ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003779 actin binding 100/1626 443/18639 0.225733634311512 2.58760714017975 3.03653502032262e-19 3.62258627924489e-16 GO:0045296 cadherin binding 77/1626 334/18639 0.230538922155689 2.64269063349316 1.26026709881079e-15 7.51749324440638e-13 GO:0051015 actin filament binding 54/1626 209/18639 0.258373205741627 2.96175779939618 1.81709290229034e-13 7.22597277477457e-11 GO:0019838 growth factor binding 31/1626 136/18639 0.227941176470588 2.61291241588886 5.25988552565505e-07 0.000156876085802662 GO:0140297 DNA-binding transcription factor binding 71/1626 488/18639 0.145491803278689 1.66778703647692 1.25450888080684e-05 0.00299325818960513 GO:0019955 cytokine binding 29/1626 144/18639 0.201388888888889 2.30854089790898 1.61039365786237e-05 0.00302535021524347 GO:0031418 L-ascorbic acid binding 9/1626 20/18639 0.45 5.15839483394834 1.97622016107953e-05 0.00302535021524347 GO:0035259 nuclear glucocorticoid receptor binding 7/1626 12/18639 0.583333333333333 6.68680811808118 2.02873442765698e-05 0.00302535021524347 GO:0016757 glycosyltransferase activity 44/1626 267/18639 0.164794007490637 1.88905012645632 2.94903065202323e-05 0.00390910396429301 GO:0019207 kinase regulator activity 46/1626 287/18639 0.160278745644599 1.83729123005516 4.00475952896335e-05 0.00477767811805328 GO:0019887 protein kinase regulator activity 42/1626 255/18639 0.164705882352941 1.88803993922292 4.48602245252414e-05 0.00486529525987391 GO:0005201 extracellular matrix structural constituent 31/1626 168/18639 0.18452380952381 2.11521481286241 5.02191734368545e-05 0.00499262282584729 GO:0030246 carbohydrate binding 44/1626 280/18639 0.157142857142857 1.80134422772799 9.35430662339514e-05 0.00858437523208493 GO:0001968 fibronectin binding 10/1626 30/18639 0.333333333333333 3.8210332103321 0.000146334127500827 0.0124697581506062 GO:0019210 kinase inhibitor activity 19/1626 90/18639 0.211111111111111 2.419987699877 0.000235601218706349 0.0180952701080979 GO:0004857 enzyme inhibitor activity 58/1626 416/18639 0.139423076923077 1.59822062162929 0.00024268593606837 0.0180952701080979 GO:0004860 protein kinase inhibitor activity 18/1626 84/18639 0.214285714285714 2.45637849235635 0.000280232978817638 0.0196657613958495 GO:0044389 ubiquitin-like protein ligase binding 47/1626 322/18639 0.145962732919255 1.67318534986592 0.000324970273460357 0.0215383075687892 GO:0016758 hexosyltransferase activity 32/1626 197/18639 0.16243654822335 1.8620263359994 0.000442904965687068 0.0278097696876143 GO:0048029 monosaccharide binding 16/1626 74/18639 0.216216216216216 2.47850802832353 0.000539544925150183 0.0321838547852084 GO:1901981 phosphatidylinositol phosphate binding 30/1626 185/18639 0.162162162162162 1.85888102124264 0.000676388448009611 0.0384253056416888 GO:0008194 UDP-glycosyltransferase activity 25/1626 145/18639 0.172413793103448 1.97639648810281 0.000741820794508139 0.040226918538555 GO:0019199 transmembrane receptor protein kinase activity 16/1626 78/18639 0.205128205128205 2.35140505251206 0.000989964905194204 0.0513490492128994 GO:0005539 glycosaminoglycan binding 36/1626 242/18639 0.148760330578512 1.70525449056143 0.00109074114798863 0.05289810501767 GO:0001223 transcription coactivator binding 11/1626 44/18639 0.25 2.86577490774908 0.00110851016382376 0.05289810501767 GO:0005518 collagen binding 15/1626 72/18639 0.208333333333333 2.38814575645756 0.00119224990871105 0.0544176969450585 GO:0005160 transforming growth factor beta receptor binding 8/1626 26/18639 0.307692307692308 3.5271075787681 0.00123158241200049 0.0544176969450585 GO:1902936 phosphatidylinositol bisphosphate binding 20/1626 111/18639 0.18018018018018 2.06542335693627 0.00138826945966236 0.0588683406602392 GO:0004896 cytokine receptor activity 18/1626 96/18639 0.1875 2.14933118081181 0.00147992669132825 0.0588683406602392 GO:0005114 type II transforming growth factor beta receptor binding 5/1626 11/18639 0.454545454545455 5.21049983227105 0.00148160340183175 0.0588683406602392 GO:0005385 zinc ion transmembrane transporter activity 8/1626 27/18639 0.296296296296296 3.39647396473965 0.00161778067180565 0.0588683406602392 GO:0005024 transforming growth factor beta receptor activity 6/1626 16/18639 0.375 4.29866236162362 0.0016232440269678 0.0588683406602392 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 13/1626 60/18639 0.216666666666667 2.48367158671587 0.00170500403263498 0.0588683406602392 GO:0031625 ubiquitin protein ligase binding 42/1626 302/18639 0.139072847682119 1.59420590894651 0.00172117522428589 0.0588683406602392 GO:0035091 phosphatidylinositol binding 40/1626 284/18639 0.140845070422535 1.61452107478821 0.00172706783160802 0.0588683406602392 GO:0019003 GDP binding 15/1626 75/18639 0.2 2.29261992619926 0.00183703294987662 0.0600996773839738 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 47/1626 349/18639 0.134670487106017 1.54374121105108 0.00186394640671168 0.0600996773839738 GO:0003925 G protein activity 12/1626 54/18639 0.222222222222222 2.54735547355474 0.002018107757239 0.0633579619575297 GO:0035401 histone H3Y41 kinase activity 20/1626 115/18639 0.173913043478261 1.9935825445211 0.00215758039620572 0.0635768761662348 GO:0140801 histone H2AXY142 kinase activity 20/1626 115/18639 0.173913043478261 1.9935825445211 0.00215758039620572 0.0635768761662348 GO:0019209 kinase activator activity 24/1626 148/18639 0.162162162162162 1.85888102124264 0.00221783295073559 0.0635768761662348 GO:0004550 nucleoside diphosphate kinase activity 6/1626 17/18639 0.352941176470588 4.0457998697634 0.00232496752257391 0.0635768761662348 GO:0008179 adenylate cyclase binding 5/1626 12/18639 0.416666666666667 4.77629151291513 0.00235828169250011 0.0635768761662348 GO:0031543 peptidyl-proline dioxygenase activity 5/1626 12/18639 0.416666666666667 4.77629151291513 0.00235828169250011 0.0635768761662348 GO:0015294 solute:monoatomic cation symporter activity 20/1626 116/18639 0.172413793103448 1.97639648810281 0.00239812190065429 0.0635768761662348 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 8/1626 29/18639 0.275862068965517 3.1622343809645 0.00267336727969335 0.069333199232047 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 6/1626 18/18639 0.333333333333333 3.8210332103321 0.00323259447290602 0.0803434417953517 GO:0098641 cadherin binding involved in cell-cell adhesion 6/1626 18/18639 0.333333333333333 3.8210332103321 0.00323259447290602 0.0803434417953517 GO:0005178 integrin binding 25/1626 161/18639 0.15527950310559 1.77998441475098 0.00331342120567605 0.0804294668598485 GO:0016769 transferase activity, transferring nitrogenous groups 8/1626 30/18639 0.266666666666667 3.05682656826568 0.00337089131851838 0.0804294668598485 GO:0050431 transforming growth factor beta binding 7/1626 24/18639 0.291666666666667 3.34340405904059 0.00348114329448255 0.0814314500062291 GO:0140410 monoatomic cation:bicarbonate symporter activity 5/1626 13/18639 0.384615384615385 4.40888447346012 0.00355886077215111 0.0816484788687744 GO:0005200 structural constituent of cytoskeleton 19/1626 112/18639 0.169642857142857 1.94463297311545 0.00366093919668788 0.0824056690877103 GO:0043394 proteoglycan binding 9/1626 37/18639 0.243243243243243 2.78832153186397 0.00376630537517483 0.0832074502330291 GO:0035591 signaling adaptor activity 21/1626 129/18639 0.162790697674419 1.86608598644126 0.00385960310613148 0.0837183001020883 GO:0015293 symporter activity 23/1626 146/18639 0.157534246575342 1.80583076378709 0.00393236942944391 0.0837735130236889 GO:0030695 GTPase regulator activity 60/1626 489/18639 0.122699386503067 1.40651529214679 0.00441397347681429 0.0905097641199423 GO:0030295 protein kinase activator activity 22/1626 139/18639 0.158273381294964 1.81430353871884 0.0044677293500866 0.0905097641199423 GO:0019211 phosphatase activator activity 7/1626 25/18639 0.28 3.20966789667897 0.00447617442001391 0.0905097641199423 GO:0060589 nucleoside-triphosphatase regulator activity 60/1626 490/18639 0.122448979591837 1.40364485277506 0.00461446995417184 0.0911028500880399 GO:0046915 transition metal ion transmembrane transporter activity 10/1626 45/18639 0.222222222222222 2.54735547355474 0.00465823458119902 0.0911028500880399 GO:0004713 protein tyrosine kinase activity 22/1626 140/18639 0.157142857142857 1.80134422772799 0.00487538312631655 0.0922580457417546 GO:0001221 transcription coregulator binding 19/1626 115/18639 0.165217391304348 1.89390341729504 0.00493031893286125 0.0922580457417546 GO:0005161 platelet-derived growth factor receptor binding 5/1626 14/18639 0.357142857142857 4.09396415392725 0.00514210769248377 0.0922580457417546 GO:0008191 metalloendopeptidase inhibitor activity 5/1626 14/18639 0.357142857142857 4.09396415392725 0.00514210769248377 0.0922580457417546 GO:0008378 galactosyltransferase activity 8/1626 32/18639 0.25 2.86577490774908 0.00518129846160734 0.0922580457417546 GO:0043425 bHLH transcription factor binding 8/1626 32/18639 0.25 2.86577490774908 0.00518129846160734 0.0922580457417546 GO:0038064 collagen receptor activity 11/1626 53/18639 0.207547169811321 2.37913388567848 0.0053351937982417 0.093601267666211 GO:0098631 cell adhesion mediator activity 14/1626 76/18639 0.184210526315789 2.11162361623616 0.00559840083176568 0.0967955390187892 GO:0019208 phosphatase regulator activity 19/1626 117/18639 0.162393162393162 1.86152899990538 0.00596248025870125 0.101617699266151 GO:0051287 NAD binding 11/1626 54/18639 0.203703703703704 2.33507585075851 0.00618375069245168 0.103904430649223 GO:0051020 GTPase binding 41/1626 315/18639 0.13015873015873 1.49202249165349 0.00634030339397892 0.105055304847456 GO:0001784 phosphotyrosine residue binding 10/1626 47/18639 0.212765957446809 2.43895736829709 0.00644812738494356 0.10537830096216 GO:0008514 organic anion transmembrane transporter activity 36/1626 269/18639 0.133828996282528 1.53409511790285 0.00655569342309194 0.105688408834442 GO:0019903 protein phosphatase binding 22/1626 144/18639 0.152777777777778 1.75130688806888 0.00682648125748355 0.108586561869038 GO:0098632 cell-cell adhesion mediator activity 11/1626 55/18639 0.2 2.29261992619926 0.00713466487876534 0.111995463162724 GO:0004674 protein serine/threonine kinase activity 53/1626 433/18639 0.122401847575058 1.40310457377091 0.00747928578440844 0.112038262827257 GO:0072542 protein phosphatase activator activity 6/1626 21/18639 0.285714285714286 3.2751713231418 0.00753230684495361 0.112038262827257 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 8/1626 34/18639 0.235294117647059 2.6971999131756 0.00765312464893681 0.112038262827257 GO:0016922 nuclear receptor binding 21/1626 137/18639 0.153284671532847 1.75711746168557 0.00779197850898456 0.112038262827257 GO:0061134 peptidase regulator activity 31/1626 226/18639 0.13716814159292 1.57237207327825 0.00783607706742128 0.112038262827257 GO:0140996 histone H3 kinase activity 45/1626 357/18639 0.126050420168067 1.4449285249155 0.00783621511284473 0.112038262827257 GO:0005522 profilin binding 4/1626 10/18639 0.4 4.58523985239852 0.00788869579001641 0.112038262827257 GO:0031996 thioesterase binding 4/1626 10/18639 0.4 4.58523985239852 0.00788869579001641 0.112038262827257 GO:0031267 small GTPase binding 37/1626 283/18639 0.130742049469965 1.49870913903485 0.00854833612944149 0.11997841179322 GO:0016763 pentosyltransferase activity 10/1626 49/18639 0.204081632653061 2.33940808795843 0.00873053334283617 0.12111077067446 GO:0048306 calcium-dependent protein binding 14/1626 80/18639 0.175 2.00604243542435 0.00886969724888178 0.12162699790708 GO:0035173 histone kinase activity 45/1626 360/18639 0.125 1.43288745387454 0.00906153188103694 0.122845540159967 GO:0005543 phospholipid binding 59/1626 497/18639 0.118712273641851 1.36081062017864 0.00937224442558508 0.124397519192425 GO:0019001 guanyl nucleotide binding 49/1626 400/18639 0.1225 1.40422970479705 0.00968304485564518 0.124397519192425 GO:0032561 guanyl ribonucleotide binding 49/1626 400/18639 0.1225 1.40422970479705 0.00968304485564518 0.124397519192425 GO:0005521 lamin binding 5/1626 16/18639 0.3125 3.58221863468635 0.00968505566094219 0.124397519192425 GO:0003735 structural constituent of ribosome 25/1626 175/18639 0.142857142857143 1.6375856615709 0.00969737576269535 0.124397519192425 GO:0005085 guanyl-nucleotide exchange factor activity 31/1626 230/18639 0.134782608695652 1.54502647200385 0.0100126890775975 0.125282173405083 GO:0005017 platelet-derived growth factor receptor activity 10/1626 50/18639 0.2 2.29261992619926 0.0100813819336865 0.125282173405083 GO:0005019 platelet-derived growth factor beta-receptor activity 10/1626 50/18639 0.2 2.29261992619926 0.0100813819336865 0.125282173405083 GO:0008375 acetylglucosaminyltransferase activity 9/1626 43/18639 0.209302325581395 2.39925341113876 0.0106422219455391 0.128288842981045 GO:0017124 SH3 domain binding 18/1626 115/18639 0.156521739130435 1.79422429006899 0.0106441591305034 0.128288842981045 GO:0035250 UDP-galactosyltransferase activity 7/1626 29/18639 0.241379310344828 2.76695508334394 0.0106912316172682 0.128288842981045 GO:0141003 histone H2AX kinase activity 44/1626 354/18639 0.124293785310734 1.42479204453061 0.0107534654636249 0.128288842981045 GO:0019888 protein phosphatase regulator activity 17/1626 107/18639 0.158878504672897 1.82124012828913 0.0111084523987915 0.131211719918398 GO:0005536 D-glucose binding 4/1626 11/18639 0.363636363636364 4.16839986581684 0.0115498914404077 0.132490581619292 GO:0008432 JUN kinase binding 4/1626 11/18639 0.363636363636364 4.16839986581684 0.0115498914404077 0.132490581619292 GO:1990948 ubiquitin ligase inhibitor activity 4/1626 11/18639 0.363636363636364 4.16839986581684 0.0115498914404077 0.132490581619292 GO:0140103 catalytic activity, acting on a glycoprotein 6/1626 23/18639 0.260869565217391 2.99037381678165 0.0120563768138187 0.135387137927753 GO:0045309 protein phosphorylated amino acid binding 11/1626 59/18639 0.186440677966102 2.13718806679592 0.0121230976997517 0.135387137927753 GO:0050840 extracellular matrix binding 12/1626 67/18639 0.17910447761194 2.05309247122322 0.0123535346159944 0.135387137927753 GO:0003725 double-stranded RNA binding 13/1626 75/18639 0.173333333333333 1.98693726937269 0.0123557082201436 0.135387137927753 GO:0019205 nucleobase-containing compound kinase activity 9/1626 44/18639 0.204545454545455 2.34472492452197 0.0123698223253354 0.135387137927753 GO:0038191 neuropilin binding 5/1626 17/18639 0.294117647058824 3.3714998914695 0.012751759051929 0.138298623172284 GO:0042805 actinin binding 8/1626 37/18639 0.216216216216216 2.47850802832353 0.0128931291264664 0.1385720995304 GO:0005080 protein kinase C binding 10/1626 52/18639 0.192307692307692 2.20444223673006 0.0132532417706267 0.141170691360337 GO:0003924 GTPase activity 41/1626 331/18639 0.123867069486405 1.4199005585222 0.0141804666946463 0.149710590855868 GO:0019902 phosphatase binding 26/1626 190/18639 0.136842105263158 1.56863468634686 0.014398944250303 0.150683688514135 GO:0008201 heparin binding 24/1626 172/18639 0.13953488372093 1.59950227409251 0.0145898424140593 0.151353756521502 GO:0015295 solute:proton symporter activity 6/1626 24/18639 0.25 2.86577490774908 0.0149147879869308 0.152079846738533 GO:0048027 mRNA 5'-UTR binding 6/1626 24/18639 0.25 2.86577490774908 0.0149147879869308 0.152079846738533 GO:0005078 MAP-kinase scaffold activity 4/1626 12/18639 0.333333333333333 3.8210332103321 0.0161456963143615 0.163235726296892 GO:0016776 phosphotransferase activity, phosphate group as acceptor 8/1626 39/18639 0.205128205128205 2.35140505251206 0.017602215167689 0.176465905000445 GO:0008483 transaminase activity 6/1626 25/18639 0.24 2.75114391143911 0.0182111922712203 0.179553325450957 GO:0042974 nuclear retinoic acid receptor binding 6/1626 25/18639 0.24 2.75114391143911 0.0182111922712203 0.179553325450957 GO:0046332 SMAD binding 13/1626 79/18639 0.164556962025316 1.88633285067028 0.0186622216528569 0.18249205272015 GO:0003714 transcription corepressor activity 27/1626 204/18639 0.132352941176471 1.51717495116128 0.0192057199982545 0.185771413681944 GO:0140313 molecular sequestering activity 10/1626 55/18639 0.181818181818182 2.08419993290842 0.0193387828038978 0.185771413681944 GO:0005525 GTP binding 45/1626 378/18639 0.119047619047619 1.36465471797575 0.0202076150971681 0.185771413681944 GO:0004177 aminopeptidase activity 8/1626 40/18639 0.2 2.29261992619926 0.0203695345058959 0.185771413681944 GO:0004532 RNA exonuclease activity 8/1626 40/18639 0.2 2.29261992619926 0.0203695345058959 0.185771413681944 GO:0015036 disulfide oxidoreductase activity 8/1626 40/18639 0.2 2.29261992619926 0.0203695345058959 0.185771413681944 GO:0071949 FAD binding 8/1626 40/18639 0.2 2.29261992619926 0.0203695345058959 0.185771413681944 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/1626 19/18639 0.263157894736842 3.01660516605166 0.0207104761271572 0.185771413681944 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5/1626 19/18639 0.263157894736842 3.01660516605166 0.0207104761271572 0.185771413681944 GO:0043395 heparan