/SEC61B/LMAN2/CKAP4/LMAN1/HSPA8	3.98829389493082
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/278	155/9376	2.82868414945463	HLA-B/HLA-C/TUBA1B/TUBA1C/CD36/HLA-E/SEC61G/TUBA1A/SEC61B/TUBB2A/C1R/HLA-A/ATP6V1G1	4.01282858559009
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/278	110/9376	3.06605624591236	RPS6/LDHA/EGLN3/TIMP1/SERPINE1/PDHA1/PGK1/GAPDH/EIF4EBP1/FLT1	3.81002131259753
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/278	196/9376	2.40904419321685	NFKBIA/HLA-B/HLA-C/RPS27A/UBA52/JUN/ZFP36/UBC/RCAN1/HLA-E/FOS/MYC/HLA-A/CYCS	3.48470789665489
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/278	200/9376	2.36086330935252	NFKBIA/TUBA1B/RPS3/TUBA1C/JUN/TUBA1A/TUBB2A/FOS/ARPC3/BAIAP2/ARPC2/GAPDH/CYCS/CLDN1	3.40046156463943
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	15/278	224/9376	2.2584789311408	NFKBIA/HLA-B/HLA-C/EGR1/B2M/JUN/ZFP36/TGFBR2/HLA-E/FOS/CDKN2A/VDAC2/MYC/ETS2/HLA-A	3.33232247729769
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	14/278	205/9376	2.30328127741709	PDK4/MT-ND1/MT-CO3/MT-CO1/MT-ATP6/COL1A1/CD36/TGFBR2/NDUFA4L2/NDUFS5/PDHA1/GAPDH/VDAC2/MT-ND2	3.29793286093206
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	17/278	275/9376	2.08491824722041	PSMD8/TUBA1B/MT-ND1/EGR1/MT-CO3/TUBA1C/MT-CO1/MT-ATP6/PRNP/NDUFA4L2/NDUFS5/TUBA1A/TUBB2A/VDAC2/CYCS/MT-ND2/HSPA8	3.19193378305012
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	24/278	480/9376	1.6863309352518	DKK1/PSMD8/TUBA1B/MT-ND1/MT-CO3/RPS27A/TUBA1C/MT-CO1/MT-ATP6/UBA52/UBC/PRNP/FZD4/FUS/NDUFA4L2/NDUFS5/GPX8/TUBA1A/HSD17B10/TUBB2A/VDAC2/BDNF/CYCS/MT-ND2	2.69831020539008
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/278	82/9376	2.87910159677136	HLA-B/HLA-C/B2M/PDIA3/HLA-E/HLA-A/HSPA8	2.98738312625988
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	20/278	388/9376	1.73848550025959	DKK1/PSMD8/TUBA1B/MT-ND1/MT-CO3/SLC39A4/TUBA1C/MT-CO1/MT-ATP6/APOE/FZD4/NDUFA4L2/NDUFS5/TUBA1A/HSD17B10/TUBB2A/GAPDH/VDAC2/CYCS/MT-ND2	2.59693675715116
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/278	87/9376	2.71363598776151	JUN/TGFBR2/GADD45G/GADD45B/FOS/MYC/CYCS	2.80691194636837
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/278	49/9376	3.44149170459551	JUN/FOSB/PPP1R1B/MAOA/BDNF	2.99514170629855
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/278	227/9376	1.9314803663677	NFKBIA/MT-ND1/MT-CO3/GSTM3/MT-CO1/MT-ATP6/JUN/FOXO3/NDUFA4L2/NDUFS5/FOS/VDAC2/MT-ND2	2.48333260144018
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/278	180/9376	2.06107114308553	NFKBIA/HLA-B/HLA-C/B2M/PDIA3/SRSF5/RHEB/HLA-E/EIF4EBP1/HLA-A/CYCS	2.51255944032999
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	14/278	253/9376	1.86629510620752	NFKBIA/FOXO1/RPS27A/UBA52/JUN/FOXO3/CD44/UBC/MYL12B/ARPC3/ARPC2/BNIP3/ELMO1/CYCS	2.4417002861577
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/278	137/9376	2.21561728719214	NFKBIA/TUBA1B/TUBA1C/JUN/GADD45G/TUBA1A/GADD45B/FOS/CYCS	2.50541537049745
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	16/278	308/9376	1.75203214052135	PSMD8/TUBA1B/MT-ND1/MT-CO3/TUBA1C/MT-CO1/MT-ATP6/NDUFA4L2/NDUFS5/GPX8/TUBA1A/TUBB2A/VDAC2/BDNF/CYCS/MT-ND2	2.34580049936649
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/278	94/9376	2.51155671207715	NFKBIA/JUN/FOSB/CEBPB/HSP90B1/FOS/TNFAIP3	2.57455788534472
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/278	138/9376	2.19956208945887	MT-ND1/MT-CO3/MT-CO1/MT-ATP6/NDUFA4L2/NDUFS5/CYCS/ATP6V1G1/MT-ND2	2.48146621207425
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/278	75/9376	2.69812949640288	GADD45G/GADD45B/SERPINE1/STEAP3/CDKN2A/CYCS	2.58090301601975
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/278	56/9376	3.01130524152107	NFKBIA/EEF1A1/BNIP3/CYCS/HSPA8	2.6387552636705
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/278	77/9376	2.62804821078202	NFKBIA/TGFBR2/GADD45G/GADD45B/CDKN2A/MYC	2.50743434367164
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/278	39/9376	3.45914038000369	HLA-B/HLA-C/HLA-E/HLA-A	2.68996739003271
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/278	59/9376	2.85818802585051	PRDX6/GSTM3/GGT5/GPX8/ODC1	2.50272242576163
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/278	42/9376	3.21205892428914	FTH1/PRNP/STEAP3/VDAC2	2.51143827223468
