category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	44/226	222/9376	8.22259427569162	RPS26/RPL17/RPL23A/RPS4Y1/RPL41/RPS10/RPL36A/RPL4/RPS16/RPL37/RPL21/RPS25/RPL37A/RPS29/RPL19/RPL23/RPL38/RPL26/MRPL23/RPL32/RPL22/RPL11/RPL7/RPL35A/RPL24/RPLP0/RPSA/RPL39/RPL27/RPL30/RPS8/RPL14/RPS27/MRPS9/RPL13A/RPL9/RPL34/RPS3/RPL31/RPS20/RPL28/RPS11/RPLP2/RPS15A	17.1156565541966
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	44/226	238/9376	7.6698148285863	RPS26/RPL17/RPL23A/RPS4Y1/RPL41/RPS10/RPL36A/RPL4/RPS16/RPL37/RPL21/RPS25/RPL37A/RPS29/RPL19/RPL23/RPL38/RPL26/RPL32/RPL22/RPL11/RPL7/RPL35A/RPL24/RPLP0/RPSA/RPL39/RPL27/RPL30/RPS8/RPL14/RPS27/RPL13A/RPL9/RPL34/ISG15/MAPK13/RPS3/RPL31/RPS20/RPL28/RPS11/RPLP2/RPS15A	16.3797017389826
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/226	170/9376	3.1725143154607	ACTG1/MYH9/PPP2R2B/CLDN23/MYL6/YBX3/CLDN3/ACTN1/ARPC3/CLDN4/ARPC2/TIAM1/CLDN19	4.49242600963906
NA	NA	hsa04382	Cornified envelope formation	15/226	217/9376	2.86774601362098	KRT19/S100A6/COL17A1/PPP2R2B/CLDN23/CLDN3/S100A4/KRT8/S100A13/KRT18/CLDN4/S100A16/PKP2/S100A10/CLDN19	4.37474724486931
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	16/226	248/9376	2.67656294604625	ACTG1/GAPDH/TXN/MAP2K1/TNFRSF10B/TUBB6/DYNLL1/ARPC3/ANXA2/PFN2/MAPK13/PFN1/ARPC2/RPS3/S100A10/MAP2K3	4.20520526002596
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/226	75/9376	4.42525073746313	ALDOA/TPI1/GAPDH/ENO1/PKM/BCAT1/PGK1/PYCR2	4.68044869166185
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/226	200/9376	2.69663716814159	ACTG1/GAPDH/MYH9/CLDN23/CLDN3/TNFRSF10B/TUBB6/ARPC3/CLDN4/MAPK13/ARPC2/RPS3/CLDN19	3.81159354649888
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/226	67/9376	4.33443402456743	LDHA/ALDOA/TPI1/GAPDH/ENO1/PKM/PGK1	4.30464484512452
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/226	232/9376	2.50350930729326	FN1/ACTG1/MYH9/ENAH/CFL1/MAP2K1/ACTN1/ARPC3/PFN2/PFN1/ARPC2/SCIN/PXN/TIAM1	3.64427645694893
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/226	116/9376	3.21879768080561	ACTG1/CD99/CLDN23/CLDN3/ACTN1/CLDN4/MAPK13/PXN/CLDN19	3.77894451424833
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	10/226	156/9376	2.6594054912639	PPP2R2B/CLDN23/CLDN3/MAP2K1/EIF3E/CLDN4/CDKN1A/SOCS3/BID/CLDN19	3.28457113761662
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/226	110/9376	3.01721641190668	LDHA/ALDOA/GAPDH/ENO1/MAP2K1/PGK1/CDKN1A/EIF4E	3.34450614526842
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/226	144/9376	2.5929203539823	ID3/KLF4/MAP2K1/SKIL/BMI1/MAPK13/ID2/ID4/INHBA	3.02730878026087
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/226	78/9376	3.19128658951668	FN1/ACTG1/CAV2/ARPC3/ARPC2/PXN	3.05408431131913
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	9/226	157/9376	2.37821994250606	GADD45A/ZFP36L1/CALM2/IGFBP3/MAP2K1/MAPK13/CDKN1A/HLA-E/MAP2K3	2.7368800205924
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/226	133/9376	2.49544214518597	GADD45A/MAP2K1/PLK2/PLK3/MAPK13/GABARAP/CDKN1A/KLF2	2.72972106178112
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/226	85/9376	2.92847475273295	NME4/ADSL/GUK1/HDDC2/NME2/TYMP	2.806864844479
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/226	41/9376	4.04748543060652	MAP2K1/DAPK1/CDKN1A/TYMP	3.07330537835099
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/226	138/9376	2.40502757470822	FN1/ACTG1/MAP2K1/ARPC3/MAPK13/ARPC2/PXN/MAP2K3	2.61315230362815
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/226	204/9376	2.03366302273122	FN1/ACTG1/TIMP3/CAV2/MAP2K1/MAPK13/PLAU/CDKN1A/PXN/TIAM1	2.34580199848318
NA	NA	hsa03272	Virion - Hepatitis viruses	4/226	48/9376	3.45722713864307	CLDN23/CLDN3/CLDN4/CLDN19	2.68226056092726
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/226	98/9376	2.54000361206429	CFL1/MAP2K1/ARPC3/ARPC2/SCIN/ASAP2	2.40844594767922
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/226	50/9376	3.31893805309735	AOC1/OAT/PYCR2/P4HA1	2.58378132321874
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/226	75/9376	2.76578171091445	GADD45A/IGFBP3/TNFRSF10B/CDKN1A/BID	2.41286005962037
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/226	128/9376	2.26880530973451	NME4/ADSL/PDE4C/GUK1/HDDC2/NME2/PAPSS1	2.27146145965986
