ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 29/227 168/18639 0.172619047619048 14.17377281309 3.36975949805036e-25 2.14653680025808e-22 GO:0005178 integrin binding 18/227 161/18639 0.111801242236025 9.18001477549457 1.16692855280326e-12 3.7166674406784e-10 GO:0005539 glycosaminoglycan binding 21/227 242/18639 0.0867768595041322 7.12525940219172 2.13655556222409e-12 4.53661964378915e-10 GO:0008201 heparin binding 18/227 172/18639 0.104651162790698 8.59292080729434 3.6381956765299e-12 5.79382661487386e-10 GO:0003779 actin binding 27/227 443/18639 0.0609480812641084 5.00445500740844 6.14435127159829e-12 7.82790352001622e-10 GO:1901681 sulfur compound binding 21/227 275/18639 0.0763636363636364 6.27022827392871 2.45596629223022e-11 2.60741754691775e-09 GO:0030020 extracellular matrix structural constituent conferring tensile strength 10/227 44/18639 0.227272727272727 18.6613936724069 1.0170492721887e-10 9.05565300478146e-09 GO:0019838 growth factor binding 15/227 136/18639 0.110294117647059 9.05626457631511 1.13728766151101e-10 9.05565300478146e-09 GO:0048407 platelet-derived growth factor binding 6/227 11/18639 0.545454545454545 44.7873448137765 1.34121128374868e-09 9.49279541942119e-08 GO:0051015 actin filament binding 16/227 209/18639 0.076555023923445 6.28594313175811 6.08037056219625e-09 3.87319604811901e-07 GO:0097493 structural molecule activity conferring elasticity 5/227 11/18639 0.454545454545455 37.3227873448138 1.11595803145749e-07 6.18420887222599e-06 GO:0050840 extracellular matrix binding 9/227 67/18639 0.134328358208955 11.0297192451838 1.16500010151824e-07 6.18420887222599e-06 GO:0019955 cytokine binding 12/227 144/18639 0.0833333333333333 6.84251101321586 2.00655967581084e-07 9.83214241147313e-06 GO:0005518 collagen binding 9/227 72/18639 0.125 10.2637665198238 2.19992228831519e-07 1.00096464118341e-05 GO:0001968 fibronectin binding 6/227 30/18639 0.2 16.4220264317181 1.4202409852759e-06 6.03129005080498e-05 GO:0016918 retinal binding 4/227 19/18639 0.210526315789474 17.2863436123348 7.19270323965851e-05 0.00286359497728904 GO:0061134 peptidase regulator activity 11/227 226/18639 0.0486725663716814 3.99651085727652 0.000106827572948453 0.00400289199812734 GO:0008083 growth factor activity 9/227 162/18639 0.0555555555555556 4.56167400881057 0.000169582008121155 0.0060013188429542 GO:0002020 protease binding 8/227 136/18639 0.0588235294117647 4.83000777403472 0.000264637663650621 0.00871589993590699 GO:0140031 phosphorylation-dependent protein binding 3/227 11/18639 0.272727272727273 22.3936724068883 0.000273654629070863 0.00871589993590699 GO:0019199 transmembrane receptor protein kinase activity 6/227 78/18639 0.0769230769230769 6.31616401219926 0.000377772605626836 0.0114591023706807 GO:0008237 metallopeptidase activity 9/227 184/18639 0.0489130434782609 4.01625646427887 0.00043566562802214 0.0126145002295501 GO:0005523 tropomyosin binding 3/227 15/18639 0.2 16.4220264317181 0.000727921251121496 0.0199533613860797 GO:0001786 phosphatidylserine binding 5/227 59/18639 0.0847457627118644 6.95848577615172 0.000751774997277727 0.0199533613860797 GO:0045296 cadherin binding 12/227 334/18639 0.0359281437125748 2.95006462845235 0.000844442420058594 0.0209474389692328 GO:0005159 insulin-like growth factor receptor binding 3/227 16/18639 0.1875 15.3956497797357 0.00088788202852321 0.0209474389692328 GO:0019841 retinol binding 3/227 16/18639 0.1875 15.3956497797357 0.00088788202852321 0.0209474389692328 GO:0033218 amide binding 10/227 247/18639 0.0404858299595142 3.32429684852592 0.000928940658337887 0.0211333999771869 GO:0005516 calmodulin binding 9/227 207/18639 0.0434782608695652 3.57000574602567 0.00101172677173021 0.0219191343900735 GO:0043394 proteoglycan binding 4/227 37/18639 0.108108108108108 8.87677104417193 0.0010322983229234 0.0219191343900735 GO:0005501 retinoid binding 4/227 38/18639 0.105263157894737 8.6431718061674 0.00114283592443575 0.0227495776207992 GO:0019840 isoprenoid binding 4/227 38/18639 0.105263157894737 8.6431718061674 0.00114283592443575 0.0227495776207992 GO:0097110 scaffold protein binding 5/227 70/18639 0.0714285714285714 5.86500943989931 0.00163126888136487 0.0314884326493765 GO:0004857 enzyme inhibitor activity 13/227 416/18639 0.03125 2.56594162995595 0.00183620811380595 0.0344018990733645 GO:0004222 metalloendopeptidase activity 6/227 110/18639 0.0545454545454545 4.47873448137765 0.00228391538357268 0.0415444865268117 GO:0098631 cell adhesion mediator activity 5/227 76/18639 0.0657894736842105 5.40198237885463 0.00234788306901919 0.0415444865268117 GO:0005200 structural constituent of cytoskeleton 6/227 112/18639 0.0535714285714286 4.39875707992448 0.00250051601074674 0.0425054456592495 GO:0005504 fatty acid binding 4/227 47/18639 0.0851063829787234 6.98809635392258 0.00253564667982964 0.0425054456592495 GO:0005158 insulin receptor binding 3/227 23/18639 0.130434782608696 10.710017238077 0.00263699857129099 0.0430709766644195 GO:0009055 electron transfer activity 6/227 116/18639 0.0517241379310345 4.2470758013064 0.00297962382012054 0.0464055718262035 GO:0050431 transforming growth factor beta binding 3/227 24/18639 0.125 10.2637665198238 0.00298685784124701 0.0464055718262035 GO:0005543 phospholipid binding 14/227 497/18639 0.028169014084507 2.31296146925607 0.00320850655007101 0.0486623493427437 GO:0030247 polysaccharide binding 3/227 26/18639 0.115384615384615 9.47424601829888 0.00376885840286976 0.0558316930843729 GO:0023026 MHC class II protein complex binding 3/227 27/18639 0.111111111111111 9.12334801762115 0.00420225179390503 0.0608371452890341 GO:0098632 cell-cell adhesion mediator activity 4/227 55/18639 0.0727272727272727 5.9716459751702 0.00449546516250627 0.0636358068559221 GO:0030414 peptidase inhibitor activity 7/227 169/18639 0.0414201183431953 3.40101139118421 0.00472829536666874 0.065476611925391 GO:0072341 modified amino acid binding 5/227 91/18639 0.0549450549450549 4.51154572299947 0.00510444937004186 0.0678057036031273 GO:0016504 peptidase activator activity 4/227 57/18639 0.0701754385964912 5.76211453744493 0.00510937797951352 0.0678057036031273 GO:0043178 alcohol binding 5/227 92/18639 0.0543478260869565 4.46250718253208 0.00534545910353957 0.0694909683460145 GO:0042562 hormone binding 5/227 94/18639 0.0531914893617021 4.36756022120161 0.00585143152000064 0.0745472375648081 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/227 60/18639 0.0666666666666667 5.47400881057269 0.00613171900331772 0.0763274832380323 GO:0043121 neurotrophin binding 2/227 10/18639 0.2 16.4220264317181 0.00623081495820671 0.0763274832380323 GO:0004896 cytokine receptor activity 5/227 96/18639 0.0520833333333333 4.27656938325991 0.00639024197948213 0.076803474357172 GO:0070851 growth factor receptor binding 6/227 139/18639 0.0431654676258993 3.54432225144994 0.00716882054929845 0.0829706597983106 GO:0019956 chemokine binding 3/227 33/18639 0.0909090909090909 7.46455746896276 0.00743016490956237 0.0829706597983106 GO:0061135 endopeptidase regulator activity 7/227 184/18639 0.0380434782608696 3.12375502777246 0.00744385914049953 0.0829706597983106 GO:0048185 activin binding 2/227 11/18639 0.181818181818182 14.9291149379255 0.00755462836468134 0.0829706597983106 GO:0050998 nitric-oxide synthase binding 2/227 11/18639 0.181818181818182 14.9291149379255 0.00755462836468134 0.0829706597983106 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/227 68/18639 0.0588235294117647 4.83000777403472 0.00949874954394659 0.102554295923627 GO:0023023 MHC protein complex binding 3/227 37/18639 0.0810810810810811 6.65757828312894 0.0102118539628021 0.108327661483493 GO:0017154 semaphorin receptor activity 2/227 13/18639 0.153846153846154 12.6323280243985 0.0105436656388957 0.108327661483493 GO:0019855 calcium channel inhibitor activity 2/227 13/18639 0.153846153846154 12.6323280243985 0.0105436656388957 0.108327661483493 GO:0000146 microfilament motor activity 3/227 38/18639 0.0789473684210526 6.48237885462555 0.0109891983660907 0.111113005701583 GO:0005161 platelet-derived growth factor receptor binding 2/227 14/18639 0.142857142857143 11.7300188797986 0.0122030097661686 0.120030073322539 GO:0140375 immune receptor activity 6/227 156/18639 0.0384615384615385 3.15808200609963 0.0122479666655652 0.120030073322539 GO:0004866 endopeptidase inhibitor activity 6/227 161/18639 0.0372670807453416 3.06000492516486 0.0141288179681905 0.135210197198477 GO:0008307 structural constituent of muscle 3/227 42/18639 0.0714285714285714 5.86500943989931 0.0144337416161639 0.135210197198477 GO:0042056 chemoattractant activity 3/227 42/18639 0.0714285714285714 5.86500943989931 0.0144337416161639 0.135210197198477 GO:0033293 monocarboxylic acid binding 4/227 79/18639 0.0506329113924051 4.15747504600457 0.0158103231751982 0.142087376885358 GO:0046332 SMAD binding 4/227 79/18639 0.0506329113924051 4.15747504600457 0.0158103231751982 0.142087376885358 GO:0005024 transforming growth factor beta receptor activity 2/227 16/18639 0.125 10.2637665198238 0.0158370545664998 0.142087376885358 GO:0030547 signaling receptor inhibitor activity 3/227 44/18639 0.0681818181818182 5.59841810172207 0.0163596709893749 0.144737644725442 GO:0001618 virus receptor activity 4/227 81/18639 0.0493827160493827 4.05482134116495 0.0171832572846366 0.146156897508341 GO:0015101 organic cation transmembrane transporter activity 4/227 81/18639 0.0493827160493827 4.05482134116495 0.0171832572846366 0.146156897508341 GO:0008429 phosphatidylethanolamine binding 2/227 17/18639 0.117647058823529 9.66001554806945 