category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	54/506	233/9376	4.2944239936216	COL4A1/ITGB1/ACTB/COL4A2/SYNE2/FN1/TPM4/LMOD1/COL6A1/FBLN1/FHL1/TPM1/TNNT1/MYL9/NID1/ACTG1/SYNPO2/MYH10/MYH9/DSP/COL11A1/CSRP1/TLN1/ANK2/VCL/COL6A2/PDLIM5/SDC2/FBLN2/THBS1/DMD/TNNI3/ITGA1/FBN2/PDLIM2/FBN1/ANKRD1/TPM2/JUP/PDLIM7/PLEC/LAMA2/SYNE3/PDLIM4/FMNL2/SPTAN1/TMEM43/ZYX/DAG1/MYH13/TNNT2/CSRP2/COL5A3/SUN1	12.1622010861336
NA	NA	hsa04518	Integrin signaling	38/506	154/9376	4.57224988450285	COL4A1/ITGB1/ACTB/COL4A2/FN1/FLNA/COL6A1/PIK3R1/LAMC1/PDGFD/ARHGEF6/CCND2/ACTG1/PDGFRA/TLN1/ACTN4/VCL/PDGFRB/LAMA4/COL6A2/LIMS2/HGF/VTN/THBS1/IGF1R/FREM1/VEGFA/ITGA1/FLNB/FERMT2/FBN1/FERMT1/ACTN1/LAMA2/VEGFB/PIK3CA/PXN/ILK	10.6755121470669
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	42/506	203/9376	3.83371950388442	COL4A1/ITGB1/ACTB/COL4A2/FN1/FLNA/COL6A1/PIK3R1/LAMC1/MYL9/PDGFD/CCND2/ACTG1/PDGFRA/TLN1/ACTN4/VCL/PDGFRB/LAMA4/COL6A2/HGF/CAPN2/VTN/PTEN/THBS1/IGF1R/MYL12A/BCL2/VEGFA/ITGA1/FLNB/ACTN1/ROCK1/LAMA2/DOCK1/VEGFB/ZYX/PIK3CA/PXN/MYLK/PAK2/ILK	9.74873507023088
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	40/506	253/9376	2.92958802668375	PLCG2/ITGB1/ACTB/PIK3R1/MYL9/ARPC5/ACTG1/TLN1/ACTN4/TIFA/IL1R1/VCL/CAST/ITPR2/CAPN2/MAP1LC3B/CD14/MYL12A/BCL2/BCL2L1/MAP1LC3C/CALCOCO2/CBX3/CYTH3/ACTN1/WASF2/CAPNS1/WIPI2/ROCK1/DOCK1/MAPK14/FBXW11/PIK3CA/PXN/RIPK1/SQSTM1/ILK/IRF3/ATG14/CASP4	7.43113421905402
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	47/506	362/9376	2.40578254318346	COL4A1/ITGB1/COL4A2/FN1/PRLR/COL6A1/PIK3R1/LAMC1/IGF2/IRS1/PDGFD/CCND2/PDGFRA/PDGFRB/LAMA4/COL6A2/FGF10/JAK2/HGF/YWHAE/VTN/PTEN/THBS1/IGF1R/CREB3L1/MAGI1/BCL2/EIF4B/VEGFA/ITGA1/IFNAR1/BCL2L1/IL6R/OSMR/ATF4/FGFR1/PPP2R5E/PHLPP1/LAMA2/VEGFB/EIF4EBP1/BCL2L11/PIK3CA/CDKN1B/YWHAZ/CDK2/PRKAA1	6.51497481367564
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	32/506	204/9376	2.90661086569015	PLCG2/ITGB1/ACTB/GPC3/FN1/WNT2/FLNA/PIK3R1/IGF2/TGFB2/ACTG1/MMP2/ANK2/ITPR2/SDC2/HGF/VTN/THBS1/IGF1R/IQGAP1/EIF4B/VEGFA/HIF1A/RRAS/FGFR1/ROCK1/MAPK14/PIK3CA/PXN/PTPN11/FZD6/RRAS2	6.57573360926495
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	22/506	116/9376	3.51424287856072	PLCG2/ITGB1/ACTB/PIK3R1/MYL9/ACTG1/MMP2/ACTN4/VCL/CYBA/GNAI1/MYL12A/ACTN1/CTNND1/ROCK1/MAPK14/CLDN23/PIK3CA/PXN/PTPN11/NCF1/JAM3	6.50773435338544
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	33/506	232/9376	2.63568215892054	ITGB1/ACTB/IQGAP2/FN1/CFL2/PIK3R1/MYL9/PDGFD/ARHGEF6/ARPC5/ACTG1/MYH10/PDGFRA/MYH9/ACTN4/C7/VCL/PDGFRB/FGF10/IQGAP1/MYL12A/ITGA1/RRAS/FGFR1/ACTN1/WASF2/ROCK1/DOCK1/PIK3CA/PXN/MYLK/PAK2/RRAS2	6.02523356996517
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/506	101/9376	3.48577466442296	PLCG2/COL4A1/COL4A2/FN1/PIK3R1/TGFB2/MMP2/F3/TGFBR1/THBD/JAK2/PIM1/BCL2/VEGFA/MAPK14/VEGFB/PIK3CA/CDKN1B/STAT5B	5.99880260962204
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	25/506	169/9376	2.74107163739271	PIK3R1/IRS1/IRS2/CTSD/MAP1LC3B/PTEN/IGF1R/BCL2/DAPK1/HIF1A/OPTN/BCL2L1/MAP1LC3C/CALCOCO2/RRAS/WIPI2/SH3GLB1/VPS41/DAPK3/PIK3CA/NBR1/SQSTM1/ATG14/RRAS2/PRKAA1	5.45506598490184
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	16/506	80/9376	3.70592885375494	PLCG2/PIK3R1/PDGFD/PDGFRA/PDGFRB/JAK2/HGF/PTEN/IGF1R/BCL2/VEGFA/BCL2L1/IL6R/EIF4EBP1/BCL2L11/PIK3CA	5.80513596874644
NA	NA	hsa04517	IgSF CAM signaling	36/506	299/9376	2.23099395878224	PLCG2/ITGB1/ACTB/CADM3/PIK3R1/NRP1/NFASC/MYL9/ARPC5/ACTG1/MYH10/MYH9/TJP1/ACTN4/ANK2/VCL/MBP/IQGAP1/MAGI1/MYL12A/FGFR1/PMP22/ACTN1/EPB41L2/CNTNAP2/MAPK14/SPTAN1/PIK3CA/PXN/PTPN11/MYLK/MPDZ/PAK2/PPFIA1/JAM3/NRP2	5.16677363434436
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/506	112/9376	3.14342179559571	ITGB1/LAMC1/TGFB2/HLA-DRA/LAMA4/JAK2/GNAI1/IFNGR2/BCL2/HLA-DRB1/BCL2L1/HLA-DQB1/HLA-DPB1/HLA-DPA1/LAMA2/MAPK14/HLA-DQA1/SOCS1/LDLR	5.45025055002101
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/506	93/9376	3.38713927493731	ACTB/MYL9/ACTG1/TJP1/ACTN4/TGFBR1/VCL/IGF1R/IQGAP1/MYL12A/TCF7L2/FGFR1/ACTN1/WASF2/CTNND1/ROCK1/HEG1	5.52553257936872
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/506	194/9376	2.48335438653682	ACTB/TPM4/TPM1/TNNT1/MYL9/ACTG1/MYH10/MYH9/DNAH10/DYNC1I2/ACTA2/MYO1E/TNNI3/MYL12A/DCTN1/TPM2/DYNC2H1/MYO18A/DYNC1H1/KIFAP3/DYNLRB1/KIF1B/MYH13/TNNT2/MYO1C/KIF13A	4.98627501049952
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	37/506	333/9376	2.05884936319719	COL4A1/ITGB1/COL4A2/FN1/WNT2/COL6A1/PIK3R1/LAMC1/CCND2/PDGFRB/LAMA4/COL6A2/JAG1/VTN/PTEN/THBS1/MAML2/CREB3L1/MAGI1/TCF7L2/VEGFA/ITGA1/IFNAR1/MAML3/DLG3/PPP2R5E/LAMA2/EIF4EBP1/LLGL2/ATP6V1B2/PIK3CA/PXN/CHD4/CDKN1B/IRF3/FZD6/CDK2	4.69893154089908
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	23/506	168/9376	2.53679653679654	IL6ST/PRLR/PIK3R1/FHL1/CCND2/SOCS2/CISH/PDGFRA/PDGFRB/LIFR/JAK2/IFNGR2/PIM1/BCL2/STAT6/IFNAR1/BCL2L1/IL6R/OSMR/SOCS1/PIK3CA/PTPN11/STAT5B	4.80051073733873
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	23/506	170/9376	2.50695187165775	ITGB1/ACTB/MYL9/ARPC5/ACTG1/MYH10/CFTR/MYH9/TJP1/ACTN4/CGNL1/MAGI1/MYL12A/DLG3/ACTN1/AMOTL2/ROCK1/LLGL2/CLDN23/MPDZ/AMOTL1/JAM3/PRKAA1	4.73573556702592
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/506	78/9376	3.32583358670315	ITGB1/ACTB/FN1/PIK3R1/ARPC5/ACTG1/VCL/CLTC/WASF2/DOCK1/PIK3CA/PXN/ARHGEF26/ILK	4.92640661684985
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	29/506	248/9376	2.16677291852607	ACTB/FLNA/MYL9/AHNAK/ARPC5/ACTG1/DYNC1I2/CD14/MYL12A/TCF7L2/BCL2/DCTN1/RRAS/CYTH3/S100A10/DYNC2H1/MAPK14/VPS41/DYNC1H1/FYCO1/PIK3C2A/ABI1/PIK3CA/DYNLRB1/RIPK1/ARHGEF26/CASP4/SNX9/GSDMD	4.44757675502855
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	17/506	109/9376	2.88994451898321	IL6ST/HLA-DRA/TGFBR1/IL1R1/JAK2/IFNGR2/HLA-DRB1/HIF1A/STAT6/HLA-DQB1/IL6R/HLA-DPB1/HLA-DPA1/MAPK14/HLA-DQA1/AHR/STAT5B	4.74014699266921
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/506	93/9376	2.98865230141527	HLA-DRA/JAG1/JAK2/MAML2/IFNGR2/HLA-DRB1/MAF/STAT6/HLA-DQB1/MAML3/HLA-DPB1/HLA-DPA1/MAPK14/HLA-DQA1/STAT5B	4.60315122618694
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/506	105/9376	2.82356484095615	BNIP3L/MAP1LC3B/HIF1A/OPTN/BCL2L1/AMFR/MAP1LC3C/CALCOCO2/RRAS/ATF4/CITED2/NBR1/SQSTM1/PINK1/TBC1D17/RRAS2	4.48798767874127