sulfate proteoglycan binding 5/1626 19/18639 0.263157894736842 3.01660516605166 0.0207104761271572 0.185771413681944 GO:0050145 nucleoside monophosphate kinase activity 5/1626 19/18639 0.263157894736842 3.01660516605166 0.0207104761271572 0.185771413681944 GO:0031406 carboxylic acid binding 25/1626 187/18639 0.133689839572193 1.53249995066796 0.0210727231239693 0.187610139454443 GO:0071889 14-3-3 protein binding 7/1626 33/18639 0.212121212121212 2.43156658839316 0.0215748714111417 0.189311208868391 GO:0005172 vascular endothelial growth factor receptor binding 4/1626 13/18639 0.307692307692308 3.5271075787681 0.0217398454442327 0.189311208868391 GO:0045159 myosin II binding 4/1626 13/18639 0.307692307692308 3.5271075787681 0.0217398454442327 0.189311208868391 GO:0043548 phosphatidylinositol 3-kinase binding 6/1626 26/18639 0.230769230769231 2.64533068407607 0.0219730848256965 0.189955726065623 GO:0043177 organic acid binding 25/1626 189/18639 0.132275132275132 1.51628301997306 0.0237094963346784 0.194248402788711 GO:0005004 GPI-linked ephrin receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0005008 hepatocyte growth factor receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0005009 insulin receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0005011 macrophage colony-stimulating factor receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0005018 platelet-derived growth factor alpha-receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0005020 stem cell factor receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0008288 boss receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0036332 placental growth factor receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0038062 protein tyrosine kinase collagen receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0060175 brain-derived neurotrophic factor receptor activity 9/1626 49/18639 0.183673469387755 2.10546727916259 0.0242606974145163 0.194248402788711 GO:0008376 acetylgalactosaminyltransferase activity 7/1626 34/18639 0.205882352941176 2.36004992402865 0.0251842131643059 0.19897196228488 GO:0015035 protein-disulfide reductase activity 7/1626 34/18639 0.205882352941176 2.36004992402865 0.0251842131643059 0.19897196228488 GO:0001972 retinoic acid binding 5/1626 20/18639 0.25 2.86577490774908 0.0256800816578187 0.201554851432748 GO:0008307 structural constituent of muscle 8/1626 42/18639 0.19047619047619 2.1834475487612 0.0268038050540881 0.208999604114556 GO:0002020 protease binding 19/1626 136/18639 0.139705882352941 1.60146244844801 0.0272025915356576 0.209335022350517 GO:0005006 epidermal growth factor receptor activity 9/1626 50/18639 0.18 2.06335793357934 0.0273732300810399 0.209335022350517 GO:0005007 fibroblast growth factor receptor activity 9/1626 50/18639 0.18 2.06335793357934 0.0273732300810399 0.209335022350517 GO:0005545 1-phosphatidylinositol binding 4/1626 14/18639 0.285714285714286 3.2751713231418 0.0283789405449322 0.214278962469014 GO:0044548 S100 protein binding 4/1626 14/18639 0.285714285714286 3.2751713231418 0.0283789405449322 0.214278962469014 GO:0000175 3'-5'-RNA exonuclease activity 7/1626 35/18639 0.2 2.29261992619926 0.0291855981350403 0.217615116094394 GO:0005154 epidermal growth factor receptor binding 7/1626 35/18639 0.2 2.29261992619926 0.0291855981350403 0.217615116094394 GO:0016500 protein-hormone receptor activity 11/1626 67/18639 0.164179104477612 1.88200143195462 0.0294997391165931 0.218591234572022 GO:0051213 dioxygenase activity 14/1626 93/18639 0.150537634408602 1.7256279014403 0.0304798178136596 0.221037783007198 GO:0051219 phosphoprotein binding 14/1626 93/18639 0.150537634408602 1.7256279014403 0.0304798178136596 0.221037783007198 GO:0005010 insulin-like growth factor receptor activity 9/1626 51/18639 0.176470588235294 2.0228999348817 0.0307563050957208 0.221037783007198 GO:0005021 vascular endothelial growth factor receptor activity 9/1626 51/18639 0.176470588235294 2.0228999348817 0.0307563050957208 0.221037783007198 GO:0005030 neurotrophin receptor activity 9/1626 51/18639 0.176470588235294 2.0228999348817 0.0307563050957208 0.221037783007198 GO:0030145 manganese ion binding 11/1626 68/18639 0.161764705882353 1.85432494030823 0.0325209161449088 0.230937220005216 GO:1990841 promoter-specific chromatin binding 11/1626 68/18639 0.161764705882353 1.85432494030823 0.0325209161449088 0.230937220005216 GO:0055106 ubiquitin-protein transferase regulator activity 7/1626 36/18639 0.194444444444444 2.22893603936039 0.0335945931054905 0.236271505741561 GO:0004714 transmembrane receptor protein tyrosine kinase activity 10/1626 60/18639 0.166666666666667 1.91051660516605 0.0336681944476658 0.236271505741561 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 13/1626 86/18639 0.151162790697674 1.73279413026688 0.035118479068971 0.245007868592295 GO:0051371 muscle alpha-actinin binding 4/1626 15/18639 0.266666666666667 3.05682656826568 0.0360928318247894 0.245959935959761 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/1626 15/18639 0.266666666666667 3.05682656826568 0.0360928318247894 0.245959935959761 GO:0003785 actin monomer binding 6/1626 29/18639 0.206896551724138 2.37167578572337 0.0362849173584957 0.245959935959761 GO:0043236 laminin binding 6/1626 29/18639 0.206896551724138 2.37167578572337 0.0362849173584957 0.245959935959761 GO:0042578 phosphoric ester hydrolase activity 42/1626 363/18639 0.115702479338843 1.32630904821445 0.0362857910552539 0.245959935959761 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/1626 22/18639 0.227272727272727 2.60524991613552 0.0377468867828601 0.252988965909843 GO:0140784 metal ion sensor activity 5/1626 22/18639 0.227272727272727 2.60524991613552 0.0377468867828601 0.252988965909843 GO:0005003 ephrin receptor activity 9/1626 53/18639 0.169811320754717 1.94656408828239 0.0383725960023628 0.254325039060105 GO:0005005 transmembrane-ephrin receptor activity 9/1626 53/18639 0.169811320754717 1.94656408828239 0.0383725960023628 0.254325039060105 GO:0008028 monocarboxylic acid transmembrane transporter activity 11/1626 70/18639 0.157142857142857 1.80134422772799 0.039208206103771 0.258427568407728 GO:0008017 microtubule binding 33/1626 276/18639 0.119565217391304 1.37058799935825 0.0396298421330018 0.259771437717973 GO:0015291 secondary active transmembrane transporter activity 34/1626 287/18639 0.118466898954704 1.35799786569294 0.0416231278123731 0.271346401530935 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/1626 30/18639 0.2 2.29261992619926 0.0421263563797673 0.273134473701426 GO:0030291 protein serine/threonine kinase inhibitor activity 8/1626 46/18639 0.173913043478261 1.9935825445211 0.0436288400337638 0.28021652649043 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 7/1626 38/18639 0.184210526315789 2.11162361623616 0.043688410668248 0.28021652649043 GO:0042171 lysophosphatidic acid acyltransferase activity 5/1626 23/18639 0.217391304347826 2.49197818065137 0.0448831395520383 0.280420108314818 GO:0071617 lysophospholipid acyltransferase activity 5/1626 23/18639 0.217391304347826 2.49197818065137 0.0448831395520383 0.280420108314818 GO:0005159 insulin-like growth factor receptor binding 4/1626 16/18639 0.25 2.86577490774908 0.0448954238794051 0.280420108314818 GO:0031435 mitogen-activated protein kinase kinase kinase binding 4/1626 16/18639 0.25 2.86577490774908 0.0448954238794051 0.280420108314818 GO:0140328 floppase activity 4/1626 16/18639 0.25 2.86577490774908 0.0448954238794051 0.280420108314818 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0005131 growth hormone receptor binding 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0005381 iron ion transmembrane transporter activity 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0005528 FK506 binding 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0008239 dipeptidyl-peptidase activity 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0031434 mitogen-activated protein kinase kinase binding 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0043422 protein kinase B binding 3/1626 10/18639 0.3 3.43892988929889 0.0499123641641005 0.296246022128218 GO:0043539 protein serine/threonine kinase activator activity 11/1626 73/18639 0.150684931506849 1.72731638275287 0.0509402865661591 0.300850306304098 GO:0140375 immune receptor activity 20/1626 156/18639 0.128205128205128 1.46962815782004 0.05238225063172 0.307093027294459 GO:0019957 C-C chemokine binding 5/1626 24/18639 0.208333333333333 2.38814575645756 0.0527695478586455 0.307093027294459 GO:0050699 WW domain binding 5/1626 24/18639 0.208333333333333 2.38814575645756 0.0527695478586455 0.307093027294459 GO:0032266 phosphatidylinositol-3-phosphate binding 8/1626 48/18639 0.166666666666667 1.91051660516605 0.0541835206669273 0.312608954790097 GO:0005092 GDP-dissociation inhibitor activity 4/1626 17/18639 0.235294117647059 2.6971999131756 0.0547857822878593 0.312608954790097 GO:0046965 nuclear retinoid X receptor binding 4/1626 17/18639 0.235294117647059 2.6971999131756 0.0547857822878593 0.312608954790097 GO:0048038 quinone binding 4/1626 17/18639 0.235294117647059 2.6971999131756 0.0547857822878593 0.312608954790097 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 7/1626 40/18639 0.175 2.00604243542435 0.0555516332066225 0.312608954790097 GO:0061791 GTPase motor activity 7/1626 40/18639 0.175 2.00604243542435 0.0555516332066225 0.312608954790097 GO:1990606 membrane scission GTPase motor activity 7/1626 40/18639 0.175 2.00604243542435 0.0555516332066225 0.312608954790097 GO:0052689 carboxylic ester hydrolase activity 13/1626 92/18639 0.141304347826087 1.61978581742339 0.0558748499204639 0.31295162420241 GO:0016504 peptidase activator activity 9/1626 57/18639 0.157894736842105 1.809963099631 0.0572302867984016 0.318131706567925 GO:1901681 sulfur compound binding 32/1626 275/18639 0.116363636363636 1.33388795706139 0.0573330401610259 0.318131706567925 GO:0001222 transcription corepressor binding 8/1626 49/18639 0.163265306122449 1.87152647036674 0.0600221203259342 0.324673242359891 GO:0015296 monoatomic anion:monoatomic cation symporter activity 5/1626 25/18639 0.2 2.29261992619926 0.0614091367555018 0.324673242359891 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 7/1626 41/18639 0.170731707317073 1.95711457114571 0.0621644875529478 0.324673242359891 GO:0061980 regulatory RNA binding 9/1626 58/18639 0.155172413793103 1.77875683929253 0.062736212203438 0.324673242359891 GO:0030414 peptidase inhibitor activity 21/1626 169/18639 0.124260355029586 1.42440882988712 0.0627637927266477 0.324673242359891 GO:0019239 deaminase activity 6/1626 33/18639 0.181818181818182 2.08419993290842 0.0630288298428537 0.324673242359891 GO:0019956 chemokine binding 6/1626 33/18639 0.181818181818182 2.08419993290842 0.0630288298428537 0.324673242359891 GO:0140311 protein sequestering activity 6/1626 33/18639 0.181818181818182 2.08419993290842 0.0630288298428537 0.324673242359891 GO:0140416 transcription regulator inhibitor activity 6/1626 33/18639 0.181818181818182 2.08419993290842 0.0630288298428537 0.324673242359891 GO:0003953 NAD+ nucleosidase activity 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0010854 adenylate cyclase regulator activity 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0019206 nucleoside kinase activity 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0034713 type I transforming growth factor beta receptor binding 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0047676 arachidonate-CoA ligase activity 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0048185 activin binding 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0048407 platelet-derived growth factor binding 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0097493 structural molecule activity conferring elasticity 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0140537 transcription regulator activator activity 3/1626 11/18639 0.272727272727273 3.12629989936263 0.0642982914354852 0.324673242359891 GO:0001217 DNA-binding transcription repressor activity 32/1626 278/18639 0.115107913669065 1.31949348270461 0.0644992107621913 0.324673242359891 GO:0003746 translation elongation factor activity 4/1626 18/18639 0.222222222222222 2.54735547355474 0.06574944117076 0.328197001325174 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/1626 18/18639 0.222222222222222 2.54735547355474 0.06574944117076 0.328197001325174 GO:0005179 hormone activity 17/1626 132/18639 0.128787878787879 1.47630828581013 0.0671646045815544 0.333864055274143 GO:0004866 endopeptidase inhibitor activity 20/1626 161/18639 0.124223602484472 1.42398753180078 0.068226206599143 0.337733877480405 GO:0035198 miRNA binding 7/1626 42/18639 0.166666666666667 1.91051660516605 0.0692366240527198 0.340363912041015 GO:0106310 protein serine kinase activity 40/1626 361/18639 0.110803324099723 1.2701495436007 0.0693281061407935 0.340363912041015 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/1626 26/18639 0.192307692307692 2.20444223673006 0.070798672929265 0.341954723905316 GO:0008198 ferrous iron binding 5/1626 26/18639 0.192307692307692 2.20444223673006 0.070798672929265 0.341954723905316 GO:0070006 metalloaminopeptidase activity 5/1626 26/18639 0.192307692307692 2.20444223673006 0.070798672929265 0.341954723905316 GO:0070412 R-SMAD binding 5/1626 26/18639 0.192307692307692 2.20444223673006 0.070798672929265 0.341954723905316 GO:0008081 phosphoric diester hydrolase activity 12/1626 87/18639 0.137931034482759 1.58111719048225 0.0746635986826986 0.35916803721153 GO:0005346 purine ribonucleotide transmembrane transporter activity 4/1626 19/18639 0.210526315789474 2.41328413284133 0.0777598318490541 0.3616040524672 GO:0015245 fatty acid transmembrane transporter activity 4/1626 19/18639 0.210526315789474 2.41328413284133 0.0777598318490541 0.3616040524672 GO:0046527 glucosyltransferase activity 4/1626 19/18639 0.210526315789474 2.41328413284133 0.0777598318490541 0.3616040524672 GO:0005025 transforming growth factor beta receptor activity, type I 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0005026 transforming growth factor beta receptor activity, type II 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0005527 macrolide binding 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0008603 cAMP-dependent protein kinase regulator activity 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0010853 cyclase activator activity 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0016361 activin receptor activity, type I 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0016362 activin receptor activity, type II 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0017002 activin receptor activity 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0017166 vinculin binding 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0035251 UDP-glucosyltransferase activity 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0097371 MDM2/MDM4 family protein binding 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/1626 12/18639 0.25 2.86577490774908 0.08034915647586 0.3616040524672 GO:0008237 metallopeptidase activity 22/1626 184/18639 0.119565217391304 1.37058799935825 0.0806944463571785 0.3616040524672 GO:0061135 endopeptidase regulator activity 22/1626 184/18639 0.119565217391304 1.37058799935825 0.0806944463571785 0.3616040524672 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/1626 27/18639 0.185185185185185 2.12279622796228 0.0809289874339835 0.3616040524672 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 5/1626 27/18639 0.185185185185185 2.12279622796228 0.0809289874339835 0.3616040524672 GO:0030020 extracellular matrix structural constituent conferring tensile strength 7/1626 44/18639 0.159090909090909 1.82367494129487 0.0847610419992212 0.377313145914444 GO:0005544 calcium-dependent phospholipid binding 8/1626 53/18639 0.150943396226415 1.73027918958435 0.0871987387676894 0.385289242036494 GO:0016860 intramolecular oxidoreductase activity 8/1626 53/18639 0.150943396226415 1.73027918958435 0.0871987387676894 0.385289242036494 GO:0010851 cyclase regulator activity 4/1626 20/18639 0.2 2.29261992619926 0.0907797693968628 0.387943354248035 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/1626 20/18639 0.2 2.29261992619926 0.0907797693968628 0.387943354248035 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 16/1626 128/18639 0.125 1.43288745387454 0.0911094005456535 0.387943354248035 GO:0035402 histone H3T11 kinase activity 28/1626 247/18639 0.11336032388664 1.29946068691456 0.0916900344485384 0.387943354248035 GO:0045499 chemorepellent activity 5/1626 28/18639 0.178571428571429 2.04698207696363 0.0917853603473008 0.387943354248035 GO:0051393 alpha-actinin binding 5/1626 28/18639 0.178571428571429 2.04698207696363 0.0917853603473008 0.387943354248035 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/1626 28/18639 0.178571428571429 2.04698207696363 0.0917853603473008 0.387943354248035 GO:0001618 virus receptor activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:0033192 calmodulin-dependent protein