category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/148	233/9376	7.34114371882612	COL4A1/COL6A1/ITGB1/FBLN1/COL6A2/COL4A2/FBN2/TNNT1/SYNE2/ANK2/MYH10/LMOD1/FBLN2/COL3A1/FBN1/TLN1/LAMA2/COL11A1/FHL1/TNNI3/COL5A1/ACTB/TPM4/COL1A1/SPTBN1/MYH13/THBS1	12.4126325718504
NA	NA	hsa04518	Integrin signaling	22/148	154/9376	9.05019305019305	COL4A1/COL6A1/ITGB1/COL6A2/FLNA/PDGFRA/HGF/COL4A2/PIK3R1/CCND2/LAMB1/VTN/FERMT1/FBN1/TLN1/LAMA2/ACTB/LAMC1/COL1A1/PDGFD/LAMB2/THBS1	12.7560672353131
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/148	203/9376	6.55358807082945	COL4A1/COL6A1/ITGB1/COL6A2/FLNA/PDGFRA/HGF/COL4A2/PIK3R1/CCND2/LAMB1/VTN/TLN1/LAMA2/ACTB/LAMC1/COL1A1/PDGFD/PTEN/LAMB2/THBS1	10.1304488629132
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/148	362/9376	4.20008959235479	COL4A1/COL6A1/ITGB1/COL6A2/PRLR/IGF2/PDGFRA/HGF/COL4A2/PIK3R1/CCND2/LAMB1/FGF10/VTN/LAMA2/YWHAE/LAMC1/COL1A1/CSF1/PDGFD/PTEN/EIF4EBP1/LAMB2/THBS1	7.86358071152064
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/148	103/9376	7.99580162686959	COL4A1/COL6A1/COL6A2/COL4A2/SLC16A10/COL15A1/COL8A2/SLC38A2/COL3A1/COL11A1/MME/COL5A1/COL1A1	9.04083767162898
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/148	89/9376	8.54175523838445	COL4A1/COL6A1/ITGB1/COL6A2/COL4A2/LAMB1/VTN/LAMA2/LAMC1/COL1A1/LAMB2/THBS1	9.0529978481419
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/148	204/9376	4.96873343932167	PLCG2/GPC3/ITGB1/IGF2/FLNA/HGF/PIK3R1/VTN/TGFB2/ANK2/WNT2/MMP2/ACTB/COL1A1/THBS1/ITPR2	7.25767796734507
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	15/148	205/9376	4.63546473302571	MT-ATP8/MT-ND3/PIK3R1/TGFB2/COL3A1/MMP2/MT-CYB/TNNI3/MT-ND4L/CTSD/COL1A1/TGFBR2/CYBA/PTEN/MT-CO2	6.66486294003434
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/148	101/9376	6.27241102488627	PLCG2/COL4A1/COL4A2/PIK3R1/TGFB2/COL3A1/MMP2/COL1A1/TGFBR2/F3	6.74645596816107
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/148	103/9376	6.15061663605353	COL4A1/COL4A2/PIK3R1/LAMB1/TGFB2/COL3A1/LAMA2/LAMC1/COL1A1/LAMB2	6.65626205530195
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/148	88/9376	6.47911547911548	CFD/C7/VTN/PROS1/C1QA/SERPING1/F3/A2M/C1QB	6.53963319311384
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/148	93/9376	6.13077593722755	COL4A1/ITGB1/COL4A2/PIK3R1/LAMB1/LAMA2/LAMC1/PTEN/LAMB2	6.29713568663359
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	17/148	333/9376	3.23415307199091	COL4A1/COL6A1/ITGB1/COL6A2/COL4A2/PIK3R1/CCND2/LAMB1/VTN/WNT2/LAMA2/LAMC1/COL1A1/PTEN/EIF4EBP1/LAMB2/THBS1	5.25704239777504
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/148	170/9376	4.09920508744038	PLCG2/IGF2/HGF/PIK3R1/TGFB2/WNT2/ACTB/TGFBR2/PTEN/GSTT2B/GSTM5	5.16418741120576
Organismal Systems	Immune system	hsa04611	Platelet activation	9/148	126/9376	4.52509652509652	PLCG2/ITGB1/PIK3R1/COL3A1/TLN1/ACTB/COL1A1/PLA2G4A/ITPR2	5.04484843012992
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/148	80/9376	5.54324324324324	PLCG2/PDGFRA/HGF/PIK3R1/PDGFD/PTEN/EIF4EBP1	5.16803716702364
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/148	98/9376	4.52509652509652	PLCG2/PIK3R1/CFL2/ARPC5/ASAP1/PLA2G4A/PLPP3	4.44241953453807
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	11/148	227/9376	3.06988927253244	MT-ATP8/HGF/MT-ND3/PIK3R1/MT-CYB/MT-ND4L/CYBA/PTEN/GSTT2B/MT-CO2/GSTM5	3.99793686525632
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/148	73/9376	5.20696038504258	PDGFRA/HGF/PIK3R1/FGF10/PDGFD/PTEN	4.56963008518831
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	11/148	232/9376	3.00372786579683	ITGB1/PDGFRA/PIK3R1/C7/IQGAP2/FGF10/CFL2/ARPC5/MYH10/ACTB/PDGFD	3.91360801400694
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/148	50/9376	6.33513513513514	HGF/TGFB2/ACKR1/IL18/THBS1	4.79010930721171
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	12/148	275/9376	2.7644226044226	MT-ATP8/MT-ND3/PIK3R1/C7/C1QA/MT-CYB/MT-ND4L/LAMC1/C1QB/CYBA/MT-CO2/ITPR2	3.76085947011868
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/148	212/9376	2.98827129015808	ITGB1/PDGFRA/HGF/PIK3R1/FGF10/TLN1/ACTB/CSF1/PDGFD/THBS1	3.70820499609271