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/226	110/9376	2.26291230893001	ID3/TGIF1/SKIL/ID2/ID4/INHBA	2.09388440091025
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/226	59/9376	2.81265936703165	NME4/HDDC2/NME2/TYMP	2.19499466207533
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/226	201/9376	1.85761458195747	NR4A3/GADD45A/IGFBP3/NFKBIZ/BMI1/PLAU/ID2/REL/CDKN1A	1.93159672183951
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/226	36/9376	3.45722713864307	GALNT7/GALNT6/GALNT18	2.32141307502352
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/226	233/9376	1.78054616582476	FN1/ACTG1/ENO1/TPM1/MYH9/TPM4/FHL2/CSRP1/PDLIM3/PKP2	1.89610116956444
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/226	142/9376	2.04512027919731	ACTG1/CAV2/CALM2/TXN/MAPK13/GSTM3/KLF2	1.9721721542618
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/226	37/9376	3.36378856732839	GADD45A/MAP2K1/CDKN1A	2.26406354993788
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	9/226	205/9376	1.82136844377293	GADD45A/TNFAIP3/ISG15/MAPK13/TAP1/CDKN1A/HLA-E/BID/MAP2K3	1.86868417676374
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/226	116/9376	2.14586512053708	ALDOA/TPI1/GAPDH/ENO1/PKM/PGK1	1.9515797897129
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/226	119/9376	2.09176768052354	MAP2K1/TNFAIP3/MAPK13/MAP3K8/SOCS3/MAP2K3	1.88363995246717
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/226	212/9376	1.76122891968609	ACTG1/CALM2/ENAH/MAP2K1/PFN2/MAPK13/PFN1/TIAM1/MAP2K3	1.76185425674444
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/226	214/9376	1.74476883632454	CALM2/CFL1/MAP2K1/MAPK13/TAP1/HLA-E/PXN/BID/MAP2K3	1.73205847417966
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/226	122/9376	2.04033077034673	CSH1/IGFBP3/MAP2K1/MAPK13/SOCS3/MAP2K3	1.81767369609699
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/226	154/9376	1.88576025744167	BCAT1/NME4/RFK/MTHFD1L/RDH13/ADSL/NME2	1.74178001240165
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/226	160/9376	1.81504424778761	CD99/CLDN23/CLDN3/CLDN4/CD276/HLA-E/CLDN19	1.63417760940754
NA	NA	hsa04517	IgSF CAM signaling	11/226	299/9376	1.52626749933406	ACTG1/MYH9/MYL6/MAP2K1/TUBB6/DYNLL1/ACTN1/ARPC3/MAPK13/ARPC2/PXN	1.45345063952586
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/226	76/9376	2.18351187703773	GADD45A/CALM2/MAP2K1/CDKN1A	1.62804818032155
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/226	137/9376	1.81693689038176	ACTG1/CTSH/GADD45A/MAP2K1/TNFRSF10B/BID	1.51378995361779
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/226	49/9376	2.54000361206429	GALNT7/GALNT6/GALNT18	1.6985490855132
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/226	107/9376	1.9386320403606	LDHA/CALM2/PKM/SIK1/PYGL	1.53461745399385
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/226	138/9376	1.80377068103117	CALM2/PPP1R3B/MAP2K1/PYGL/EIF4E/SOCS3	1.49489963366843
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/226	78/9376	2.12752439301112	ENO1/TOB1/BTG2/TOB2	1.57147612539554
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/226	142/9376	1.75296023931198	FHL2/MAP2K1/FOSL1/MAPK13/FOSB/SOCS3	1.42085772020221
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/226	82/9376	2.02374271530326	NME4/GSTM3/NME2/TYMP	1.46327424040331
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/226	54/9376	2.30481809242871	LDHA/BCAT1/ENOPH1	1.51119883911919
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/226	216/9376	1.53654539495247	CALM2/TNFRSF10B/MAPK13/XBP1/ABCG1/HSPA2/BID/MAP2K3	1.25376147598875
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/226	87/9376	1.90743566269962	GADD45A/MAP2K1/AREG/CDKN1A	1.33635024889311
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/226	88/9376	1.88576025744167	CLU/PROCR/PLAU/SERPINE2	1.31197552639147
NA	NA	hsa04518	Integrin signaling	6/226	154/9376	1.61636593495001	FN1/ACTG1/FLNB/ACTN1/LIMS1/PXN	1.21203661690801
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/226	59/9376	2.10949452527374	GPX3/PRDX6/GSTM3	1.34351473027482
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/226	59/9376	2.10949452527374	GADD45A/MAP2K1/CDKN1A	1.34351473027482