phosphatase activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:0140791 histone H2AXS140 phosphatase activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:1990439 MAP kinase serine/threonine phosphatase activity 11/1626 81/18639 0.135802469135802 1.556717233839 0.0930023464500738 0.387943354248035 GO:0015485 cholesterol binding 8/1626 54/18639 0.148148148148148 1.69823698236982 0.0949510159884311 0.393321396090966 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 8/1626 54/18639 0.148148148148148 1.69823698236982 0.0949510159884311 0.393321396090966 GO:0005319 lipid transporter activity 21/1626 178/18639 0.117977528089888 1.35238815871305 0.095924470251337 0.395288299049516 GO:0004222 metalloendopeptidase activity 14/1626 110/18639 0.127272727272727 1.45893995303589 0.0972986325518127 0.395288299049516 GO:0004535 poly(A)-specific ribonuclease activity 3/1626 13/18639 0.230769230769231 2.64533068407607 0.0979319497853481 0.395288299049516 GO:0019855 calcium channel inhibitor activity 3/1626 13/18639 0.230769230769231 2.64533068407607 0.0979319497853481 0.395288299049516 GO:0031994 insulin-like growth factor I binding 3/1626 13/18639 0.230769230769231 2.64533068407607 0.0979319497853481 0.395288299049516 GO:0070123 transforming growth factor beta receptor activity, type III 3/1626 13/18639 0.230769230769231 2.64533068407607 0.0979319497853481 0.395288299049516 GO:0140666 annealing activity 3/1626 13/18639 0.230769230769231 2.64533068407607 0.0979319497853481 0.395288299049516 GO:0042277 peptide binding 28/1626 249/18639 0.112449799196787 1.2890232516783 0.0987326989026667 0.395288299049516 GO:0030551 cyclic nucleotide binding 6/1626 37/18639 0.162162162162162 1.85888102124264 0.0988639346698936 0.395288299049516 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 11/1626 82/18639 0.134146341463415 1.53773287732877 0.0994019192915799 0.395288299049516 GO:0033549 MAP kinase phosphatase activity 11/1626 82/18639 0.134146341463415 1.53773287732877 0.0994019192915799 0.395288299049516 GO:0140272 exogenous protein binding 11/1626 82/18639 0.134146341463415 1.53773287732877 0.0994019192915799 0.395288299049516 GO:0008374 O-acyltransferase activity 8/1626 55/18639 0.145454545454545 1.66735994632674 0.103082460279049 0.39844581286959 GO:0043178 alcohol binding 12/1626 92/18639 0.130434782608696 1.49518690839082 0.103296020818107 0.39844581286959 GO:0019842 vitamin binding 18/1626 150/18639 0.12 1.37557195571956 0.103302839239018 0.39844581286959 GO:0004629 phospholipase C activity 5/1626 29/18639 0.172413793103448 1.97639648810281 0.103347952636635 0.39844581286959 GO:0000287 magnesium ion binding 26/1626 230/18639 0.11304347826087 1.29582865393871 0.103498072195545 0.39844581286959 GO:0016853 isomerase activity 21/1626 180/18639 0.116666666666667 1.33736162361624 0.104585352016667 0.39844581286959 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/1626 21/18639 0.19047619047619 2.1834475487612 0.104762947775692 0.39844581286959 GO:0008373 sialyltransferase activity 4/1626 21/18639 0.19047619047619 2.1834475487612 0.104762947775692 0.39844581286959 GO:0010314 phosphatidylinositol-5-phosphate binding 4/1626 21/18639 0.19047619047619 2.1834475487612 0.104762947775692 0.39844581286959 GO:0019200 carbohydrate kinase activity 4/1626 21/18639 0.19047619047619 2.1834475487612 0.104762947775692 0.39844581286959 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/1626 21/18639 0.19047619047619 2.1834475487612 0.104762947775692 0.39844581286959 GO:0051010 microtubule plus-end binding 4/1626 21/18639 0.19047619047619 2.1834475487612 0.104762947775692 0.39844581286959 GO:0061891 calcium ion sensor activity 4/1626 21/18639 0.19047619047619 2.1834475487612 0.104762947775692 0.39844581286959 GO:0019787 ubiquitin-like protein transferase activity 50/1626 479/18639 0.104384133611691 1.19656572348604 0.104871739514712 0.39844581286959 GO:0015631 tubulin binding 41/1626 385/18639 0.106493506493506 1.22074567498922 0.105696046020556 0.399131954942547 GO:0001540 amyloid-beta binding 11/1626 83/18639 0.132530120481928 1.51920597519228 0.10605601820351 0.399131954942547 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 11/1626 83/18639 0.132530120481928 1.51920597519228 0.10605601820351 0.399131954942547 GO:0043022 ribosome binding 14/1626 112/18639 0.125 1.43288745387454 0.108661076610071 0.407077310697895 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 21/1626 181/18639 0.116022099447514 1.32997288536421 0.109094711089472 0.407077310697895 GO:0004842 ubiquitin-protein transferase activity 47/1626 449/18639 0.10467706013363 1.1999235693916 0.109190896415194 0.407077310697895 GO:0043495 protein-membrane adaptor activity 7/1626 47/18639 0.148936170212766 1.70727015780796 0.111450888083601 0.413408091568185 GO:0170055 lipid transmembrane transporter activity 8/1626 56/18639 0.142857142857143 1.6375856615709 0.111588539221178 0.413408091568185 GO:0016791 phosphatase activity 30/1626 273/18639 0.10989010989011 1.25968127813146 0.111928594783339 0.413408091568185 GO:0017018 myosin phosphatase activity 11/1626 84/18639 0.130952380952381 1.50112018977333 0.11296317258725 0.415941558322806 GO:0008083 growth factor activity 19/1626 162/18639 0.117283950617284 1.34443761104278 0.113651360823511 0.417187918345994 GO:0001965 G-protein alpha-subunit binding 5/1626 30/18639 0.166666666666667 1.91051660516605 0.115592271888009 0.420431647446324 GO:0015215 nucleotide transmembrane transporter activity 5/1626 30/18639 0.166666666666667 1.91051660516605 0.115592271888009 0.420431647446324 GO:0070566 adenylyltransferase activity 5/1626 30/18639 0.166666666666667 1.91051660516605 0.115592271888009 0.420431647446324 GO:0042562 hormone binding 12/1626 94/18639 0.127659574468085 1.46337442097825 0.116351359465722 0.421337873415152 GO:0008494 translation activator activity 3/1626 14/18639 0.214285714285714 2.45637849235635 0.116900952305461 0.421337873415152 GO:0098821 BMP receptor activity 3/1626 14/18639 0.214285714285714 2.45637849235635 0.116900952305461 0.421337873415152 GO:0003774 cytoskeletal motor activity 18/1626 153/18639 0.117647058823529 1.3485999565878 0.118509480976203 0.42484791395387 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 50/1626 484/18639 0.103305785123967 1.18420450733433 0.118913442696482 0.42484791395387 GO:0005126 cytokine receptor binding 30/1626 275/18639 0.109090909090909 1.25051995974505 0.119601863413431 0.42484791395387 GO:0015377 chloride:monoatomic cation symporter activity 4/1626 22/18639 0.181818181818182 2.08419993290842 0.119655405774099 0.42484791395387 GO:0140517 protein-RNA adaptor activity 4/1626 22/18639 0.181818181818182 2.08419993290842 0.119655405774099 0.42484791395387 GO:0016755 aminoacyltransferase activity 51/1626 496/18639 0.102822580645161 1.17866548625164 0.123050496282739 0.435606059540971 GO:0017022 myosin binding 10/1626 76/18639 0.131578947368421 1.50830258302583 0.123720280825613 0.436681346227682 GO:0050660 flavin adenine dinucleotide binding 11/1626 86/18639 0.127906976744186 1.46621041791813 0.127527694066639 0.445678087285493 GO:0005164 tumor necrosis factor receptor binding 5/1626 31/18639 0.161290322580645 1.84888703725747 0.128489659965882 0.445678087285493 GO:0017147 Wnt-protein binding 5/1626 31/18639 0.161290322580645 1.84888703725747 0.128489659965882 0.445678087285493 GO:0070273 phosphatidylinositol-4-phosphate binding 5/1626 31/18639 0.161290322580645 1.84888703725747 0.128489659965882 0.445678087285493 GO:0035254 glutamate receptor binding 7/1626 49/18639 0.142857142857143 1.6375856615709 0.131429264024582 0.445678087285493 GO:0030331 nuclear estrogen receptor binding 6/1626 40/18639 0.15 1.71946494464945 0.131472915914835 0.445678087285493 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 29/1626 268/18639 0.108208955223881 1.24041003469736 0.13321627302351 0.445678087285493 GO:0044325 transmembrane transporter binding 16/1626 136/18639 0.117647058823529 1.3485999565878 0.134980624345824 0.445678087285493 GO:0000295 adenine nucleotide transmembrane transporter activity 4/1626 23/18639 0.173913043478261 1.9935825445211 0.135396935505059 0.445678087285493 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/1626 23/18639 0.173913043478261 1.9935825445211 0.135396935505059 0.445678087285493 GO:0016493 C-C chemokine receptor activity 4/1626 23/18639 0.173913043478261 1.9935825445211 0.135396935505059 0.445678087285493 GO:0017134 fibroblast growth factor binding 4/1626 23/18639 0.173913043478261 1.9935825445211 0.135396935505059 0.445678087285493 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/1626 23/18639 0.173913043478261 1.9935825445211 0.135396935505059 0.445678087285493 GO:0099186 structural constituent of postsynapse 4/1626 23/18639 0.173913043478261 1.9935825445211 0.135396935505059 0.445678087285493 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 4/1626 23/18639 0.173913043478261 1.9935825445211 0.135396935505059 0.445678087285493 GO:0032934 sterol binding 9/1626 68/18639 0.132352941176471 1.51717495116128 0.135736661761951 0.445678087285493 GO:0004679 AMP-activated protein kinase activity 27/1626 248/18639 0.108870967741935 1.24799875014879 0.136162705801756 0.445678087285493 GO:0004467 long-chain fatty acid-CoA ligase activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0005523 tropomyosin binding 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0015929 hexosaminidase activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0031005 filamin binding 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0031386 protein tag activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0047372 monoacylglycerol lipase activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0140161 monocarboxylate:sodium symporter activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0141047 molecular tag activity 3/1626 15/18639 0.2 2.29261992619926 0.13710298242563 0.445678087285493 GO:0001786 phosphatidylserine binding 8/1626 59/18639 0.135593220338983 1.5543185940334 0.139289099250744 0.451554063603634 GO:0001216 DNA-binding transcription activator activity 50/1626 491/18639 0.10183299389002 1.16732175468394 0.140527253083908 0.453089004527314 GO:0015106 bicarbonate transmembrane transporter activity 5/1626 32/18639 0.15625 1.79110931734317 0.142007792090743 0.453089004527314 GO:0022884 macromolecule transmembrane transporter activity 5/1626 32/18639 0.15625 1.79110931734317 0.142007792090743 0.453089004527314 GO:0051059 NF-kappaB binding 5/1626 32/18639 0.15625 1.79110931734317 0.142007792090743 0.453089004527314 GO:0015605 organophosphate ester transmembrane transporter activity 7/1626 50/18639 0.14 1.60483394833948 0.142041314076459 0.453089004527314 GO:0032813 tumor necrosis factor receptor superfamily binding 7/1626 50/18639 0.14 1.60483394833948 0.142041314076459 0.453089004527314 GO:0001727 lipid kinase activity 6/1626 41/18639 0.146341463414634 1.67752677526775 0.143354360776873 0.454845086188323 GO:0042287 MHC protein binding 6/1626 41/18639 0.146341463414634 1.67752677526775 0.143354360776873 0.454845086188323 GO:0046943 carboxylic acid transmembrane transporter activity 21/1626 188/18639 0.111702127659574 1.28045261835597 0.143986993699238 0.455640539743212 GO:0005096 GTPase activator activity 29/1626 271/18639 0.107011070110701 1.2266785582985 0.146394244923828 0.462032630143191 GO:0098531 ligand-modulated transcription factor activity 8/1626 60/18639 0.133333333333333 1.52841328413284 0.149221894103089 0.469165689941728 GO:0005342 organic acid transmembrane transporter activity 21/1626 189/18639 0.111111111111111 1.27367773677737 0.149440873577415 0.469165689941728 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/1626 24/18639 0.166666666666667 1.91051660516605 0.151922413034342 0.471988121744714 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/1626 24/18639 0.166666666666667 1.91051660516605 0.151922413034342 0.471988121744714 GO:0005540 hyaluronic acid binding 4/1626 24/18639 0.166666666666667 1.91051660516605 0.151922413034342 0.471988121744714 GO:0030215 semaphorin receptor binding 4/1626 24/18639 0.166666666666667 1.91051660516605 0.151922413034342 0.471988121744714 GO:0003712 transcription coregulator activity 50/1626 495/18639 0.101010101010101 1.15788885161579 0.153900457696711 0.476891548135523 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/1626 16/18639 0.1875 2.14933118081181 0.158381649782451 0.483246312507579 GO:0015378 sodium:chloride symporter activity 3/1626 16/18639 0.1875 2.14933118081181 0.158381649782451 0.483246312507579 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/1626 16/18639 0.1875 2.14933118081181 0.158381649782451 0.483246312507579 GO:0022841 potassium ion leak channel activity 3/1626 16/18639 0.1875 2.14933118081181 0.158381649782451 0.483246312507579 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/1626 16/18639 0.1875 2.14933118081181 0.158381649782451 0.483246312507579 GO:0070411 I-SMAD binding 3/1626 16/18639 0.1875 2.14933118081181 0.158381649782451 0.483246312507579 GO:0015026 coreceptor activity 8/1626 61/18639 0.131147540983607 1.50335732865525 0.159487296215068 0.48537842955249 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 26/1626 243/18639 0.106995884773663 1.22650448726709 0.161925006287258 0.491543339696436 GO:0051427 hormone receptor binding 5/1626 34/18639 0.147058823529412 1.68574994573475 0.170761658835188 0.500098252774058 GO:0004676 3-phosphoinositide-dependent protein kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0004711 ribosomal protein S6 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0035175 histone H3S10 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0035979 histone H2AXS139 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0044022 histone H3S28 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0044023 histone H4S1 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0044024 histone H2AS1 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0044025 histone H2BS14 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0072354 histone H3T3 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0072371 histone H2AS121 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0072518 Rho-dependent protein serine/threonine kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0140823 histone H2BS36 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0140855 histone H3S57 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0140995 histone H2A kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0140997 histone H4 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:0140998 histone H2B kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:1990244 histone H2AT120 kinase activity 26/1626 245/18639 0.106122448979592 1.21649220573838 0.172288668809839 0.500098252774058 GO:1901505 carbohydrate derivative transmembrane transporter activity 7/1626 53/18639 0.132075471698113 1.5139942908863 0.176194306664358 0.510193708375192 GO:0008238 exopeptidase activity 12/1626 102/18639 0.117647058823529 1.3485999565878 0.177352730826175 0.510553480868097 GO:0004677 DNA-dependent protein kinase activity 26/1626 246/18639 0.105691056910569 1.21154711547115 0.17760242628689 0.510553480868097 GO:0140857 histone H3T45 kinase activity 26/1626 246/18639 0.105691056910569 1.21154711547115 0.17760242628689 0.510553480868097 GO:0004549 tRNA-specific ribonuclease activity 3/1626 17/18639 0.176470588235294 2.0228999348817 0.180580764245577 0.511716987517752 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/1626 17/18639 0.176470588235294 2.0228999348817 0.180580764245577 0.511716987517752 GO:0017110 nucleoside diphosphate phosphatase activity 3/1626 17/18639 0.176470588235294 2.0228999348817 0.180580764245577 0.511716987517752 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/1626 17/18639 0.176470588235294 2.0228999348817 0.180580764245577 0.511716987517752 GO:0051787 misfolded protein binding 3/1626 17/18639 0.176470588235294 2.0228999348817 0.180580764245577 0.511716987517752 GO:0070403 NAD+ binding 3/1626 17/18639 0.176470588235294 2.0228999348817 0.180580764245577 0.511716987517752 GO:0035403 histone H3T6 kinase activity 26/1626 247/18639 0.105263157894737 1.20664206642066 0.183002756043165 0.517351393268949 GO:0061630 ubiquitin protein ligase activity 36/1626 353/18639 0.101983002832861 1.16904132214127 0.183633812264756 0.517743916595677 GO:0005343 organic acid:sodium symporter activity 5/1626 35/18639 0.142857142857143 1.6375856615709 0.185918888866463 0.517743916595677 GO:0061631 ubiquitin conjugating enzyme activity 5/1626 35/18639 0.142857142857143 1.6375856615709 0.185918888866463 0.517743916595677 GO:0001637 G protein-coupled chemoattractant receptor activity 4/1626 26/18639 0.153846153846154 1.76355378938405 0.187047466934398 0.517743916595677 GO:0004435 phosphatidylinositol phospholipase C activity 4/1626 26/18639 0.153846153846154 1.76355378938405 0.187047466934398 0.517743916595677 GO:0004950 chemokine receptor activity 4/1626 26/18639 0.153846153846154 1.76355378938405 0.187047466934398 0.517743916595677 GO:0015145 