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/148	112/9376	3.95945945945946	ITGB1/LAMB1/TGFB2/LAMA2/LAMC1/HLA-DRA/LAMB2	3.99010970299206
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/148	17/9376	11.1796502384738	MYH10/PCDH7/NRP2	5.31992238745232
NA	NA	hsa04517	IgSF CAM signaling	12/148	299/9376	2.5425291512248	PLCG2/CADM3/ITGB1/NRP1/PIK3R1/NFASC/ANK2/ARPC5/MYH10/ACTB/SPTBN1/NRP2	3.43289491719306
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/148	194/9376	2.93898021733073	DNAH10/TNNT1/MYH10/TNNI3/DYNC1I2/MYO1E/ACTB/TPM4/MYH13	3.45595677447838
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/148	238/9376	2.6618214853509	PLCG2/IGF2/PDGFRA/HGF/PIK3R1/FGF10/RASAL2/PLA2G4A/CSF1/PDGFD	3.28859183526794
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/148	130/9376	3.41122661122661	COL4A1/COL4A2/PIK3R1/COL3A1/MMP2/COL1A1/TGFBR2	3.50586721082166
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/148	99/9376	3.83947583947584	PDGFRA/PIK3R1/PLA2G4A/PDGFD/PLPP3/EIF4EBP1	3.59678683283111
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/148	99/9376	3.83947583947584	ITGB1/TGFB2/LAMA2/TNNI3/ACTB/TPM4	3.59678683283111
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/148	105/9376	3.62007722007722	ITGB1/TGFB2/LAMA2/TNNI3/ACTB/TPM4	3.41907126611629
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	10/148	253/9376	2.50400598226685	PLCG2/ITGB1/PIK3R1/ARPC5/TLN1/IL18/ACTB/TIFA/MAP1LC3C/ITPR2	3.07116881897689
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/148	142/9376	3.12295393985535	PLCG2/PIK3R1/TGFB2/TGFBR2/CSF1/CYBA/ITPR2	3.22814111903633
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/148	142/9376	3.12295393985535	PIK3R1/MMP2/MAP2K5/ACTB/CYBA/GSTT2B/GSTM5	3.22814111903633
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/148	78/9376	4.06098406098406	ITGB1/PIK3R1/ARPC5/ARHGEF26/ACTB	3.43776591707997
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/148	78/9376	4.06098406098406	ITGB1/CFL2/C1QA/SERPING1/C1QB	3.43776591707997
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/148	110/9376	3.45552825552826	FST/TGFB2/FBN1/LTBP1/TGFBR2/THBS1	3.28063439246098
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/148	300/9376	2.32288288288288	IGF2/FLNA/PDGFRA/HGF/FGF10/TGFB2/MAP2K5/TGFBR2/PLA2G4A/CSF1/PDGFD	2.9491542205599
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/148	116/9376	3.27679403541473	PLCG2/ITGB1/PIK3R1/MMP2/ACTB/CYBA	3.12471166900953
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/148	157/9376	2.82458254432777	PIK3R1/CCND2/TGFB2/TGFBR2/PTEN/EIF4EBP1/ITPR2	2.91967248688572
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/148	89/9376	3.55906468266019	PDGFRA/GJA1/MAP2K5/PDGFD/ITPR2	3.07185878261694
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/148	168/9376	2.63963963963964	PRLR/PDGFRA/IL6ST/PIK3R1/CCND2/SOCS2/FHL1	2.71570816307475
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/148	103/9376	3.07530831802676	PIK3R1/TGFB2/C1QA/TGFBR2/C1QB	2.68196936142356
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/148	70/9376	3.62007722007722	HGF/PIK3R1/TGFB2/EPAS1	2.7864053166175
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/148	224/9376	2.26254826254826	NRP1/PIK3R1/CCND2/TGFB2/TLN1/HLA-DRA/TGFBR2/PTEN	2.42201425554422
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/148	71/9376	3.56909021697754	PRLR/PIK3R1/CCND2/SOCS2	2.75177578064332
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/148	41/9376	4.63546473302571	MMP2/DAPK1/THBS1	2.95431912677528
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/148	17/9376	7.45310015898251	PAPSS2/INMT	3.37241370774152
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/148	17/9376	7.45310015898251	GLUL/CA8	3.37241370774152
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/148	149/9376	2.55106112824234	PLCG2/PDGFRA/PIK3R1/PLA2G4A/PDGFD/PLPP3	2.41687667737187
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/148	75/9376	3.37873873873874	CCND2/SESN1/PTEN/THBS1	2.61923977855073