0.0178061957815114 0.146156897508341 GO:0030169 low-density lipoprotein particle binding 2/227 17/18639 0.117647058823529 9.66001554806945 0.0178061957815114 0.146156897508341 GO:0046965 nuclear retinoid X receptor binding 2/227 17/18639 0.117647058823529 9.66001554806945 0.0178061957815114 0.146156897508341 GO:0140272 exogenous protein binding 4/227 82/18639 0.0487804878048781 4.00537230041904 0.0178967629602051 0.146156897508341 GO:0001540 amyloid-beta binding 4/227 83/18639 0.0481927710843374 3.95711480282363 0.0186284639666706 0.150206728440116 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/227 18/18639 0.111111111111111 9.12334801762115 0.0198731291998258 0.156286213583815 GO:1901611 phosphatidylglycerol binding 2/227 18/18639 0.111111111111111 9.12334801762115 0.0198731291998258 0.156286213583815 GO:0097001 ceramide binding 2/227 19/18639 0.105263157894737 8.6431718061674 0.022035202788278 0.171175904586989 GO:0005021 vascular endothelial growth factor receptor activity 3/227 51/18639 0.0588235294117647 4.83000777403472 0.0241842038814867 0.185606480391651 GO:0044325 transmembrane transporter binding 5/227 136/18639 0.0367647058823529 3.0187548587717 0.0255596060940987 0.193827012880248 GO:0017046 peptide hormone binding 3/227 53/18639 0.0566037735849057 4.64774332973153 0.0267305282499497 0.199184968793235 GO:0004175 endopeptidase activity 10/227 405/18639 0.0246913580246914 2.02741067058248 0.0270987824181829 0.199184968793235 GO:0031406 carboxylic acid binding 6/227 187/18639 0.0320855614973262 2.63454969492803 0.0272042265070823 0.199184968793235 GO:0043177 organic acid binding 6/227 189/18639 0.0317460317460317 2.60667086217747 0.0284579453781917 0.203943013808266 GO:0004713 protein tyrosine kinase activity 5/227 140/18639 0.0357142857142857 2.93250471994965 0.0284943928240749 0.203943013808266 GO:0008093 cytoskeletal anchor activity 2/227 22/18639 0.0909090909090909 7.46455746896276 0.0290664833170932 0.205726109699871 GO:0042277 peptide binding 7/227 249/18639 0.0281124497991968 2.30831696831378 0.0332107905489825 0.232475533842877 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/227 24/18639 0.0833333333333333 6.84251101321586 0.0341832788534223 0.234137082039032 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/227 24/18639 0.0833333333333333 6.84251101321586 0.0341832788534223 0.234137082039032 GO:0019209 kinase activator activity 5/227 148/18639 0.0337837837837838 2.77399095130373 0.0349836206069317 0.235980753196863 GO:0045309 protein phosphorylated amino acid binding 3/227 59/18639 0.0508474576271186 4.17509146569103 0.0351933619367379 0.235980753196863 GO:0008238 exopeptidase activity 4/227 102/18639 0.0392156862745098 3.22000518268982 0.0361157845498722 0.239610944614374 GO:0003707 nuclear steroid receptor activity 2/227 25/18639 0.08 6.56881057268722 0.0368632222483652 0.239610944614374 GO:0042974 nuclear retinoic acid receptor binding 2/227 25/18639 0.08 6.56881057268722 0.0368632222483652 0.239610944614374 GO:0015026 coreceptor activity 3/227 61/18639 0.0491803278688525 4.03820322091428 0.0382861484609363 0.246346227975924 GO:0003774 cytoskeletal motor activity 5/227 153/18639 0.0326797385620915 2.68333765224151 0.0394678038432194 0.247437565879154 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/227 26/18639 0.0769230769230769 6.31616401219926 0.0396210859021565 0.247437565879154 GO:0005160 transforming growth factor beta receptor binding 2/227 26/18639 0.0769230769230769 6.31616401219926 0.0396210859021565 0.247437565879154 GO:0004364 glutathione transferase activity 2/227 27/18639 0.0740740740740741 6.08223201174743 0.0424545926308166 0.257557861960287 GO:0005044 scavenger receptor activity 2/227 27/18639 0.0740740740740741 6.08223201174743 0.0424545926308166 0.257557861960287 GO:0005104 fibroblast growth factor receptor binding 2/227 27/18639 0.0740740740740741 6.08223201174743 0.0424545926308166 0.257557861960287 GO:0038024 cargo receptor activity 3/227 65/18639 0.0461538461538462 3.78969840731955 0.0448722917168077 0.267548898695364 GO:0046625 sphingolipid binding 2/227 28/18639 0.0714285714285714 5.86500943989931 0.0453615087270006 0.267548898695364 GO:0046966 nuclear thyroid hormone receptor binding 2/227 28/18639 0.0714285714285714 5.86500943989931 0.0453615087270006 0.267548898695364 GO:0008235 metalloexopeptidase activity 3/227 66/18639 0.0454545454545455 3.73227873448138 0.0466011839836009 0.272339029335356 GO:0043236 laminin binding 2/227 29/18639 0.0689655172413793 5.66276773507519 0.0483396432464988 0.278943410390018 GO:0005096 GTPase activator activity 7/227 271/18639 0.025830258302583 2.12092592291562 0.0486070934902543 0.278943410390018 GO:0048019 receptor antagonist activity 2/227 30/18639 0.0666666666666667 5.47400881057269 0.0513868473055459 0.291257937002962 GO:0005126 cytokine receptor binding 7/227 275/18639 0.0254545454545455 2.09007609130957 0.0518231098044006 0.291257937002962 GO:0017124 SH3 domain binding 4/227 115/18639 0.0347826086956522 2.85600459682053 0.052124654345899 0.291257937002962 GO:0015399 primary active transmembrane transporter activity 5/227 166/18639 0.0301204819277108 2.47319675176477 0.0527014553018779 0.291920235019967 GO:1990782 protein tyrosine kinase binding 4/227 117/18639 0.0341880341880342 2.80718400542189 0.0548807775395676 0.301371166316418 GO:0022853 active monoatomic ion transmembrane transporter activity 4/227 118/18639 0.0338983050847458 2.78339431046069 0.0562879197617664 0.306185063027799 GO:0031369 translation initiation factor binding 2/227 32/18639 0.0625 5.13188325991189 0.0576800746677172 0.306185063027799 GO:0071813 lipoprotein particle binding 2/227 32/18639 0.0625 5.13188325991189 0.0576800746677172 0.306185063027799 GO:0071814 protein-lipid complex binding 2/227 32/18639 0.0625 5.13188325991189 0.0576800746677172 0.306185063027799 GO:0035091 phosphatidylinositol binding 7/227 284/18639 0.0246478873239437 2.02384128559906 0.0595406874919809 0.313449734978445 GO:0030296 protein tyrosine kinase activator activity 2/227 33/18639 0.0606060606060606 4.97637164597517 0.0609220043295336 0.318092760310762 GO:0019207 kinase regulator activity 7/227 287/18639 0.024390243902439 2.00268615020952 0.0622625393028303 0.322449085657747 GO:0004252 serine-type endopeptidase activity 5/227 176/18639 0.0284090909090909 2.33267420905086 0.0644430431112787 0.331050148886166 GO:0035591 signaling adaptor activity 4/227 129/18639 0.0310077519379845 2.54605060956869 0.0730284423000328 0.372152941960967 GO:0048306 calcium-dependent protein binding 3/227 80/18639 0.0375 3.07912995594714 0.0741065701991844 0.374649882673655 GO:0015078 proton transmembrane transporter activity 5/227 185/18639 0.027027027027027 2.21919276104298 0.0761664481867077 0.382031712558526 GO:0030695 GTPase regulator activity 10/227 489/18639 0.0204498977505112 1.67914380692414 0.0769194573333003 0.382141008941178 GO:0060589 nucleoside-triphosphatase regulator activity 10/227 490/18639 0.0204081632653061 1.67571698282837 0.0777266160236562 0.382141008941178 GO:0005179 hormone activity 4/227 132/18639 0.0303030303030303 2.48818582298759 0.0779879610084038 0.382141008941178 GO:0030331 nuclear estrogen receptor binding 2/227 40/18639 0.05 4.10550660792952 0.0852136769162208 0.414359635081165 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/227 41/18639 0.0487804878048781 4.00537230041904 0.0888901767108309 0.422919762984704 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/227 41/18639 0.0487804878048781 4.00537230041904 0.0888901767108309 0.422919762984704 GO:0008236 serine-type peptidase activity 5/227 194/18639 0.0257731958762887 2.1162405195513 0.0889658528099691 0.422919762984704 GO:0008081 phosphoric diester hydrolase activity 3/227 87/18639 0.0344827586206897 2.8313838675376 0.0900154048854851 0.424739354904104 GO:0051020 GTPase binding 7/227 315/18639 0.0222222222222222 1.82466960352423 0.0912917233847031 0.427496232047568 GO:0016651 oxidoreductase activity, acting on NAD(P)H 3/227 88/18639 0.0340909090909091 2.79920905086103 0.0923960454871812 0.427496232047568 GO:0048487 beta-tubulin binding 2/227 42/18639 0.0476190476190476 3.91000629326621 0.0926129984655642 0.427496232047568 GO:0017171 serine hydrolase activity 5/227 198/18639 0.0252525252525253 2.07348818582299 0.0949923416254594 0.435324615938256 GO:0008200 ion channel inhibitor activity 2/227 43/18639 0.0465116279069767 3.81907591435304 0.096380480781325 0.437834528769577 GO:0001223 transcription coactivator binding 2/227 44/18639 0.0454545454545455 3.73227873448138 0.100190995533323 0.437834528769577 GO:0003954 NADH dehydrogenase activity 2/227 44/18639 0.0454545454545455 3.73227873448138 0.100190995533323 0.437834528769577 GO:0016248 channel inhibitor activity 2/227 44/18639 0.0454545454545455 3.73227873448138 0.100190995533323 0.437834528769577 GO:0043014 alpha-tubulin binding 2/227 44/18639 0.0454545454545455 3.73227873448138 0.100190995533323 0.437834528769577 GO:0141110 transporter inhibitor activity 2/227 45/18639 0.0444444444444444 3.64933920704846 0.104042947312989 0.437834528769577 GO:0051219 phosphoprotein binding 3/227 93/18639 0.032258064516129 2.64871394059969 0.104681363146537 0.437834528769577 GO:0004180 carboxypeptidase activity 2/227 46/18639 0.0434782608695652 3.57000574602567 0.107934772878459 0.437834528769577 GO:0004867 serine-type endopeptidase inhibitor activity 3/227 95/18639 0.0315789473684211 2.59295154185022 0.10976708810191 0.437834528769577 GO:0019842 vitamin binding 4/227 150/18639 0.0266666666666667 2.18960352422907 0.111091474782753 