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/278	201/9376	1.84573535201689	FOXO1/ZBTB16/ZEB1/CEBPB/FUS/TGFBR2/GADD45G/NFKBIZ/GADD45B/MYC/FLT1	2.11867599892923
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	12/278	227/9376	1.78290495357018	NFKBIA/HLA-B/HLA-C/B2M/PDIA3/RHEB/HLA-E/CDKN2A/MYC/EIF4EBP1/HLA-A/CYCS	2.08722960271433
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/278	44/9376	3.06605624591236	HLA-B/HLA-C/HLA-E/HLA-A	2.40113281792254
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/278	45/9376	2.99792166266986	HLA-B/HLA-C/HLA-E/HLA-A	2.34831140791632
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/278	88/9376	2.29954218443427	CLU/F10/SERPINF2/SERPINE1/C1R/CD59	2.1409458564327
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	17/278	368/9376	1.55802314670003	PSMD8/TUBA1B/MT-ND1/MT-CO3/TUBA1C/MT-CO1/MT-ATP6/HNRNPA1/HNRNPA2B1/FUS/NDUFA4L2/NDUFS5/GPX8/TUBA1A/TUBB2A/CYCS/MT-ND2	1.90896077318458
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/278	67/9376	2.5169118436594	LDHA/PDHA1/PGK1/TPI1/GAPDH	2.17811746971245
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/278	69/9376	2.44395787717652	JUN/FOSB/FOS/PPP1R1B/MAOA	2.10430788536926
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/278	70/9376	2.40904419321685	HLA-B/HLA-C/HLA-E/HLA-A/CYCS	2.06836500060686
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/278	93/9376	2.17591088419587	NFKBIA/LAMB1/GADD45G/GADD45B/MYC/CYCS	1.99208001780486
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/278	50/9376	2.69812949640288	CKB/OAT/ODC1/MAOA	2.10447209884892
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/278	51/9376	2.64522499647341	KDELR2/SEC61G/SEC61B/ATP6V1G1	2.05930672138633
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/278	52/9376	2.59435528500277	APOE/CD36/VDAC2/ANGPTL4	2.01521188134908
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/278	99/9376	2.04403749727491	JUN/RHEB/PLPP3/FOS/EIF4EBP1/CHPT1	1.825429168455
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/278	54/9376	2.49826805222489	HLA-B/HLA-C/HLA-E/HLA-A	1.93004270993632
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/278	101/9376	2.00356150722986	EGR1/FOXO1/JUN/COL1A1/TGFBR2/SERPINE1	1.77248591495498
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/278	16/9376	4.2158273381295	MIF/MAOA	2.25034891171351
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/278	205/9376	1.64520091244078	NFKBIA/HLA-B/HLA-C/JUN/HLA-E/GTF2B/CDKN2A/HLA-A/YWHAQ/RBPJ	1.63267080400237
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/278	17/9376	3.96783749471011	GLUL/CA8	2.14084351765569
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/278	105/9376	1.92723535457348	RPS27A/UBA52/JUN/FOXO3/UBC/BNIP3	1.6701535900061
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/278	37/9376	2.73459070581373	PNMT/MIF/MAOA	1.84791827010119
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/278	37/9376	2.73459070581373	UGP2/UAP1/PGM3	1.84791827010119
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/278	37/9376	2.73459070581373	GADD45G/GADD45B/MYC	1.84791827010119
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/278	59/9376	2.2865504206804	FOXO3/GADD45G/GADD45B/MYC	1.73280558528846
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/278	38/9376	2.66262779250284	UGP2/UAP1/PGM3	1.79512613301745
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	10/278	214/9376	1.57601021986149	NFKBIA/HLA-B/HLA-C/B2M/PDIA3/JUN/HLA-E/FOS/HLA-A/CYCS	1.48996820806213
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/278	61/9376	2.21158155442859	FTH1/ATP1B1/SLC39A4/MT1A	1.65943868676114
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/278	62/9376	2.17591088419587	FOXO1/CRYAB/FOXO3/HSPA8	1.62381746465544
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/278	138/9376	1.71077051402356	NFKBIA/JUN/FOS/ARPC3/BAIAP2/ARPC2/ELMO1	1.47033074034856
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/278	63/9376	2.14137261619276	BMP2/FZD4/GADD45G/GADD45B	1.58886863484312
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/278	20/9376	3.3726618705036	UGP2/UAP1	1.85669604465416
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/278	139/9376	1.69846281248383	FKBP5/JUN/HSP90B1/FOS/KRT10/KRT19/HSPA8	1.4501745748873