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/226	60/9376	2.07433628318584	MAP2K1/MAPK13/PXN	1.31198974140814
NA	NA	hsa04519	Cadherin signaling	13/226	404/9376	1.3349688951196	KRT19/ACTG1/ENAH/KRT8/MAP2K1/ACTN1/KRT18/ARPC3/MAPK13/PKP2/ARPC2/TEAD4/MAP2K3	1.0816327826219
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	12/226	368/9376	1.35282801077337	GPX3/ACTG1/NDUFA7/HNRNPA1/NDUFA13/TUBB6/PFN2/MAPK13/PFN1/XBP1/BID/MAP2K3	1.08518076568167
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/226	157/9376	1.58547996167071	NDUFA7/NDUFA13/MAPK13/XBP1/SOCS3/BID	1.16265072078415
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/226	227/9376	1.4620872480605	CALM2/MAP2K1/MAPK13/TAP1/CDKN1A/HLA-E/PXN/BID	1.10759097740829
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/226	93/9376	1.78437529736416	CALM2/MAP2K1/MAPK13/MAP2K3	1.19467704095857
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/226	194/9376	1.49694370951556	ACTG1/TPM1/MYH9/MYL6/TPM4/TUBB6/DYNLL1	1.0991797757082
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/226	94/9376	1.76539258143476	TNFAIP3/FOSL1/MAPK13/FOSB	1.17207851204972
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	7/226	196/9376	1.48166877370417	CALM2/ZFP36/MAP2K1/MAPK13/CDKN1A/HLA-E/BID	1.07098773671547
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/226	34/9376	2.44039562727746	BHLHE40/NFIL3	1.32230193073851
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/226	35/9376	2.37067003792668	ALDOA/TPI1	1.27673147863096
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/226	10/9376	4.14867256637168	PAPSS1	1.56559611256618
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	7/226	203/9376	1.43057674702472	FN1/ACTG1/FLNB/CAV2/MAP2K1/ACTN1/PXN	0.974702781290635
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/226	134/9376	1.54801215163122	MYH9/CALM2/MYL6/CALD1/MAP2K1	1.00412762769688
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/226	205/9376	1.41661990071228	PKM/ACTN1/REL/SCIN/CDKN1A/HLA-E/PXN	0.94784627056009
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/226	69/9376	1.80377068103117	MAP2K1/MAPK13/MAP2K3	1.05312799981285
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/226	70/9376	1.77800252844501	ACTG1/HLA-E/BID	1.0267809795774
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/226	71/9376	1.75296023931198	MAP2K1/MAPK13/SOCS3	1.0008577119129
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/226	71/9376	1.75296023931198	LDHA/PKM/MAP2K1	1.0008577119129
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/226	73/9376	1.70493393138562	GADD45A/MAP2K1/CDKN1A	0.950227611248081
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/226	73/9376	1.70493393138562	GADD45A/MAP2K1/CDKN1A	0.950227611248081
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/226	253/9376	1.31183322256812	ACTG1/ACTN1/ARPC3/PFN2/MAPK13/PFN1/ARPC2/PXN	0.790211083402315
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/226	109/9376	1.52244864820979	MAP2K1/MAPK13/MAP3K8/MAP2K3	0.862217013098024
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/226	109/9376	1.52244864820979	PPP1R3B/SLC27A6/PYGL/SOCS3	0.862217013098024
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/226	42/9376	1.9755583649389	FTH1/PRNP	0.995802735133853
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/226	75/9376	1.65946902654867	GSTM3/CDKN1A/BID	0.901134304926043
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/226	76/9376	1.6376339077783	PLIN2/SLC27A6/SCD	0.877134182943804
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/226	77/9376	1.61636593495001	GADD45A/MAP2K1/CDKN1A	0.853483594840378
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/226	77/9376	1.61636593495001	GADD45A/MAP2K1/CDKN1A	0.853483594840378
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/226	44/9376	1.88576025744167	ARHGDIB/DYNLL1	0.925517157531244
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/226	78/9376	1.59564329475834	CALM2/CFL1/MAPK13	0.83017203243375
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/226	45/9376	1.84385447394297	TAP1/ABCG1	0.891741606389849