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	26/506	224/9376	2.15076228119706	PIK3R1/NRP1/CCND2/TGFB2/TLN1/HLA-DRA/TGFBR1/IL1R1/PTEN/CREB3L1/HLA-DRB1/BCL2L1/ETS1/HLA-DQB1/ADCY3/HLA-DPB1/ATF4/HLA-DPA1/LTBR/HLA-DQA1/KAT5/PIK3CA/KAT2B/STAT5B/CDK2/MAP3K3	4.16342464480869
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/506	78/9376	3.08827404479578	ITGB1/TGFB2/HLA-DRA/JAK2/CYBA/IFNGR2/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/MAPK14/HLA-DQA1/NCF1	4.42322577629488
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/506	99/9376	2.80752185890526	ITGB1/ACTB/TPM4/TPM1/SLC8A1/TGFB2/ACTG1/DMD/TNNI3/ITGA1/TPM2/LAMA2/DAG1/TNNT2/PRKAA1	4.31813746564823
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/506	89/9376	2.91477550295332	COL4A1/ITGB1/COL4A2/FN1/COL6A1/LAMC1/LAMA4/COL6A2/VTN/THBS1/FREM1/ITGA1/LAMA2/DAG1	4.33485155516388
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/506	122/9376	2.5819996112227	PLCG2/PIK3R1/IRS1/SOCS2/IGFBP3/SSTR1/IRS2/ITPR2/JAK2/CREB3L1/GNAI1/ADCY3/ATF4/MAPK14/SOCS1/PIK3CA/STAT5B	4.20068994173274
Organismal Systems	Immune system	hsa04611	Platelet activation	17/506	126/9376	2.50003136959659	PLCG2/ITGB1/ACTB/PIK3R1/ACTG1/TLN1/ITPR2/PRKG1/SNAP23/GNAI1/MYL12A/ADCY3/APBB1IP/ROCK1/MAPK14/PIK3CA/MYLK	4.04868356089857
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/506	93/9376	2.78940881465426	COL4A1/ITGB1/COL4A2/FN1/PIK3R1/LAMC1/LAMA4/PTEN/BCL2/BCL2L1/LAMA2/PIK3CA/CDKN1B/CDK2	4.14196054959605
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	15/506	105/9376	2.64709203839639	ITGB1/ACTB/TPM4/TPM1/SLC8A1/TGFB2/ACTG1/DMD/TNNI3/ITGA1/ADCY3/TPM2/LAMA2/DAG1/TNNT2	4.05366927901501
NA	NA	hsa04519	Cadherin signaling	38/506	404/9376	1.74288733221148	ACTB/WNT2/ARPC5/ACTG1/PDGFRA/GJA1/PCDH10/DSP/LIMA1/TJP1/ACTN4/VCL/PDGFRB/KRT18/YWHAE/MYO1E/IGF1R/TCF7L2/YAP1/RRAS/JUP/FGFR1/ACTN1/AMOTL2/CTNND1/ROCK1/RERE/MAPK14/AJUBA/MPDZ/AMOTL1/YWHAZ/CTNND2/FZD6/MYO1C/RRAS2/ATN1/SHOC2	3.64559222695467
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/506	66/9376	3.08827404479578	TGFB2/HLA-DRA/IFNGR2/HLA-DRB1/MAF/STAT6/HLA-DQB1/IL18R1/HLA-DPB1/HLA-DPA1/HLA-DQA1	4.06615289260033
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	19/506	157/9376	2.24244102615745	PIK3R1/CCND2/TGFB2/IGFBP3/TGFBR1/HIPK3/ITPR2/CAPN2/PTEN/ETS1/RRAS/MAPK14/EIF4EBP1/RBBP4/FBXW11/PIK3CA/SQSTM1/RRAS2/CDK2	3.74958142477036
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/506	170/9376	2.17995814926761	PLCG2/ACTB/WNT2/PIK3R1/IGF2/TGFB2/ACTG1/TGFBR1/HGF/PTEN/IGF1R/TCF7L2/TXNRD1/BCL2L1/PHF10/PIK3CA/SMARCC1/FZD6/SMARCD3/GSTT2B	3.70812756544212
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	23/506	212/9376	2.01029159519726	ITGB1/ACTB/PIK3R1/PDGFD/ACTG1/PDGFRA/TLN1/PDGFRB/FGF10/HGF/THBS1/IGF1R/GNAI1/MAGI1/VEGFA/ADCY3/RRAS/APBB1IP/FGFR1/CTNND1/MAPK14/VEGFB/PIK3CA	3.55362189416523
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/506	70/9376	2.91180124223603	ACTB/ACTG1/HLA-DRA/DMD/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/LAMA2/HLA-DQA1/DAG1	3.83450512071415
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/506	103/9376	2.518592424882	COL4A1/COL4A2/FN1/PIK3R1/LAMC1/TGFB2/ACTN4/IL1R1/VCL/LAMA4/CD14/ACTN1/LAMA2/PIK3CA	3.70125322102214
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/506	106/9376	2.44731150719666	PIK3R1/PDGFD/PDGFRA/PDGFRB/PTEN/IGF1R/CREB3L1/TCF7L2/BCL2/ATF4/FGFR1/PIK3CA/CDKN1B/CDK2	3.57910275755671
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	17/506	142/9376	2.21833769414908	ACTB/PIK3R1/ACTG1/MMP2/IL1R1/THBD/MAP2K5/SDC2/CYBA/BCL2/VEGFA/MAPK14/PIK3CA/SQSTM1/GSTT2B/NCF1/PRKAA1	3.4939445220889
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/506	133/9376	2.22913013759696	PIK3R1/IRS1/CCND2/TGFB2/TGFBR1/IRS2/PTEN/IGF1R/FBXO32/FBXO25/MAPK14/BCL2L11/PIK3CA/CDKN1B/CDK2/PRKAA1	3.40970100925456
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/506	86/9376	2.58553175843368	ITGB1/ACTB/SLC8A1/ACTG1/GJA1/DSP/DMD/TCF7L2/ITGA1/JUP/LAMA2/DAG1	3.52789296857054
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/506	75/9376	2.71768115942029	CCND2/IGFBP3/SESN1/PTEN/THBS1/BCL2/BCL2L1/SHISA5/PPM1D/AIFM2/CDK2	3.56703563732416
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/506	110/9376	2.35831836148042	PLCG2/PIK3R1/EPAS1/IGF1R/PFKP/IFNGR2/BCL2/VEGFA/HIF1A/IL6R/LTBR/EIF4EBP1/PIK3CA/CDKN1B	3.42255828525935
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/506	142/9376	2.08784724155208	PLCG2/PIK3R1/TGFB2/TGFBR1/IL1R1/ITPR2/CYBA/IFNGR2/IFNAR1/MAPK14/TYROBP/SOCS1/PIK3CA/FOSL2/SQSTM1/NCF1	3.11972446452544
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/506	70/9376	2.64709203839639	PIK3R1/TGFB2/EPAS1/HGF/VEGFA/HIF1A/ETS1/PIK3CA/PTPN11/PAK2	3.30357712715553
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/506	155/9376	2.03228356496239	ITGB1/ACTB/ACTG1/HLA-DRA/DYNC1I2/CYBA/THBS1/CD14/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/DYNC2H1/DYNC1H1/HLA-DQA1/ATP6V1B2/NCF1	3.09510179941658
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/506	71/9376	2.6098090519401	PRLR/PIK3R1/CCND2/SOCS2/CISH/JAK2/MAPK14/SOCS1/PIK3CA/STAT5B	3.25195432725352
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/506	184/9376	1.91338717992782	PLCG2/ITGB1/CFL2/PIK3R1/NRP1/MYL9/SEMA3C/DPYSL2/GNAI1/MYL12A/SEMA6D/RRAS/EFNB2/ROCK1/PLXNB2/PIK3CA/PTPN11/PAK2/ILK	2.98853194212127
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/506	50/9376	2.96474308300395	TGFB2/SDC2/HGF/THBS1/LRP1/ACKR1/HBA2/HBA1	3.32691842167961
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/506	73/9376	2.53830743407873	PIK3R1/PDGFD/PDGFRA/PDGFRB/FGF10/HGF/PTEN/IGF1R/FGFR1/PIK3CA	3.151317383293
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	20/506	200/9376	1.85296442687747	ITGB1/ACTB/ARPC5/ACTG1/MYH10/MYH9/TJP1/IL1R1/MYO1E/CYTH3/WASF2/ROCK1/MAPK14/CLDN23/ABI1/RIPK1/PTPN11/PAK2/MYO1C/CASP4	2.91218057884318
Human Diseases	Immune disease	hsa05310	Asthma	6/506	32/9376	3.47430830039526	HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/HLA-DQA1	3.34858612212225
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	20/506	205/9376	1.80777017256339	PLCG2/PIK3R1/CCND2/HLA-DRA/NCOR2/BCL2/HLA-DRB1/IFNAR1/HLA-DQB1/HLA-DPB1/PSMC3/HLA-DPA1/MAPK14/HLA-DQA1/BCL2L11/PIK3CA/RIPK1/CDKN1B/IRF3/CDK2	2.79290062380979
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/506	205/9376	1.80777017256339	IL6ST/PIK3R1/CCND2/ACTN4/YWHAE/HDAC9/CREB3L1/ATF4/LTBR/ACTN1/PIK3CA/PXN/CHD4/CDKN1B/YWHAZ/IRF3/KAT2B/HDAC5/STAT5B/CDK2	2.79290062380979