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	11/278	250/9376	1.48397122302158	HLA-B/HLA-C/ARF4/TGFBR2/ARF5/HLA-E/ARPC3/ARPC2/HLA-A/PSD4/HSPA8	1.355764884926
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/278	142/9376	1.66257979531867	GSTM3/DUSP1/JUN/GPC1/HSP90B1/FOS/TXN	1.39066490662011
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	8/278	170/9376	1.58713499788405	TUBA1B/TUBA1C/JUN/MYL12B/TUBA1A/ARPC3/ARPC2/CLDN1	1.35039870826324
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/278	91/9376	1.85311091785912	NFKBIA/JUN/IFITM1/FOS/CD81	1.42945442040532
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/278	119/9376	1.70050178344719	NFKBIA/JUN/CEBPB/JUNB/FOS/TNFAIP3	1.34425810621354
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/278	93/9376	1.81325907016322	SNAI2/SSX2IP/MYL12B/TGFBR2/BAIAP2	1.37772102014226
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/278	120/9376	1.6863309352518	NFKBIA/JUN/FOXO3/IRAK3/MAGED1/BDNF	1.32265809544799
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/278	122/9376	1.65868616582144	FOXO1/ATP1B1/RCAN1/RHEB/MYC/SLC16A10	1.28005544068936
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/278	233/9376	1.447494365023	VCAN/ATP1B1/PDLIM1/COL1A1/TNNT3/NEBL/FBN1/TRIM63/ELN/ACTC1	1.2090833522928
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/278	71/9376	1.90009119464991	LDHA/SLC16A3/PDHA1/MYC	1.33073803090121
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/278	47/9376	2.15276289606613	LDHA/PDHA1/ACYP1	1.38486181878938
NA	NA	hsa03272	Virion - Hepatitis viruses	3/278	48/9376	2.10791366906475	CD63/CD81/CLDN1	1.34513954505378
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/278	73/9376	1.84803390164581	FOXO3/GADD45G/GADD45B/CDKN2A	1.27144683127437
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/278	75/9376	1.79875299760192	GLUL/PGK1/TPI1/GAPDH	1.21398516716921
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/278	157/9376	1.50373459194428	BMP2/SNAI2/FZD4/TGFBR2/SERPINE1/MYC/YWHAQ	1.11261462401629
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/278	157/9376	1.50373459194428	MT-CO3/MT-CO1/JUN/NDUFA4L2/NDUFS5/FOS/CYCS	1.11261462401629
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/278	362/9376	1.30434436980802	RPS6/DDIT4/LAMB1/FOXO3/COL1A1/RHEB/HSP90B1/CSH1/MYC/EIF4EBP1/BDNF/YWHAQ/FLT1/PGF	1.0322760475262
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/278	76/9376	1.77508519500189	UBC/CD36/PLIN2/ANGPTL4	1.18590481731073
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/278	103/9376	1.63721450024446	ATP1B1/SLC38A2/COL1A1/ELN/SLC16A10	1.13665640178573
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/278	103/9376	1.63721450024446	NFKBIA/JUN/TGFBR2/FOS/SERPINE1	1.13665640178573
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/278	77/9376	1.75203214052135	TGFBR2/GADD45G/GADD45B/CDKN2A	1.15824040357033
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/278	160/9376	1.47553956834532	HLA-B/HLA-C/VCAN/HLA-E/CDH15/HLA-A/CLDN1	1.06049954722288
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/278	78/9376	1.72957019000184	NFKBIA/EEF1A1/JUN/FOS	1.13097936421856
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/278	133/9376	1.52150159571591	FOXO1/FOXO3/TGFBR2/GADD45G/GADD45B/BNIP3	1.05879054773147
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/278	163/9376	1.44838239837578	NFKBIA/JUN/TGFBR2/FOS/MYC/YWHAQ/CYCS	1.00943159095799
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/278	136/9376	1.48793906051629	NFKBIA/JUN/FOS/TNFAIP3/CYCS/HSPA8	1.00192248744588
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/278	138/9376	1.46637472630591	RPS6/FOXO1/PRKAR2B/RHEB/PDE3B/EIF4EBP1	0.964763004485712
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/278	31/9376	2.17591088419587	SEC61G/SEC61B	1.14630628657706
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/278	170/9376	1.38874312314854	GSTM3/FZD4/TGFBR2/GADD45G/GADD45B/CDKN2A/MYC	0.894101379134074
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/278	142/9376	1.42506839598744	NFKBIA/JUN/FOSB/JUNB/TGFBR2/FOS	0.892160771260341
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/278	87/9376	1.55064913586372	MT-CO3/ATP1B1/MT-CO1/ACTC1	0.901955636291415
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/278	10/9376	3.3726618705036	ETHE1	1.31218129982815
