category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	44/886	203/9376	2.29372060180809	FN1/FLNB/ITGA5/ACTG1/CAV2/FLT1/ACTB/PXN/ACTN1/FLNA/LAMA3/MAPK3/ITGA1/PAK2/MAP2K1/PDGFB/COL4A2/ZYX/LAMA4/CAPN2/ACTN4/PTK2/ITGA2/VAV2/ITGA3/TLN2/LAMB3/VCL/COL4A1/PARVA/RAP1A/RAC1/VEGFA/RAP1B/CAV1/VASP/FLT4/PIP5K1C/PIK3R1/ITGB6/RASGRF1/CRKL/THBS3/ERBB2	6.01979179014803
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	48/886	233/9376	2.18006374795338	FN1/TPM1/ITGA5/HSPG2/ACTG1/FHL2/COL27A1/SYNE1/PKP2/ACTB/CSRP1/SDC4/MYH9/COL5A1/PDLIM5/ITGA1/AGRN/TNNI2/ENO1/TPM4/PDLIM3/TMOD3/TPM3/COL4A2/ZYX/MYOZ1/TPM2/ITGA2/SUN2/ITGA3/TLN2/ATP1B1/SYNE3/VCL/COL4A1/BGN/PDLIM4/INF2/AMPD2/COL11A1/FBLN2/VCAN/TMEM43/NID2/ITGB6/ATP1A1/CAPZA1/THBS3	5.89233898167847
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	24/886	85/9376	2.9879697251361	TYMP/UPP1/UCK2/CDA/ADA/NME2/AK5/NME4/GUK1/NT5E/HDDC2/ADK/DCTD/CMPK1/AMPD2/AK1/GDA/ADSL/AK4/CTPS1/ENTPD4/HPRT1/CTPS2/ITPA	5.94753016051701
NA	NA	hsa04518	Integrin signaling	34/886	154/9376	2.33637243118056	FN1/FLNB/ITGA5/ACTG1/FLT1/TGFB1/LIMS1/ACTB/PXN/ACTN1/FLNA/LAMA3/ITGA1/PDGFB/COL4A2/LAMA4/ACTN4/PTK2/ITGA2/ITGA3/TLN2/LAMB3/VCL/COL4A1/LIMS2/PARVA/RAC1/VEGFA/FLT4/PIK3R1/ITGB6/ICAM3/THBS3/ERBB2	5.40161918669756
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	45/886	232/9376	2.05261928854986	FN1/ITGA5/ACTG1/FGFR1/ACTB/PXN/RGCC/ACTN1/TIAM1/MYH9/MAPK3/RRAS/ITGA1/ARPC1B/ARPC2/PAK2/GSN/MAP2K1/PFN2/PDGFB/ACTN4/PTK2/PFN1/ITGA2/VAV2/LIMK1/ITGA3/CHRM5/ACTR3/ARPC3/VCL/RAC1/IQGAP1/ENAH/ARPC1A/SSH2/PIP4K2A/PIP5K1C/PIK3R1/ITGB6/APC/LPAR2/CRKL/C9/FGFR3	5.24440063962606
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	41/886	204/9376	2.12685345018369	FN1/TIMP3/ITGA5/HSPG2/ACTG1/CAV2/TGFB1/FGFR1/ACTB/SDC4/MMP2/PXN/TIAM1/IGF2/FLNA/TGFB2/MAPK3/RRAS/PLAUR/CDKN1A/MAP2K1/HIF1A/WNT7A/PTK2/ITGA2/VAV2/ITPR3/RAC1/PLAU/VEGFA/STAT3/IQGAP1/CAV1/CD63/GPC3/FZD8/TNF/PIK3R1/ERBB2/MAPK13/MYC	5.25653007379173
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	27/886	110/9376	2.59749640878309	LDHA/FLT1/ALDOA/IFNGR2/EGLN3/TIMP1/EIF4EBP1/MAPK3/CDKN1A/PFKP/SERPINE1/ENO1/EPAS1/MAP2K1/HK2/HIF1A/EIF4E/GAPDH/EGLN1/PGK1/VEGFA/STAT3/INSR/PIK3R1/PFKFB3/PDK1/ERBB2	5.44425851682836
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	41/886	212/9376	2.04659482942204	ACTG1/FLT1/FGFR1/ACTB/TIAM1/RALB/MAPK3/RRAS/MAP2K3/PRKD3/MAP2K1/CSF1R/PFN2/PDGFB/PFN1/VAV2/APBB1IP/CALM3/TLN2/CALM2/GNAQ/EFNA1/RAP1A/ID1/RAC1/VEGFA/RAP1B/ENAH/VASP/RALA/INSR/FLT4/ADCY7/ADORA2B/PIK3R1/PARD6G/LPAR2/CRKL/RALGDS/FGFR3/MAPK13	4.9791204113259
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	33/886	156/9376	2.23858308734155	CLDN19/JAK1/SOCS3/SCARB1/MAPK3/STAT1/MX1/CDKN1A/EIF3E/MAP2K1/IFNAR2/CLDN23/PPP2R2B/YWHAZ/OAS3/IFNAR1/IRF9/STAT3/CLDN4/CLDN3/YWHAG/YWHAQ/RXRA/TNF/MX2/PIK3R1/E2F3/EIF2AK2/OAS2/OAS1/IFIT1/MYC/TRAF3	5.03930492663137
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	35/886	170/9376	2.17872792457841	ACTG1/CLDN19/ACTB/JAM2/ACTN1/TIAM1/RAB8B/MYH9/ARPC1B/RUNX1/ARPC2/MYL6/YBX3/F11R/LLGL2/CLDN23/AMOTL2/PPP2R2B/ACTN4/ARHGEF2/TUBA1C/ACTR3/PRKAG2/ARPC3/RAP1A/RAC1/MICALL2/CLDN4/CLDN3/VASP/ARPC1A/PARD6G/MPDZ/ERBB2/CGNL1	5.01015545908405
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	24/886	98/9376	2.5916063942507	PLPP2/ASAP3/MAPK3/LYN/ARPC1B/ARPC2/GSN/MAP2K1/SPHK1/VAV2/MARCKSL1/LIMK1/ACTR3/MARCKS/ARPC3/ASAP2/RAC1/VASP/ASAP1/ARPC1A/DNM2/PIP5K1C/PIK3R1/CRKL	5.11646706655158
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	44/886	238/9376	1.95640874860102	RPS26/RPS4Y1/RPL17/ISG15/RPL41/RPS27L/JAK1/RPL36A/RPL4/RPS10/RPL37/MAPK3/STAT1/MX1/RPL23A/RPL37A/RPL38/RPLP0/RPS29/IFNAR2/RPL23/FOS/OAS3/RPS20/ADAR/C1S/RPS11/IFNAR1/IRF9/STAT3/CFB/RPL21/TNF/MX2/PIK3R1/EIF2AK2/OAS2/OAS1/C9/RPL13A/RPL31/MAPK13/C2/TRAF3	4.82786475801308
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	59/886	362/9376	1.72475462379806	FN1/CSH1/ITGA5/FLT1/IL2RB/FGFR1/JAK1/PKN1/IGF2/EIF4EBP1/LAMA3/MAPK3/CDKN1A/ITGA1/GNB1/MAP2K1/CSF1R/PDGFB/EIF4E/COL4A2/GYS1/IFNAR2/GNB5/LAMA4/PPP2R2B/PPP2R5E/OSMR/EPOR/PTK2/ITGA2/YWHAZ/ITGA3/DDIT4/LAMB3/COL4A1/EFNA1/IFNAR1/AREG/RAC1/VEGFA/GNG10/PPP2R3A/YWHAG/CREB3L2/PPP2R5A/INSR/FLT4/YWHAQ/RBL2/RXRA/PIK3R1/ITGB6/PIK3AP1/LPAR2/THBS3/GH2/ERBB2/FGFR3/MYC	4.54292071276322
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	55/886	333/9376	1.74784265077719	FN1/ITGA5/ISG15/HLA-G/JAK1/PXN/EIF4EBP1/IRF1/LAMA3/TCF7L2/MAPK3/PKM/STAT1/MX1/HLA-E/HES4/CDKN1A/ITGA1/MAP2K1/NOTCH2/COL4A2/IFNAR2/WNT7A/MAML2/LLGL2/LAMA4/PPP2R2B/PPP2R5E/PTK2/ITGA2/ITGA3/FOXO1/LAMB3/COL4A1/IFNAR1/VEGFA/IRF9/HES2/PPP2R3A/CREB3L2/PPP2R5A/RBL2/FZD8/TNF/HEY1/MX2/PIK3R1/ITGB6/PARD6G/APC/EIF2AK2/THBS3/AXIN1/TUBG1/TRAF3	4.48874294400933
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	20/886	78/9376	2.71343404526249	FN1/ITGA5/ACTG1/CAV2/ACTB/PXN/CLTB/ARPC1B/ARPC2/PTK2/ACTR3/ARPC3/VCL/RAC1/CAV1/ARPC1A/DNM2/MAD2L2/PIK3R1/CRKL	4.90872357495246
NA	NA	hsa04519	Cadherin signaling	63/886	404/9376	1.65022461614107	KRT19/ACTG1/KRT8/PKP2/FGFR1/ACTB/LIMA1/WWTR1/ACTN1/TCF7L2/MAPK3/RRAS/APH1B/KRT18/ARPC1B/KRT14/ARPC2/MAP2K3/KRT17/PTK2B/MAP2K1/KRT15/WNT7A/KRT7/AMOTL2/ACTN4/PTK2/FAT2/YWHAZ/VAV2/ANKRD6/ACTR3/CTNND2/ARPC3/VCL/WTIP/ADAM10/RAC1/PCDH1/TMC4/KRT10/ENAH/VASP/ARPC1A/TEAD4/YWHAG/MYO1E/SAV1/FLT4/YWHAQ/TEAD1/FZD8/TMC6/APC/FAT1/TAOK3/MPDZ/AXIN1/ERBB2/LIMD1/CELSR1/MAPK13/KRT78	4.31576820397294
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	18/886	70/9376	2.72118671396324	EGLN3/TGFB1/TGFB2/MAPK3/ARNT2/CDKN1A/EPAS1/PAK2/MAP2K1/HIF1A/PDGFB/EGLN1/RAP1A/RAC1/VEGFA/RAP1B/PIK3R1/CRKL	4.66921782700735
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/886	77/9376	2.61123977602533	TGFB1/JAK1/GADD45A/TGFB2/RALB/MAPK3/STAT1/CDKN1A/MAP2K1/SMAD3/RAC1/VEGFA/STAT3/RALA/PIK3R1/E2F3/CDKN2A/RALGDS/ERBB2	4.58602129836905
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	28/886	138/9376	2.14715215755553	FN1/ITGA5/ACTG1/ACTB/PKN1/PXN/WIPF1/MAPK3/ARPC1B/ARPC2/MAP2K3/PTK2B/MAP2K1/PTK2/VAV2/LIMK1/FOS/ACTR3/ARPC3/GNAQ/RAC1/ARPC1A/TNF/PIP5K1C/PIK3R1/CRKL/RPS6KA1/MAPK13	4.38551140262967
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	21/886	93/9376	2.38957256244084	ACTG1/FGFR1/ACTB/HEG1/ACTN1/TCF7L2/MAPK3/PTPRF/SMAD3/ACTN4/SNAI1/VCL/ARHGAP29/RAP1A/RAC1/RAP1B/CCM2/IQGAP1/INSR/ERBB2/CSNK2B	4.35037989626673
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	30/886	157/9376	2.02211326939943	ZFP36L1/IGFBP3/HLA-G/TGFB1/PPP3CA/EIF4EBP1/GADD45A/TGFB2/MAPK3/RRAS/HLA-E/CDKN1A/SERPINE1/MAP2K3/MAP2K1/SMAD3/CAPN2/CALM3/ZFP36L2/CALM2/FOXO1/ITPR3/RBL2/PIK3R1/E2F3/CDKN2A/HIPK3/PPP3CC/MAPK13/MYC	4.17210854834366
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	35/886	196/9376	1.8897129958078	HLA-G/JAK1/PPP3CA/TCF7L2/MAPK3/STAT1/HLA-E/ZFP36/LYN/CDKN1A/GNB1/MAP2K1/HIF1A/PDGFB/IFNAR2/GNB5/FOS/CCR1/CALM3/CALM2/ITPR3/IFNAR1/RAC1/VEGFA/IRF9/STAT3/GNG10/CXCL2/PIK3R1/E2F3/EIF2AK2/PPP3CC/MAPK13/MYC/TRAF3	4.06635493170184
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	39/886	227/9376	1.81812034486531	HLA-G/TAP1/JAK1/PXN/PPP3CA/EIF4EBP1/MAPK3/HLA-E/CDKN1A/TAP2/TAPBP/B2M/GNB1/PTK2B/MAP2K1/IL10RA/PTGER3/GNB5/PTK2/CCR1/CALM3/CALM2/ITPR3/GNAQ/RAC1/VEGFA/IL1R1/STAT3/GNG10/CREB3L2/ADCY7/TNF/PIK3R1/E2F3/CDKN2A/CRKL/PPP3CC/MAPK13/MYC	4.03080660530802
NA	NA	hsa04517	IgSF CAM signaling	48/886	299/9376	1.69884566312086	ITGA5/IL1RAP/ACTG1/TUBB2A/TUBB6/FGFR1/ACTB/JAM2/PVR/PXN/ACTN1/MYH9/MAPK3/PTPRS/PTPRF/LYN/ARPC1B/ARPC2/PAK2/MYL6/MAP2K1/ESAM/SRGAP2/F11R/ACTN4/PTK2/VAV2/SRGAP1/TUBA1C/NLGN4X/FOXO1/ACTR3/ARPC3/VCL/MAG/TRIO/RAP1A/RAC1/RAP1B/IQGAP1/ARPC1A/PIK3R1/PARD6G/CABLES1/MPDZ/ICAM3/MAPK13/CRTAM	3.96729372026076
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	24/886	116/9376	2.18946057445318	ACTG1/CLDN19/CD99/ACTB/JAM2/MMP2/PXN/ACTN1/PTK2B/ESAM/F11R/CLDN23/ACTN4/PTK2/VAV2/VCL/RAP1A/RAC1/RAP1B/CLDN4/CLDN3/VASP/PIK3R1/MAPK13	4.1641101293591