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/506	88/9376	2.31620553359684	SERPINE2/SERPING1/F3/C7/THBD/C1QA/VTN/CFD/C1QB/A2M/CD46	2.96280474657944
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/506	44/9376	2.94789795185052	DYNC1I2/CREB3L1/VAMP2/DCTN1/ADCY3/DYNC2H1/DYNC1H1	3.09317335770697
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/506	90/9376	2.26473429951691	PIK3R1/IRS1/IRS2/SESN1/IGF1R/CREB3L1/ADCY3/ATF4/EIF4EBP1/PIK3CA/PRKAA1	2.87942186736021
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/506	90/9376	2.26473429951691	PIK3R1/EML4/JAK2/PTEN/IFNGR2/HIF1A/MAPK14/PIK3CA/PTPN11/BATF3/MAP3K3	2.87942186736021
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/506	238/9376	1.71282426013884	PLCG2/PIK3R1/IGF2/PDGFD/PDGFRA/PLA2G2A/PDGFRB/FGF10/HGF/IGF1R/VEGFA/BCL2L1/ETS1/RRAS/RASAL2/FGFR1/VEGFB/PIK3CA/PTPN11/PAK2/RRAS2/SHOC2	2.66038481538376
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/506	117/9376	2.05884936319719	ACTB/ACTG1/MORF4L1/CDK2AP2/YY1/PHF10/KAT5/RBBP4/BAZ1B/CHD4/BCL7A/SMARCC1/SMARCD3	2.7526066534282
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	14/506	130/9376	1.99550015202189	COL4A1/COL4A2/PIK3R1/MMP2/TGFBR1/ACTA2/CREB3L1/GNAI1/VEGFA/ADCY3/ATF4/MAPK14/VEGFB/PIK3CA	2.7298271511521
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/506	157/9376	1.88837139044838	ACTB/WNT2/CCND2/TGFB2/ACTG1/TGFBR1/YWHAE/TCF7L2/YAP1/NKD1/DLG3/LLGL2/FBXW11/AJUBA/YWHAZ/FZD6	2.68102935575514
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/506	144/9376	1.93017127799737	IL6ST/WNT2/PIK3R1/LIFR/JAK2/IGF1R/ID4/FGFR1/MAPK14/PCGF5/LEFTY2/PIK3CA/MEIS1/REST/FZD6	2.68655267401307
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/506	17/9376	4.35991629853522	MYH10/MYH9/DAG1/NRP2	3.31159548825534
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/506	59/9376	2.51249413813894	PIK3R1/IRS1/IRS2/PRKG1/GNAI1/ADCY3/PNPLA2/PIK3CA	2.78343282744615
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/506	71/9376	2.34882814674609	PIK3R1/PDGFRA/PDGFRB/PTEN/PFKP/HIF1A/GLS/FGFR1/PIK3CA	2.72475019521477
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	13/506	122/9376	1.97447029093501	PIK3R1/IRS1/CFTR/IRS2/IGF1R/PFKP/CREB3L1/PPP2R5E/STRADB/EIF4EBP1/RAB14/PIK3CA/PRKAA1	2.58751488976935
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/506	137/9376	1.89354029023975	ACTB/PIK3R1/ACTG1/CTSD/ITPR2/CAPN2/BCL2/BCL2L1/ATF4/BCL2L11/SPTAN1/PIK3CA/RIPK1/PARP4	2.5162919405015
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/506	50/9376	2.59415019762846	HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/LTBR/HLA-DQA1	2.69938991275412
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/506	39/9376	2.85071450288842	HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/HLA-DQA1	2.76609530222558
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	17/506	180/9376	1.75002195871761	PIK3R1/CD74/HLA-DRA/JAK2/IFNGR2/BCL2/HLA-DRB1/IFNAR1/BCL2L1/HLA-DQB1/HLA-DPB1/HLA-DPA1/EIF4EBP1/HLA-DQA1/PIK3CA/PTPN11/IRF3	2.42666505726323
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/506	62/9376	2.39092184113222	PIK3R1/IRS1/IRS2/IGF1R/ADCY3/EIF4EBP2/PIK3CA/PRKAA1	2.6243970529556
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/506	100/9376	2.03826086956522	HLA-DRA/IL1R1/CD14/HLA-DRB1/ITGA1/HLA-DQB1/IL6R/HLA-DPB1/ANPEP/HLA-DPA1/HLA-DQA1	2.49301678859511
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/506	140/9376	1.85296442687747	SLC8A1/TGFBR1/JAG1/ACTA2/ITPR2/MAP1LC3B/GNAI1/ADCY3/MAP1LC3C/RRAS/MYLK/HDAC5/RRAS2/PRKAA1	2.42857802840369
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/506	51/9376	2.54328450747888	PLCG2/ACTB/ACTG1/CFTR/TJP1/ADCY3/ATP6V1B2	2.63940327344825
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	20/506	227/9376	1.63256777698456	PIK3R1/PDGFRA/IL1R1/AKAP13/ITPR2/CREB3L1/GNAI1/VEGFA/PTGER2/IL6R/ADCY3/CCL4L2/ATF4/ROCK1/MAPK14/EIF4EBP1/PIK3CA/PXN/RIPK1/IRF3	2.3042641690772
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/506	89/9376	2.08198250210952	PDGFD/PDGFRA/GJA1/TJP1/PDGFRB/MAP2K5/ITPR2/PRKG1/GNAI1/ADCY3	2.44949526704065
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/506	77/9376	2.16580257686977	PIK3R1/TGFB2/TGFBR1/BCL2L1/PIK3CA/BCR/CDKN1B/PTPN11/STAT5B	2.45330382737058
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	15/506	157/9376	1.77034817854535	C1QA/JAK2/MFGE8/THBS1/HIF1A/LRP1/C1QB/PTGER2/XKR4/DOCK1/MAPK14/VPS41/RAB14/ANO6/PTPN11	2.32484533275006
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/506	78/9376	2.13803587716631	ITGB1/CFL2/SERPING1/C1QA/CD14/GNAI1/C1QB/MAPK14/IRF3	2.41050241407499
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	17/506	187/9376	1.68451311534315	ANTXR2/ITPR2/YWHAE/CYBA/MAP1LC3B/BCL2/IFNAR1/BCL2L1/NEK7/MAP1LC3C/MAPK14/RIPK1/IFI16/CARD16/IRF3/CASP4/GSDMD	2.25822669966646
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/506	79/9376	2.11097213188573	SLC6A2/VAMP2/CLTC/AP2A2/STX2/ATP6V1B2/AP2M1/AP2A1/AP2B1	2.3683418097734
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/506	323/9376	1.49155031265679	PLCG2/PIK3R1/IRS1/TPM1/CCND2/MARCKS/TGFB2/PDGFRA/FSCN1/PDGFRB/IRS2/PTEN/THBS1/PIM1/BCL2/VEGFA/GLS/ROCK1/IGF2BP1/BCL2L11/SOCS1/PIK3CA/FOXP1/CDKN1B/ZEB2/HDAC5	2.14719785362397
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	12/506	120/9376	1.85296442687747	PLCG2/PIK3R1/IRS1/MAP2K5/YWHAE/BCL2/SORT1/ATF4/MAPK14/PIK3CA/PTPN11/MAP3K3	2.24599588341314
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/506	68/9376	2.17995814926761	PIK3R1/CD14/PIM1/TCF7L2/JUP/EIF4EBP1/PIK3CA/STAT5B	2.3323405328348
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/506	44/9376	2.52676967301473	HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/HLA-DQA1	2.42444080370723
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/506	163/9376	1.70518198792405	PIK3R1/TGFB2/TGFBR1/JAK2/CREB3L1/BCL2/STAT6/IFNAR1/ATF4/MAPK14/PIK3CA/YWHAZ/IRF3/STAT5B/CDK2	2.16916987369313
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/506	45/9376	2.47061923583663	HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/HLA-DQA1	2.36179115142195
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	24/506	300/9376	1.48237154150198	FLNA/IGF2/PDGFD/TGFB2/PDGFRA/TGFBR1/IL1R1/PDGFRB/FGF10/MAP2K5/HGF/IGF1R/CD14/VEGFA/RRAS/ATF4/FGFR1/MAP4K4/MAPK14/VEGFB/PAK2/PPP5C/RRAS2/MAP3K3	2.02812233707381