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/226	187/9376	1.33112488760589	GBP2/TXN/TNFAIP3/GBP1/MAPK13/GABARAP	0.718799575799744
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/226	115/9376	1.44301654482493	GATA3/MAP2K1/PDE4C/CDKN1A	0.751223619756067
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/226	46/9376	1.80377068103117	FTH1/BLVRB	0.858814889262414
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/226	46/9376	1.80377068103117	PSMB8/PSMB10	0.858814889262414
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/226	47/9376	1.76539258143476	LDHA/PKM	0.826694297094396
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/226	47/9376	1.76539258143476	PKM/SOCS3	0.826694297094396
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/226	154/9376	1.34697161245834	TPM1/PPP2R2B/CALM2/TPM4/MAPK13	0.682293221414373
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/226	154/9376	1.34697161245834	ACTG1/CALM2/MYL6/MAP2K1/CDKN1A	0.682293221414373
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/226	82/9376	1.51780703647744	TAP1/HSPA2/HLA-E	0.740121210779579
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/226	16/9376	2.5929203539823	MIF	1.00217932576843
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/226	157/9376	1.32123330139226	ACTG1/PPP2R2B/TEAD4/ID2/AREG	0.637907620848068
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/226	120/9376	1.38289085545723	ARHGDIB/CALM2/MAP2K1/MAPK13	0.663411896350471
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/226	122/9376	1.36022051356449	PPP2R2B/MAP2K1/MAPK13/MAP3K8	0.629379973143052
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/226	17/9376	2.44039562727746	PAPSS1	0.934159085554205
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/226	17/9376	2.44039562727746	MYH9	0.934159085554205
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/226	86/9376	1.44721136036221	MAP2K1/AREG/CDKN1A	0.654762060336525
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/226	125/9376	1.32757522123894	PPP2R2B/MAP2K1/MAPK13/BID	0.57943005699549
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/226	163/9376	1.27259894673978	MAP2K1/MAPK13/CDKN1A/BID/MAP2K3	0.551755601466422
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/226	90/9376	1.38289085545723	MAP2K1/MAPK13/MAP2K3	0.573602743754552
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/226	19/9376	2.18351187703773	IDS	0.811540909017803
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/226	168/9376	1.23472397808681	FTH1/TNFRSF10B/TNFAIP3/PYGL/BID	0.48245715692321
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/226	20/9376	2.07433628318584	CYB5R1	0.755856662050522
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/226	93/9376	1.33828147302312	FN1/GADD45A/CDKN1A	0.515234366202561
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/226	170/9376	1.22019781363873	ACTG1/GADD45A/MAP2K1/GSTM3/CDKN1A	0.455335266707558
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/226	56/9376	1.48166877370417	EEF1A1/EEF1G	0.568151110976134
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/226	133/9376	1.24772107259299	MAP2K1/TNFRSF10B/HLA-E/BID	0.452180267542208
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/226	21/9376	1.9755583649389	BCAT1	0.703348101162438
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/226	173/9376	1.19903831398025	ACTG1/MAP2K1/TNFRSF10B/SOCS3/BID	0.415264050226964
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/226	22/9376	1.88576025744167	AOC1	0.653669405615993
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/226	99/9376	1.25717350496112	MAP2K1/MAPK13/CDKN1A	0.404267988470473
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/226	99/9376	1.25717350496112	CALM2/MAPK13/MAP2K3	0.404267988470473
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/226	99/9376	1.25717350496112	ACTG1/TPM1/TPM4	0.404267988470473
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/226	139/9376	1.19386260902782	KRT19/CALM2/MAP2K1/KRT18	0.361880592150253
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	8/226	300/9376	1.10631268436578	GADD45A/MAP2K1/MAPK13/NR4A1/MAP3K8/AREG/DUSP10/MAP2K3	0.294122181588103
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/226	63/9376	1.31703890995926	GADD45A/CDKN1A	0.396796059057794