monosaccharide transmembrane transporter activity 4/1626 26/18639 0.153846153846154 1.76355378938405 0.187047466934398 0.517743916595677 GO:0015216 purine nucleotide transmembrane transporter activity 4/1626 26/18639 0.153846153846154 1.76355378938405 0.187047466934398 0.517743916595677 GO:0052742 phosphatidylinositol kinase activity 4/1626 26/18639 0.153846153846154 1.76355378938405 0.187047466934398 0.517743916595677 GO:0051117 ATPase binding 10/1626 84/18639 0.119047619047619 1.36465471797575 0.195153134470835 0.535753318518981 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/1626 45/18639 0.133333333333333 1.52841328413284 0.195350120331732 0.535753318518981 GO:0042605 peptide antigen binding 6/1626 45/18639 0.133333333333333 1.52841328413284 0.195350120331732 0.535753318518981 GO:0140303 intramembrane lipid transporter activity 6/1626 45/18639 0.133333333333333 1.52841328413284 0.195350120331732 0.535753318518981 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/1626 36/18639 0.138888888888889 1.59209717097171 0.201540803884287 0.544671703614239 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/1626 36/18639 0.138888888888889 1.59209717097171 0.201540803884287 0.544671703614239 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/1626 36/18639 0.138888888888889 1.59209717097171 0.201540803884287 0.544671703614239 GO:0004706 JUN kinase kinase kinase activity 3/1626 18/18639 0.166666666666667 1.91051660516605 0.20354702886054 0.544671703614239 GO:0008525 phosphatidylcholine transporter activity 3/1626 18/18639 0.166666666666667 1.91051660516605 0.20354702886054 0.544671703614239 GO:0015172 acidic amino acid transmembrane transporter activity 3/1626 18/18639 0.166666666666667 1.91051660516605 0.20354702886054 0.544671703614239 GO:0015373 monoatomic anion:sodium symporter activity 3/1626 18/18639 0.166666666666667 1.91051660516605 0.20354702886054 0.544671703614239 GO:0016854 racemase and epimerase activity 3/1626 18/18639 0.166666666666667 1.91051660516605 0.20354702886054 0.544671703614239 GO:0034185 apolipoprotein binding 3/1626 18/18639 0.166666666666667 1.91051660516605 0.20354702886054 0.544671703614239 GO:0019843 rRNA binding 8/1626 65/18639 0.123076923076923 1.41084303150724 0.203624123899372 0.544671703614239 GO:0038024 cargo receptor activity 8/1626 65/18639 0.123076923076923 1.41084303150724 0.203624123899372 0.544671703614239 GO:0004867 serine-type endopeptidase inhibitor activity 11/1626 95/18639 0.115789473684211 1.32730627306273 0.204630587868871 0.544810901390235 GO:0005044 scavenger receptor activity 4/1626 27/18639 0.148148148148148 1.69823698236982 0.205502854673601 0.544810901390235 GO:0008266 poly(U) RNA binding 4/1626 27/18639 0.148148148148148 1.69823698236982 0.205502854673601 0.544810901390235 GO:0016405 CoA-ligase activity 4/1626 27/18639 0.148148148148148 1.69823698236982 0.205502854673601 0.544810901390235 GO:0140789 histone phosphatase activity 15/1626 136/18639 0.110294117647059 1.26431245930106 0.206271344891652 0.545635730500535 GO:0000149 SNARE binding 12/1626 106/18639 0.113207547169811 1.29770939218826 0.212663660380396 0.546730243600213 GO:0008013 beta-catenin binding 12/1626 106/18639 0.113207547169811 1.29770939218826 0.212663660380396 0.546730243600213 GO:0030170 pyridoxal phosphate binding 7/1626 56/18639 0.125 1.43288745387454 0.213454332393829 0.546730243600213 GO:0004090 carbonyl reductase (NADPH) activity 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0004382 GDP phosphatase activity 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0004955 prostaglandin receptor activity 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0008140 cAMP response element binding protein binding 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0008190 eukaryotic initiation factor 4E binding 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0008401 retinoic acid 4-hydroxylase activity 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0016868 intramolecular phosphotransferase activity 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0019911 structural constituent of myelin sheath 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0033204 ribonuclease P RNA binding 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0035256 G protein-coupled glutamate receptor binding 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0035374 chondroitin sulfate binding 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0043208 glycosphingolipid binding 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0140999 histone H3K4 trimethyltransferase activity 2/1626 10/18639 0.2 2.29261992619926 0.214934186293797 0.546730243600213 GO:0023023 MHC protein complex binding 5/1626 37/18639 0.135135135135135 1.5490675177022 0.217584064699036 0.552293168480744 GO:1990782 protein tyrosine kinase binding 13/1626 117/18639 0.111111111111111 1.27367773677737 0.219545884758316 0.556089682625628 GO:0061659 ubiquitin-like protein ligase activity 37/1626 372/18639 0.0994623655913978 1.14014700630877 0.222980882209038 0.558698204251818 GO:0051019 mitogen-activated protein kinase binding 4/1626 28/18639 0.142857142857143 1.6375856615709 0.224455770394651 0.558698204251818 GO:0051119 sugar transmembrane transporter activity 4/1626 28/18639 0.142857142857143 1.6375856615709 0.224455770394651 0.558698204251818 GO:0097718 disordered domain specific binding 4/1626 28/18639 0.142857142857143 1.6375856615709 0.224455770394651 0.558698204251818 GO:0015932 nucleobase-containing compound transmembrane transporter activity 7/1626 57/18639 0.12280701754386 1.40774907749077 0.226473069096907 0.558698204251818 GO:0070279 vitamin B6 binding 7/1626 57/18639 0.12280701754386 1.40774907749077 0.226473069096907 0.558698204251818 GO:0005520 insulin-like growth factor binding 3/1626 19/18639 0.157894736842105 1.809963099631 0.227132128300194 0.558698204251818 GO:0008381 mechanosensitive monoatomic ion channel activity 3/1626 19/18639 0.157894736842105 1.809963099631 0.227132128300194 0.558698204251818 GO:0008574 plus-end-directed microtubule motor activity 3/1626 19/18639 0.157894736842105 1.809963099631 0.227132128300194 0.558698204251818 GO:0022840 leak channel activity 3/1626 19/18639 0.157894736842105 1.809963099631 0.227132128300194 0.558698204251818 GO:0022842 narrow pore channel activity 3/1626 19/18639 0.157894736842105 1.809963099631 0.227132128300194 0.558698204251818 GO:0034987 immunoglobulin receptor binding 3/1626 19/18639 0.157894736842105 1.809963099631 0.227132128300194 0.558698204251818 GO:0046624 sphingolipid transporter activity 3/1626 19/18639 0.157894736842105 1.809963099631 0.227132128300194 0.558698204251818 GO:0070003 threonine-type peptidase activity 3/1626 19/18639 0.157894736842105 1.809963099631 0.227132128300194 0.558698204251818 GO:0005501 retinoid binding 5/1626 38/18639 0.131578947368421 1.50830258302583 0.23400447671098 0.57094787164802 GO:0019840 isoprenoid binding 5/1626 38/18639 0.131578947368421 1.50830258302583 0.23400447671098 0.57094787164802 GO:0043531 ADP binding 5/1626 38/18639 0.131578947368421 1.50830258302583 0.23400447671098 0.57094787164802 GO:0004725 protein tyrosine phosphatase activity 11/1626 98/18639 0.112244897959184 1.28667444837714 0.234026411765198 0.57094787164802 GO:0005548 phospholipid transporter activity 8/1626 68/18639 0.117647058823529 1.3485999565878 0.239551594669014 0.574089676196897 GO:0008408 3'-5' exonuclease activity 7/1626 58/18639 0.120689655172414 1.38347754167197 0.239755688529984 0.574089676196897 GO:0016298 lipase activity 14/1626 130/18639 0.107692307692308 1.23448765256883 0.242944154909067 0.574089676196897 GO:0003727 single-stranded RNA binding 10/1626 89/18639 0.112359550561798 1.28798872258386 0.247174494181699 0.574089676196897 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 10/1626 89/18639 0.112359550561798 1.28798872258386 0.247174494181699 0.574089676196897 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 10/1626 89/18639 0.112359550561798 1.28798872258386 0.247174494181699 0.574089676196897 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0002162 dystroglycan binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0004954 prostanoid receptor activity 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0005225 volume-sensitive anion channel activity 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0008046 axon guidance receptor activity 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0008199 ferric iron binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0015173 aromatic amino acid transmembrane transporter activity 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0019215 intermediate filament binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0032050 clathrin heavy chain binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0034511 U3 snoRNA binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0045294 alpha-catenin binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0050786 RAGE receptor binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0050998 nitric-oxide synthase binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0070697 activin receptor binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0140031 phosphorylation-dependent protein binding 2/1626 11/18639 0.181818181818182 2.08419993290842 0.248408829595645 0.574089676196897 GO:0015370 solute:sodium symporter activity 9/1626 79/18639 0.113924050632911 1.30592274277173 0.249841950147173 0.574089676196897 GO:0033293 monocarboxylic acid binding 9/1626 79/18639 0.113924050632911 1.30592274277173 0.249841950147173 0.574089676196897 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/1626 39/18639 0.128205128205128 1.46962815782004 0.250757381593683 0.574089676196897 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/1626 39/18639 0.128205128205128 1.46962815782004 0.250757381593683 0.574089676196897 GO:0000339 RNA cap binding 3/1626 20/18639 0.15 1.71946494464945 0.251194309283135 0.574089676196897 GO:0016505 peptidase activator activity involved in apoptotic process 3/1626 20/18639 0.15 1.71946494464945 0.251194309283135 0.574089676196897 GO:0042288 MHC class I protein binding 3/1626 20/18639 0.15 1.71946494464945 0.251194309283135 0.574089676196897 GO:0002039 p53 binding 8/1626 69/18639 0.115942028985507 1.32905502968073 0.251980453396032 0.574785240729382 GO:0004879 nuclear receptor activity 7/1626 59/18639 0.11864406779661 1.36002876977922 0.253280037086805 0.575548731894397 GO:0070888 E-box binding 7/1626 59/18639 0.11864406779661 1.36002876977922 0.253280037086805 0.575548731894397 GO:0004540 RNA nuclease activity 13/1626 121/18639 0.107438016528926 1.2315726876277 0.256189641718435 0.581053693099036 GO:0140793 histone H2AXY142 phosphatase activity 10/1626 90/18639 0.111111111111111 1.27367773677737 0.258126109500486 0.584334817142467 GO:0008187 poly-pyrimidine tract binding 4/1626 30/18639 0.133333333333333 1.52841328413284 0.26356236728946 0.593263970144012 GO:0051721 protein phosphatase 2A binding 4/1626 30/18639 0.133333333333333 1.52841328413284 0.26356236728946 0.593263970144012 GO:0098918 structural constituent of synapse 4/1626 30/18639 0.133333333333333 1.52841328413284 0.26356236728946 0.593263970144012 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13/1626 122/18639 0.10655737704918 1.22147782953239 0.265681219556621 0.596907146762803 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/1626 60/18639 0.116666666666667 1.33736162361624 0.267023565405409 0.598282841424213 GO:0015144 carbohydrate transmembrane transporter activity 5/1626 40/18639 0.125 1.43288745387454 0.267798019547804 0.598282841424213 GO:0071855 neuropeptide receptor binding 5/1626 40/18639 0.125 1.43288745387454 0.267798019547804 0.598282841424213 GO:0005506 iron ion binding 16/1626 154/18639 0.103896103896104 1.19097139023338 0.268457066533913 0.598634168925155 GO:0030971 receptor tyrosine kinase binding 9/1626 81/18639 0.111111111111111 1.27367773677737 0.273440080636696 0.601951611018076 GO:0015171 amino acid transmembrane transporter activity 11/1626 102/18639 0.107843137254902 1.23621662687215 0.275498361271437 0.601951611018076 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/1626 21/18639 0.142857142857143 1.6375856615709 0.275599536201042 0.601951611018076 GO:0036122 BMP binding 3/1626 21/18639 0.142857142857143 1.6375856615709 0.275599536201042 0.601951611018076 GO:0017171 serine hydrolase activity 20/1626 198/18639 0.101010101010101 1.15788885161579 0.278574085054268 0.601951611018076 GO:0004175 endopeptidase activity 39/1626 405/18639 0.0962962962962963 1.10385403854039 0.280908588959006 0.601951611018076 GO:0000340 RNA 7-methylguanosine cap binding 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0004000 adenosine deaminase activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0004526 ribonuclease P activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0004859 phospholipase inhibitor activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0015132 prostaglandin transmembrane transporter activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0016208 AMP binding 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0016840 carbon-nitrogen lyase activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0035497 cAMP response element binding 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0042301 phosphate ion binding 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0045295 gamma-catenin binding 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0070008 serine-type exopeptidase activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0070410 co-SMAD binding 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0097677 STAT family protein binding 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/1626 12/18639 0.166666666666667 1.91051660516605 0.282020764219601 0.601951611018076 GO:0043021 ribonucleoprotein complex binding 18/1626 177/18639 0.101694915254237 1.16573894552505 0.282251099478235 0.601951611018076 GO:0016411 acylglycerol O-acyltransferase activity 4/1626 31/18639 0.129032258064516 1.47910962980598 0.283573138744805 0.601951611018076 GO:0016878 acid-thiol ligase activity 4/1626 31/18639 0.129032258064516 1.47910962980598 0.283573138744805 0.601951611018076 GO:0015175 neutral L-amino acid transmembrane transporter activity 5/1626 41/18639 0.121951219512195 1.39793897938979 0.285081861043766 0.601951611018076 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/1626 41/18639 0.121951219512195 1.39793897938979 0.285081861043766 0.601951611018076 GO:0042169 SH2 domain binding 5/1626 41/18639 0.121951219512195 1.39793897938979 0.285081861043766 0.601951611018076 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/1626 41/18639 0.121951219512195 1.39793897938979 0.285081861043766 0.601951611018076 GO:0004722 protein serine/threonine phosphatase activity 11/1626 103/18639 0.106796116504854 1.22421452369864 0.286210793013324 0.603267625556353 GO:0030165 PDZ domain binding 9/1626 83/18639 0.108433734939759 1.2429867069755 0.297651571048421 0.62627570416361 GO:0033691 sialic acid binding 3/1626 22/18639 0.136363636363636 1.56314994968131 0.300222293636876 0.630572528712663 GO:0016859 cis-trans isomerase activity 5/1626 42/18639 0.119047619047619 1.36465471797575 0.30256490755001 0.632512276294231 GO:0030515 snoRNA binding 4/1626 32/18639 0.125 1.43288745387454 0.303796759695385 0.632512276294231 GO:0071813 lipoprotein particle binding 4/1626 32/18639 0.125 1.43288745387454 0.303796759695385 0.632512276294231 GO:0071814 protein-lipid complex binding 4/1626 32/18639 0.125 1.43288745387454 0.303796759695385 0.632512276294231 GO:0120015 sterol transfer activity 4/1626 32/18639 0.125 1.43288745387454 0.303796759695385 0.632512276294231 GO:0003713 transcription coactivator activity 25/1626 256/18639 0.09765625 1.11944332333948 0.306386096131235 0.636792008161261 GO:0005507 copper ion binding 7/1626 63/18639 0.111111111111111 1.27367773677737 0.309340363399387 0.637934422202459 GO:0180051 translation factor activity 9/1626 84/18639 0.107142857142857 1.22818924617818 0.309951383437732 0.637934422202459 GO:0017046 peptide hormone binding 6/1626 53/18639 0.113207547169811 1.29770939218826 0.315016405476013 0.637934422202459 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0008035 high-density lipoprotein particle binding 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0008253 5'-nucleotidase activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0030955 potassium ion binding 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0031432 titin binding 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0035673 oligopeptide transmembrane transporter activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0043560 insulin receptor substrate binding 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0046975 histone H3K36 methyltransferase activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0071714 icosanoid transmembrane transporter activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0140333 glycerophospholipid flippase activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0140852 histone ubiquitin ligase activity 2/1626 13/18639 0.153846153846154 1.76355378938405 0.315491457753102 0.637934422202459 GO:0033218 amide binding 24/1626 247/18639 0.097165991902834 1.11382344592677 0.32007222607975 0.64527588810301 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/1626 43/18639 0.116279069767442 1.33291856174376 0.32020396123804 0.64527588810301 GO:0022804 active transmembrane transporter activity 43/1626 457/18639 0.0940919037199125 1.07858486681147 0.32294484327223 0.648262030345286 GO:0030296 protein tyrosine kinase activator activity 4/1626 33/18639 0.121212121212121 1.38946662193895 0.324167184728343 0.648262030345286 GO:0004602 glutathione peroxidase activity 3/1626 23/18639 0.130434782608696 1.49518690839082 0.324946097356648 0.648262030345286 GO:0005158 insulin receptor binding 3/1626 23/18639 0.130434782608696 1.49518690839082 0.324946097356648 0.648262030345286 GO:0005283 amino acid:sodium symporter activity 3/1626 23/18639 0.130434782608696 1.49518690839082 0.324946097356648 0.648262030345286 GO:0016849 phosphorus-oxygen lyase activity 3/1626 23/18639 0.130434782608696 1.49518690839082 0.324946097356648 0.648262030345286 GO:0070851 growth factor receptor binding 14/1626 139/18639 0.100719424460432 1.15455679736653 0.326991614246711 0.651253749242615 GO:0008236 serine-type peptidase activity 19/1626 194/18639 0.0979381443298969 1.1226747061285 0.33294921342313 0.662014019356323 GO:0001046 core promoter sequence-specific DNA binding 5/1626 44/18639 0.113636363636364 1.30262495806776 0.337956864072446 0.670852810047301 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/1626 34/18639 0.117647058823529 1.3485999565878 0.344621254847431 0.671845533333318 GO:0019825 oxygen binding 4/1626 34/18639 0.117647058823529 1.3485999565878 0.344621254847431 0.671845533333318 GO:0090482 vitamin transmembrane transporter activity 4/1626 34/18639 0.117647058823529 1.3485999565878 0.344621254847431 0.671845533333318 GO:0004705 JUN kinase activity 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0005313 L-glutamate transmembrane transporter activity 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0005347 ATP transmembrane transporter activity 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0008474 palmitoyl-(protein) hydrolase activity 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0032036 myosin heavy chain binding 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0042043 neurexin family protein binding 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0098599 palmitoyl hydrolase activity 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0098847 sequence-specific single stranded DNA binding 2/1626 14/18639 0.142857142857143 1.6375856615709 0.348589875327709 0.671845533333318 GO:0004622 lysophospholipase activity 3/1626 24/18639 0.125 1.43288745387454 0.349663766545549 0.671845533333318 GO:0005315 phosphate transmembrane transporter activity 3/1626 24/18639 0.125 1.43288745387454 0.349663766545549 0.671845533333318 GO:0015149 hexose transmembrane transporter activity 3/1626 24/18639 0.125 1.43288745387454 0.349663766545549 0.671845533333318 GO:0030552 cAMP binding 3/1626 24/18639 0.125 1.43288745387454 0.349663766545549 0.671845533333318 GO:0035035 histone acetyltransferase binding 3/1626 24/18639 0.125 1.43288745387454 0.349663766545549 0.671845533333318 GO:0055056 D-glucose transmembrane transporter activity 3/1626 24/18639 0.125 1.43288745387454 0.349663766545549 0.671845533333318 GO:0005516 calmodulin binding 20/1626 207/18639 0.0966183574879227 1.10754585806728 0.349720097401501 0.671845533333318 GO:0004620 phospholipase activity 11/1626 109/18639 0.100917431192661 1.15682656826568 0.352611852229738 0.67559604457558 GO:0008235 metalloexopeptidase activity 7/1626 66/18639 0.106060606060606 1.21578329419658 0.352804975499234 0.67559604457558 GO:0004721 phosphoprotein phosphatase activity 17/1626 175/18639 0.0971428571428571 1.11355824986821 0.357859698819052 0.684177276748605 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 13/1626 132/18639 0.0984848484848485 1.12894163032539 0.365888698771926 0.698408348215852 GO:0004252 serine-type endopeptidase activity 17/1626 176/18639 0.0965909090909091 1.1072312143576 0.366806709613934 0.699042179823361 GO:0030276 clathrin binding 5/1626 46/18639 0.108695652173913 1.24598909032569 0.373642010553888 0.704279274984585 GO:0004709 MAP kinase kinase kinase activity 3/1626 25/18639 0.12 1.37557195571956 0.374277502380743 0.704279274984585 GO:0015645 fatty acid ligase activity 3/1626 25/18639 0.12 1.37557195571956 0.374277502380743 0.704279274984585 GO:0015662 P-type ion transporter activity 3/1626 25/18639 0.12 1.37557195571956 0.374277502380743 0.704279274984585 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/1626 25/18639 0.12 1.37557195571956 0.374277502380743 0.704279274984585 GO:0120020 cholesterol transfer activity 3/1626 25/18639 0.12 1.37557195571956 0.374277502380743 0.704279274984585 GO:0120515 fatty acid-CoA ligase activity 3/1626 25/18639 0.12 1.37557195571956 0.374277502380743 0.704279274984585 GO:0140358 P-type transmembrane transporter activity 3/1626 25/18639 0.12 1.37557195571956 0.374277502380743 0.704279274984585 GO:0000774 adenyl-nucleotide exchange factor activity 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0004559 alpha-mannosidase activity 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0004953 icosanoid receptor activity 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0008252 nucleotidase activity 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0030553 cGMP binding 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0042809 nuclear vitamin D receptor binding 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0048531 beta-1,3-galactosyltransferase activity 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0120283 protein serine/threonine kinase binding 2/1626 15/18639 0.133333333333333 1.52841328413284 0.381126320389567 0.706030590411107 GO:0003777 microtubule motor activity 7/1626 68/18639 0.102941176470588 1.18002496201433 0.382118818522916 0.706771706198199 GO:0005484 SNAP receptor activity 4/1626 36/18639 0.111111111111111 1.27367773677737 0.385543751440868 0.710902156829916 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/1626 36/18639 0.111111111111111 1.27367773677737 0.385543751440868 0.710902156829916 GO:0140359 ABC-type transporter activity 5/1626 47/18639 0.106382978723404 1.21947868414854 0.391496877291892 0.720765084273498 GO:0046982 protein heterodimerization activity 34/1626 369/18639 0.0921409214092141 1.05622056220562 0.394686626947863 0.725517944451156 GO:0072341 modified amino acid binding 9/1626 91/18639 0.0989010989010989 1.13371315031832 0.3983191735696 0.728403800831461 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1626 26/18639 0.115384615384615 1.32266534203804 0.398698811352006 0.728403800831461 GO:0008157 protein phosphatase 1 binding 3/1626 26/18639 0.115384615384615 1.32266534203804 0.398698811352006 0.728403800831461 GO:0050750 low-density lipoprotein particle receptor binding 3/1626 26/18639 0.115384615384615 1.32266534203804 0.398698811352006 0.728403800831461 GO:0016779 nucleotidyltransferase activity 13/1626 136/18639 0.0955882352941176 1.09573746472759 0.407598999163062 0.737493647050377 GO:0016879 ligase activity, forming carbon-nitrogen bonds 5/1626 48/18639 0.104166666666667 1.19407287822878 0.409311118901562 0.737493647050377 GO:0015101 organic cation transmembrane transporter activity 8/1626 81/18639 0.0987654320987654 1.13215798824655 0.411492218410254 0.737493647050377 GO:0097110 scaffold protein binding 7/1626 70/18639 0.1 1.14630996309963 0.411501246266717 0.737493647050377 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0004707 MAP kinase activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0004708 MAP kinase kinase activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0008142 oxysterol binding 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0015562 efflux transmembrane transporter activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0015923 mannosidase activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0016722 oxidoreductase activity, acting on metal ions 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0022858 alanine transmembrane transporter activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0055102 lipase inhibitor activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0140327 flippase activity 2/1626 16/18639 0.125 1.43288745387454 0.412946987619155 0.737493647050377 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1626 27/18639 0.111111111111111 1.27367773677737 0.422848305936807 0.751800341255754 GO:0008320 protein transmembrane transporter activity 3/1626 27/18639 0.111111111111111 1.27367773677737 0.422848305936807 0.751800341255754 GO:0023026 MHC class II protein complex binding 3/1626 27/18639 0.111111111111111 1.27367773677737 0.422848305936807 0.751800341255754 GO:0000146 microfilament motor activity 4/1626 38/18639 0.105263157894737 1.20664206642066 0.426125798365203 0.755154226890742 GO:0042887 amide transmembrane transporter activity 4/1626 38/18639 0.105263157894737 1.20664206642066 0.426125798365203 0.755154226890742 GO:0008509 monoatomic anion transmembrane transporter activity 14/1626 149/18639 0.0939597315436242 1.07706976398623 0.426633653750511 0.755154226890742 GO:0008135 translation factor activity, RNA binding 8/1626 83/18639 0.0963855421686747 1.10487707286711 0.438711718573789 0.771143132229849 GO:0140767 enzyme-substrate adaptor activity 13/1626 139/18639 0.0935251798561151 1.0720884546975 0.43903658669482 0.771143132229849 GO:0031490 chromatin DNA binding 12/1626 128/18639 0.09375 1.0746655904059 0.441450986486142 0.771143132229849 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0008429 phosphatidylethanolamine binding 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0015278 intracellularly gated calcium channel activity 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0016805 dipeptidase activity 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0030169 low-density lipoprotein particle binding 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0031489 myosin V binding 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0045125 bioactive lipid receptor activity 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0070492 oligosaccharide binding 2/1626 17/18639 0.117647058823529 1.3485999565878 0.443929150735633 0.771143132229849 GO:0005242 inward rectifier potassium channel activity 3/1626 28/18639 0.107142857142857 1.22818924617818 0.446655410201866 0.771143132229849 GO:0016866 intramolecular transferase activity 3/1626 28/18639 0.107142857142857 1.22818924617818 0.446655410201866 0.771143132229849 GO:0019789 SUMO transferase activity 3/1626 28/18639 0.107142857142857 1.22818924617818 0.446655410201866 0.771143132229849 GO:0046625 sphingolipid binding 3/1626 28/18639 0.107142857142857 1.22818924617818 0.446655410201866 0.771143132229849 GO:0046875 ephrin receptor binding 3/1626 28/18639 0.107142857142857 1.22818924617818 0.446655410201866 0.771143132229849 GO:0004527 exonuclease activity 8/1626 84/18639 0.0952380952380952 1.0917237743806 0.452265438061795 0.779700386716361 GO:0015179 L-amino acid transmembrane transporter activity 6/1626 62/18639 0.0967741935483871 1.10933222235448 0.458641938855373 0.789552428650014 GO:0016407 acetyltransferase activity 9/1626 96/18639 0.09375 1.0746655904059 0.462042185542935 0.79334642454928 GO:0016597 amino acid binding 5/1626 51/18639 0.0980392156862745 1.1238332971565 0.462175829892497 0.79334642454928 GO:0050997 quaternary ammonium group binding 4/1626 40/18639 0.1 1.14630996309963 0.465986779093678 0.798738832555686 GO:0005416 amino acid:monoatomic cation symporter activity 3/1626 29/18639 0.103448275862069 1.18583789286169 0.470057993544088 0.800926998232623 GO:0051861 glycolipid binding 3/1626 29/18639 0.103448275862069 1.18583789286169 0.470057993544088 0.800926998232623 GO:0099604 ligand-gated calcium channel activity 3/1626 29/18639 0.103448275862069 1.18583789286169 0.470057993544088 0.800926998232623 GO:0005496 steroid binding 10/1626 108/18639 0.0925925925925926 1.06139811398114 0.470566484842748 0.800926998232623 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1626 18/18639 0.111111111111111 1.27367773677737 0.473976915970018 0.800926998232623 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/1626 18/18639 0.111111111111111 1.27367773677737 0.473976915970018 0.800926998232623 GO:0017075 syntaxin-1 binding 2/1626 18/18639 0.111111111111111 1.27367773677737 0.473976915970018 0.800926998232623 GO:0030228 lipoprotein particle receptor activity 2/1626 18/18639 0.111111111111111 1.27367773677737 0.473976915970018 0.800926998232623 GO:0050811 GABA receptor binding 2/1626 18/18639 0.111111111111111 1.27367773677737 0.473976915970018 0.800926998232623 GO:0070064 proline-rich region binding 2/1626 18/18639 0.111111111111111 1.27367773677737 0.473976915970018 0.800926998232623 GO:0015108 chloride transmembrane transporter activity 11/1626 121/18639 0.0909090909090909 1.04209996645421 0.489436675514626 0.825881122898089 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1626 30/18639 0.1 1.14630996309963 0.493001952016825 0.828382153177566 GO:0031210 phosphatidylcholine binding 3/1626 30/18639 0.1 1.14630996309963 0.493001952016825 0.828382153177566 GO:0031624 ubiquitin conjugating enzyme binding 3/1626 30/18639 0.1 1.14630996309963 0.493001952016825 0.828382153177566 GO:0005246 calcium channel regulator activity 5/1626 53/18639 0.0943396226415094 1.08142449349022 0.496636989100207 0.831812711140776 GO:0003756 protein disulfide isomerase activity 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0005229 intracellularly calcium-gated chloride channel activity 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0031420 alkali metal ion binding 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0042577 lipid phosphatase activity 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0042800 histone H3K4 methyltransferase activity 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0097001 ceramide binding 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0140036 ubiquitin-modified protein reader activity 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0141147 intracellularly calcium-gated channel activity 2/1626 19/18639 0.105263157894737 1.20664206642066 0.503017479225292 0.831812711140776 GO:0004520 DNA endonuclease activity 4/1626 42/18639 0.0952380952380952 1.0917237743806 0.504805031740085 0.831812711140776 GO:0019894 kinesin binding 4/1626 42/18639 0.0952380952380952 1.0917237743806 0.504805031740085 0.831812711140776 GO:0042056 chemoattractant activity 4/1626 42/18639 0.0952380952380952 1.0917237743806 0.504805031740085 0.831812711140776 GO:0043175 RNA polymerase core enzyme binding 4/1626 42/18639 0.0952380952380952 1.0917237743806 0.504805031740085 0.831812711140776 GO:0004197 cysteine-type endopeptidase activity 8/1626 88/18639 0.0909090909090909 1.04209996645421 0.505769590248892 0.832252580919902 GO:0017069 snRNA binding 5/1626 54/18639 0.0925925925925926 1.06139811398114 0.513553349237332 0.840055763459727 GO:0005184 neuropeptide hormone activity 3/1626 31/18639 0.0967741935483871 1.10933222235448 0.515440753438827 0.840055763459727 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/1626 31/18639 0.0967741935483871 1.10933222235448 0.515440753438827 0.840055763459727 GO:0005452 solute:inorganic anion antiporter activity 3/1626 31/18639 0.0967741935483871 1.10933222235448 0.515440753438827 0.840055763459727 GO:0008327 methyl-CpG binding 3/1626 31/18639 0.0967741935483871 1.10933222235448 0.515440753438827 0.840055763459727 GO:0047499 calcium-independent phospholipase A2 activity 3/1626 31/18639 0.0967741935483871 1.10933222235448 0.515440753438827 0.840055763459727 GO:0070325 lipoprotein particle receptor binding 3/1626 31/18639 0.0967741935483871 1.10933222235448 0.515440753438827 0.840055763459727 GO:0008200 ion channel inhibitor activity 4/1626 43/18639 0.0930232558139535 1.06633484939501 0.5237384748685 0.850095238800164 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/1626 43/18639 0.0930232558139535 1.06633484939501 0.5237384748685 0.850095238800164 GO:0048156 tau protein binding 4/1626 43/18639 0.0930232558139535 1.06633484939501 0.5237384748685 0.850095238800164 GO:0005326 neurotransmitter transmembrane transporter activity 2/1626 20/18639 0.1 1.14630996309963 0.530997831441087 0.853747187209188 GO:0015095 magnesium ion transmembrane transporter activity 2/1626 20/18639 0.1 1.14630996309963 0.530997831441087 0.853747187209188 GO:0015464 acetylcholine receptor activity 2/1626 20/18639 0.1 1.14630996309963 0.530997831441087 0.853747187209188 GO:0016004 phospholipase activator activity 2/1626 20/18639 0.1 1.14630996309963 0.530997831441087 0.853747187209188 GO:0043024 ribosomal small subunit binding 2/1626 20/18639 0.1 1.14630996309963 0.530997831441087 0.853747187209188 