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/148	150/9376	2.53405405405405	HGF/PIK3R1/FGF10/TGFB2/WNT2/TGFBR2	2.39851406803867
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/148	76/9376	3.33428165007112	PLCG2/PDGFRA/PIK3R1/PTEN	2.58750549563582
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/148	78/9376	3.24878724878725	ITGB1/TGFB2/HLA-DRA/CYBA	2.52559438553871
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	8/148	238/9376	2.12945718828072	PLCG2/NRP1/CFD/IL6ST/PIK3R1/C7/C1QA/C1QB	2.23509186781297
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/148	155/9376	2.45231037489102	ITGB1/DYNC1I2/ACTB/HLA-DRA/CYBA/THBS1	2.30886734216495
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/148	157/9376	2.42107075228094	CCND2/TGFB2/WNT2/YWHAE/ACTB/TGFBR2	2.27397833562049
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/148	120/9376	2.63963963963964	PLCG2/PIK3R1/SORT1/YWHAE/MAP2K5	2.28923333974057
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/148	86/9376	2.9465744814582	ITGB1/GJA1/LAMA2/ACTB	2.29654572774104
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/148	87/9376	2.91270580925753	MT-CYB/TNNI3/TPM4/MT-CO2	2.26979181061172
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/148	23/9376	5.50881316098707	MME/ANPEP	2.74165871883901
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/148	133/9376	2.3816297500508	PIK3R1/CCND2/TGFB2/TGFBR2/PTEN	2.03223404720285
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/148	134/9376	2.36385639370714	CALD1/KCNMA1/MYH10/PLA2G4A/ITPR2	2.01372779264561
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/148	95/9376	2.6674253200569	TGFB2/IL18/HLA-DRA/CSF1	2.06858566760398
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/148	59/9376	3.22125515345854	ANPEP/GSTT2B/GSTM5	2.16745010854993
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	6/148	181/9376	2.10004479617739	TGFB2/CD74/IL18/LSP1/CTSD/HLA-DRA	1.89250264233218
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/148	138/9376	2.29533881707795	MT-ATP8/MT-ND3/MT-CYB/MT-ND4L/MT-CO2	1.94131784786812
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/148	138/9376	2.29533881707795	ITGB1/PIK3R1/ARPC5/IL18/ACTB	1.94131784786812
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/148	60/9376	3.16756756756757	PLCG2/PIK3R1/PLA2G4A	2.13302640884183
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/148	98/9376	2.5857694429123	PLCG2/PIK3R1/PTEN/ITPR2	1.99842844027491
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/148	184/9376	2.06580493537015	PLCG2/ITGB1/NRP1/PIK3R1/CFL2/EFNB2	1.84903160121751
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/148	99/9376	2.55965055965056	PLCG2/PIK3R1/PLA2G4A/ITPR2	1.97562188020038
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/148	99/9376	2.55965055965056	CFD/C1QA/HLA-DRA/C1QB	1.97562188020038
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/148	100/9376	2.53405405405405	MME/ANPEP/HLA-DRA/CSF1	1.95309332479956
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/148	187/9376	2.0326636797225	IL18/YWHAE/TXNIP/CYBA/MAP1LC3C/ITPR2	1.80637653462494
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/148	105/9376	2.41338481338481	PLCG2/PIK3R1/LSP1/ITPR2	1.844397320193
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/148	66/9376	2.87960687960688	TGFB2/IL18/HLA-DRA	1.94055902137838
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/148	106/9376	2.39061703212647	PDGFRA/PIK3R1/PDGFD/PTEN	1.82340571985286
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	10/148	388/9376	1.63276678740596	MT-ATP8/MT-ND3/PIK3R1/WNT2/MT-CYB/MME/MT-ND4L/CSF1/MT-CO2/ITPR2	1.61209529246805
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/148	68/9376	2.79491255961844	PIK3R1/ZBTB16/EIF4EBP1	1.88118829782857
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/148	69/9376	2.75440658049354	PLCG2/PIK3R1/PLA2G4A	1.85230559706556
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/148	69/9376	2.75440658049354	KCNMA1/PDE3A/ITPR2	1.85230559706556
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/148	110/9376	2.3036855036855	PLCG2/PIK3R1/EPAS1/EIF4EBP1	1.74174965843486