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/226	103/9376	1.20835123292379	FN1/SERPINB9/ACTN1	0.334144154461116
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/226	105/9376	1.18533501896334	GADD45A/TNFAIP3/PLAU	0.300136045800141
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/226	105/9376	1.18533501896334	CALM2/PLK3/MAPK13	0.300136045800141
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/226	105/9376	1.18533501896334	ACTG1/TPM1/TPM4	0.300136045800141
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/226	268/9376	1.08360850614186	NDUFA7/CALM2/NDUFA13/TXN/TUBB6/UBE2L6/XBP1	0.218240657111195
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/226	106/9376	1.17415261312406	MAP2K1/PLAU/CDKN1A	0.283382072161232
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/226	67/9376	1.23840972130498	CALM2/MAP2K1	0.307779122418291
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/226	27/9376	1.53654539495247	SCD	0.438768139806514
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	12/226	480/9376	1.03716814159292	GPX3/NDUFA7/CALM2/PRNP/NDUFA13/MAP2K1/TUBB6/MAPK13/UBE2L6/XBP1/BID/MAP2K3	0.131378224768811
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/226	109/9376	1.14183648615734	GATA3/EBI3/MAPK13	0.234078185218687
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/226	69/9376	1.20251378735411	CALM2/FOSB	0.265340531626695
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/226	235/9376	1.05923554886085	ACTG1/NDUFA7/NDUFA13/COX16/MAPK13/MAP2K3	0.144526938870975
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/226	70/9376	1.18533501896334	MAP2K1/CDKN1A	0.244598783890228
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/226	29/9376	1.43057674702472	TEAD4	0.364957893063779
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/226	29/9376	1.43057674702472	CALM2	0.364957893063779
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/226	155/9376	1.0706251784185	ACTG1/TUBB6/TAP1/HLA-E	0.13933675972106
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/226	72/9376	1.15240904621436	ISG15/MAPK13	0.204019394046789
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/226	31/9376	1.33828147302312	ALDOA	0.296482263643889
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/226	117/9376	1.06376219650556	ACTG1/SMARCA1/CHD3	0.109069536849273
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/226	32/9376	1.29646017699115	LDHA	0.264000195555703
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/226	32/9376	1.29646017699115	GABARAP	0.264000195555703
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/226	32/9376	1.29646017699115	BID	0.264000195555703
Human Diseases	Immune disease	hsa05310	Asthma	1/226	32/9376	1.29646017699115	PRG2	0.264000195555703
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/226	76/9376	1.09175593851886	ACTG1/CALM2	0.126220185566055
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/226	33/9376	1.25717350496112	BCAT1	0.232578374057344
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	8/226	333/9376	0.996678094023227	FN1/PPP2R2B/PKM/MAP2K1/ISG15/CDKN1A/HLA-E/PXN	-0.00970024041382195
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/226	250/9376	0.995681415929204	CAV2/ARPC3/ARPC2/ASAP2/HLA-E/ARF5	-0.0108767829313695
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/226	78/9376	1.06376219650556	EEF1A1/MAPK13	0.0888679394719557
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/226	80/9376	1.03716814159292	MAP2K1/EIF4E	0.0524683121497443
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/226	36/9376	1.15240904621436	PYGL	0.143985204733352
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/226	37/9376	1.12126285577613	ADSL	0.116146941193818
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/226	37/9376	1.12126285577613	MIF	0.116146941193818
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/226	83/9376	0.999680136475104	ECH1/CRAT	-0.000459997114282244
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/226	38/9376	1.09175593851886	TAP1	0.0890693649702153
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/226	39/9376	1.06376219650556	MTHFD1L	0.0627077479777528
