category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/209	233/9376	5.96866336735323	ITGB1/ACTB/COL4A2/COL4A1/FN1/COL6A1/SYNE2/TPM4/MYH9/TPM1/COL11A1/LMOD1/MYH10/ACTG1/SYNPO2/MYL9/VCL/TLN1/CSRP1/FBLN1/FHL1/FBLN2/DSP/PDLIM5/THBS1/FMNL2/SDC2/PDLIM7/COL6A3/SYNE3/LAMA2	11.5962705706454
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	27/209	203/9376	5.9667664458953	ITGB1/ACTB/COL4A2/COL4A1/FN1/COL6A1/CCND2/PDGFD/LAMC1/FLNA/HGF/LAMA4/ACTG1/MYL9/VCL/TLN1/PDGFRB/CAPN2/ACTN4/MYLK/THBS1/IGF1R/MYL12A/COL6A3/TNXB/BCL2/LAMA2	10.8021754353593
NA	NA	hsa04518	Integrin signaling	23/209	154/9376	6.70005592493631	ITGB1/ACTB/COL4A2/COL4A1/FN1/COL6A1/CCND2/ARHGEF6/PDGFD/LAMC1/FLNA/HGF/LAMA4/ACTG1/VCL/TLN1/PDGFRB/ACTN4/THBS1/IGF1R/COL6A3/TNXB/LAMA2	10.7689183398686
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/209	362/9376	3.59385656506913	ITGB1/COL4A2/COL4A1/FN1/COL6A1/CCND2/IRS1/PDGFD/LAMC1/HGF/LAMA4/IFNAR1/CREB3L1/PDGFRB/IGF2/THBS1/CDK6/IGF1R/PRLR/GNG11/COL6A3/TNXB/YWHAZ/BCL2/OSMR/IL6R/EIF4B/IL4R/LAMA2	7.59952819826139
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/209	204/9376	4.17825311942959	PLCG2/ITGB1/ACTB/FN1/GPC3/WNT2/FLNA/HGF/ACTG1/TGFB2/MMP2/PLAU/HIF1A/ITPR2/IGF2/THBS1/SDC2/IGF1R/EIF4B	6.92973629421168
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	20/209	253/9376	3.54634340072243	PLCG2/ITGB1/ACTB/ARPC5/ACTG1/MYL9/VCL/TLN1/CAST/CD14/CAPN2/ACTN4/IL1R1/TIFA/ITPR2/SQSTM1/MYL12A/CYTH3/BCL2/CBX3	6.19945570186746
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/209	101/9376	5.33004879435312	PLCG2/COL4A2/COL4A1/FN1/TGFB2/MMP2/PIM1/THBD/TGFBR1/F3/BCL2/TGFB3	6.60604737172758
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/209	103/9376	5.22655270125888	COL4A2/COL4A1/FN1/LAMC1/LAMA4/TGFB2/VCL/CD14/ACTN4/IL1R1/TGFB3/LAMA2	6.51238304051598
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/209	89/9376	5.54464813719693	ITGB1/COL4A2/COL4A1/FN1/COL6A1/LAMC1/LAMA4/THBS1/COL6A3/TNXB/LAMA2	6.50433214322421
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/209	112/9376	4.80656185919344	ITGB1/LAMC1/LAMA4/TGFB2/HLA-DRA/GNAI1/HSPA1A/HLA-DPB1/BCL2/TGFB3/IFNGR2/LAMA2	6.1191034502251
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	17/209	232/9376	3.28724632898862	ITGB1/ACTB/FN1/IQGAP2/ARPC5/ARHGEF6/PDGFD/MYH9/MYH10/ACTG1/MYL9/VCL/PDGFRB/ACTN4/MYLK/CFL2/MYL12A	5.32640258471678
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	21/209	333/9376	2.82908746066641	ITGB1/COL4A2/COL4A1/FN1/COL6A1/WNT2/CCND2/LAMC1/LAMA4/MAML2/IFNAR1/CREB3L1/PDGFRB/DLG3/THBS1/CDK6/JAG1/COL6A3/TNXB/CHD4/LAMA2	5.13151366031245
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/209	168/9376	3.7384370015949	IL6ST/CCND2/CISH/IFNAR1/FHL1/PDGFRB/PIM1/PRLR/SOCS2/BCL2/OSMR/IL6R/IL4R/IFNGR2	5.40779108458857
NA	NA	hsa04517	IgSF CAM signaling	19/209	299/9376	2.85071450288842	PLCG2/ITGB1/ACTB/ARPC5/MYH9/MYH10/ACTG1/MYL9/NRP1/VCL/TJP1/CADM3/NFASC/ACTN4/MYLK/MBP/SLIT2/EPB41L2/MYL12A	4.9107635120723
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/209	93/9376	4.82378967947729	ACTB/ACTG1/MYL9/VCL/TJP1/ACTN4/IGF1R/TGFBR1/MYL12A/HEG1	5.59546857890175
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/209	116/9376	4.2540834845735	PLCG2/ITGB1/ACTB/ACTG1/MYL9/VCL/MMP2/ACTN4/GNAI1/MYL12A/CYBA	5.32472713807276
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/209	170/9376	3.43056571911061	PLCG2/ACTB/WNT2/HGF/ACTG1/TGFB2/IGF2/CDK6/IGF1R/TGFBR1/BRD7/TXNRD1/TGFB3	4.82882547508546
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/209	50/9376	6.28057416267943	HGF/TGFB2/LRP1/HBA2/THBS1/SDC2/TGFB3	5.65279985057284
Organismal Systems	Immune system	hsa04611	Platelet activation	11/209	126/9376	3.91645781119465	PLCG2/ITGB1/ACTB/ACTG1/TLN1/MYLK/ITPR2/SNAP23/GNAI1/MYL12A/APBB1IP	4.97639987127144
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/209	109/9376	4.11571046047145	IL6ST/HLA-DRA/IL1R1/HIF1A/TGFBR1/AHR/HLA-DPB1/IL6R/IL4R/IFNGR2	4.94021585788689
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/209	93/9376	4.34141071152956	ITGB1/COL4A2/COL4A1/FN1/LAMC1/LAMA4/CDK6/BCL2/LAMA2	4.88958865753444
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/209	99/9376	4.0782949108308	ITGB1/ACTB/TPM4/SLC8A1/TPM1/ACTG1/TGFB2/TGFB3/LAMA2	4.64910343798666
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/209	170/9376	3.16667604840979	ITGB1/ACTB/ARPC5/MYH9/MYH10/ACTG1/MYL9/TJP1/CFTR/ACTN4/DLG3/MYL12A	4.3045536339775
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/209	105/9376	3.84524948735475	ITGB1/ACTB/TPM4/SLC8A1/TPM1/ACTG1/TGFB2/TGFB3/LAMA2	4.42687111840424