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	15/506	166/9376	1.67436544597362	IRS1/MYL9/SLC8A1/IRS2/KCNMA1/ITPR2/PDE3A/PRKG1/KCNJ8/CREB3L1/GNAI1/ADCY3/ATF4/ROCK1/MYLK	2.09372011208392
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/506	138/9376	1.7455461992324	ITGB1/ACTB/FN1/PIK3R1/ARPC5/ACTG1/WASF2/ROCK1/DOCK1/MAPK14/PIK3CA/PXN/IRF3	2.10728954018407
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/506	98/9376	1.89078002742599	PLCG2/CFL2/PIK3R1/MARCKS/ARPC5/ASAP1/WASF2/DOCK1/PIK3CA/NCF1	2.11716843976566
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/506	47/9376	2.36548650239677	PIK3R1/IRS1/SOCS2/IRS2/SOCS1/PIK3CA	2.24139232613088
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/506	99/9376	1.87168123927017	HLA-DRA/KRT18/C1QA/HLA-DRB1/CFD/C1QB/HLA-DQB1/HLA-DPB1/HLA-DPA1/HLA-DQA1	2.08243092544116
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/506	61/9376	2.12635262100693	SLC8A1/SLC40A1/MT1E/MT2A/MT1F/SLC30A1/MT1G	2.10788517092725
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	15/506	173/9376	1.60661655509607	ACTB/PIK3R1/ACTG1/HLA-DRA/JAK2/IFNGR2/HLA-DRB1/IFNAR1/HLA-DQB1/CALCOCO2/HLA-DPB1/HLA-DPA1/HLA-DQA1/PIK3CA/IRF3	1.92340918514815
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	20/506	250/9376	1.48237154150198	RAB11FIP1/ARPC5/PDGFRA/TGFBR1/DAB2/ASAP1/IGF1R/CLTC/CYTH3/AP2A2/SH3GLB1/SNX6/EHD2/VPS4B/ARFGEF1/SH3GLB2/AP2M1/AP2A1/AP2B1/LDLR	1.84633514520901
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/506	103/9376	1.79899458920143	COL4A1/COL4A2/COL6A1/SLC8A1/COL11A1/COL8A2/COL6A2/COL21A1/SLC15A1/COL5A3	1.9473831479772
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/506	205/9376	1.53660464667888	MT-ND3/MT-ATP8/PIK3R1/IRS1/TGFB2/MMP2/MT-ND4L/TGFBR1/CTSD/CYBA/PTEN/TNNI3/MAPK14/PIK3CA/NDUFB10/NDUFA3/NCF1	1.85533398403748
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/506	76/9376	1.95048887039734	ACTB/ACTG1/CFTR/ITPR2/GNAI1/SLC4A2/ADCY3/MYLK	1.98706212071765
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/506	76/9376	1.95048887039734	PLCG2/PIK3R1/PDGFRA/PDGFRB/PTEN/IGF1R/PIK3CA/CAMK1D	1.98706212071765
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/506	17/9376	3.26993722390142	INMT/TXNRD1/PAPSS2	2.23729200414068
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/506	150/9376	1.60590250329381	WNT2/PIK3R1/TGFB2/TGFBR1/FGF10/HGF/TCF7L2/BCL2/JUP/PIK3CA/CDKN1B/FZD6/CDK2	1.78665515963378
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/506	53/9376	2.09769557759714	SLC8A1/CLTC/AP2A2/AP2M1/AP2A1/AP2B1	1.9139963000906
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	18/506	227/9376	1.4693109992861	MT-ND3/MT-ATP8/PIK3R1/MT-ND4L/HGF/CYBA/PTEN/VEGFA/HIF1A/CYP1A2/MAPK14/AHR/PIK3CA/NDUFB10/PTPN11/NDUFA3/GSTT2B/NCF1	1.70956624595056
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/506	41/9376	2.25971271570423	MMP2/THBS1/DAPK1/VEGFA/DAPK3	1.93065808085177
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/506	54/9376	2.05884936319719	HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/HLA-DQA1	1.86369824857005
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/506	95/9376	1.7554399833576	TGFB2/HLA-DRA/HLA-DRB1/VEGFA/HLA-DQB1/HLA-DPB1/HLA-DPA1/HLA-DQA1/ATP6V1B2	1.76751647329663
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/506	139/9376	1.59968151960645	PIK3R1/MMP2/KRT18/CTSD/ITPR2/CREB3L1/GNAI1/BCL2/ADCY3/ATF4/PIK3CA/NCOA1	1.70122470319649
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/506	154/9376	1.5641907499615	TPM4/TPM1/SLC8A1/TNNI3/CREB3L1/GNAI1/BCL2/ADCY3/TPM2/ATF4/PPP2R5E/MAPK14/TNNT2	1.68605931813614
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/506	110/9376	1.68451311534315	FST/TGFB2/TGFBR1/THBS1/PITX2/ID4/LTBP1/FBN1/ROCK1/LEFTY2	1.72476946548306
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/506	42/9376	2.20591003199699	SLC40A1/GPX4/MAP1LC3B/MAP1LC3C/NCOA4	1.87070256494357
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/506	155/9376	1.55409919673594	WNT2/ITPR2/CREB3L1/GNAI1/TCF7L2/ADCY3/ATF4/AHR/CDKN1B/ASH2L/FZD6/CDK2/LDLR	1.66135883499723
NA	NA	hsa04382	Cornified envelope formation	17/506	217/9376	1.45163111783028	COL4A1/COL4A2/DSP/TJP1/KRT18/PPL/DST/S100A8/JUP/S100A10/PPP2R5E/PLEC/FURIN/CLDN23/TCHH/S100A9/S100A13	1.60763991968304
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	17/506	217/9376	1.45163111783028	PIK3R1/JAG1/FGF10/JAK2/CREB3L1/GNAI1/BCL2/VEGFA/PAQR8/ADCY3/ATF4/CYP1A2/EIF4EBP1/AHR/PIK3CA/STAT5B/GSTT2B	1.60763991968304
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/506	83/9376	1.78598980903853	AUTS2/CBX3/CBX7/EZH1/PCGF5/YY1/RBBP4/ASXL1	1.71781772425572
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/506	158/9376	1.52459098413969	WNT2/PIK3R1/IRS1/PTEN/IGF1R/LPIN1/EIF4B/STRADB/EIF4EBP1/ATP6V1B2/PIK3CA/FZD6/PRKAA1	1.58829109373912
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/506	99/9376	1.68451311534315	PIK3R1/MMP2/JAG1/IGF1R/BCL2/ADCY3/MAPK14/PIK3CA/CDKN1B	1.63528961739975
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/506	160/9376	1.50553359683794	ITGB1/CADM3/NFASC/HLA-DRA/SDC2/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/CNTNAP2/HLA-DQA1/CLDN23/JAM3	1.54041545869855
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/506	60/9376	1.85296442687747	PLCG2/PIK3R1/VEGFA/MAPK14/PIK3CA/PXN	1.58303636385544
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/506	103/9376	1.61909513028128	PIK3R1/TGFB2/TGFBR1/C1QA/GNAI1/IFNGR2/C1QB/MAPK14/PIK3CA	1.50891562971597
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/506	149/9376	1.49232034379394	PLCG2/PIK3R1/PDGFD/PDGFRA/PDGFRB/AGPAT4/ADCY3/RRAS/CYTH3/PIK3CA/PTPN11/RRAS2	1.44680413988551
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/506	134/9376	1.52109020116807	MYL9/MYH10/MYH9/PLA2G2A/KCNMA1/ACTA2/ITPR2/PRKG1/ADCY3/ROCK1/MYLK	1.45104676850955
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	15/506	196/9376	1.41808502056949	PLCG2/IL6ST/PIK3R1/ITPR2/JAK2/MAP1LC3B/TCF7L2/VEGFA/HIF1A/IFNAR1/MAP1LC3C/MAPK14/PIK3CA/IRF3/ATG14	1.41276650390259
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	14/506	181/9376	1.43323215338589	TGFB2/CD74/HLA-DRA/CTSD/JAK2/CD14/IFNGR2/BCL2/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/MAPK14/HLA-DQA1	1.40566939335064
