ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003779 actin binding 69/921 443/18639 0.155756207674944 3.1521606458776 1.43844540002901e-17 1.49454477063014e-14 GO:0051015 actin filament binding 41/921 209/18639 0.196172248803828 3.97009179745336 2.47083083351282e-14 1.28359661800991e-11 GO:0045296 cadherin binding 50/921 334/18639 0.149700598802395 3.02960853537225 2.15261528854314e-12 7.4552242826544e-10 GO:0005201 extracellular matrix structural constituent 31/921 168/18639 0.18452380952381 3.73435318752908 1.83326756957563e-10 4.76191251197269e-08 GO:0140297 DNA-binding transcription factor binding 57/921 488/18639 0.116803278688525 2.36383964329578 1.4136154272414e-09 2.93749285780764e-07 GO:0019838 growth factor binding 26/921 136/18639 0.191176470588235 3.86898831193715 2.44162321794206e-09 4.22807753906966e-07 GO:0008201 heparin binding 28/921 172/18639 0.162790697674419 3.2945231421862 2.47802879204087e-08 3.67810273561495e-06 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 43/921 349/18639 0.123209169054441 2.4934806753591 3.26480637466683e-08 4.24016727909854e-06 GO:0042805 actinin binding 12/921 37/18639 0.324324324324324 6.5636059512281 1.16183787061523e-07 1.34127727507692e-05 GO:1901681 sulfur compound binding 35/921 275/18639 0.127272727272727 2.57571809298194 2.8233107018003e-07 2.93341981917052e-05 GO:0008307 structural constituent of muscle 12/921 42/18639 0.285714285714286 5.78222429036761 5.51680922592325e-07 5.21087707794023e-05 GO:0098631 cell adhesion mediator activity 16/921 76/18639 0.210526315789474 4.26058631921824 7.36053757168767e-07 6.37299878081957e-05 GO:0005178 integrin binding 24/921 161/18639 0.149068322981366 3.01681267323528 1.27304423775168e-06 0.000101745612540308 GO:0051371 muscle alpha-actinin binding 7/921 15/18639 0.466666666666667 9.4442996742671 3.19089930210023e-06 0.000216017773432575 GO:0002020 protease binding 21/921 136/18639 0.154411764705882 3.12495209810309 3.2688246754488e-06 0.000216017773432575 GO:0005539 glycosaminoglycan binding 30/921 242/18639 0.12396694214876 2.50881632433306 3.4041757674734e-06 0.000216017773432575 GO:0023026 MHC class II protein complex binding 9/921 27/18639 0.333333333333333 6.74592833876221 3.53445827560517e-06 0.000216017773432575 GO:0050840 extracellular matrix binding 14/921 67/18639 0.208955223880597 4.22879089892557 3.96158357423357e-06 0.000228671407423815 GO:0051393 alpha-actinin binding 9/921 28/18639 0.321428571428571 6.50500232666356 4.98103448381312e-06 0.000272383938351676 GO:0097493 structural molecule activity conferring elasticity 6/921 11/18639 0.545454545454545 11.0387918270654 5.34212858694959e-06 0.000277523580092031 GO:0003712 transcription coregulator activity 48/921 495/18639 0.096969696969697 1.96245188036719 6.63063701013755e-06 0.000328058659692044 GO:0019955 cytokine binding 21/921 144/18639 0.145833333333333 2.95134364820847 8.21253324662723e-06 0.000387855547420259 GO:0005518 collagen binding 14/921 72/18639 0.194444444444444 3.93512486427796 9.61133349878635e-06 0.000434181543706044 GO:0017166 vinculin binding 6/921 12/18639 0.5 10.1188925081433 1.02365318101864e-05 0.000439356382515934 GO:0003713 transcription coactivator activity 30/921 256/18639 0.1171875 2.37161543159609 1.05716165186702e-05 0.000439356382515934 GO:0044325 transmembrane transporter binding 20/921 136/18639 0.147058823529412 2.97614485533627 1.17959758294659e-05 0.000465321950787159 GO:0098632 cell-cell adhesion mediator activity 12/921 55/18639 0.218181818181818 4.41551673082618 1.20921007423034e-05 0.000465321950787159 GO:0046332 SMAD binding 14/921 79/18639 0.177215189873418 3.58644291427865 2.90161775511509e-05 0.00107670744555878 GO:0016922 nuclear receptor binding 19/921 137/18639 0.138686131386861 2.80670011174778 4.45976484890774e-05 0.00159782609586729 GO:0032395 MHC class II receptor activity 5/921 10/18639 0.5 10.1188925081433 5.96332817682442e-05 0.00201323836309904 GO:0023023 MHC protein complex binding 9/921 37/18639 0.243243243243243 4.92270446342108 6.00677471184506e-05 0.00201323836309904 GO:0001968 fibronectin binding 8/921 30/18639 0.266666666666667 5.39674267100977 7.62910871087417e-05 0.00247707623456196 GO:0005158 insulin receptor binding 7/921 23/18639 0.304347826086957 6.15932587452202 8.58280656673796e-05 0.00270228364328507 GO:0005516 calmodulin binding 24/921 207/18639 0.115942028985507 2.34640985696077 9.29401801187196e-05 0.0028401425630397 GO:0005200 structural constituent of cytoskeleton 16/921 112/18639 0.142857142857143 2.89111214518381 0.000122393181459257 0.0036333290153191 GO:0042974 nuclear retinoic acid receptor binding 7/921 25/18639 0.28 5.66657980456026 0.000154315151627659 0.00445370673725383 GO:0035615 clathrin adaptor activity 6/921 18/18639 0.333333333333333 6.74592833876221 0.000159210735587653 0.00447080957501545 GO:0001223 transcription coactivator binding 9/921 44/18639 0.204545454545455 4.13954693514954 0.000250885679320216 0.00685974265299222 GO:0005161 platelet-derived growth factor receptor binding 5/921 14/18639 0.357142857142857 7.22778036295952 0.000401302747805865 0.0104461062031109 GO:0140312 cargo adaptor activity 6/921 21/18639 0.285714285714286 5.78222429036761 0.000409700600984984 0.0104461062031109 GO:0019199 transmembrane receptor protein kinase activity 12/921 78/18639 0.153846153846154 3.11350538712102 0.000421598589362336 0.0104461062031109 GO:0043495 protein-membrane adaptor activity 9/921 47/18639 0.191489361702128 3.87532053503361 0.000422268008210451 0.0104461062031109 GO:0001221 transcription coregulator binding 15/921 115/18639 0.130434782608696 2.63971108908087 0.000537732307510966 0.012993113197765 GO:0042277 peptide binding 25/921 249/18639 0.100401606425703 2.0319061261332 0.000626928064838264 0.014804051349249 GO:0140375 immune receptor activity 18/921 156/18639 0.115384615384615 2.33512904034077 0.000710684589432486 0.0164089175204523 GO:0005159 insulin-like growth factor receptor binding 5/921 16/18639 0.3125 6.32430781758958 0.000806102348676668 0.0182073987016317 GO:0004896 cytokine receptor activity 13/921 96/18639 0.135416666666667 2.74053338762215 0.000866012223090077 0.0191443978678849 GO:0019894 kinesin binding 8/921 42/18639 0.19047619047619 3.85481619357841 0.000909477105344189 0.0196863898427628 GO:0005096 GTPase activator activity 26/921 271/18639 0.0959409594095941 1.94163251078765 0.000971498969334512 0.0205997434518073 GO:0003714 transcription corepressor activity 21/921 204/18639 0.102941176470588 2.08330139873539 0.00120401099470121 0.0250193484698911 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/921 44/18639 0.181818181818182 3.67959727568848 0.00125162845554899 0.0254988620650078 GO:0005160 transforming growth factor beta receptor binding 6/921 26/18639 0.230769230769231 4.67025808068153 0.00140685610487131 0.0274239940208412 GO:0050681 nuclear androgen receptor binding 6/921 26/18639 0.230769230769231 4.67025808068153 0.00140685610487131 0.0274239940208412 GO:0002162 dystroglycan binding 4/921 11/18639 0.363636363636364 7.35919455137696 0.001478097849054 0.0274239940208412 GO:0048185 activin binding 4/921 11/18639 0.363636363636364 7.35919455137696 0.001478097849054 0.0274239940208412 GO:0048407 platelet-derived growth factor binding 4/921 11/18639 0.363636363636364 7.35919455137696 0.001478097849054 0.0274239940208412 GO:0043394 proteoglycan binding 7/921 37/18639 0.189189189189189 3.82877013821639 0.00197045147381373 0.035917527741973 GO:0019903 protein phosphatase binding 16/921 144/18639 0.111111111111111 2.24864277958741 0.00203809288791762 0.0365099743197657 GO:0001540 amyloid-beta binding 11/921 83/18639 0.132530120481928 2.68211608649582 0.00251312861581164 0.0442566208784456 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/921 60/18639 0.15 3.035667752443 0.00258384432631832 0.0447435709174122 GO:0019902 phosphatase binding 19/921 190/18639 0.1 2.02377850162866 0.00279989278079268 0.0476899770367803 GO:0019855 calcium channel inhibitor activity 4/921 13/18639 0.307692307692308 6.22701077424205 0.00295847377421779 0.0487913373240045 GO:0043560 insulin receptor substrate binding 4/921 13/18639 0.307692307692308 6.22701077424205 0.00295847377421779 0.0487913373240045 GO:0070325 lipoprotein particle receptor binding 6/921 31/18639 0.193548387096774 3.91699064831354 0.0036454603500969 0.0591817703711044 GO:0005080 protein kinase C binding 8/921 52/18639 0.153846153846154 3.11350538712102 0.00375446671112147 0.0600137063516185 GO:0004713 protein tyrosine kinase activity 15/921 140/18639 0.107142857142857 2.16833410888785 0.00392665024362949 0.0618149939868339 GO:0035591 signaling adaptor activity 14/921 129/18639 0.108527131782946 2.19634876145747 0.00466614545909182 0.0723600765969613 GO:0005543 phospholipid binding 38/921 497/18639 0.0764587525150905 1.54735579601387 0.00521911987460607 0.0797450816134663 GO:0050431 transforming growth factor beta binding 5/921 24/18639 0.208333333333333 4.21620521172638 0.00564812813878008 0.0850493497998914 GO:0051219 phosphoprotein binding 11/921 93/18639 0.118279569892473 2.39371650730272 0.00608387738645109 0.0903021229217526 GO:0030276 clathrin binding 7/921 46/18639 0.152173913043478 3.07966293726101 0.00697520576243934 0.102073785734852 GO:0097110 scaffold protein binding 9/921 70/18639 0.128571428571429 2.60200093066543 0.00734064417828798 0.10592957362835 GO:0035091 phosphatidylinositol binding 24/921 284/18639 0.0845070422535211 1.71023535348901 0.00751132603446373 0.106907777394628 GO:0034237 protein kinase A regulatory subunit binding 5/921 26/18639 0.192307692307692 3.89188173390128 0.00805677488568799 0.110144593503024 GO:0043548 phosphatidylinositol 3-kinase binding 5/921 26/18639 0.192307692307692 3.89188173390128 0.00805677488568799 0.110144593503024 GO:0050750 low-density lipoprotein particle receptor binding 5/921 26/18639 0.192307692307692 3.89188173390128 0.00805677488568799 0.110144593503024 GO:0001786 phosphatidylserine binding 8/921 59/18639 0.135593220338983 2.74410644288632 0.0081769790023898 0.110336119266013 GO:0046965 nuclear retinoid X receptor binding 4/921 17/18639 0.235294117647059 4.76183176853803 0.00841137638051635 0.112043846914827 GO:0003774 cytoskeletal motor activity 15/921 153/18639 0.0980392156862745 1.98409657022418 0.00884061826829066 0.116270916212076 GO:0098531 ligand-modulated transcription factor activity 8/921 60/18639 0.133333333333333 2.69837133550489 0.00903746126024696 0.117374028117457 GO:0000146 microfilament motor activity 6/921 38/18639 0.157894736842105 3.19543973941368 0.0102012772962615 0.130853421121182 GO:0098641 cadherin binding involved in cell-cell adhesion 4/921 18/18639 0.222222222222222 4.49728555917481 0.0103986072626023 0.131669898476671 GO:0001217 DNA-binding transcription repressor activity 23/921 278/18639 0.0827338129496403 1.67434912005249 0.0111072194716834 0.131669898476671 GO:0008190 eukaryotic initiation factor 4E binding 3/921 10/18639 0.3 6.07133550488599 0.011112137767006 0.131669898476671 GO:0043121 neurotrophin binding 3/921 10/18639 0.3 6.07133550488599 0.011112137767006 0.131669898476671 GO:0070513 death domain binding 3/921 10/18639 0.3 6.07133550488599 0.011112137767006 0.131669898476671 GO:0033218 amide binding 21/921 247/18639 0.0850202429149798 1.72062139814583 0.0111303194380881 0.131669898476671 GO:0030695 GTPase regulator activity 36/921 489/18639 0.0736196319018405 1.48989828340761 0.0113118033033766 0.131669898476671 GO:0017124 SH3 domain binding 12/921 115/18639 0.104347826086957 2.11176887126469 0.0113979436895918 0.131669898476671 GO:0019003 GDP binding 9/921 75/18639 0.12 2.4285342019544 0.0114054772501447 0.131669898476671 GO:0060589 nucleoside-triphosphatase regulator activity 36/921 490/18639 0.073469387755102 1.48685767466596 0.0116504622796592 0.133020113280944 GO:0005021 vascular endothelial growth factor receptor activity 7/921 51/18639 0.137254901960784 2.77773519831385 0.0122039560306728 0.137825112129011 GO:0017022 myosin binding 9/921 76/18639 0.118421052631579 2.39657980456026 0.0123880170031748 0.138399458777405 GO:0016417 S-acyltransferase activity 5/921 29/18639 0.172413793103448 3.48927327867011 0.0128766648596899 0.142328242438488 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 22/921 268/18639 0.082089552238806 1.66131071029219 0.013920943411108 0.149991901401483 GO:0003953 NAD+ nucleosidase activity 3/921 11/18639 0.272727272727273 5.51939591353272 0.014724902736238 0.149991901401483 GO:0005114 type II transforming growth factor beta receptor binding 3/921 11/18639 0.272727272727273 5.51939591353272 0.014724902736238 0.149991901401483 GO:0032050 clathrin heavy chain binding 3/921 11/18639 0.272727272727273 5.51939591353272 0.014724902736238 0.149991901401483 GO:0045294 alpha-catenin binding 3/921 11/18639 0.272727272727273 5.51939591353272 0.014724902736238 0.149991901401483 GO:0050786 RAGE receptor binding 3/921 11/18639 0.272727272727273 5.51939591353272 0.014724902736238 0.149991901401483 GO:0050998 nitric-oxide synthase binding 3/921 11/18639 0.272727272727273 5.51939591353272 0.014724902736238 0.149991901401483 GO:0140031 phosphorylation-dependent protein binding 3/921 11/18639 0.272727272727273 5.51939591353272 0.014724902736238 0.149991901401483 GO:0048306 calcium-dependent protein binding 9/921 80/18639 0.1125 2.27675081433225 0.0169562015339668 0.171043625182442 GO:0051010 microtubule plus-end binding 4/921 21/18639 0.19047619047619 3.85481619357841 0.018088768528407 0.180375172104117 GO:0001618 virus receptor activity 9/921 81/18639 0.111111111111111 2.24864277958741 0.0182684404154652 0.180375172104117 GO:0003777 microtubule motor activity 8/921 68/18639 0.117647058823529 2.38091588426902 0.0185275296936999 0.180375172104117 GO:0005078 MAP-kinase scaffold activity 3/921 12/18639 0.25 5.05944625407166 0.0189229006345994 0.180375172104117 GO:0016208 AMP binding 3/921 12/18639 0.25 5.05944625407166 0.0189229006345994 0.180375172104117 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/921 12/18639 0.25 5.05944625407166 0.0189229006345994 0.180375172104117 GO:0031369 translation initiation factor binding 5/921 32/18639 0.15625 3.16215390879479 0.0193411768284137 0.182686206588381 GO:0140272 exogenous protein binding 9/921 82/18639 0.109756097560976 2.22122030666561 0.0196529315048868 0.18395852102322 GO:0070851 growth factor receptor binding 13/921 139/18639 0.0935251798561151 1.8927424835376 0.0202541226748238 0.187000999891923 GO:0016248 channel inhibitor activity 6/921 44/18639 0.136363636363636 2.75969795676636 0.0203379335782361 0.187000999891923 GO:0035173 histone kinase activity 27/921 360/18639 0.075 1.5178338762215 0.020850102927702 0.190028569665635 GO:0030296 protein tyrosine kinase activator activity 5/921 33/18639 0.151515151515152 3.06633106307373 0.0218944642264062 0.196106451131346 GO:0140311 protein sequestering activity 5/921 33/18639 0.151515151515152 3.06633106307373 0.0218944642264062 0.196106451131346 GO:0042605 peptide antigen binding 6/921 45/18639 0.133333333333333 2.69837133550489 0.0225174934935588 