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/209	66/9376	4.7580107293026	TGFB2/HLA-DRA/MAF/HLA-DPB1/IL4R/TGFB3/IFNGR2	4.62594333431273
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	17/209	323/9376	2.36111810627046	PLCG2/CCND2/IRS1/FSCN1/TPM1/TGFB2/MARCKS/PDGFRB/PIM1/PLAU/THBS1/ZEB2/CDK6/GLS/TNXB/BCL2/IRS2	3.75877195460671
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/209	76/9376	4.13195668597331	ACTB/ACTG1/CFTR/MYLK/ITPR2/GNAI1/SLC4A2	4.13929362589758
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/209	122/9376	3.30943603419876	PLCG2/IRS1/IGFBP3/CREB3L1/ITPR2/GNAI1/SSTR1/SOCS2/IRS2	3.87673639254915
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/209	78/9376	4.02600907864066	ITGB1/ACTB/FN1/ARPC5/ACTG1/VCL/CLTC	4.05198587405284
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/209	78/9376	4.02600907864066	ITGB1/TGFB2/HLA-DRA/HLA-DPB1/CYBA/TGFB3/IFNGR2	4.05198587405284
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/209	80/9376	3.92535885167464	PLCG2/PDGFD/HGF/PDGFRB/IGF1R/BCL2/IL6R	3.96753941447316
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	12/209	205/9376	2.62602404014471	MT-ND3/IRS1/TGFB2/CTSD/MT-ATP8/MMP2/MT-ND4L/TGFBR1/NDUFB10/CYBA/TGFB3/MT-CO2	3.554190580652
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/209	157/9376	2.85740407765215	CCND2/TGFB2/IGFBP3/CAPN2/ITPR2/SQSTM1/CDK6/TGFBR1/RBBP4/TGFB3	3.54372064693553
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/209	157/9376	2.85740407765215	ACTB/WNT2/CCND2/ACTG1/TGFB2/DLG3/TGFBR1/YAP1/YWHAZ/TGFB3	3.54372064693553
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/209	184/9376	2.68192219679634	PLCG2/ITGB1/DPYSL2/MYL9/NRP1/CFL2/SLIT2/SEMA6D/SEMA3C/GNAI1/MYL12A	3.47900434669475
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/209	110/9376	3.26263592866464	PLCG2/PFKP/HIF1A/IGF1R/EPAS1/BCL2/IL6R/IFNGR2	3.60420960153589
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/209	88/9376	3.56850804697695	SERPINE2/PLAU/SERPING1/CD46/THBD/F3/C1QA	3.65515946614906
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/209	142/9376	2.84331828290316	PLCG2/TGFB2/IFNAR1/IL1R1/ITPR2/SQSTM1/TGFBR1/CYBA/IFNGR2	3.34190987267966
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/209	142/9376	2.84331828290316	ACTB/ACTG1/MMP2/IL1R1/SQSTM1/SDC2/THBD/BCL2/CYBA	3.34190987267966
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/209	93/9376	3.3766527756341	MAML2/HLA-DRA/MAF/JAG1/HLA-DPB1/IL4R/IFNGR2	3.47782881479981
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/209	51/9376	4.39816117834694	PLCG2/ACTB/ACTG1/TJP1/CFTR	3.6740901432725
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/209	298/9376	2.10757522237565	IL6ST/TGFB2/IFNAR1/IL1R1/TGFBR1/IL1RL1/PRLR/OSMR/IL6R/IL4R/TGFB3/IFNGR2/CCL4L2/IL32	2.93380632118806
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/209	100/9376	3.14028708133971	HLA-DRA/CD14/IL1R1/HLA-DPB1/CD9/IL6R/IL4R	3.24890360274029
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/209	78/9376	3.45086492454914	ITGB1/CD14/SERPING1/CFL2/GNAI1/C1QA	3.28183749466667
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/209	155/9376	2.60484642691773	ITGB1/ACTB/ACTG1/DYNC1I2/HLA-DRA/CD14/THBS1/HLA-DPB1/CYBA	3.04197389857876
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/209	212/9376	2.32770605759682	ITGB1/ACTB/PDGFD/HGF/ACTG1/TLN1/PDGFRB/THBS1/IGF1R/GNAI1/APBB1IP	2.95238161676077
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/209	130/9376	2.76069193963931	COL4A2/COL4A1/ACTA2/MMP2/CREB3L1/TGFBR1/GNAI1/GNG11	3.05227228491834
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/209	133/9376	2.69842069288053	CCND2/IRS1/TGFB2/IGF1R/TGFBR1/GABARAP/TGFB3/IRS2	2.97858351799851
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/209	194/9376	2.31243525871849	ACTB/TPM4/MYH9/TPM1/MYH10/ACTG1/MYL9/ACTA2/DYNC1I2/MYL12A	2.78904342082571
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/209	166/9376	2.43223612151957	IRS1/SLC8A1/MYL9/CREB3L1/MYLK/ITPR2/GNAI1/PDE3A/IRS2	2.81114998300876
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/209	86/9376	3.1298542338934	ITGB1/ACTB/SLC8A1/ACTG1/DSP/LAMA2	2.99596279463391
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/209	139/9376	2.58194210182094	CTSD/MMP2/CREB3L1/KRT18/ITPR2/GNAI1/HSPA1A/BCL2	2.83711982449766
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/209	140/9376	2.5634996582365	SLC8A1/ACTA2/MYLK/ITPR2/TGFBR1/GNAI1/GNG11/JAG1	2.81426514510301