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/226	39/9376	1.06376219650556	HLA-E	0.0627077479777528
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/226	86/9376	0.96480757357481	ACTG1/PKP2	-0.0515252242602603
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/226	87/9376	0.953717831349812	TPM1/TPM4	-0.0681582068429958
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/226	133/9376	0.93579080444474	PPP2R2B/CALM2/MAPK13	-0.117204931017521
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/226	224/9376	0.926042983565107	ZFP36/MAP2K1/FOSL1/CDKN1A/HLA-E	-0.176065675290133
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/226	180/9376	0.921927236971485	TAP1/HLA-E/SOCS3/BID	-0.166213246200739
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/226	89/9376	0.932285969971164	MAP2K1/TUBB6	-0.100870750729701
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	4/226	181/9376	0.916833716325233	CALM2/PLK3/MAPK13/BID	-0.177557910924493
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/226	42/9376	0.987779182469448	AOC1	-0.01247441871226
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	5/226	227/9376	0.913804530037815	NDUFA7/NDUFA13/MAP2K1/MAPK13/GSTM3	-0.206604543242194
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/226	362/9376	0.916833716325233	FN1/CSH1/PPP2R2B/MAP2K1/NR4A1/AREG/CDKN1A/EIF4E	-0.253613352149302
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/226	138/9376	0.901885340515583	CALM2/MAP2K1/MAPK13	-0.182479371271158
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/226	184/9376	0.901885340515583	ENAH/EFNB1/CFL1/SEMA4A	-0.211235601315261
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	6/226	275/9376	0.905164923572003	NDUFA7/CAV2/PRNP/NDUFA13/TUBB6/MAPK13	-0.250853461973616
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/226	44/9376	0.942880128720837	KRTCAP2	-0.0596836677427051
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/226	44/9376	0.942880128720837	HLA-E	-0.0596836677427051
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/226	93/9376	0.892187648682082	ACTG1/ACTN1	-0.164208308553446
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/226	93/9376	0.892187648682082	GATA3/MAPK13	-0.164208308553446
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/226	140/9376	0.889001264222503	CALM2/MAP2K1/KLF2	-0.207955015326786
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/226	45/9376	0.921927236971485	HLA-E	-0.0825032434716313
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/226	142/9376	0.876480119655989	MID1/UBE2L6/SOCS3	-0.233085581976559
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/226	144/9376	0.864306784660767	MAPK13/SCD/MAP2K3	-0.257881859059259
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/226	191/9376	0.868831951072603	CALM2/MAP2K1/FOSB/SLC29A1	-0.287828949531441
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/226	98/9376	0.846667870688098	CALM2/NR4A1	-0.239799532025292
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/226	48/9376	0.864306784660767	BCAT1	-0.148120030975575
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/226	99/9376	0.838115669974077	KRT19/KRT18	-0.254476651762262
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/226	99/9376	0.838115669974077	MAP2K1/SLC44A2	-0.254476651762262
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/226	148/9376	0.840947141832098	GADD45A/MAP2K1/CDKN1A	-0.306512262102993
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/226	49/9376	0.846667870688098	FOSB	-0.169117881271339
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/226	149/9376	0.835303201282889	NDUFA7/NDUFA13/MAPK13	-0.318476463729872
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/226	101/9376	0.8215193200736	CALM2/MAP2K1	-0.283415925544283
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/226	101/9376	0.8215193200736	FN1/MAPK13	-0.283415925544283
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/226	150/9376	0.829734513274336	GADD45A/MAP2K1/CDKN1A	-0.330365615333482
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/226	51/9376	0.813465209092487	LPCAT1	-0.209918069244138
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/226	51/9376	0.813465209092487	ACTG1	-0.209918069244138
