category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	22/120	227/9376	7.57239353891336	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/GSTA3/MT-ND3/MT-ND4/SLC26A2/COX4I1/MT-CO2/MGST3/MT-ATP6/MT-ND2/MT-ND1/NDUFA10/HRAS/GSTO1/NDUFA6/MAP2K2/NDUFB7/GSTA4	11.4133796339036
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	16/120	138/9376	9.05893719806763	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/COX4I1/MT-CO2/MT-ATP6/ATP6V0B/MT-ND2/MT-ND1/NDUFA10/NDUFA6/NDUFB7	10.8590772812183
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	16/120	205/9376	6.09821138211382	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/COX4I1/MT-CO2/PRKCZ/MT-ATP6/MT-ND2/MT-ND1/NDUFA10/NDUFA6/NDUFB7	8.40332209774383
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	17/120	235/9376	5.65219858156028	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/COX4I1/MT-CO2/COX20/MT-ATP6/MT-ND2/MT-ND1/NDUFA10/HRAS/NDUFA6/NDUFB7	8.22356083370304
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	19/120	308/9376	4.81991341991342	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/COX4I1/MT-CO2/POLR2J3/AP2S1/MT-ATP6/MT-ND2/MT-ND1/NDUFA10/NDUFA6/NDUFB7/AP2A1/TFAM	7.76135789584052
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/120	275/9376	5.11418181818182	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/HSPA1A/MT-ND4/COX4I1/MT-CO2/MT-ATP6/MT-ND2/MT-ND1/C1QA/NDUFA10/NDUFA6/C1QC/NDUFB7	7.88442195406373
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	15/120	268/9376	4.37313432835821	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/COX4I1/MT-CO2/MT-ATP6/MT-ND2/MT-ND1/NDUFA10/NDUFA6/NDUFB7	6.37902215850725
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	18/120	388/9376	3.62474226804124	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/COX4I1/MT-CO2/MME/MT-ATP6/MT-ND2/MT-ND1/NDUFA10/HRAS/NDUFA6/MAP2K2/NDUFB7	6.01222997098422
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/120	149/9376	5.76823266219239	MT-ND4L/MT-ND5/MT-ND6/MT-ND3/MT-ND4/MT-ND2/MT-ND1/NDUFA10/GABRE/NDUFA6/NDUFB7	6.68012978819497
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/120	170/9376	4.59607843137255	PLCG2/GSTA3/MGST3/BRD7/GADD45G/CCND1/HRAS/GSTO1/MAP2K2/GSTA4	5.38744337971053
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	15/120	368/9376	3.18478260869565	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/COX4I1/MT-CO2/MT-ATP6/MT-ND2/MT-ND1/NDUFA10/NDUFA6/NDUFB7	4.86835835715064
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/120	59/9376	7.94576271186441	GSTA3/MGST3/SMS/GPX4/GSTO1/GSTA4	6.09357960124417
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	17/120	480/9376	2.76722222222222	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/COX4I1/MT-CO2/MT-ATP6/MT-ND2/MT-ND1/NDUFA10/HRAS/NDUFA6/MAP2K2/NDUFB7	4.52562936624952
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/120	50/9376	7.81333333333333	SAT1/CKMT1A/ARG2/SMS/ALDH7A1	5.49998520959853
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/120	37/9376	8.44684684684685	GADD45G/CCND1/HRAS/MAP2K2	5.16758566407489
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/120	73/9376	5.35159817351598	PLCG2/GADD45G/CCND1/HRAS/MAP2K2	4.24974912975519
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/120	76/9376	5.14035087719298	PLCG2/GADD45G/CCND1/HRAS/MAP2K2	4.12635945416054
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/120	116/9376	4.04137931034483	ACSS1/ECHS1/TKT/GCSH/PGP/SDSL	3.75282814273102
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/120	204/9376	3.0640522875817	PLCG2/CD44/TWIST1/ITGB1/CCND1/HRAS/DCN/MAP2K2	3.39366011105563
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/120	53/9376	5.89685534591195	AP2S1/ATP2B1/ATP1B3/AP2A1	4.07044561003919
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/120	217/9376	2.88049155145929	GSTA3/MGST3/HSP90B1/CCND1/HRAS/GSTO1/MAP2K2/GSTA4	3.19111027442392
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/120	59/9376	5.29717514124294	GADD45G/CCND1/HRAS/MAP2K2	3.76995009330268
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/120	174/9376	3.14329501915709	RRBP1/HSPA1A/TUSC3/HSP90B1/PDIA3/LMAN1/CANX	3.24922699405514
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/120	31/9376	7.56129032258065	ACSS1/GCSH/PGP	4.16624722178217
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/120	60/9376	5.20888888888889	PLCG2/HSPB1/HRAS/MAP2K2	3.72385647812748
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/120	61/9376	5.12349726775956	SLC34A2/MT2A/ATP2B1/ATP1B3	3.67877975041297
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/120	32/9376	7.325	ACSS1/ECHS1/LDHB	4.08069083282265
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/120	142/9376	3.30140845070422	GSTA3/MGST3/HSP90B1/PRKCZ/GSTO1/GSTA4	3.14635360003479