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	16/506	214/9376	1.38539396402054	PLCG2/CFL2/PIK3R1/SAMHD1/ITPR2/GNAI1/WEE1/BCL2/BCL2L1/MAPK14/FBXW11/PIK3CA/PXN/RIPK1/PAK2/IRF3	1.36212115562887
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/506	136/9376	1.49872122762148	PIK3R1/CCND2/BCL2/IFNAR1/BCL2L1/CD46/PIK3CA/CDKN1B/IRF3/STAT5B/CDK2	1.39923419241284
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/506	77/9376	1.68451311534315	PIK3R1/ARHGEF6/TGFB2/TGFBR1/VEGFA/BCL2L1/PIK3CA	1.44048287340877
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/506	122/9376	1.51882330071924	PLCG2/ACTB/PIK3R1/ACTG1/PFKP/HIF1A/PIK3CA/NCOA1/KAT2B/THRB	1.37763360079681
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/506	138/9376	1.47700063011972	ITPR2/YWHAE/IGF1R/ADCY3/SMC3/PPP2R5E/SLK/MAPK14/FBXW11/YWHAZ/CDK2	1.34824433354689
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/506	138/9376	1.47700063011972	PIK3R1/IRS1/SOCS2/IRS2/FLOT1/TRIP10/EIF4EBP1/SOCS1/PIK3CA/FLOT2/PRKAA1	1.34824433354689
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/506	93/9376	1.59394789408815	CST3/KCNMA1/ITPR2/PRKG1/SLC4A2/VAMP2/ADCY3/LYZ	1.3748164900507
NA	NA	hsa04081	Hormone signaling	16/506	219/9376	1.35376396484199	PRLR/PIK3R1/IGF2/IRS1/SSTR1/SLC40A1/IRS2/JAK2/IGF1R/PRKG1/GNAI1/VIPR2/ADCY3/PIK3CA/STAT5B/THRB	1.26519693075189
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/506	158/9376	1.40731475459048	CDKN1C/CCND2/TGFB2/YWHAE/RAD21/WEE1/SMC3/PPP2R5E/STAG1/CDKN1B/YWHAZ/CDK2	1.2332167662499
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/506	52/9376	1.78169656430526	LPL/LRP1/SORT1/LRPAP1/LDLR	1.35001262289734
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	11/506	143/9376	1.42535725144421	ACTN4/C7/HLA-DRA/C1QA/HLA-DRB1/C1QB/HLA-DQB1/HLA-DPB1/HLA-DPA1/ACTN1/HLA-DQA1	1.2241919762479
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/506	82/9376	1.58179890099296	CD74/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DPA1/HLA-DQA1	1.26379774280906
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/506	83/9376	1.56274108290871	SAMHD1/POLR2L/CCL4L2/RIPK1/IFI16/IRF3/GSDMD	1.22989712496394
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/506	99/9376	1.49734499141614	PLCG2/PIK3R1/IL1R1/ITPR2/PTGER2/ADCY3/MAPK14/PIK3CA	1.18814830935834
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/506	99/9376	1.49734499141614	PIK3R1/PDGFD/PDGFRA/PDGFRB/HIF1A/WASF2/EIF4EBP1/PIK3CA	1.18814830935834
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/506	69/9376	1.61127341467606	KCNMA1/ITPR2/PDE3A/GNAI1/PTGER2/PDE1C	1.21717852983802
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/506	115/9376	1.45014607320846	PIK3R1/ITPR2/JAK2/CREB3L1/GNAI1/BCL2/ADCY3/ATF4/PIK3CA	1.16003884107882
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/506	148/9376	1.37720329024677	WNT2/PIK3R1/JAG1/FGF10/PTEN/IGF1R/TCF7L2/FGFR1/PIK3CA/NCOA1/FZD6	1.10471849206723
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/506	86/9376	1.50822685908631	PLCG2/PIK3R1/EIF4EBP1/PIK3CA/CDKN1B/PAK2/STAT5B	1.13083194522735
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/506	56/9376	1.65443252399774	CCND2/BCL2/CDON/FBXW11/SCUBE2	1.17314047495497
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/506	71/9376	1.56588543116406	PLCG2/TJP1/MAPK14/ATP6V1B2/PTPN11/JAM3	1.14313779909852
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/506	87/9376	1.49089091817727	TPM4/TPM1/SLC8A1/TNNI3/TPM2/ASPH/TNNT2	1.09864966847417
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/506	87/9376	1.49089091817727	PIK3R1/TGFB2/TGFBR1/TCF7L2/BCL2/BCL2L11/PIK3CA	1.09864966847417
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/506	42/9376	1.76472802559759	INMT/CYP1A2/DLST/HAAO	1.18630630893799
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/506	73/9376	1.52298446044724	SAMHD1/SERINC3/FURIN/VPS4B/KAT2B/MDFIC	1.0713658303202
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/506	73/9376	1.52298446044724	PLCG2/PIK3R1/EML4/HGF/PIK3CA/STAT5B	1.0713658303202
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/506	235/9376	1.26159280127828	ACTB/MT-ND3/MT-ATP8/ACTG1/MT-ND4L/PRKG1/CREB3L1/ADCY3/FGFR1/MAPK14/PNPLA2/NDUFB10/SMARCC1/NDUFA3/SMARCD3/PRKAA1	0.969978151300634
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	8/506	105/9376	1.41178242047807	PLCG2/IL1R1/CD14/BCL2/BCL2L1/CCL4L2/LTBR/RIPK1	1.01344048093121
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/506	105/9376	1.41178242047807	PLCG2/PIK3R1/ITPR2/RRAS/MAPK14/PIK3CA/PTPN11/RRAS2	1.01344048093121
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/506	154/9376	1.32354601919819	ACTB/MYL9/ACTG1/MAP2K5/ITPR2/GNAI1/ADCY3/ROCK1/MYLK/CAMK1D/PRKAA1	0.966903091821678
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/506	254/9376	1.24017304161091	PLCG2/PDGFD/SLC8A1/PDGFRA/PDGFRB/FGF10/ITPR2/HGF/VEGFA/CYSLTR2/ADCY3/PDE1C/FGFR1/VEGFB/ASPH/MYLK/CAMK1D	0.926819513960969
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/506	59/9376	1.57030883633684	GPX3/GPX4/PGD/ANPEP/GSTT2B	1.0495355299663
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/506	59/9376	1.57030883633684	PIK3R1/PTEN/TCF7L2/PIK3CA/ILK	1.0495355299663
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/506	75/9376	1.48237154150198	PIK3R1/BCL2/BCL2L1/TOP2B/PIK3CA/GSTT2B	1.00172052859289
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/506	75/9376	1.48237154150198	GPX3/SLC26A4/ITPR2/CREB3L1/ADCY3/ATF4	1.00172052859289
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	20/506	308/9376	1.20322365381654	MT-ND3/MT-ATP8/GPX3/MT-ND4L/DNAH10/CREB3L1/DCTN1/CLTC/POLR2L/PSMC3/WIPI2/AP2A2/TGM2/NDUFB10/REST/AP2M1/AP2A1/NDUFA3/ATG14/AP2B1	0.86614967074736
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	11/506	157/9376	1.29825533093326	PIK3R1/IRS1/IRS2/IL6R/ATF4/MAPK14/BCL2L11/PIK3CA/NDUFB10/NDUFA3/PRKAA1	0.900109240729762
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/506	275/9376	1.21284944304707	MT-ND3/MT-ATP8/PIK3R1/LAMC1/MT-ND4L/C7/ITPR2/C1QA/CYBA/CREB3L1/C1QB/ATF4/PSMC3/MAPK14/PIK3CA/NDUFB10/NDUFA3/NCF1	0.855644561983266
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/506	125/9376	1.33413438735178	PIK3R1/CTSD/PTEN/GNAI1/BCL2/PPP2R5E/ROCK1/MAPK14/PIK3CA	0.898216287582308
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/506	31/9376	1.79319138084916	GLUL/ACSS1/ACSS2	1.05649699736507
