category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	47/316	233/9376	5.9851143586679	COL4A1/COL4A2/COL6A1/ITGB1/TPM4/COL6A2/SYNE2/ACTB/TNNT1/FN1/FBLN1/DSP/MYH10/LMOD1/LAMA2/COL3A1/ANK2/TLN1/TPM1/ITGA1/SPTAN1/PDLIM5/VCL/SPTBN1/MYH9/CSRP1/FBLN2/DMD/TNNI3/NID1/FBN1/TPM2/ACTG1/DAG1/COL1A2/PDLIM7/FBN2/COL1A1/ATP1A1/SDC2/FHL1/FMNL2/COL5A3/THBS1/MYL9/PLEC/JUP	14.3904311769297
NA	NA	hsa04518	Integrin signaling	34/316	154/9376	6.55071510767713	COL4A1/COL4A2/COL6A1/ITGB1/PIK3R1/COL6A2/CCND2/ACTB/FN1/FREM1/FLNA/LAMC1/ACTN4/LAMA2/PDGFRB/TLN1/ITGA1/VCL/LAMA4/FLNB/IGF1R/FBN1/ACTG1/LIMS2/COL1A2/PDGFRA/COL1A1/ARHGEF6/THBS1/LAMB1/AKT2/PIK3CA/FERMT2/FLT1	12.9706523669086
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	35/316	203/9376	5.11567001309472	COL4A1/COL4A2/COL6A1/ITGB1/PIK3R1/COL6A2/CCND2/ACTB/FN1/FLNA/LAMC1/ACTN4/LAMA2/PDGFRB/TLN1/ITGA1/VCL/LAMA4/FLNB/IGF1R/CAPN2/ACTG1/COL1A2/PDGFRA/PTEN/BCL2/COL1A1/THBS1/MYL9/LAMB1/ROCK1/DOCK1/AKT2/PIK3CA/FLT1	11.0712829296093
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/316	204/9376	4.07247455944403	PLCG2/GPC3/ITGB1/PIK3R1/ACTB/FN1/FLNA/WNT2/MMP2/ANK2/IGF2/IQGAP1/IGF1R/ACTG1/COL1A2/TGFB2/COL1A1/SDC2/FGFR1/THBS1/EIF4B/ITPR2/ROCK1/MSN/HIF1A/AKT2/PIK3CA/TIMP3	8.28583797973119
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	37/316	362/9376	3.03265962654731	COL4A1/COL4A2/COL6A1/ITGB1/PIK3R1/COL6A2/CCND2/IRS1/FN1/LAMC1/PRLR/LAMA2/PDGFRB/IGF2/ITGA1/LAMA4/BCL2L1/IGF1R/YWHAE/COL1A2/PDGFRA/PTEN/BCL2/COL1A1/FGFR1/BCL2L11/MAGI1/THBS1/EIF4B/LAMB1/PPP2CB/YWHAZ/CDKN1B/AKT2/PIK3CA/CREB3L1/FLT1	7.36589036056928
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/316	101/9376	5.28788068680286	PLCG2/COL4A1/COL4A2/PIK3R1/FN1/MMP2/COL3A1/COL1A2/TGFB2/BCL2/TGFBR1/COL1A1/TGFB3/CDKN1B/AKT2/PIK3CA/F3/THBD	8.09117325465389
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/316	89/9376	5.33409187882236	COL4A1/COL4A2/COL6A1/ITGB1/COL6A2/FN1/FREM1/LAMC1/LAMA2/ITGA1/LAMA4/DAG1/COL1A2/COL1A1/THBS1/LAMB1	7.67220988212547
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/316	103/9376	4.89713653680718	COL4A1/COL4A2/PIK3R1/FN1/LAMC1/ACTN4/LAMA2/COL3A1/VCL/LAMA4/IL1R1/COL1A2/TGFB2/COL1A1/TGFB3/LAMB1/PIK3CA	7.42709851871972
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/316	93/9376	5.10466857220634	COL4A1/COL4A2/ITGB1/PIK3R1/FN1/LAMC1/LAMA2/LAMA4/BCL2L1/PTEN/BCL2/LAMB1/CDKN1B/AKT2/PIK3CA/SKP2	7.42917307141298
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	32/316	333/9376	2.85125631961075	COL4A1/COL4A2/COL6A1/ITGB1/PIK3R1/COL6A2/CCND2/FN1/LAMC1/WNT2/LAMA2/PDGFRB/ITGA1/LAMA4/JAG1/COL1A2/MAML2/PTEN/COL1A1/MAGI1/THBS1/LAMB1/PPP2CB/DLG3/MAML3/CDKN1B/AKT2/PIK3CA/CREB3L1/IRF3/LLGL2/CREBBP	6.4238809834173
NA	NA	hsa04517	IgSF CAM signaling	30/316	299/9376	2.97701198086448	PLCG2/ITGB1/PIK3R1/CADM3/ACTB/NRP1/TJP1/MYH10/ACTN4/ANK2/EPB41L2/SPTAN1/NFASC/VCL/SPTBN1/MYH9/IQGAP1/ACTG1/FGFR1/MAGI1/MYL9/ARPC5/MSN/PMP22/AKT2/CNTNAP2/PIK3CA/LYN/NRP2/MBP	6.48841781863879
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/316	253/9376	3.04918196827938	PLCG2/ITGB1/PIK3R1/ACTB/ACTN4/TLN1/VCL/CBX3/CAST/BCL2L1/CAPN2/ACTG1/IL1R1/RIPK1/BCL2/MYL9/ITPR2/TIFA/ARPC5/WIPI2/ROCK1/DOCK1/FBXW11/AKT2/PIK3CA/IRF3	6.17073689388755
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	24/316	232/9376	3.06940200785683	ITGB1/PIK3R1/ACTB/FN1/CFL2/IQGAP2/MYH10/ACTN4/PDGFRB/ITGA1/VCL/MYH9/IQGAP1/ACTG1/PDGFRA/FGFR1/ARHGEF6/MYL9/ARPC5/ROCK1/MSN/DOCK1/AKT2/PIK3CA	5.96054307110284
Organismal Systems	Immune system	hsa04611	Platelet activation	16/316	126/9376	3.76773156519992	PLCG2/ITGB1/PIK3R1/ACTB/COL3A1/TLN1/PRKG1/ACTG1/COL1A2/SNAP23/COL1A1/ITPR2/ROCK1/AKT2/PIK3CA/LYN	5.84121852186203
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	21/316	205/9376	3.03945662241433	MT-ND3/MT-ATP8/PIK3R1/IRS1/MT-ND4L/CYBA/MMP2/COL3A1/MT-CO2/TNNI3/MT-ND6/COL1A2/TGFB2/PTEN/TGFBR1/COL1A1/TGFB3/AKT2/MT-ND5/PIK3CA/MT-CYB	5.51376353826304
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	18/316	170/9376	3.14162323157111	ITGB1/ACTB/TJP1/MYH10/ACTN4/CFTR/CGNL1/MYH9/ACTG1/MAGI1/AMOTL1/MYL9/ARPC5/PPP2CB/DLG3/ROCK1/MSN/LLGL2	5.26256078723244
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	18/316	170/9376	3.14162323157111	PLCG2/PIK3R1/ACTB/WNT2/IGF2/BCL2L1/IGF1R/ACTG1/TGFB2/PTEN/TGFBR1/SMARCD3/GSTT2B/TGFB3/AKT2/PIK3CA/SMARCC1/SMARCC2	5.26256078723244
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/316	112/9376	3.70886075949367	ITGB1/LAMC1/LAMA2/LAMA4/HLA-DRA/BCL2L1/IFNGR2/TGFB2/BCL2/TGFB3/LAMB1/AKT2/HLA-DRB1/HLA-DPA1	5.38593987426768
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/316	99/9376	3.8961769594681	ITGB1/TPM4/ACTB/LAMA2/TPM1/ITGA1/DMD/TNNI3/TPM2/ACTG1/DAG1/TGFB2/TGFB3	5.41008382060268
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/316	103/9376	3.74486911638196	COL4A1/COL4A2/COL6A1/COL6A2/COL21A1/COL3A1/COL15A1/COL8A2/COL1A2/COL1A1/ATP1A1/COL5A3/DPP4	5.23112627843981
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/316	105/9376	3.67353827606992	ITGB1/TPM4/ACTB/LAMA2/TPM1/ITGA1/DMD/TNNI3/TPM2/ACTG1/DAG1/TGFB2/TGFB3	5.1449699884124
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/316	168/9376	3.00241109101869	IL6ST/PIK3R1/CCND2/PRLR/SOCS2/LIFR/PDGFRB/CISH/BCL2L1/IFNGR2/STAT6/PDGFRA/BCL2/FHL1/AKT2/PIK3CA/CREBBP	4.89091717465163