0.198268438472946 GO:0141110 transporter inhibitor activity 6/921 45/18639 0.133333333333333 2.69837133550489 0.0225174934935588 0.198268438472946 GO:0042826 histone deacetylase binding 12/921 127/18639 0.094488188976378 1.9122316550822 0.0233560314571326 0.200300858631949 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/921 13/18639 0.230769230769231 4.67025808068153 0.0237122286927139 0.200300858631949 GO:0017154 semaphorin receptor activity 3/921 13/18639 0.230769230769231 4.67025808068153 0.0237122286927139 0.200300858631949 GO:0031994 insulin-like growth factor I binding 3/921 13/18639 0.230769230769231 4.67025808068153 0.0237122286927139 0.200300858631949 GO:0051011 microtubule minus-end binding 3/921 13/18639 0.230769230769231 4.67025808068153 0.0237122286927139 0.200300858631949 GO:0030332 cyclin binding 5/921 34/18639 0.147058823529412 2.97614485533627 0.0246568889991456 0.204177928253616 GO:0008171 O-methyltransferase activity 4/921 23/18639 0.173913043478261 3.51961478544116 0.0247607497208427 0.204177928253616 GO:0017134 fibroblast growth factor binding 4/921 23/18639 0.173913043478261 3.51961478544116 0.0247607497208427 0.204177928253616 GO:0004879 nuclear receptor activity 7/921 59/18639 0.11864406779661 2.40109313752553 0.0256690581610177 0.206745359917034 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/921 59/18639 0.11864406779661 2.40109313752553 0.0256690581610177 0.206745359917034 GO:0045309 protein phosphorylated amino acid binding 7/921 59/18639 0.11864406779661 2.40109313752553 0.0256690581610177 0.206745359917034 GO:0061733 protein-lysine-acetyltransferase activity 6/921 47/18639 0.127659574468085 2.58354702335574 0.0273357682434319 0.218475870807121 GO:0009055 electron transfer activity 11/921 116/18639 0.0948275862068965 1.91910030326856 0.0284700374312424 0.220642491688287 GO:0035035 histone acetyltransferase binding 4/921 24/18639 0.166666666666667 3.37296416938111 0.0285832740372553 0.220642491688287 GO:0070840 dynein complex binding 4/921 24/18639 0.166666666666667 3.37296416938111 0.0285832740372553 0.220642491688287 GO:0141003 histone H2AX kinase activity 26/921 354/18639 0.0734463276836158 1.48639098989676 0.0288933724194897 0.220642491688287 GO:0032036 myosin heavy chain binding 3/921 14/18639 0.214285714285714 4.33666821777571 0.0290933795585133 0.220642491688287 GO:0044548 S100 protein binding 3/921 14/18639 0.214285714285714 4.33666821777571 0.0290933795585133 0.220642491688287 GO:0071933 Arp2/3 complex binding 3/921 14/18639 0.214285714285714 4.33666821777571 0.0290933795585133 0.220642491688287 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/921 88/18639 0.102272727272727 2.06977346757477 0.0295872697588151 0.222762125213108 GO:0140996 histone H3 kinase activity 26/921 357/18639 0.0728291316526611 1.47390030930939 0.0315961008527457 0.236175171122323 GO:0019209 kinase activator activity 13/921 148/18639 0.0878378378378378 1.77764327845761 0.0318454482767362 0.236338719710921 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/921 25/18639 0.16 3.23804560260586 0.0327366701679866 0.237855946185581 GO:0019707 protein-cysteine S-acyltransferase activity 4/921 25/18639 0.16 3.23804560260586 0.0327366701679866 0.237855946185581 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/921 25/18639 0.16 3.23804560260586 0.0327366701679866 0.237855946185581 GO:0005041 low-density lipoprotein particle receptor activity 3/921 15/18639 0.2 4.04755700325733 0.0350619546696093 0.249385546636144 GO:0005523 tropomyosin binding 3/921 15/18639 0.2 4.04755700325733 0.0350619546696093 0.249385546636144 GO:0031005 filamin binding 3/921 15/18639 0.2 4.04755700325733 0.0350619546696093 0.249385546636144 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 18/921 229/18639 0.0786026200873362 1.59074292704437 0.0354610814481682 0.249385546636144 GO:0072341 modified amino acid binding 9/921 91/18639 0.0989010989010989 2.00153917743494 0.0356824484069758 0.249385546636144 GO:0005006 epidermal growth factor receptor activity 6/921 50/18639 0.12 2.4285342019544 0.0357636635695721 0.249385546636144 GO:0008013 beta-catenin binding 10/921 106/18639 0.0943396226415094 1.90922500153648 0.0367726985812169 0.254445111092426 GO:0005112 Notch binding 4/921 26/18639 0.153846153846154 3.11350538712102 0.0372239238556773 0.254445111092426 GO:0030247 polysaccharide binding 4/921 26/18639 0.153846153846154 3.11350538712102 0.0372239238556773 0.254445111092426 GO:0042393 histone binding 19/921 247/18639 0.0769230769230769 1.55675269356051 0.0378240592094797 0.255631308882754 GO:0043531 ADP binding 5/921 38/18639 0.131578947368421 2.6628664495114 0.0378895299017749 0.255631308882754 GO:0003743 translation initiation factor activity 6/921 51/18639 0.117647058823529 2.38091588426902 0.038904957908092 0.257466568576481 GO:0005010 insulin-like growth factor receptor activity 6/921 51/18639 0.117647058823529 2.38091588426902 0.038904957908092 0.257466568576481 GO:0005030 neurotrophin receptor activity 6/921 51/18639 0.117647058823529 2.38091588426902 0.038904957908092 0.257466568576481 GO:0004674 protein serine/threonine kinase activity 30/921 433/18639 0.069284064665127 1.40215600574734 0.0395045034417938 0.259779614405214 GO:0005024 transforming growth factor beta receptor activity 3/921 16/18639 0.1875 3.79458469055375 0.0416093123543007 0.268522208298872 GO:0005521 lamin binding 3/921 16/18639 0.1875 3.79458469055375 0.0416093123543007 0.268522208298872 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/921 16/18639 0.1875 3.79458469055375 0.0416093123543007 0.268522208298872 GO:0031267 small GTPase binding 21/921 283/18639 0.0742049469964664 1.50174376445943 0.0419475918482928 0.269034246483804 GO:0030295 protein kinase activator activity 12/921 139/18639 0.0863309352517986 1.74714690788086 0.0426891224507456 0.272110418566409 GO:0031625 ubiquitin protein ligase binding 22/921 302/18639 0.0728476821192053 1.47427572966327 0.0450721468643196 0.273998377849254 GO:0034212 protein N-acetyltransferase activity 6/921 53/18639 0.113207547169811 2.29107000184377 0.0456994749524999 0.273998377849254 GO:0051018 protein kinase A binding 6/921 53/18639 0.113207547169811 2.29107000184377 0.0456994749524999 0.273998377849254 GO:0033192 calmodulin-dependent protein phosphatase activity 8/921 81/18639 0.0987654320987654 1.99879358185547 0.0464101552429424 0.273998377849254 GO:0140791 histone H2AXS140 phosphatase activity 8/921 81/18639 0.0987654320987654 1.99879358185547 0.0464101552429424 0.273998377849254 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/921 81/18639 0.0987654320987654 1.99879358185547 0.0464101552429424 0.273998377849254 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/921 81/18639 0.0987654320987654 1.99879358185547 0.0464101552429424 0.273998377849254 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/921 81/18639 0.0987654320987654 1.99879358185547 0.0464101552429424 0.273998377849254 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/921 81/18639 0.0987654320987654 1.99879358185547 0.0464101552429424 0.273998377849254 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/921 81/18639 0.0987654320987654 1.99879358185547 0.0464101552429424 0.273998377849254 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/921 81/18639 0.0987654320987654 1.99879358185547 0.0464101552429424 0.273998377849254 GO:0036408 histone H3K14 acetyltransferase activity 4/921 28/18639 0.142857142857143 2.89111214518381 0.0472047253465028 0.273998377849254 GO:0045499 chemorepellent activity 4/921 28/18639 0.142857142857143 2.89111214518381 0.0472047253465028 0.273998377849254 GO:0046966 nuclear thyroid hormone receptor binding 4/921 28/18639 0.142857142857143 2.89111214518381 0.0472047253465028 0.273998377849254 GO:0051019 mitogen-activated protein kinase binding 4/921 28/18639 0.142857142857143 2.89111214518381 0.0472047253465028 0.273998377849254 GO:0097718 disordered domain specific binding 4/921 28/18639 0.142857142857143 2.89111214518381 0.0472047253465028 0.273998377849254 GO:0019207 kinase regulator activity 21/921 287/18639 0.0731707317073171 1.48081353777707 0.0474830618356793 0.27408278470706 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/921 17/18639 0.176470588235294 3.57137382640353 0.0487231557772544 0.275126950285692 GO:0008429 phosphatidylethanolamine binding 3/921 17/18639 0.176470588235294 3.57137382640353 0.0487231557772544 0.275126950285692 GO:0008569 minus-end-directed microtubule motor activity 3/921 17/18639 0.176470588235294 3.57137382640353 0.0487231557772544 0.275126950285692 GO:0038191 neuropilin binding 3/921 17/18639 0.176470588235294 3.57137382640353 0.0487231557772544 0.275126950285692 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/921 82/18639 0.0975609756097561 1.97441805036943 0.0493028280794888 0.275406657927897 GO:0033549 MAP kinase phosphatase activity 8/921 82/18639 0.0975609756097561 1.97441805036943 0.0493028280794888 0.275406657927897 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/921 41/18639 0.121951219512195 2.46802256296179 0.0501946462147079 0.277405518175966 GO:0042169 SH2 domain binding 5/921 41/18639 0.121951219512195 2.46802256296179 0.0501946462147079 0.277405518175966 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/921 83/18639 0.0963855421686747 1.95062988108787 0.0523098818067783 0.283691224924064 GO:0008135 translation factor activity, RNA binding 8/921 83/18639 0.0963855421686747 1.95062988108787 0.0523098818067783 0.283691224924064 GO:0030165 PDZ domain binding 8/921 83/18639 0.0963855421686747 1.95062988108787 0.0523098818067783 0.283691224924064 GO:0010484 histone H3 acetyltransferase activity 4/921 29/18639 0.137931034482759 2.79141862293609 0.0526972150243929 0.283691224924064 GO:0043236 laminin binding 4/921 29/18639 0.137931034482759 2.79141862293609 0.0526972150243929 0.283691224924064 GO:0004402 histone acetyltransferase activity 5/921 42/18639 0.119047619047619 2.4092601209865 0.0547591192983159 0.290532103407318 GO:0048487 beta-tubulin binding 5/921 42/18639 0.119047619047619 2.4092601209865 0.0547591192983159 0.290532103407318 GO:0017018 myosin phosphatase activity 8/921 84/18639 0.0952380952380952 1.9274080967892 0.0554323193355511 0.290532103407318 GO:0180051 translation factor activity 8/921 84/18639 0.0952380952380952 1.9274080967892 0.0554323193355511 0.290532103407318 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/921 18/18639 0.166666666666667 3.37296416938111 0.0563880654801848 0.290532103407318 GO:0030228 lipoprotein particle receptor activity 3/921 18/18639 0.166666666666667 3.37296416938111 0.0563880654801848 0.290532103407318 GO:1990381 ubiquitin-specific protease binding 3/921 18/18639 0.166666666666667 3.37296416938111 0.0563880654801848 0.290532103407318 GO:0106310 protein serine kinase activity 25/921 361/18639 0.0692520775623269 1.40150865763758 0.0564738543595553 0.290532103407318 GO:0008017 microtubule binding 20/921 276/18639 0.072463768115942 1.46650616060048 0.0564845860329916 0.290532103407318 GO:0008083 growth factor activity 13/921 162/18639 0.0802469135802469 1.62401978525757 0.0583678519979213 0.295164696610866 GO:0043995 histone H4K5 acetyltransferase activity 4/921 30/18639 0.133333333333333 2.69837133550489 0.0585215856610572 0.295164696610866 GO:0043996 histone H4K8 acetyltransferase activity 4/921 30/18639 0.133333333333333 2.69837133550489 0.0585215856610572 0.295164696610866 GO:0043997 histone H4K12 acetyltransferase activity 4/921 30/18639 0.133333333333333 2.69837133550489 0.0585215856610572 0.295164696610866 GO:0008200 ion channel inhibitor activity 5/921 43/18639 0.116279069767442 2.35323081584728 0.0595555732266992 0.297491541262214 GO:0048156 tau protein binding 5/921 43/18639 0.116279069767442 2.35323081584728 0.0595555732266992 0.297491541262214 GO:0004601 peroxidase activity 6/921 57/18639 0.105263157894737 2.13029315960912 0.0613779763565171 0.305127834614456 GO:0016209 antioxidant activity 8/921 86/18639 0.0930232558139535 1.88258465267783 0.0620266770815652 0.306884368989268 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/921 19/18639 0.157894736842105 3.19543973941368 0.0645859809267156 0.312541879264681 GO:0005520 insulin-like growth factor binding 3/921 19/18639 0.157894736842105 3.19543973941368 0.0645859809267156 0.312541879264681 GO:0043395 heparan sulfate proteoglycan binding 3/921 19/18639 0.157894736842105 3.19543973941368 0.0645859809267156 0.312541879264681 GO:0005452 solute:inorganic anion antiporter activity 4/921 31/18639 0.129032258064516 2.6113270988757 0.0646742098574653 0.312541879264681 GO:0016411 acylglycerol O-acyltransferase activity 4/921 31/18639 0.129032258064516 2.6113270988757 0.0646742098574653 0.312541879264681 GO:0051020 GTPase binding 22/921 315/18639 0.0698412698412698 1.41343260431208 0.0652383210034783 0.313808405197287 GO:0015631 tubulin binding 26/921 385/18639 0.0675324675324675 1.36670755954144 0.0667887745185687 0.319785883524391 GO:0031491 nucleosome binding 7/921 74/18639 0.0945945945945946 1.9143850691082 0.0725365458132801 0.332081323780889 GO:0043024 ribosomal small subunit binding 3/921 20/18639 0.15 3.035667752443 0.0732966351424712 0.332081323780889 GO:0052745 inositol phosphate phosphatase activity 3/921 20/18639 0.15 3.035667752443 0.0732966351424712 0.332081323780889 GO:0140789 histone phosphatase activity 11/921 136/18639 0.0808823529411765 1.63687967043495 0.0739306733934522 0.332081323780889 GO:0003725 double-stranded RNA binding 7/921 75/18639 0.0933333333333333 1.88885993485342 0.0767728962958558 0.332081323780889 GO:0044389 ubiquitin-like protein ligase binding 22/921 322/18639 0.0683229813664596 1.38270580856617 0.0783614119240293 0.332081323780889 GO:0019905 syntaxin binding 6/921 61/18639 0.0983606557377049 1.99060180488065 0.0798729943184269 0.332081323780889 GO:0001784 phosphotyrosine residue binding 5/921 47/18639 0.106382978723404 2.15295585279645 0.0810421005589505 0.332081323780889 GO:0019887 protein kinase regulator activity 18/921 255/18639 0.0705882352941176 1.42854953056141 0.0821111405680076 0.332081323780889 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/921 21/18639 0.142857142857143 2.89111214518381 0.0824979462448152 0.332081323780889 GO:0061891 calcium ion sensor activity 3/921 21/18639 0.142857142857143 2.89111214518381 0.0824979462448152 0.332081323780889 GO:0000182 rDNA binding 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0005131 growth hormone receptor binding 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0008140 cAMP response element binding protein binding 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0030957 Tat protein binding 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0031720 haptoglobin binding 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0042975 peroxisome proliferator activated receptor binding 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0050815 phosphoserine residue binding 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:1990757 ubiquitin ligase activator activity 2/921 10/18639 0.2 