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/120	70/9376	4.4647619047619	GSTA3/MGST3/GSTO1/GSTA4	3.31287828196894
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/120	71/9376	4.4018779342723	CCND2/CCND1/HRAS/MAP2K2	3.27607850411118
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/120	73/9376	4.28127853881278	GSTA3/MGST3/GSTO1/GSTA4	3.20448029868004
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/120	73/9376	4.28127853881278	GADD45G/CCND1/HRAS/MAP2K2	3.20448029868004
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/120	155/9376	3.02451612903226	ITGB1/ATP6V0B/HLA-DPB1/CANX/VAMP3/DYNC1H1	2.89376105440917
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/120	41/9376	5.71707317073171	GCSH/ALDH7A1/SDSL	3.4464498906983
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/120	41/9376	5.71707317073171	CCND1/HRAS/MAP2K2	3.4464498906983
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/120	157/9376	2.9859872611465	BSG/ARG2/C1QA/C1QC/MAP2K2/RAB17	2.8572547634061
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/120	157/9376	2.9859872611465	MT-CYB/COX4I1/MT-CO2/NDUFA10/NDUFA6/NDUFB7	2.8572547634061
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/120	75/9376	4.16711111111111	GSTA3/MGST3/GSTO1/GSTA4	3.13540536886137
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/120	205/9376	2.6679674796748	PLCG2/CD44/HLA-DPB1/GADD45G/PDIA3/CCND2/CCND1	2.74929125721299
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/120	77/9376	4.05887445887446	GADD45G/CCND1/HRAS/MAP2K2	3.06869326517947
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/120	43/9376	5.45116279069767	ECHS1/ECI1/ALDH7A1	3.33090050968296
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/120	79/9376	3.95611814345992	GSTA3/MGST3/GSTO1/GSTA4	3.00419767302447
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/120	122/9376	3.20218579234973	PLCG2/CCND1/HRAS/MAP2K2/ATP1B3	2.78762090297994
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/120	82/9376	3.81138211382114	GSTA3/MGST3/GSTO1/GSTA4	2.91132076415844
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/120	82/9376	3.81138211382114	HSPA1A/HLA-DPB1/PDIA3/CANX	2.91132076415844
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/120	47/9376	4.98723404255319	ACSS1/LDHB/ALDH7A1	3.12009415060604
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	7/120	224/9376	2.44166666666667	FDPS/HLA-DPB1/CCND2/CCND1/HRAS/CANX/MAP2K2	2.48653999327311
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/120	87/9376	3.59233716475096	MT-CYB/COX4I1/MT-CO2/ATP1B3	2.76586653207108
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/120	87/9376	3.59233716475096	GADD45G/CCND1/HRAS/MAP2K2	2.76586653207108
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/120	133/9376	2.93734335839599	GADD45G/CCND2/CCND1/HRAS/MAP2K2	2.56206728175779
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/120	54/9376	4.34074074074074	SMS/LDHB/SDSL	2.80317164996244
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/120	101/9376	3.09438943894389	PLCG2/PRKCZ/CCND1/HRAS	2.40949347893287
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/120	106/9376	2.94842767295597	HSP90B1/CCND1/HRAS/MAP2K2	2.29700501253089
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/120	157/9376	2.48832271762208	GADD45G/CCND2/CCND1/HRAS/MAP2K2	2.14126105318332
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/120	157/9376	2.48832271762208	DLG5/AMOT/PRKCZ/CCND2/CCND1	2.14126105318332
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/120	67/9376	3.49850746268657	ACSS1/LDHB/ALDH7A1	2.33685155524619
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	5/120	160/9376	2.44166666666667	ITGB1/NRCAM/HLA-DPB1/ITGB8/JAM3	2.09420023322512
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/120	68/9376	3.44705882352941	CCND1/HRAS/MAP2K2	2.30587237592019
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/120	69/9376	3.39710144927536	PLCG2/HRAS/MAP2K2	2.27546778392005
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/120	31/9376	5.04086021505376	ECHS1/ALDH7A1	2.56584022606644
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/120	71/9376	3.30140845070422	PLCG2/ATP6V0B/JAM3	2.21630372994107
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/120	71/9376	3.30140845070422	LDHB/HRAS/MAP2K2	2.21630372994107
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	8/120	333/9376	1.87707707707708	ITGB1/PRKCZ/ATP6V0B/CCND2/CCND1/HRAS/MAP2K2/ITGB8	1.8555309392477
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/120	170/9376	2.29803921568627	AMOT/ITGB1/PRKCZ/CCND1/JAM3	1.94464968231645
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/120	75/9376	3.12533333333333	TKT/ARG2/SDSL	2.10405676029962
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/120	75/9376	3.12533333333333	GADD45G/CCND2/CCND1	2.10405676029962