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/316	93/9376	3.82850142915476	ACTB/TJP1/ACTN4/VCL/IQGAP1/IGF1R/ACTG1/TGFBR1/FGFR1/MYL9/ROCK1/CREBBP	5.11939667728995
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	20/316	224/9376	2.64918625678119	PIK3R1/CCND2/NRP1/TLN1/ETS1/HLA-DRA/BCL2L1/IL1R1/TGFB2/PTEN/TGFBR1/TGFB3/AKT2/HLA-DRB1/PIK3CA/CREB3L1/LTBR/TRRAP/CREBBP/HLA-DPA1	4.66552790290883
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/316	80/9376	4.07974683544304	PLCG2/PIK3R1/PDGFRB/BCL2L1/IGF1R/PDGFRA/PTEN/BCL2/BCL2L11/AKT2/PIK3CA	5.166269223466
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/316	110/9376	3.50655926352129	PLCG2/PIK3R1/IFNGR2/IGF1R/BCL2/EPAS1/HIF1A/CDKN1B/AKT2/PIK3CA/LTBR/CREBBP/FLT1	4.93847946878357
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/316	71/9376	4.17899803886611	PIK3R1/PDGFRB/GLS/PDGFRA/PTEN/FGFR1/IDH1/HIF1A/AKT2/PIK3CA	5.02141743642849
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/316	116/9376	3.32518550851157	PLCG2/ITGB1/PIK3R1/ACTB/ACTN4/CYBA/MMP2/VCL/ACTG1/MYL9/ROCK1/MSN/PIK3CA	4.70593787455415
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/316	133/9376	3.12325116588941	PIK3R1/CCND2/IRS1/IGF1R/TGFB2/PTEN/TGFBR1/BCL2L11/TGFB3/CDKN1B/AKT2/PIK3CA/CREBBP/SKP2	4.60559553983388
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/316	106/9376	3.35896823501314	PIK3R1/PDGFRB/IGF1R/PDGFRA/PTEN/BCL2/FGFR1/CDKN1B/AKT2/PIK3CA/CREB3L1/CREBBP	4.56142185558722
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/316	78/9376	3.80395975332684	ITGB1/PIK3R1/ACTB/FN1/VCL/ACTG1/ARPC5/CLTC/DOCK1/PIK3CA	4.64396979942479
Cellular Processes	Cell motility	hsa04814	Motor proteins	17/316	194/9376	2.60002609943886	TPM4/ACTB/TNNT1/MYH10/TPM1/MYO10/MYH9/MYO1E/TNNI3/TPM2/ACTG1/DYNC1I2/MYO18A/DNAH10/MYL9/DCTN1/KIF1B	4.20556518013217
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/316	110/9376	3.23682393555811	FST/PITX2/LTBP1/FBN1/TGFB2/TGFBR1/ID4/THBS1/TGFB3/PPP2CB/ROCK1/CREBBP	4.40704085548687
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/316	98/9376	3.3304055799535	PLCG2/PIK3R1/MARCKS/CFL2/ASAP1/MYO10/ARPC5/DOCK1/AKT2/PIK3CA/LYN	4.33094278015964
NA	NA	hsa04519	Cadherin signaling	27/316	404/9376	1.98295525755107	ACTB/GJA1/PCDH10/WNT2/DSP/TJP1/ACTN4/KRT18/PDGFRB/VCL/CDH11/YAP1/MYO1E/IGF1R/YWHAE/ACTG1/LIMA1/PDGFRA/FGFR1/AMOTL1/ARPC5/ROCK1/YWHAZ/RERE/JUP/ADAM10/CREBBP	3.77176721061415
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/316	70/9376	3.81482820976492	PIK3R1/ETS1/TGFB2/EPAS1/TGFB3/HIF1A/AKT2/PIK3CA/CREBBP	4.41452998850705
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	17/316	205/9376	2.46051250385922	PLCG2/PIK3R1/CCND2/HLA-DRA/RIPK1/BCL2/BCL2L11/CD58/NCOR2/CDKN1B/AKT2/HLA-DRB1/PIK3CA/IRF3/LYN/HLA-DPA1/SKP2	3.94856183870344
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/316	323/9376	2.11278755339578	PLCG2/PIK3R1/CCND2/IRS1/MARCKS/FSCN1/PDGFRB/TPM1/ZEB2/GLS/IGF2BP1/TGFB2/PDGFRA/PTEN/BCL2/BCL2L11/THBS1/ROCK1/CDKN1B/DNMT3A/PIK3CA/CREBBP/TIMP3	3.80086409456778
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/316	86/9376	3.45010303208714	ITGB1/ACTB/GJA1/DSP/LAMA2/ITGA1/DMD/ACTG1/DAG1/JUP	4.26275916742224
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/316	157/9376	2.64581149721841	PIK3R1/CCND2/HIPK3/ETS1/CAPN2/TGFB2/PTEN/TGFBR1/TGFB3/ITPR2/RBBP4/FBXW11/AKT2/PIK3CA	3.88376632033724
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/316	157/9376	2.64581149721841	CCND2/ACTB/WNT2/YAP1/YWHAE/ACTG1/TGFB2/TGFBR1/TGFB3/PPP2CB/DLG3/YWHAZ/FBXW11/LLGL2	3.88376632033724
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/316	142/9376	2.71634872526297	PIK3R1/ACTB/CYBA/MMP2/MAP2K5/ACTG1/IL1R1/BCL2/SDC2/GSTT2B/AKT2/PIK3CA/THBD	3.84875130847696
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/316	169/9376	2.45794322522657	PIK3R1/IRS1/BCL2L1/IGF1R/DAPK1/PTEN/BCL2/WIPI2/PPP2CB/NBR1/SH3GLB1/HIF1A/AKT2/PIK3CA	3.57182336236676
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/316	117/9376	2.78957048577302	ACTB/ACTG1/SMARCA1/YY1/SMARCD3/RBBP4/GATAD2A/MORF4L1/SMARCC1/SMARCC2/TRRAP	3.63768239372945
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/316	17/9376	6.98138495904691	MYH10/MYH9/DAG1/NRP2	4.6097414982052
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/316	137/9376	2.59890972928024	PIK3R1/ACTB/SPTAN1/BCL2L1/CAPN2/ACTG1/RIPK1/BCL2/BCL2L11/ITPR2/AKT2/PIK3CA	3.5207632783619
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/316	70/9376	3.39095840867993	ACTB/LAMA2/DMD/HLA-DRA/ACTG1/DAG1/HLA-DRB1/HLA-DPA1	3.74976972298858
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/316	103/9376	2.88066855106305	PIK3R1/C1QA/IFNGR2/TGFB2/TGFBR1/TGFB3/C1QB/PPP2CB/AKT2/PIK3CA	3.58414709822988
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/316	87/9376	3.06940200785683	PIK3R1/TGFB2/BCL2/TGFBR1/BCL2L11/TGFB3/AKT2/PIK3CA/MSH3	3.62147166594087
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/316	73/9376	3.2516039535287	PIK3R1/PDGFRB/IGF1R/PDGFRA/PTEN/FGFR1/AKT2/PIK3CA	3.60667494439229
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/316	75/9376	3.16489451476793	PIK3R1/BCL2L1/BCL2/GSTT2B/TOP2B/AKT2/PIK3CA/MSH3	3.51534238250733
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/316	109/9376	2.72209963999535	IL6ST/HLA-DRA/IFNGR2/STAT6/IL1R1/TGFBR1/HIF1A/AHR/HLA-DRB1/HLA-DPA1	3.37727965720363