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/278	235/9376	1.29165773763968	RPS6/MT-ND1/MT-CO3/MT-CO1/MT-ATP6/RHEB/NDUFA4L2/NDUFS5/MT-ND2	0.791490395631455
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/278	89/9376	1.51580308786679	LAMB1/CD44/COL1A1/CD36	0.854626368197101
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/278	89/9376	1.51580308786679	TUBA1B/TUBA1C/TUBA1A/TUBB2A	0.854626368197101
NA	NA	hsa04517	IgSF CAM signaling	11/278	299/9376	1.24077861456654	TUBA1B/FOXO1/TUBA1C/SSX2IP/MYL12B/TUBA1A/TUBB2A/ARPC3/BAIAP2/ARPC2/PLXNA4	0.739634920794257
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/278	148/9376	1.36729535290686	JUN/FZD4/GADD45G/GADD45B/FOS/MYC	0.787277007989681
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/278	300/9376	1.23664268585132	DUSP1/JUN/TGFBR2/GADD45G/GADD45B/FOS/MYC/BDNF/FLT1/PGF/HSPA8	0.728184682970027
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/278	90/9376	1.49896083133493	FOXO1/FOXO3/RHEB/EIF4EBP1	0.831396974215177
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	12/278	333/9376	1.21537364702832	HLA-B/HLA-C/FOXO1/LAMB1/COL1A1/FZD4/RHEB/HLA-E/EIF4EBP1/HLA-A/RBPJ/ATP6V1G1	0.699509284950279
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/278	36/9376	1.87370103916867	DCXR/UGP2	0.918069869699541
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/278	122/9376	1.38223847151787	FOXO1/FOXO3/CD36/RHEB/EIF4EBP1	0.742821787515525
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/278	93/9376	1.45060725613058	NFKBIA/JUN/FOS/RBPJ	0.76336202247966
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/278	65/9376	1.55661317100166	KCNK3/HSD3B2/CYP11A1	0.787131084910704
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/278	95/9376	1.42006815600151	JUN/FOS/FLT1/ATP6V1G1	0.719315214891656
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/278	66/9376	1.53302812295618	HSD11B1/HSD3B2/CYP11A1	0.759595390330579
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/278	155/9376	1.30554653051752	KCNK3/HSD3B2/RASD1/FZD4/CYP11A1/CDKN2A	0.670485306199131
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/278	156/9376	1.29717764250138	NFKBIA/MYC/YWHAQ/CD81/CYCS/CLDN1	0.654256493488085
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/278	158/9376	1.28075767234314	RPS6/DDIT4/FZD4/RHEB/EIF4EBP1/ATP6V1G1	0.622123912628953
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/278	68/9376	1.48793906051629	ZBTB16/MYC/EIF4EBP1	0.705873576003022
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/278	98/9376	1.3765966818382	ATP1B1/KCNK3/HSD3B2/CYP11A1	0.655084634473604
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/278	130/9376	1.29717764250138	NFKBIA/JUN/COL1A1/TGFBR2/FOS	0.59641139800566
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/278	41/9376	1.64520091244078	CDKN2A/MYC	0.723710393955516
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/278	71/9376	1.42506839598744	NFKBIA/JUN/ATP6V1G1	0.628441521966741
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/278	194/9376	1.21693985018171	TUBA1B/TUBA1C/MYL12B/TNNT3/TUBA1A/TUBB2A/ACTC1	0.5337115808824
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/278	43/9376	1.56867993976911	CD36/PLPP3	0.653320932897604
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/278	73/9376	1.38602542623435	GADD45G/GADD45B/CDKN2A	0.578763188623092
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/278	104/9376	1.29717764250138	PEMT/PLPP3/ETNK2/CHPT1	0.53269811650204
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/278	44/9376	1.53302812295618	OSTC/KRTCAP2	0.619475544984766
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/278	44/9376	1.53302812295618	GTF2B/TAF9	0.619475544984766
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/278	105/9376	1.28482356971566	NFKBIA/GADD45G/GADD45B/TNFAIP3	0.513029518484842
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/278	75/9376	1.34906474820144	GSTM3/CDKN2A/CYCS	0.530526242743935
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/278	75/9376	1.34906474820144	ATP1B1/GPX8/HSP90B1	0.530526242743935
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/278	106/9376	1.27270259264287	NFKBIA/FOXO1/ZEB1/HSP90B1	0.493557098398734