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/148	200/9376	1.90054054054054	ITGB1/ARPC5/MYH10/MYO1E/IL18/ACTB	1.63025021826962
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	7/148	248/9376	1.78814298169137	FLNA/ARPC5/ARHGEF26/AHNAK/DYNC1I2/IL18/ACTB	1.59296318986075
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/148	70/9376	2.71505791505792	LAMA2/ACTB/HLA-DRA	1.82393345364205
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/148	71/9376	2.67681766273316	PDGFRA/PIK3R1/PTEN	1.7960545730825
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/148	157/9376	2.01755896023412	PROS1/MFGE8/C1QA/C1QB/THBS1	1.62828418435527
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/148	158/9376	2.00478959972631	CDKN1C/CCND2/TGFB2/RAD21/YWHAE	1.61305072879619
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/148	73/9376	2.60348019252129	GSTT2B/MAOA/GSTM5	1.74171151095226
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/148	73/9376	2.60348019252129	PLCG2/HGF/PIK3R1	1.74171151095226
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/148	116/9376	2.18452935694315	GLUL/SLC38A2/PLA2G4A/ITPR2	1.62566865792514
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/148	75/9376	2.53405405405405	PIK3R1/GSTT2B/GSTM5	1.68915372478268
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/148	38/9376	3.33428165007112	NNMT/ENPP1	1.82591611888111
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/148	77/9376	2.46823446823447	PIK3R1/TGFB2/TGFBR2	1.63826954173447
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/148	77/9376	2.46823446823447	PIK3R1/TGFB2/TGFBR2	1.63826954173447
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/148	122/9376	2.07709348692955	PLCG2/PIK3R1/SLC16A10/ACTB	1.516461086563
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/148	122/9376	2.07709348692955	PLCG2/PIK3R1/SOCS2/ITPR2	1.516461086563
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/148	169/9376	1.8743003358388	PIK3R1/CTSD/PTEN/DAPK1/MAP1LC3C	1.45247153136023
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/148	170/9376	1.86327503974563	ITGB1/ARPC5/MYH10/ACTB/AMOTL2	1.43847017763657
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/148	268/9376	1.654699475595	MT-ATP8/MT-ND3/MT-CYB/MT-ND4L/MAOA/MT-CO2/ITPR2	1.37708447472631
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/148	42/9376	3.01673101673102	INMT/MAOA	1.65882826808328
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/148	42/9376	3.01673101673102	SLC40A1/MAP1LC3C	1.65882826808328
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/148	10/9376	6.33513513513514	PAPSS2	2.1376226891942
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/148	86/9376	2.20993086109365	PLCG2/PIK3R1/EIF4EBP1	1.4274622298681
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/148	87/9376	2.18452935694315	PIK3R1/TGFB2/TGFBR2	1.40567097187957
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/148	235/9376	1.61748131109833	MT-ATP8/MT-ND3/MT-CYB/MT-ND4L/ACTB/MT-CO2	1.21401372665006
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/148	47/9376	2.69580218516389	PIK3R1/SOCS2	1.47594194756988
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/148	90/9376	2.11171171171171	PIK3R1/SESN1/EIF4EBP1	1.34202868574339
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/148	137/9376	1.84967449201026	PIK3R1/ACTB/CTSD/ITPR2	1.26871210491548
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/148	139/9376	1.82306047054249	PIK3R1/MMP2/CTSD/ITPR2	1.23804484291423
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/148	93/9376	2.04359197907585	MMP2/PLA2G4A/ITPR2	1.2808277683773
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/148	93/9376	2.04359197907585	CST3/KCNMA1/ITPR2	1.2808277683773
NA	NA	hsa04519	Cadherin signaling	9/148	404/9376	1.41129248059941	PDGFRA/GJA1/ARPC5/WNT2/MYO1E/PCDH7/YWHAE/ACTB/AMOTL2	1.07018663432689
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/148	143/9376	1.77206577206577	C7/C1QA/HLA-DRA/C1QB	1.17818530933105
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/148	298/9376	1.4881189914747	PRLR/IL1RL1/IL6ST/TGFB2/IL18/TGFBR2/CSF1	1.08442981912611
