category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 3/7 116/9376 34.64039408867 PLCG2/ITGB1/ACTB 9.96489242799688 Organismal Systems Immune system hsa04611 Platelet activation 3/7 126/9376 31.891156462585 PLCG2/ITGB1/ACTB 9.54193847738207 NA NA hsa04518 Integrin signaling 3/7 154/9376 26.0927643784787 ITGB1/ACTB/COL4A1 8.58191776793781 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 3/7 203/9376 19.7945109078114 ITGB1/ACTB/COL4A1 7.39965359739915 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 3/7 204/9376 19.6974789915966 PLCG2/ITGB1/ACTB 7.37996247117927 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 3/7 233/9376 17.2458614347026 ITGB1/ACTB/COL4A1 6.86379626497954 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 2/7 51/9376 52.5266106442577 PLCG2/ACTB 10.0851017120803 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 3/7 253/9376 15.8825522303783 PLCG2/ITGB1/ACTB 6.55929067775092 NA NA hsa04517 IgSF CAM signaling 3/7 299/9376 13.439082656474 PLCG2/ITGB1/ACTB 5.97504002508658 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 2/7 78/9376 34.3443223443223 ITGB1/ACTB 8.08281176334407 Human Diseases Cardiovascular disease hsa05412 Arrhythmogenic right ventricular cardiomyopathy 2/7 86/9376 31.1495016611296 ITGB1/ACTB 7.67731827761062 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 2/7 89/9376 30.099518459069 ITGB1/COL4A1 7.53930167883495 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 2/7 93/9376 28.8049155145929 ITGB1/COL4A1 7.3655794352331 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 2/7 99/9376 27.0591630591631 ITGB1/ACTB 7.1246300961306 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 2/7 101/9376 26.5233380480905 PLCG2/COL4A1 7.04902805537723 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 2/7 105/9376 25.512925170068 ITGB1/ACTB 6.90421865913781 Organismal Systems Endocrine system hsa04919 Thyroid hormone signaling pathway 2/7 122/9376 21.9578454332553 PLCG2/ACTB 6.3686860362255 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 2/7 138/9376 19.4120082815735 ITGB1/ACTB 5.95579532545772 Cellular Processes Transport and catabolism hsa04145 Phagosome 2/7 155/9376 17.2829493087558 ITGB1/ACTB 5.58724798630041 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 2/7 170/9376 15.7579831932773 ITGB1/ACTB 5.30767137412373 Human Diseases Cancer: specific types hsa05225 Hepatocellular carcinoma 2/7 170/9376 15.7579831932773 PLCG2/ACTB 5.30767137412373 Organismal Systems Development and regeneration hsa04360 Axon guidance 2/7 184/9376 14.5590062111801 PLCG2/ITGB1 5.07714775103294 Organismal Systems Immune system hsa04613 Neutrophil extracellular trap formation 2/7 195/9376 13.7377289377289 PLCG2/ACTB 4.91306323024332 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 2/7 200/9376 13.3942857142857 ITGB1/ACTB 4.84281453758777 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 2/7 212/9376 12.6361185983827 ITGB1/ACTB 4.6840504925427 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 2/7 232/9376 11.5467980295567 ITGB1/ACTB 4.44615451929403 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 2/7 235/9376 11.3993920972644 ACTB/MT-ND3 4.41299127189757 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 2/7 333/9376 8.04461604461605 ITGB1/COL4A1 3.57776011015827 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 2/7 362/9376 7.40015785319653 ITGB1/COL4A1 3.39448764785385 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 2/7 368/9376 7.27950310559006 ACTB/MT-ND3 3.35910081945249 Environmental Information Processing Signal transduction hsa04370 VEGF signaling pathway 1/7 60/9376 22.3238095238095 PLCG2 4.52911886266227 Organismal Systems Immune system hsa04664 Fc epsilon RI signaling pathway 1/7 69/9376 19.4120082815735 PLCG2 4.19574309681397 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 1/7 70/9376 19.134693877551 ACTB 4.16261038629487 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 1/7 71/9376 18.8651911468813 PLCG2 4.13015824363711 Human Diseases Cancer: specific types hsa05223 Non-small cell lung cancer 1/7 73/9376 18.3483365949119 PLCG2 4.06720252147318 Organismal Systems Digestive system hsa04971 Gastric acid secretion 1/7 76/9376 17.6240601503759 ACTB 3.97731934187549 Human Diseases Cancer: specific types hsa05214 Glioma 1/7 76/9376 17.6240601503759 PLCG2 3.97731934187549 Metabolism Carbohydrate metabolism hsa00562 Inositol phosphate metabolism 1/7 78/9376 17.1721611721612 PLCG2 3.92020366199759 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 1/7 78/9376 17.1721611721612 ITGB1 3.92020366199759 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 1/7 78/9376 17.1721611721612 ITGB1 3.92020366199759 Human Diseases Drug resistance: antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance 1/7 80/9376 16.7428571428571 PLCG2 3.86516936950502 Environmental Information Processing Signal transduction hsa04012 ErbB signaling pathway 1/7 86/9376 15.5747508305648 PLCG2 3.71133832329232 Organismal Systems Immune system hsa04662 B cell receptor signaling pathway 1/7 91/9376 14.7189952904239 PLCG2 3.5945132419826 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 1/7 93/9376 14.4024577572965 ACTB 