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/278	169/9376	1.19739474692435	DDIT4/RPS27A/UBA52/UBC/RHEB/BNIP3	0.452642096535492
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/278	107/9376	1.2608081758892	LDHA/FOXO1/PDE3B/PDHA1	0.474276623485745
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/278	76/9376	1.33131389625142	GADD45G/GADD45B/CDKN2A	0.506920720638439
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/278	46/9376	1.46637472630591	FTH1/BLVRB	0.554253151316007
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/278	17/9376	1.98391874735506	GGT5	0.709747779630612
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/278	204/9376	1.15728593595712	CD63/RPS6/CD44/COL1A1/GPC1/FZD4/MYC	0.39701601112126
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/278	109/9376	1.23767408091875	NFKBIA/JUN/TGFBR2/FOS	0.436275234422451
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/278	78/9376	1.29717764250138	ARPC3/ARPC2/ELMO1	0.460684641151984
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/278	78/9376	1.29717764250138	JUN/FOS/C1R	0.460684641151984
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/278	110/9376	1.22642249836494	BMP2/TGFBR2/FBN1/MYC	0.417546495226738
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/278	80/9376	1.26474820143885	RPS6/FOXO3/EIF4EBP1	0.415685642285255
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/278	144/9376	1.17106314948042	PSMD8/GTF2B/VDAC2/RBPJ/CYCS	0.361597052477621
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/278	112/9376	1.20452209660843	NFKBIA/LAMB1/CYCS/HSPA8	0.380614250158891
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/278	243/9376	1.11034135654439	HNRNPA1/SRSF5/FUS/SF3B6/EIF4A3/CDC5L/SNRPE/HSPA8	0.30462798429441
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/278	178/9376	1.13685231590009	DKK1/JUN/FZD4/APCDD1/SERPINF1/MYC	0.322218535669819
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/278	19/9376	1.77508519500189	PDHA1	0.59114360685496
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/278	50/9376	1.34906474820144	CD36/CD81	0.432591875259064
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/278	82/9376	1.23390068433058	GSTM3/CES1/NME1	0.371853740527072
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/278	51/9376	1.3226124982367	PLPP3/CHPT1	0.403809866398915
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/278	116/9376	1.16298685189779	PDHA1/PGK1/TPI1/GAPDH	0.308752969059286
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/278	52/9376	1.29717764250138	HSD3B2/CYP11A1	0.375622624187592
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/278	150/9376	1.1242206235012	FZD4/TGFBR2/GADD45G/GADD45B/MYC	0.268082014952777
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	7/278	216/9376	1.09299227284839	NFKBIA/JUN/CD36/HSP90B1/FOS/CYCS/HSPA8	0.241691329783803
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/278	217/9376	1.08795544209793	GSTM3/KLF4/JUN/HSP90B1/FOS/MYC/EIF4EBP1	0.229141432187135
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/278	86/9376	1.17650995482684	JUN/MYC/EIF4EBP1	0.287438966277146
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/278	187/9376	1.0821374985573	NFKBIA/JUN/TXNIP/VDAC2/TXN/TNFAIP3	0.198318495908974
NA	NA	hsa04518	Integrin signaling	5/278	154/9376	1.09502008782584	LAMB1/COL1A1/FBN1/FLT1/PGF	0.207825243914434
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/278	22/9376	1.53302812295618	MAOA	0.437519940055963
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/278	56/9376	1.20452209660843	OSTC/KRTCAP2	0.268325139228631
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/278	157/9376	1.07409613710306	CEBPB/CD36/MERTK/ODC1/ELMO1	0.16365849604606
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/278	23/9376	1.46637472630591	GLUL	0.391433983869087
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/278	23/9376	1.46637472630591	ATP1B1	0.391433983869087
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/278	90/9376	1.1242206235012	NFKBIA/JUN/FOS	0.206983482526496
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/278	158/9376	1.06729806028595	GADD45G/GADD45B/CDKN2A/MYC/YWHAQ	0.149124090636651
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/278	226/9376	1.04462978289934	NFKBIA/ATP1B1/JUN/PDE3B/FOS/PPP1R1B/BDNF	0.118714431385656