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/120	75/9376	3.12533333333333	HSP90B1/CANX/ATP1B3	2.10405676029962
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/120	125/9376	2.50026666666667	ORMDL1/PRKCZ/HRAS/MAP2K2	1.92262114501495
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/120	78/9376	3.00512820512821	ITGB1/C1QA/C1QC	2.02469338851368
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/120	79/9376	2.96708860759494	AP2S1/ATP6V0B/AP2A1	1.99908215124751
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/120	80/9376	2.93	PLCG2/HRAS/MAP2K2	1.97387130348194
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/120	39/9376	4.00683760683761	GCSH/ALDH7A1	2.14241295459072
NA	NA	hsa04517	IgSF CAM signaling	7/120	299/9376	1.82920847268673	PLCG2/NRP2/ITGB1/EPB41L3/NRCAM/MAP2K2/JAM3	1.65917710277432
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/120	136/9376	2.29803921568627	HSPA1A/CD46/CCND2/CCND1	1.73614450527972
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/120	86/9376	2.72558139534884	PLCG2/HRAS/MAP2K2	1.8303806104427
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/120	42/9376	3.72063492063492	ECHS1/ALDH7A1	2.01198900604964
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/120	42/9376	3.72063492063492	SAT1/GPX4	2.01198900604964
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/120	250/9376	1.8752	HSPA1A/AP2S1/PRKCZ/HRAS/CYTH3/AP2A1	1.59698806089455
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/120	139/9376	2.2484412470024	HSPA1A/HSP90B1/HRAS/MAP2K2	1.68839720819588
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/120	88/9376	2.66363636363636	CD46/C1QA/C1QC	1.78526719833466
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/120	140/9376	2.23238095238095	CCND1/HRAS/MAP2K2/TFAM	1.67275224427919
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/120	89/9376	2.63370786516854	CD44/ITGB1/ITGB8	1.76317844808402
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/120	44/9376	3.55151515151515	HMGB1/PNKP	1.93153113490998
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/120	44/9376	3.55151515151515	HSPD1/HLA-DPB1	1.93153113490998
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/120	91/9376	2.57582417582418	PLCG2/HRAS/MAP2K2	1.71989561561407
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/120	144/9376	2.17037037037037	C1QA/CCND1/ALDH7A1/C1QC	1.61146640074096
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/120	93/9376	2.52043010752688	ITGB1/GADD45G/CCND1	1.6777542522682
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/120	203/9376	1.92446633825944	ITGB1/CCND2/CCND1/HRAS/ITGB8	1.51617039637691
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/120	148/9376	2.11171171171171	GADD45G/CCND1/HRAS/MAP2K2	1.55215051716476
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/120	149/9376	2.09753914988814	PLCG2/HRAS/CYTH3/MAP2K2	1.53761456042435
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/120	48/9376	3.25555555555556	ECHS1/ALDH7A1	1.78379304675033
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/120	150/9376	2.08355555555556	GADD45G/CCND1/HRAS/MAP2K2	1.52319209027234
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/120	99/9376	2.36767676767677	CCND1/HRAS/MAP2K2	1.55762129858416
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/120	99/9376	2.36767676767677	HLA-DPB1/C1QA/C1QC	1.55762129858416
NA	NA	hsa04518	Integrin signaling	4/120	154/9376	2.02943722943723	ITGB1/CCND2/CCND1/ITGB8	1.46660195681879
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/120	100/9376	2.344	CD44/MME/HLA-DPB1	1.53845035725357
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/120	51/9376	3.0640522875817	PLCG2/ATP6V0B	1.68285210731975
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/120	12/9376	6.51111111111111	CD46	2.17502210858757
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/120	158/9376	1.97805907172996	GADD45G/CCND2/CCND1/CDKN1C	1.41169171349966
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/120	103/9376	2.27572815533981	COL14A1/MME/ATP1B3	1.48228328474778
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/120	56/9376	2.79047619047619	CCND2/CCND1	1.53009781781597
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/120	56/9376	2.79047619047619	HSPA1A/HSPD1	1.53009781781597
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/120	110/9376	2.13090909090909	PLCG2/LDHB/MAP2K2	1.3584463089431
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/120	112/9376	2.09285714285714	HSPA1A/ITGB1/HLA-DPB1	1.32476157108885
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/120	232/9376	1.68390804597701	ITGB1/IQGAP2/HRAS/MAP2K2/ITGB8	1.20098666449258
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/120	233/9376	1.67668097281831	FBN2/ITGB1/DCN/ATP1B3/ITGB8	1.19091880748501