4.04755700325733 0.0843463038299254 0.332081323780889 GO:0140030 modification-dependent protein binding 13/921 173/18639 0.0751445086705202 1.52075841162848 0.0874964809424402 0.332081323780889 GO:0005126 cytokine receptor binding 19/921 275/18639 0.0690909090909091 1.39824696476162 0.0888427294111478 0.332081323780889 GO:0042578 phosphoric ester hydrolase activity 24/921 363/18639 0.0661157024793388 1.33803537297763 0.0907384571993019 0.332081323780889 GO:0004407 histone deacetylase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0008093 cytoskeletal anchor activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0032931 histone H3K56 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0033558 protein lysine deacetylase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0043992 histone H3K9 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0043993 histone H3K18 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0043994 histone H3K23 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0043999 histone H2AK5 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0044012 histone H2AK9 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0044014 histone H2BK5 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0044015 histone H2BK12 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0044016 histone H3K4 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0044017 histone H3K27 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0044018 histone H3K36 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0046972 histone H4K16 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0140517 protein-RNA adaptor activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0140784 metal ion sensor activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0140908 histone H3K122 acetyltransferase activity 3/921 22/18639 0.136363636363636 2.75969795676636 0.0921663693801547 0.332081323780889 GO:0010485 histone H4 acetyltransferase activity 4/921 35/18639 0.114285714285714 2.31288971614704 0.0924577436318414 0.332081323780889 GO:0016410 N-acyltransferase activity 8/921 94/18639 0.0851063829787234 1.72236468223716 0.0931249232982954 0.332081323780889 GO:0042562 hormone binding 8/921 94/18639 0.0851063829787234 1.72236468223716 0.0931249232982954 0.332081323780889 GO:0005004 GPI-linked ephrin receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0005008 hepatocyte growth factor receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0005009 insulin receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0005011 macrophage colony-stimulating factor receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0005018 platelet-derived growth factor alpha-receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0005020 stem cell factor receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0008288 boss receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0036332 placental growth factor receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0038062 protein tyrosine kinase collagen receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0060175 brain-derived neurotrophic factor receptor activity 5/921 49/18639 0.102040816326531 2.06508010370272 0.0931372098718341 0.332081323780889 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 17/921 243/18639 0.0699588477366255 1.41581212048096 0.0947634723710671 0.332081323780889 GO:0061134 peptidase regulator activity 16/921 226/18639 0.0707964601769911 1.43276354097605 0.0949848189176222 0.332081323780889 GO:0005007 fibroblast growth factor receptor activity 5/921 50/18639 0.1 2.02377850162866 0.0995120483498631 0.332081323780889 GO:0005017 platelet-derived growth factor receptor activity 5/921 50/18639 0.1 2.02377850162866 0.0995120483498631 0.332081323780889 GO:0005019 platelet-derived growth factor beta-receptor activity 5/921 50/18639 0.1 2.02377850162866 0.0995120483498631 0.332081323780889 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0019107 myristoyltransferase activity 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0034713 type I transforming growth factor beta receptor binding 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0042608 T cell receptor binding 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0043522 leucine zipper domain binding 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/921 11/18639 0.181818181818182 3.67959727568848 0.0998177262951893 0.332081323780889 GO:0004676 3-phosphoinositide-dependent protein kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0004711 ribosomal protein S6 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0035175 histone H3S10 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0035979 histone H2AXS139 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0044022 histone H3S28 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0044023 histone H4S1 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0044024 histone H2AS1 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0044025 histone H2BS14 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0072354 histone H3T3 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0072371 histone H2AS121 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0072518 Rho-dependent protein serine/threonine kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0140823 histone H2BS36 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0140855 histone H3S57 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0140995 histone H2A kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0140997 histone H4 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0140998 histone H2B kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:1990244 histone H2AT120 kinase activity 17/921 245/18639 0.0693877551020408 1.40425447051785 0.100158575964408 0.332081323780889 GO:0005484 SNAP receptor activity 4/921 36/18639 0.111111111111111 2.24864277958741 0.100161372151626 0.332081323780889 GO:0016409 palmitoyltransferase activity 4/921 36/18639 0.111111111111111 2.24864277958741 0.100161372151626 0.332081323780889 GO:0045505 dynein intermediate chain binding 4/921 36/18639 0.111111111111111 2.24864277958741 0.100161372151626 0.332081323780889 GO:0038024 cargo receptor activity 6/921 65/18639 0.0923076923076923 1.86810323227261 0.101148559848621 0.332081323780889 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 10/921 128/18639 0.078125 1.58107695439739 0.101911207710969 0.332081323780889 GO:0016407 acetyltransferase activity 8/921 96/18639 0.0833333333333333 1.68648208469055 0.102078209602777 0.332081323780889 GO:0004602 glutathione peroxidase activity 3/921 23/18639 0.130434782608696 2.63971108908087 0.102277212329051 0.332081323780889 GO:0042171 lysophosphatidic acid acyltransferase activity 3/921 23/18639 0.130434782608696 2.63971108908087 0.102277212329051 0.332081323780889 GO:0044013 histone H2B acetyltransferase activity 3/921 23/18639 0.130434782608696 2.63971108908087 0.102277212329051 0.332081323780889 GO:0071617 lysophospholipid acyltransferase activity 3/921 23/18639 0.130434782608696 2.63971108908087 0.102277212329051 0.332081323780889 GO:0099186 structural constituent of postsynapse 3/921 23/18639 0.130434782608696 2.63971108908087 0.102277212329051 0.332081323780889 GO:0004677 DNA-dependent protein kinase activity 17/921 246/18639 0.0691056910569106 1.39854611901168 0.102926680217444 0.332114350142622 GO:0140857 histone H3T45 kinase activity 17/921 246/18639 0.0691056910569106 1.39854611901168 0.102926680217444 0.332114350142622 GO:0035402 histone H3T11 kinase activity 17/921 247/18639 0.0688259109311741 1.39288398897519 0.105741833978496 0.339091868838447 GO:0035403 histone H3T6 kinase activity 17/921 247/18639 0.0688259109311741 1.39288398897519 0.105741833978496 0.339091868838447 GO:0004679 AMP-activated protein kinase activity 17/921 248/18639 0.0685483870967742 1.38726752127771 0.108604022793978 0.347198706716748 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/921 24/18639 0.125 2.52972312703583 0.112804917799308 0.354472242332272 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/921 24/18639 0.125 2.52972312703583 0.112804917799308 0.354472242332272 GO:0043998 histone H2A acetyltransferase activity 3/921 24/18639 0.125 2.52972312703583 0.112804917799308 0.354472242332272 GO:0048027 mRNA 5'-UTR binding 3/921 24/18639 0.125 2.52972312703583 0.112804917799308 0.354472242332272 GO:0030159 signaling receptor complex adaptor activity 5/921 52/18639 0.0961538461538462 1.94594086695064 0.112895894423084 0.354472242332272 GO:0035401 histone H3Y41 kinase activity 9/921 115/18639 0.0782608695652174 1.58382665344852 0.115666804890139 0.354472242332272 GO:0140801 histone H2AXY142 kinase activity 9/921 115/18639 0.0782608695652174 1.58382665344852 0.115666804890139 0.354472242332272 GO:0005095 GTPase inhibitor activity 2/921 12/18639 0.166666666666667 3.37296416938111 0.115996691427307 0.354472242332272 GO:0008179 adenylate cyclase binding 2/921 12/18639 0.166666666666667 3.37296416938111 0.115996691427307 0.354472242332272 GO:0035259 nuclear glucocorticoid receptor binding 2/921 12/18639 0.166666666666667 3.37296416938111 0.115996691427307 0.354472242332272 GO:0070008 serine-type exopeptidase activity 2/921 12/18639 0.166666666666667 3.37296416938111 0.115996691427307 0.354472242332272 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/921 12/18639 0.166666666666667 3.37296416938111 0.115996691427307 0.354472242332272 GO:0140900 chloride:bicarbonate antiporter activity 2/921 12/18639 0.166666666666667 3.37296416938111 0.115996691427307 0.354472242332272 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/921 12/18639 0.166666666666667 3.37296416938111 0.115996691427307 0.354472242332272 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/921 12/18639 0.166666666666667 3.37296416938111 0.115996691427307 0.354472242332272 GO:0005003 ephrin receptor activity 5/921 53/18639 0.0943396226415094 1.90922500153648 0.11989552145127 0.361076657356142 GO:0005005 transmembrane-ephrin receptor activity 5/921 53/18639 0.0943396226415094 1.90922500153648 0.11989552145127 0.361076657356142 GO:0005246 calcium channel regulator activity 5/921 53/18639 0.0943396226415094 1.90922500153648 0.11989552145127 0.361076657356142 GO:0017046 peptide hormone binding 5/921 53/18639 0.0943396226415094 1.90922500153648 0.11989552145127 0.361076657356142 GO:0038064 collagen receptor activity 5/921 53/18639 0.0943396226415094 1.90922500153648 0.11989552145127 0.361076657356142 GO:0003707 nuclear steroid receptor activity 3/921 25/18639 0.12 2.4285342019544 0.123723315203579 0.36833388107885 GO:0015645 fatty acid ligase activity 3/921 25/18639 0.12 2.4285342019544 0.123723315203579 0.36833388107885 GO:0019211 phosphatase activator activity 3/921 25/18639 0.12 2.4285342019544 0.123723315203579 0.36833388107885 GO:0120515 fatty acid-CoA ligase activity 3/921 25/18639 0.12 2.4285342019544 0.123723315203579 0.36833388107885 GO:0019208 phosphatase regulator activity 9/921 117/18639 0.0769230769230769 1.55675269356051 0.124927883257768 0.36923337269233 GO:1990782 protein tyrosine kinase binding 9/921 117/18639 0.0769230769230769 1.55675269356051 0.124927883257768 0.36923337269233 GO:0008080 N-acetyltransferase activity 6/921 69/18639 0.0869565217391304 1.75980739272058 0.125091575734071 0.36923337269233 GO:0016247 channel regulator activity 12/921 168/18639 0.0714285714285714 1.4455560725919 0.128376201586008 0.377072775391695 GO:0016791 phosphatase activity 18/921 273/18639 0.0659340659340659 1.3343594516233 0.131167192451897 0.377072775391695 GO:0008238 exopeptidase activity 8/921 102/18639 0.0784313725490196 1.58727725617934 0.131683833602098 0.377072775391695 GO:0030414 peptidase inhibitor activity 12/921 169/18639 0.0710059171597633 1.43700248636355 0.132378187474713 0.377072775391695 GO:0004465 lipoprotein lipase activity 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0005172 vascular endothelial growth factor receptor binding 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0035325 Toll-like receptor binding 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0035673 oligopeptide transmembrane transporter activity 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0070123 transforming growth factor beta receptor activity, type III 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0140666 annealing activity 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0140852 histone ubiquitin ligase activity 2/921 13/18639 0.153846153846154 3.11350538712102 0.132775684651779 0.377072775391695 GO:0030331 nuclear estrogen receptor binding 4/921 40/18639 0.1 2.02377850162866 0.133736753434189 0.377072775391695 GO:0140313 molecular sequestering activity 5/921 55/18639 0.0909090909090909 1.83979863784424 0.134483992163226 0.377072775391695 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3/921 26/18639 0.115384615384615 2.33512904034077 0.135005844509827 0.377072775391695 GO:0005227 calcium-activated cation channel activity 3/921 26/18639 0.115384615384615 2.33512904034077 0.135005844509827 0.377072775391695 GO:0030507 spectrin binding 3/921 26/18639 0.115384615384615 2.33512904034077 0.135005844509827 0.377072775391695 GO:0052742 phosphatidylinositol kinase activity 3/921 26/18639 0.115384615384615 2.33512904034077 0.135005844509827 0.377072775391695 GO:0070006 metalloaminopeptidase activity 3/921 26/18639 0.115384615384615 2.33512904034077 0.135005844509827 0.377072775391695 GO:0141108 transporter regulator activity 12/921 170/18639 0.0705882352941176 1.42854953056141 0.136448122894578 0.380079355730472 GO:0004722 protein serine/threonine phosphatase activity 8/921 103/18639 0.0776699029126214 1.57186679738149 0.137005935954807 0.380612747211348 GO:0008137 NADH dehydrogenase (ubiquinone) activity 4/921 41/18639 0.0975609756097561 1.97441805036943 0.142768332593052 0.395563460171149 GO:0005044 scavenger receptor activity 3/921 27/18639 0.111111111111111 2.24864277958741 0.146625754559088 0.401963480176498 GO:0005104 fibroblast growth factor receptor binding 3/921 27/18639 0.111111111111111 2.24864277958741 0.146625754559088 0.401963480176498 GO:0016405 CoA-ligase activity 3/921 27/18639 0.111111111111111 2.24864277958741 0.146625754559088 0.401963480176498 GO:0035255 ionotropic glutamate receptor binding 3/921 27/18639 0.111111111111111 2.24864277958741 0.146625754559088 0.401963480176498 GO:0005344 oxygen carrier activity 2/921 14/18639 0.142857142857143 2.89111214518381 0.15005606883399 0.409208019733636 GO:0008191 metalloendopeptidase inhibitor activity 2/921 14/18639 0.142857142857143 2.89111214518381 0.15005606883399 0.409208019733636 GO:0043539 protein serine/threonine kinase activator activity 6/921 73/18639 0.0821917808219178 1.66337959037972 0.151521239007984 0.410290198078729 GO:0031492 nucleosomal DNA binding 4/921 42/18639 0.0952380952380952 1.9274080967892 0.152032460308287 0.410290198078729 GO:0042056 chemoattractant activity 4/921 42/18639 0.0952380952380952 1.9274080967892 0.152032460308287 0.410290198078729 GO:0051879 Hsp90 protein binding 4/921 42/18639 