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/226	103/9376	0.80556748861586	PPP2R2B/EIF4A3	-0.311821947029075
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/226	103/9376	0.80556748861586	PPP2R2B/MAPK13	-0.311821947029075
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	8/226	388/9376	0.85539640543746	GAPDH/NDUFA7/CALM2/NDUFA13/MAP2K1/TUBB6/XBP1/BID	-0.45718579741088
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/226	105/9376	0.790223345975558	GABARAP/CITED2	-0.339717425191701
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/226	250/9376	0.829734513274336	CTSH/LITAF/IDS/SLC29A1/AP3S1	-0.428830540163008
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/226	155/9376	0.802968883813874	MAP2K1/NR4A1/CDKN1A	-0.388723652220999
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/226	298/9376	0.835303201282889	CSH1/GDF15/EBI3/TNFRSF10B/TNFRSF12A/INHBA	-0.454074915982406
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/226	205/9376	0.809497086121304	GAPDH/NDUFA7/NDUFA13/MAPK13	-0.433410588745382
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/226	54/9376	0.768272697476237	HLA-E	-0.268379195995294
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/226	157/9376	0.792739980835353	SLC16A1/MAP2K1/MAPK13	-0.4115785790241
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/226	108/9376	0.768272697476237	EEF1A1/EIF4A3	-0.380649603787887
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/226	56/9376	0.740834386852086	KRTCAP2	-0.305698104330991
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/226	110/9376	0.754304102976669	MAP2K1/MAPK13	-0.407359087806084
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/226	57/9376	0.727837292345909	SCD	-0.323899814769517
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/226	112/9376	0.740834386852086	MAPK13/MAP2K3	-0.433627110338677
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/226	60/9376	0.691445427728614	MAP2K1	-0.376809793935452
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/226	168/9376	0.740834386852086	CSH1/CDKN1A/SOCS3	-0.532695065543581
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/226	61/9376	0.680110256782243	FTH1	-0.393915539854555
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/226	169/9376	0.736450751426926	MAP2K1/DAPK1/GABARAP	-0.543344623226535
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/226	65/9376	0.638257317903336	NR4A1	-0.459925596222479
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/226	65/9376	0.638257317903336	MAP2K1	-0.459925596222479
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/226	323/9376	0.770651250719198	TPM1/TIMP3/MAP2K1/BMI1/PLAU/CDKN1A	-0.659220475008147
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/226	122/9376	0.680110256782243	PPP2R2B/SCD	-0.558913749810885
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/226	122/9376	0.680110256782243	ACTG1/MAP2K1	-0.558913749810885
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/226	226/9376	0.734278330331271	CALM2/MAP2K1/PDE4C/TIAM1	-0.635477174606207
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/226	66/9376	0.628586752480558	GATA3	-0.475865070743492
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/226	68/9376	0.610098906819365	RDH13	-0.507119175450182
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/226	68/9376	0.610098906819365	MAP2K1	-0.507119175450182
Organismal Systems	Immune system	hsa04611	Platelet activation	2/226	126/9376	0.658519454979632	ACTG1/MAPK13	-0.606470502955084
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/226	69/9376	0.601256893677055	CALM2	-0.522446936559464
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/226	70/9376	0.592667509481669	SOCS3	-0.53758341179694
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/226	70/9376	0.592667509481669	GSTM3	-0.53758341179694
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/226	71/9376	0.584320079770659	MAPK13	-0.552534426291925
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/226	130/9376	0.638257317903336	MAP2K1/MAPK13	-0.652715305581406
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/226	238/9376	0.697255893507846	CALM2/MAP2K1/REL/TIAM1	-0.743477636938736