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/209	169/9376	2.38906033238017	IRS1/CTSD/HIF1A/SQSTM1/IGF1R/OPTN/BCL2/GABARAP/IRS2	2.75137987044998
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/209	300/9376	1.94398724082935	PDGFD/FLNA/HGF/TGFB2/PDGFRB/CD14/IL1R1/IGF2/IGF1R/TGFBR1/HSPA1A/MAPT/TGFB3	2.50913872748932
NA	NA	hsa04519	Cadherin signaling	16/209	404/9376	1.77668293145104	ACTB/PCDH10/WNT2/ARPC5/LIMA1/ACTG1/CDH11/VCL/TJP1/KRT18/PDGFRB/DSP/ACTN4/IGF1R/YAP1/YWHAZ	2.40954464111348
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/209	70/9376	3.20437457279563	HGF/TGFB2/HIF1A/EPAS1/TGFB3	2.79510453172894
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/209	70/9376	3.20437457279563	ACTB/ACTG1/HLA-DRA/HLA-DPB1/LAMA2	2.79510453172894
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	9/209	181/9376	2.23066959211187	TGFB2/CTSD/CD74/HLA-DRA/CD14/HLA-DPB1/BCL2/TGFB3/IFNGR2	2.52435282924627
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	11/209	248/9376	1.98981324278438	ACTB/ARPC5/FLNA/ACTG1/MYL9/DYNC1I2/AHNAK/CD14/MYL12A/CYTH3/BCL2	2.38526398185517
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/209	73/9376	3.07268794651635	PDGFD/HGF/PDGFRB/CDK6/IGF1R	2.68428736391609
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/209	158/9376	2.27145539337411	CCND2/TGFB2/CDKN1C/CDK6/WEE1/YWHAZ/RAD21/TGFB3	2.4336408438012
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/209	75/9376	2.99074960127592	CCND2/IGFBP3/THBS1/CDK6/BCL2	2.6135307395508
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/209	76/9376	2.95139763283808	PLCG2/PDGFRB/CAMK1D/CDK6/IGF1R	2.57902921179387
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/209	103/9376	2.61327635062944	COL4A2/COL4A1/COL6A1/SLC8A1/COL11A1/COL6A3	2.48577843176435
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/209	103/9376	2.61327635062944	TGFB2/TGFBR1/GNAI1/C1QA/TGFB3/IFNGR2	2.48577843176435
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	10/209	224/9376	2.00273410799727	CCND2/TGFB2/NRP1/TLN1/CREB3L1/HLA-DRA/IL1R1/TGFBR1/HLA-DPB1/TGFB3	2.29349055907053
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/209	77/9376	2.91306779345057	ARHGEF6/TGFB2/CDK6/TGFBR1/TGFB3	2.54508777405184
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/209	105/9376	2.5634996582365	PLCG2/CD14/IL1R1/PLAU/BCL2/CCL4L2	2.43262023644786
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/209	106/9376	2.53931569919653	PDGFD/CREB3L1/PDGFRB/PLAU/IGF1R/BCL2	2.40650035360415
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/209	200/9376	2.01875598086124	ITGB1/ACTB/ARPC5/MYH9/MYH10/ACTG1/TJP1/IL1R1/CYTH3	2.19889064877412
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/209	110/9376	2.44697694649848	FMOD/TGFB2/FST/THBS1/TGFBR1/TGFB3	2.30492592188652
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	11/209	275/9376	1.79444976076555	MT-ND3/LAMC1/MT-ATP8/CREB3L1/MT-ND4L/ITPR2/HSPA1A/NDUFB10/CYBA/C1QA/MT-CO2	2.01898640178755
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/209	89/9376	2.52029460781678	PDGFD/TJP1/PDGFRB/ITPR2/GNAI1	2.17585625691415
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/209	89/9376	2.52029460781678	TRAK2/GLS/GNAI1/GNG11/GABARAP	2.17585625691415
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/209	62/9376	2.89427380768637	IRS1/IGF1R/HSPA1A/IRS2	2.25951718006186
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/209	17/9376	5.27779341401632	INMT/TXNRD1	2.66547559283476
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/209	17/9376	5.27779341401632	MYH9/MYH10	2.66547559283476
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/209	122/9376	2.20629068946584	IRS1/PFKP/CFTR/CREB3L1/IGF1R/IRS2	2.02494069833282
NA	NA	hsa04081	Hormone signaling	9/209	219/9376	1.84361276790981	IRS1/SLC40A1/IGF2/IGF1R/GNAI1/PRLR/GNG11/SSTR1/IRS2	1.90736478428254
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/209	154/9376	2.0391474554154	ACTB/ACTG1/MYL9/MYLK/CAMK1D/ITPR2/GNAI1	1.96322531529825
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/209	227/9376	1.77863963071475	MT-ND3/HGF/MT-ATP8/MT-ND4L/HIF1A/AHR/NDUFB10/CYBA/MT-CO2	1.79311351854029
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/209	163/9376	1.92655649161946	TGFB2/IFNAR1/CREB3L1/TGFBR1/YWHAZ/BCL2/TGFB3	1.80181556953762
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/209	71/9376	2.52739402924725	CCND2/CISH/PRLR/SOCS2	1.95059559792278