0.0952380952380952 1.9274080967892 0.152032460308287 0.410290198078729 GO:0000149 SNARE binding 8/921 106/18639 0.0754716981132075 1.52738000122918 0.153606006017217 0.413462798580022 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/921 58/18639 0.0862068965517241 1.74463663933506 0.15775162845509 0.422552130650185 GO:0004721 phosphoprotein phosphatase activity 12/921 175/18639 0.0685714285714286 1.38773382968823 0.157796175834718 0.422552130650185 GO:0051959 dynein light intermediate chain binding 3/921 28/18639 0.107142857142857 2.16833410888785 0.158556278064599 0.423496074316499 GO:0015459 potassium channel regulator activity 5/921 59/18639 0.0847457627118644 1.71506652680395 0.165851430178629 0.439016681064577 GO:0031593 polyubiquitin modification-dependent protein binding 5/921 59/18639 0.0847457627118644 1.71506652680395 0.165851430178629 0.439016681064577 GO:0004953 icosanoid receptor activity 2/921 15/18639 0.133333333333333 2.69837133550489 0.167747471013125 0.439016681064577 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/921 15/18639 0.133333333333333 2.69837133550489 0.167747471013125 0.439016681064577 GO:0050700 CARD domain binding 2/921 15/18639 0.133333333333333 2.69837133550489 0.167747471013125 0.439016681064577 GO:0050780 dopamine receptor binding 2/921 15/18639 0.133333333333333 2.69837133550489 0.167747471013125 0.439016681064577 GO:0141050 histone H3K deacetylase activity 2/921 15/18639 0.133333333333333 2.69837133550489 0.167747471013125 0.439016681064577 GO:0141051 histone H4K deacetylase activity 2/921 15/18639 0.133333333333333 2.69837133550489 0.167747471013125 0.439016681064577 GO:0099106 ion channel regulator activity 11/921 160/18639 0.06875 1.39134771986971 0.168793566347592 0.440644511143588 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/921 29/18639 0.103448275862069 2.09356396720207 0.170770785338469 0.441409091523842 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/921 29/18639 0.103448275862069 2.09356396720207 0.170770785338469 0.441409091523842 GO:0097472 cyclin-dependent protein kinase activity 3/921 29/18639 0.103448275862069 2.09356396720207 0.170770785338469 0.441409091523842 GO:0003954 NADH dehydrogenase activity 4/921 44/18639 0.0909090909090909 1.83979863784424 0.171210648589132 0.441409091523842 GO:0030547 signaling receptor inhibitor activity 4/921 44/18639 0.0909090909090909 1.83979863784424 0.171210648589132 0.441409091523842 GO:0004866 endopeptidase inhibitor activity 11/921 161/18639 0.0683229813664596 1.38270580856617 0.173669635029351 0.446640472266078 GO:0015026 coreceptor activity 5/921 61/18639 0.0819672131147541 1.65883483740054 0.182526135815374 0.463971464122588 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/921 30/18639 0.1 2.02377850162866 0.183242918635959 0.463971464122588 GO:0022839 monoatomic ion-gated channel activity 3/921 30/18639 0.1 2.02377850162866 0.183242918635959 0.463971464122588 GO:0048019 receptor antagonist activity 3/921 30/18639 0.1 2.02377850162866 0.183242918635959 0.463971464122588 GO:0098918 structural constituent of synapse 3/921 30/18639 0.1 2.02377850162866 0.183242918635959 0.463971464122588 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/921 16/18639 0.125 2.52972312703583 0.185767207964386 0.463971464122588 GO:0004708 MAP kinase kinase activity 2/921 16/18639 0.125 2.52972312703583 0.185767207964386 0.463971464122588 GO:0019841 retinol binding 2/921 16/18639 0.125 2.52972312703583 0.185767207964386 0.463971464122588 GO:0030275 LRR domain binding 2/921 16/18639 0.125 2.52972312703583 0.185767207964386 0.463971464122588 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/921 16/18639 0.125 2.52972312703583 0.185767207964386 0.463971464122588 GO:0070411 I-SMAD binding 2/921 16/18639 0.125 2.52972312703583 0.185767207964386 0.463971464122588 GO:0097027 ubiquitin-protein transferase activator activity 2/921 16/18639 0.125 2.52972312703583 0.185767207964386 0.463971464122588 GO:0030291 protein serine/threonine kinase inhibitor activity 4/921 46/18639 0.0869565217391304 1.75980739272058 0.191173789230278 0.476329896907095 GO:0033293 monocarboxylic acid binding 6/921 79/18639 0.0759493670886076 1.53704696326228 0.195297447824402 0.485440306912807 GO:0016878 acid-thiol ligase activity 3/921 31/18639 0.0967741935483871 1.95849532415677 0.195946708862226 0.485891719589147 GO:0005504 fatty acid binding 4/921 47/18639 0.0851063829787234 1.72236468223716 0.201418597478773 0.495320790742961 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/921 17/18639 0.117647058823529 2.38091588426902 0.204039748256003 0.495320790742961 GO:0015278 intracellularly gated calcium channel activity 2/921 17/18639 0.117647058823529 2.38091588426902 0.204039748256003 0.495320790742961 GO:0016805 dipeptidase activity 2/921 17/18639 0.117647058823529 2.38091588426902 0.204039748256003 0.495320790742961 GO:0030169 low-density lipoprotein particle binding 2/921 17/18639 0.117647058823529 2.38091588426902 0.204039748256003 0.495320790742961 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/921 17/18639 0.117647058823529 2.38091588426902 0.204039748256003 0.495320790742961 GO:0032183 SUMO binding 2/921 17/18639 0.117647058823529 2.38091588426902 0.204039748256003 0.495320790742961 GO:0036041 long-chain fatty acid binding 2/921 17/18639 0.117647058823529 2.38091588426902 0.204039748256003 0.495320790742961 GO:0070492 oligosaccharide binding 2/921 17/18639 0.117647058823529 2.38091588426902 0.204039748256003 0.495320790742961 GO:0015106 bicarbonate transmembrane transporter activity 3/921 32/18639 0.09375 1.89729234527687 0.208856676251452 0.503485119780182 GO:0071813 lipoprotein particle binding 3/921 32/18639 0.09375 1.89729234527687 0.208856676251452 0.503485119780182 GO:0071814 protein-lipid complex binding 3/921 32/18639 0.09375 1.89729234527687 0.208856676251452 0.503485119780182 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/921 48/18639 0.0833333333333333 1.68648208469055 0.21182216589069 0.509451922130618 GO:0000510 H3-H4 histone complex chaperone activity 10/921 151/18639 0.0662251655629139 1.34025066333024 0.213937847279013 0.509819778263519 GO:0140584 chromatin extrusion motor activity 10/921 151/18639 0.0662251655629139 1.34025066333024 0.213937847279013 0.509819778263519 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 10/921 151/18639 0.0662251655629139 1.34025066333024 0.213937847279013 0.509819778263519 GO:0140849 ATP-dependent H2AZ histone chaperone activity 10/921 151/18639 0.0662251655629139 1.34025066333024 0.213937847279013 0.509819778263519 GO:0015616 DNA translocase activity 10/921 152/18639 0.0657894736842105 1.3314332247557 0.219685959880829 0.516012412362716 GO:0140674 ATP-dependent histone chaperone activity 10/921 152/18639 0.0657894736842105 1.3314332247557 0.219685959880829 0.516012412362716 GO:0019956 chemokine binding 3/921 33/18639 0.0909090909090909 1.83979863784424 0.221947916502856 0.516012412362716 GO:0071889 14-3-3 protein binding 3/921 33/18639 0.0909090909090909 1.83979863784424 0.221947916502856 0.516012412362716 GO:0035254 glutamate receptor binding 4/921 49/18639 0.0816326530612245 1.65206408296217 0.222371939759033 0.516012412362716 GO:0000900 mRNA regulatory element binding translation repressor activity 2/921 18/18639 0.111111111111111 2.24864277958741 0.22249620860298 0.516012412362716 GO:0004706 JUN kinase kinase kinase activity 2/921 18/18639 0.111111111111111 2.24864277958741 0.22249620860298 0.516012412362716 GO:0017075 syntaxin-1 binding 2/921 18/18639 0.111111111111111 2.24864277958741 0.22249620860298 0.516012412362716 GO:0017128 phospholipid scramblase activity 2/921 18/18639 0.111111111111111 2.24864277958741 0.22249620860298 0.516012412362716 GO:0034185 apolipoprotein binding 2/921 18/18639 0.111111111111111 2.24864277958741 0.22249620860298 0.516012412362716 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/921 18/18639 0.111111111111111 2.24864277958741 0.22249620860298 0.516012412362716 GO:0070064 proline-rich region binding 2/921 18/18639 0.111111111111111 2.24864277958741 0.22249620860298 0.516012412362716 GO:0061775 cohesin loader activity 10/921 153/18639 0.065359477124183 1.32273104681612 0.225494759834228 0.521801905273415 GO:0008235 metalloexopeptidase activity 5/921 66/18639 0.0757575757575758 1.53316553153687 0.226646506038997 0.523301599498928 GO:0004860 protein kinase inhibitor activity 6/921 84/18639 0.0714285714285714 1.4455560725919 0.234940504483827 0.538257322725818 GO:0008376 acetylgalactosaminyltransferase activity 3/921 34/18639 0.0882352941176471 1.78568691320176 0.235196173741599 0.538257322725818 GO:0051427 hormone receptor binding 3/921 34/18639 0.0882352941176471 1.78568691320176 0.235196173741599 0.538257322725818 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/921 34/18639 0.0882352941176471 1.78568691320176 0.235196173741599 0.538257322725818 GO:0016500 protein-hormone receptor activity 5/921 67/18639 0.0746268656716418 1.51028246390199 0.235827959985479 0.538517033900907 GO:0008094 ATP-dependent activity, acting on DNA 13/921 210/18639 0.0619047619047619 1.25281526291298 0.240200598453432 0.543331374973296 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/921 19/18639 0.105263157894737 2.13029315960912 0.241073882447247 0.543331374973296 GO:0016918 retinal binding 2/921 19/18639 0.105263157894737 2.13029315960912 0.241073882447247 0.543331374973296 GO:0030506 ankyrin binding 2/921 19/18639 0.105263157894737 2.13029315960912 0.241073882447247 0.543331374973296 GO:0042577 lipid phosphatase activity 2/921 19/18639 0.105263157894737 2.13029315960912 0.241073882447247 0.543331374973296 GO:0097001 ceramide binding 2/921 19/18639 0.105263157894737 2.13029315960912 0.241073882447247 0.543331374973296 GO:1990841 promoter-specific chromatin binding 5/921 68/18639 0.0735294117647059 1.48807242766814 0.245110767787033 0.551233956127116 GO:0005085 guanyl-nucleotide exchange factor activity 14/921 230/18639 0.0608695652173913 1.2318651749044 0.248373361964804 0.557364844668318 GO:0140658 ATP-dependent chromatin remodeler activity 10/921 158/18639 0.0632911392405063 1.28087246938523 0.25538527756853 0.571864878003669 GO:0016004 phospholipase activator activity 2/921 20/18639 0.1 2.02377850162866 0.259715798814444 0.578071069719842 GO:0140939 histone H4 methyltransferase activity 2/921 20/18639 0.1 2.02377850162866 0.259715798814444 0.578071069719842 GO:0008081 phosphoric diester hydrolase activity 6/921 87/18639 0.0689655172413793 1.39570931146804 0.25982597647658 0.578071069719842 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/921 36/18639 0.0833333333333333 1.68648208469055 0.262070313329185 0.581818494762871 GO:0140296 general transcription initiation factor binding 4/921 53/18639 0.0754716981132075 1.52738000122918 0.265784304932593 0.588805741631054 GO:0003689 DNA clamp loader activity 10/921 160/18639 0.0625 1.26486156351792 0.267701220760561 0.591790571000474 GO:0019213 deacetylase activity 3/921 37/18639 0.0810810810810811 1.64090148780703 0.275651422755204 0.606345391375442 GO:0051287 NAD binding 4/921 54/18639 0.0740740740740741 1.4990951863916 0.276879576278042 0.606345391375442 GO:0019888 protein phosphatase regulator activity 7/921 107/18639 0.0654205607476635 1.32396724405614 0.277706227611877 0.606345391375442 GO:0010314 phosphatidylinositol-5-phosphate binding 2/921 21/18639 0.0952380952380952 1.9274080967892 0.278370309611247 0.606345391375442 GO:0035613 RNA stem-loop binding 2/921 21/18639 0.0952380952380952 1.9274080967892 0.278370309611247 0.606345391375442 GO:0051428 peptide hormone receptor binding 2/921 21/18639 0.0952380952380952 1.9274080967892 0.278370309611247 0.606345391375442 GO:0072542 protein phosphatase activator activity 2/921 21/18639 0.0952380952380952 1.9274080967892 0.278370309611247 0.606345391375442 GO:0046982 protein heterodimerization activity 21/921 369/18639 0.0569105691056911 1.1517438627155 0.282883806114761 0.61488760366786 GO:0019210 kinase inhibitor activity 6/921 90/18639 0.0666666666666667 1.34918566775244 0.28536317016281 0.618981907722672 GO:0008374 O-acyltransferase activity 4/921 55/18639 0.0727272727272727 1.47183891027539 0.288047857385087 0.623503591298136 GO:0005501 retinoid binding 3/921 38/18639 0.0789473684210526 1.59771986970684 0.289300075812969 0.623615723588537 GO:0019840 isoprenoid binding 3/921 38/18639 0.0789473684210526 1.59771986970684 0.289300075812969 0.623615723588537 GO:0140713 histone chaperone activity 10/921 164/18639 0.0609756097560976 1.23401128148089 0.292863304002206 0.629989591839114 GO:0050321 tau-protein kinase activity 2/921 22/18639 0.0909090909090909 1.83979863784424 0.296990703634356 0.637548225363835 GO:0061135 endopeptidase regulator activity 11/921 184/18639 0.0597826086956522 1.2098675824954 0.301564587124044 0.646032177364704 GO:0035064 methylated histone binding 5/921 74/18639 0.0675675675675676 1.36741790650585 0.302508596933416 0.646432890803667 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/921 39/18639 0.0769230769230769 1.55675269356051 0.302995974804029 0.646432890803667 GO:1901981 phosphatidylinositol phosphate binding 11/921 185/18639 0.0594594594594595 1.20332775772515 0.307658211987213 0.655034594784251 GO:0016504 peptidase activator activity 4/921 57/18639 0.0701754385964912 1.42019543973941 0.310557450561555 0.659855196591933 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 10/921 167/18639 0.0598802395209581 1.2118434141489 0.312134858472309 0.661853301944345 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/921 23/18639 0.0869565217391304 1.75980739272058 0.315534845663433 0.667700009458874 GO:0004177 aminopeptidase activity 3/921 40/18639 0.075 1.5178338762215 0.316719695455638 0.668845047923593 GO:0004857 enzyme inhibitor activity 23/921 416/18639 0.0552884615384615 1.11891599849662 0.318805427557947 0.671884055238757 GO:0061980 regulatory RNA binding 4/921 58/18639 0.0689655172413793 1.39570931146804 0.321876400347219 0.676102934038478 GO:0140034 methylation-dependent protein binding 5/921 76/18639 0.0657894736842105 1.3314332247557 0.322108712559236 0.676102934038478 GO:0016887 ATP hydrolysis activity 23/921 417/18639 0.0551558752997602 1.11623274670166 0.322926415827052 0.676452713799005 GO:0008276 protein methyltransferase activity 6/921 95/18639 0.0631578947368421 1.27817589576547 0.328986416515744 0.68305013352509 GO:0001530 lipopolysaccharide binding 3/921 41/18639 0.0731707317073171 1.48081353777707 0.330452697786895 0.68305013352509 GO:0001727 lipid kinase activity 3/921 41/18639 0.0731707317073171 1.48081353777707 0.330452697786895 0.68305013352509 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/921 41/18639 0.0731707317073171 1.48081353777707 0.330452697786895 0.68305013352509 GO:0070888 E-box binding 4/921 59/18639 0.0677966101694915 1.37205322144316 0.333223670904935 0.68305013352509 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/921 24/18639 0.0833333333333333 1.68648208469055 0.333964839105626 0.68305013352509 GO:0004806 triacylglycerol lipase activity 