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/886	41/9376	3.09728569068986	TYMP/DAPK1/MMP2/MAPK3/CDKN1A/MAP2K1/VEGFA/E2F3/CDKN2A/ERBB2/FGFR3/MYC	4.3475142582515
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	27/886	142/9376	2.01214510539535	FHL2/FOSB/IFNGR2/TGFB1/JAK1/PPP3CA/SOCS3/TGFB2/MAPK3/STAT1/JUNB/MAP2K1/CSF1R/IFNAR2/FOSL1/FOS/FOSL2/ITPR3/IFNAR1/RAC1/IL1R1/IRF9/TNF/PIK3R1/RELB/PPP3CC/MAPK13	3.92591299235036
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	27/886	142/9376	2.01214510539535	ACTG1/CAV2/IL1R2/ACTB/SDC4/MMP2/TXN/DUSP1/PDGFB/GSTM3/PTK2/ARHGEF2/FOS/BMPR2/CALM3/CALM2/KLF2/SUMO2/RAC1/VEGFA/IL1R1/CAV1/SUMO3/BMPR1B/TNF/PIK3R1/MAPK13	3.92591299235036
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/886	109/9376	2.13589578975708	EBI3/IL1RAP/IFNGR2/IL2RB/TGFB1/JAK1/PPP3CA/MAPK3/STAT1/IL27RA/RUNX1/HIF1A/SMAD3/GATA3/FOS/RARA/IL1R1/STAT3/STAT6/RXRA/PPP3CC/MAPK13	3.85328215576752
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	21/886	103/9376	2.15757522628153	FN1/IL1R2/TGFB1/SERPINB9/ACTN1/TGFB2/LAMA3/COL4A2/LAMA4/ACTN4/PTK2/LAMB3/VCL/GNAQ/COL4A1/IL1R1/GNAL/CXCL2/TNF/PIK3R1/C9	3.81598237535742
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	46/886	300/9376	1.62263355906697	IL1RAP/FLT1/RASGRF2/TGFB1/FGFR1/IGF2/PPP3CA/FLNA/GADD45A/TGFB2/MAPK3/RRAS/DUSP1/DUSP4/MAP2K3/PAK2/MAP2K1/CSF1R/PDGFB/MAP3K8/FOS/EFNA1/RAP1A/AREG/RAC1/VEGFA/IL1R1/RAP1B/DUSP7/INSR/DAXX/FLT4/TNF/MAP3K6/TAOK3/DUSP10/RASGRF1/RELB/CRKL/RPS6KA1/MAP4K2/PPP3CC/ERBB2/FGFR3/MAPK13/MYC	3.54074428309769
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	28/886	157/9376	1.88730571810614	ACTG1/TGFB1/ACTB/WWTR1/TGFB2/TCF7L2/SERPINE1/SMAD3/WNT7A/LLGL2/PPP2R2B/YWHAZ/BMPR2/WTIP/AREG/ID1/TEAD4/YWHAG/SAV1/YWHAQ/TEAD1/BMPR1B/FZD8/PARD6G/APC/AXIN1/LIMD1/MYC	3.62184493865341
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	24/886	128/9376	1.98419864559819	PAPSS1/PDE4C/ADA/NME2/AK5/NME4/GUK1/NT5E/HDDC2/PGM2/ADK/PDE10A/PDE6H/AMPD2/PDE4A/AK1/ADCY7/GDA/PPAT/ADSL/AK4/ENTPD4/HPRT1/ITPA	3.6217001521593
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	33/886	200/9376	1.74609480812641	TNFSF10/ACTG1/CLDN19/TUBB2A/TUBB6/ACTB/MYH9/BAIAP2L1/WIPF1/MAPK3/SEC24D/ARPC1B/ARPC2/PAK2/TNFRSF10B/CLDN23/ARHGEF2/GAPDH/FOS/TUBA1C/ACTR3/ARPC3/CASP7/RAB1A/RAC1/IL1R1/CLDN4/CLDN3/ARPC1A/MYO1E/TNF/LPAR2/MAPK13	3.44533112265064
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/886	87/9376	2.18946057445318	TGFB1/GADD45A/TGFB2/RALB/TCF7L2/MAPK3/CDKN1A/MAP2K1/SMAD3/FOS/AREG/RAC1/RALA/PIK3R1/APC/RALGDS/AXIN1/MYC	3.60059148831748
NA	NA	hsa04382	Cornified envelope formation	35/886	217/9376	1.7068375446006	KRT19/COL17A1/S100A6/KRT8/CLDN19/S100A4/PKP2/PCSK6/LAMA3/SLC27A1/KRT18/S100A13/UGCG/KRT14/KRT17/KRT15/S100A16/COL4A2/KRT7/CLDN23/PPP2R2B/PPP2R5E/SPRR2G/LAMB3/COL4A1/PRSS8/PPL/KRT10/CLDN4/CLDN3/PPP2R3A/TCHH/PPP2R5A/SPTLC2/KRT78	3.40309521999817
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/886	36/9376	2.93955354903436	GALNT6/GALNT7/GALNT2/GALNT3/ST3GAL1/GCNT1/C1GALT1C1/B4GALT5/ST6GALNAC2/GALNT12	3.76641560735222
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	20/886	105/9376	2.01569386219499	PLK3/PPP3CA/IRF1/MAPK3/RRAS/STAT1/CBLB/BCL3/CALM3/CALM2/IL17D/ITPR3/IRF9/KSR1/TNF/PIK3R1/CLEC7A/RELB/PPP3CC/MAPK13	3.38098186312294
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	15/886	71/9376	2.23571678377261	LDHA/FGFR1/MAPK3/PKM/SLC16A3/PFKP/MAP2K1/HK2/HIF1A/SLC1A5/PIK3R1/PDK1/ERBB2/FGFR3/MYC	3.37628100209699
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/886	93/9376	2.04820505352072	FN1/GADD45A/LAMA3/BIRC7/CDKN1A/COL4A2/LAMA4/PTK2/ITGA2/ITGA3/LAMB3/COL4A1/RXRA/PIK3R1/TRAF4/E2F3/MYC/TRAF3	3.28164956279199
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	26/886	154/9376	1.78663774149101	RFK/MTHFD1L/UGDH/BCAT1/MTHFD2/NME2/AK5/VKORC1/NME4/ALDH2/CPOX/ALPP/SHMT1/NMNAT2/RDH13/PSAT1/CMPK1/ALDH1B1/AK1/ADSL/AK4/CTPS1/GCH1/ALAD/CTPS2/VKORC1L1	3.17959082234629
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/886	101/9376	1.99074715597971	FN1/TGFB1/MMP2/TGFB2/MAPK3/STAT1/SERPINE1/SMAD3/COL4A2/PLCD3/PIM1/FOXO1/COL4A1/RAC1/VEGFA/STAT3/TNF/PIK3R1/MAPK13	3.23381533452056
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/886	59/9376	2.33171366262387	TYMP/UPP1/UCK2/CDA/NME2/NME4/NT5E/HDDC2/DCTD/CMPK1/CTPS1/ENTPD4/CTPS2	3.314724722785
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/886	205/9376	1.65188570170126	TNFAIP3/ISG15/HLA-G/TAP1/JAK1/GADD45A/STAT1/HLA-E/LYN/CDKN1A/TAP2/TAPBP/B2M/MAP2K3/IFNAR2/NCOR2/OAS3/IFNAR1/RAC1/IRF9/STAT3/CD40/TNF/PIK3R1/E2F3/EIF2AK2/RELB/OAS2/OAS1/MAPK13/MYC/TRAF3	3.04851750585094
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	37/886	248/9376	1.57882472875555	TNFSF10/ACTG1/TUBB2A/TUBB6/RHOB/ACTB/PKN1/FLNA/TXN/TCF7L2/MAPK3/RRAS/ARPC1B/ARPC2/MAP2K3/MAP2K1/PFN2/TNFRSF10B/PFN1/GAPDH/FOS/TUBA1C/ACTR3/ARPC3/AHNAK2/RIPK2/CASP7/RAC1/SNX9/RALA/ARPC1A/ANXA2/DNM2/TNF/DYNC1LI1/MAPK13/MYC	2.9842400577803
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/886	89/9376	2.02135592360565	FN1/ITGA5/HSPG2/SDC4/LAMA3/ITGA1/AGRN/COL4A2/LAMA4/ITGA2/ITGA3/LAMB3/COL4A1/SV2A/GP6/ITGB6/THBS3	3.12739722599247
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	11/886	49/9376	2.37563919472981	GALNT6/GALNT7/GALNT2/GALNT3/PLOD3/COLGALT1/C1GALT1C1/B4GALT2/POFUT2/GALNT12/B4GALT3	3.11874773029375
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	22/886	133/9376	1.75047098559039	TNFSF10/TGFB1/PLK3/GADD45A/TGFB2/MAPK3/HOMER3/GABARAP/CDKN1A/MAP2K1/PLK2/SMAD3/CCNG2/FOXO1/PRKAG2/KLF2/SOD2/STAT3/INSR/RBL2/PIK3R1/MAPK13	2.81580064690007
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	19/886	110/9376	1.82786784321773	ID3/TGFB1/NOG/INHBA/SKIL/TGIF1/TGFB2/LRRC32/MAPK3/BAMBI/EMP3/SMAD3/ID4/BMPR2/ID1/BMPR1B/TNF/LTBP1/MYC	2.82136881902589
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/886	14/9376	3.77942599161561	B3GNT7/ST3GAL1/B4GALT2/B4GALT3/B4GALT4	3.36188975680906
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/886	119/9376	1.77855340781911	TNFAIP3/SOCS3/IRF1/MAPK3/JUNB/BCL3/MAP2K3/MAP2K1/MAP3K8/FOS/CASP7/CREB3L2/DAB2IP/CXCL2/TNF/PIK3R1/CEBPB/MAPK13/TRAF3/RHBDF1	2.76105725703785
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	26/886	168/9376	1.63775126303343	CSH1/CSF2RB/IFNGR2/IL2RB/JAK1/SOCS3/STAT1/CDKN1A/IL27RA/PDGFB/IL13RA1/IL10RA/IFNAR2/OSMR/EPOR/LEP/PIM1/IFNAR1/STAT4/IL11/IRF9/STAT3/STAT6/PIK3R1/GH2/MYC	2.69446140336545
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/886	144/9376	1.69024329069476	ID3/KLF4/INHBA/FGFR1/JAK1/SKIL/MAPK3/MAP2K1/SMAD3/ID4/WNT7A/BMI1/BMPR2/ID1/STAT3/BMPR1B/FZD8/PIK3R1/APC/AXIN1/FGFR3/MAPK13/MYC	2.69639924004118
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	25/886	163/9376	1.62306637676744	HSPG2/TGFB1/JAK1/TGFB2/MAPK3/STAT1/CDKN1A/MAP2K3/PTK2B/MAP2K1/SMAD3/YWHAZ/FOS/IFNAR1/STAT4/STAT3/CREB3L2/STAT6/YWHAQ/TNF/PIK3R1/E2F3/MAPK13/MYC/TRAF3	2.59224613848283
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/886	224/9376	1.51177039664624	HLA-G/IL2RB/IL1R2/TGFB1/TSPO/JAK1/PPP3CA/TGFB2/MAPK3/HLA-E/ZFP36/CDKN1A/B2M/MAP2K1/SMAD3/FOSL1/FOS/TLN2/ETS2/IL1R1/CRTC3/CD40/CREB3L2/ADCY7/TNF/PIK3R1/E2F3/CDKN2A/RELB/PPP3CC/CDC26/MYC	2.50431997749364
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	26/886	173/9376	1.59041741150067	TNFSF10/ACTG1/IFNGR2/ACTB/JAK1/SOCS3/MAPK3/STAT1/MX1/MAP2K1/IFNAR2/TNFRSF10B/OAS3/ADAR/IFNAR1/TRIM25/IRF9/NXT1/HNRNPUL1/TNF/MX2/PIK3R1/EIF2AK2/OAS2/OAS1/TRAF3	2.53201428181192
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/886	77/9376	1.9240714139134	TGFB1/CTBP2/GADD45A/TGFB2/MAPK3/CDKN1A/RUNX1/MAP2K1/SMAD3/PIK3R1/E2F3/CDKN2A/CRKL/MYC	2.6301555165643
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/886	109/9376	1.74755110071034	PPP1R3B/PYGL/SOCS3/PTPRF/MLXIP/SLC27A1/SLC27A6/GYS1/FOXO1/PRKAG2/STAT3/CPT1A/CREB3L2/INSR/TNF/PIK3R1/TRIB3/RPS6KA1	2.53590632421266