0.437834528769577 GO:0001784 phosphotyrosine residue binding 2/227 47/18639 0.0425531914893617 3.49404817696129 0.111864940613486 0.437834528769577 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0005131 growth hormone receptor binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0005381 iron ion transmembrane transporter activity 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0008190 eukaryotic initiation factor 4E binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0030957 Tat protein binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0032395 MHC class II receptor activity 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0035374 chondroitin sulfate binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0042975 peroxisome proliferator activated receptor binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0047429 nucleoside triphosphate diphosphatase activity 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0050815 phosphoserine residue binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:1905394 retromer complex binding 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:1990757 ubiquitin ligase activator activity 1/227 10/18639 0.1 8.21101321585903 0.115351699689251 0.437834528769577 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/227 48/18639 0.0416666666666667 3.42125550660793 0.115831949994677 0.437834528769577 GO:0008170 N-methyltransferase activity 3/227 98/18639 0.0306122448979592 2.51357547424256 0.117570378157327 0.437834528769577 GO:0005006 epidermal growth factor receptor activity 2/227 50/18639 0.04 3.28440528634361 0.123870643926867 0.437834528769577 GO:0003953 NAD+ nucleosidase activity 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0005114 type II transforming growth factor beta receptor binding 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0008172 S-methyltransferase activity 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0008526 phosphatidylinositol transfer activity 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0015173 aromatic amino acid transmembrane transporter activity 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0034056 estrogen response element binding 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0034713 type I transforming growth factor beta receptor binding 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0042608 T cell receptor binding 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0050786 RAGE receptor binding 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/227 11/18639 0.0909090909090909 7.46455746896276 0.126131406821708 0.437834528769577 GO:0005030 neurotrophin receptor activity 2/227 51/18639 0.0392156862745098 3.22000518268982 0.127939478214434 0.437834528769577 GO:0031267 small GTPase binding 6/227 283/18639 0.0212014134275618 1.74085085848601 0.132625482283783 0.437834528769577 GO:0004864 protein phosphatase inhibitor activity 2/227 53/18639 0.0377358490566038 3.09849555315435 0.136169214351748 0.437834528769577 GO:0005246 calcium channel regulator activity 2/227 53/18639 0.0377358490566038 3.09849555315435 0.136169214351748 0.437834528769577 GO:0004300 enoyl-CoA hydratase activity 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0005025 transforming growth factor beta receptor activity, type I 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0005026 transforming growth factor beta receptor activity, type II 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0005078 MAP-kinase scaffold activity 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0005095 GTPase inhibitor activity 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0005165 neurotrophin receptor binding 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0008504 monoamine transmembrane transporter activity 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0015269 calcium-activated potassium channel activity 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0016361 activin receptor activity, type I 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0016362 activin receptor activity, type II 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0017002 activin receptor activity 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0017166 vinculin binding 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0035259 nuclear glucocorticoid receptor binding 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0070679 inositol 1,4,5 trisphosphate binding 1/227 12/18639 0.0833333333333333 6.84251101321586 0.136780331593635 0.437834528769577 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/227 13/18639 0.0769230769230769 6.31616401219926 0.14730005375653 0.453285672671062 GO:0008035 high-density lipoprotein particle binding 1/227 13/18639 0.0769230769230769 6.31616401219926 0.14730005375653 0.453285672671062 GO:0035325 Toll-like receptor binding 1/227 13/18639 0.0769230769230769 6.31616401219926 0.14730005375653 0.453285672671062 GO:0035673 oligopeptide transmembrane transporter activity 1/227 13/18639 0.0769230769230769 6.31616401219926 0.14730005375653 0.453285672671062 GO:0043560 insulin receptor substrate binding 1/227 13/18639 0.0769230769230769 6.31616401219926 0.14730005375653 0.453285672671062 GO:0046975 histone H3K36 methyltransferase activity 1/227 13/18639 0.0769230769230769 6.31616401219926 0.14730005375653 0.453285672671062 GO:0070123 transforming growth factor beta receptor activity, type III 1/227 13/18639 0.0769230769230769 6.31616401219926 0.14730005375653 0.453285672671062 GO:0071837 HMG box domain binding 1/227 13/18639 0.0769230769230769 6.31616401219926 0.14730005375653 0.453285672671062 GO:0019212 phosphatase inhibitor activity 2/227 56/18639 0.0357142857142857 2.93250471994965 0.148724114046714 0.455467599268061 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/227 58/18639 0.0344827586206897 2.8313838675376 0.157219424242489 0.459325776786182 GO:0008195 phosphatidate phosphatase activity 1/227 14/18639 0.0714285714285714 5.86500943989931 0.157692134063481 0.459325776786182 GO:0008559 ABC-type xenobiotic transporter activity 1/227 14/18639 0.0714285714285714 5.86500943989931 0.157692134063481 0.459325776786182 GO:0019992 diacylglycerol binding 1/227 14/18639 0.0714285714285714 5.86500943989931 0.157692134063481 0.459325776786182 GO:0044548 S100 protein binding 1/227 14/18639 0.0714285714285714 5.86500943989931 0.157692134063481 0.459325776786182 GO:0071933 Arp2/3 complex binding 1/227 14/18639 0.0714285714285714 5.86500943989931 0.157692134063481 0.459325776786182 GO:0098821 BMP receptor activity 1/227 14/18639 0.0714285714285714 5.86500943989931 0.157692134063481 0.459325776786182 GO:1901474 azole transmembrane transporter activity 1/227 14/18639 0.0714285714285714 5.86500943989931 0.157692134063481 0.459325776786182 GO:1901612 cardiolipin binding 1/227 14/18639 0.0714285714285714 5.86500943989931 0.157692134063481 0.459325776786182 GO:0005125 cytokine activity 5/227 234/18639 0.0213675213675214 1.75449000338868 0.15786719962866 0.459325776786182 GO:0140030 modification-dependent protein binding 4/227 173/18639 0.023121387283237 1.89850016551654 0.160820836611562 0.459325776786182 GO:0004879 nuclear receptor activity 2/227 59/18639 0.0338983050847458 2.78339431046069 0.161501040463743 0.459325776786182 GO:0015459 potassium channel regulator activity 2/227 59/18639 0.0338983050847458 2.78339431046069 0.161501040463743 0.459325776786182 GO:0003823 antigen binding 4/227 174/18639 0.0229885057471264 1.88758924502506 0.163146360000829 0.459325776786182 GO:0001221 transcription coregulator binding 3/227 115/18639 0.0260869565217391 2.1420034476154 0.165282573342456 0.459325776786182 GO:0098531 ligand-modulated transcription factor activity 2/227 60/18639 0.0333333333333333 2.73700440528634 0.16580373420073 0.459325776786182 GO:0004089 carbonate dehydratase activity 1/227 15/18639 0.0666666666666667 5.47400881057269 0.167958114496641 0.459325776786182 GO:0004129 cytochrome-c oxidase activity 1/227 15/18639 0.0666666666666667 5.47400881057269 0.167958114496641 0.459325776786182 GO:0008020 G protein-coupled photoreceptor activity 1/227 15/18639 0.0666666666666667 5.47400881057269 0.167958114496641 0.459325776786182 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/227 15/18639 0.0666666666666667 5.47400881057269 0.167958114496641 0.459325776786182 GO:0031005 filamin binding 1/227 15/18639 0.0666666666666667 5.47400881057269 0.167958114496641 0.459325776786182 GO:0045504 dynein heavy chain binding 1/227 15/18639 0.0666666666666667 5.47400881057269 0.167958114496641 0.459325776786182 GO:0051371 muscle alpha-actinin binding 1/227 15/18639 0.0666666666666667 5.47400881057269 0.167958114496641 0.459325776786182 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/227 61/18639 0.0327868852459016 2.69213548060952 0.170126364225807 0.459325776786182 GO:0016836 hydro-lyase activity 2/227 61/18639 0.0327868852459016 2.69213548060952 0.170126364225807 0.459325776786182 GO:0019905 syntaxin binding 2/227 61/18639 0.0327868852459016 2.69213548060952 0.170126364225807 0.459325776786182 GO:0015179 L-amino acid transmembrane transporter activity 2/227 62/18639 0.032258064516129 2.64871394059969 0.174467813753802 0.459325776786182 GO:0004708 MAP kinase kinase activity 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0015378 sodium:chloride symporter activity 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0015562 efflux transmembrane transporter activity 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0016722 oxidoreductase activity, acting on metal ions 