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/506	109/9376	1.35997389128622	PIK3R1/CD14/IFNAR1/CCL4L2/MAPK14/PIK3CA/RIPK1/IRF3	0.902846163514787
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/506	109/9376	1.35997389128622	PIK3R1/IRS1/IRS2/PTEN/CREB3L1/PIK3CA/PTPN11/PRKAA1	0.902846163514787
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/506	226/9376	1.22984364615761	PIK3R1/MYL9/CFTR/SSTR1/PDE3A/TNNI3/CREB3L1/GNAI1/VIPR2/PTGER2/ADCY3/RRAS/ROCK1/PIK3CA/RRAS2	0.835363050481735
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/506	62/9376	1.49432615070764	JAG1/MAML2/NCOR2/MAML3/KAT2B	0.932696615116771
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/506	78/9376	1.42535725144421	PLCG2/PTEN/IMPA2/PIK3C2A/PIK3CA/INPP5K	0.900959892410075
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/506	32/9376	1.73715415019763	ACSS1/ACSS3/ACSS2	0.997621903795208
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/506	32/9376	1.73715415019763	BCL2/BCL2L1/BCL2L11	0.997621903795208
NA	NA	hsa03272	Virion - Hepatitis viruses	4/506	48/9376	1.54413702239789	TGOLN2/CLDN23/VPS4B/LDLR	0.902679775967367
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	23/506	368/9376	1.15810276679842	ACTB/MT-ND3/MT-ATP8/GPX3/ACTG1/MT-ND4L/DNAH10/MAP1LC3B/ANXA11/BCL2/OPTN/BCL2L1/DCTN1/MAP1LC3C/ATF4/PSMC3/WIPI2/MAPK14/NDUFB10/SQSTM1/PINK1/NDUFA3/ATG14	0.739006532586614
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/506	33/9376	1.68451311534315	SNAP23/VAMP2/STX2	0.940794253254281
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/506	49/9376	1.51262402194079	CREB3L1/GNAI1/RGS9/ATF4	0.859260983124598
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/506	65/9376	1.42535725144421	ITPR2/CREB3L1/ADCY3/ATF4/LDLR	0.821885734996347
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/506	19/9376	1.95048887039734	DLST/OGDH	0.990500293058617
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/506	98/9376	1.32354601919819	PLCG2/PIK3R1/ITPR2/PTEN/IMPA2/PIK3C2A/PIK3CA	0.768990547124882
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/506	115/9376	1.28901873174085	AKAP13/ITPR2/CREB3L1/GNAI1/BCL2/ADCY3/ATF4/FGFR1	0.744809239874157
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/506	201/9376	1.1984347039506	PROM1/CCND2/IGFBP3/IGF1R/CD14/MAF/BCL2L1/JUP/CDK14/TAF15/HOXA10/CDKN1B/MEIS1	0.679221940988242
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/506	168/9376	1.21325051759834	GLUL/JAK2/CAPN2/IFNGR2/BCL2/STAT6/IFNAR1/VPS4B/RIPK1/SQSTM1/STAT5B	0.666133333178785
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/506	36/9376	1.54413702239789	GALNT15/GALNT1/GALNT7	0.781241265302552
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/506	119/9376	1.24569037101006	PIK3R1/JAG1/CREB3L1/IL18R1/ATF4/MAPK14/PIK3CA/RIPK1	0.644207195926347
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/506	37/9376	1.50240358936011	LAMA4/HBA2/HBA1	0.731311654423879
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/506	37/9376	1.50240358936011	TCF7L2/CCDC6/NCOA4	0.731311654423879
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/506	70/9376	1.32354601919819	IRS1/IRS2/JAK2/PTPN11/PRKAA1	0.648937159362399
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/506	104/9376	1.24718759501368	PLA2G2A/LPCAT2/LPIN1/AGPAT4/GDPD5/GPD1L/LPGAT1	0.605418540795358
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	10/506	156/9376	1.18779770953684	PIK3R1/YWHAE/IFNAR1/CLDN23/PIK3CA/RIPK1/YWHAZ/IRF3/CDK2/LDLR	0.564919045269139
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/506	38/9376	1.462866652798	NNMT/ENPP1/NT5C	0.682841398925459
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/506	38/9376	1.462866652798	PIK3R1/IRS1/PIK3CA	0.682841398925459
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/506	23/9376	1.61127341467606	GLUL/GLS	0.70100811510187
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/506	23/9376	1.61127341467606	CTSA/ANPEP	0.70100811510187
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/506	195/9376	1.14028580115537	PLCG2/ACTB/PIK3R1/ACTG1/CYBA/HDAC9/MAPK14/PIK3CA/CASP4/HDAC5/NCF1/GSDMD	0.472808325637862
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/506	144/9376	1.15810276679842	C1QA/CD14/LPIN1/TCF7L2/C1QB/MAPK14/RIPK1/IRF3/PRKAA1	0.456637848274176
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/506	110/9376	1.17915918074021	PIK3R1/IGF1R/GNAI1/ADCY3/MAPK14/PIK3CA/CDK2	0.451427850650842
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/506	93/9376	1.19546092056611	MMP2/ITPR2/ADCY3/ATF4/MAPK14/MAP3K3	0.452435136868922
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/506	60/9376	1.23530961791831	ITPR2/IGF1R/PRKG1/GNAI1	0.436716550176986
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/506	238/9376	1.08997907463381	PLCG2/IL6ST/PIK3R1/NRP1/C7/C1QA/CFD/IFNAR1/RPS21/C1QB/IL6R/MAPK14/PIK3CA/IRF3	0.335817644325736
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/506	10/9376	1.85296442687747	PAPSS2	0.64454453309578
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/506	98/9376	1.13446801645559	ITPR2/CREB3L1/ADCY3/ATF4/CAMK1D/LDLR	0.319597916244622
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/506	116/9376	1.11816818863296	ACSS1/PFKP/PGD/DLST/ACSS2/ME3/OGDH	0.305860339588289
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/506	45/9376	1.23530961791831	ABCA8/CFTR/ABCC9	0.377903511596453
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/506	101/9376	1.10077094665988	WNT2/CREB3L1/GNAI1/TCF7L2/ADCY3/FZD6	0.243185766774929
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/506	65/9376	1.14028580115537	LPL/LPIN1/AGPAT4/PNPLA2	0.271063672714306
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/506	29/9376	1.27790650129481	YAP1/AJUBA	0.357981572157612
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/506	47/9376	1.18274325119839	ACSS1/ACSS2/ME3	0.299965851122892
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/506	193/9376	1.05609371480063	PLCG2/PIK3R1/JAK2/GNAI1/ADCY3/CCL4L2/ROCK1/PIK3CA/PXN/STAT5B/NCF1	0.188061394060244
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/506	102/9376	1.08997907463381	CFTR/PLA2G2A/KCNMA1/ITPR2/SLC4A2/ADCY3	0.218226330125676
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/506	66/9376	1.1230087435621	COMT/HSD17B6/CYP1A2/HSD17B11	0.239514712973934