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/209	71/9376	2.52739402924725	PFKP/PDGFRB/HIF1A/GLS	1.95059559792278
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/209	45/9376	2.99074960127592	ABCA8/CFTR/ABCC9	2.0211752204832
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/209	134/9376	2.00871241876741	MYH9/MYH10/MYL9/ACTA2/MYLK/ITPR2	1.77575051930796
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/209	73/9376	2.45815035721308	PLCG2/HGF/EML4/CDK6	1.88841479255736
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/209	136/9376	1.97917253025612	CCND2/IFNAR1/CD46/CDK6/HSPA1A/BCL2	1.73675219093069
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/209	137/9376	1.96472601543673	ACTB/ACTG1/CTSD/CAPN2/ITPR2/BCL2	1.71750083058551
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/209	75/9376	2.39259968102073	SLC26A4/CREB3L1/ITPR2/GPX3	1.82825709064747
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/209	47/9376	2.86348366079609	IRS1/SOCS2/IRS2	1.93375806137521
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/209	205/9376	1.7506826934298	IL6ST/CCND2/CREB3L1/ACTN4/HDAC9/CDK6/YWHAZ/CHD4	1.64085480421879
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/209	173/9376	1.81519484470504	ACTB/ACTG1/IFNAR1/HLA-DRA/CDK6/HLA-DPB1/IFNGR2	1.63404845495485
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/209	77/9376	2.33045423476046	TGFB2/CDK6/TGFBR1/TGFB3	1.769996242902
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	13/209	388/9376	1.50308291816702	MT-ND3/WNT2/IRS1/MT-ATP8/LPL/LRP1/MT-ND4L/CAPN2/ITPR2/NDUFB10/MAPT/IRS2/MT-CO2	1.52816084516117
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/209	214/9376	1.67705585118276	PLCG2/ITPR2/CFL2/GNAI1/GNG11/WEE1/BCL2/SAMHD1	1.51279961110145
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/209	82/9376	2.18835336678726	CD74/HLA-DRA/HSPA1A/HLA-DPB1	1.63191058221761
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/209	115/9376	1.95048887039734	CREB3L1/ITPR2/GNAI1/GNG11/BCL2	1.54850345820001
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/209	254/9376	1.58957163847342	PLCG2/PDGFD/SLC8A1/HGF/PDGFRB/PTGFR/MYLK/CAMK1D/ITPR2	1.4383135551875
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/209	149/9376	1.80649304775055	MT-ND3/MT-ND4L/ITPR2/GNAI1/GNG11/NDUFB10	1.49833411339985
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/209	150/9376	1.79444976076555	WNT2/HGF/TGFB2/TGFBR1/BCL2/TGFB3	1.48098448415438
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/209	117/9376	1.91714718030508	ACTB/ACTG1/BRD7/CHD4/RBBP4	1.50728400179119
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	12/209	368/9376	1.462866652798	ACTB/MT-ND3/ACTG1/MT-ATP8/MT-ND4L/SQSTM1/GPX3/OPTN/ANXA11/NDUFB10/BCL2/MT-CO2	1.36776277355915
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/209	187/9376	1.67929790445974	IFNAR1/ANTXR2/ITPR2/BCL2/CYBA/GBP1/GABARAP	1.41674640059253
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/209	87/9376	2.06258593191443	TPM4/SLC8A1/TPM1/MT-CO2	1.50343401621567
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/209	87/9376	2.06258593191443	TGFB2/TGFBR1/BCL2/TGFB3	1.50343401621567
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/209	154/9376	1.74784067607034	TPM4/SLC8A1/TPM1/CREB3L1/GNAI1/BCL2	1.4128695012626
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/209	155/9376	1.73656428461182	WNT2/CREB3L1/ITPR2/CDK6/GNAI1/AHR	1.39615186277843
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/209	227/9376	1.58101300507978	CREB3L1/IL1R1/ITPR2/CDK6/GNAI1/GNG11/IL6R/CCL4L2	1.33800314389332
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/209	122/9376	1.83857557455487	PLCG2/ACTB/ACTG1/PFKP/HIF1A	1.40767546692738
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/209	90/9376	1.99383306751728	IRS1/CREB3L1/IGF1R/IRS2	1.43042642160064
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/209	59/9376	2.28108020436299	IRS1/GNAI1/IRS2	1.49042265729531
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/209	160/9376	1.6822966507177	ITGB1/HLA-DRA/CADM3/NFASC/SDC2/HLA-DPB1	1.31433829936445
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	7/209	196/9376	1.60218728639781	PLCG2/IL6ST/IFNAR1/HIF1A/ITPR2/CDK6/GNG11	1.28642195350677
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/209	60/9376	2.24306220095694	ITPR2/IGF1R/GNAI1	1.45847473896348
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	8/209	235/9376	1.52719128575792	ACTB/MT-ND3/ACTG1/MT-ATP8/CREB3L1/MT-ND4L/NDUFB10/MT-CO2	1.23580647165445