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/148	51/9376	2.48436671966084	PLA2G4A/PLPP3	1.34606049790794
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/148	51/9376	2.48436671966084	PLCG2/ACTB	1.34606049790794
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/148	196/9376	1.61610590182019	PLCG2/IL6ST/PIK3R1/MAP1LC3C/ITPR2	1.10388737668282
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/148	52/9376	2.43659043659044	PLTP/SORT1	1.31551623867318
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/148	250/9376	1.52043243243243	PDGFRA/DAB2/ARPC5/ASAP1/TGFBR2/RAB11FIP1	1.05622593783152
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/148	148/9376	1.71219868517166	PIK3R1/FGF10/WNT2/PTEN	1.10596385927443
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/148	100/9376	1.90054054054054	IL6ST/IL18/CSF1	1.14653047185203
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/148	254/9376	1.49648861459885	PLCG2/PDGFRA/HGF/FGF10/PDGFD/ITPR2	1.01588330009367
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/148	56/9376	2.26254826254826	CCND2/SCUBE2	1.20004283666783
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/148	16/9376	3.95945945945946	MAOA	1.50036583091767
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	8/148	368/9376	1.37720329024677	MT-ATP8/DNAH10/MT-ND3/MT-CYB/MT-ND4L/ACTB/MT-CO2/MAP1LC3C	0.93486283695919
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/148	154/9376	1.64548964548965	MAP2K5/ACTB/PLA2G4A/ITPR2	1.02282134928017
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	10/148	480/9376	1.31981981981982	MT-ATP8/DNAH10/MT-ND3/WNT2/MT-CYB/MT-ND4L/CSF1/MT-CO2/MAP1LC3C/ITPR2	0.910943222101564
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/148	59/9376	2.14750343563903	PIK3R1/PTEN	1.1197076762049
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/148	158/9376	1.60383167978105	PIK3R1/WNT2/PTEN/EIF4EBP1	0.969368245258861
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/148	60/9376	2.11171171171171	PLA2G4A/ITPR2	1.09399608832536
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/148	160/9376	1.58378378378378	CADM3/ITGB1/NFASC/HLA-DRA	0.943199340334158
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/148	109/9376	1.74361517480784	IL6ST/HLA-DRA/TGFBR2	0.988905094388433
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/148	323/9376	1.37293950297046	PLCG2/PDGFRA/PIK3R1/CCND2/TGFB2/PTEN/THBS1	0.863785862355826
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/148	214/9376	1.48017176054559	PLCG2/SAMHD1/PIK3R1/CFL2/ITPR2	0.899851947762839
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/148	217/9376	1.45970855648275	PIK3R1/FGF10/GSTT2B/EIF4EBP1/GSTM5	0.867663099023262
NA	NA	hsa04081	Hormone signaling	5/148	219/9376	1.44637788473405	PRLR/IGF2/PIK3R1/SLC16A10/SLC40A1	0.846468542874686
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/148	115/9376	1.65264394829612	PLA2G4A/MAOA/ITPR2	0.891782604129493
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/148	65/9376	1.94927234927235	PIK3R1/ITPR2	0.972550247589345
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/148	21/9376	3.01673101673102	ENPP1	1.17165144395202
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/148	227/9376	1.39540421478747	PDGFRA/PIK3R1/AKAP13/EIF4EBP1/ITPR2	0.763712874864322
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/148	173/9376	1.46477112951101	PIK3R1/IL18/ACTB/HLA-DRA	0.781376213516862
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/148	22/9376	2.87960687960688	MAOA	1.11774410102597
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/148	70/9376	1.81003861003861	GSTT2B/GSTM5	0.861461590666594
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/148	23/9376	2.75440658049354	GLUL	1.06679605609243
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/148	178/9376	1.42362587306408	SERPINF1/CCND2/WNT2/SFRP2	0.722617505846193
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/148	125/9376	1.52043243243243	PIK3R1/CTSD/PTEN	0.741801525649186