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/316	76/9376	3.12325116588941	PLCG2/PIK3R1/PDGFRB/IGF1R/PDGFRA/PTEN/AKT2/PIK3CA	3.47081746203238
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/316	77/9376	3.0826894624363	PIK3R1/BCL2L1/TGFB2/TGFBR1/ARHGEF6/TGFB3/AKT2/PIK3CA	3.42702157910171
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/316	77/9376	3.0826894624363	PIK3R1/BCL2L1/TGFB2/TGFBR1/TGFB3/CDKN1B/AKT2/PIK3CA	3.42702157910171
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/316	130/9376	2.51061343719572	COL4A1/COL4A2/PIK3R1/MMP2/COL3A1/COL1A2/TGFBR1/COL1A1/AKT2/PIK3CA/CREB3L1	3.23901646578007
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/316	78/9376	3.04316780266147	ITGB1/CYBA/HLA-DRA/IFNGR2/TGFB2/TGFB3/HLA-DRB1/HLA-DPA1	3.38393215503867
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/316	50/9376	3.56050632911392	TGFB2/SDC2/LRP1/THBS1/TGFB3/ACKR1	3.39022272718605
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/316	66/9376	3.14691215957039	HLA-DRA/IFNGR2/STAT6/TGFB2/TGFB3/HLA-DRB1/HLA-DPA1	3.26871069253261
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/316	138/9376	2.36507062924234	ITGB1/PIK3R1/ACTB/FN1/ACTG1/ARPC5/ROCK1/DOCK1/AKT2/PIK3CA/IRF3	3.01696844214482
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/316	158/9376	2.25348501842653	CDKN1C/CCND2/YWHAE/TGFB2/RAD21/TGFB3/WEE1/PPP2CB/YWHAZ/CDKN1B/CREBBP/SKP2	2.96752522924877
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/316	122/9376	2.43203984229093	PLCG2/PIK3R1/ACTB/ACTG1/ATP1A1/NCOA1/HIF1A/AKT2/PIK3CA/CREBBP	2.97327685059785
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/316	122/9376	2.43203984229093	PLCG2/PIK3R1/IRS1/SOCS2/SSTR1/ITPR2/AKT2/PIK3CA/CREB3L1/CREBBP	2.97327685059785
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/316	142/9376	2.29844892137636	PLCG2/PIK3R1/JUND/CYBA/IFNGR2/IL1R1/TGFB2/TGFBR1/ITPR2/AKT2/PIK3CA	2.91165012772803
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/316	163/9376	2.18435971111284	PIK3R1/STAT6/TGFB2/BCL2/TGFBR1/TGFB3/YWHAZ/AKT2/PIK3CA/CREB3L1/IRF3/CREBBP	2.84866888968679
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	14/316	205/9376	2.02630441494288	IL6ST/PIK3R1/CCND2/ACTN4/YWHAE/YWHAZ/CDKN1B/PIK3CA/CREB3L1/IRF3/LTBR/LYN/CREBBP/SKP2	2.77466056403373
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/316	71/9376	2.92529862720628	PIK3R1/CCND2/PRLR/SOCS2/CISH/AKT2/PIK3CA	3.04112427210988
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/316	227/9376	1.96063123849886	MT-ND3/MT-ATP8/PIK3R1/MT-ND4L/CYBA/MT-CO2/MT-ND6/PTEN/GSTT2B/HIF1A/AHR/AKT2/MT-ND5/PIK3CA/MT-CYB	2.73620039152084
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/316	166/9376	2.14488333079152	IRS1/PDE3A/KCNMA1/PRKG1/KCNJ8/ATP1A1/GTF2I/MYL9/ITPR2/ROCK1/AKT2/CREB3L1	2.77939672722197
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/316	212/9376	1.959398137091	ITGB1/PIK3R1/ACTB/PDGFRB/TLN1/IGF1R/ACTG1/PDGFRA/FGFR1/MAGI1/THBS1/AKT2/PIK3CA/FLT1	2.63869589668889
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/316	93/9376	2.55233428610317	JAG1/HLA-DRA/IFNGR2/STAT6/MAML2/MAML3/HLA-DRB1/HLA-DPA1	2.80962028316693
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/316	235/9376	1.89388634527336	MT-ND3/MT-ATP8/ACTB/MT-ND4L/MT-CO2/PRKG1/ACTG1/MT-ND6/SMARCD3/FGFR1/MT-ND5/CREB3L1/SMARCC1/SMARCC2/MT-CYB	2.59169839944822
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/316	173/9376	2.05809614399649	PIK3R1/ACTB/HLA-DRA/IFNGR2/ACTG1/AKT2/HLA-DRB1/PIK3CA/IRF3/CREBBP/HLA-DPA1/ADAR	2.62330358598412
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/316	136/9376	2.18168279970216	PIK3R1/CCND2/BCL2L1/BCL2/MSN/CDKN1B/AKT2/PIK3CA/IRF3/ADAR	2.59238478181714
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/316	62/9376	2.87137607186607	PIK3R1/IRS1/IGF1R/AKT2/EIF4EBP2/PIK3CA	2.76092036853704
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/316	99/9376	2.39764735967268	PIK3R1/MMP2/JAG1/IGF1R/BCL2/CDKN1B/AKT2/PIK3CA	2.61081745808167
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/316	201/9376	1.91901253227533	CCND2/PROM1/BCL2L1/IGF1R/CDK14/CCNT2/KLF3/CDKN1B/JUP/RUNX1T1/TAF15/FLT1/HOXA10	2.45969640666612
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/316	120/9376	2.2253164556962	PLCG2/PIK3R1/IRS1/MAP2K5/YWHAE/BCL2/SORT1/AKT2/PIK3CA	2.52285503713897
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/316	248/9376	1.79461004491629	ACTB/FLNA/AHNAK/S100A10/ACTG1/RIPK1/DYNC1I2/BCL2/PIK3C2A/MYL9/ARPC5/DCTN1/AKT2/PIK3CA/GSDMD	2.36841147285127
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/316	184/9376	1.93505778756192	PLCG2/ITGB1/PIK3R1/CFL2/NRP1/EFNB2/SEMA3C/SEMA6D/PLXNB2/MYL9/ROCK1/PIK3CA	2.39225480683163
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/316	144/9376	2.06047819971871	IL6ST/PIK3R1/WNT2/LIFR/IGF1R/ID4/FGFR1/REST/AKT2/PIK3CA	2.3949705307844
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/316	87/9376	2.38731267277754	TPM4/TPM1/MT-CO2/TNNI3/TPM2/ATP1A1/MT-CYB	2.4278093464632
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/316	51/9376	2.90891039960288	PLCG2/ACTB/TJP1/CFTR/ACTG1	2.55276767839768
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	13/316	214/9376	1.80243700461375	PLCG2/PIK3R1/CFL2/SAMHD1/BCL2L1/RIPK1/BCL2/ITPR2/WEE1/FBXW11/AKT2/PIK3CA/IRF3	2.2176232782373
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	10/316	150/9376	1.97805907172996	PIK3R1/WNT2/TGFB2/BCL2/TGFBR1/TGFB3/CDKN1B/AKT2/JUP/PIK3CA	2.25511695747903