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/209	61/9376	2.20629068946584	SLC8A1/SLC40A1/MT1F	1.42715331055486
Human Diseases	Immune disease	hsa05310	Asthma	2/209	32/9376	2.80382775119617	HLA-DRA/HLA-DPB1	1.54329448401681
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/209	95/9376	1.88889448501637	TGFB2/HLA-DRA/HLA-DPB1/TGFB3	1.31480029725355
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/209	201/9376	1.56233188126354	PROM1/CCND2/IGFBP3/CD14/MAF/PLAU/IGF1R	1.21683828197696
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	8/209	238/9376	1.50794097543324	PLCG2/RPS4Y1/IL6ST/NRP1/IFNAR1/RPS21/IL6R/C1QA	1.19845385271349
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/209	205/9376	1.53184735675108	PLCG2/CCND2/IFNAR1/HLA-DRA/CDK6/HLA-DPB1/BCL2	1.16252086011049
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/209	98/9376	1.83107118445464	PLCG2/ARPC5/MARCKS/CFL2	1.24873200754167
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/209	133/9376	1.68651293305033	CREB3L1/ITPR2/GNAI1/GNG11/COMT	1.20396325589303
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/209	99/9376	1.8125755159248	MMP2/IGF1R/JAG1/BCL2	1.2272208265095
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/209	99/9376	1.8125755159248	HLA-DRA/KRT18/HLA-DPB1/C1QA	1.2272208265095
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/209	36/9376	2.4922913343966	GALNT15/GALNT1	1.35449246975305
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/209	138/9376	1.62540739199778	MT-ND3/MT-ATP8/MT-ND4L/NDUFB10/MT-CO2	1.11752884036761
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/209	138/9376	1.62540739199778	ITGB1/ACTB/FN1/ARPC5/ACTG1	1.11752884036761
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	8/209	250/9376	1.43555980861244	ARPC5/RAB11FIP1/IGF1R/TGFBR1/CYTH3/HSPA1A/PSD3/CLTC	1.053956619917
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/209	69/9376	1.95048887039734	ITPR2/GNAI1/PDE3A	1.19649776006988
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/209	37/9376	2.42493210914264	LAMA4/HBA2	1.31126362177954
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/209	105/9376	1.70899977215767	HIF1A/SQSTM1/OPTN/GABARAP	1.10311964847694
NA	NA	hsa04382	Cornified envelope formation	7/209	217/9376	1.44713690384319	COL4A2/COL4A1/DST/TJP1/KRT18/DSP/PPL	1.0062166937349
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/209	180/9376	1.49537480063796	IFNAR1/CD74/HLA-DRA/HLA-DPB1/BCL2/IFNGR2	1.01324821514121
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/209	39/9376	2.30057661636609	HLA-DRA/HLA-DPB1	1.228880721308
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/209	41/9376	2.18835336678726	MMP2/THBS1	1.15139816700494
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/209	12/9376	3.7384370015949	CD46	1.43320343513416
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/209	149/9376	1.50541087312546	PLCG2/PDGFD/PDGFRB/PTGFR/CYTH3	0.938971953446155
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/209	42/9376	2.13624971519708	INMT/HAAO	1.11431942140941
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/209	42/9376	2.13624971519708	SLC40A1/GPX4	1.11431942140941
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	8/209	268/9376	1.3391416125116	MT-ND3/MT-ATP8/MT-ND4L/ITPR2/GNAI1/NDUFB10/MAPT/MT-CO2	0.850515303544795
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/209	308/9376	1.31088050705276	MT-ND3/MT-ATP8/CREB3L1/MT-ND4L/GPX3/POLR2L/NDUFB10/CLTC/MT-CO2	0.837641642477782
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/209	115/9376	1.56039109631787	CREB3L1/ITPR2/GNAI1/BCL2	0.91296971234388
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/209	44/9376	2.0391474554154	HLA-DRA/HLA-DPB1	1.04318496048353
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/209	44/9376	2.0391474554154	DYNC1I2/CREB3L1	1.04318496048353
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/209	116/9376	1.54693944893582	ITPR2/GLS/GNAI1/GNG11	0.894968841591603
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/209	45/9376	1.99383306751728	HLA-DRA/HLA-DPB1	1.00902231404457
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/209	14/9376	3.20437457279563	B3GNT2	1.24626459643253
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/209	157/9376	1.42870203882608	IRS1/NDUFB10/IL6R/IRS2/MT-CO2	0.817915866908004
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	13/209	480/9376	1.21499202551834	MT-ND3/WNT2/MT-ATP8/MT-ND4L/CAPN2/ITPR2/SQSTM1/GPX3/OPTN/NDUFB10/BCL2/MAPT/MT-CO2	0.730114121651913