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/226	73/9376	0.568311310461874	GSTM3	-0.581902067696375
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/226	75/9376	0.553156342182891	GPX3	-0.610591449768281
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/226	136/9376	0.610098906819365	TNFAIP3/BID	-0.719808933174142
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/226	193/9376	0.644871383373837	MAP2K1/PXN/TIAM1	-0.783432064866054
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/226	138/9376	0.601256893677055	NDUFA7/NDUFA13	-0.741605706251019
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/226	78/9376	0.53188109825278	TPI1	-0.652436153489838
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/226	195/9376	0.638257317903336	ACTG1/MAP2K1/MAPK13	-0.80223457791461
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/226	79/9376	0.525148426122998	GSTM3	-0.666084492481627
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/226	144/9376	0.576204523107178	ATXN10/XBP1	-0.805413632279282
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/226	83/9376	0.499840068237552	BMI1	-0.71928215436582
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/226	89/9376	0.466142984985582	FN1	-0.795264406266908
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/226	89/9376	0.466142984985582	GABARAP	-0.795264406266908
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/226	90/9376	0.460963618485742	EIF4E	-0.807521890411519
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/226	91/9376	0.455898084216668	MAP2K1	-0.819670505368569
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/226	91/9376	0.455898084216668	PDE4C	-0.819670505368569
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/226	93/9376	0.446093824341041	CALM2	-0.843650983309454
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/226	158/9376	0.525148426122998	GADD45A/CDKN1A	-0.946013609156883
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/226	158/9376	0.525148426122998	MAP2K1/EIF4E	-0.946013609156883
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/226	217/9376	0.573549202724196	KLF4/MAP2K1/GSTM3	-0.998858751055664
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/226	97/9376	0.42769820271873	CALM2	-0.890409326452457
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/226	98/9376	0.423333935344049	CALM2	-0.90186090195142
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/226	166/9376	0.499840068237552	CALM2/MAP2K1	-1.02179185565214
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/226	100/9376	0.414867256637168	TNFRSF10B	-0.924492393358489
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/226	103/9376	0.40278374430793	COL17A1	-0.957788048519265
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/226	104/9376	0.398910823689585	LPCAT1	-0.968719800393004
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/226	174/9376	0.476858915674906	KRTCAP2/XBP1	-1.09466604889843
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/226	178/9376	0.466142984985582	FOSL1/APCDD1	-1.13010179077019
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/226	243/9376	0.512181798317491	HNRNPA1/EIF4A3/SNRPA1	-1.21083152480584
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/226	115/9376	0.360754136206233	MAP2K1	-1.08396988176371
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/226	115/9376	0.360754136206233	MAP2K1	-1.08396988176371
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	4/226	308/9376	0.538788644983335	GPX3/NDUFA7/NDUFA13/TUBB6	-1.29344779364823
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/226	143/9376	0.290116962683334	ACTN1	-1.34435111125124
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/226	149/9376	0.27843440042763	MAP2K1	-1.39530131909636
NA	NA	hsa04081	Hormone signaling	1/226	219/9376	0.189437103487291	CSH1	-1.9074865357574
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/226	254/9376	0.163333565605184	CALM2	-2.12448408135358
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/226	370/9376	0.112126285577613	CSH1	-2.73851674180475
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/226	449/9376	0.0923980527031555	CALM2	-3.09738458665935