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/278	97/9376	1.04309130015575	RASD1/FOS/NOS1AP	0.0745692796139561
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/278	133/9376	1.01433439714394	HLA-B/HLA-C/HLA-E/HLA-A	0.0291027378019748
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/278	98/9376	1.03244751137865	PLPP3/ARPC3/ARPC2	0.056441989948798
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/278	203/9376	0.99684587305525	LAMB1/JUN/COL1A1/MYL12B/FLT1/PGF	-0.0079415735165086
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/278	63/9376	1.07068630809638	AASS/PLOD1	0.0984001685810798
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/278	63/9376	1.07068630809638	PTGDS/GGT5	0.0984001685810798
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/278	99/9376	1.02201874863745	JUN/FOS/CDKN2A	0.0384982973510032
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/278	99/9376	1.02201874863745	C1R/KRT10/KRT19	0.0384982973510032
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/278	28/9376	1.20452209660843	ATP6V1G1	0.189450157151472
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/278	100/9376	1.01179856115108	CD44/CD36/CD59	0.0207340312003937
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/278	30/9376	1.1242206235012	PDHA1	0.119117758834694
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/278	140/9376	0.963617677286742	RPS6/EGR1/PDE3B/SERPINE1	-0.0758136746857833
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/278	31/9376	1.08795544209793	GLUL	0.085741085970536
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/278	32/9376	1.05395683453237	UGP2	0.0534429111821869
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/278	32/9376	1.05395683453237	LDHA	0.0534429111821869
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/278	32/9376	1.05395683453237	CYCS	0.0534429111821869
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/278	70/9376	0.963617677286742	NFKBIA/CD36	-0.0534063610659976
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/278	70/9376	0.963617677286742	GSTM3/HSD11B1	-0.0534063610659976
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/278	70/9376	0.963617677286742	EGLN3/JUN	-0.0534063610659976
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/278	71/9376	0.950045597324957	FOXO3/FOS	-0.0738549869677242
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/278	33/9376	1.02201874863745	PDHA1	0.0221483561826128
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/278	109/9376	0.928255560689063	NFKBIA/JUN/FOS	-0.131694301532131
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/278	109/9376	0.928255560689063	NFKBIA/FOXO1/CD36	-0.131694301532131
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/278	72/9376	0.936850519584333	NFKBIA/AZI2	-0.0940234643242437
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/278	73/9376	0.924016950822903	GSTM3/MAOA	-0.113920454028186
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/278	149/9376	0.905412582685529	MT-ND1/NDUFA4L2/NDUFS5/MT-ND2	-0.203437640947802
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/278	35/9376	0.963617677286742	TPI1	-0.037693184286141
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/278	36/9376	0.936850519584333	UGP2	-0.0663563766754472
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/278	115/9376	0.879824835783547	EGR1/FOS/NACA	-0.226657331943745
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/278	37/9376	0.911530235271243	GLUL	-0.0942498389077507
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/278	78/9376	0.864785095000922	IP6K3/TPI1	-0.20961008191459
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/278	78/9376	0.864785095000922	BTG1/TOB1	-0.20961008191459
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/278	38/9376	0.887542597500947	ATP1B1	-0.121419371784601
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/278	79/9376	0.853838448228759	GSTM3/HSD11B1	-0.228039639238814
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/278	232/9376	0.872240138923344	TMSB4X/MYL12B/RGCC/ARPC3/BAIAP2/ARPC2	-0.344433499788356
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/278	122/9376	0.829343082910721	NFKBIA/JUN/FOS	-0.33164551883214
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/278	122/9376	0.829343082910721	JUNB/FOS/CSH1	-0.33164551883214