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/209	238/9376	1.31944835350408	PLCG2/PDGFD/HGF/PDGFRB/IGF2/IGF1R/GNG11	0.753717712325549
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/209	47/9376	1.90898910719739	ACSS1/ME3	0.943268272604166
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/209	83/9376	1.62149074767971	AUTS2/CBX3/RBBP4	0.858698908268285
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/209	83/9376	1.62149074767971	POLR2L/SAMHD1/CCL4L2	0.858698908268285
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/209	49/9376	1.83107118445464	GALNT15/GALNT1	0.880664401667308
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/209	49/9376	1.83107118445464	CREB3L1/GNAI1	0.880664401667308
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/209	50/9376	1.79444976076555	HLA-DRA/HLA-DPB1	0.850450225788405
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/209	51/9376	1.75926447133877	PAFAH1B2/LPCAT2	0.820916361489312
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/209	168/9376	1.33515607199818	IFNAR1/CAPN2/SQSTM1/BCL2/IFNGR2	0.661857116684399
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/209	52/9376	1.72543246227457	LPL/LRP1	0.792031931333691
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/209	250/9376	1.25611483253589	CTSD/PSAP/CTSA/VPS13C/TPP1/BLOC1S1/CLTC	0.61974020070873
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/209	90/9376	1.49537480063796	EML4/HIF1A/IFNGR2	0.712994190460831
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/209	91/9376	1.47894211052106	GNAI1/GNG11/PDE3A	0.693199006083399
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/209	53/9376	1.69287713279769	SLC8A1/CLTC	0.763768049522423
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/209	54/9376	1.6615275562644	HLA-DRA/HLA-DPB1	0.736097657806796
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/209	93/9376	1.44713690384319	CST3/ITPR2/SLC4A2	0.654309129330559
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/209	56/9376	1.60218728639781	CCND2/BCL2	0.682437377210729
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/209	56/9376	1.60218728639781	CD14/HSPA1A	0.682437377210729
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/209	138/9376	1.30032591359822	IRS1/SOCS2/FLOT1/IRS2	0.536646790955994
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/209	98/9376	1.37330338834098	CREB3L1/CAMK1D/ITPR2	0.560909700955448
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/209	21/9376	2.13624971519708	DSEL	0.787057939774975
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/209	99/9376	1.3594316369436	PLCG2/IL1R1/ITPR2	0.54284430421407
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/209	99/9376	1.3594316369436	PDGFD/PDGFRB/HIF1A	0.54284430421407
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/209	59/9376	1.52072013624199	GPX4/GPX3	0.605811475754459
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/209	100/9376	1.34583732057416	IL6ST/IL6R/CCL4L2	0.524972620061854
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/209	226/9376	1.19100647838421	MYL9/CFTR/CREB3L1/GNAI1/SSTR1/PDE3A	0.438871051962758
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/209	101/9376	1.33251219858828	WNT2/CREB3L1/GNAI1	0.507290203846218
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/209	143/9376	1.25485997256332	HLA-DRA/ACTN4/HLA-DPB1/C1QA	0.463706729447437
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/209	102/9376	1.31944835350408	CFTR/ITPR2/SLC4A2	0.489792758333988
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/209	62/9376	1.44713690384319	MAML2/JAG1	0.533351362392178
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/209	23/9376	1.95048887039734	GLS	0.689097465120273
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/209	23/9376	1.95048887039734	CTSA	0.689097465120273
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/209	23/9376	1.95048887039734	GLS	0.689097465120273
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/209	148/9376	1.21246605457132	WNT2/CDK6/IGF1R/JAG1	0.393379554003586
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/209	65/9376	1.38034596981965	CREB3L1/ITPR2	0.464603523770642
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/209	107/9376	1.25779188838707	PFKP/CREB3L1/ITPR2	0.404939237899211
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/209	109/9376	1.23471313814143	IFNAR1/CD14/CCL4L2	0.372157035068417
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/209	109/9376	1.23471313814143	IRS1/CREB3L1/IRS2	0.372157035068417