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	33/886	238/9376	1.46730656145077	FLT1/RASGRF2/FGFR1/REL/TIAM1/IGF2/RALB/MAPK3/RRAS/PAK2/GNB1/MAP2K1/CSF1R/PDGFB/GNB5/PLA2G10/CALM3/CALM2/ETS2/EFNA1/RAP1A/RAC1/VEGFA/RAP1B/GNG10/RALA/INSR/FLT4/KSR1/PIK3R1/RASGRF1/RALGDS/FGFR3	2.35892120656206
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/886	178/9376	1.5457427651102	SFRP1/CTBP2/PPP3CA/GPC4/TCF7L2/BAMBI/APCDD1/SMAD3/WNT7A/FOSL1/ANKRD6/TLE6/CTNND2/RAC1/PORCN/NOTUM/CACYBP/FZD8/APC/TLE2/PPP3CC/FRAT2/AXIN1/CELSR1/CSNK2B/MYC	2.37465181313068
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/886	50/9376	2.11647855530474	AOC1/P4HA1/PYCR1/P4HA2/ALDH2/OAT/AMD1/SRM/ALDH1B1/ODC1	2.5570330208822
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/886	137/9376	1.62211860078101	TNFSF10/CTSH/ACTG1/CSF2RB/ACTB/GADD45A/MAPK3/MAP2K1/CTSZ/ENDOG/TNFRSF10B/CAPN2/FOS/TUBA1C/ITPR3/CASP7/CTSB/DAB2IP/DAXX/TNF/PIK3R1	2.3695705334817
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/886	214/9376	1.48351300605472	HLA-G/TAP1/PXN/PPP3CA/MAPK3/HLA-E/TAP2/TAPBP/B2M/MAP2K3/PAK2/GNB1/PTK2B/MAP2K1/GNB5/PTK2/LIMK1/FOS/BST2/CALM3/CALM2/ITPR3/GNAQ/RAC1/GNG10/TNF/PIK3R1/CRKL/PPP3CC/MAPK13	2.31136513314044
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	26/886	180/9376	1.52856784549787	ITGA5/HLA-G/IFNGR2/TAP1/JAK1/EIF4EBP1/SOCS3/STAT1/HLA-E/TAP2/TAPBP/B2M/IFNAR2/SP100/BST2/OAS3/IFNAR1/IRF9/DAXX/TNF/PIK3R1/EIF2AK2/OAS2/OAS1/ZC3HAV1/TRAF3	2.31305609580484
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	21/886	138/9376	1.61036411816665	PPP1R3B/PYGL/EIF4EBP1/SOCS3/MAPK3/PTPRF/CBLB/MAP2K1/HK2/EIF4E/GYS1/TRIP10/CALM3/CALM2/FOXO1/PRKAG2/PRKAR2A/FLOT1/INSR/PIK3R1/CRKL	2.33339473089582
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/886	44/9376	2.16458034065258	KRTCAP2/MGAT4A/MAN2A1/MGAT2/HEXB/B4GALT2/MGAT1/B4GALT3/ALG9	2.50124988506234
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	19/886	122/9376	1.64807756355697	EIF4EBP1/PFKP/SCD/GYS1/PPP2R2B/PPP2R5E/LEP/FOXO1/PRKAG2/RAB2A/CPT1A/PPP2R3A/CREB3L2/PPP2R5A/INSR/ADIPOR1/PIK3R1/TBC1D1/PFKFB3	2.32750599468748
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/886	122/9376	1.64807756355697	CSH1/IGFBP3/SOCS3/MAPK3/STAT1/JUNB/MAP2K3/MAP2K1/PTK2/FOS/ITPR3/GNAQ/STAT3/CREB3L2/ADCY7/PIK3R1/CRKL/GH2/MAPK13	2.32750599468748
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/886	37/9376	2.28808492465377	UGDH/HK2/GALK1/PGM3/GALE/NANS/PGM2/UAP1	2.53596833078227
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/886	37/9376	2.28808492465377	GADD45A/TCF7L2/MAPK3/CDKN1A/MAP2K1/TPM3/RXRA/MYC	2.53596833078227
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	30/886	216/9376	1.46977677451718	TNFSF10/XBP1/PPP3CA/ERO1A/MAPK3/LYN/MAP2K3/HSPA2/TNFRSF10B/PTK2/VAV2/FOS/ABCA1/CALM3/CALM2/SOD2/CASP7/RAP1A/RAC1/RAP1B/VLDLR/STAT3/CD40/CXCL2/RXRA/TNF/PIK3R1/PPP3CC/MAPK13/TRAF3	2.2564168514362
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/886	90/9376	1.76373212942062	IFNGR2/JAK1/PPP3CA/MAPK3/STAT1/BATF3/MAP2K3/MAP2K1/HIF1A/FOS/STAT3/PIK3R1/PPP3CC/MAPK13/CSNK2B	2.35177966242664
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/886	67/9376	1.89535393012365	LDHA/ALDOA/PKM/PFKP/ENO1/HK2/ALDH2/GAPDH/TPI1/PGK1/PGM2/ALDH1B1	2.37590616524951
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/886	67/9376	1.89535393012365	PPP3CA/MAPK3/MAP2K1/CALM3/CALM2/ITPR3/GNAQ/RAP1A/RAP1B/RPS6KA1/PPP3CC/GRIN2D	2.37590616524951
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	34/886	253/9376	1.4221397407186	ITGA5/ACTG1/ACTB/PXN/ACTN1/MAPK3/ARPC1B/ARPC2/HK2/PFN2/PLCD3/CAPN2/ACTN4/PTK2/PFN1/ARHGEF2/TLN2/FOXO1/ACTR3/ARPC3/ITPR3/VCL/RIPK2/RAC1/FNBP1/IL1R1/ARPC1A/UBE2D1/TECPR1/UBE2V1/TNF/PIK3R1/CRKL/MAPK13	2.19885360660328
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/886	75/9376	1.83428141459744	ALDOA/PYCR1/PKM/BCAT1/PFKP/ENO1/GAPDH/TPI1/PGK1/SHMT1/PHGDH/PSAT1/ASNS	2.34329535898048
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/886	38/9376	2.22787216347867	UGDH/HK2/GALK1/HEXB/PGM3/GALE/PGM2/UAP1	2.45000331121291
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/886	60/9376	1.94010534236268	PXN/PPP3CA/MAPK3/MAP2K1/SPHK1/PTK2/RAC1/VEGFA/PIK3R1/PPP3CC/MAPK13	2.35985902721944
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/886	68/9376	1.86748107821007	EIF4EBP1/TCF7L2/MAPK3/RUNX1/MAP2K1/CSF1R/PIM1/RARA/STAT3/PIK3R1/PER2/MYC	2.31918254474651
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/886	32/9376	2.31489841986456	PFKP/HK2/GALK1/GALE/PGM2/B4GALT2/GAA	2.40685225451942
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/886	62/9376	1.87752129906066	CTBP2/APH1B/NOTCH2/ATXN1/DTX3L/MAML2/NCOR2/TLE6/DTX4/HEY1/TLE2	2.23941224389404
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/886	78/9376	1.76373212942062	ITGA5/SERPING1/IRF1/MAPK3/FOS/CALM3/CALM2/C1S/CASP7/IRF8/TNF/MAPK13/C2	2.1879744475728
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/886	136/9376	1.55623423184172	TNFAIP3/IL2RB/JAK1/STAT1/MX1/CBLB/IFNAR2/FOS/OAS3/ADAR/IFNAR1/IRF9/STAT3/MX2/PIK3R1/EIF2AK2/OAS2/OAS1/CSNK2B/TRAF3	2.11076476242082
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/886	55/9376	1.9240714139134	PLPP2/GM2A/UGCG/SPHK1/HEXB/B4GALT5/SGPP1/SPTLC2/CERS5/CERS6	2.22026227791964
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/886	63/9376	1.84771937367874	PLOD2/PLOD3/PIPOX/SMYD3/COLGALT1/ALDH2/AADAT/ALDH1B1/SMYD2/SUV39H1/TMLHE	2.18085221076431
NA	NA	hsa03272	Virion - Hepatitis viruses	9/886	48/9376	1.98419864559819	HSPG2/CD9/CLDN19/SCARB1/CLDN23/DPP4/CLDN4/CLDN3/CD63	2.20829844708252
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	18/886	122/9376	1.56133663915923	DIO2/ACTG1/ACTB/MAPK3/STAT1/MED13L/PFKP/MAP2K1/HIF1A/NOTCH2/PLCD3/THRB/FOXO1/ATP1B1/RXRA/PIK3R1/ATP1A1/MYC	2.01598460762944
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	22/886	157/9376	1.48288306422625	TGFB1/ATP11A/MAPK3/ADAM9/SLC16A1/DUSP4/MAP2K1/HIF1A/SPHK1/EPOR/PTK2/ABCA1/CASP7/ADAM10/RAC1/CPT1A/DUSP7/RXRA/ODC1/CRKL/CEBPB/MAPK13	1.97105410958266
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	25/886	184/9376	1.43782510550594	EFNB1/PPP3CA/SEMA5A/MAPK3/RRAS/EPHB2/RHOD/SEMA4C/PAK2/SRGAP2/SEMA4A/PTK2/LIMK1/SRGAP1/BMPR2/EFNA1/RAC1/ENAH/SSH2/SEMA3B/BMPR1B/PIK3R1/PARD6G/EPHB3/PPP3CC	1.93755133865246
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/886	107/9376	1.58241387312504	LDHA/PYGL/PPP3CA/PKM/PFKP/SIK1/GYS1/CALM3/CALM2/FOXO1/PRKAG2/ITPR3/GNAQ/CPT1A/CREB3L2/PPP3CC	1.95729286578276
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	15/886	99/9376	1.60339284492783	PLPP2/EIF4EBP1/MAPK3/MAP2K1/HIF1A/PDGFB/SLC44A2/LYPLA1/FOS/RAC1/CHKB/PIP5K1C/PIK3R1/DGKZ/RALGDS	1.94967682302185
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/886	99/9376	1.60339284492783	TPM1/ITGA5/ACTG1/TGFB1/ACTB/TGFB2/ITGA1/TPM4/TPM3/TPM2/ITGA2/ITGA3/PRKAG2/TNF/ITGB6	1.94967682302185
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/886	160/9376	1.45507900677201	CLDN19/HLA-G/CD99/CD276/JAM2/PVR/SDC4/PTPRS/HLA-E/PTPRF/ESAM/F11R/PDCD1LG2/CLDN23/NLGN4X/MAG/CLDN4/CLDN3/CD40/VCAN/CD22/ICAM3	1.87553085753745
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/886	15/9376	2.82197140707299	ST3GAL1/ST3GAL5/HEXB/ST6GALNAC6	2.28125964547871
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/886	15/9376	2.82197140707299	AK5/ALPP/AK1/AK4	2.28125964547871
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	32/886	250/9376	1.35454627539503	CAV2/HLA-G/IL2RB/WIPF1/ASAP3/HLA-E/CLTB/ARPC1B/CBLB/ARPC2/SMAD3/IQSEC1/SH3GL1/ACTR3/EHD4/ARPC3/ASAP2/CAV1/VPS37B/ASAP1/ARPC1A/DNM2/RAB22A/SMAP1/PIP5K1C/PARD6G/EPN2/CAPZA1/ARAP2/CBLC/VPS37C/FGFR3	1.8354871714658