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	14/506	250/9376	1.03766007905138	PSAP/CTSD/TPP1/CLTC/CTSA/BLOC1S1/SORT1/AP2A2/VPS13C/VPS41/ATP6V1B2/AP2M1/AP2A1/AP2B1	0.144148486263122
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/506	48/9376	1.15810276679842	PIK3R1/PIK3CA/SLC37A4	0.262279838053472
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/506	12/9376	1.54413702239789	CD46	0.450471461953732
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/506	30/9376	1.23530961791831	DLST/OGDH	0.308309214222383
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/506	30/9376	1.23530961791831	PLA2G2A/CYP1A2	0.308309214222383
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/506	178/9376	1.04099125105476	WNT2/CCND2/RSPO2/TCF7L2/TBL1XR1/NKD1/MCC/FBXW11/CTNND2/FZD6	0.1318722932014
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/506	49/9376	1.13446801645559	GALNT15/GALNT1/GALNT7	0.225395445927412
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/506	86/9376	1.07730489934737	KCNMA1/CREB3L1/VAMP2/ADCY3/ATF4	0.17200753589007
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	12/506	216/9376	1.02942468159859	PIK3R1/JAK2/CYBA/CD14/BCL2/BCL2L1/ATF4/MAPK14/PIK3CA/IRF3/NCF1/LDLR	0.104493673586336
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/506	31/9376	1.19546092056611	PFKP/PGD	0.26034558703756
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/506	69/9376	1.07418227645071	PLCG2/PIK3R1/MAPK14/PIK3CA	0.147713072452463
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/506	51/9376	1.08997907463381	PLA2G2A/LPCAT2/PAFAH1B2	0.153886767462131
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/506	89/9376	1.04099125105476	GLUL/TRAK2/GNAI1/ADCY3/GLS	0.0927999068866117
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/506	52/9376	1.06901793858316	IGF1R/ADCY3/LDLR	0.119195980318046
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/506	33/9376	1.1230087435621	DLST/OGDH	0.169063114276841
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/506	14/9376	1.32354601919819	B3GNT2	0.28934424378132
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/506	128/9376	1.01333992094862	ENPP1/PDE3A/ADCY3/PDE1C/GMPR/PAPSS2/NT5C	0.0362938815054095
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/506	34/9376	1.08997907463381	FBXW11/PRKAA1	0.125533644136868
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/506	149/9376	0.994880229195957	MT-ND3/MT-ND4L/ITPR2/GNAI1/ADCY3/MAPK14/NDUFB10/NDUFA3	-0.0150457028394799
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/506	133/9376	0.975244435198669	PLCG2/PIK3R1/IFNGR2/IFNAR1/TYROBP/PIK3CA/PTPN11	-0.0686738301387618
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/506	133/9376	0.975244435198669	ITPR2/COMT/CREB3L1/GNAI1/ATF4/PPP2R5E/MAPK14	-0.0686738301387618
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/506	36/9376	1.02942468159859	ENPP1/GYG2	0.0422462992536488
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/506	37/9376	1.00160239290674	GLUL/GLS	0.00233248454526003
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/506	17/9376	1.08997907463381	GLUL	0.0886850359113431
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	20/506	388/9376	0.95513630251416	MT-ND3/WNT2/MT-ATP8/PIK3R1/IRS1/MT-ND4L/IRS2/LPL/ITPR2/CAPN2/LRP1/ATF4/PSMC3/WIPI2/RTN3/PIK3CA/NDUFB10/FZD6/NDUFA3/ATG14	-0.215565115510503
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/506	138/9376	0.939909491894369	MT-ND3/MT-ATP8/MT-ND4L/ATP6V1B2/NDUFB10/PPA1/NDUFA3	-0.169846079727475
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/506	59/9376	0.942185301802104	ENPP1/NT5C/UCKL1	-0.106396001686939
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/506	100/9376	0.926482213438735	IL6ST/IL18R1/IL6R/CCL4L2/LTBR	-0.176526999649265
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/506	298/9376	0.93270021487121	IL6ST/PRLR/TGFB2/IL1RL1/TGFBR1/IL1R1/LIFR/IFNGR2/IFNAR1/IL18R1/IL6R/CCL4L2/OSMR/LTBR/IL16	-0.281984870295426
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/506	122/9376	0.911293980431543	PIK3R1/PPP2R5E/MAPK14/PIK3CA/PTPN11/PAK2	-0.235541451166583
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/506	144/9376	0.90074659639877	PIK3R1/ITPR2/PSMC3/WIPI2/KAT5/PIK3CA/ATG14	-0.286667093638789
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/506	63/9376	0.882364012798795	EZH1/NSD1/DLST	-0.223750884811905
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/506	63/9376	0.882364012798795	PLA2G2A/GPX4/PTGES	-0.223750884811905
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/506	63/9376	0.882364012798795	WNT2/TCF7L2/FZD6	-0.223750884811905
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/506	20/9376	0.926482213438735	CYB5R3	-0.0786070324109383
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/506	85/9376	0.871983259707045	ENPP1/GMPR/NT5C/UCKL1	-0.283167941712052
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	24/506	480/9376	0.926482213438735	MT-ND3/WNT2/MT-ATP8/GPX3/MT-ND4L/DNAH10/ITPR2/CAPN2/MAP1LC3B/BCL2/OPTN/BCL2L1/DCTN1/MAP1LC3C/ATF4/PSMC3/WIPI2/MAPK14/NDUFB10/SQSTM1/PINK1/FZD6/NDUFA3/ATG14	-0.394925104116312
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/506	21/9376	0.882364012798795	DSEL	-0.128892319624526
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/506	21/9376	0.882364012798795	ENPP1	-0.128892319624526
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/506	65/9376	0.855214350866525	PIK3R1/ITPR2/PIK3CA	-0.279758389567734
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/506	107/9376	0.865871227512837	ITPR2/PFKP/CREB3L1/ATF4/PRKAA1	-0.333270201844893
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/506	44/9376	0.842256557671577	CHST9/MGAT4B	-0.25048941229171
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/506	44/9376	0.842256557671577	PARP4/PARG	-0.25048941229171
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/506	67/9376	0.829685564273494	ACSS1/PFKP/ACSS2	-0.334146127931655
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/506	23/9376	0.80563670733803	GLS	-0.22289574871527
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/506	90/9376	0.823539745278876	CFTR/SLC4A2/ADCY3/LDLR	-0.401747241581128
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/506	91/9376	0.814489857968119	PLCG2/PIK3R1/CD79B/PIK3CA	-0.424713911716443