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/316	89/9376	2.33366519698478	GJA1/TJP1/PDGFRB/MAP2K5/PRKG1/PDGFRA/ITPR2	2.36085426655369
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	17/316	308/9376	1.63767877691928	MT-ND3/MT-ATP8/MT-ND4L/MT-CO2/MT-ND6/DNAH10/AP2A2/AP2A1/WIPI2/CLTC/DCTN1/REST/POLR2L/MT-ND5/CREB3L1/MT-CYB/CREBBP	2.12513559868536
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/316	90/9376	2.30773558368495	PIK3R1/IRS1/SESN1/IGF1R/AKT2/PIK3CA/CREB3L1	2.3280480344769
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/316	90/9376	2.30773558368495	PIK3R1/EML4/IFNGR2/PTEN/HIF1A/AKT2/PIK3CA	2.3280480344769
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/316	93/9376	2.23329250034028	KCNMA1/CST3/PRKG1/ATP1A1/ITPR2/SLC4A2/VAMP2	2.23217618463617
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/316	200/9376	1.78025316455696	ITGB1/ACTB/TJP1/MYH10/MYO10/MYH9/MYO1E/ACTG1/IL1R1/RIPK1/ARPC5/ROCK1	2.08299829666853
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/316	38/9376	3.12325116588941	PIK3R1/IRS1/ATP1A1/PIK3CA	2.44923984134831
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/316	157/9376	1.88986535515601	C1QA/XKR4/ANO6/LRP1/THBS1/C1QB/HIF1A/DOCK1/DNMT3A/ADAM10	2.09989364020782
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/316	75/9376	2.37367088607595	CCND2/SESN1/BCL2L1/PTEN/BCL2/THBS1	2.23055832628262
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/316	180/9376	1.81322081575246	PIK3R1/CD74/HLA-DRA/BCL2L1/IFNGR2/BCL2/AKT2/HLA-DRB1/PIK3CA/IRF3/HLA-DPA1	2.05736022109466
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/316	76/9376	2.34243837441706	ACTB/CFTR/ACTG1/ATP1A1/ITPR2/SLC4A2	2.19444530467375
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/316	139/9376	1.92113650851471	PIK3R1/KRT18/MMP2/BCL2/NCOA1/ITPR2/AKT2/PIK3CA/CREB3L1	2.04329468136686
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	15/316	275/9376	1.61841196777906	MT-ND3/MT-ATP8/PIK3R1/LAMC1/MT-ND4L/CYBA/MT-CO2/C1QA/MT-ND6/ITPR2/C1QB/MT-ND5/PIK3CA/CREB3L1/MT-CYB	1.94385898369354
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/316	78/9376	2.28237585199611	ITGB1/CFL2/C1QA/C1QB/SERPING1/IRF3	2.12389451065255
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/316	59/9376	2.51448187084317	PIK3R1/IRS1/PRKG1/AKT2/PIK3CA	2.17930049606322
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/316	60/9376	2.47257383966245	PRKG1/IGF1R/ITPR2/PPP2CB/LYN	2.13699274069485
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/316	122/9376	1.94563187383275	PIK3R1/IRS1/CFTR/IGF1R/PPP2CB/AKT2/PIK3CA/CREB3L1	1.96337090395224
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/316	61/9376	2.43203984229093	MT1E/SLC40A1/MT2A/ATP1A1/SLC30A1	2.09552897229063
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/316	62/9376	2.39281339322172	JAG1/MAML2/NCOR2/MAML3/CREBBP	2.05487658238705
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/316	238/9376	1.62067865120732	PLCG2/PIK3R1/PDGFRB/IGF2/ETS1/BCL2L1/IGF1R/PDGFRA/FGFR1/RASAL2/AKT2/PIK3CA/FLT1	1.81131836322229
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/316	44/9376	2.69735327963176	DYNC1I2/DCTN1/VAMP2/CREB3L1	2.10754228888149
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/316	83/9376	2.14488333079152	SAMHD1/RIPK1/POLR2L/IRF3/GSDMD/ADAR	1.9565339601553
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/316	148/9376	1.80431063975368	PIK3R1/WNT2/JAG1/IGF1R/PTEN/FGFR1/NCOA1/AKT2/PIK3CA	1.8418996239124
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/316	105/9376	1.97805907172996	PLCG2/BCL2L1/IL1R1/RIPK1/BCL2/LTBR/LYN	1.8821816077914
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/316	47/9376	2.52518179369782	PIK3R1/IRS1/SOCS2/PIK3CA	1.95757349204224
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/316	154/9376	1.73401282262042	TPM4/TPM1/TNNI3/TPM2/BCL2/ATP1A1/PPP2CB/AKT2/CREB3L1	1.71520695448681
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/316	88/9376	2.02301495972382	C1QA/A2M/C1QB/SERPING1/F3/THBD	1.80064167681117
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/316	48/9376	2.47257383966245	PIK3R1/ATP1A1/AKT2/PIK3CA	1.91015456892006
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/316	155/9376	1.72282564311964	ITGB1/ACTB/CYBA/HLA-DRA/ACTG1/DYNC1I2/THBS1/HLA-DRB1/HLA-DPA1	1.69463226156756
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/316	68/9376	2.18168279970216	PIK3R1/AKT2/JUP/PIK3CA/RUNX1T1	1.82638471463185
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	12/316	226/9376	1.57544527836899	PIK3R1/PDE3A/SSTR1/CFTR/TNNI3/ATP1A1/MYL9/ROCK1/AKT2/PIK3CA/CREB3L1/CREBBP	1.63535779044188
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/316	300/9376	1.48354430379747	FLNA/JUND/PDGFRB/MAP2K5/IGF2/IGF1R/MAP4K4/IL1R1/TGFB2/PDGFRA/TGFBR1/FGFR1/TGFB3/AKT2/FLT1	1.58969839604645
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/316	69/9376	2.15006420840213	PLCG2/PIK3R1/AKT2/PIK3CA/LYN	1.79063412538622
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/316	134/9376	1.77139618363877	MYH10/KCNMA1/MYH9/PRKG1/CALD1/MYL9/ITPR2/ROCK1	1.67962366000033
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/316	181/9376	1.63927547380936	CD74/HLA-DRA/IFNGR2/TGFB2/BCL2/TGFB3/AKT2/HLA-DRB1/CREBBP/HLA-DPA1	1.6218718800942