GO:0052745 inositol phosphate phosphatase activity 2/1626 20/18639 0.1 1.14630996309963 0.530997831441087 0.853747187209188 GO:0140939 histone H4 methyltransferase activity 2/1626 20/18639 0.1 1.14630996309963 0.530997831441087 0.853747187209188 GO:0031369 translation initiation factor binding 3/1626 32/18639 0.09375 1.0746655904059 0.537334959688148 0.860457190480484 GO:0070717 poly-purine tract binding 3/1626 32/18639 0.09375 1.0746655904059 0.537334959688148 0.860457190480484 GO:0160041 neuropeptide activity 3/1626 32/18639 0.09375 1.0746655904059 0.537334959688148 0.860457190480484 GO:0016248 channel inhibitor activity 4/1626 44/18639 0.0909090909090909 1.04209996645421 0.542316635948105 0.86727043791701 GO:0042826 histone deacetylase binding 11/1626 127/18639 0.0866141732283465 0.992866897172909 0.555808887588772 0.883868608214012 GO:0005123 death receptor binding 2/1626 21/18639 0.0952380952380952 1.0917237743806 0.557881862518987 0.883868608214012 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1626 21/18639 0.0952380952380952 1.0917237743806 0.557881862518987 0.883868608214012 GO:0015125 bile acid transmembrane transporter activity 2/1626 21/18639 0.0952380952380952 1.0917237743806 0.557881862518987 0.883868608214012 GO:0015174 basic amino acid transmembrane transporter activity 2/1626 21/18639 0.0952380952380952 1.0917237743806 0.557881862518987 0.883868608214012 GO:0051428 peptide hormone receptor binding 2/1626 21/18639 0.0952380952380952 1.0917237743806 0.557881862518987 0.883868608214012 GO:0140312 cargo adaptor activity 2/1626 21/18639 0.0952380952380952 1.0917237743806 0.557881862518987 0.883868608214012 GO:0141110 transporter inhibitor activity 4/1626 45/18639 0.0888888888888889 1.01894218942189 0.560515068036697 0.886862700487772 GO:0004180 carboxypeptidase activity 4/1626 46/18639 0.0869565217391304 0.996791272260549 0.57831250208268 0.897297278560071 GO:0030332 cyclin binding 3/1626 34/18639 0.0882352941176471 1.01144996744085 0.579364364507035 0.897297278560071 GO:0016829 lyase activity 17/1626 200/18639 0.085 0.974363468634686 0.581629033132123 0.897297278560071 GO:0005243 gap junction channel activity 2/1626 22/18639 0.0909090909090909 1.04209996645421 0.583647819407198 0.897297278560071 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1626 22/18639 0.0909090909090909 1.04209996645421 0.583647819407198 0.897297278560071 GO:0140035 ubiquitin-like protein reader activity 2/1626 22/18639 0.0909090909090909 1.04209996645421 0.583647819407198 0.897297278560071 GO:0015103 inorganic anion transmembrane transporter activity 14/1626 165/18639 0.0848484848484849 0.972626635357263 0.583869224900149 0.897297278560071 GO:0140299 molecular sensor activity 6/1626 71/18639 0.0845070422535211 0.968712644872928 0.593768090025178 0.897297278560071 GO:0005254 chloride channel activity 7/1626 83/18639 0.0843373493975904 0.966767438758725 0.594056263860657 0.897297278560071 GO:0070063 RNA polymerase binding 5/1626 59/18639 0.0847457627118644 0.971449121270874 0.594150217566143 0.897297278560071 GO:0005504 fatty acid binding 4/1626 47/18639 0.0851063829787234 0.975582947318835 0.595690699737636 0.897297278560071 GO:0140938 histone H3 methyltransferase activity 4/1626 47/18639 0.0851063829787234 0.975582947318835 0.595690699737636 0.897297278560071 GO:0000182 rDNA binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0001094 TFIID-class transcription factor complex binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0005345 purine nucleobase transmembrane transporter activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0015279 store-operated calcium channel activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0016783 sulfurtransferase activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0030957 Tat protein binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0032052 bile acid binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0042975 peroxisome proliferator activated receptor binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0043121 neurotrophin binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0043295 glutathione binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0050308 sugar-phosphatase activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0050815 phosphoserine residue binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0051880 G-quadruplex DNA binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0070097 delta-catenin binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0070513 death domain binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0098505 G-rich strand telomeric DNA binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0140135 mechanosensitive monoatomic cation channel activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0140940 histone H2A methyltransferase activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:1905394 retromer complex binding 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:1990259 histone H2AQ104 methyltransferase activity 1/1626 10/18639 0.1 1.14630996309963 0.598687497106173 0.897297278560071 GO:0004623 phospholipase A2 activity 3/1626 35/18639 0.0857142857142857 0.982551396942541 0.599451744352369 0.897297278560071 GO:0034061 DNA polymerase activity 3/1626 35/18639 0.0857142857142857 0.982551396942541 0.599451744352369 0.897297278560071 GO:0043015 gamma-tubulin binding 3/1626 35/18639 0.0857142857142857 0.982551396942541 0.599451744352369 0.897297278560071 GO:0003887 DNA-directed DNA polymerase activity 2/1626 23/18639 0.0869565217391304 0.996791272260549 0.608286078650107 0.908241917183452 GO:0005212 structural constituent of eye lens 2/1626 23/18639 0.0869565217391304 0.996791272260549 0.608286078650107 0.908241917183452 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5/1626 60/18639 0.0833333333333333 0.955258302583026 0.609355381462316 0.908701212605679 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/1626 48/18639 0.0833333333333333 0.955258302583026 0.612634297995461 0.911312615347363 GO:0140693 molecular condensate scaffold activity 4/1626 48/18639 0.0833333333333333 0.955258302583026 0.612634297995461 0.911312615347363 GO:0004033 aldo-keto reductase (NADPH) activity 3/1626 36/18639 0.0833333333333333 0.955258302583026 0.618897925526142 0.911969154501412 GO:0016409 palmitoyltransferase activity 3/1626 36/18639 0.0833333333333333 0.955258302583026 0.618897925526142 0.911969154501412 GO:0004521 RNA endonuclease activity 6/1626 73/18639 0.0821917808219178 0.942172572410656 0.621316229008358 0.911969154501412 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 19/1626 229/18639 0.0829694323144105 0.951086868947292 0.6253930750029 0.911969154501412 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 10/1626 122/18639 0.0819672131147541 0.939598330409533 0.628832820724498 0.911969154501412 GO:0060590 ATPase regulator activity 4/1626 49/18639 0.0816326530612245 0.935763235183372 0.629130648205751 0.911969154501412 GO:0042626 ATPase-coupled transmembrane transporter activity 8/1626 98/18639 0.0816326530612245 0.935763235183372 0.630388255670765 0.911969154501412 GO:0060229 lipase activator activity 2/1626 24/18639 0.0833333333333333 0.955258302583026 0.63179719793234 0.911969154501412 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1626 24/18639 0.0833333333333333 0.955258302583026 0.63179719793234 0.911969154501412 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0004016 adenylate cyclase activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0008172 S-methyltransferase activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0008503 benzodiazepine receptor activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0015205 nucleobase transmembrane transporter activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0015217 ADP transmembrane transporter activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0019203 carbohydrate phosphatase activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0042608 T cell receptor binding 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0180030 inositol phosphate kinase activity 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:1900750 oligopeptide binding 1/1626 11/18639 0.0909090909090909 1.04209996645421 0.633715363857226 0.911969154501412 GO:0030280 structural constituent of skin epidermis 3/1626 37/18639 0.0810810810810811 0.929440510621322 0.637691639424128 0.916585693774681 GO:0015297 antiporter activity 11/1626 135/18639 0.0814814814814815 0.934030340303403 0.638534152248809 0.916692230605089 GO:1901682 sulfur compound transmembrane transporter activity 5/1626 63/18639 0.0793650793650794 0.909769811983834 0.652921823521823 0.919172809055772 GO:0000030 mannosyltransferase activity 2/1626 25/18639 0.08 0.917047970479705 0.654190214936827 0.919172809055772 GO:0003707 nuclear steroid receptor activity 2/1626 25/18639 0.08 0.917047970479705 0.654190214936827 0.919172809055772 GO:0015271 outward rectifier potassium channel activity 2/1626 25/18639 0.08 0.917047970479705 0.654190214936827 0.919172809055772 GO:0017025 TBP-class protein binding 2/1626 25/18639 0.08 0.917047970479705 0.654190214936827 0.919172809055772 GO:0017056 structural constituent of nuclear pore 2/1626 25/18639 0.08 0.917047970479705 0.654190214936827 0.919172809055772 GO:0004518 nuclease activity 17/1626 209/18639 0.0813397129186603 0.93240523314324 0.655155713100015 0.919172809055772 GO:0005109 frizzled binding 3/1626 38/18639 0.0789473684210526 0.904981549815498 0.655825854372036 0.919172809055772 GO:0003743 translation initiation factor activity 4/1626 51/18639 0.0784313725490196 0.899066637725201 0.660743593981451 0.919172809055772 GO:0016830 carbon-carbon lyase activity 4/1626 51/18639 0.0784313725490196 0.899066637725201 0.660743593981451 0.919172809055772 GO:0005125 cytokine activity 19/1626 234/18639 0.0811965811965812 0.930764499952692 0.662911768543796 0.919172809055772 GO:0003720 telomerase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0003995 acyl-CoA dehydrogenase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0004126 cytidine deaminase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0005049 nuclear export signal receptor activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0005095 GTPase inhibitor activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0005165 neurotrophin receptor binding 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0005247 voltage-gated chloride channel activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0005436 sodium:phosphate symporter activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0008504 monoamine transmembrane transporter activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0015166 polyol transmembrane transporter activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0016273 arginine N-methyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0016274 protein-arginine N-methyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0016423 tRNA (guanine) methyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0035197 siRNA binding 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0036009 protein-glutamine N-methyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0043047 single-stranded telomeric DNA binding 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1626 12/18639 0.0833333333333333 0.955258302583026 0.665687600187919 0.919172809055772 GO:0004536 DNA nuclease activity 5/1626 64/18639 0.078125 0.895554658671587 0.666733847338864 0.919553155925161 GO:0008234 cysteine-type peptidase activity 15/1626 187/18639 0.0802139037433155 0.919499970400774 0.671557380522741 0.922523393757453 GO:0046873 metal ion transmembrane transporter activity 37/1626 450/18639 0.0822222222222222 0.942521525215252 0.673117512885558 0.922523393757453 GO:0005112 Notch binding 2/1626 26/18639 0.0769230769230769 0.881776894692024 0.675481165235562 0.922523393757453 GO:0008143 poly(A) binding 2/1626 26/18639 0.0769230769230769 0.881776894692024 0.675481165235562 0.922523393757453 GO:0030247 polysaccharide binding 2/1626 26/18639 0.0769230769230769 0.881776894692024 0.675481165235562 0.922523393757453 GO:0030507 spectrin binding 2/1626 26/18639 0.0769230769230769 0.881776894692024 0.675481165235562 0.922523393757453 GO:0050681 nuclear androgen receptor binding 2/1626 26/18639 0.0769230769230769 0.881776894692024 0.675481165235562 0.922523393757453 GO:0051139 metal cation:proton antiporter activity 2/1626 26/18639 0.0769230769230769 0.881776894692024 0.675481165235562 0.922523393757453 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/1626 52/18639 0.0769230769230769 0.881776894692024 0.675846979165141 0.922523393757453 GO:0120013 lipid transfer activity 5/1626 65/18639 0.0769230769230769 0.881776894692024 0.680180970995052 0.924231971288973 GO:0015081 sodium ion transmembrane transporter activity 13/1626 164/18639 0.0792682926829268 0.908660336603366 0.681973006365888 0.924231971288973 GO:0005253 monoatomic anion channel activity 8/1626 103/18639 0.0776699029126214 0.890337835417189 0.685725492226074 0.924231971288973 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/1626 40/18639 0.075 0.859732472324723 0.690106315541718 0.924231971288973 GO:0032451 demethylase activity 3/1626 40/18639 0.075 0.859732472324723 0.690106315541718 0.924231971288973 GO:0004864 protein phosphatase inhibitor activity 4/1626 53/18639 0.0754716981132075 0.865139594792174 0.690476366109218 0.924231971288973 GO:0051018 protein kinase A binding 4/1626 53/18639 0.0754716981132075 0.865139594792174 0.690476366109218 0.924231971288973 GO:0003964 RNA-directed DNA polymerase activity 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0005035 death receptor activity 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0008417 fucosyltransferase activity 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0009982 pseudouridine synthase activity 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0017154 semaphorin receptor activity 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0046974 histone H3K9 methyltransferase activity 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0051011 microtubule minus-end binding 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0061459 L-arginine transmembrane transporter activity 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0071837 HMG box domain binding 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0089720 caspase binding 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0097157 pre-mRNA intronic binding 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:1901338 catecholamine binding 1/1626 13/18639 0.0769230769230769 0.881776894692024 0.694870612057487 0.924231971288973 GO:0001671 ATPase activator activity 2/1626 27/18639 0.0740740740740741 0.849118491184912 0.695691793979462 0.924231971288973 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1626 27/18639 0.0740740740740741 0.849118491184912 0.695691793979462 0.924231971288973 GO:0042054 histone methyltransferase activity 5/1626 67/18639 0.0746268656716418 0.855455196343008 0.705966416353347 0.931556879896619 GO:0001530 lipopolysaccharide binding 3/1626 41/18639 0.0731707317073171 0.838763387633876 0.706255966700418 0.931556879896619 GO:0017080 sodium channel regulator activity 3/1626 41/18639 0.0731707317073171 0.838763387633876 0.706255966700418 0.931556879896619 GO:0140318 protein transporter activity 3/1626 41/18639 0.0731707317073171 0.838763387633876 0.706255966700418 0.931556879896619 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/1626 130/18639 0.0769230769230769 0.881776894692024 0.707028296373233 0.931556879896619 GO:0000049 tRNA binding 6/1626 80/18639 0.075 0.859732472324723 0.708760238892244 0.931556879896619 GO:0050698 proteoglycan sulfotransferase activity 2/1626 28/18639 0.0714285714285714 0.818792830785451 0.714848438885431 0.931556879896619 GO:0051537 2 iron, 2 sulfur cluster binding 2/1626 28/18639 0.0714285714285714 0.818792830785451 0.714848438885431 0.931556879896619 GO:0051959 dynein light intermediate chain binding 2/1626 28/18639 0.0714285714285714 0.818792830785451 0.714848438885431 0.931556879896619 GO:0141052 histone H3 demethylase activity 2/1626 28/18639 0.0714285714285714 0.818792830785451 0.714848438885431 0.931556879896619 GO:0005344 oxygen carrier activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0008195 phosphatidate phosphatase activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0015386 potassium:proton antiporter activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0015926 glucosidase activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0031404 chloride ion binding 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0034236 protein kinase A catalytic subunit binding 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0042813 Wnt receptor activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0043176 amine binding 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0046030 inositol trisphosphate phosphatase activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0061665 SUMO ligase activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0070742 C2H2 zinc finger domain binding 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0071933 Arp2/3 complex binding 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:1901474 azole transmembrane transporter activity 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:1901612 cardiolipin binding 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:1990825 sequence-specific mRNA binding 1/1626 14/18639 0.0714285714285714 0.818792830785451 0.721507591805931 0.931556879896619 GO:0016279 protein-lysine N-methyltransferase activity 5/1626 69/18639 0.072463768115942 0.830659393550457 0.730262089561788 0.941840727402392 GO:0019212 phosphatase inhibitor activity 4/1626 56/18639 0.0714285714285714 0.818792830785451 0.731513595508424 0.942435982118304 GO:0004181 metallocarboxypeptidase activity 2/1626 29/18639 0.0689655172413793 0.790558595241125 0.732981064466271 0.94330788555368 GO:0003697 single-stranded DNA binding 9/1626 121/18639 0.0743801652892562 0.852627245280717 0.738620852530604 0.946557344615683 GO:0016278 lysine N-methyltransferase activity 5/1626 70/18639 0.0714285714285714 0.818792830785451 0.741851126188607 0.946557344615683 GO:0004601 peroxidase activity 4/1626 57/18639 0.0701754385964912 0.804428044280443 0.744248127719766 0.946557344615683 GO:0004089 carbonate dehydratase activity 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0005041 low-density lipoprotein particle receptor activity 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0008242 omega peptidase activity 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0015250 water channel activity 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0016846 carbon-sulfur lyase activity 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0034483 heparan sulfate sulfotransferase activity 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0045504 dynein heavy chain binding 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0050700 CARD domain binding 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0050780 dopamine receptor binding 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0061578 K63-linked deubiquitinase activity 1/1626 15/18639 0.0666666666666667 0.764206642066421 0.745820539764243 0.946557344615683 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1626 30/18639 0.0666666666666667 0.764206642066421 0.750122429641232 0.947859725169966 GO:0032452 histone demethylase activity 2/1626 30/18639 0.0666666666666667 0.764206642066421 0.750122429641232 0.947859725169966 GO:0033612 receptor serine/threonine kinase binding 2/1626 30/18639 0.0666666666666667 0.764206642066421 0.750122429641232 0.947859725169966 GO:0048019 receptor antagonist activity 2/1626 30/18639 0.0666666666666667 0.764206642066421 0.750122429641232 0.947859725169966 GO:0030547 signaling receptor inhibitor activity 3/1626 44/18639 0.0681818181818182 0.781574974840657 0.750819312896578 0.947859725169966 GO:0072349 modified amino acid transmembrane transporter activity 2/1626 31/18639 0.0645161290322581 0.739554814902988 0.766307372827604 0.955799848352899 GO:0140457 protein demethylase activity 2/1626 31/18639 0.0645161290322581 0.739554814902988 0.766307372827604 0.955799848352899 GO:0000062 fatty-acyl-CoA binding 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0008296 3'-5'-DNA exonuclease activity 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0015385 sodium:proton antiporter activity 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0017070 U6 snRNA binding 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0019841 retinol binding 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0034450 ubiquitin-ubiquitin ligase activity 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0097027 ubiquitin-protein transferase activator activity 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1626 16/18639 0.0625 0.716443726937269 0.768012109907249 0.955799848352899 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 4/1626 59/18639 0.0677966101694915 0.777159297016699 0.768325276253504 0.955799848352899 GO:0016209 antioxidant activity 6/1626 86/18639 0.0697674418604651 0.799751137046254 0.771884107929263 0.959226813291261 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/1626 46/18639 0.0652173913043478 0.747593454195411 0.777396192161925 0.963404644664403 GO:0043130 ubiquitin binding 7/1626 100/18639 0.07 0.802416974169742 0.779936454610539 0.963404644664403 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1626 32/18639 0.0625 0.716443726937269 0.781572200370235 0.963404644664403 GO:0047498 calcium-dependent phospholipase A2 activity 2/1626 32/18639 0.0625 0.716443726937269 0.781572200370235 0.963404644664403 GO:0140142 nucleocytoplasmic carrier activity 2/1626 32/18639 0.0625 0.716443726937269 0.781572200370235 0.963404644664403 GO:0004519 endonuclease activity 9/1626 127/18639 0.0708661417322835 0.812345643141471 0.788036081658802 0.963404644664403 GO:0004659 prenyltransferase activity 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:0008484 sulfuric ester hydrolase activity 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:0008569 minus-end-directed microtubule motor activity 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:0009881 photoreceptor activity 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:0019198 transmembrane receptor protein phosphatase activity 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:1901567 fatty acid derivative binding 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:1990226 histone methyltransferase binding 1/1626 17/18639 0.0588235294117647 0.674299978293901 0.788267294855475 0.963404644664403 GO:0061749 forked DNA-dependent helicase activity 3/1626 47/18639 0.0638297872340425 0.731687210489126 0.789785203009035 0.963404644664403 GO:1990518 single-stranded 3'-5' DNA helicase activity 3/1626 47/18639 0.0638297872340425 0.731687210489126 0.789785203009035 0.963404644664403 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/1626 61/18639 0.0655737704918033 0.751678664327627 0.790589394070788 0.963404644664403 GO:0019905 syntaxin binding 4/1626 61/18639 0.0655737704918033 0.751678664327627 0.790589394070788 0.963404644664403 GO:0044183 protein folding chaperone 5/1626 75/18639 0.0666666666666667 0.764206642066421 0.794299120600755 0.966937602935409 GO:0009378 four-way junction helicase activity 3/1626 48/18639 0.0625 0.716443726937269 0.801595263343274 0.969243375924071 GO:0036121 double-stranded DNA helicase activity 3/1626 48/18639 0.0625 0.716443726937269 0.801595263343274 0.969243375924071 GO:0043138 3'-5' DNA helicase activity 3/1626 48/18639 0.0625 0.716443726937269 0.801595263343274 0.969243375924071 GO:0016247 channel regulator activity 12/1626 168/18639 0.0714285714285714 0.818792830785451 0.804602483907451 0.969243375924071 GO:0000400 four-way junction DNA binding 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:0004970 glutamate-gated receptor activity 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:0005372 water transmembrane transporter activity 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:0008308 voltage-gated monoatomic anion channel activity 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:0017128 phospholipid scramblase activity 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:0032393 MHC class I receptor activity 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:0035615 clathrin adaptor activity 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:0099602 neurotransmitter receptor regulator activity 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:1901611 phosphatidylglycerol binding 1/1626 18/18639 0.0555555555555556 0.636838868388684 0.806754964201678 0.969243375924071 GO:0016831 carboxy-lyase activity 2/1626 34/18639 0.0588235294117647 0.674299978293901 0.809491028313958 0.969265021064811 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1626 34/18639 0.0588235294117647 0.674299978293901 0.809491028313958 0.969265021064811 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1626 34/18639 0.0588235294117647 0.674299978293901 0.809491028313958 0.969265021064811 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/1626 130/18639 0.0692307692307692 0.793599205222821 0.810022821459863 0.969265021064811 GO:0003724 RNA helicase activity 5/1626 77/18639 0.0649350649350649 0.744357118895864 0.812790502186469 0.971602273655769 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 6/1626 91/18639 0.0659340659340659 0.755808766878878 0.81619025926121 0.972861106757077 GO:0031072 heat shock protein binding 9/1626 131/18639 0.0687022900763359 0.787541196022647 0.816956998656721 0.972861106757077 GO:0141108 transporter regulator activity 12/1626 170/18639 0.0705882352941176 0.809159973952681 0.816990150440856 0.972861106757077 GO:0001664 G protein-coupled receptor binding 22/1626 297/18639 0.0740740740740741 0.849118491184912 0.818611979247124 0.972861106757077 GO:0016229 steroid dehydrogenase activity 2/1626 35/18639 0.0571428571428571 0.65503426462836 0.822220681887388 0.972861106757077 GO:0140566 histone reader activity 2/1626 35/18639 0.0571428571428571 0.65503426462836 0.822220681887388 0.972861106757077 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/1626 19/18639 0.0526315789473684 0.603321033210332 0.823629268922588 0.972861106757077 GO:0008301 DNA binding, bending 1/1626 19/18639 0.0526315789473684 0.603321033210332 0.823629268922588 0.972861106757077 GO:0016918 retinal binding 1/1626 19/18639 0.0526315789473684 0.603321033210332 0.823629268922588 0.972861106757077 GO:0022821 solute:potassium antiporter activity 1/1626 19/18639 0.0526315789473684 0.603321033210332 0.823629268922588 0.972861106757077 GO:0120227 acyl-CoA binding 1/1626 19/18639 0.0526315789473684 0.603321033210332 0.823629268922588 0.972861106757077 GO:1990380 K48-linked deubiquitinase activity 1/1626 19/18639 0.0526315789473684 0.603321033210332 0.823629268922588 0.972861106757077 GO:0008186 ATP-dependent activity, acting on RNA 5/1626 79/18639 0.0632911392405063 0.725512634873184 0.829927852794729 0.979331284257281 GO:0005048 signal sequence binding 3/1626 51/18639 0.0588235294117647 0.674299978293901 0.833720626510368 0.980055298469276 GO:0000993 RNA polymerase II complex binding 2/1626 36/18639 0.0555555555555556 0.636838868388684 0.834180844026285 0.980055298469276 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1626 36/18639 0.0555555555555556 0.636838868388684 0.834180844026285 0.980055298469276 GO:0045505 dynein intermediate chain binding 2/1626 36/18639 0.0555555555555556 0.636838868388684 0.834180844026285 0.980055298469276 GO:0099106 ion channel regulator activity 11/1626 160/18639 0.06875 0.788088099630996 0.834648938176685 0.980055298469276 GO:0016408 C-acyltransferase activity 1/1626 20/18639 0.05 0.573154981549815 0.839030923526878 0.982300188191919 GO:0030742 GTP-dependent protein binding 1/1626 20/18639 0.05 0.573154981549815 0.839030923526878 0.982300188191919 GO:0061608 nuclear import signal receptor activity 1/1626 20/18639 0.05 0.573154981549815 0.839030923526878 0.982300188191919 GO:0004843 cysteine-type deubiquitinase activity 7/1626 108/18639 0.0648148148148148 0.742978679786798 0.84186959130603 0.984657276890288 GO:0030159 signaling receptor complex adaptor activity 3/1626 52/18639 0.0576923076923077 0.661332671019018 0.843386360021301 0.985465159162989 GO:0022829 wide pore channel activity 2/1626 37/18639 0.0540540540540541 0.619627007080882 0.845408798574979 0.986861738453963 GO:0008276 protein methyltransferase activity 6/1626 95/18639 0.0631578947368421 0.723985239852399 0.846510212582778 0.987181508906406 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1626 53/18639 0.0566037735849057 0.648854696094131 0.852560959656026 0.989051927363155 GO:0140296 general transcription initiation factor binding 3/1626 53/18639 0.0566037735849057 0.648854696094131 0.852560959656026 0.989051927363155 GO:0009975 cyclase activity 1/1626 21/18639 0.0476190476190476 0.5458618871903 0.853088376577273 0.989051927363155 GO:0035613 RNA stem-loop binding 1/1626 21/18639 0.0476190476190476 0.5458618871903 0.853088376577273 0.989051927363155 GO:0070182 DNA polymerase binding 1/1626 21/18639 0.0476190476190476 0.5458618871903 0.853088376577273 0.989051927363155 GO:1904047 S-adenosyl-L-methionine binding 1/1626 21/18639 0.0476190476190476 0.5458618871903 0.853088376577273 0.989051927363155 GO:0140223 general transcription initiation factor activity 4/1626 68/18639 0.0588235294117647 0.674299978293901 0.855251337586257 0.990596937612043 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/1626 54/18639 0.0555555555555556 0.636838868388684 0.861262768608794 0.996592127012891 GO:0008093 cytoskeletal anchor activity 1/1626 22/18639 0.0454545454545455 0.521049983227105 0.865918879299657 0.99681870831979 GO:0008649 rRNA methyltransferase activity 1/1626 22/18639 0.0454545454545455 0.521049983227105 0.865918879299657 0.99681870831979 GO:0016881 acid-amino acid ligase activity 1/1626 22/18639 0.0454545454545455 0.521049983227105 0.865918879299657 0.99681870831979 GO:0061133 endopeptidase activator activity 1/1626 22/18639 0.0454545454545455 0.521049983227105 0.865918879299657 0.99681870831979 GO:0070034 telomerase RNA binding 1/1626 22/18639 0.0454545454545455 0.521049983227105 0.865918879299657 0.99681870831979 GO:0008170 N-methyltransferase activity 6/1626 98/18639 0.0612244897959184 0.701822426387529 0.86647191997286 0.99681870831979 GO:0016782 transferase activity, transferring sulphur-containing groups 4/1626 70/18639 0.0571428571428571 0.65503426462836 0.87028188406883 0.999999996637044 GO:0016874 ligase activity 11/1626 167/18639 0.0658682634730539 0.755054466712332 0.871602901978456 0.999999996637044 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/1626 23/18639 0.0434782608695652 0.498395636130274 0.877629461147364 0.999999996637044 GO:0008171 O-methyltransferase activity 1/1626 23/18639 0.0434782608695652 0.498395636130274 0.877629461147364 0.999999996637044 GO:0031681 G-protein beta-subunit binding 1/1626 23/18639 0.0434782608695652 0.498395636130274 0.877629461147364 0.999999996637044 GO:0070577 lysine-acetylated histone binding 1/1626 23/18639 0.0434782608695652 0.498395636130274 0.877629461147364 0.999999996637044 GO:0140102 catalytic activity, acting on a rRNA 1/1626 23/18639 0.0434782608695652 0.498395636130274 0.877629461147364 0.999999996637044 GO:0004386 helicase activity 10/1626 155/18639 0.0645161290322581 0.739554814902988 0.878303253622788 0.999999996637044 GO:0140828 metal cation:monoatomic cation antiporter activity 2/1626 41/18639 0.0487804878048781 0.559175591755918 0.883718286158181 0.999999996637044 GO:0101005 deubiquitinase activity 7/1626 115/18639 0.0608695652173913 0.697753890582384 0.88385076091895 0.999999996637044 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/1626 24/18639 0.0416666666666667 0.477629151291513 0.888317820417582 0.999999996637044 GO:0004806 triacylglycerol lipase activity 1/1626 24/18639 0.0416666666666667 0.477629151291513 0.888317820417582 0.999999996637044 GO:0070300 phosphatidic acid binding 1/1626 24/18639 0.0416666666666667 0.477629151291513 0.888317820417582 0.999999996637044 GO:0070840 dynein complex binding 1/1626 24/18639 0.0416666666666667 0.477629151291513 0.888317820417582 0.999999996637044 GO:0140033 acetylation-dependent protein binding 1/1626 24/18639 0.0416666666666667 0.477629151291513 0.888317820417582 0.999999996637044 GO:0017116 single-stranded DNA helicase activity 3/1626 58/18639 0.0517241379310345 0.592918946430844 0.891706779233767 0.999999996637044 GO:0031492 nucleosomal DNA binding 2/1626 42/18639 0.0476190476190476 0.5458618871903 0.89181659084276 0.999999996637044 GO:0048487 beta-tubulin binding 2/1626 42/18639 0.0476190476190476 0.5458618871903 0.89181659084276 0.999999996637044 GO:0051879 Hsp90 protein binding 2/1626 42/18639 0.0476190476190476 0.5458618871903 0.89181659084276 0.999999996637044 GO:0001848 complement binding 1/1626 25/18639 0.04 0.458523985239852 0.898073137312614 0.999999996637044 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/1626 25/18639 0.04 0.458523985239852 0.898073137312614 0.999999996637044 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/1626 25/18639 0.04 0.458523985239852 0.898073137312614 0.999999996637044 GO:0019707 protein-cysteine S-acyltransferase activity 1/1626 25/18639 0.04 0.458523985239852 0.898073137312614 0.999999996637044 GO:0015459 potassium channel regulator activity 3/1626 59/18639 0.0508474576271186 0.582869472762524 0.89831650260771 0.999999996637044 GO:0031593 polyubiquitin modification-dependent protein binding 3/1626 59/18639 0.0508474576271186 0.582869472762524 0.89831650260771 0.999999996637044 GO:0001098 basal transcription machinery binding 3/1626 60/18639 0.05 0.573154981549815 0.904560514916611 0.999999996637044 GO:0001099 basal RNA polymerase II transcription machinery binding 3/1626 60/18639 0.05 0.573154981549815 0.904560514916611 0.999999996637044 GO:0016790 thiolester hydrolase activity 2/1626 44/18639 