3.55033868694596 Organismal Systems Digestive system hsa04970 Salivary secretion 1/7 93/9376 14.4024577572965 CST3 3.55033868694596 Environmental Information Processing Signal transduction hsa04070 Phosphatidylinositol signaling system 1/7 98/9376 13.667638483965 PLCG2 3.44563724516159 Organismal Systems Immune system hsa04666 Fc gamma R-mediated phagocytosis 1/7 98/9376 13.667638483965 PLCG2 3.44563724516159 Organismal Systems Sensory system hsa04750 Inflammatory mediator regulation of TRP channels 1/7 99/9376 13.5295815295815 PLCG2 3.42561399439072 Organismal Systems Digestive system hsa04974 Protein digestion and absorption 1/7 103/9376 13.004160887656 COL4A1 3.34833057568948 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 1/7 103/9376 13.004160887656 COL4A1 3.34833057568948 Environmental Information Processing Signal transduction hsa04064 NF-kappa B signaling pathway 1/7 105/9376 12.756462585034 PLCG2 3.31128120295331 Organismal Systems Immune system hsa04625 C-type lectin receptor signaling pathway 1/7 105/9376 12.756462585034 PLCG2 3.31128120295331 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 1/7 110/9376 12.1766233766234 PLCG2 3.22291498675069 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 1/7 110/9376 12.1766233766234 FST 3.22291498675069 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 1/7 112/9376 11.9591836734694 ITGB1 3.18915760772773 Genetic Information Processing Chromosome hsa03082 ATP-dependent chromatin remodeling 1/7 117/9376 11.4481074481075 ACTB 3.10839754858698 Organismal Systems Nervous system hsa04722 Neurotrophin signaling pathway 1/7 120/9376 11.1619047619048 PLCG2 3.06226033567528 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 1/7 122/9376 10.9789227166276 PLCG2 3.03240263720604 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 1/7 130/9376 10.3032967032967 COL4A1 2.91957504015348 Organismal Systems Immune system hsa04650 Natural killer cell mediated cytotoxicity 1/7 133/9376 10.0708915145005 PLCG2 2.87976703259153 Cellular Processes Cell growth and death hsa04210 Apoptosis 1/7 137/9376 9.77685088633994 ACTB 2.82861968082782 Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 1/7 138/9376 9.70600414078675 MT-ND3 2.81616095170918 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 1/7 142/9376 9.43259557344065 PLCG2 2.76756957711514 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 1/7 142/9376 9.43259557344065 ACTB 2.76756957711514 Environmental Information Processing Signal transduction hsa04072 Phospholipase D signaling pathway 1/7 149/9376 8.98945349952061 PLCG2 2.68700197737182 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 1/7 149/9376 8.98945349952061 MT-ND3 2.68700197737182 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 1/7 154/9376 8.69758812615956 ACTB 2.63263414559512 Environmental Information Processing Signal transduction hsa04390 Hippo signaling pathway 1/7 157/9376 8.53139217470428 ACTB 2.60118487592619 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 1/7 160/9376 8.37142857142857 ITGB1 2.5705642222751 Human Diseases Infectious disease: viral hsa05164 Influenza A 1/7 173/9376 7.74236168455822 ACTB 2.44657438917815 Organismal Systems Immune system hsa04062 Chemokine signaling pathway 1/7 193/9376 6.940044411547 PLCG2 2.27910373649617 Cellular Processes Cell motility hsa04814 Motor proteins 1/7 194/9376 6.90427098674521 ACTB 2.27136297127317 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 1/7 196/9376 6.83381924198251 PLCG2 2.25604471111744 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 1/7 205/9376 6.53379790940767 PLCG2 2.18967629841921 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 1/7 205/9376 6.53379790940767 MT-ND3 2.18967629841921 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 1/7 214/9376 6.25901201602136 PLCG2 2.12717854892552 NA NA hsa04382 Cornified envelope formation 1/7 217/9376 6.1724818959842 COL4A1 2.10713739941738 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 1/7 227/9376 5.90056639395846 MT-ND3 2.04296266978105 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 1/7 238/9376 5.62785114045618 PLCG2 1.9766524786679 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 1/7 238/9376 5.62785114045618 PLCG2 1.9766524786679 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 1/7 248/9376 5.40092165898618 ACTB 1.91986062301137 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 1/7 254/9376 5.27334083239595 PLCG2 1.88724114217694 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 1/7 268/9376 4.99786780383795 MT-ND3 1.81498213300361 Human Diseases Neurodegenerative disease hsa05020 Prion disease 1/7 275/9376 4.87064935064935 MT-ND3 1.78071188785521 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 1/7 308/9376 4.34879406307978 MT-ND3 1.63341328051133 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 1/7 323/9376 4.1468376824414 PLCG2 1.5731400284236 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 1/7 388/9376 3.45213549337261 MT-ND3 1.34839406787352 NA NA hsa04519 Cadherin signaling 1/7 404/9376 3.31541725601132 ACTB 1.30035925931276 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 1/7 480/9376 2.79047619047619 MT-ND3 1.10072750937098