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/506	91/9376	0.814489857968119	PDE3A/GNAI1/ADCY3/PDE1C	-0.424713911716443
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/506	72/9376	0.772068511198946	MAPK14/RIPK1/IRF3	-0.463697560715754
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/506	116/9376	0.798691563309255	GLUL/ITPR2/GNAI1/ADCY3/GLS	-0.521056195584663
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/506	26/9376	0.712678625722104	PLA2G2A	-0.35038692384341
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/506	26/9376	0.712678625722104	SLC19A3	-0.35038692384341
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/506	75/9376	0.741185770750988	GLUL/PFKP/MAT2B	-0.537468536645874
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/506	76/9376	0.731433326399001	LPL/ILK/ME3	-0.561457036079336
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/506	28/9376	0.661773009599096	B3GNT2	-0.428082044078814
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/506	28/9376	0.661773009599096	MOCOS	-0.428082044078814
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/506	28/9376	0.661773009599096	ATP6V1B2	-0.428082044078814
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/506	29/9376	0.638953250647404	RGS9	-0.465077579522077
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/506	103/9376	0.719597835680571	PPP2R5E/ACIN1/UPF2/GSPT1	-0.683421961590194
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/506	31/9376	0.597730460283055	UBL4A	-0.535805823289954
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/506	32/9376	0.579051383399209	PFKP	-0.569687575089489
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/506	32/9376	0.579051383399209	WIPI2	-0.569687575089489
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/506	34/9376	0.544989537316903	POLR2L	-0.634804500195994
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/506	35/9376	0.529418407679277	PFKP	-0.666148965470482
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	11/506	268/9376	0.760545100584036	MT-ND3/MT-ATP8/MT-ND4L/ITPR2/GNAI1/BCL2L1/ATF4/PSMC3/NDUFB10/PINK1/NDUFA3	-0.949901777151763
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/506	36/9376	0.514712340799297	RNASEH2C	-0.696748666795254
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/506	37/9376	0.50080119645337	COMT	-0.726646685333359
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/506	37/9376	0.50080119645337	UXS1	-0.726646685333359
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/506	38/9376	0.487622217599334	UXS1	-0.755882411484677
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/506	67/9376	0.553123709515663	ITPR2/ATF4	-0.876742957770101
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/506	39/9376	0.475119083814736	MAT2B	-0.784491953903198
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/506	142/9376	0.652452262985025	HERC2/SOCS1/UBE2Q1/TRIP12/FBXW11	-0.996696168672654
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/506	68/9376	0.544989537316903	HSD17B6/CYP1A2	-0.899387275420238
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/506	94/9376	0.591371625599193	S100A8/MAPK14/S100A9	-0.950978616102671
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/506	69/9376	0.537091138225354	CREB3L1/ATF4	-0.921752384933092
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/506	70/9376	0.529418407679277	CYP1A2/GSTT2B	-0.943846821313479
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/506	97/9376	0.573081781508496	PRKG1/GNAI1/ADCY3	-1.00943661784467
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/506	43/9376	0.430921959738947	PLA2G2A	-0.893294188966286
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/506	73/9376	0.507661486815745	CYP1A2/GSTT2B	-1.00858572265261
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/506	44/9376	0.421128278835789	TAF15	-0.919221966291445
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/506	46/9376	0.402818353669015	PSMC3	-0.969713925718237
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/506	79/9376	0.469104918196828	CYP1A2/GSTT2B	-1.13174847752783
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/506	108/9376	0.514712340799297	ACIN1/UPF2/THOC7	-1.21148265121509
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/506	82/9376	0.451942543140846	GSTT2B/UCKL1	-1.19050375606785
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/506	54/9376	0.343141560532865	MAT2B	-1.15614738577822
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/506	55/9376	0.336902623068631	PSAP	-1.17794899887084
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/506	243/9376	0.610029440947315	HNRNPU/SF3B5/ACIN1/RBM17/THOC7/DDX42/WBP11/SYF2	-1.47104959824884
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/506	56/9376	0.330886504799548	MGAT4B	-1.19945769009632
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/506	56/9376	0.330886504799548	CD14	-1.19945769009632
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/506	63/9376	0.294121337599598	POLR2L	-1.34262464267666
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/506	191/9376	0.485069221695673	HDAC9/CREB3L1/GNAI1/ATF4/HDAC5	-1.71721645399683
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/506	174/9376	0.425968833764936	CAPN2/BCL2/AMFR/ATF4	-1.82544212706791
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/506	78/9376	0.237559541907368	PFKP	-1.61494431036478
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/506	115/9376	0.322254682935212	ITPR2/GNAI1	-1.74656836735385
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/506	154/9376	0.360967096144962	HSD17B6/MAT2B/HAAO	-1.90972181343615
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/506	86/9376	0.215460979869473	PDE1C	-1.74564128278448
NA	NA	hsa04082	Neuroactive ligand signaling	4/506	199/9376	0.372455161181401	GNAI1/SLC6A2/ADCY3/OGFRL1	-2.13707626615208
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/506	370/9376	0.50080119645337	PRLR/NR3C1/SSTR1/VIPR2/NPW/LYPD6/CYSLTR2/PTGER2/OGFRL1/THRB	-2.3399550414472
Genetic Information Processing	Translation	hsa03010	Ribosome	2/506	222/9376	0.166933732151123	MRPS6/RPS21	-3.00019628842002
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/506	449/9376	0.165074781904452	SLC8A1/PRKG1/ADCY3/PDE1C	-4.33029086179785