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/316	158/9376	1.6901137638199	PIK3R1/IRS1/WNT2/IGF1R/PTEN/EIF4B/AKT2/PIK3CA/SKP2	1.63378897639965
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/316	50/9376	2.37367088607595	HLA-DRA/HLA-DRB1/LTBR/HLA-DPA1	1.81880052577729
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/316	160/9376	1.66898734177215	ITGB1/CADM3/NFASC/HLA-DRA/SDC2/CD58/CNTNAP2/HLA-DRB1/HLA-DPA1	1.59393915551057
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/316	32/9376	2.78164556962025	BCL2L1/BCL2/BCL2L11	1.88536294496325
Human Diseases	Immune disease	hsa05310	Asthma	3/316	32/9376	2.78164556962025	HLA-DRA/HLA-DRB1/HLA-DPA1	1.88536294496325
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/316	138/9376	1.7200513667217	MT-ND3/MT-ATP8/MT-ND4L/MT-CO2/PPA1/MT-ND6/MT-ND5/MT-CYB	1.5913991580995
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/316	73/9376	2.03225247095544	PLCG2/PIK3R1/EML4/AKT2/PIK3CA	1.65348755825701
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/316	95/9376	1.87395069953364	HLA-DRA/TGFB2/TGFB3/HLA-DRB1/HLA-DPA1/FLT1	1.59888206622062
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/316	53/9376	2.23931215667542	ATP1A1/AP2A2/AP2A1/CLTC	1.68968552319583
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	18/316	388/9376	1.37648440558528	MT-ND3/MT-ATP8/PIK3R1/IRS1/WNT2/MT-ND4L/MT-CO2/CAPN2/MT-ND6/LRP1/LPL/ITPR2/WIPI2/AKT2/MT-ND5/ADAM10/PIK3CA/MT-CYB	1.41447867242256
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/316	98/9376	1.81658486179282	PLCG2/PIK3R1/PTEN/PIK3C2A/ITPR2/PIK3CA	1.51758232214662
NA	NA	hsa04382	Cornified envelope formation	11/316	217/9376	1.50405413288223	COL4A1/COL4A2/DSP/TJP1/KRT18/S100A10/DST/PPP2CB/S100A8/PLEC/JUP	1.40296907468048
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/316	99/9376	1.79823551975451	KRT18/C1QA/HLA-DRA/C1QB/HLA-DRB1/HLA-DPA1	1.49111091307326
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/316	99/9376	1.79823551975451	PIK3R1/PDGFRB/PDGFRA/HIF1A/AKT2/PIK3CA	1.49111091307326
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/316	56/9376	2.11934900542495	CCND2/CDON/BCL2/FBXW11	1.56897728360721
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/316	36/9376	2.47257383966245	GALNT15/GALNT1/GALNT7	1.65317935781527
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/316	196/9376	1.51382071816068	PLCG2/IL6ST/PIK3R1/ITPR2/HIF1A/AKT2/PIK3CA/IRF3/LYN/CREBBP	1.35763613143091
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/316	79/9376	1.87790418202211	SLC6A2/AP2A2/AP2A1/CLTC/VAMP2	1.46337061059352
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/316	125/9376	1.66156962025316	PIK3R1/PTEN/BCL2/PPP2CB/ROCK1/AKT2/PIK3CA	1.39059703990022
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/316	59/9376	2.01158549667453	PIK3R1/PTEN/AKT2/PIK3CA	1.45564553604449
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/316	105/9376	1.69547920433996	BCL2L1/BNIP3L/CITED2/NBR1/HIF1A/AMFR	1.33838354435456
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/316	39/9376	2.28237585199611	HLA-DRA/HLA-DRB1/HLA-DPA1	1.49868042959815
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/316	60/9376	1.97805907172996	PLCG2/PIK3R1/AKT2/PIK3CA	1.41935506387698
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	11/316	227/9376	1.43779624156583	PIK3R1/AKAP13/IL1R1/RIPK1/PDGFRA/ITPR2/ROCK1/AKT2/PIK3CA/CREB3L1/IRF3	1.24699072814942
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/316	83/9376	1.7874027756596	CBX3/AUTS2/YY1/RBBP4/CREBBP	1.34562206424428
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/316	156/9376	1.52158390133074	PIK3R1/YWHAE/RIPK1/PPP2CB/YWHAZ/AKT2/PIK3CA/IRF3	1.22683483171
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/316	41/9376	2.17104044458166	MMP2/DAPK1/THBS1	1.40336855961711
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/316	109/9376	1.63325978399721	PIK3R1/IRS1/PTEN/AKT2/PIK3CA/CREB3L1	1.24191152274134
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/316	86/9376	1.72505151604357	PLCG2/PIK3R1/CDKN1B/AKT2/PIK3CA	1.2614653165158
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/316	65/9376	1.82590068159688	PIK3R1/ITPR2/AKT2/PIK3CA	1.24781850016367
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	9/316	187/9376	1.42801055980505	CYBA/BCL2L1/YWHAE/RIPK1/BCL2/NEK7/ITPR2/IRF3/GSDMD	1.10409448905886
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/316	23/9376	2.58007705008255	GLS/ATP1A1	1.41687584571422
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/316	44/9376	2.02301495972382	HLA-DRA/HLA-DRB1/HLA-DPA1	1.2702407422479
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/316	115/9376	1.54804623004953	PIK3R1/BCL2/ITPR2/AKT2/PIK3CA/CREB3L1	1.1043386026205
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/316	115/9376	1.54804623004953	JUND/AKAP13/BCL2/FGFR1/ITPR2/CREB3L1	1.1043386026205
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/316	91/9376	1.6302684657115	PLCG2/PIK3R1/AKT2/PIK3CA/LYN	1.12828912276685
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/316	45/9376	1.97805907172996	ABCA8/ABCC9/CFTR	1.22820914990271
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/316	45/9376	1.97805907172996	HLA-DRA/HLA-DRB1/HLA-DPA1	1.22820914990271