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	25/886	187/9376	1.41475839258338	TNFAIP3/JAK1/PKN1/GBP2/TXN/MAPK3/STAT1/GABARAP/GBP1/IFNAR2/OAS3/ANTXR1/ITPR3/RIPK2/IFNAR1/GBP3/NAMPT/CTSB/IRF9/CXCL2/TNF/OAS2/OAS1/MAPK13/TRAF3	1.85067651663619
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/886	59/9376	1.79362589432605	GADD45A/TCF7L2/MAPK3/CDKN1A/MAP2K1/PIK3R1/APC/AXIN1/ERBB2/MYC	1.97538813815408
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/886	109/9376	1.55337875618697	JAK1/MAPK3/STAT1/MAP2K3/MAP2K1/MAP3K8/IFNAR2/FOS/IFNAR1/RAC1/IRF9/CD40/TNF/PIK3R1/MAPK13/TRAF3	1.87721840843523
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/886	29/9376	2.18946057445318	WWTR1/WTIP/TEAD4/SAV1/TEAD1/LIMD1	2.07234273641309
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	37/886	298/9376	1.31392125077643	CSH1/EBI3/IL1RAP/TNFSF10/CSF2RB/IFNGR2/IL2RB/IL1R2/INHA/TGFB1/INHBA/TNFRSF12A/TGFB2/GDF15/ACVRL1/IL27RA/CSF1R/IL13RA1/IL10RA/IFNAR2/TNFRSF10B/OSMR/EPOR/LEP/XCR1/CCR1/BMPR2/ACKR3/IL17D/IFNAR1/IL1R1/IL11/CD40/CXCL2/BMPR1B/TNF/GH2	1.77902648220687
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	14/886	93/9376	1.59304837496056	IFNGR2/IL2RB/JAK1/PPP3CA/MAPK3/STAT1/NOTCH2/MAML2/GATA3/FOS/STAT4/STAT6/PPP3CC/MAPK13	1.85667578482567
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	21/886	155/9376	1.4337435374645	SCARB1/TCF7L2/HSD3B1/MAPK3/CDKN1A/MAP2K1/POMC/WNT7A/ITPR3/GNAQ/RAP1A/RAP1B/NCEH1/CREB3L2/CRH/ADCY7/FZD8/APC/E2F3/CDKN2A/AXIN1	1.7589703108889
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	26/886	201/9376	1.36886672731152	IGFBP3/FLT1/IL2RB/IL1R2/NFKBIZ/NR4A3/REL/GADD45A/ARNT2/HPGD/CDKN1A/RUNX1/CSF1R/BMI1/PTK2/FOXO1/RARA/BMP2K/PLAU/CD40/MLF1/RXRA/PER2/MYCN/CEBPB/MYC	1.70770609641212
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	16/886	112/9376	1.51177039664624	IFNGR2/TGFB1/JAK1/TGFB2/LAMA3/MAPK3/STAT1/BIRC7/MAP2K3/IL10RA/LAMA4/LAMB3/STAT3/CD40/TNF/MAPK13	1.76008463900282
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	19/886	139/9376	1.44651412053202	KRT19/MMP2/MAPK3/KRT18/KRT14/KRT17/MAP2K1/POMC/KRT15/FOS/CALM3/CALM2/ITPR3/GNAQ/RARA/KRT10/CREB3L2/ADCY7/PIK3R1	1.71326988001813
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/886	54/9376	1.76373212942062	LDHA/BCAT1/AMD1/ENOPH1/SRM/MPST/PHGDH/PSAT1/MTAP	1.81815977811898
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	15/886	105/9376	1.51177039664624	TPM1/ITGA5/ACTG1/TGFB1/ACTB/TGFB2/ITGA1/TPM4/TPM3/TPM2/ITGA2/ITGA3/ADCY7/TNF/ITGB6	1.70355113242971
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/886	133/9376	1.43220353366486	PPP3CA/GNB1/GNB5/PPP2R2B/PPP2R5E/FOS/CALM3/CALM2/ITPR3/TH/GNAQ/GNAL/GNG10/PPP2R3A/CREB3L2/PPP2R5A/PPP3CC/MAPK13	1.62164695644911
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/886	98/9376	1.51177039664624	SCARB1/HSD3B1/PRKD3/POMC/CALM3/CALM2/ATP1B1/ITPR3/GNAQ/NR4A2/CREB3L2/ADCY7/DAGLB/ATP1A1	1.64516578315788
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/886	56/9376	1.70074169622702	KRTCAP2/MGAT5/MGAT4A/MAN2A1/MGAT2/B4GALT2/MGAT1/B4GALT3/ALG9	1.69899723243845
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	16/886	116/9376	1.45964038296879	ALDOA/PKM/PFKP/ENO1/HK2/GAPDH/TPI1/PGK1/SHMT1/PHGDH/H6PD/PSAT1/AGXT/ACOX1/MCEE/GLUD1	1.60912704102254
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/886	99/9376	1.49649998859931	MMP2/MAPK3/CDKN1A/MAP2K1/NOTCH2/PTK2/FOS/CARM1/ADCY7/PIK3R1/E2F3/CDKN2A/ERBB2/MAPK13	1.60428571293129
Organismal Systems	Immune system	hsa04611	Platelet activation	17/886	126/9376	1.42778315238812	ACTG1/ACTB/MAPK3/LYN/ITGA2/APBB1IP/TLN2/ITPR3/GNAQ/RAP1A/RAP1B/SNAP23/VASP/GP6/ADCY7/PIK3R1/MAPK13	1.56166089972044
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/886	66/9376	1.60339284492783	IFNGR2/TGFB1/TGFB2/STAT1/SMAD3/GATA3/STAT4/STAT3/STAT6/TNF	1.58908064242872
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/886	42/9376	1.76373212942062	FTH1/SLC39A8/PRNP/ACSL4/SLC39A14/SLC11A2/PCBP1	1.60243514798651
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/886	76/9376	1.53166211239159	ACTG1/ACTB/CA2/CALM3/CALM2/ATP1B1/ITPR3/KCNJ15/GNAQ/ADCY7/ATP1A1	1.50331395292472
Cellular Processes	Cell motility	hsa04814	Motor proteins	24/886	194/9376	1.309161992972	TPM1/ACTG1/TUBB2A/TUBB6/ACTB/MYH9/TNNI2/MYL6/TPM4/TPM3/KIF21A/MYO7B/TPM2/DNAH11/TUBA1C/KIF12/KIF3C/KIF1B/KIF3A/MYO1E/KIF13A/DYNC1LI1/CAPZA1/TUBG1	1.40561690940066
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	19/886	148/9376	1.35855042401318	FGFR1/GADD45A/TCF7L2/MAPK3/CDKN1A/MAP2K1/NOTCH2/WNT7A/FOS/FLT4/FZD8/HEY1/PIK3R1/APC/E2F3/FRAT2/AXIN1/ERBB2/MYC	1.42028650057103
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/886	51/9376	1.65998318063117	LPCAT1/PLPP2/PLA2G7/GDPD3/PLA2G10/LPCAT2/PAFAH1B2/LPCAT4	1.52665951812592
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/886	35/9376	1.81412447597549	ALDOA/PFKP/HK2/TPI1/SORD/PFKFB3	1.55875120348583
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/886	86/9376	1.47661294556145	EIF4EBP1/MAPK3/CDKN1A/CBLB/PAK2/MAP2K1/PTK2/AREG/PIK3R1/CRKL/ERBB2/MYC	1.43435237529136
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/886	205/9376	1.29053570445411	HLA-G/REL/JAK1/PXN/ACTN1/MAPK3/PKM/HLA-E/LYN/CDKN1A/GSN/ACTN4/SP100/YWHAZ/RAC1/IRF9/STAT3/YWHAG/CREB3L2/YWHAQ/RBL2/PIK3R1/EIF2AK2/CDKN2A/TRAF3	1.35867864380462
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/886	122/9376	1.38785479036376	PPP3CA/MAPK3/CBLB/PAK2/MAP2K1/MAP3K8/PPP2R2B/PPP2R5E/VAV2/FOS/PPP2R3A/PPP2R5A/TNF/PIK3R1/PPP3CC/MAPK13	1.39294183351336
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/886	20/9376	2.11647855530474	UGDH/CYB5R2/NANS/UAP1	1.61461480765736
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/886	78/9376	1.49238872489437	IFNGR2/TGFB1/JAK1/TGFB2/MAPK3/STAT1/EEF1A1/MARCKSL1/FOS/TNF/MAPK13	1.41061755403576
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/886	61/9376	1.56133663915923	FTH1/MT1X/MT1F/SLC39A4/MT1E/ATP1B1/MT1H/SLC11A2/ATP1A1	1.42084116792891
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/886	36/9376	1.76373212942062	PYGL/HK2/GYS1/PGM2/GYG1/GAA	1.48309007169113
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/886	70/9376	1.51177039664624	SOCS3/POMC/LEP/ACSL4/PRKAG2/STAT3/CPT1A/RXRA/TNF/ADIPOR1	1.38832553143116
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	21/886	170/9376	1.30723675474705	ACTG1/TGFB1/ACTB/IGF2/GADD45A/TGFB2/TCF7L2/MAPK3/CDKN1A/MAP2K1/SMAD3/WNT7A/GSTM3/FZD8/PIK3R1/APC/E2F3/CDKN2A/FRAT2/AXIN1/MYC	1.30590263616409
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	17/886	133/9376	1.35263667068348	TNFSF10/HLA-G/IFNGR2/PPP3CA/MAPK3/HLA-E/PTK2B/MAP2K1/IFNAR2/TNFRSF10B/VAV2/IFNAR1/RAC1/KLRD1/TNF/PIK3R1/PPP3CC	1.32310853383637
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/886	115/9376	1.3803121012857	FGFR1/MAPK3/CDKN1A/PDE4C/MAP2K1/GATA3/FOS/ITPR3/GNAQ/NR4A2/CREB3L2/PDE4A/ADCY7/RXRA/PTH1R	1.32558864939788
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/886	88/9376	1.44305356043505	SERPINE2/PROCR/SERPING1/TFPI/PLAUR/SERPINE1/CLU/C1S/PLAU/CFB/C9/C2	1.34891665739538
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/886	106/9376	1.39767451765407	IL1R2/FGFR1/TCF7L2/MAPK3/CDKN1A/MAP2K1/PDGFB/FOXO1/NKX3-1/PLAU/CREB3L2/PIK3R1/E2F3/ERBB2	1.33011589260165
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/886	71/9376	1.49047785584841	SOCS3/IRF1/MAPK3/STAT1/MAP2K1/FOS/TH/STAT3/PIK3R1/MAPK13	1.3401056685453
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/886	125/9376	1.35454627539503	MAPK3/MAP2K1/SPHK1/PPP2R2B/PPP2R5E/GNAQ/RAC1/SGPP1/PPP2R3A/PPP2R5A/SPTLC2/TNF/PIK3R1/CERS5/CERS6/MAPK13	1.28908705546296
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/886	21/9376	2.01569386219499	DSE/CSGALNACT2/CSGALNACT1/CHST3	1.50521741203408