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/209	195/9376	1.15028830818305	PLCG2/ACTB/ACTG1/HDAC9/CYBA	0.320215738195866
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/209	67/9376	1.3391416125116	PFKP/ACSS1	0.420641514623037
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/209	26/9376	1.72543246227457	SLC19A3	0.559271926736805
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/209	68/9376	1.31944835350408	PIM1/CD14	0.399183046829839
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/209	70/9376	1.28174982911825	IRS1/IRS2	0.357253360613541
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/209	157/9376	1.14296163106086	LRP1/HIF1A/THBS1/C1QA	0.272754910902499
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/209	28/9376	1.60218728639781	B3GNT2	0.481832856698713
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/209	158/9376	1.13572769668706	WNT2/IRS1/IGF1R/EIF4B	0.259790841278449
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/209	71/9376	1.26369701462363	PLCG2/TJP1	0.336760669520046
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/209	115/9376	1.1702933222384	ITPR2/GNAI1/GNG11	0.27743596648775
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/209	29/9376	1.54693944893582	YAP1	0.445397004539324
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/209	116/9376	1.16020458670186	PFKP/ACSS1/ME3	0.262146227808581
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/209	73/9376	1.22907517860654	SAMHD1/SERINC3	0.296669649839887
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/209	120/9376	1.12153110047847	PLCG2/IRS1/BCL2	0.202307296332576
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/209	31/9376	1.44713690384319	PFKP	0.376510311640431
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/209	31/9376	1.44713690384319	ACSS1	0.376510311640431
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/209	76/9376	1.18055905313523	LPL/ME3	0.238632590638302
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/209	32/9376	1.40191387559809	PFKP	0.343864022963957
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/209	32/9376	1.40191387559809	ACSS1	0.343864022963957
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/209	32/9376	1.40191387559809	GABARAP	0.343864022963957
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/209	32/9376	1.40191387559809	BCL2	0.343864022963957
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/209	78/9376	1.15028830818305	PFKP/PABPC4L	0.201243977122024
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/209	33/9376	1.3594316369436	SNAP23	0.312302356954042
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/209	125/9376	1.07666985645933	CTSD/GNAI1/BCL2	0.130295819513571
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/209	217/9376	1.03366921703085	CREB3L1/GNAI1/JAG1/AHR/BCL2	0.0757676853559442
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/209	34/9376	1.31944835350408	POLR2L	0.28175092249457
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/209	35/9376	1.28174982911825	PFKP	0.252142562976881
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/209	178/9376	1.00811784312671	WNT2/CCND2/RSPO2/TBL1XR1	0.0165100777570826
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/209	37/9376	1.21246605457132	GLS	0.195517390923295
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/209	37/9376	1.21246605457132	COMT	0.195517390923295
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/209	37/9376	1.21246605457132	UXS1	0.195517390923295
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/209	133/9376	1.0119077598302	PLCG2/IFNAR1/IFNGR2	0.0208830811560337
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/209	38/9376	1.18055905313523	UXS1	0.168395040888508
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/209	38/9376	1.18055905313523	IRS1	0.168395040888508
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/209	138/9376	0.975244435198669	ITPR2/IGF1R/YWHAZ	-0.0442352584556201
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/209	90/9376	0.996916533758639	CFTR/SLC4A2	-0.00443804067897916
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/209	93/9376	0.964757935895457	MMP2/ITPR2	-0.0515707920367543
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/209	191/9376	0.939502492547408	CREB3L1/HDAC9/GNAI1/GNG11	-0.127543917041816
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/209	144/9376	0.934609250398724	IL6ST/WNT2/IGF1R	-0.11939738898098