0.0454545454545455 0.521049983227105 0.906462672905793 0.999999996637044 GO:0004529 DNA exonuclease activity 1/1626 26/18639 0.0384615384615385 0.440888447346012 0.906976816195696 0.999999996637044 GO:0005227 calcium-activated cation channel activity 1/1626 26/18639 0.0384615384615385 0.440888447346012 0.906976816195696 0.999999996637044 GO:0008066 glutamate receptor activity 1/1626 26/18639 0.0384615384615385 0.440888447346012 0.906976816195696 0.999999996637044 GO:0019865 immunoglobulin binding 1/1626 26/18639 0.0384615384615385 0.440888447346012 0.906976816195696 0.999999996637044 GO:0034237 protein kinase A regulatory subunit binding 1/1626 26/18639 0.0384615384615385 0.440888447346012 0.906976816195696 0.999999996637044 GO:0097602 cullin family protein binding 1/1626 26/18639 0.0384615384615385 0.440888447346012 0.906976816195696 0.999999996637044 GO:0120014 phospholipid transfer activity 1/1626 26/18639 0.0384615384615385 0.440888447346012 0.906976816195696 0.999999996637044 GO:0051087 protein-folding chaperone binding 8/1626 134/18639 0.0597014925373134 0.684364157074407 0.907181167983645 0.999999996637044 GO:0032182 ubiquitin-like protein binding 7/1626 120/18639 0.0583333333333333 0.668680811808118 0.907766286218444 0.999999996637044 GO:0004497 monooxygenase activity 6/1626 106/18639 0.0566037735849057 0.648854696094131 0.90937441438162 0.999999996637044 GO:0016836 hydro-lyase activity 3/1626 61/18639 0.0491803278688525 0.56375899824572 0.910455572891395 0.999999996637044 GO:0004364 glutathione transferase activity 1/1626 27/18639 0.037037037037037 0.424559245592456 0.915103163204013 0.999999996637044 GO:0035255 ionotropic glutamate receptor binding 1/1626 27/18639 0.037037037037037 0.424559245592456 0.915103163204013 0.999999996637044 GO:0099094 ligand-gated monoatomic cation channel activity 8/1626 136/18639 0.0588235294117647 0.674299978293901 0.915143154405942 0.999999996637044 GO:0016835 carbon-oxygen lyase activity 4/1626 79/18639 0.0506329113924051 0.580410107898547 0.922359867345905 0.999999996637044 GO:0036408 histone H3K14 acetyltransferase activity 1/1626 28/18639 0.0357142857142857 0.409396415392725 0.922520004845441 0.999999996637044 GO:0046966 nuclear thyroid hormone receptor binding 1/1626 28/18639 0.0357142857142857 0.409396415392725 0.922520004845441 0.999999996637044 GO:0099095 ligand-gated monoatomic anion channel activity 2/1626 47/18639 0.0425531914893617 0.487791473659417 0.924990031663073 0.999999996637044 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/1626 29/18639 0.0344827586206897 0.395279297620562 0.929289252716126 0.999999996637044 GO:0010484 histone H3 acetyltransferase activity 1/1626 29/18639 0.0344827586206897 0.395279297620562 0.929289252716126 0.999999996637044 GO:0016417 S-acyltransferase activity 1/1626 29/18639 0.0344827586206897 0.395279297620562 0.929289252716126 0.999999996637044 GO:0097472 cyclin-dependent protein kinase activity 1/1626 29/18639 0.0344827586206897 0.395279297620562 0.929289252716126 0.999999996637044 GO:0106222 lncRNA binding 1/1626 29/18639 0.0344827586206897 0.395279297620562 0.929289252716126 0.999999996637044 GO:0008188 neuropeptide receptor activity 2/1626 48/18639 0.0416666666666667 0.477629151291513 0.930355021590021 0.999999996637044 GO:0038187 pattern recognition receptor activity 2/1626 48/18639 0.0416666666666667 0.477629151291513 0.930355021590021 0.999999996637044 GO:0019783 ubiquitin-like protein peptidase activity 7/1626 127/18639 0.0551181102362205 0.631824389110033 0.934082117399882 0.999999996637044 GO:0022839 monoatomic ion-gated channel activity 1/1626 30/18639 0.0333333333333333 0.38210332103321 0.935467419029054 0.999999996637044 GO:0043995 histone H4K5 acetyltransferase activity 1/1626 30/18639 0.0333333333333333 0.38210332103321 0.935467419029054 0.999999996637044 GO:0043996 histone H4K8 acetyltransferase activity 1/1626 30/18639 0.0333333333333333 0.38210332103321 0.935467419029054 0.999999996637044 GO:0043997 histone H4K12 acetyltransferase activity 1/1626 30/18639 0.0333333333333333 0.38210332103321 0.935467419029054 0.999999996637044 GO:0048020 CCR chemokine receptor binding 2/1626 50/18639 0.04 0.458523985239852 0.940014286205134 0.999999996637044 GO:0140658 ATP-dependent chromatin remodeler activity 9/1626 158/18639 0.0569620253164557 0.652961371385866 0.940280734905082 0.999999996637044 GO:0030544 Hsp70 protein binding 2/1626 51/18639 0.0392156862745098 0.4495333188626 0.944352802927369 0.999999996637044 GO:0022834 ligand-gated channel activity 11/1626 188/18639 0.0585106382978723 0.670713276281699 0.944365859586736 0.999999996637044 GO:0140597 protein carrier chaperone 11/1626 188/18639 0.0585106382978723 0.670713276281699 0.944365859586736 0.999999996637044 GO:0016887 ATP hydrolysis activity 28/1626 417/18639 0.0671462829736211 0.76970453157769 0.944811684460248 0.999999996637044 GO:0009055 electron transfer activity 6/1626 116/18639 0.0517241379310345 0.592918946430844 0.945806701836406 0.999999996637044 GO:0005262 calcium channel activity 7/1626 131/18639 0.0534351145038168 0.612532041350948 0.945944729556913 0.999999996637044 GO:0042910 xenobiotic transmembrane transporter activity 1/1626 32/18639 0.03125 0.358221863468635 0.946252341650786 0.999999996637044 GO:0098960 postsynaptic neurotransmitter receptor activity 3/1626 69/18639 0.0434782608695652 0.498395636130274 0.94691302758775 0.999999996637044 GO:0015085 calcium ion transmembrane transporter activity 8/1626 147/18639 0.054421768707483 0.623842156788915 0.949221119174074 0.999999996637044 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/1626 33/18639 0.0303030303030303 0.347366655484737 0.950949159648089 0.999999996637044 GO:0008146 sulfotransferase activity 2/1626 53/18639 0.0377358490566038 0.432569797396087 0.95214951950587 0.999999996637044 GO:0034212 protein N-acetyltransferase activity 2/1626 53/18639 0.0377358490566038 0.432569797396087 0.95214951950587 0.999999996637044 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/1626 53/18639 0.0377358490566038 0.432569797396087 0.95214951950587 0.999999996637044 GO:0140713 histone chaperone activity 9/1626 164/18639 0.0548780487804878 0.629072540725407 0.954690805019857 0.999999996637044 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4/1626 88/18639 0.0454545454545455 0.521049983227105 0.954835956328496 0.999999996637044 GO:0008175 tRNA methyltransferase activity 1/1626 34/18639 0.0294117647058824 0.33714998914695 0.955235769688517 0.999999996637044 GO:0015020 glucuronosyltransferase activity 1/1626 34/18639 0.0294117647058824 0.33714998914695 0.955235769688517 0.999999996637044 GO:0050661 NADP binding 2/1626 54/18639 0.037037037037037 0.424559245592456 0.955645163771142 0.999999996637044 GO:0140463 chromatin-protein adaptor activity 2/1626 54/18639 0.037037037037037 0.424559245592456 0.955645163771142 0.999999996637044 GO:0042379 chemokine receptor binding 3/1626 72/18639 0.0416666666666667 0.477629151291513 0.956594662871451 0.999999996637044 GO:0000510 H3-H4 histone complex chaperone activity 8/1626 151/18639 0.0529801324503311 0.607316536741526 0.958205254608013 0.999999996637044 GO:0140584 chromatin extrusion motor activity 8/1626 151/18639 0.0529801324503311 0.607316536741526 0.958205254608013 0.999999996637044 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 8/1626 151/18639 0.0529801324503311 0.607316536741526 0.958205254608013 0.999999996637044 GO:0140849 ATP-dependent H2AZ histone chaperone activity 8/1626 151/18639 0.0529801324503311 0.607316536741526 0.958205254608013 0.999999996637044 GO:0015399 primary active transmembrane transporter activity 9/1626 166/18639 0.0542168674698795 0.621493353487752 0.958756286049223 0.999999996637044 GO:0010485 histone H4 acetyltransferase activity 1/1626 35/18639 0.0285714285714286 0.32751713231418 0.959147978153256 0.999999996637044 GO:0015616 DNA translocase activity 8/1626 152/18639 0.0526315789473684 0.603321033210332 0.960216027189815 0.999999996637044 GO:0140674 ATP-dependent histone chaperone activity 8/1626 152/18639 0.0526315789473684 0.603321033210332 0.960216027189815 0.999999996637044 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/1626 56/18639 0.0357142857142857 0.409396415392725 0.961916813172379 0.999999996637044 GO:0003678 DNA helicase activity 3/1626 74/18639 0.0405405405405405 0.464720255310661 0.962101882493547 0.999999996637044 GO:0031491 nucleosome binding 3/1626 74/18639 0.0405405405405405 0.464720255310661 0.962101882493547 0.999999996637044 GO:0061775 cohesin loader activity 8/1626 153/18639 0.0522875816993464 0.599377758483467 0.962139390987947 0.999999996637044 GO:0004190 aspartic-type endopeptidase activity 1/1626 36/18639 0.0277777777777778 0.318419434194342 0.962718467699741 0.999999996637044 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1626 36/18639 0.0277777777777778 0.318419434194342 0.962718467699741 0.999999996637044 GO:0070001 aspartic-type peptidase activity 1/1626 37/18639 0.027027027027027 0.309813503540441 0.965977069619874 0.999999996637044 GO:0051536 iron-sulfur cluster binding 3/1626 76/18639 0.0394736842105263 0.452490774907749 0.966946704412482 0.999999996637044 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/1626 58/18639 0.0344827586206897 0.395279297620562 0.967331945496839 0.999999996637044 GO:0015276 ligand-gated monoatomic ion channel activity 10/1626 186/18639 0.0537634408602151 0.616295679085823 0.967928710516472 0.999999996637044 GO:0042162 telomeric DNA binding 1/1626 38/18639 0.0263157894736842 0.301660516605166 0.968951012464626 0.999999996637044 GO:0016410 N-acyltransferase activity 4/1626 94/18639 0.0425531914893617 0.487791473659417 0.968951544306664 0.999999996637044 GO:0051540 metal cluster binding 3/1626 77/18639 0.038961038961039 0.446614271337519 0.96914391842527 0.999999996637044 GO:0036002 pre-mRNA binding 2/1626 59/18639 0.0338983050847458 0.388579648508349 0.969753539984177 0.999999996637044 GO:0000217 DNA secondary structure binding 1/1626 39/18639 0.0256410256410256 0.293925631564008 0.971665149002044 0.999999996637044 GO:0003823 antigen binding 9/1626 174/18639 0.0517241379310345 0.592918946430844 0.971946422627702 0.999999996637044 GO:0003730 mRNA 3'-UTR binding 15/1626 262/18639 0.0572519083969466 0.656284330018873 0.9731978784063 0.999999996637044 GO:0003689 DNA clamp loader activity 8/1626 160/18639 0.05 0.573154981549815 0.973414946489492 0.999999996637044 GO:0015079 potassium ion transmembrane transporter activity 8/1626 160/18639 0.05 0.573154981549815 0.973414946489492 0.999999996637044 GO:0140662 ATP-dependent protein folding chaperone 1/1626 40/18639 0.025 0.286577490774908 0.974142163395737 0.999999996637044 GO:0030594 neurotransmitter receptor activity 4/1626 97/18639 0.0412371134020619 0.472705139422528 0.974350405958469 0.999999996637044 GO:0140104 molecular carrier activity 14/1626 249/18639 0.0562248995983936 0.64451162583915 0.974525308361999 0.999999996637044 GO:0005249 voltage-gated potassium channel activity 4/1626 98/18639 0.0408163265306122 0.467881617591686 0.97594495731236 0.999999996637044 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/1626 41/18639 0.024390243902439 0.279587795877959 0.976402760326675 0.999999996637044 GO:0008227 G protein-coupled amine receptor activity 1/1626 41/18639 0.024390243902439 0.279587795877959 0.976402760326675 0.999999996637044 GO:0022824 transmitter-gated monoatomic ion channel activity 2/1626 63/18639 0.0317460317460317 0.363907924793534 0.977818948189361 0.999999996637044 GO:0022835 transmitter-gated channel activity 2/1626 63/18639 0.0317460317460317 0.363907924793534 0.977818948189361 0.999999996637044 GO:0004402 histone acetyltransferase activity 1/1626 42/18639 0.0238095238095238 0.27293094359515 0.978465837631161 0.999999996637044 GO:0005245 voltage-gated calcium channel activity 1/1626 43/18639 0.0232558139534884 0.266583712348751 0.980348643890866 0.999999996637044 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 8/1626 167/18639 0.0479041916167665 0.549130521245332 0.981539174148294 0.999999996637044 GO:0003954 NADH dehydrogenase activity 1/1626 44/18639 0.0227272727272727 0.260524991613553 0.982066922285868 0.999999996637044 GO:0043014 alpha-tubulin binding 1/1626 44/18639 0.0227272727272727 0.260524991613553 0.982066922285868 0.999999996637044 GO:0016741 transferase activity, transferring one-carbon groups 11/1626 215/18639 0.0511627906976744 0.586484167167253 0.983627668487653 0.999999996637044 GO:0008009 chemokine activity 1/1626 45/18639 0.0222222222222222 0.254735547355474 0.983635041907442 0.999999996637044 GO:0051539 4 iron, 4 sulfur cluster binding 1/1626 45/18639 0.0222222222222222 0.254735547355474 0.983635041907442 0.999999996637044 GO:0051082 unfolded protein binding 5/1626 121/18639 0.0413223140495868 0.473681802933732 0.983654546090697 0.999999996637044 GO:0008173 RNA methyltransferase activity 2/1626 67/18639 0.0298507462686567 0.342182078537203 0.983783219362995 0.999999996637044 GO:0015078 proton transmembrane transporter activity 9/1626 185/18639 0.0486486486486487 0.557664306372794 0.983859522552838 0.999999996637044 GO:0008528 G protein-coupled peptide receptor activity 5/1626 122/18639 0.040983606557377 0.469799165204767 0.98463324933841 0.999999996637044 GO:0042393 histone binding 13/1626 247/18639 0.0526315789473684 0.603321033210332 0.985318968329847 0.999999996637044 GO:0008080 N-acetyltransferase activity 2/1626 69/18639 0.0289855072463768 0.332263757420183 0.986148387170125 0.999999996637044 GO:0061733 protein-lysine-acetyltransferase activity 1/1626 47/18639 0.0212765957446809 0.243895736829709 0.986372119491882 0.999999996637044 GO:0140030 modification-dependent protein binding 8/1626 173/18639 0.046242774566474 0.530085532069194 0.986606677647105 0.999999996637044 GO:0008168 methyltransferase activity 10/1626 204/18639 0.0490196078431373 0.56191664857825 0.98662223400379 0.999999996637044 GO:0140097 catalytic activity, acting on DNA 19/1626 336/18639 0.056547619047619 0.648210991038482 0.98676301282771 0.999999996637044 GO:0020037 heme binding 6/1626 142/18639 0.0422535211267606 0.484356322436464 0.987463780938594 0.999999996637044 GO:0022843 voltage-gated monoatomic cation channel activity 6/1626 143/18639 0.041958041958042 0.480969215286559 0.988187107109623 0.999999996637044 GO:0001653 peptide receptor activity 5/1626 128/18639 0.0390625 0.447777329335793 0.989438659284572 0.999999996637044 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/1626 73/18639 0.0273972602739726 0.314057524136885 0.989913680441492 0.999999996637044 GO:0008094 ATP-dependent activity, acting on DNA 10/1626 210/18639 0.0476190476190476 0.5458618871903 0.990143177630342 0.999999996637044 GO:0005272 sodium channel activity 1/1626 51/18639 0.0196078431372549 0.2247666594313 0.990550076545535 0.999999996637044 GO:0003684 damaged DNA binding 2/1626 74/18639 0.027027027027027 0.309813503540441 0.99068623038449 0.999999996637044 GO:0035064 methylated histone binding 2/1626 74/18639 0.027027027027027 0.309813503540441 0.99068623038449 0.999999996637044 GO:0140034 methylation-dependent protein binding 2/1626 76/18639 0.0263157894736842 0.301660516605166 0.992061780594372 0.999999996637044 GO:0046906 tetrapyrrole binding 6/1626 152/18639 0.0394736842105263 0.452490774907749 0.993142635077429 0.999999996637044 GO:0022853 active monoatomic ion transmembrane transporter activity 4/1626 118/18639 0.0338983050847458 0.388579648508349 0.993642391545507 0.999999996637044 GO:0005244 voltage-gated monoatomic ion channel activity 7/1626 173/18639 0.0404624277456647 0.463824840560544 0.99466508851171 0.999999996637044 GO:0140098 catalytic activity, acting on RNA 21/1626 387/18639 0.0542635658914729 0.622028662147087 0.994735419250877 0.999999996637044 GO:0022832 voltage-gated channel activity 7/1626 175/18639 0.04 0.458523985239852 0.995264436117202 0.999999996637044 GO:0005267 potassium channel activity 4/1626 124/18639 0.032258064516129 0.369777407451494 0.995799357302928 0.999999996637044 GO:0005216 monoatomic ion channel activity 24/1626 448/18639 0.0535714285714286 0.614094623089088 0.997489099549836 0.999999996637044 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/1626 67/18639 0.0149253731343284 0.171091039268602 0.997816919814636 0.999999996637044 GO:0022836 gated channel activity 15/1626 318/18639 0.0471698113207547 0.540712246745109 0.997915068621245 0.999999996637044 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 1/1626 68/18639 0.0147058823529412 0.168574994573475 0.998008051000367 0.999999996637044 GO:0140101 catalytic activity, acting on a tRNA 4/1626 139/18639 0.0287769784172662 0.329873370676153 0.998546470363952 0.999999996637044 GO:0005261 monoatomic cation channel activity 14/1626 341/18639 0.0410557184750733 0.470625791301901 0.999729692318901 0.999999996637044 GO:0045182 translation regulator activity 10/1626 356/18639 0.0280898876404494 0.321997180645964 0.999998658718517 0.999999996637044 GO:0030371 translation repressor activity 5/1626 329/18639 0.0151975683890578 0.174211240592649 0.999999996637044 0.999999996637044