2/921 24/18639 0.0833333333333333 1.68648208469055 0.333964839105626 0.68305013352509 GO:0005315 phosphate transmembrane transporter activity 2/921 24/18639 0.0833333333333333 1.68648208469055 0.333964839105626 0.68305013352509 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/921 24/18639 0.0833333333333333 1.68648208469055 0.333964839105626 0.68305013352509 GO:0030215 semaphorin receptor binding 2/921 24/18639 0.0833333333333333 1.68648208469055 0.333964839105626 0.68305013352509 GO:0050699 WW domain binding 2/921 24/18639 0.0833333333333333 1.68648208469055 0.333964839105626 0.68305013352509 GO:0060229 lipase activator activity 2/921 24/18639 0.0833333333333333 1.68648208469055 0.333964839105626 0.68305013352509 GO:0035198 miRNA binding 3/921 42/18639 0.0714285714285714 1.4455560725919 0.344177331439095 0.702554513487662 GO:0004709 MAP kinase kinase kinase activity 2/921 25/18639 0.08 1.61902280130293 0.352246710749283 0.714813149352549 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/921 25/18639 0.08 1.61902280130293 0.352246710749283 0.714813149352549 GO:0017025 TBP-class protein binding 2/921 25/18639 0.08 1.61902280130293 0.352246710749283 0.714813149352549 GO:0008170 N-methyltransferase activity 6/921 98/18639 0.0612244897959184 1.23904806222163 0.355568870731058 0.720148258654132 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 26/921 484/18639 0.0537190082644628 1.08715374054432 0.358162236642073 0.723989423873762 GO:0022853 active monoatomic ion transmembrane transporter activity 7/921 118/18639 0.0593220338983051 1.20054656876277 0.365675773126491 0.737741996657134 GO:0004435 phosphatidylinositol phospholipase C activity 2/921 26/18639 0.0769230769230769 1.55675269356051 0.370350116269237 0.739609250475233 GO:0008143 poly(A) binding 2/921 26/18639 0.0769230769230769 1.55675269356051 0.370350116269237 0.739609250475233 GO:0070412 R-SMAD binding 2/921 26/18639 0.0769230769230769 1.55675269356051 0.370350116269237 0.739609250475233 GO:0001046 core promoter sequence-specific DNA binding 3/921 44/18639 0.0681818181818182 1.37984897838318 0.371535337629529 0.739609250475233 GO:0043014 alpha-tubulin binding 3/921 44/18639 0.0681818181818182 1.37984897838318 0.371535337629529 0.739609250475233 GO:0015101 organic cation transmembrane transporter activity 5/921 81/18639 0.0617283950617284 1.24924598865967 0.371584243260897 0.739609250475233 GO:0030971 receptor tyrosine kinase binding 5/921 81/18639 0.0617283950617284 1.24924598865967 0.371584243260897 0.739609250475233 GO:0043021 ribonucleoprotein complex binding 10/921 177/18639 0.0564971751412429 1.14337768453597 0.378087838656819 0.743639396549966 GO:0032182 ubiquitin-like protein binding 7/921 120/18639 0.0583333333333333 1.18053745928339 0.381985669652654 0.743639396549966 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/921 45/18639 0.0666666666666667 1.34918566775244 0.385137840330589 0.743639396549966 GO:0046915 transition metal ion transmembrane transporter activity 3/921 45/18639 0.0666666666666667 1.34918566775244 0.385137840330589 0.743639396549966 GO:0001216 DNA-binding transcription activator activity 26/921 491/18639 0.0529531568228106 1.07165460371375 0.386206242119071 0.743639396549966 GO:0004364 glutathione transferase activity 2/921 27/18639 0.0740740740740741 1.4990951863916 0.388248065206049 0.743639396549966 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/921 27/18639 0.0740740740740741 1.4990951863916 0.388248065206049 0.743639396549966 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/921 27/18639 0.0740740740740741 1.4990951863916 0.388248065206049 0.743639396549966 GO:0001094 TFIID-class transcription factor complex binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0003796 lysozyme activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0004955 prostaglandin receptor activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0005381 iron ion transmembrane transporter activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0005522 profilin binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0016783 sulfurtransferase activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0019531 oxalate transmembrane transporter activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0035374 chondroitin sulfate binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0043208 glycosphingolipid binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0043295 glutathione binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0043422 protein kinase B binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0047429 nucleoside triphosphate diphosphatase activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0099122 RNA polymerase II C-terminal domain binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0140135 mechanosensitive monoatomic cation channel activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0140940 histone H2A methyltransferase activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0141109 transporter activator activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:1905394 retromer complex binding 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:1990259 histone H2AQ104 methyltransferase activity 1/921 10/18639 0.1 2.02377850162866 0.39762579198797 0.743639396549966 GO:0004180 carboxypeptidase activity 3/921 46/18639 0.0652173913043478 1.31985554454043 0.398670215988751 0.743639396549966 GO:0005242 inward rectifier potassium channel activity 2/921 28/18639 0.0714285714285714 1.4455560725919 0.40591666421693 0.743639396549966 GO:0019789 SUMO transferase activity 2/921 28/18639 0.0714285714285714 1.4455560725919 0.40591666421693 0.743639396549966 GO:0046625 sphingolipid binding 2/921 28/18639 0.0714285714285714 1.4455560725919 0.40591666421693 0.743639396549966 GO:0046875 ephrin receptor binding 2/921 28/18639 0.0714285714285714 1.4455560725919 0.40591666421693 0.743639396549966 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/921 28/18639 0.0714285714285714 1.4455560725919 0.40591666421693 0.743639396549966 GO:0022804 active transmembrane transporter activity 24/921 457/18639 0.0525164113785558 1.06281584330608 0.408806074242571 0.743639396549966 GO:0140359 ABC-type transporter activity 3/921 47/18639 0.0638297872340425 1.29177351167787 0.412119189978067 0.743639396549966 GO:0140938 histone H3 methyltransferase activity 3/921 47/18639 0.0638297872340425 1.29177351167787 0.412119189978067 0.743639396549966 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/921 86/18639 0.0581395348837209 1.17661540792364 0.421074029479178 0.743639396549966 GO:0004629 phospholipase C activity 2/921 29/18639 0.0689655172413793 1.39570931146804 0.423334877467187 0.743639396549966 GO:0051861 glycolipid binding 2/921 29/18639 0.0689655172413793 1.39570931146804 0.423334877467187 0.743639396549966 GO:0099604 ligand-gated calcium channel activity 2/921 29/18639 0.0689655172413793 1.39570931146804 0.423334877467187 0.743639396549966 GO:0106222 lncRNA binding 2/921 29/18639 0.0689655172413793 1.39570931146804 0.423334877467187 0.743639396549966 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/921 67/18639 0.0597014925373134 1.20822597112159 0.423832656267336 0.743639396549966 GO:0008237 metallopeptidase activity 10/921 184/18639 0.0543478260869565 1.09987962045036 0.425008985422384 0.743639396549966 GO:0140693 molecular condensate scaffold activity 3/921 48/18639 0.0625 1.26486156351792 0.425472324917226 0.743639396549966 GO:0008168 methyltransferase activity 11/921 204/18639 0.053921568627451 1.0912531136233 0.427238613705701 0.743639396549966 GO:0004016 adenylate cyclase activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0004954 prostanoid receptor activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0005225 volume-sensitive anion channel activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0008046 axon guidance receptor activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0008172 S-methyltransferase activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0008271 secondary active sulfate transmembrane transporter activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0008432 JUN kinase binding 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0008526 phosphatidylinositol transfer activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0010854 adenylate cyclase regulator activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0015217 ADP transmembrane transporter activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0019206 nucleoside kinase activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0034056 estrogen response element binding 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0140537 transcription regulator activator activity 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:1900750 oligopeptide binding 1/921 11/18639 0.0909090909090909 1.83979863784424 0.427406598557247 0.743639396549966 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/921 68/18639 0.0588235294117647 1.19045794213451 0.435002774297355 0.743639396549966 GO:0015399 primary active transmembrane transporter activity 9/921 166/18639 0.0542168674698795 1.09722930811193 0.43648361557068 0.743639396549966 GO:0001222 transcription corepressor binding 3/921 49/18639 0.0612244897959184 1.23904806222163 0.438718002210151 0.743639396549966 GO:0051721 protein phosphatase 2A binding 2/921 30/18639 0.0666666666666667 1.34918566775244 0.440484303097989 0.743639396549966 GO:0004197 cysteine-type endopeptidase activity 5/921 88/18639 0.0568181818181818 1.14987414865265 0.440703409161548 0.743639396549966 GO:0031406 carboxylic acid binding 10/921 187/18639 0.053475935828877 1.08223449284955 0.445109236613191 0.743639396549966 GO:0031490 chromatin DNA binding 7/921 128/18639 0.0546875 1.10675386807818 0.447169003836398 0.743639396549966 GO:0015291 secondary active transmembrane transporter activity 15/921 287/18639 0.0522648083623693 1.05772395555505 0.449361678742449 0.743639396549966 GO:0140597 protein carrier chaperone 10/921 188/18639 0.0531914893617021 1.07647792639823 0.451794286075464 0.743639396549966 GO:0015605 organophosphate ester transmembrane transporter activity 3/921 50/18639 0.06 1.2142671009772 0.451845401803742 0.743639396549966 GO:0000340 RNA 7-methylguanosine cap binding 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0004000 adenosine deaminase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0004300 enoyl-CoA hydratase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0005025 transforming growth factor beta receptor activity, type I 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0005026 transforming growth factor beta receptor activity, type II 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0005165 neurotrophin receptor binding 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0005247 voltage-gated chloride channel activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0008504 monoamine transmembrane transporter activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0015132 prostaglandin transmembrane transporter activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0015166 polyol transmembrane transporter activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0015269 calcium-activated potassium channel activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0015368 calcium:monoatomic cation antiporter activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0016273 arginine N-methyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0016274 protein-arginine N-methyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0016361 activin receptor activity, type I 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0016362 activin receptor activity, type II 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0017002 activin receptor activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0034452 dynactin binding 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0035251 UDP-glucosyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0035497 cAMP response element binding 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0036009 protein-glutamine N-methyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0045295 gamma-catenin binding 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0070679 inositol 1,4,5 trisphosphate binding 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/921 12/18639 0.0833333333333333 1.68648208469055 0.455716590114514 0.743639396549966 GO:0017147 Wnt-protein binding 2/921 31/18639 0.0645161290322581 1.30566354943785 0.457348964769421 0.743639396549966 GO:0047499 calcium-independent phospholipase A2 activity 2/921 31/18639 0.0645161290322581 1.30566354943785 0.457348964769421 0.743639396549966 GO:0072349 modified amino acid transmembrane transporter activity 2/921 31/18639 0.0645161290322581 1.30566354943785 0.457348964769421 0.743639396549966 GO:0043177 organic acid binding 10/921 189/18639 0.0529100529100529 1.070782275994 0.45846879200763 0.744295429524887 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7/921 130/18639 0.0538461538461538 1.08972688549236 0.463316678156917 0.750992244313631 GO:0030544 Hsp70 protein binding 3/921 51/18639 0.0588235294117647 1.19045794213451 0.464844480460158 0.752295039249384 GO:0140299 molecular sensor activity 4/921 71/18639 0.0563380281690141 1.14015690232601 0.468116340176033 0.754330051120033 GO:1902936 phosphatidylinositol bisphosphate binding 6/921 111/18639 0.0540540540540541 1.09393432520468 0.47080137191875 0.754330051120033 GO:0031072 heat shock protein binding 7/921 131/18639 0.0534351145038168 1.0814083596489 0.471351079887477 0.754330051120033 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/921 32/18639 0.0625 1.26486156351792 0.473915117337285 0.754330051120033 GO:0047498 calcium-dependent phospholipase A2 activity 2/921 32/18639 0.0625 1.26486156351792 0.473915117337285 0.754330051120033 GO:0070717 poly-purine tract binding 2/921 32/18639 0.0625 1.26486156351792 0.473915117337285 0.754330051120033 GO:0043178 alcohol binding 5/921 92/18639 0.0543478260869565 1.09987962045036 0.479439874977894 0.754330051120033 GO:0043022 ribosome binding 6/921 112/18639 0.0535714285714286 1.08416705444393 0.479497203790461 0.754330051120033 GO:0002161 aminoacyl-tRNA editing activity 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0008253 5'-nucleotidase activity 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0031432 titin binding 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0045159 myosin II binding 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0046975 histone H3K36 methyltransferase activity 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0061459 L-arginine transmembrane transporter activity 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0070700 BMP receptor binding 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0071714 icosanoid transmembrane transporter activity 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0071837 HMG box domain binding 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0089720 