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/209	193/9376	0.929766715422565	PLCG2/GNAI1/GNG11/CCL4L2	-0.14885879782306
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/209	97/9376	0.924974103487397	GNAI1/GNG11	-0.112148027388899
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/209	98/9376	0.915535592227321	PLCG2/ITPR2	-0.126912605630778
NA	NA	hsa03272	Virion - Hepatitis viruses	1/209	48/9376	0.934609250398724	CD9	-0.0685784762789445
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/209	156/9376	0.862716231137284	IFNAR1/CDK6/YWHAZ	-0.261072541887131
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/209	105/9376	0.854499886078834	PLCG2/ITPR2	-0.226380939493982
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/209	52/9376	0.862716231137284	IGF1R	-0.149887321353357
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/209	110/9376	0.815658982166159	IGF1R/GNAI1	-0.293641437412225
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/209	55/9376	0.815658982166159	PSAP	-0.207022351575072
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	4/209	216/9376	0.830763778132199	CD14/HSPA1A/BCL2/CYBA	-0.379942280940786
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/209	60/9376	0.747687400318979	PLCG2	-0.296036314734439
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/209	119/9376	0.753970487716618	CREB3L1/JAG1	-0.407822065705176
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/209	174/9376	0.77346972446791	CAPN2/HSPA1A/BCL2	-0.45541248079036
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/209	63/9376	0.712083238399028	GPX4	-0.346208389481701
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/209	63/9376	0.712083238399028	POLR2L	-0.346208389481701
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/209	63/9376	0.712083238399028	WNT2	-0.346208389481701
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/209	65/9376	0.690172984909827	LPL	-0.378462595616534
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/209	65/9376	0.690172984909827	ITPR2	-0.378462595616534
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/209	66/9376	0.679715818471799	COMT	-0.394255520100961
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/209	67/9376	0.669570806255802	ITPR2	-0.409835394432678
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/209	69/9376	0.650162956799112	PLCG2	-0.440383103491104
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/209	69/9376	0.650162956799112	CREB3L1	-0.440383103491104
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/209	75/9376	0.598149920255183	PFKP	-0.527563856062506
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/209	75/9376	0.598149920255183	BCL2	-0.527563856062506
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/209	78/9376	0.575144154091523	PLCG2	-0.568904402264139
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/209	79/9376	0.567863848343529	CLTC	-0.582381935982358
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/209	144/9376	0.623072833599149	CD14/C1QA	-0.688233729979794
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/209	86/9376	0.521642372315567	PLCG2	-0.672882506354483
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/209	86/9376	0.521642372315567	CREB3L1	-0.672882506354483
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/209	91/9376	0.492980703507019	PLCG2	-0.73383664679572
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/209	103/9376	0.43554605843824	PABPC4L	-0.869725408862007
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/209	104/9376	0.431358115568642	LPCAT2	-0.880468796014267
NA	NA	hsa04082	Neuroactive ligand signaling	2/209	199/9376	0.450866774061696	GNAI1/GNG11	-1.18222206271835
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/209	128/9376	0.350478468899522	PDE3A	-1.11717135612438
Genetic Information Processing	Translation	hsa03010	Ribosome	2/209	222/9376	0.404155351523773	RPS4Y1/RPS21	-1.35659196950464
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/209	144/9376	0.311536416799575	ITPR2	-1.25707007097861
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/209	154/9376	0.291306779345057	HAAO	-1.33890956891565
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/209	370/9376	0.363739816371395	PTGFR/PRLR/SSTR1	-1.88544905740175
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/209	243/9376	0.184614172918267	HSPA1A	-1.94448560264592
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/209	449/9376	0.0999136837842734	SLC8A1	-2.95120737816181