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0022858 alanine transmembrane transporter activity 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0043023 ribosomal large subunit binding 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0097027 ubiquitin-protein transferase activator activity 1/227 16/18639 0.0625 5.13188325991189 0.178099518491983 0.459325776786182 GO:0005507 copper ion binding 2/227 63/18639 0.0317460317460317 2.60667086217747 0.178826990020366 0.459325776786182 GO:1901682 sulfur compound transmembrane transporter activity 2/227 63/18639 0.0317460317460317 2.60667086217747 0.178826990020366 0.459325776786182 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0005092 GDP-dissociation inhibitor activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0008569 minus-end-directed microtubule motor activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0009881 photoreceptor activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0015278 intracellularly gated calcium channel activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0016018 cyclosporin A binding 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0016805 dipeptidase activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0030548 acetylcholine receptor regulator activity 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0036041 long-chain fatty acid binding 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0070492 oligosaccharide binding 1/227 17/18639 0.0588235294117647 4.83000777403472 0.188117851161387 0.460888735345399 GO:0022804 active transmembrane transporter activity 8/227 457/18639 0.0175054704595186 1.43737649292937 0.195310050188512 0.465443911030211 GO:0008525 phosphatidylcholine transporter activity 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0015172 acidic amino acid transmembrane transporter activity 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0015373 monoatomic anion:sodium symporter activity 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0017075 syntaxin-1 binding 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0035615 clathrin adaptor activity 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0098641 cadherin binding involved in cell-cell adhesion 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0099602 neurotransmitter receptor regulator activity 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:1990381 ubiquitin-specific protease binding 1/227 18/18639 0.0555555555555556 4.56167400881057 0.198014599512068 0.465443911030211 GO:0019887 protein kinase regulator activity 5/227 255/18639 0.0196078431372549 1.61000259134491 0.200729036114993 0.468655029217561 GO:0003777 microtubule motor activity 2/227 68/18639 0.0294117647058824 2.41500388701736 0.200852155378955 0.468655029217561 GO:0019902 phosphatase binding 4/227 190/18639 0.0210526315789474 1.72863436123348 0.201897989654683 0.469375983248296 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/227 19/18639 0.0526315789473684 4.3215859030837 0.20779123266339 0.471042758742275 GO:0030506 ankyrin binding 1/227 19/18639 0.0526315789473684 4.3215859030837 0.20779123266339 0.471042758742275 GO:0034987 immunoglobulin receptor binding 1/227 19/18639 0.0526315789473684 4.3215859030837 0.20779123266339 0.471042758742275 GO:0042577 lipid phosphatase activity 1/227 19/18639 0.0526315789473684 4.3215859030837 0.20779123266339 0.471042758742275 GO:0042834 peptidoglycan binding 1/227 19/18639 0.0526315789473684 4.3215859030837 0.20779123266339 0.471042758742275 GO:0043395 heparan sulfate proteoglycan binding 1/227 19/18639 0.0526315789473684 4.3215859030837 0.20779123266339 0.471042758742275 GO:0046624 sphingolipid transporter activity 1/227 19/18639 0.0526315789473684 4.3215859030837 0.20779123266339 0.471042758742275 GO:0001972 retinoic acid binding 1/227 20/18639 0.05 4.10550660792952 0.217449202061102 0.482631155794154 GO:0005326 neurotransmitter transmembrane transporter activity 1/227 20/18639 0.05 4.10550660792952 0.217449202061102 0.482631155794154 GO:0016004 phospholipase activator activity 1/227 20/18639 0.05 4.10550660792952 0.217449202061102 0.482631155794154 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/227 20/18639 0.05 4.10550660792952 0.217449202061102 0.482631155794154 GO:0052745 inositol phosphate phosphatase activity 1/227 20/18639 0.05 4.10550660792952 0.217449202061102 0.482631155794154 GO:0140939 histone H4 methyltransferase activity 1/227 20/18639 0.05 4.10550660792952 0.217449202061102 0.482631155794154 GO:0043539 protein serine/threonine kinase activator activity 2/227 73/18639 0.0273972602739726 2.24959266187919 0.223169678192564 0.493607934057859 GO:0010314 phosphatidylinositol-5-phosphate binding 1/227 21/18639 0.0476190476190476 3.91000629326621 0.226989941689016 0.495180112520217 GO:0035613 RNA stem-loop binding 1/227 21/18639 0.0476190476190476 3.91000629326621 0.226989941689016 0.495180112520217 GO:0061891 calcium ion sensor activity 1/227 21/18639 0.0476190476190476 3.91000629326621 0.226989941689016 0.495180112520217 GO:0140312 cargo adaptor activity 1/227 21/18639 0.0476190476190476 3.91000629326621 0.226989941689016 0.495180112520217 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 5/227 268/18639 0.0186567164179104 1.53190545071997 0.229046686726706 0.497961568071371 GO:0005243 gap junction channel activity 1/227 22/18639 0.0454545454545455 3.73227873448138 0.236414868278155 0.505356614406661 GO:0015377 chloride:monoatomic cation symporter activity 1/227 22/18639 0.0454545454545455 3.73227873448138 0.236414868278155 0.505356614406661 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/227 22/18639 0.0454545454545455 3.73227873448138 0.236414868278155 0.505356614406661 GO:0061133 endopeptidase activator activity 1/227 22/18639 0.0454545454545455 3.73227873448138 0.236414868278155 0.505356614406661 GO:0140784 metal ion sensor activity 1/227 22/18639 0.0454545454545455 3.73227873448138 0.236414868278155 0.505356614406661 GO:0030295 protein kinase activator activity 3/227 139/18639 0.0215827338129496 1.77216112572497 0.240069976208271 0.511453427574143 GO:0140297 DNA-binding transcription factor binding 8/227 488/18639 0.0163934426229508 1.34606774030476 0.245394824043607 0.514891671131731 GO:0005283 amino acid:sodium symporter activity 1/227 23/18639 0.0434782608695652 3.57000574602567 0.245725381513416 0.514891671131731 GO:0017134 fibroblast growth factor binding 1/227 23/18639 0.0434782608695652 3.57000574602567 0.245725381513416 0.514891671131731 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/227 23/18639 0.0434782608695652 3.57000574602567 0.245725381513416 0.514891671131731 GO:0099186 structural constituent of postsynapse 1/227 23/18639 0.0434782608695652 3.57000574602567 0.245725381513416 0.514891671131731 GO:0015370 solute:sodium symporter activity 2/227 79/18639 0.0253164556962025 2.07873752300229 0.2501798642627 0.5167549973664 GO:0016835 carbon-oxygen lyase activity 2/227 79/18639 0.0253164556962025 2.07873752300229 0.2501798642627 0.5167549973664 GO:0001217 DNA-binding transcription repressor activity 5/227 278/18639 0.0179856115107914 1.47680093810414 0.251578072341406 0.5167549973664 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 6/227 349/18639 0.0171919770773639 1.4116355098898 0.253160890707303 0.5167549973664 GO:0004622 lysophospholipase activity 1/227 24/18639 0.0416666666666667 3.42125550660793 0.254922864237764 0.5167549973664 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/227 24/18639 0.0416666666666667 3.42125550660793 0.254922864237764 0.5167549973664 GO:0019957 C-C chemokine binding 1/227 24/18639 0.0416666666666667 3.42125550660793 0.254922864237764 0.5167549973664 GO:0048027 mRNA 5'-UTR binding 1/227 24/18639 0.0416666666666667 3.42125550660793 0.254922864237764 0.5167549973664 GO:0060229 lipase activator activity 1/227 24/18639 0.0416666666666667 3.42125550660793 0.254922864237764 0.5167549973664 GO:0070300 phosphatidic acid binding 1/227 24/18639 0.0416666666666667 3.42125550660793 0.254922864237764 0.5167549973664 GO:0030246 carbohydrate binding 5/227 280/18639 0.0178571428571429 1.46625235997483 0.256151586776256 0.5167549973664 GO:0019903 protein phosphatase binding 3/227 144/18639 0.0208333333333333 1.71062775330396 0.256349417845812 0.5167549973664 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/227 25/18639 0.04 3.28440528634361 0.264008682653989 0.522278046119848 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/227 25/18639 0.04 3.28440528634361 0.264008682653989 0.522278046119848 GO:0017025 TBP-class protein binding 1/227 25/18639 0.04 3.28440528634361 0.264008682653989 0.522278046119848 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/227 25/18639 0.04 3.28440528634361 0.264008682653989 0.522278046119848 GO:0019707 protein-cysteine S-acyltransferase activity 1/227 25/18639 0.04 3.28440528634361 0.264008682653989 0.522278046119848 GO:0120020 cholesterol transfer activity 1/227 25/18639 0.04 3.28440528634361 0.264008682653989 0.522278046119848 GO:0004860 protein kinase inhibitor activity 2/227 84/18639 0.0238095238095238 1.9550031466331 0.272763577625162 0.523767851854903 GO:0004435 phosphatidylinositol phospholipase C activity 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0005227 calcium-activated cation channel activity 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0030507 spectrin binding 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0043548 phosphatidylinositol 3-kinase binding 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0050681 nuclear androgen