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/316	119/9376	1.49601106265291	PIK3R1/JAG1/RIPK1/AKT2/PIK3CA/CREB3L1	1.01693874069377
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/316	71/9376	1.67159921554644	PLCG2/TJP1/ADAM10/LYN	1.06083110779127
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	11/316	250/9376	1.30551898734177	DAB2/ASAP1/RAB11FIP1/IGF1R/PDGFRA/TGFBR1/AP2A2/AP2A1/ARPC5/CLTC/SH3GLB1	0.914393349385392
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/316	49/9376	1.81658486179282	GALNT15/GALNT1/GALNT7	1.07027025786358
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/316	73/9376	1.62580197676435	SAMHD1/SERINC3/CCNT2/CREBBP	1.00242509621192
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/316	149/9376	1.39393424517883	PLCG2/PIK3R1/PDGFRB/AGPAT4/PDGFRA/AKT2/PIK3CA	0.905214893450027
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/316	99/9376	1.49852959979542	PLCG2/PIK3R1/IL1R1/ITPR2/PIK3CA	0.931257640569063
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/316	28/9376	2.11934900542495	B3GNT2/B3GALNT1	1.10777168997648
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/316	75/9376	1.58244725738397	ATP1A1/ITPR2/SLC26A4/CREB3L1	0.94577427005791
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/316	100/9376	1.48354430379747	ITGA1/HLA-DRA/IL1R1/HLA-DRB1/HLA-DPA1	0.907864391271968
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/316	52/9376	1.71178188899708	LRP1/LPL/SORT1	0.961197324838196
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	15/316	368/9376	1.2094111172262	MT-ND3/MT-ATP8/ACTB/MT-ND4L/MT-CO2/BCL2L1/ACTG1/MT-ND6/BCL2/DNAH10/ANXA11/WIPI2/DCTN1/MT-ND5/MT-CYB	0.765375462805998
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/316	102/9376	1.45445519980144	CFTR/KCNMA1/ATP1A1/ITPR2/SLC4A2	0.861832163100472
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/316	78/9376	1.52158390133074	PLCG2/PTEN/PIK3C2A/PIK3CA	0.863856866266424
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/316	54/9376	1.64838255977496	HLA-DRA/HLA-DRB1/HLA-DPA1	0.892357207882333
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/316	157/9376	1.32290574860921	PIK3R1/IRS1/MT-CO2/BCL2L11/AKT2/PIK3CA/MT-CYB	0.761989130110746
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/316	105/9376	1.41289933694997	PLCG2/PIK3R1/ITPR2/AKT2/PIK3CA	0.794585480917729
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	10/316	238/9376	1.24667588554409	PLCG2/IL6ST/PIK3R1/NRP1/C1QA/RPS21/C1QB/PIK3CA/IRF3/ADAR	0.719870999882176
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/316	32/9376	1.85443037974684	ACSS1/ACSS3	0.9041705064655
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/316	32/9376	1.85443037974684	WIPI2/PPP2CB	0.9041705064655
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/316	82/9376	1.44736029638777	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1	0.75985042419078
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/316	33/9376	1.79823551975451	SNAP23/VAMP2	0.857847174627506
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/316	109/9376	1.36104981999768	PIK3R1/RIPK1/AKT2/PIK3CA/IRF3	0.708069489125772
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/316	217/9376	1.23058974508546	PIK3R1/JAG1/BCL2/GSTT2B/AHR/PAQR8/AKT2/PIK3CA/CREB3L1	0.641816543480145
NA	NA	hsa04081	Hormone signaling	9/316	219/9376	1.21935148257326	PIK3R1/IRS1/PRLR/IGF2/SSTR1/SLC40A1/PRKG1/IGF1R/PIK3CA	0.613410357896565
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/316	138/9376	1.29003852504128	IGF1R/YWHAE/ITPR2/PPP2CB/YWHAZ/FBXW11	0.641019635402628
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/316	86/9376	1.38004121283485	KCNMA1/ATP1A1/VAMP2/CREB3L1	0.661206546334508
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/316	195/9376	1.21726712106459	PLCG2/PIK3R1/ACTB/CYBA/ACTG1/AKT2/PIK3CA/GSDMD	0.572573708760138
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/316	143/9376	1.24493228290697	ACTN4/C1QA/HLA-DRA/C1QB/HLA-DRB1/HLA-DPA1	0.551198100171527
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/316	14/9376	2.11934900542495	B3GNT2	0.782726969101836
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/316	15/9376	1.97805907172996	B3GALT4	0.707969703642072
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/316	69/9376	1.29003852504128	PDE3A/KCNMA1/ITPR2	0.451585986957348
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/316	154/9376	1.15600854841361	ACTB/MAP2K5/ACTG1/MYL9/ITPR2/ROCK1	0.364553504996188
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/316	16/9376	1.85443037974684	B3GALNT1	0.638798413945292
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/316	155/9376	1.14855042874643	WNT2/ITPR2/CDKN1B/AHR/CREB3L1/ASH2L	0.34826980948948
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/316	72/9376	1.23628691983122	RIPK1/IRF3/ADAR	0.375868697522352
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/316	44/9376	1.34867663981588	GTF2I/TAF15	0.4329391956143
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/316	17/9376	1.74534623976173	INMT	0.574424404295208
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/316	216/9376	1.09892170651664	PIK3R1/CYBA/BCL2L1/BCL2/AKT2/PIK3CA/IRF3/LYN	0.274685553518971
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/316	103/9376	1.15226742042522	PABPC4L/PPP2CB/ACIN1/DDX39B	0.290188737810026