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	22/886	181/9376	1.28625768554432	IFNGR2/TGFB1/PLK3/JAK1/PPP3CA/TGFB2/MAPK3/STAT1/MRC2/IL10RA/SPHK1/CALM3/CALM2/RIPK2/KSR1/TNF/CLEC7A/CEBPB/CORO1A/CEBPG/PPP3CC/MAPK13	1.25623020158893
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/886	80/9376	1.45507900677201	JAK1/EIF4EBP1/MAPK3/MAP2K1/PDGFB/EIF4E/VEGFA/STAT3/PIK3R1/ERBB2/FGFR3	1.32048171418234
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/886	155/9376	1.29719653389645	ITGA5/ACTG1/HLA-G/TUBB2A/TAP1/TUBB6/ACTB/SCARB1/HLA-E/MRC2/TAP2/ITGA2/TUBA1C/RAC1/SEC61G/CLEC7A/DYNC1LI1/THBS3/CORO1A	1.20522805406809
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	23/886	193/9376	1.26111416507795	PXN/TIAM1/MAPK3/STAT1/LYN/GNB1/PTK2B/MAP2K1/GNB5/PTK2/VAV2/XCR1/CCR1/GNAQ/RAP1A/RAC1/RAP1B/STAT3/GNG10/CXCL2/ADCY7/PIK3R1/CRKL	1.18403747661758
Genetic Information Processing	Translation	hsa03010	Ribosome	26/886	222/9376	1.23937933418746	RPS26/RPS4Y1/RPL17/RPL41/RPS27L/RPL36A/RPL4/MRPL23/RPS10/RPL37/RPL23A/RPL37A/RPL38/RPLP0/RPS29/RPL23/RPS20/RPS11/MRPL53/MRPL28/MRPS9/RPL21/MRPL52/RPL13A/RPL31/MRPL39	1.16602091884004
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/886	73/9376	1.44964284609914	GADD45A/MAPK3/CDKN1A/MAP2K1/STAT3/RXRA/PIK3R1/E2F3/CDKN2A/ERBB2	1.24585144916533
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/886	91/9376	1.39548036613499	DAPP1/PPP3CA/MAPK3/LYN/MAP2K1/VAV2/FOS/RAC1/CD22/PIK3R1/PIK3AP1/PPP3CC	1.22462557140634
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/886	22/9376	1.9240714139134	AOC1/ALDH2/ALDH1B1/CARNMT1	1.40173800112997
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/886	47/9376	1.57610105182268	SOCS3/MAPK3/PKM/HK2/INSR/TNF/PIK3R1	1.27902403182436
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	17/886	138/9376	1.30362809565872	PPP3CA/MAPK3/MAP2K1/PPP2R5E/YWHAZ/CALM3/CALM2/ITPR3/YWHAG/PPP2R5A/YWHAQ/ADCY7/MAD2L2/RPS6KA1/PPP3CC/MAPK13/CDC26	1.16075663276218
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/886	130/9376	1.30244834172599	TGFB1/MMP2/MAPK3/GNB1/MAP2K1/COL4A2/GNB5/EDNRB/FOS/COL4A1/VEGFA/GNG10/CREB3L2/ADCY7/PIK3R1/MAPK13	1.1217461646321
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/886	149/9376	1.27840986562031	PLPP2/RALB/MAPK3/RRAS/PTK2B/MAP2K1/PDGFB/SPHK1/RALA/DNM2/INSR/ADCY7/PIP5K1C/PIK3R1/AGPAT2/DGKZ/LPAR2/RALGDS	1.10661397033284
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/886	23/9376	1.8404161350476	CA2/ATP1B1/ATP1A1/GLUD1	1.30356138388197
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	26/886	226/9376	1.21744341676821	TIAM1/MAPK3/RRAS/PDE4C/MAP2K1/HCAR2/POMC/PTGER3/VAV2/FOS/CALM3/CALM2/ATP1B1/PDE10A/RAP1A/HCAR1/RAC1/RAP1B/CREB3L2/PDE4A/CRH/ADCY7/ACOX1/PIK3R1/ATP1A1/GRIN2D	1.06890372425068
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/886	103/9376	1.33564180674571	COL17A1/COL27A1/COL5A1/COL4A2/SLC1A5/DPP4/PRCP/ATP1B1/COL4A1/COL11A1/COL12A1/ATP1A1/SLC36A4	1.1064535504004
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/886	150/9376	1.26988713318284	TGFB1/GADD45A/TGFB2/TCF7L2/MAPK3/CDKN1A/MAP2K1/SMAD3/WNT7A/RXRA/FZD8/PIK3R1/APC/E2F3/FRAT2/AXIN1/ERBB2/MYC	1.07639020863478
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/886	94/9376	1.35094375870515	TNFAIP3/FOSB/MAPK3/FOSL1/FOS/IL17D/CXCL2/TNF/TRAF4/CEBPB/MAPK13/TRAF3	1.10466176417058
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/886	76/9376	1.39242010217417	PLIN2/ANGPTL4/SLC27A1/SCD/SLC27A6/ACSL4/FABP7/CPT1A/ACOX1/RXRA	1.10959686849393
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/886	76/9376	1.39242010217417	GADD45A/MAPK3/CDKN1A/MAP2K1/PDGFB/CALM3/CALM2/PIK3R1/E2F3/CDKN2A	1.10959686849393
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/886	16/9376	1.98419864559819	ST3GAL1/HEXB/NAGA	1.2727804152152
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	10/886	78/9376	1.35671702263124	PABPC1/PFKP/ENO1/TOB2/CNOT8/EXOSC5/TOB1/CNOT7/ZCCHC7/EXOSC1	1.02193910726724
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/886	69/9376	1.3803121012857	MAPK3/LYN/MAP2K3/MAP2K1/VAV2/RAC1/TNF/PIK3R1/MAPK13	1.02425593005926
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/886	69/9376	1.3803121012857	FOSB/PPP3CA/FOS/CALM3/CALM2/TH/CREB3L2/PPP3CC/GRIN2D	1.02425593005926
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/886	97/9376	1.309161992972	MAPK3/GNB1/GNB5/FOS/CALM3/CALM2/ITPR3/GNAQ/GNG10/ADCY7/PER2/GRIN2D	0.988712516397055
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/886	34/9376	1.55623423184172	BHLHE40/PRKAG2/NFIL3/PER2/CRY1	1.04960500711216
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/886	43/9376	1.47661294556145	PLPP2/SCARB1/SLC27A1/PLA2G10/ABCA1/AGPAT2	1.01190113536513
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/886	52/9376	1.42455287376281	TSPO/ANGPTL4/SCARB1/NPC2/ABCA1/NCEH1/SOAT1	0.991701518764323
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/886	62/9376	1.36547003568048	FOXO1/PRKAG2/SOD2/INSR/ADCY7/CRYAB/EIF4EBP2/PIK3R1	0.932670322139589
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/886	100/9376	1.26988713318284	ITGA5/CD9/IL1R2/ITGA1/CSF1R/EPOR/ITGA2/ITGA3/IL1R1/IL11/TNF/CD22	0.876497060983794
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/886	10/9376	2.11647855530474	PAPSS1/MPST	1.14109542223334
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/886	101/9376	1.25731399325034	TCF7L2/MAPK3/MAP2K1/POMC/WNT7A/EDNRB/CALM3/CALM2/GNAQ/CREB3L2/ADCY7/FZD8	0.83987718979303
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/886	82/9376	1.29053570445411	TYMP/UPP1/UCK2/CDA/NME2/NME4/GSTM3/CMPK1/HPRT1/ITPA	0.853598724321048
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/886	82/9376	1.29053570445411	HLA-G/TAP1/HLA-E/TAP2/TAPBP/B2M/HSPA2/CTSB/KLRD1/TNF	0.853598724321048
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	16/886	140/9376	1.20941631731699	MAPK3/RRAS/SERPINE1/GNB1/MAP2K1/SMAD3/GNB5/SPHK1/CALM3/CALM2/PRKAG2/KLF2/ITPR3/GNAQ/GNG10/ADCY7	0.806457022051891
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/886	73/9376	1.30467856148922	FGFR1/GADD45A/MAPK3/CDKN1A/MAP2K1/PDGFB/PIK3R1/E2F3/CDKN2A	0.844190518439309
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/886	102/9376	1.24498738547338	CA2/PLA2G10/ATP1B1/ITPR3/GNAQ/RAP1A/RAC1/RAP1B/RAB27B/ADCY7/ATP1A1/BST1	0.803635137093469
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/886	93/9376	1.25168086604044	MMP2/MAPK3/MAP2K3/PTK2B/MAP2K1/CALM3/CALM2/ITPR3/GNAQ/ADCY7/MAPK13	0.787945451350935
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/886	103/9376	1.23290012930373	IFNGR2/TGFB1/TGFB2/MAPK3/SERPINE1/PPP2R2B/FOS/GNAQ/GNAL/TNF/PIK3R1/MAPK13	0.767762447280777
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/886	37/9376	1.43005307790861	ASNS/AGXT/PPAT/ADSL/GLUD1	0.846684069705122
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/886	65/9376	1.30244834172599	SCARB1/HSD3B1/POMC/ITPR3/GNAQ/NCEH1/CREB3L2/ADCY7	0.790420829980606
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/886	28/9376	1.51177039664624	CBR1/TH/ALPP/GCH1	0.876079419831956
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/886	75/9376	1.26988713318284	IGFBP3/GADD45A/CDKN1A/SERPINE1/TNFRSF10B/CCNG2/EI24/ZMAT3/CDKN2A	0.758047890760056
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/886	154/9376	1.16818621559028	TPM1/MAPK3/TPM4/TPM3/PPP2R2B/PPP2R5E/TPM2/CALM3/CALM2/ATP1B1/GNAQ/PPP2R3A/CREB3L2/PPP2R5A/ADCY7/ATP1A1/MAPK13	0.679808912451111
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/886	105/9376	1.20941631731699	TNFAIP3/GADD45A/LYN/PLAU/IL1R1/TRIM25/CD40/CXCL2/TNF/RELB/CSNK2B/TRAF3	0.697092694013769
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/886	38/9376	1.39242010217417	MAPK3/ATP1B1/INSR/PIK3R1/ATP1A1	0.783005412378929
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/886	116/9376	1.18595781116214	PPP3CA/SLC1A6/MAPK3/HOMER3/GNB1/GNB5/SLC17A8/ITPR3/GNAQ/GNG10/ADCY7/PPP3CC/GRIN2D	0.651008382896335