receptor binding 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0050750 low-density lipoprotein particle receptor binding 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0052742 phosphatidylinositol kinase activity 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0070006 metalloaminopeptidase activity 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0120014 phospholipid transfer activity 1/227 26/18639 0.0384615384615385 3.15808200609963 0.272984186524062 0.523767851854903 GO:0050660 flavin adenine dinucleotide binding 2/227 86/18639 0.0232558139534884 1.90953795717652 0.281794703870234 0.533066185343792 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/227 27/18639 0.037037037037037 3.04111600587372 0.28185070936611 0.533066185343792 GO:0015252 proton channel activity 1/227 27/18639 0.037037037037037 3.04111600587372 0.28185070936611 0.533066185343792 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/227 27/18639 0.037037037037037 3.04111600587372 0.28185070936611 0.533066185343792 GO:0042578 phosphoric ester hydrolase activity 6/227 363/18639 0.0165289256198347 1.35719226708414 0.282014606688945 0.533066185343792 GO:0045499 chemorepellent activity 1/227 28/18639 0.0357142857142857 2.93250471994965 0.29060956864904 0.542868900966096 GO:0046875 ephrin receptor binding 1/227 28/18639 0.0357142857142857 2.93250471994965 0.29060956864904 0.542868900966096 GO:0051393 alpha-actinin binding 1/227 28/18639 0.0357142857142857 2.93250471994965 0.29060956864904 0.542868900966096 GO:0051959 dynein light intermediate chain binding 1/227 28/18639 0.0357142857142857 2.93250471994965 0.29060956864904 0.542868900966096 GO:0046982 protein heterodimerization activity 6/227 369/18639 0.016260162601626 1.33512410013968 0.294606093486461 0.547244671988393 GO:0004181 metallocarboxypeptidase activity 1/227 29/18639 0.0344827586206897 2.8313838675376 0.299262065984845 0.547244671988393 GO:0004629 phospholipase C activity 1/227 29/18639 0.0344827586206897 2.8313838675376 0.299262065984845 0.547244671988393 GO:0005416 amino acid:monoatomic cation symporter activity 1/227 29/18639 0.0344827586206897 2.8313838675376 0.299262065984845 0.547244671988393 GO:0016417 S-acyltransferase activity 1/227 29/18639 0.0344827586206897 2.8313838675376 0.299262065984845 0.547244671988393 GO:0099604 ligand-gated calcium channel activity 1/227 29/18639 0.0344827586206897 2.8313838675376 0.299262065984845 0.547244671988393 GO:0106222 lncRNA binding 1/227 29/18639 0.0344827586206897 2.8313838675376 0.299262065984845 0.547244671988393 GO:0019210 kinase inhibitor activity 2/227 90/18639 0.0222222222222222 1.82466960352423 0.2998247888916 0.547244671988393 GO:0031625 ubiquitin protein ligase binding 5/227 302/18639 0.0165562913907285 1.35943927414885 0.307614991934537 0.549228693058704 GO:0005085 guanyl-nucleotide exchange factor activity 4/227 230/18639 0.0173913043478261 1.42800229841027 0.307738806390252 0.549228693058704 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/227 30/18639 0.0333333333333333 2.73700440528634 0.307809487318615 0.549228693058704 GO:0022839 monoatomic ion-gated channel activity 1/227 30/18639 0.0333333333333333 2.73700440528634 0.307809487318615 0.549228693058704 GO:0031210 phosphatidylcholine binding 1/227 30/18639 0.0333333333333333 2.73700440528634 0.307809487318615 0.549228693058704 GO:0051721 protein phosphatase 2A binding 1/227 30/18639 0.0333333333333333 2.73700440528634 0.307809487318615 0.549228693058704 GO:0070566 adenylyltransferase activity 1/227 30/18639 0.0333333333333333 2.73700440528634 0.307809487318615 0.549228693058704 GO:0098918 structural constituent of synapse 1/227 30/18639 0.0333333333333333 2.73700440528634 0.307809487318615 0.549228693058704 GO:0099106 ion channel regulator activity 3/227 160/18639 0.01875 1.53956497797357 0.309249532452774 0.550256849643622 GO:0005184 neuropeptide hormone activity 1/227 31/18639 0.032258064516129 2.64871394059969 0.316253103116276 0.553442930453482 GO:0017147 Wnt-protein binding 1/227 31/18639 0.032258064516129 2.64871394059969 0.316253103116276 0.553442930453482 GO:0047499 calcium-independent phospholipase A2 activity 1/227 31/18639 0.032258064516129 2.64871394059969 0.316253103116276 0.553442930453482 GO:0070273 phosphatidylinositol-4-phosphate binding 1/227 31/18639 0.032258064516129 2.64871394059969 0.316253103116276 0.553442930453482 GO:0070325 lipoprotein particle receptor binding 1/227 31/18639 0.032258064516129 2.64871394059969 0.316253103116276 0.553442930453482 GO:0072349 modified amino acid transmembrane transporter activity 1/227 31/18639 0.032258064516129 2.64871394059969 0.316253103116276 0.553442930453482 GO:0042910 xenobiotic transmembrane transporter activity 1/227 32/18639 0.03125 2.56594162995595 0.3245941685501 0.561865449365254 GO:0047498 calcium-dependent phospholipase A2 activity 1/227 32/18639 0.03125 2.56594162995595 0.3245941685501 0.561865449365254 GO:0120015 sterol transfer activity 1/227 32/18639 0.03125 2.56594162995595 0.3245941685501 0.561865449365254 GO:0160041 neuropeptide activity 1/227 32/18639 0.03125 2.56594162995595 0.3245941685501 0.561865449365254 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 3/227 167/18639 0.0179640718562874 1.47503231422617 0.332563750049163 0.573014079420079 GO:0140311 protein sequestering activity 1/227 33/18639 0.0303030303030303 2.48818582298759 0.332833923681992 0.573014079420079 GO:0016247 channel regulator activity 3/227 168/18639 0.0178571428571429 1.46625235997483 0.335894317599021 0.576724205688885 GO:0008376 acetylgalactosaminyltransferase activity 1/227 34/18639 0.0294117647058824 2.41500388701736 0.340973593644595 0.57920047773762 GO:0051427 hormone receptor binding 1/227 34/18639 0.0294117647058824 2.41500388701736 0.340973593644595 0.57920047773762 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/227 34/18639 0.0294117647058824 2.41500388701736 0.340973593644595 0.57920047773762 GO:0090482 vitamin transmembrane transporter activity 1/227 34/18639 0.0294117647058824 2.41500388701736 0.340973593644595 0.57920047773762 GO:0141108 transporter regulator activity 3/227 170/18639 0.0176470588235294 1.44900233221042 0.342552964853395 0.580335740988331 GO:0004623 phospholipase A2 activity 1/227 35/18639 0.0285714285714286 2.34600377595972 0.34901438882023 0.584529384823335 GO:0005154 epidermal growth factor receptor binding 1/227 35/18639 0.0285714285714286 2.34600377595972 0.34901438882023 0.584529384823335 GO:0005343 organic acid:sodium symporter activity 1/227 35/18639 0.0285714285714286 2.34600377595972 0.34901438882023 0.584529384823335 GO:0015171 amino acid transmembrane transporter activity 2/227 102/18639 0.0196078431372549 1.61000259134491 0.353338553783592 0.584529384823335 GO:0044389 ubiquitin-like protein ligase binding 5/227 322/18639 0.015527950310559 1.27500205215202 0.355585629764006 0.584529384823335 GO:0004190 aspartic-type endopeptidase activity 1/227 36/18639 0.0277777777777778 2.28083700440529 0.356957505017704 0.584529384823335 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/227 36/18639 0.0277777777777778 2.28083700440529 0.356957505017704 0.584529384823335 GO:0016409 palmitoyltransferase activity 1/227 36/18639 0.0277777777777778 2.28083700440529 0.356957505017704 0.584529384823335 GO:0045505 dynein intermediate chain binding 1/227 36/18639 0.0277777777777778 2.28083700440529 0.356957505017704 0.584529384823335 GO:0055106 ubiquitin-protein transferase regulator activity 1/227 36/18639 0.0277777777777778 2.28083700440529 0.356957505017704 0.584529384823335 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/227 36/18639 0.0277777777777778 2.28083700440529 0.356957505017704 0.584529384823335 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/227 36/18639 0.0277777777777778 2.28083700440529 0.356957505017704 0.584529384823335 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/227 36/18639 0.0277777777777778 2.28083700440529 0.356957505017704 0.584529384823335 GO:0022829 wide pore channel activity 1/227 37/18639 0.027027027027027 2.21919276104298 0.36480412364701 0.592806700926391 GO:0042805 actinin binding 1/227 37/18639 0.027027027027027 2.21919276104298 0.36480412364701 0.592806700926391 GO:0070001 aspartic-type peptidase activity 1/227 37/18639 0.027027027027027 2.21919276104298 0.36480412364701 0.592806700926391 GO:0005319 lipid transporter activity 3/227 178/18639 0.0168539325842697 1.38387863188635 0.369120271570382 0.59777782714147 GO:0000149 SNARE binding 2/227 106/18639 0.0188679245283019 1.54924777657718 0.370881829445451 0.59777782714147 GO:0005109 frizzled binding 1/227 38/18639 0.0263157894736842 2.16079295154185 0.372555411891937 0.59777782714147 GO:0042887 amide transmembrane transporter activity 1/227 38/18639 0.0263157894736842 2.16079295154185 0.372555411891937 0.59777782714147 GO:0043531 ADP binding 1/227 38/18639 0.0263157894736842 2.16079295154185 0.372555411891937 0.59777782714147 GO:0019888 protein phosphatase regulator activity 2/227 107/18639 0.0186915887850467 1.53476882539421 0.375238738061676 0.600570543078612 GO:0005496 steroid binding 2/227 108/18639 0.0185185185185185 1.52055800293686 0.379583352622306 0.602476062375512 GO:0000217 DNA secondary structure binding 1/227 39/18639 0.0256410256410256 2.10538800406642 0.380212522880622 0.602476062375512 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/227 39/18639 0.0256410256410256 2.10538800406642 0.380212522880622 0.602476062375512 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/227 39/18639 0.0256410256410256 2.10538800406642 