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/148	180/9376	1.40780780780781	PIK3R1/CD74/HLA-DRA/EIF4EBP1	0.69960839254985
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/148	128/9376	1.4847972972973	ENPP1/PAPSS2/PDE3A	0.699365117865982
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/148	76/9376	1.66714082503556	ACTB/ITPR2	0.739512539581476
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/148	26/9376	2.43659043659044	PLA2G4A	0.928916212023692
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/148	26/9376	2.43659043659044	SLC19A3	0.928916212023692
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/148	78/9376	1.62439362439362	PLCG2/PTEN	0.701251322456203
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/148	79/9376	1.60383167978105	GSTT2B/GSTM5	0.682528400671218
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	6/148	308/9376	1.23411723411723	MT-ATP8/DNAH10/MT-ND3/MT-CYB/MT-ND4L/MT-CO2	0.529073111195545
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/148	195/9376	1.2995148995149	PLCG2/PIK3R1/ACTB/CYBA	0.535246019722284
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/148	138/9376	1.37720329024677	PIK3R1/SOCS2/EIF4EBP1	0.56531269655186
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/148	82/9376	1.54515491100857	GSTT2B/GSTM5	0.627896733673599
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/148	82/9376	1.54515491100857	CD74/HLA-DRA	0.627896733673599
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/148	83/9376	1.52653858677955	SAMHD1/IL18	0.61017440179878
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/148	30/9376	2.11171171171171	PLA2G4A	0.772329498887232
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/148	31/9376	2.04359197907585	GLUL	0.737029090092098
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/148	144/9376	1.31981981981982	IL6ST/PIK3R1/WNT2	0.489780426857392
Human Diseases	Immune disease	hsa05310	Asthma	1/148	32/9376	1.97972972972973	HLA-DRA	0.703035999687594
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/148	205/9376	1.23612392880686	PLCG2/PIK3R1/CCND2/HLA-DRA	0.43288375432825
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/148	205/9376	1.23612392880686	IL6ST/PIK3R1/CCND2/YWHAE	0.43288375432825
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/148	89/9376	1.42362587306408	GLUL/SLC38A2	0.508513468820534
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/148	90/9376	1.40780780780781	PIK3R1/PTEN	0.492294693473669
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/148	149/9376	1.27553056412117	MT-ND3/MT-ND4L/ITPR2	0.429334074719666
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/148	91/9376	1.39233739233739	PLCG2/PIK3R1	0.476268815543291
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/148	93/9376	1.36239465271723	ACTB/TGFBR2	0.444776448667917
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/148	36/9376	1.75975975975976	ENPP1	0.578384709131443
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/148	36/9376	1.75975975975976	GALNT15	0.578384709131443
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/148	37/9376	1.71219868517166	GLUL	0.549685833999454
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/148	37/9376	1.71219868517166	MAOA	0.549685833999454
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/148	37/9376	1.71219868517166	IL18	0.549685833999454
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/148	157/9376	1.21053537614047	PIK3R1/MT-CYB/MT-CO2	0.336895881824817
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/148	38/9376	1.66714082503556	PIK3R1	0.521849274683268
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/148	39/9376	1.62439362439362	HLA-DRA	0.494822896299136
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/148	99/9376	1.27982527982528	PIK3R1/MMP2	0.354456927569646
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/148	163/9376	1.16597579174266	PIK3R1/TGFB2/TGFBR2	0.270707768316157
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/148	41/9376	1.54515491100857	MAOA	0.443013947025052
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/148	102/9376	1.24218335983042	KCNMA1/ITPR2	0.311439392077987