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	40/886	388/9376	1.09096832747667	TUBB2A/TUBB6/NDUFA7/XBP1/SLC39A6/PPP3CA/MAPK3/SLC39A4/APH1B/RTN4/SLC39A8/MAP2K1/WNT7A/CAPN2/GAPDH/CALM3/CHRM5/TUBA1C/CALM2/SLC39A13/SLC39A14/ITPR3/GNAQ/PSMD9/CASP7/ADAM10/SLC11A2/INSR/SLC39A9/FZD8/TNF/PIK3R1/APC/EIF2AK2/PPP3CC/FRAT2/AXIN1/GRIN2D/UQCR11/CSNK2B	0.591184712250897
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	17/886	157/9376	1.14586418599301	NDUFA7/XBP1/TGFB1/SOCS3/MLXIP/LEP/FOS/PRKAG2/CASP7/RAC1/INSR/RXRA/TNF/ADIPOR1/PIK3R1/UQCR11/MAPK13	0.595395085357037
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/886	12/9376	1.76373212942062	VKORC1/VKORC1L1	0.855164444680271
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/886	21/9376	1.51177039664624	BCAT1/ALDH2/ALDH1B1	0.758423124001933
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/886	98/9376	1.18781959736491	IMPA2/PLCD3/IPMK/CALM3/CALM2/ITPR3/PIP4K2A/PIP5K1C/PIK3R1/DGKZ/INPP5B	0.603775398139766
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/886	168/9376	1.13382779748468	TNFAIP3/TNFSF10/FTH1/IFNGR2/PYGL/JAK1/STAT1/IFNAR2/TNFRSF10B/CAPN2/IFNAR1/STAT4/IRF9/STAT3/STAT6/TNF/EIF2AK2/GLUD1	0.565414536859934
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/886	31/9376	1.36547003568048	ALDOA/PFKP/PGM2/H6PD	0.658402731121828
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/886	31/9376	1.36547003568048	SHMT1/HYI/AGXT/MCEE	0.658402731121828
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/886	90/9376	1.17582141961374	EIF4EBP1/EIF4E/FOXO1/PRKAG2/SOD2/CREB3L2/INSR/ADCY7/ADIPOR1/PIK3R1	0.541411344289351
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/886	120/9376	1.1464258841234	ARHGDIB/MAPK3/MAP2K1/CALM3/CALM2/RIPK2/RAP1A/RAC1/RAP1B/PIK3R1/CRKL/RPS6KA1/MAPK13	0.521489368602534
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/886	41/9376	1.29053570445411	PIPOX/SHMT1/PHGDH/PSAT1/AGXT	0.602258492132233
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/886	51/9376	1.24498738547338	ACTG1/ACTB/KDELR2/KDELR3/ERO1A/SEC61G	0.566699780888403
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/886	174/9376	1.09473028722659	XBP1/KRTCAP2/ERO1A/CKAP4/SEC24D/CAPN2/SEC23A/SSR1/EDEM1/DNAJC10/SEC61G/FBXO6/DERL3/UBE2D1/PPP1R15A/CRYAB/SSR3/RNF5	0.407446899924612
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/886	33/9376	1.28271427594227	STX11/SNAP23/BET1/STX4	0.525545338980156
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/886	43/9376	1.23051078796787	ALDH2/ACSL4/CPT1A/ALDH1B1/ACOX1	0.489399480712443
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/886	53/9376	1.19800672941778	CLTB/ATP1B1/GNAQ/DNM2/PTH1R/ATP1A1	0.466969695066631
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	15/886	144/9376	1.10233258088789	TCF7L2/SCD/MAP2K3/ALDH2/FOXO1/PRKAG2/CPT1A/ALDH1B1/CXCL2/ACOX1/TNF/ADIPOR1/MAPK13/C2/TRAF3	0.399756864075873
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/886	63/9376	1.17582141961374	GADD45A/TCF7L2/CDKN1A/WNT7A/FZD8/APC/AXIN1	0.452320123345048
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/886	44/9376	1.20254463369588	ARHGDIB/AQP3/CREB3L2/DYNC1LI1/STX4	0.435019143005556
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/886	115/9376	1.10424968102856	MAPK3/GNB1/MAP2K1/GNB5/FOS/CHRM5/ITPR3/GNAQ/GNG10/CREB3L2/ADCY7/PIK3R1	0.363365229262046
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	25/886	250/9376	1.05823927765237	CTSH/LITAF/AP3S1/GM2A/LAPTM4A/CLTB/NPC2/CTSZ/CD68/IDS/SLC15A3/HEXB/LAPTM4B/CTSB/NCOA7/NAGA/CD63/SLC11A2/AGA/KXD1/OSBPL1A/ENTPD4/ABCA2/SLC36A4/GAA	0.301504921712281
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/886	75/9376	1.12878856282919	GPX3/ATP1B1/ITPR3/GNAQ/GPX8/CREB3L2/ADCY7/ATP1A1	0.361736023704949
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	32/886	323/9376	1.04841042987232	TPM1/TIMP3/ITGA5/SLC7A1/TGFB2/RECK/MAPK3/FSCN1/CDKN1A/MAP2K1/NOTCH2/PDGFB/SOX4/BMI1/BMPR2/PIM1/MARCKS/IGF2BP1/DDIT4/EFNA1/PLAU/VEGFA/STAT3/PIK3R1/TRIM71/APC/E2F3/CDKN2A/CRKL/ERBB2/FGFR3/MYC	0.286017491968808
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/886	65/9376	1.13964229901024	MAPK3/KISS1R/MAP2K1/ITPR3/GNAQ/PIK3R1/KISS1	0.364942261723736
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/886	45/9376	1.17582141961374	TAP1/ABCA7/TAP2/ABCA1/ABCA2	0.381911379163089
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	16/886	158/9376	1.0716347115467	TGFB1/GADD45A/TGFB2/CDKN1A/SMAD3/PPP2R5E/YWHAZ/YWHAG/PPP2R5A/YWHAQ/RBL2/MAD2L2/E2F3/CDKN2A/CDC26/MYC	0.293347480192643
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/886	86/9376	1.10745970917109	ITGA5/ACTG1/PKP2/ACTB/TCF7L2/ITGA1/ITGA2/ITGA3/ITGB6	0.323396774118451
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/886	56/9376	1.13382779748468	EEF1G/EEF1A1/CASP7/RAB1A/CXCL2/TNF	0.324474851109966
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/886	57/9376	1.11393608173934	SCD/ACSL4/CPT1A/HSD17B8/ACOX1/FADS1	0.278716516881185
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/886	47/9376	1.12578646558763	LDHA/PKM/ALDH2/GLO1/ALDH1B1	0.279263354676783
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/886	99/9376	1.06892856328522	IL1RAP/MAP2K3/CALM3/CALM2/ITPR3/GNAQ/IL1R1/ADCY7/PIK3R1/MAPK13	0.222721272569061
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/886	89/9376	1.07012960661476	TUBB2A/TUBB6/MAPK3/MAP2K1/PDGFB/TUBA1C/ITPR3/GNAQ/ADCY7	0.214737225405875
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/886	100/9376	1.05823927765237	TNFSF10/IL2RB/CSF1R/IL10RA/TNFRSF10B/XCR1/CCR1/ACKR3/CXCL2/TNF	0.189140382848627
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/886	27/9376	1.17582141961374	SCD/ACOX1/FADS1	0.295542361044664
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/886	48/9376	1.10233258088789	BCAT1/ALDH2/ALDH1B1/AACS/MCEE	0.229609012846501
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/886	69/9376	1.07357607877777	PPP3CA/CALM3/CALM2/ITPR3/GNAQ/CTSB/PPP3CC	0.198154975200281
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/886	17/9376	1.24498738547338	CA2/GLUD1	0.326589421870895
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/886	17/9376	1.24498738547338	MYH9/PCDH1	0.326589421870895
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/886	59/9376	1.07617553659563	GPX3/GSTM3/SRM/GPX8/PRDX6/ODC1	0.189606025312866
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/886	38/9376	1.11393608173934	NT5E/NAMPT/NMNAT2/BST1	0.227339446100936
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/886	38/9376	1.11393608173934	TAP1/TAP2/ADA/CD40	0.227339446100936
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/886	154/9376	1.03075254316789	ACTG1/ACTB/PPP3CA/MAPK3/CDKN1A/MYL6/MAP2K1/FOS/CALM3/CALM2/PRKAG2/ITPR3/GNAQ/ADCY7/PPP3CC	0.124301821363294
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/886	70/9376	1.05823927765237	ACTG1/HLA-G/ACTB/HLA-E/RAC1/CAV1/CD40	0.157990920590086
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/886	28/9376	1.13382779748468	B4GALT2/B4GALT3/B4GALT4	0.229094492268596
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	13/886	134/9376	1.02665004548364	MYH9/MAPK3/CALD1/MYL6/MAP2K1/PLA2G10/ADM/CALM3/CALM2/ITPR3/GNAQ/ADCY7/ADORA2B	0.100372796830697
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/886	60/9376	1.05823927765237	MAPK3/LYN/MAP2K1/ITPR3/GNAQ/CRH	0.146192643434276
NA	NA	hsa04081	Hormone signaling	21/886	219/9376	1.0147499922694	CSH1/DIO2/IGF2/GNB1/POMC/GUCA2A/GNB5/THRB/EPOR/LEP/GNAQ/STAT3/GNG10/INSR/CRH/ADCY7/BMPR1B/PTH1R/ADIPOR1/PIK3R1/GH2	0.0713486724869247
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/886	39/9376	1.085373618105	HLA-G/HLA-E/CD40/TNF	0.17258417275753
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/886	71/9376	1.04333449909389	JAM2/LYN/F11R/ADAM10/RAC1/CXCL2/MAPK13	0.11840046841429