caspase binding 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0097157 pre-mRNA intronic binding 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/921 13/18639 0.0769230769230769 1.55675269356051 0.48262833223641 0.754330051120033 GO:0051213 dioxygenase activity 5/921 93/18639 0.0537634408602151 1.08805295786487 0.488987063470937 0.754330051120033 GO:0140416 transcription regulator inhibitor activity 2/921 33/18639 0.0606060606060606 1.22653242522949 0.490171065778216 0.754330051120033 GO:0005544 calcium-dependent phospholipid binding 3/921 53/18639 0.0566037735849057 1.14553500092189 0.490421247445143 0.754330051120033 GO:1901505 carbohydrate derivative transmembrane transporter activity 3/921 53/18639 0.0566037735849057 1.14553500092189 0.490421247445143 0.754330051120033 GO:0008236 serine-type peptidase activity 10/921 194/18639 0.0515463917525773 1.04318479465395 0.49162209519731 0.754330051120033 GO:0003823 antigen binding 9/921 174/18639 0.0517241379310345 1.04678198360103 0.492727228256419 0.754330051120033 GO:0051087 protein-folding chaperone binding 7/921 134/18639 0.0522388059701493 1.05719772473139 0.495262143853616 0.754330051120033 GO:0016741 transferase activity, transferring one-carbon groups 11/921 215/18639 0.0511627906976744 1.03542155897281 0.496861431980197 0.754330051120033 GO:0003925 G protein activity 3/921 54/18639 0.0555555555555556 1.1243213897937 0.502982522219678 0.754330051120033 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/921 54/18639 0.0555555555555556 1.1243213897937 0.502982522219678 0.754330051120033 GO:0050661 NADP binding 3/921 54/18639 0.0555555555555556 1.1243213897937 0.502982522219678 0.754330051120033 GO:0140463 chromatin-protein adaptor activity 3/921 54/18639 0.0555555555555556 1.1243213897937 0.502982522219678 0.754330051120033 GO:0015297 antiporter activity 7/921 135/18639 0.0518518518518519 1.04936663047412 0.503159360147943 0.754330051120033 GO:0016831 carboxy-lyase activity 2/921 34/18639 0.0588235294117647 1.19045794213451 0.506106996530504 0.754330051120033 GO:0019825 oxygen binding 2/921 34/18639 0.0588235294117647 1.19045794213451 0.506106996530504 0.754330051120033 GO:0090482 vitamin transmembrane transporter activity 2/921 34/18639 0.0588235294117647 1.19045794213451 0.506106996530504 0.754330051120033 GO:0004252 serine-type endopeptidase activity 9/921 176/18639 0.0511363636363636 1.03488673378739 0.50657784825296 0.754330051120033 GO:0004867 serine-type endopeptidase inhibitor activity 5/921 95/18639 0.0526315789473684 1.06514657980456 0.507886391992306 0.754330051120033 GO:0004705 JUN kinase activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0005347 ATP transmembrane transporter activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0005545 1-phosphatidylinositol binding 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0008195 phosphatidate phosphatase activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0008474 palmitoyl-(protein) hydrolase activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0008494 translation activator activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0008559 ABC-type xenobiotic transporter activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0034236 protein kinase A catalytic subunit binding 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0042813 Wnt receptor activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0046030 inositol trisphosphate phosphatase activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0061665 SUMO ligase activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0061783 peptidoglycan muralytic activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0098599 palmitoyl hydrolase activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0098821 BMP receptor activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:1901474 azole transmembrane transporter activity 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:1901612 cardiolipin binding 1/921 14/18639 0.0714285714285714 1.4455560725919 0.508210814036596 0.754330051120033 GO:0099094 ligand-gated monoatomic cation channel activity 7/921 136/18639 0.0514705882352941 1.04165069936769 0.511015664702803 0.757411234844811 GO:0017171 serine hydrolase activity 10/921 198/18639 0.0505050505050505 1.02211035435791 0.517782056656649 0.766346947102932 GO:0004623 phospholipase A2 activity 2/921 35/18639 0.0571428571428571 1.15644485807352 0.521714820467845 0.768881841795874 GO:0016229 steroid dehydrogenase activity 2/921 35/18639 0.0571428571428571 1.15644485807352 0.521714820467845 0.768881841795874 GO:0140566 histone reader activity 2/921 35/18639 0.0571428571428571 1.15644485807352 0.521714820467845 0.768881841795874 GO:0003724 RNA helicase activity 4/921 77/18639 0.051948051948052 1.05131350733957 0.531990954326535 0.770610417267977 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0008252 nucleotidase activity 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0010181 FMN binding 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0015116 sulfate transmembrane transporter activity 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0016846 carbon-sulfur lyase activity 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0017081 chloride channel regulator activity 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0030553 cGMP binding 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0033130 acetylcholine receptor binding 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0042809 nuclear vitamin D receptor binding 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0045504 dynein heavy chain binding 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0048531 beta-1,3-galactosyltransferase activity 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0120283 protein serine/threonine kinase binding 1/921 15/18639 0.0666666666666667 1.34918566775244 0.532529624252558 0.770610417267977 GO:0042626 ATPase-coupled transmembrane transporter activity 5/921 98/18639 0.0510204081632653 1.03254005185136 0.535689051552266 0.771688187848069 GO:0055106 ubiquitin-protein transferase regulator activity 2/921 36/18639 0.0555555555555556 1.1243213897937 0.536988026770119 0.771688187848069 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/921 36/18639 0.0555555555555556 1.1243213897937 0.536988026770119 0.771688187848069 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/921 36/18639 0.0555555555555556 1.1243213897937 0.536988026770119 0.771688187848069 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/921 36/18639 0.0555555555555556 1.1243213897937 0.536988026770119 0.771688187848069 GO:0022829 wide pore channel activity 2/921 37/18639 0.0540540540540541 1.09393432520468 0.551921546999543 0.788684912978099 GO:0008186 ATP-dependent activity, acting on RNA 4/921 79/18639 0.0506329113924051 1.02469797550818 0.552430277288346 0.788684912978099 GO:0043130 ubiquitin binding 5/921 100/18639 0.05 1.01188925081433 0.553818662630567 0.788684912978099 GO:0004707 MAP kinase activity 1/921 16/18639 0.0625 1.26486156351792 0.555647118671769 0.788684912978099 GO:0015378 sodium:chloride symporter activity 1/921 16/18639 0.0625 1.26486156351792 0.555647118671769 0.788684912978099 GO:0015562 efflux transmembrane transporter activity 1/921 16/18639 0.0625 1.26486156351792 0.555647118671769 0.788684912978099 GO:0022858 alanine transmembrane transporter activity 1/921 16/18639 0.0625 1.26486156351792 0.555647118671769 0.788684912978099 GO:0034450 ubiquitin-ubiquitin ligase activity 1/921 16/18639 0.0625 1.26486156351792 0.555647118671769 0.788684912978099 GO:0043023 ribosomal large subunit binding 1/921 16/18639 0.0625 1.26486156351792 0.555647118671769 0.788684912978099 GO:0020037 heme binding 7/921 142/18639 0.0492957746478873 0.997637289535257 0.557161196413842 0.789755092870371 GO:0036002 pre-mRNA binding 3/921 59/18639 0.0508474576271186 1.02903991608237 0.563249805977199 0.796212991034435 GO:0070063 RNA polymerase binding 3/921 59/18639 0.0508474576271186 1.02903991608237 0.563249805977199 0.796212991034435 GO:0005109 frizzled binding 2/921 38/18639 0.0526315789473684 1.06514657980456 0.56651162873213 0.798650722188173 GO:0042887 amide transmembrane transporter activity 2/921 38/18639 0.0526315789473684 1.06514657980456 0.56651162873213 0.798650722188173 GO:0015103 inorganic anion transmembrane transporter activity 8/921 165/18639 0.0484848484848485 0.981225940183595 0.572892457788868 0.800199813221789 GO:0008514 organic anion transmembrane transporter activity 13/921 269/18639 0.0483271375464684 0.978034220117942 0.573124012126072 0.800199813221789 GO:0140104 molecular carrier activity 12/921 249/18639 0.0481927710843374 0.975314940543935 0.577312879499418 0.800199813221789 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0005092 GDP-dissociation inhibitor activity 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0016018 cyclosporin A binding 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0019198 transmembrane receptor protein phosphatase activity 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0030548 acetylcholine receptor regulator activity 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0031489 myosin V binding 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0070403 NAD+ binding 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:1990226 histone methyltransferase binding 1/921 17/18639 0.0588235294117647 1.19045794213451 0.577622579322754 0.800199813221789 GO:0008194 UDP-glycosyltransferase activity 7/921 145/18639 0.0482758620689655 0.976996518027631 0.579499428557638 0.801334915193707 GO:0000217 DNA secondary structure binding 2/921 39/18639 0.0512820512820513 1.03783512904034 0.580755718133649 0.801334915193707 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/921 39/18639 0.0512820512820513 1.03783512904034 0.580755718133649 0.801334915193707 GO:0016836 hydro-lyase activity 3/921 61/18639 0.0491803278688525 0.995300902440327 0.586075349306112 0.805787201801985 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/921 40/18639 0.05 1.01188925081433 0.594652350906176 0.805787201801985 GO:0032451 demethylase activity 2/921 40/18639 0.05 1.01188925081433 0.594652350906176 0.805787201801985 GO:0050997 quaternary ammonium group binding 2/921 40/18639 0.05 1.01188925081433 0.594652350906176 0.805787201801985 GO:0071949 FAD binding 2/921 40/18639 0.05 1.01188925081433 0.594652350906176 0.805787201801985 GO:0015179 L-amino acid transmembrane transporter activity 3/921 62/18639 0.0483870967741935 0.979247662078386 0.597197877849343 0.805787201801985 GO:0000400 four-way junction DNA binding 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0003746 translation elongation factor activity 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0008308 voltage-gated monoatomic anion channel activity 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0008525 phosphatidylcholine transporter activity 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0015373 monoatomic anion:sodium symporter activity 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0016854 racemase and epimerase activity 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0050811 GABA receptor binding 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0099602 neurotransmitter receptor regulator activity 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:1901611 phosphatidylglycerol binding 1/921 18/18639 0.0555555555555556 1.1243213897937 0.598512365835682 0.805787201801985 GO:0005525 GTP binding 18/921 378/18639 0.0476190476190476 0.963704048394602 0.59871772838415 0.805787201801985 GO:0019001 guanyl nucleotide binding 19/921 400/18639 0.0475 0.961294788273616 0.604050552293757 0.810863725882705 GO:0032561 guanyl ribonucleotide binding 19/921 400/18639 0.0475 0.961294788273616 0.604050552293757 0.810863725882705 GO:0005507 copper ion binding 3/921 63/18639 0.0476190476190476 0.963704048394602 0.608123206082987 0.812237650459792 GO:1901682 sulfur compound transmembrane transporter activity 3/921 63/18639 0.0476190476190476 0.963704048394602 0.608123206082987 0.812237650459792 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/921 41/18639 0.0487804878048781 0.987209025184714 0.608201051066139 0.812237650459792 GO:0140828 metal cation:monoatomic cation antiporter activity 2/921 41/18639 0.0487804878048781 0.987209025184714 0.608201051066139 0.812237650459792 GO:0005229 intracellularly calcium-gated chloride channel activity 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0008381 mechanosensitive monoatomic ion channel activity 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0008574 plus-end-directed microtubule motor activity 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0034987 immunoglobulin receptor binding 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0042834 peptidoglycan binding 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0046527 glucosyltransferase activity 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0046624 sphingolipid transporter activity 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0140036 ubiquitin-modified protein reader activity 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0141147 intracellularly calcium-gated channel activity 1/921 19/18639 0.0526315789473684 1.06514657980456 0.618370059357262 0.815338187401263 GO:0050660 flavin adenine dinucleotide binding 4/921 86/18639 0.0465116279069767 0.941292326338914 0.620001811440318 0.816228728561749 GO:0016859 cis-trans isomerase activity 2/921 42/18639 0.0476190476190476 0.963704048394602 0.621402237047491 0.816228728561749 GO:0043175 RNA polymerase core enzyme binding 2/921 42/18639 0.0476190476190476 0.963704048394602 0.621402237047491 0.816228728561749 GO:0160215 deacylase activity 3/921 65/18639 0.0461538461538462 0.934051616136307 0.629373853604456 0.824626513087209 GO:0046906 tetrapyrrole binding 7/921 152/18639 0.0460526315789474 0.93200325732899 0.629382892086772 0.824626513087209 GO:0004620 phospholipase activity 5/921 109/18639 0.0458715596330275 0.928338762214984 0.630737591977137 0.825360652473861 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/921 43/18639 0.0465116279069767 0.941292326338914 0.634257134654489 0.825560120650722 GO:0008375 acetylglucosaminyltransferase activity 2/921 43/18639 0.0465116279069767 0.941292326338914 0.634257134654489 0.825560120650722 GO:0000339 RNA cap binding 1/921 20/18639 0.05 1.01188925081433 0.637246599385831 0.825560120650722 GO:0001972 retinoic acid binding 1/921 20/18639 0.05 1.01188925081433 0.637246599385831 0.825560120650722 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/921 20/18639 0.05 1.01188925081433 0.637246599385831 0.825560120650722 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/921 20/18639 0.05 1.01188925081433 0.637246599385831 0.825560120650722 GO:0005326 neurotransmitter transmembrane transporter activity 1/921 20/18639 0.05 1.01188925081433 0.637246599385831 0.825560120650722 GO:0010851 cyclase regulator activity 1/921 20/18639 0.05 1.01188925081433 0.637246599385831 