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/278	41/9376	0.82260045622039	MAOA	-0.198985914682901
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/278	42/9376	0.803014731072285	MAOA	-0.223645192277364
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/278	85/9376	0.793567498942023	ENTPD2/NME1	-0.334188404644197
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/278	44/9376	0.76651406147809	AQP3	-0.271353091484124
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/278	128/9376	0.790467625899281	PDE3B/ENTPD2/NME1	-0.417222074349795
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/278	168/9376	0.803014731072285	FTH1/GLUL/VDAC2/TNFAIP3	-0.450340292088042
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/278	89/9376	0.757901543933393	GLUL/SLC38A2	-0.401129285809484
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/278	46/9376	0.733187363152956	PSMD8	-0.317087818962142
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/278	133/9376	0.760750797857954	FOS/PPP1R1B/MAOA	-0.485741167162772
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/278	134/9376	0.75507355309782	CALD1/RAMP1/RAMP2	-0.499160452022136
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/278	48/9376	0.702637889688249	HSD17B10	-0.361033124646469
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/278	48/9376	0.702637889688249	ATP1B1	-0.361033124646469
NA	NA	hsa04519	Cadherin signaling	10/278	404/9376	0.834817294679108	NFKBIA/FZD4/ARPC3/ARPC2/KRT10/PPP1R1B/CDH15/YWHAQ/PKP1/KRT19	-0.59326085675826
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/278	93/9376	0.72530362806529	EGR1/JUN	-0.46535597284554
NA	NA	hsa04382	Cornified envelope formation	5/278	217/9376	0.777111030069953	S100A11/KRT10/PKP1/KRT19/CLDN1	-0.580670127626877
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/278	142/9376	0.712534197993718	RPS27A/UBA52/UBC	-0.603351634818972
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/278	53/9376	0.636351296321433	ATP1B1	-0.464063281129302
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/278	54/9376	0.624567013056222	LDHA	-0.483626209905793
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/278	144/9376	0.702637889688249	KLF4/FZD4/MYC	-0.628570577204089
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/278	144/9376	0.702637889688249	NFKBIA/FOXO1/FOXO3	-0.628570577204089
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/278	55/9376	0.613211249182472	PLPP3	-0.502873784043085
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/278	103/9376	0.654885800097786	FUS/EIF4A3	-0.61561101405495
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/278	103/9376	0.654885800097786	LAMB1/COL1A1	-0.61561101405495
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/278	105/9376	0.642411784857828	NFKBIA/JUN	-0.644094553036418
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/278	191/9376	0.706316622094994	FOSB/PPP1R1B/MAOA/BDNF	-0.716789343307564
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/278	59/9376	0.571637605170101	NME1	-0.576944936131019
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/278	59/9376	0.571637605170101	PDE3B	-0.576944936131019
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/278	108/9376	0.624567013056222	EEF1A1/EIF4A3	-0.685940370673535
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/278	154/9376	0.657012052695506	JUN/RCAN1/FOS	-0.750173520560362
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/278	62/9376	0.543977721048967	RBPJ	-0.629721988957556
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/278	65/9376	0.518871057000553	PLPP3	-0.680385529152283
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/278	115/9376	0.586549890522365	DUSP1/MAOA	-0.779790893709637
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/278	116/9376	0.581493425948896	MYL12B/CLDN1	-0.792794914464255
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/278	116/9376	0.581493425948896	GLUL/SLC38A2	-0.792794914464255
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/278	66/9376	0.511009374318727	JUN	-0.696839452151939
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/278	117/9376	0.576523396667282	BAZ1A/MORF4L2	-0.805703740220956
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/278	68/9376	0.495979686838764	DHRS4L2	-0.729137405914657