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/316	107/9376	1.10919200283923	ITPR2/AKT2/CREB3L1/CREBBP	0.212144296613793
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/316	138/9376	1.07503210420106	PIK3R1/IRS1/SOCS2/AKT2/PIK3CA	0.16582987405419
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/316	110/9376	1.0789413118527	PIK3R1/IGF1R/AKT2/PIK3CA	0.155531949113283
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/316	21/9376	1.41289933694997	ENPP1	0.35375046351834
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/316	142/9376	1.04474950971653	TRIP12/HERC2/UBE2Q1/FBXW11/SKP2	0.100346585481221
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/316	144/9376	1.03023909985935	C1QA/RIPK1/C1QB/AKT2/IRF3	0.0682916000157357
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/316	144/9376	1.03023909985935	PIK3R1/ITPR2/WIPI2/AKT2/PIK3CA	0.0682916000157357
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/316	23/9376	1.29003852504128	GLS	0.260081355169415
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/316	23/9376	1.29003852504128	MSH3	0.260081355169415
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	9/316	268/9376	0.996410353296807	MT-ND3/MT-ATP8/MT-ND4L/MT-CO2/BCL2L1/MT-ND6/ITPR2/MT-ND5/MT-CYB	-0.0111345500987363
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/316	178/9376	1.00014222727919	CCND2/WNT2/RSPO2/TBL1XR1/FBXW11/CREBBP	0.000357776063436996
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/316	149/9376	0.995667317984878	MT-ND3/MT-ND4L/MT-ND6/ITPR2/MT-ND5	-0.0099559973185145
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/316	90/9376	0.989029535864979	CFTR/ATP1A1/SLC4A2	-0.0195297641093997
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/316	26/9376	1.14118792599805	SLC19A3	0.134630515236274
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/316	122/9376	0.972815936916373	PIK3R1/PPP2CB/AKT2/PIK3CA	-0.0564409893389824
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/316	59/9376	1.00579274833727	ENPP1/NME3	0.00833561600704166
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/316	59/9376	1.00579274833727	GSTT2B/IDH1	0.00833561600704166
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/316	29/9376	1.02313400261894	YAP1	0.0233012242049629
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/316	193/9376	0.92241096609169	PLCG2/PIK3R1/ROCK1/AKT2/PIK3CA/LYN	-0.203400392829665
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/316	30/9376	0.989029535864979	IDH1	-0.0112392626836015
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/316	30/9376	0.989029535864979	B3GALT4	-0.0112392626836015
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/316	98/9376	0.908292430896409	ATP1A1/ITPR2/CREB3L1	-0.170433952661198
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/316	65/9376	0.912950340798442	AGPAT4/LPL	-0.131519657998859
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/316	65/9376	0.912950340798442	ITPR2/CREB3L1	-0.131519657998859
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/316	31/9376	0.957125357288689	ACSS1	-0.044653631972324
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	15/316	480/9376	0.927215189873418	MT-ND3/MT-ATP8/WNT2/MT-ND4L/MT-CO2/BCL2L1/CAPN2/MT-ND6/BCL2/DNAH10/ITPR2/WIPI2/DCTN1/MT-ND5/MT-CYB	-0.305723670908997
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/316	133/9376	0.892357475968402	PLCG2/PIK3R1/IFNGR2/PIK3CA	-0.233490006524367
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/316	133/9376	0.892357475968402	ITPR2/PPP2CB/AKT2/CREB3L1	-0.233490006524367
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/316	67/9376	0.885698091819384	ITPR2/CREBBP	-0.175349465954904
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/316	101/9376	0.881313447800476	WNT2/CREB3L1/CREBBP	-0.223959929621993
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/316	168/9376	0.883062085593731	IFNGR2/CAPN2/STAT6/RIPK1/BCL2	-0.285622496051299
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/316	33/9376	0.899117759877254	IDH1	-0.108416053304678
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9/316	298/9376	0.89610058618639	IL6ST/PRLR/LIFR/IFNGR2/IL1R1/TGFB2/TGFBR1/TGFB3/LTBR	-0.340401308498875
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/316	70/9376	0.847739602169982	IRS1/AKT2	-0.23879187012225
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/316	34/9376	0.872673119880864	POLR2L	-0.138900786686347
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/316	34/9376	0.872673119880864	FBXW11	-0.138900786686347
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/316	140/9376	0.847739602169982	JAG1/TGFBR1/ITPR2/AKT2	-0.338980016569303
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/316	36/9376	0.824191279887482	ENPP1	-0.1973709835023
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/316	36/9376	0.824191279887482	RNASEH2C	-0.1973709835023
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/316	108/9376	0.824191279887482	ACIN1/DDX39B/THOC7	-0.343181887187682
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/316	37/9376	0.801915839890524	GLS	-0.225457923813578
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/316	37/9376	0.801915839890524	UXS1	-0.225457923813578
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/316	37/9376	0.801915839890524	LAMA4	-0.225457923813578