0.825560120650722 GO:0004222 metalloendopeptidase activity 5/921 110/18639 0.0454545454545455 0.91989931892212 0.638769580044749 0.826502607305721 GO:0005506 iron ion binding 7/921 154/18639 0.0454545454545455 0.91989931892212 0.643008191155047 0.830952127624495 GO:0003727 single-stranded RNA binding 4/921 89/18639 0.0449438202247191 0.909563371518501 0.646916307301883 0.831710102726964 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/921 89/18639 0.0449438202247191 0.909563371518501 0.646916307301883 0.831710102726964 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/921 89/18639 0.0449438202247191 0.909563371518501 0.646916307301883 0.831710102726964 GO:0003730 mRNA 3'-UTR binding 12/921 262/18639 0.0458015267175573 0.926921451127633 0.647814856760714 0.831710102726964 GO:0004386 helicase activity 7/921 155/18639 0.0451612903225806 0.913964484606494 0.649710462878671 0.831710102726964 GO:0042054 histone methyltransferase activity 3/921 67/18639 0.0447761194029851 0.906169478341193 0.649814608395344 0.831710102726964 GO:0016755 aminoacyltransferase activity 23/921 496/18639 0.0463709677419355 0.938445676158453 0.654232307963002 0.831710102726964 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/921 21/18639 0.0476190476190476 0.963704048394602 0.655190413874561 0.831710102726964 GO:0005123 death receptor binding 1/921 21/18639 0.0476190476190476 0.963704048394602 0.655190413874561 0.831710102726964 GO:0005248 voltage-gated sodium channel activity 1/921 21/18639 0.0476190476190476 0.963704048394602 0.655190413874561 0.831710102726964 GO:0009975 cyclase activity 1/921 21/18639 0.0476190476190476 0.963704048394602 0.655190413874561 0.831710102726964 GO:0015174 basic amino acid transmembrane transporter activity 1/921 21/18639 0.0476190476190476 0.963704048394602 0.655190413874561 0.831710102726964 GO:0019200 carbohydrate kinase activity 1/921 21/18639 0.0476190476190476 0.963704048394602 0.655190413874561 0.831710102726964 GO:0036122 BMP binding 1/921 21/18639 0.0476190476190476 0.963704048394602 0.655190413874561 0.831710102726964 GO:0140793 histone H2AXY142 phosphatase activity 4/921 90/18639 0.0444444444444444 0.899457111834962 0.655602092524912 0.831710102726964 GO:0140303 intramembrane lipid transporter activity 2/921 45/18639 0.0444444444444444 0.899457111834962 0.658936526933256 0.833821103930041 GO:0005548 phospholipid transporter activity 3/921 68/18639 0.0441176470588235 0.892843456600881 0.659729000738328 0.833821103930041 GO:0030145 manganese ion binding 3/921 68/18639 0.0441176470588235 0.892843456600881 0.659729000738328 0.833821103930041 GO:0016829 lyase activity 9/921 200/18639 0.045 0.910700325732899 0.660476196857001 0.833821103930041 GO:0002039 p53 binding 3/921 69/18639 0.0434782608695652 0.879903696360289 0.669438890731432 0.83548468553592 GO:0016279 protein-lysine N-methyltransferase activity 3/921 69/18639 0.0434782608695652 0.879903696360289 0.669438890731432 0.83548468553592 GO:0019787 ubiquitin-like protein transferase activity 22/921 479/18639 0.0459290187891441 0.929501608263687 0.669596838053461 0.83548468553592 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/921 46/18639 0.0434782608695652 0.879903696360289 0.67076681379437 0.83548468553592 GO:0005243 gap junction channel activity 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0008970 phospholipase A1 activity 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0015377 chloride:monoatomic cation symporter activity 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0031683 G-protein beta/gamma-subunit complex binding 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0034062 5'-3' RNA polymerase activity 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0070034 telomerase RNA binding 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0097747 RNA polymerase activity 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0140035 ubiquitin-like protein reader activity 1/921 22/18639 0.0454545454545455 0.91989931892212 0.672247542933618 0.83548468553592 GO:0016278 lysine N-methyltransferase activity 3/921 70/18639 0.0428571428571429 0.867333643555142 0.678944295446886 0.841793702827344 GO:0016782 transferase activity, transferring sulphur-containing groups 3/921 70/18639 0.0428571428571429 0.867333643555142 0.678944295446886 0.841793702827344 GO:0061749 forked DNA-dependent helicase activity 2/921 47/18639 0.0425531914893617 0.861182341118581 0.682262263741761 0.842890002411046 GO:0099095 ligand-gated monoatomic anion channel activity 2/921 47/18639 0.0425531914893617 0.861182341118581 0.682262263741761 0.842890002411046 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/921 47/18639 0.0425531914893617 0.861182341118581 0.682262263741761 0.842890002411046 GO:0000295 adenine nucleotide transmembrane transporter activity 1/921 23/18639 0.0434782608695652 0.879903696360289 0.688461756445899 0.843528024701992 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/921 23/18639 0.0434782608695652 0.879903696360289 0.688461756445899 0.843528024701992 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/921 23/18639 0.0434782608695652 0.879903696360289 0.688461756445899 0.843528024701992 GO:0005283 amino acid:sodium symporter activity 1/921 23/18639 0.0434782608695652 0.879903696360289 0.688461756445899 0.843528024701992 GO:0016849 phosphorus-oxygen lyase activity 1/921 23/18639 0.0434782608695652 0.879903696360289 0.688461756445899 0.843528024701992 GO:0140103 catalytic activity, acting on a glycoprotein 1/921 23/18639 0.0434782608695652 0.879903696360289 0.688461756445899 0.843528024701992 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/921 23/18639 0.0434782608695652 0.879903696360289 0.688461756445899 0.843528024701992 GO:0140767 enzyme-substrate adaptor activity 6/921 139/18639 0.0431654676258993 0.873573453940431 0.689364346582181 0.843639053120007 GO:0009378 four-way junction helicase activity 2/921 48/18639 0.0416666666666667 0.843241042345277 0.693427043690654 0.843642503974929 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/921 48/18639 0.0416666666666667 0.843241042345277 0.693427043690654 0.843642503974929 GO:0032266 phosphatidylinositol-3-phosphate binding 2/921 48/18639 0.0416666666666667 0.843241042345277 0.693427043690654 0.843642503974929 GO:0036121 double-stranded DNA helicase activity 2/921 48/18639 0.0416666666666667 0.843241042345277 0.693427043690654 0.843642503974929 GO:0043138 3'-5' DNA helicase activity 2/921 48/18639 0.0416666666666667 0.843241042345277 0.693427043690654 0.843642503974929 GO:0015078 proton transmembrane transporter activity 8/921 185/18639 0.0432432432432432 0.875147460163747 0.699763789803397 0.846441872529398 GO:0015149 hexose transmembrane transporter activity 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0015295 solute:proton symporter activity 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0019957 C-C chemokine binding 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0055056 D-glucose transmembrane transporter activity 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0070300 phosphatidic acid binding 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/921 24/18639 0.0416666666666667 0.843241042345277 0.703874665895476 0.846441872529398 GO:0015276 ligand-gated monoatomic ion channel activity 8/921 186/18639 0.043010752688172 0.870442366291899 0.705422629382602 0.847322672749738 GO:0008234 cysteine-type peptidase activity 8/921 187/18639 0.0427807486631016 0.865787594279643 0.71101183263301 0.853049993193646 GO:0004175 endopeptidase activity 18/921 405/18639 0.0444444444444444 0.899457111834962 0.712211249625641 0.853503446783208 GO:0004842 ubiquitin-protein transferase activity 20/921 449/18639 0.044543429844098 0.901460357072902 0.716089001189378 0.854753726692941 GO:0022834 ligand-gated channel activity 8/921 188/18639 0.0425531914893617 0.861182341118581 0.716531086702508 0.854753726692941 GO:0015271 outward rectifier potassium channel activity 1/921 25/18639 0.04 0.809511400651466 0.718525830693234 0.854753726692941 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/921 25/18639 0.04 0.809511400651466 0.718525830693234 0.854753726692941 GO:0003697 single-stranded DNA binding 5/921 121/18639 0.0413223140495868 0.836272108111018 0.719731730488947 0.854753726692941 GO:0015108 chloride transmembrane transporter activity 5/921 121/18639 0.0413223140495868 0.836272108111018 0.719731730488947 0.854753726692941 GO:0004725 protein tyrosine phosphatase activity 4/921 98/18639 0.0408163265306122 0.826032041481087 0.719835910352573 0.854753726692941 GO:0005249 voltage-gated potassium channel activity 4/921 98/18639 0.0408163265306122 0.826032041481087 0.719835910352573 0.854753726692941 GO:0016874 ligase activity 7/921 167/18639 0.0419161676646707 0.848290389904231 0.724096987198533 0.856950204658343 GO:0005048 signal sequence binding 2/921 51/18639 0.0392156862745098 0.793638628089672 0.724984821842814 0.856950204658343 GO:0016597 amino acid binding 2/921 51/18639 0.0392156862745098 0.793638628089672 0.724984821842814 0.856950204658343 GO:0016830 carbon-carbon lyase activity 2/921 51/18639 0.0392156862745098 0.793638628089672 0.724984821842814 0.856950204658343 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/921 122/18639 0.040983606557377 0.829417418700272 0.7264055506906 0.857653826326743 GO:0008157 protein phosphatase 1 binding 1/921 26/18639 0.0384615384615385 0.778376346780256 0.732452859270194 0.857969020047048 GO:0008198 ferrous iron binding 1/921 26/18639 0.0384615384615385 0.778376346780256 0.732452859270194 0.857969020047048 GO:0015145 monosaccharide transmembrane transporter activity 1/921 26/18639 0.0384615384615385 0.778376346780256 0.732452859270194 0.857969020047048 GO:0015216 purine nucleotide transmembrane transporter activity 1/921 26/18639 0.0384615384615385 0.778376346780256 0.732452859270194 0.857969020047048 GO:0051139 metal cation:proton antiporter activity 1/921 26/18639 0.0384615384615385 0.778376346780256 0.732452859270194 0.857969020047048 GO:0097602 cullin family protein binding 1/921 26/18639 0.0384615384615385 0.778376346780256 0.732452859270194 0.857969020047048 GO:0120014 phospholipid transfer activity 1/921 26/18639 0.0384615384615385 0.778376346780256 0.732452859270194 0.857969020047048 GO:0015293 symporter activity 6/921 146/18639 0.0410958904109589 0.831689795189862 0.733572698419079 0.858313100965566 GO:0004864 protein phosphatase inhibitor activity 2/921 53/18639 0.0377358490566038 0.76369000061459 0.744462436737322 0.866636995412049 GO:0008146 sulfotransferase activity 2/921 53/18639 0.0377358490566038 0.76369000061459 0.744462436737322 0.866636995412049 GO:0005385 zinc ion transmembrane transporter activity 1/921 27/18639 0.037037037037037 0.749547593195802 0.745691505195738 0.866636995412049 GO:0008395 steroid hydroxylase activity 1/921 27/18639 0.037037037037037 0.749547593195802 0.745691505195738 0.866636995412049 GO:0015252 proton channel activity 1/921 27/18639 0.037037037037037 0.749547593195802 0.745691505195738 0.866636995412049 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/921 27/18639 0.037037037037037 0.749547593195802 0.745691505195738 0.866636995412049 GO:0008509 monoatomic anion transmembrane transporter activity 6/921 149/18639 0.0402684563758389 0.814944363071945 0.751094683785122 0.871941202740494 GO:0015485 cholesterol binding 2/921 54/18639 0.037037037037037 0.749547593195802 0.753750125757232 0.873446245176687 GO:0015370 solute:sodium symporter activity 3/921 79/18639 0.0379746835443038 0.768523481631138 0.755426127031209 0.873446245176687 GO:0016835 carbon-oxygen lyase activity 3/921 79/18639 0.0379746835443038 0.768523481631138 0.755426127031209 0.873446245176687 GO:0050698 proteoglycan sulfotransferase activity 1/921 28/18639 0.0357142857142857 0.722778036295952 0.758275758565324 0.873446245176687 GO:0051119 sugar transmembrane transporter activity 1/921 28/18639 0.0357142857142857 0.722778036295952 0.758275758565324 0.873446245176687 GO:0051537 2 iron, 2 sulfur cluster binding 1/921 28/18639 0.0357142857142857 0.722778036295952 0.758275758565324 0.873446245176687 GO:0141052 histone H3 demethylase activity 1/921 28/18639 0.0357142857142857 0.722778036295952 0.758275758565324 0.873446245176687 GO:0001653 peptide receptor activity 5/921 128/18639 0.0390625 0.790538477198697 0.764041059592718 0.879112581303249 GO:0003785 actin monomer binding 1/921 29/18639 0.0344827586206897 0.697854655734022 0.770237932890257 0.882334302395785 GO:0004181 metallocarboxypeptidase activity 1/921 29/18639 0.0344827586206897 0.697854655734022 0.770237932890257 0.882334302395785 GO:0005416 amino acid:monoatomic cation symporter activity 1/921 29/18639 0.0344827586206897 0.697854655734022 0.770237932890257 0.882334302395785 GO:0035250 UDP-galactosyltransferase activity 1/921 29/18639 0.0344827586206897 0.697854655734022 0.770237932890257 0.882334302395785 GO:0019212 phosphatase inhibitor activity 2/921 56/18639 0.0357142857142857 0.722778036295952 0.771453651526632 0.882753682749087 GO:0016298 lipase activity 5/921 130/18639 0.0384615384615385 0.778376346780256 0.775679200105683 0.883668649479213 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/921 130/18639 0.0384615384615385 0.778376346780256 0.775679200105683 0.883668649479213 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/921 57/18639 0.0350877192982456 0.710097719869707 0.779882013086099 0.883668649479213 GO:0001965 G-protein alpha-subunit binding 1/921 30/18639 0.0333333333333333 0.674592833876221 0.78160874771068 0.883668649479213 GO:0008187 poly-pyrimidine tract binding 1/921 30/18639 0.0333333333333333 0.674592833876221 0.78160874771068 0.883668649479213 GO:0015215 nucleotide transmembrane transporter activity 1/921 30/18639 0.0333333333333333 0.674592833876221 0.78160874771068 0.883668649479213 GO:0031210 phosphatidylcholine binding 1/921 30/18639 0.0333333333333333 0.674592833876221 0.78160874771068 0.883668649479213 GO:0032452 histone demethylase activity 1/921 30/18639 0.0333333333333333 0.674592833876221 0.78160874771068 0.883668649479213 GO:0033612 receptor serine/threonine kinase binding 1/921 30/18639 0.0333333333333333 0.674592833876221 0.78160874771068 0.883668649479213 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/921 30/18639 0.0333333333333333 0.674592833876221 0.78160874771068 0.883668649479213 GO:0070566 adenylyltransferase activity 1/921 30/18639 0.0333333333333333 0.674592833876221 0.78160874771068 0.883668649479213 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 5/921 132/18639 0.0378787878787879 0.766582765768434 0.786872160835598 0.887200092694608 GO:0005496 steroid binding 4/921 108/18639 0.037037037037037 0.749547593195802 0.787085451308513 0.887200092694608 GO:0017116 single-stranded DNA helicase activity 2/921 58/18639 0.0344827586206897 0.697854655734022 0.788036600631281 0.887200092694608 GO:0051117 ATPase binding 3/921 84/18639 0.0357142857142857 0.722778036295952 0.791153612105623 0.887200092694608 GO:0016853 isomerase activity 7/921 180/18639 0.0388888888888889 