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/886	50/9376	1.05823927765237	TGFB1/TGFB2/CD40/TNF/THBS3	0.133383445084433
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/886	18/9376	1.17582141961374	ACSL4/HSD17B8	0.24119326050462
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/886	18/9376	1.17582141961374	HEXB/AGA	0.24119326050462
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/886	29/9376	1.09473028722659	GNB1/CALM3/CALM2	0.165044245155077
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/886	104/9376	1.01753776697343	LPCAT1/PLPP2/PLA2G10/LYPLA1/LPCAT2/CHKB/AGPAT2/LPCAT4/DGKZ/ETNK2	0.058096893045492
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/886	83/9376	1.0199896652071	RYBP/BMI1/BCOR/UBE2D1/DCAF7/PHC2/RNF2/CSNK2B	0.0590901717266879
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	24/886	254/9376	0.999911128490429	FLT1/FGFR1/PPP3CA/PTK2B/PDGFB/PTGER3/PLCD3/SPHK1/EDNRB/CALM3/CHRM5/CALM2/ITPR3/GNAQ/VEGFA/ORAI2/GNAL/FLT4/ADCY7/ADORA2B/PPP3CC/ERBB2/GRIN2D/FGFR3	-0.00046385584720859
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/886	105/9376	1.0078469310975	RRAS/GABARAP/HIF1A/CITED2/PINK1/BNIP3L/TOMM7/CCZ1B/CCZ1/CSNK2B	0.0261204017364774
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/886	19/9376	1.11393608173934	IDS/HEXB	0.160589971028766
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/886	42/9376	1.0078469310975	AOC1/ALDH2/AADAT/ALDH1B1	0.0164641471925426
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/886	31/9376	1.02410252676036	UGDH/ALDH2/ALDH1B1	0.0434212600122186
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/886	31/9376	1.02410252676036	ALDH2/ALDH1B1/ACOX1	0.0434212600122186
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/886	75/9376	0.987689992475546	MAPK3/CDKN1A/GSTM3/PIK3R1/CDKN2A/ERBB2/ERCC1	-0.0345758433501575
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/886	65/9376	0.976836256294496	PLPP2/MGLL/ALDH2/ALDH1B1/AGPAT2/DGKZ	-0.0605363065331342
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/886	32/9376	0.992099322799097	LDHA/ACOX1/MCEE	-0.0144617732031211
Human Diseases	Immune disease	hsa05310	Asthma	3/886	32/9376	0.992099322799097	PRG2/CD40/TNF	-0.0144617732031211
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/886	99/9376	0.9620357069567	KRT19/KRT18/KRT14/KRT17/KRT15/C1S/KRT10/CFB/C2	-0.122669837521498
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	15/886	166/9376	0.95624031113166	PPP3CA/MAPK3/MAP2K1/EDNRB/CALM3/CALM2/ATP1B1/ITPR3/GNAQ/VASP/CREB3L2/INSR/ADCY7/ATP1A1/PPP3CC	-0.183758360936963
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/886	78/9376	0.949701915841871	IMPA2/PLCD3/TPI1/IPMK/PIP4K2A/PIP5K1C/INPP5B	-0.14409623303833
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/886	33/9376	0.9620357069567	BCAT1/AGXT/AADAT	-0.0705728679249905
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/886	45/9376	0.940657135690996	HLA-G/HLA-E/KLRD1/TNF	-0.12890190058486
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	24/886	268/9376	0.947676965061824	TUBB2A/TUBB6/NDUFA7/XBP1/UBE2L6/SLC39A6/TXN/SLC39A4/DUSP1/SLC39A8/CALM3/PINK1/TUBA1C/CALM2/SLC39A13/SLC39A14/ITPR3/TH/PSMD9/GNAL/SLC11A2/DAXX/SLC39A9/UQCR11	-0.280735585769147
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/886	46/9376	0.9202080675238	FTH1/BLVRB/CPOX/ALAD	-0.175245038573434
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/886	46/9376	0.9202080675238	PSMB8/PSMB10/PSMD9/PSMB9	-0.175245038573434
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/886	23/9376	0.9202080675238	B4GALT2/B4GALT3	-0.123764499018573
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/886	23/9376	0.9202080675238	PRCP/LNPEP	-0.123764499018573
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/886	93/9376	0.910313357120319	CALM3/CALM2/ATP1B1/ITPR3/GNAQ/ADCY7/ATP1A1/BST1	-0.280784882123802
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/886	59/9376	0.896812947163026	MGLL/PTGER3/INSR/ADCY7/PIK3R1	-0.256839502897438
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/886	36/9376	0.881866064710308	UGDH/CRYL1/SORD	-0.229404080054687
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/886	24/9376	0.881866064710308	EXTL3/HS6ST1	-0.187187436725882
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/886	48/9376	0.881866064710308	HK2/ATP1B1/PIK3R1/ATP1A1	-0.265063345712505
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	10/886	117/9376	0.904478015087496	ACTG1/ACTB/MORF4L2/SMARCA1/CHD3/CDK2AP1/BAZ1A/MBD2/CHRAC1/MORF4L1	-0.335863555526085
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/886	83/9376	0.892490957056216	PIPOX/CRAT/ACSL4/SOD2/AGXT/ACOX1/PHYH	-0.317800610660676
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/886	95/9376	0.89114886539147	FLT1/TGFB1/TGFB2/FOS/VEGFA/IL11/CXCL2/TNF	-0.344465737162496
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/886	72/9376	0.881866064710308	ISG15/ADAR/TRIM25/TNF/MAPK13/TRAF3	-0.325053407336492
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/886	37/9376	0.858031846745165	LAMA4/GNAQ/TNF	-0.279505437679645
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/886	49/9376	0.863868798083567	FOSB/TH/CREB3L2/GRIN2D	-0.308626621446637
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/886	142/9376	0.894286713509045	UBE2L6/SOCS3/BIRC7/CBLB/MID1/HERC1/UBE2Q2/UBE2D1/UBE2E2/UBE2E1/CBLC/CDC26	-0.410041171652739
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/886	26/9376	0.814030213578746	PLA2G10/ACOX1	-0.306741060598052
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/886	110/9376	0.86583213626103	MAPK3/MAP2K1/STK10/ADCY7/MAD2L2/PIK3R1/RPS6KA1/MAPK13/CDC26	-0.45724330322719
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/886	87/9376	0.851456890065125	TPM1/TPM4/TPM3/TPM2/ATP1B1/ATP1A1/UQCR11	-0.449651773893889
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/886	39/9376	0.814030213578746	MTHFD1L/MTHFD2/SHMT1	-0.37594098106437
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/886	52/9376	0.814030213578746	SCARB1/HSD3B1/INSR/ADCY7	-0.434401769569157
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/886	158/9376	0.870703203131697	EIF4EBP1/MAPK3/MAP2K1/EIF4E/WNT7A/DDIT4/INSR/FZD8/TNF/PIK3R1/WDR59/NPRL2/RPS6KA1	-0.529476405214085
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/886	90/9376	0.823074993729621	CA2/SCARB1/ATP1B1/NCEH1/ADCY7/RXRA/ATP1A1	-0.544809646593021
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/886	149/9376	0.852273243746875	NDUFA7/MGLL/MAPK3/GNB1/GNB5/SLC17A8/ITPR3/GNAQ/GNG10/ADCY7/DAGLB/MAPK13	-0.587179236258121
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/886	91/9376	0.814030213578746	PDE4C/GNB1/GNB5/PDE10A/GNG10/PDE4A/ADCY7	-0.575865138859269
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/886	30/9376	0.705492851768247	SHMT1/TNF	-0.521905932393536
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/886	16/9376	0.661399548532731	MIF	-0.437883170372201
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/886	44/9376	0.721526780217525	HLA-G/HLA-E/TNF	-0.598096228022836
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/886	17/9376	0.622493692736688	PAPSS1	-0.503248632183715
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/886	32/9376	0.661399548532731	BIRC7/CASP7	-0.619790280133756
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/886	73/9376	0.724821423049569	MX1/ELL2/BST2/SUPT5H/MX2	-0.762453204464774
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/886	86/9376	0.738306472780723	ATP1B1/ITPR3/GNAQ/CREB3L2/ADCY7/ATP1A1	-0.787558827054457
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/886	115/9376	0.73616645401904	MAPK3/DUSP1/GNB1/MAP2K1/GNB5/ITPR3/GNAQ/GNG10	-0.919599330919067
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/886	20/9376	0.529119638826185	SOAT1	-0.680971793120351