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/148	166/9376	1.14490394008466	KCNMA1/PDE3A/ITPR2	0.238543246972562
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/148	104/9376	1.21829521829522	PLA2G4A/PLPP3	0.283489438569094
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/148	43/9376	1.4732872407291	PLPP3	0.393922778393187
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/148	44/9376	1.43980343980344	HLA-DRA	0.370305615458313
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/148	44/9376	1.43980343980344	DYNC1I2	0.370305615458313
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/148	45/9376	1.40780780780781	ABCA8	0.347264510288351
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/148	45/9376	1.40780780780781	HLA-DRA	0.347264510288351
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/148	109/9376	1.16241011653856	PIK3R1/PTEN	0.215982939921448
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/148	48/9376	1.31981981981982	PIK3R1	0.281315995867227
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/148	49/9376	1.29288472145615	GALNT15	0.260307374355334
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/148	49/9376	1.29288472145615	MAOA	0.260307374355334
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/148	115/9376	1.10176263219741	PIK3R1/ITPR2	0.139050006333479
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/148	115/9376	1.10176263219741	AKAP13/ITPR2	0.139050006333479
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/148	50/9376	1.26702702702703	MAOA	0.239748125406543
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/148	50/9376	1.26702702702703	HLA-DRA	0.239748125406543
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/148	117/9376	1.08292908292908	ACTB/BCL7A	0.114309007658638
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/148	119/9376	1.06472859414036	PIK3R1/CSF1	0.0899906163549483
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/148	52/9376	1.21829521829522	PLA2G4A	0.199897547121105
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/148	122/9376	1.03854674346478	PIK3R1/EIF4EBP1	0.0542707176186677
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/148	54/9376	1.17317317317317	HLA-DRA	0.161616481812741
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/148	55/9376	1.15184275184275	PLPP3	0.143023321481149
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/148	56/9376	1.13127413127413	IL18	0.124775096167297
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/148	59/9376	1.07375171781951	ENPP1	0.0719652438598759
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/148	59/9376	1.07375171781951	PIK3R1	0.0719652438598759
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/148	201/9376	0.945542557482856	CCND2/ZBTB16/TGFBR2	-0.0988359490749754
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/148	61/9376	1.03854674346478	SLC40A1	0.0382493345999899
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/148	133/9376	0.952651900020321	PLCG2/PIK3R1	-0.0696441436973474
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/148	133/9376	0.952651900020321	MAOA/ITPR2	-0.0696441436973474
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/148	62/9376	1.02179598953792	PIK3R1	0.0218055488132918
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/148	63/9376	1.00557700557701	NSD1	0.00562456907910825
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/148	63/9376	1.00557700557701	PLA2G4A	0.00562456907910825
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/148	63/9376	1.00557700557701	WNT2	0.00562456907910825
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/148	136/9376	0.931637519872814	PIK3R1/CCND2	-0.10169836753746
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/148	138/9376	0.918135526831179	YWHAE/ITPR2	-0.122689879106271
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/148	65/9376	0.974636174636175	PLPP3	-0.0259857928615638
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/148	65/9376	0.974636174636175	ITPR2	-0.0259857928615638
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/148	140/9376	0.905019305019305	MAP1LC3C/ITPR2	-0.143390408406269