0.380212522880622 0.602476062375512 GO:0004620 phospholipase activity 2/227 109/18639 0.018348623853211 1.50660792951542 0.383915326540152 0.606833903240885 GO:0004177 aminopeptidase activity 1/227 40/18639 0.025 2.05275330396476 0.387776595854068 0.606913247073812 GO:0050997 quaternary ammonium group binding 1/227 40/18639 0.025 2.05275330396476 0.387776595854068 0.606913247073812 GO:0071855 neuropeptide receptor binding 1/227 40/18639 0.025 2.05275330396476 0.387776595854068 0.606913247073812 GO:0071949 FAD binding 1/227 40/18639 0.025 2.05275330396476 0.387776595854068 0.606913247073812 GO:1901981 phosphatidylinositol phosphate binding 3/227 185/18639 0.0162162162162162 1.33151565662579 0.392213179565171 0.611100625689071 GO:0001530 lipopolysaccharide binding 1/227 41/18639 0.024390243902439 2.00268615020952 0.395248756332649 0.611100625689071 GO:0001727 lipid kinase activity 1/227 41/18639 0.024390243902439 2.00268615020952 0.395248756332649 0.611100625689071 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/227 41/18639 0.024390243902439 2.00268615020952 0.395248756332649 0.611100625689071 GO:0042287 MHC protein binding 1/227 41/18639 0.024390243902439 2.00268615020952 0.395248756332649 0.611100625689071 GO:0016887 ATP hydrolysis activity 6/227 417/18639 0.0143884892086331 1.18144075048331 0.398027100836226 0.613906206374518 GO:0016859 cis-trans isomerase activity 1/227 42/18639 0.0238095238095238 1.9550031466331 0.402630116280626 0.615048882663691 GO:0019894 kinesin binding 1/227 42/18639 0.0238095238095238 1.9550031466331 0.402630116280626 0.615048882663691 GO:0031492 nucleosomal DNA binding 1/227 42/18639 0.0238095238095238 1.9550031466331 0.402630116280626 0.615048882663691 GO:0051879 Hsp90 protein binding 1/227 42/18639 0.0238095238095238 1.9550031466331 0.402630116280626 0.615048882663691 GO:0035401 histone H3Y41 kinase activity 2/227 115/18639 0.0173913043478261 1.42800229841027 0.40962356657396 0.620237933988516 GO:0140801 histone H2AXY142 kinase activity 2/227 115/18639 0.0173913043478261 1.42800229841027 0.40962356657396 0.620237933988516 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/227 43/18639 0.0232558139534884 1.90953795717652 0.409921774268705 0.620237933988516 GO:0048156 tau protein binding 1/227 43/18639 0.0232558139534884 1.90953795717652 0.409921774268705 0.620237933988516 GO:0015294 solute:monoatomic cation symporter activity 2/227 116/18639 0.0172413793103448 1.4156919337688 0.413858182866094 0.624710100677018 GO:0001046 core promoter sequence-specific DNA binding 1/227 44/18639 0.0227272727272727 1.86613936724069 0.417124815634644 0.628102637118112 GO:0019208 phosphatase regulator activity 2/227 117/18639 0.0170940170940171 1.40359200271095 0.418077736480501 0.628102637118112 GO:0042605 peptide antigen binding 1/227 45/18639 0.0222222222222222 1.82466960352423 0.424240312641954 0.634368730405927 GO:0046915 transition metal ion transmembrane transporter activity 1/227 45/18639 0.0222222222222222 1.82466960352423 0.424240312641954 0.634368730405927 GO:0030276 clathrin binding 1/227 46/18639 0.0217391304347826 1.78500287301283 0.431269324636699 0.641040273207036 GO:0030291 protein serine/threonine kinase inhibitor activity 1/227 46/18639 0.0217391304347826 1.78500287301283 0.431269324636699 0.641040273207036 GO:0043495 protein-membrane adaptor activity 1/227 47/18639 0.0212765957446809 1.74702408848064 0.438212898202421 0.641040273207036 GO:0061749 forked DNA-dependent helicase activity 1/227 47/18639 0.0212765957446809 1.74702408848064 0.438212898202421 0.641040273207036 GO:0140359 ABC-type transporter activity 1/227 47/18639 0.0212765957446809 1.74702408848064 0.438212898202421 0.641040273207036 GO:0140938 histone H3 methyltransferase activity 1/227 47/18639 0.0212765957446809 1.74702408848064 0.438212898202421 0.641040273207036 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/227 47/18639 0.0212765957446809 1.74702408848064 0.438212898202421 0.641040273207036 GO:0009378 four-way junction helicase activity 1/227 48/18639 0.0208333333333333 1.71062775330396 0.445072067313224 0.641040273207036 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/227 48/18639 0.0208333333333333 1.71062775330396 0.445072067313224 0.641040273207036 GO:0032266 phosphatidylinositol-3-phosphate binding 1/227 48/18639 0.0208333333333333 1.71062775330396 0.445072067313224 0.641040273207036 GO:0036121 double-stranded DNA helicase activity 1/227 48/18639 0.0208333333333333 1.71062775330396 0.445072067313224 0.641040273207036 GO:0043138 3'-5' DNA helicase activity 1/227 48/18639 0.0208333333333333 1.71062775330396 0.445072067313224 0.641040273207036 GO:0001222 transcription corepressor binding 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0005004 GPI-linked ephrin receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0005008 hepatocyte growth factor receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0005009 insulin receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0005011 macrophage colony-stimulating factor receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0005020 stem cell factor receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0008288 boss receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0036332 placental growth factor receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0038062 protein tyrosine kinase collagen receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0060175 brain-derived neurotrophic factor receptor activity 1/227 49/18639 0.0204081632653061 1.67571698282837 0.451847853485022 0.641040273207036 GO:0008168 methyltransferase activity 3/227 204/18639 0.0147058823529412 1.20750194350868 0.453632377580026 0.642141832263281 GO:0005007 fibroblast growth factor receptor activity 1/227 50/18639 0.02 1.64220264317181 0.458541265924984 0.644792022945287 GO:0005017 platelet-derived growth factor receptor activity 1/227 50/18639 0.02 1.64220264317181 0.458541265924984 0.644792022945287 GO:0005019 platelet-derived growth factor beta-receptor activity 1/227 50/18639 0.02 1.64220264317181 0.458541265924984 0.644792022945287 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 2/227 128/18639 0.015625 1.28297081497797 0.463429746374162 0.648364667767281 GO:0003743 translation initiation factor activity 1/227 51/18639 0.0196078431372549 1.61000259134491 0.465153301679195 0.648364667767281 GO:0005010 insulin-like growth factor receptor activity 1/227 51/18639 0.0196078431372549 1.61000259134491 0.465153301679195 0.648364667767281 GO:0016597 amino acid binding 1/227 51/18639 0.0196078431372549 1.61000259134491 0.465153301679195 0.648364667767281 GO:0016298 lipase activity 2/227 130/18639 0.0153846153846154 1.26323280243985 0.471453337018324 0.652191387946285 GO:0005080 protein kinase C binding 1/227 52/18639 0.0192307692307692 1.57904100304981 0.471684945778551 0.652191387946285 GO:0030159 signaling receptor complex adaptor activity 1/227 52/18639 0.0192307692307692 1.57904100304981 0.471684945778551 0.652191387946285 GO:0005003 ephrin receptor activity 1/227 53/18639 0.0188679245283019 1.54924777657718 0.478137171382912 0.652191387946285 GO:0005005 transmembrane-ephrin receptor activity 1/227 53/18639 0.0188679245283019 1.54924777657718 0.478137171382912 0.652191387946285 GO:0005544 calcium-dependent phospholipid binding 1/227 53/18639 0.0188679245283019 1.54924777657718 0.478137171382912 0.652191387946285 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/227 53/18639 0.0188679245283019 1.54924777657718 0.478137171382912 0.652191387946285 GO:0038064 collagen receptor activity 1/227 53/18639 0.0188679245283019 1.54924777657718 0.478137171382912 0.652191387946285 GO:0051018 protein kinase A binding 1/227 53/18639 0.0188679245283019 1.54924777657718 0.478137171382912 0.652191387946285 GO:0140296 general transcription initiation factor binding 1/227 53/18639 0.0188679245283019 1.54924777657718 0.478137171382912 0.652191387946285 GO:0015485 cholesterol binding 1/227 54/18639 0.0185185185185185 1.52055800293686 0.484510939923539 0.659473223784817 GO:0016741 transferase activity, transferring one-carbon groups 3/227 215/18639 0.013953488372093 1.14572277430591 0.488020264662844 0.662381752526083 GO:0001664 G protein-coupled receptor binding 4/227 297/18639 0.0134680134680135 1.10586036577226 0.49024709250681 0.662381752526083 GO:0008374 O-acyltransferase activity 1/227 55/18639 0.0181818181818182 1.49291149379255 0.490807201243816 0.662381752526083 GO:0140313 molecular sequestering activity 1/227 55/18639 0.0181818181818182 1.49291149379255 0.490807201243816 0.662381752526083 GO:0099094 ligand-gated monoatomic cation channel activity 2/227 136/18639 0.0147058823529412 1.20750194350868 0.495087177019225 0.666745310277477 GO:0016922 nuclear receptor binding 2/227 137/18639 0.0145985401459854 1.19868806070935 0.498960937553564 0.670544551100465 GO:0140767 enzyme-substrate adaptor activity 2/227 139/18639 0.0143884892086331 1.18144075048331 0.506651431417826 0.679446235396116 GO:0017116 single-stranded DNA helicase activity 1/227 58/18639 0.0172413793103448 1.4156919337688 0.509240269406773 0.681483301706122 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1/227 59/18639 0.0169491525423729 1.39169715523034 0.515235773354066 0.685188283145178 GO:0036002 pre-mRNA binding 1/227 59/18639 0.0169491525423729 1.39169715523034 0.515235773354066 0.685188283145178 GO:0070888 E-box binding 1/227 59/18639 0.0169491525423729 1.39169715523034 0.515235773354066 0.685188283145178 GO:0020037 heme binding 2/227 142/18639 0.0140845070422535 1.15648073462803 