0.787024972855592 0.791627598389074 0.887200092694608 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/921 31/18639 0.032258064516129 0.652831774718924 0.792417407142056 0.887200092694608 GO:0008327 methyl-CpG binding 1/921 31/18639 0.032258064516129 0.652831774718924 0.792417407142056 0.887200092694608 GO:0070273 phosphatidylinositol-4-phosphate binding 1/921 31/18639 0.032258064516129 0.652831774718924 0.792417407142056 0.887200092694608 GO:0140457 protein demethylase activity 1/921 31/18639 0.032258064516129 0.652831774718924 0.792417407142056 0.887200092694608 GO:0008378 galactosyltransferase activity 1/921 32/18639 0.03125 0.632430781758958 0.802691674555113 0.89292910774539 GO:0042910 xenobiotic transmembrane transporter activity 1/921 32/18639 0.03125 0.632430781758958 0.802691674555113 0.89292910774539 GO:0043425 bHLH transcription factor binding 1/921 32/18639 0.03125 0.632430781758958 0.802691674555113 0.89292910774539 GO:0051059 NF-kappaB binding 1/921 32/18639 0.03125 0.632430781758958 0.802691674555113 0.89292910774539 GO:0001098 basal transcription machinery binding 2/921 60/18639 0.0333333333333333 0.674592833876221 0.803550255767026 0.89292910774539 GO:0001099 basal RNA polymerase II transcription machinery binding 2/921 60/18639 0.0333333333333333 0.674592833876221 0.803550255767026 0.89292910774539 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/921 60/18639 0.0333333333333333 0.674592833876221 0.803550255767026 0.89292910774539 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/921 61/18639 0.0327868852459016 0.663533934960218 0.810922286494515 0.899940088890178 GO:0019239 deaminase activity 1/921 33/18639 0.0303030303030303 0.613266212614747 0.81245794357939 0.899940088890178 GO:0042923 neuropeptide binding 1/921 33/18639 0.0303030303030303 0.613266212614747 0.81245794357939 0.899940088890178 GO:0008175 tRNA methyltransferase activity 1/921 34/18639 0.0294117647058824 0.595228971067254 0.821741305611175 0.906507200488045 GO:0015035 protein-disulfide reductase activity 1/921 34/18639 0.0294117647058824 0.595228971067254 0.821741305611175 0.906507200488045 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/921 34/18639 0.0294117647058824 0.595228971067254 0.821741305611175 0.906507200488045 GO:0030246 carbohydrate binding 11/921 280/18639 0.0392857142857143 0.795055839925547 0.821876595630162 0.906507200488045 GO:0005154 epidermal growth factor receptor binding 1/921 35/18639 0.0285714285714286 0.578222429036761 0.830565613997744 0.911795197830563 GO:0005343 organic acid:sodium symporter activity 1/921 35/18639 0.0285714285714286 0.578222429036761 0.830565613997744 0.911795197830563 GO:0043015 gamma-tubulin binding 1/921 35/18639 0.0285714285714286 0.578222429036761 0.830565613997744 0.911795197830563 GO:0061631 ubiquitin conjugating enzyme activity 1/921 35/18639 0.0285714285714286 0.578222429036761 0.830565613997744 0.911795197830563 GO:0015294 solute:monoatomic cation symporter activity 4/921 116/18639 0.0344827586206897 0.697854655734022 0.83105876067906 0.911795197830563 GO:0019843 rRNA binding 2/921 65/18639 0.0307692307692308 0.622701077424204 0.837996049844394 0.915902033247328 GO:0120013 lipid transfer activity 2/921 65/18639 0.0307692307692308 0.622701077424204 0.837996049844394 0.915902033247328 GO:0000993 RNA polymerase II complex binding 1/921 36/18639 0.0277777777777778 0.562160694896851 0.83895354506139 0.915902033247328 GO:0004190 aspartic-type endopeptidase activity 1/921 36/18639 0.0277777777777778 0.562160694896851 0.83895354506139 0.915902033247328 GO:0052689 carboxylic ester hydrolase activity 3/921 92/18639 0.0326086956521739 0.659927772270217 0.839209562705925 0.915902033247328 GO:0030551 cyclic nucleotide binding 1/921 37/18639 0.027027027027027 0.546967162602342 0.846926656118664 0.92238657830953 GO:0070001 aspartic-type peptidase activity 1/921 37/18639 0.027027027027027 0.546967162602342 0.846926656118664 0.92238657830953 GO:0140097 catalytic activity, acting on DNA 13/921 336/18639 0.0386904761904762 0.783009539320614 0.852640194445133 0.927636818878004 GO:0042162 telomeric DNA binding 1/921 38/18639 0.0263157894736842 0.53257328990228 0.854505440642624 0.928693674505948 GO:0032934 sterol binding 2/921 68/18639 0.0294117647058824 0.595228971067254 0.855944851730637 0.929285998900869 GO:0008528 G protein-coupled peptide receptor activity 4/921 122/18639 0.0327868852459016 0.663533934960218 0.858845904673318 0.930491027065252 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/921 122/18639 0.0327868852459016 0.663533934960218 0.858845904673318 0.930491027065252 GO:0016758 hexosyltransferase activity 7/921 197/18639 0.0355329949238579 0.71910911225384 0.860121170160737 0.930901974788548 GO:0005267 potassium channel activity 4/921 124/18639 0.032258064516129 0.652831774718924 0.86719952481764 0.93456460419466 GO:0015036 disulfide oxidoreductase activity 1/921 40/18639 0.025 0.505944625407166 0.868556996857431 0.93456460419466 GO:0015144 carbohydrate transmembrane transporter activity 1/921 40/18639 0.025 0.505944625407166 0.868556996857431 0.93456460419466 GO:0061791 GTPase motor activity 1/921 40/18639 0.025 0.505944625407166 0.868556996857431 0.93456460419466 GO:1990606 membrane scission GTPase motor activity 1/921 40/18639 0.025 0.505944625407166 0.868556996857431 0.93456460419466 GO:0019842 vitamin binding 5/921 150/18639 0.0333333333333333 0.674592833876221 0.868902221031802 0.93456460419466 GO:0004812 aminoacyl-tRNA ligase activity 1/921 41/18639 0.024390243902439 0.493604512592357 0.875065895502213 0.935384223690123 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/921 41/18639 0.024390243902439 0.493604512592357 0.875065895502213 0.935384223690123 GO:0017080 sodium channel regulator activity 1/921 41/18639 0.024390243902439 0.493604512592357 0.875065895502213 0.935384223690123 GO:0042287 MHC protein binding 1/921 41/18639 0.024390243902439 0.493604512592357 0.875065895502213 0.935384223690123 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/921 41/18639 0.024390243902439 0.493604512592357 0.875065895502213 0.935384223690123 GO:0140318 protein transporter activity 1/921 41/18639 0.024390243902439 0.493604512592357 0.875065895502213 0.935384223690123 GO:0005319 lipid transporter activity 6/921 178/18639 0.0337078651685393 0.682172528638876 0.87880927800101 0.938420184833555 GO:0061659 ubiquitin-like protein ligase activity 14/921 372/18639 0.0376344086021505 0.761637070505411 0.884410923148154 0.942466131274261 GO:0015171 amino acid transmembrane transporter activity 3/921 102/18639 0.0294117647058824 0.595228971067254 0.885594850857335 0.942466131274261 GO:0000287 magnesium ion binding 8/921 230/18639 0.0347826086956522 0.703922957088231 0.886500049636891 0.942466131274261 GO:0003678 DNA helicase activity 2/921 74/18639 0.027027027027027 0.546967162602342 0.886500246484426 0.942466131274261 GO:0005245 voltage-gated calcium channel activity 1/921 43/18639 0.0232558139534884 0.470646163169457 0.887133663509362 0.942466131274261 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 6/921 181/18639 0.0331491712707182 0.670865801644861 0.888158855506514 0.942591471778619 GO:0005253 monoatomic anion channel activity 3/921 103/18639 0.029126213592233 0.589450049018058 0.889505577807883 0.943057444226929 GO:0016790 thiolester hydrolase activity 1/921 44/18639 0.0227272727272727 0.45994965946106 0.892723569720799 0.944541536598686 GO:0019205 nucleobase-containing compound kinase activity 1/921 44/18639 0.0227272727272727 0.45994965946106 0.892723569720799 0.944541536598686 GO:0061630 ubiquitin protein ligase activity 13/921 353/18639 0.0368271954674221 0.745300864622454 0.894086328502898 0.945021053219238 GO:0005179 hormone activity 4/921 132/18639 0.0303030303030303 0.613266212614747 0.896492367660514 0.945938959456834 GO:0005125 cytokine activity 8/921 234/18639 0.0341880341880342 0.691890086026894 0.896985696681995 0.945938959456834 GO:0003924 GTPase activity 12/921 331/18639 0.0362537764350453 0.733696133520966 0.897686057771356 0.945938959456834 GO:0004497 monooxygenase activity 3/921 106/18639 0.0283018867924528 0.572767500460943 0.900529183253098 0.947973476595714 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/921 46/18639 0.0217391304347826 0.439951848180144 0.903087358220288 0.949704215780243 GO:0046943 carboxylic acid transmembrane transporter activity 6/921 188/18639 0.0319148936170213 0.645886755838936 0.907618890535291 0.953504577619987 GO:0005342 organic acid transmembrane transporter activity 6/921 189/18639 0.0317460317460317 0.642469365596401 0.91014565743744 0.953978543597857 GO:0000049 tRNA binding 2/921 80/18639 0.025 0.505944625407166 0.910953717184641 0.953978543597857 GO:0008188 neuropeptide receptor activity 1/921 48/18639 0.0208333333333333 0.421620521172638 0.912450900775021 0.953978543597857 GO:0038187 pattern recognition receptor activity 1/921 48/18639 0.0208333333333333 0.421620521172638 0.912450900775021 0.953978543597857 GO:0015081 sodium ion transmembrane transporter activity 5/921 164/18639 0.0304878048780488 0.617005640740447 0.91266089734001 0.953978543597857 GO:0016763 pentosyltransferase activity 1/921 49/18639 0.0204081632653061 0.413016020740544 0.916788091909775 0.957329474868599 GO:0032813 tumor necrosis factor receptor superfamily binding 1/921 50/18639 0.02 0.404755700325733 0.920910639911448 0.960049235722118 GO:0005254 chloride channel activity 2/921 83/18639 0.0240963855421687 0.487657470271967 0.921240700688115 0.960049235722118 GO:0004527 exonuclease activity 2/921 84/18639 0.0238095238095238 0.481852024197301 0.9244135565072 0.96184958843656 GO:0005272 sodium channel activity 1/921 51/18639 0.0196078431372549 0.396819314044836 0.92482915627282 0.96184958843656 GO:0001664 G protein-coupled receptor binding 10/921 297/18639 0.0336700336700337 0.681406902905274 0.925745513413436 0.96184958843656 GO:0022843 voltage-gated monoatomic cation channel activity 4/921 143/18639 0.027972027972028 0.566091888567459 0.927434818745019 0.962642134541533 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/921 52/18639 0.0192307692307692 0.389188173390128 0.928553728420052 0.962841640547339 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/921 53/18639 0.0188679245283019 0.381845000307295 0.932093945567796 0.964587260403327 GO:0016860 intramolecular oxidoreductase activity 1/921 53/18639 0.0188679245283019 0.381845000307295 0.932093945567796 0.964587260403327 GO:0005244 voltage-gated monoatomic ion channel activity 5/921 173/18639 0.0289017341040462 0.584907081395568 0.933495335578143 0.96507627230417 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 1/921 54/18639 0.0185185185185185 0.374773796597901 0.935458923300071 0.965185522650222 GO:0017069 snRNA binding 1/921 54/18639 0.0185185185185185 0.374773796597901 0.935458923300071 0.965185522650222 GO:0022832 voltage-gated channel activity 5/921 175/18639 0.0285714285714286 0.578222429036761 0.937473834699311 0.966304875250579 GO:0030170 pyridoxal phosphate binding 1/921 56/18639 0.0178571428571429 0.361389018147976 0.94169739376529 0.968736229823897 GO:0170055 lipid transmembrane transporter activity 1/921 56/18639 0.0178571428571429 0.361389018147976 0.94169739376529 0.968736229823897 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/921 91/18639 0.021978021978022 0.444786483874432 0.943466519246194 0.96959615578318 GO:0070279 vitamin B6 binding 1/921 57/18639 0.0175438596491228 0.355048859934853 0.944586954134561 0.96978838472906 GO:0016757 glycosyltransferase activity 8/921 267/18639 0.0299625468164794 0.606375581012334 0.956187757371791 0.980729595172054 GO:0015079 potassium ion transmembrane transporter activity 4/921 160/18639 0.025 0.505944625407166 0.95912137034531 0.982768346931733 GO:0008173 RNA methyltransferase activity 1/921 67/18639 0.0149253731343284 0.302056492780398 0.966673822373739 0.988933922377927 GO:0016779 nucleotidyltransferase activity 3/921 136/18639 0.0220588235294118 0.446421728300441 0.967042218610177 0.988933922377927 GO:0140223 general transcription initiation factor activity 1/921 68/18639 0.0147058823529412 0.297614485533627 0.968326493577367 0.989273576034301 GO:0008028 monocarboxylic acid transmembrane transporter activity 1/921 70/18639 0.0142857142857143 0.289111214518381 0.971390269699611 0.991428772316204 GO:0004843 cysteine-type deubiquitinase activity 2/921 108/18639 0.0185185185185185 0.374773796597901 0.972532780016245 0.991620763922354 GO:0004521 RNA endonuclease activity 1/921 73/18639 0.0136986301369863 0.277229931729954 0.975439848672244 0.993347660334417 GO:0044183 protein folding chaperone 1/921 75/18639 0.0133333333333333 0.269837133550489 0.977816173982591 0.993347660334417 GO:0015085 calcium ion transmembrane transporter activity 3/921 147/18639 0.0204081632653061 0.413016020740544 0.978458906362419 0.993347660334417 GO:0051536 iron-sulfur cluster binding 1/921 76/18639 0.0131578947368421 0.26628664495114 0.978916761343183 0.993347660334417 GO:0101005 deubiquitinase activity 2/921 115/18639 0.0173913043478261 0.351961478544116 0.979711969972495 0.993347660334417 GO:0051540 metal cluster binding 1/921 77/18639 0.012987012987013 0.262828376834892 0.979962802543578 0.993347660334417 GO:0045182 translation regulator activity 10/921 356/18639 0.0280898876404494 0.568477107199063 0.983735593435218 0.995889746506898 GO:0004540 RNA nuclease activity 2/921 121/18639 0.0165289256198347 0.334508843244407 0.984387651263315 0.995889746506898 GO:0019783 ubiquitin-like protein peptidase activity 2/921 127/18639 0.015748031496063 0.318705275847034 0.988008955556562 0.998581035820299 GO:0005262 calcium channel activity 2/921 131/18639 0.0152671755725191 0.308973817042544 0.989953495526364 0.998625645984218 GO:0022836 gated channel activity 8/921 318/18639 0.0251572327044025 0.509126667076394 0.990083581428682 0.998625645984218 GO:0140101 catalytic activity, acting on a tRNA 2/921 139/18639 0.0143884892086331 0.291191151313477 0.99296337929229 0.998625645984218 GO:0004518 nuclease activity 4/921 209/18639 0.0191387559808612 0.38732602901984 0.99315214597291 0.998625645984218 GO:0046873 metal ion transmembrane transporter activity 12/921 450/18639 0.0266666666666667 0.539674267100977 0.994679503666273 0.998625645984218 GO:0005261 monoatomic cation channel activity 8/921 341/18639 0.0234604105571848 0.474786745250127 0.995191605926327 0.998625645984218 GO:0140098 catalytic activity, acting on RNA 9/921 387/18639 0.0232558139534884 0.470646163169457 0.997200514681798 0.998625645984218 GO:0030371 translation repressor activity 7/921 329/18639 0.0212765957446809 0.43059117055929 0.997329698725642 0.998625645984218 GO:0005216 monoatomic ion channel activity 11/921 448/18639 0.0245535714285714 0.496909899953467 0.997498621043079 0.998625645984218 GO:0004519 endonuclease activity 1/921 127/18639 0.0078740157480315 0.159352637923517 0.998432312562898 0.998625645984218 GO:0003735 structural constituent of ribosome 2/921 175/18639 0.0114285714285714 0.231288971614705 0.998625645984218 0.998625645984218