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/316	37/9376	0.801915839890524	CCDC6	-0.225457923813578
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/316	38/9376	0.780812791472352	UXS1	-0.252839632194413
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/316	38/9376	0.780812791472352	ENPP1	-0.252839632194413
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/316	254/9376	0.817701584770258	PLCG2/PDGFRB/CYSLTR2/PDGFRA/FGFR1/ITPR2/FLT1	-0.55007232853913
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/316	42/9376	0.706449668474985	INMT	-0.356072474594976
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/316	42/9376	0.706449668474985	SLC40A1	-0.356072474594976
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/316	82/9376	0.723680148193887	GSTT2B/NME3	-0.4693348030716
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/316	44/9376	0.67433831990794	CHST9	-0.404362351019297
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/316	44/9376	0.67433831990794	PARG	-0.404362351019297
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/316	85/9376	0.698138495904691	ENPP1/NME3	-0.522096816598434
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/316	47/9376	0.631295448424455	ACSS1	-0.473232934947171
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/316	89/9376	0.666761484852795	TRAK2/GLS	-0.589898853208413
NA	NA	hsa03272	Virion - Hepatitis viruses	1/316	48/9376	0.618143459915612	DPP4	-0.495326614576693
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/316	128/9376	0.695411392405063	ENPP1/PDE3A/NME3	-0.647977327789554
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/316	49/9376	0.605528287264273	CREB3L1	-0.517020779423501
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/316	93/9376	0.638083571525793	MMP2/ITPR2	-0.655044308017611
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/316	94/9376	0.631295448424455	JUND/S100A8	-0.670944696480066
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/316	52/9376	0.570593962999026	IGF1R	-0.579874172713604
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/316	243/9376	0.732614471011095	HNRNPU/CRNKL1/HNRNPM/ACIN1/DDX39B/THOC7	-0.78867738541616
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/316	174/9376	0.682089335079296	CAPN2/BCL2/RRBP1/AMFR	-0.790503300885491
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/316	54/9376	0.549460853258322	DNMT3A	-0.620068891377384
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/316	55/9376	0.539470655926352	PSAP	-0.639694297541433
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	6/316	250/9376	0.712101265822785	PSAP/AP2A2/AP2A1/CLTC/SORT1/DMXL1	-0.861657372324386
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/316	100/9376	0.593417721518987	IL6ST/LTBR	-0.76336660334177
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/316	63/9376	0.47096644564999	POLR2L	-0.786817068028374
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/316	63/9376	0.47096644564999	WNT2	-0.786817068028374
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/316	67/9376	0.442849045909692	ACSS1	-0.854719958844649
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/316	116/9376	0.511567001309472	ACSS1/IDH1	-0.988538479749595
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/316	116/9376	0.511567001309472	GLS/ITPR2	-0.988538479749595
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/316	69/9376	0.430012841680426	CREB3L1	-0.887462151471525
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/316	70/9376	0.423869801084991	GSTT2B	-0.903552135640721
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/316	73/9376	0.406450494191087	GSTT2B	-0.950762289923358
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/316	75/9376	0.395611814345992	IDH1	-0.981401814279159
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/316	76/9376	0.390406395736176	LPL	-0.99648508872282
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/316	78/9376	0.380395975332684	PABPC4L	-1.02619960031276
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/316	79/9376	0.375580836404422	GSTT2B	-1.04083870587387
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/316	83/9376	0.35748055513192	IDH1	-1.0980255193998
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/316	91/9376	0.326053693142301	PDE3A	-1.20647998230091
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/316	97/9376	0.305885423463396	PRKG1	-1.28330984265742
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/316	104/9376	0.285296981499513	AGPAT4	-1.36873904163759
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/316	115/9376	0.258007705008255	ITPR2	-1.4951489295571
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/316	154/9376	0.192668091402269	NME3	-1.88653557748818
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/316	370/9376	0.400957919945262	PRLR/SSTR1/NR3C1/CYSLTR2/NPW	-2.19562062680081
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/316	191/9376	0.155344953277222	CREB3L1	-2.20252864449457
NA	NA	hsa04082	Neuroactive ligand signaling	1/316	199/9376	0.149099930029896	SLC6A2	-2.26579081739692
Genetic Information Processing	Translation	hsa03010	Ribosome	1/316	222/9376	0.133652639981754	RPS21	-2.43965362130736
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/316	449/9376	0.0660821516168137	PRKG1	-3.78742602613313