0.518042976526438 0.687486200098627 GO:0015293 symporter activity 2/227 146/18639 0.0136986301369863 1.12479633093959 0.532958539575543 0.705809957816259 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 6/227 484/18639 0.012396694214876 1.0178942003131 0.540038792340772 0.713702719338324 GO:0120013 lipid transfer activity 1/227 65/18639 0.0153846153846154 1.26323280243985 0.549707870999708 0.724977047260484 GO:0001216 DNA-binding transcription activator activity 6/227 491/18639 0.0122199592668024 1.00338247036974 0.554131584262986 0.728592168147356 GO:0046906 tetrapyrrole binding 2/227 152/18639 0.0131578947368421 1.08039647577093 0.554736580143591 0.728592168147356 GO:0016500 protein-hormone receptor activity 1/227 67/18639 0.0149253731343284 1.22552436057597 0.560647293736063 0.733331265112674 GO:0042054 histone methyltransferase activity 1/227 67/18639 0.0149253731343284 1.22552436057597 0.560647293736063 0.733331265112674 GO:0005548 phospholipid transporter activity 1/227 68/18639 0.0147058823529412 1.20750194350868 0.56601737042796 0.735822581556348 GO:0032934 sterol binding 1/227 68/18639 0.0147058823529412 1.20750194350868 0.56601737042796 0.735822581556348 GO:0140223 general transcription initiation factor activity 1/227 68/18639 0.0147058823529412 1.20750194350868 0.56601737042796 0.735822581556348 GO:0016279 protein-lysine N-methyltransferase activity 1/227 69/18639 0.0144927536231884 1.19000191534189 0.57132209590924 0.741206059254962 GO:0016278 lysine N-methyltransferase activity 1/227 70/18639 0.0142857142857143 1.17300188797986 0.576562261995864 0.746484066852369 GO:0140299 molecular sensor activity 1/227 71/18639 0.0140845070422535 1.15648073462803 0.581738650952024 0.751658256909614 GO:0015081 sodium ion transmembrane transporter activity 2/227 164/18639 0.0121951219512195 1.00134307510476 0.596110810175293 0.765031664070918 GO:0003678 DNA helicase activity 1/227 74/18639 0.0135135135135135 1.10959638052149 0.596892836802585 0.765031664070918 GO:0031491 nucleosome binding 1/227 74/18639 0.0135135135135135 1.10959638052149 0.596892836802585 0.765031664070918 GO:0035064 methylated histone binding 1/227 74/18639 0.0135135135135135 1.10959638052149 0.596892836802585 0.765031664070918 GO:0044183 protein folding chaperone 1/227 75/18639 0.0133333333333333 1.09480176211454 0.60182175282983 0.769800113559442 GO:0016874 ligase activity 2/227 167/18639 0.0119760479041916 0.983354876150782 0.605995944631241 0.771381143316154 GO:0017022 myosin binding 1/227 76/18639 0.0131578947368421 1.08039647577093 0.60669066373845 0.771381143316154 GO:0140034 methylation-dependent protein binding 1/227 76/18639 0.0131578947368421 1.08039647577093 0.60669066373845 0.771381143316154 GO:0030971 receptor tyrosine kinase binding 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:0033192 calmodulin-dependent protein phosphatase activity 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:0140791 histone H2AXS140 phosphatase activity 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:1990439 MAP kinase serine/threonine phosphatase activity 1/227 81/18639 0.0123456790123457 1.01370533529124 0.630160292544272 0.786991008431473 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 1/227 82/18639 0.0121951219512195 1.00134307510476 0.634684142829457 0.786991008431473 GO:0033549 MAP kinase phosphatase activity 1/227 82/18639 0.0121951219512195 1.00134307510476 0.634684142829457 0.786991008431473 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 1/227 83/18639 0.0120481927710843 0.989278700705907 0.639152898532303 0.786991008431473 GO:0008135 translation factor activity, RNA binding 1/227 83/18639 0.0120481927710843 0.989278700705907 0.639152898532303 0.786991008431473 GO:0030165 PDZ domain binding 1/227 83/18639 0.0120481927710843 0.989278700705907 0.639152898532303 0.786991008431473 GO:0008514 organic anion transmembrane transporter activity 3/227 269/18639 0.0111524163568773 0.915726380950821 0.639206793604469 0.786991008431473 GO:0004527 exonuclease activity 1/227 84/18639 0.0119047619047619 0.977501573316551 0.643567227699858 0.786991008431473 GO:0017018 myosin phosphatase activity 1/227 84/18639 0.0119047619047619 0.977501573316551 0.643567227699858 0.786991008431473 GO:0051117 ATPase binding 1/227 84/18639 0.0119047619047619 0.977501573316551 0.643567227699858 0.786991008431473 GO:0180051 translation factor activity 1/227 84/18639 0.0119047619047619 0.977501573316551 0.643567227699858 0.786991008431473 GO:0046873 metal ion transmembrane transporter activity 5/227 450/18639 0.0111111111111111 0.912334801762115 0.643677104227312 0.786991008431473 GO:0016791 phosphatase activity 3/227 273/18639 0.010989010989011 0.902309144599894 0.649080991314713 0.792077761431939 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/227 86/18639 0.0116279069767442 0.954768978588259 0.652235238390176 0.792889020714775 GO:0016209 antioxidant activity 1/227 86/18639 0.0116279069767442 0.954768978588259 0.652235238390176 0.792889020714775 GO:0004197 cysteine-type endopeptidase activity 1/227 88/18639 0.0113636363636364 0.933069683620344 0.660693359717255 0.801641276456936 GO:0015276 ligand-gated monoatomic ion channel activity 2/227 186/18639 0.010752688172043 0.882904646866563 0.664360695942246 0.802095558399548 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/227 89/18639 0.0112359550561798 0.922585754590902 0.664845298014068 0.802095558399548 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 1/227 89/18639 0.0112359550561798 0.922585754590902 0.664845298014068 0.802095558399548 GO:0140793 histone H2AXY142 phosphatase activity 1/227 90/18639 0.0111111111111111 0.912334801762115 0.668946652049152 0.803847622659056 GO:0022834 ligand-gated channel activity 2/227 188/18639 0.0106382978723404 0.873512044240322 0.670083340081568 0.803847622659056 GO:0046943 carboxylic acid transmembrane transporter activity 2/227 188/18639 0.0106382978723404 0.873512044240322 0.670083340081568 0.803847622659056 GO:0005342 organic acid transmembrane transporter activity 2/227 189/18639 0.0105820105820106 0.86889028739249 0.672915071502184 0.805727256667089 GO:0005525 GTP binding 4/227 378/18639 0.0105820105820106 0.86889028739249 0.679145151476516 0.811661278593885 GO:0051213 dioxygenase activity 1/227 93/18639 0.010752688172043 0.882904646866563 0.680953307510386 0.812173817765733 GO:0015291 secondary active transmembrane transporter activity 3/227 287/18639 0.0104529616724739 0.858294064375509 0.682124007071691 0.812173817765733 GO:0008276 protein methyltransferase activity 1/227 95/18639 0.0105263157894737 0.86431718061674 0.688715876414584 0.818492562082258 GO:0004725 protein tyrosine phosphatase activity 1/227 98/18639 0.0102040816326531 0.837858491414187 0.70000854765853 0.82728282905099 GO:0005249 voltage-gated potassium channel activity 1/227 98/18639 0.0102040816326531 0.837858491414187 0.70000854765853 0.82728282905099 GO:0042626 ATPase-coupled transmembrane transporter activity 1/227 98/18639 0.0102040816326531 0.837858491414187 0.70000854765853 0.82728282905099 GO:0016829 lyase activity 2/227 200/18639 0.01 0.821101321585903 0.702780043765963 0.829020162738738 GO:0004722 protein serine/threonine phosphatase activity 1/227 103/18639 0.00970873786407767 0.797185749112527 0.717930417010266 0.84532657233926 GO:0019001 guanyl nucleotide binding 4/227 400/18639 0.01 0.821101321585903 0.721152405127675 0.845992784652539 GO:0032561 guanyl ribonucleotide binding 4/227 400/18639 0.01 0.821101321585903 0.721152405127675 0.845992784652539 GO:0004518 nuclease activity 2/227 209/18639 0.00956937799043062 0.785742891469764 0.725505556715838 0.849534999316156 GO:0008013 beta-catenin binding 1/227 106/18639 0.00943396226415094 0.774623888288588 0.728167614332599 0.851087651981404 GO:1902936 phosphatidylinositol bisphosphate binding 1/227 111/18639 0.00900900900900901 0.73973092034766 0.744414064413119 0.868483075148639 GO:0043022 ribosome binding 1/227 112/18639 0.00892857142857143 0.733126179987413 0.747545433550544 0.87054193998482 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/227 229/18639 0.00873362445414847 0.717119058153627 0.770794101364573 0.894832920791294 GO:0003697 single-stranded DNA binding 1/227 121/18639 0.00826446280991736 0.678596133542069 0.774063366388587 0.894832920791294 GO:0004540 RNA nuclease activity 1/227 121/18639 0.00826446280991736 0.678596133542069 0.774063366388587 0.894832920791294 GO:0015108 chloride transmembrane transporter activity 1/227 121/18639 0.00826446280991736 0.678596133542069 0.774063366388587 0.894832920791294 GO:0004674 protein serine/threonine kinase activity 4/227 433/18639 0.0092378752886836 0.758523160818386 0.776353933572197 0.894832920791294 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/227 122/18639 0.00819672131147541 0.67303387015238 0.776832975192442 0.894832920791294 GO:0005267 potassium channel activity 1/227 124/18639 0.00806451612903226 0.662178485149922 0.782271194330327 0.899470669293173 GO:0005261 monoatomic cation channel activity 3/227 341/18639 0.00879765395894428 0.72237652925446 0.787928759109536 0.904343458653647 GO:0042826 histone deacetylase binding 1/227 127/18639 0.0078740157480315 0.646536473689687 0.790182114126835 0.90529857319927 GO:0031490 chromatin DNA binding 1/227 128/18639 0.0078125 0.641485407488987 0.792754967416226 0.906615644962542 GO:0016798 hydrolase activity, acting on glycosyl bonds 1/227 130/18639 0.00769230769230769 0.631616401219925 0.797806820260415 0.908703298983477 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/227 