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/148	67/9376	0.945542557482856	ITPR2	-0.0566507717880401
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/148	216/9376	0.87987987987988	PIK3R1/IL18/CYBA	-0.226181770619737
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/148	144/9376	0.87987987987988	C1QA/C1QB	-0.18395508989949
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/148	144/9376	0.87987987987988	PIK3R1/ITPR2	-0.18395508989949
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/148	69/9376	0.918135526831179	MAOA	-0.0864326567954237
NA	NA	hsa04382	Cornified envelope formation	3/148	217/9376	0.87582513388965	COL4A1/COL4A2/S100A8	-0.234370119134704
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/148	71/9376	0.892272554244385	PLCG2	-0.115387842039126
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/148	73/9376	0.867826730840429	SAMHD1	-0.143567538538434
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/148	226/9376	0.840947141832098	PIK3R1/TNNI3/PDE3A	-0.306512262102993
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/148	75/9376	0.844684684684685	GLUL	-0.171018382753426
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/148	75/9376	0.844684684684685	ITPR2	-0.171018382753426
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/148	76/9376	0.833570412517781	PLTP	-0.184483938445699
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/148	154/9376	0.822744822744823	TNNI3/TPM4	-0.280872638056817
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/148	155/9376	0.81743679163034	WNT2/ITPR2	-0.290237016117985
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/148	156/9376	0.812196812196812	PIK3R1/YWHAE	-0.299545294274816
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/148	79/9376	0.801915839890523	SLC6A2	-0.223900251551635
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/148	85/9376	0.745310015898251	ENPP1	-0.298712091104837
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/148	86/9376	0.736643620364551	KCNMA1	-0.310704765877783
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/148	168/9376	0.754182754182754	GLUL/PLA2G4A	-0.407143060555163
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/148	91/9376	0.696168696168696	PDE3A	-0.368828916200444
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/148	93/9376	0.681197326358617	HLA-DRA	-0.391274871041464
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/148	94/9376	0.673950546290972	S100A8	-0.402336399050649
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/148	98/9376	0.646442360728075	ITPR2	-0.44556265398825
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/148	101/9376	0.627241102488627	WNT2	-0.476973717893132
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/148	193/9376	0.65649068757877	PLCG2/PIK3R1	-0.610643277619927
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/148	105/9376	0.603346203346203	PLCG2	-0.517613598691934
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/148	105/9376	0.603346203346203	MAP1LC3C	-0.517613598691934
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/148	107/9376	0.592068704218237	ITPR2	-0.53743404660391
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/148	109/9376	0.581205058269278	PIK3R1	-0.556939214545536
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/148	110/9376	0.575921375921376	PIK3R1	-0.566577442604328
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/148	370/9376	0.684879474068663	PRLR/NR3C1/LYPD6/SPX	-0.783202899000868
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/148	122/9376	0.519273371732388	PIK3R1	-0.6768244668535
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/148	250/9376	0.506810810810811	SORT1/CTSD	-1.00093534033805
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/148	191/9376	0.331682467808122	MAOA	-1.18174197165182
NA	NA	hsa04082	Neuroactive ligand signaling	1/148	199/9376	0.318348499253022	SLC6A2	-1.23083906181511
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/148	243/9376	0.260705149594039	SF3B5	-1.47868882940781