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/278	166/9376	0.609517205512698	ATP1B1/PDE3B/VDAC2	-0.887281040384362
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/278	69/9376	0.488791575435304	PDE3B	-0.744993975158168
Organismal Systems	Immune system	hsa04611	Platelet activation	2/278	126/9376	0.53534315404819	COL1A1/MYL12B	-0.917871354310525
NA	NA	hsa04081	Hormone signaling	4/278	219/9376	0.616011300548602	RAMP1/CSH1/RAMP2/SLC16A10	-1.00507614138628
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/278	76/9376	0.443771298750473	ATP1B1	-0.851047472706134
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/278	79/9376	0.426919224114379	ATP6V1G1	-0.894114298897107
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/278	184/9376	0.549890522364717	MYL12B/SEMA4A/PLXNA4	-1.07784703465557
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/278	83/9376	0.406344803675132	NFKBIA	-0.949577512101711
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/278	86/9376	0.392169984942279	ENTPD2	-0.989825369179974
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/278	86/9376	0.392169984942279	ATP1B1	-0.989825369179974
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/278	238/9376	0.56683392781573	ETS2/BDNF/FLT1/PGF	-1.18318431747345
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/278	193/9376	0.524247959145637	NFKBIA/FOXO3/ELMO1	-1.16735270025076
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/278	90/9376	0.374740207833733	ATP1B1	-1.04184350085087
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/278	91/9376	0.370622183571824	PDE3B	-1.0545720175004
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/278	149/9376	0.452706291342765	RHEB/PLPP3	-1.1771136601038
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/278	93/9376	0.362651814032645	ATP1B1	-1.07971497050814
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	4/278	250/9376	0.539625899280575	CD63/LAPTM4A/OSBPL1A/ATP6V1G1	-1.28966147158081
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	5/278	298/9376	0.565882864178456	BMP2/TGFBR2/CSH1/ACVRL1/RELT	-1.3312359638761
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/278	154/9376	0.438008035130337	UGP2/NME1	-1.22917290279776
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/278	154/9376	0.438008035130337	ATP1B1/ACTC1	-1.22917290279776
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/278	98/9376	0.344149170459551	IP6K3	-1.14084329910081
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/278	99/9376	0.340672916212485	ACTC1	-1.15278895005166
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/278	101/9376	0.333926917871643	FZD4	-1.17641534464788
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/278	102/9376	0.330653124559176	ATP1B1	-1.18809960207328
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/278	105/9376	0.321205892428914	ACTC1	-1.22265658879705
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/278	168/9376	0.401507365536142	CSH1/MYC	-1.36825128743967
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/278	110/9376	0.306605624591236	PDE3B	-1.27869091345866
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/278	323/9376	0.52208388088291	DDIT4/ZEB1/CD44/CDKN2A/MYC	-1.5278888075447
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/278	173/9376	0.389903106416601	NFKBIA/CYCS	-1.41576843110171
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/278	115/9376	0.293274945261182	FOS	-1.33292445547553
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/278	181/9376	0.372669819945149	CEBPB/CYCS	-1.48968577926109
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/278	138/9376	0.244395787717652	YWHAQ	-1.56307567482852
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/278	143/9376	0.235850480454797	C1R	-1.6095705426056
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/278	212/9376	0.318175648160717	FLT1/PGF	-1.75522569680293
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/278	254/9376	0.265563926811307	VDAC2/FLT1	-2.07424902280927
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/278	195/9376	0.172957019000184	VDAC2	-2.04002487067494
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/278	370/9376	0.0911530235271242	CSH1	-3.11788955697837