130/18639 0.00769230769230769 0.631616401219925 0.797806820260415 0.908703298983477 GO:0005262 calcium channel activity 1/227 131/18639 0.00763358778625954 0.626794901973972 0.80028657885358 0.908703298983477 GO:0031072 heat shock protein binding 1/227 131/18639 0.00763358778625954 0.626794901973972 0.80028657885358 0.908703298983477 GO:0042393 histone binding 2/227 247/18639 0.00809716599190283 0.664859369705185 0.805867555396092 0.913412157984538 GO:0141003 histone H2AX kinase activity 3/227 354/18639 0.00847457627118644 0.695848577615172 0.808565033788925 0.914841787786049 GO:0016779 nucleotidyltransferase activity 1/227 136/18639 0.00735294117647059 0.603750971754341 0.812238465368174 0.915075159873805 GO:0140789 histone phosphatase activity 1/227 136/18639 0.00735294117647059 0.603750971754341 0.812238465368174 0.915075159873805 GO:0140996 histone H3 kinase activity 3/227 357/18639 0.00840336134453781 0.690001110576389 0.813080911285045 0.915075159873805 GO:0035173 histone kinase activity 3/227 360/18639 0.00833333333333333 0.684251101321586 0.817506792424604 0.918433556921469 GO:0022843 voltage-gated monoatomic cation channel activity 1/227 143/18639 0.00699300699300699 0.57419672838175 0.827783996550312 0.928342263736882 GO:0008194 UDP-glycosyltransferase activity 1/227 145/18639 0.00689655172413793 0.566276773507519 0.831985357250872 0.931414187291398 GO:0015085 calcium ion transmembrane transporter activity 1/227 147/18639 0.00680272108843537 0.558572327609458 0.836084662605086 0.933864616599167 GO:0008509 monoatomic anion transmembrane transporter activity 1/227 149/18639 0.00671140939597315 0.55107471247376 0.8400843809382 0.933864616599167 GO:0000510 H3-H4 histone complex chaperone activity 1/227 151/18639 0.00662251655629139 0.543775709659538 0.843986921135122 0.933864616599167 GO:0140584 chromatin extrusion motor activity 1/227 151/18639 0.00662251655629139 0.543775709659538 0.843986921135122 0.933864616599167 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 1/227 151/18639 0.00662251655629139 0.543775709659538 0.843986921135122 0.933864616599167 GO:0140849 ATP-dependent H2AZ histone chaperone activity 1/227 151/18639 0.00662251655629139 0.543775709659538 0.843986921135122 0.933864616599167 GO:0015616 DNA translocase activity 1/227 152/18639 0.00657894736842105 0.540198237885463 0.845902486307252 0.933864616599167 GO:0140674 ATP-dependent histone chaperone activity 1/227 152/18639 0.00657894736842105 0.540198237885463 0.845902486307252 0.933864616599167 GO:0061775 cohesin loader activity 1/227 153/18639 0.0065359477124183 0.536667530448303 0.847794634065582 0.934334224740096 GO:0015631 tubulin binding 3/227 385/18639 0.00779220779220779 0.639819211625379 0.851046742844233 0.935192675003877 GO:0004386 helicase activity 1/227 155/18639 0.00645161290322581 0.529742788119937 0.851509813975273 0.935192675003877 GO:0140658 ATP-dependent chromatin remodeler activity 1/227 158/18639 0.00632911392405063 0.519684380750572 0.856913967408732 0.939508084749333 GO:0003689 DNA clamp loader activity 1/227 160/18639 0.00625 0.513188325991189 0.860407492661748 0.940102183234191 GO:0015079 potassium ion transmembrane transporter activity 1/227 160/18639 0.00625 0.513188325991189 0.860407492661748 0.940102183234191 GO:0140713 histone chaperone activity 1/227 164/18639 0.00609756097560976 0.50067153755238 0.86714180966687 0.94583789855787 GO:0015103 inorganic anion transmembrane transporter activity 1/227 165/18639 0.00606060606060606 0.497637164597517 0.868774221531856 0.945998596779132 GO:0005244 voltage-gated monoatomic ion channel activity 1/227 173/18639 0.00578034682080925 0.474625041379135 0.881134662184332 0.957709099309835 GO:0004721 phosphoprotein phosphatase activity 1/227 175/18639 0.00571428571428571 0.469200755191945 0.884039168593694 0.957709099309835 GO:0022832 voltage-gated channel activity 1/227 175/18639 0.00571428571428571 0.469200755191945 0.884039168593694 0.957709099309835 GO:0043021 ribonucleoprotein complex binding 1/227 177/18639 0.00564971751412429 0.463899051743448 0.886873007645055 0.959147887724788 GO:0016853 isomerase activity 1/227 180/18639 0.00555555555555556 0.456167400881057 0.89099499845703 0.961972566130726 GO:0008234 cysteine-type peptidase activity 1/227 187/18639 0.0053475935828877 0.439091615821339 0.900040685558285 0.968955901442251 GO:0140597 protein carrier chaperone 1/227 188/18639 0.00531914893617021 0.436756022120161 0.901270403983294 0.968955901442251 GO:0022836 gated channel activity 2/227 318/18639 0.00628930817610063 0.516415925525725 0.902026451421122 0.968955901442251 GO:0016758 hexosyltransferase activity 1/227 197/18639 0.0050761421319797 0.416802701312641 0.911681642665332 0.971969697389919 GO:0005216 monoatomic ion channel activity 3/227 448/18639 0.00669642857142857 0.54984463499056 0.91284042352398 0.971969697389919 GO:0003714 transcription corepressor activity 1/227 204/18639 0.00490196078431373 0.402500647836227 0.919017174805769 0.971969697389919 GO:0008094 ATP-dependent activity, acting on DNA 1/227 210/18639 0.00476190476190476 0.391000629326621 0.924819859347648 0.971969697389919 GO:0061630 ubiquitin protein ligase activity 2/227 353/18639 0.0056657223796034 0.465213213363118 0.931017770708821 0.971969697389919 GO:0106310 protein serine kinase activity 2/227 361/18639 0.00554016620498615 0.454903779271968 0.936401756720646 0.971969697389919 GO:0000287 magnesium ion binding 1/227 230/18639 0.00434782608695652 0.357000574602567 0.941332976533216 0.971969697389919 GO:0061659 ubiquitin-like protein ligase activity 2/227 372/18639 0.00537634408602151 0.441452323433281 0.943159672505034 0.971969697389919 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 1/227 243/18639 0.00411522633744856 0.337901778430413 0.950074779197198 0.971969697389919 GO:0004676 3-phosphoinositide-dependent protein kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0004711 ribosomal protein S6 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0035175 histone H3S10 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0035979 histone H2AXS139 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0044022 histone H3S28 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0044023 histone H4S1 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0044024 histone H2AS1 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0044025 histone H2BS14 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0072354 histone H3T3 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0072371 histone H2AS121 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0072518 Rho-dependent protein serine/threonine kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0140823 histone H2BS36 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0140855 histone H3S57 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0140995 histone H2A kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0140997 histone H4 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0140998 histone H2B kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:1990244 histone H2AT120 kinase activity 1/227 245/18639 0.00408163265306122 0.335143396565675 0.951299328734893 0.971969697389919 GO:0004677 DNA-dependent protein kinase activity 1/227 246/18639 0.0040650406504065 0.33378102503492 0.951900342781711 0.971969697389919 GO:0140857 histone H3T45 kinase activity 1/227 246/18639 0.0040650406504065 0.33378102503492 0.951900342781711 0.971969697389919 GO:0035402 histone H3T11 kinase activity 1/227 247/18639 0.00404858299595142 0.332429684852592 0.952493971998726 0.971969697389919 GO:0035403 histone H3T6 kinase activity 1/227 247/18639 0.00404858299595142 0.332429684852592 0.952493971998726 0.971969697389919 GO:0004679 AMP-activated protein kinase activity 1/227 248/18639 0.00403225806451613 0.331089242574961 0.953080306728841 0.971969697389919 GO:0140104 molecular carrier activity 1/227 249/18639 0.00401606425702811 0.329759566901969 0.953659436214598 0.971969697389919 GO:0003713 transcription coactivator activity 1/227 256/18639 0.00390625 0.320742703744493 0.957518867160344 0.97434427856412 GO:0003730 mRNA 3'-UTR binding 1/227 262/18639 0.00381679389312977 0.313397450986986 0.960571125595552 0.975891239241415 GO:0016757 glycosyltransferase activity 1/227 267/18639 0.00374531835205993 0.307528584863634 0.962947160668114 0.976747358830555 GO:0008017 microtubule binding 1/227 276/18639 0.0036231884057971 0.297500478835472 0.96687044016916 0.979167679471788 GO:0004842 ubiquitin-protein transferase activity 2/227 449/18639 0.0044543429844098 0.365746691129578 0.974556049317044 0.985384449865011 GO:0019787 ubiquitin-like protein transferase activity 2/227 479/18639 0.00417536534446764 0.342839800244636 0.981530482349366 0.98772195949979 GO:0030371 translation repressor activity 1/227 329/18639 0.00303951367781155 0.249574869782949 0.982880375838571 0.98772195949979 GO:0140097 catalytic activity, acting on DNA 1/227 336/18639 0.00297619047619048 0.244375393329138 0.984312167711643 0.98772195949979 GO:0003712 transcription coregulator activity 2/227 495/18639 0.00404040404040404 0.331758109731678 0.984453781265384 0.98772195949979 GO:0016755 aminoacyltransferase activity 2/227 496/18639 0.00403225806451613 0.331089242574961 0.984620791652067 0.98772195949979 GO:0045182 translation regulator activity 1/227 356/18639 0.00280898876404494 0.230646438647726 0.987778983223426 0.989332094832268 GO:0140098 catalytic activity, acting on RNA 1/227 387/18639 0.00258397932816537 0.212170884130724 0.991705981297931 0.991705981297931