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	39/886	480/9376	0.859819413092551	GPX3/TUBB2A/TUBB6/NDUFA7/XBP1/UBE2L6/PPP3CA/MAPK3/HIP1/MAP2K3/MAP2K1/PRNP/ATXN1/WNT7A/CAPN2/CALM3/DNAH11/CHRM5/PINK1/TUBA1C/CALM2/ITPR3/GNAQ/PSMD9/CASP7/RAB1A/RAC1/GPX8/DAXX/FZD8/TNF/APC/PPP3CC/FRAT2/AXIN1/GRIN2D/UQCR11/MAPK13/CSNK2B	-1.0184970127281
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	29/886	368/9376	0.833938561193444	GPX3/ACTG1/TUBB2A/TUBB6/NDUFA7/XBP1/ACTB/PPP3CA/MAP2K3/PFN2/PFN1/HNRNPA1/DNAH11/PINK1/TUBA1C/ITPR3/PSMD9/RAB1A/RAC1/NXT1/ANG/GPX8/DAXX/TNF/NUP155/PPP3CC/GRIN2D/UQCR11/MAPK13	-1.04984980297912
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/886	275/9376	0.808109993843628	CAV2/TUBB2A/TUBB6/NDUFA7/PPP3CA/MAPK3/PRNP/TUBA1C/ITPR3/PSMD9/RAC1/CAV1/CREB3L2/TNF/PIK3R1/C9/PPP3CC/GRIN2D/UQCR11/MAPK13/CSNK2B	-1.04333265517955
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/886	37/9376	0.572021231163443	MIF/TH	-0.842600191372029
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/886	79/9376	0.66977169471669	SLC6A2/SLC1A6/CLTB/SLC17A8/DNM2	-0.952149360265224
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/886	217/9376	0.780268591817416	KLF4/EIF4EBP1/MAPK3/MAP2K1/NOTCH2/GSTM3/FOS/VEGFA/STAT3/CREB3L2/ADCY7/RXRA/PIK3R1/KLF5/RPS6KA1/MYC	-1.05790490414901
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/886	144/9376	0.73488838725859	XBP1/SLC1A6/ATXN1/ITPR3/GNAQ/ATXN10/PSMD9/VLDLR/PIK3R1/GRIN2D	-1.03564462090245
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/886	169/9376	0.75141250484192	DAPK1/MAPK3/RRAS/GABARAP/MAP2K1/HIF1A/EIF2AK4/DDIT4/RAB1A/CTSB/PIK3R1/WDR45	-1.05344584137898
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/886	108/9376	0.685895828108018	EEF1A1/SUMO2/NXT1/SUMO3/XPOT/NUP155/XPO6	-1.06057460493569
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/886	54/9376	0.587910709806872	HLA-G/HLA-E/CD40	-0.981030054334805
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/886	23/9376	0.4601040337619	GLUD1	-0.837427440468847
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/886	23/9376	0.4601040337619	NUS1	-0.837427440468847
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/886	23/9376	0.4601040337619	POLD4	-0.837427440468847
NA	NA	hsa04082	Neuroactive ligand signaling	14/886	199/9376	0.744489944077044	SLC6A2/SLC1A6/GNB1/POMC/GNB5/CHRM5/SLC17A8/TAC3/GNAQ/GNAL/GNG10/ADCY7/ADORA2B/GRIN2D	-1.17688173680428
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/886	41/9376	0.516214281781644	SLC17A8/GRIN2D	-1.00285112191888
Human Diseases	Substance dependence	hsa05034	Alcoholism	13/886	191/9376	0.720267571177006	FOSB/MAPK3/GNB1/MAP2K1/GNB5/CALM3/CALM2/TH/GNG10/CREB3L2/CRH/ADORA2B/GRIN2D	-1.26173622931377
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/886	26/9376	0.407015106789373	SCARB1	-0.978077238041409
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	14/886	205/9376	0.722699994494302	NDUFA7/TGFB1/MMP2/TGFB2/SMAD3/GYS1/GAPDH/PDK3/RAC1/MPC1/INSR/PIK3R1/UQCR11/MAPK13	-1.29678242512532
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/886	44/9376	0.48101785347835	TAF5L/TAF3	-1.11465391353703
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/886	27/9376	0.391940473204582	AACS	-1.0221015653247
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/886	89/9376	0.594516448119309	GABARAP/GNB1/GNB5/GNG10/ADCY7	-1.24159277488742
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/886	103/9376	0.616450064651866	PABPC1/PPP2R2B/PPP2R5E/NXT1/PPP2R3A/PPP2R5A	-1.26438417143699
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/886	28/9376	0.377942599161561	CA2	-1.06487536285812
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/886	63/9376	0.503923465548748	HPGD/PLA2G10/CBR1	-1.27621196407422
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/886	30/9376	0.352746425884123	ACLY	-1.14701962964977
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/886	30/9376	0.352746425884123	PIGA	-1.14701962964977
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/886	30/9376	0.352746425884123	PLA2G10	-1.14701962964977
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/886	227/9376	0.699277055717425	NDUFA7/MAPK3/PRKD3/MAP2K1/HIF1A/GSTM3/PTK2/FOS/CBR1/SOD2/RAC1/VEGFA/PIK3R1/UQCR11/MAPK13	-1.48163535815925
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/886	31/9376	0.341367508920119	SEC61G	-1.186541682207
NA	NA	hsa04981	Folate transport and metabolism	1/886	31/9376	0.341367508920119	SHMT1	-1.186541682207
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/886	66/9376	0.48101785347835	HSD3B1/HSD17B8/HSD11B1L	-1.36677869109021
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/886	50/9376	0.423295711060948	TGFB1/CD40	-1.32080630039423
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/886	32/9376	0.330699774266366	GABARAP	-1.22511878706439
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/886	83/9376	0.509994832603552	ADAR/CASP7/POLR3GL/PCBP1	-1.44847295782277
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/886	68/9376	0.466870269552516	RDH13/CYP26A1/CYP26B1	-1.42530505390437
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/886	235/9376	0.675471879352577	ACTG1/NDUFA7/FGFR1/ACTB/MGLL/MAP2K3/COX16/ACSL4/PRKAG2/CPT1A/CREB3L2/ADCY7/RPS6KA1/UQCR11/MAPK13	-1.62756396365185
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/886	34/9376	0.311246846368344	POLR3GL	-1.29966607111262
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/886	70/9376	0.453531118993873	GSTM3/CBR1/HSD11B1L	-1.48245522719801
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/886	36/9376	0.293955354903436	POLD4	-1.37106684788523
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/886	56/9376	0.377942599161561	KIF3A/CSNK1G1	-1.50822165732801
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/886	41/9376	0.258107140890822	POLD4	-1.53788765993592
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/886	79/9376	0.401863016830014	GSTM3/CBR1/HSD11B1L	-1.72461214488465
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/886	143/9376	0.518019226822839	ACTN1/ACTN4/C1S/CD40/TNF/C9/C2	-1.87618201708815
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/886	63/9376	0.335948977032498	POLD4/ERCC1	-1.70834498592903
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/886	44/9376	0.240508926739175	POLD4	-1.63121159905123
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	22/886	370/9376	0.629223354279788	CSH1/TSPO/KISS1R/POMC/PTGER3/EDNRB/THRB/ADM/LEP/CHRM5/NPFFR2/TAC3/CHRNE/CRH/ADORA2B/PTH1R/VGF/LPAR2/KISS1/NMB/GH2/GRIN2D	-2.35069301031592
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/886	54/9376	0.195970236602291	ERCC1	-1.9140933318194
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/886	195/9376	0.434149447241998	ACTG1/ACTB/MAPK3/MAP2K1/RAC1/PIK3R1/CLEC7A/MAPK13	-2.57942384620793
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/886	73/9376	0.144964284609914	GSTM3	-2.36909692736886
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/886	308/9376	0.48101785347835	GPX3/TUBB2A/TUBB6/NDUFA7/HIP1/CLTB/DNAH11/TUBA1C/SOD2/GNAQ/PSMD9/GPX8/CREB3L2/UQCR11	-2.99171813832295
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/886	183/9376	0.346963697590941	RRP7A/GNL3/NXT1/DKC1/RPP38/CSNK2B	-2.88192645231415
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/886	86/9376	0.123051078796787	ITPR3	-2.63915149567597
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/886	138/9376	0.23005201688095	NDUFA7/LHPP/UQCR11	-2.94347671070553
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/886	243/9376	0.174195765868703	HNRNPA1/SART1/PCBP1/SNRPA1	-4.21329790401782
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/886	449/9376	0.0942752140447546	GNB1/CALM3/CALM2/GNAL	-6.35353329141539