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/120	60/9376	2.60444444444444	HRAS/MAP2K2	1.41954824562198
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/120	173/9376	1.80655105973025	FDPS/HLA-DPB1/PABPN1/MAP2K2	1.21914340860829
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/120	362/9376	1.51086556169429	HSP90B1/ITGB1/CCND2/CCND1/HRAS/MAP2K2/ITGB8	1.12866932983231
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/120	116/9376	2.02068965517241	PLCG2/ITGB1/JAM3	1.25945252862628
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/120	300/9376	1.56266666666667	HSPA1A/HSPB1/GADD45G/DUSP9/HRAS/MAP2K2	1.12779238948074
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/120	62/9376	2.52043010752688	HSPA1A/HRAS	1.36759900801329
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/120	63/9376	2.48042328042328	ECHS1/ALDH7A1	1.34238152836674
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/120	178/9376	1.75580524344569	NOTUM/CCND2/CCND1/RNF43	1.15914505634032
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/120	17/9376	4.59607843137255	NRP2	1.68967617545985
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/120	120/9376	1.95333333333333	PLCG2/HRAS/MAP2K2	1.19670833731128
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/120	243/9376	1.6076817558299	HSPA1A/SF3A2/CTNNBL1/DDX39B/SF1	1.09279121272135
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/120	65/9376	2.40410256410256	HRAS/MAP2K2	1.29336747610351
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/120	122/9376	1.92131147540984	PLCG2/HRAS/MAP2K2	1.16623544477027
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/120	66/9376	2.36767676767677	HSD17B1/COMT	1.26953648142487
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/120	18/9376	4.34074074074074	FUCA1	1.61529591125322
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/120	184/9376	1.69855072463768	PLCG2/ITGB1/PRKCZ/HRAS	1.08959835629601
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/120	67/9376	2.33233830845771	HRAS/MAP2K2	1.2461347003085
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	5/120	248/9376	1.5752688172043	HSP90B1/HRAS/CYTH3/MAP2K2/DYNC1H1	1.0453782173705
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/120	250/9376	1.56266666666667	MCOLN3/FUCA1/AP2S1/ATP6V0B/AP2A1	1.02670469484689
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/120	19/9376	4.11228070175439	GCSH	1.5461507441955
Organismal Systems	Immune system	hsa04611	Platelet activation	3/120	126/9376	1.86031746031746	PLCG2/ITGB1/PRKCZ	1.10697479270547
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/120	70/9376	2.23238095238095	HRAS/MAP2K2	1.17835747577455
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/120	70/9376	2.23238095238095	HLA-DPB1/CCND1	1.17835747577455
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/120	20/9376	3.90666666666667	DHCR24	1.48159570283513
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/120	130/9376	1.80307692307692	PRKCZ/HRAS/MAP2K2	1.04982392572292
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/120	323/9376	1.45139318885449	PLCG2/CD44/CCND2/CCND1/HRAS/MAP2K2	0.939992938104666
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/120	133/9376	1.76240601503759	PLCG2/HRAS/MAP2K2	1.00825467931529
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	4/120	196/9376	1.59455782312925	PLCG2/CCND1/HRAS/MAP2K2	0.957779155757539
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/120	22/9376	3.55151515151515	ALDH7A1	1.36419168311612
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/120	137/9376	1.71094890510949	GADD45G/HRAS/MAP2K2	0.954444716091477
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/120	201/9376	1.55489220563847	GADD45G/MLLT1/CCND2/PROM1	0.905457780621462
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/120	23/9376	3.39710144927536	ARG2	1.31050732746091
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/120	23/9376	3.39710144927536	FDPS	1.31050732746091
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/120	23/9376	3.39710144927536	MME	1.31050732746091
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/120	23/9376	3.39710144927536	ATP1B3	1.31050732746091
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/120	77/9376	2.02943722943723	GADD45G/CCND1	1.03274166212805
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/120	138/9376	1.69855072463768	PRKCZ/HRAS/MAP2K2	0.941267578746053
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/120	78/9376	2.0034188034188	HSPD1/BTG3	1.01320973491691
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/120	78/9376	2.0034188034188	ITGB1/HLA-DPB1	1.01320973491691
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/120	24/9376	3.25555555555556	GLCE	1.25971264405908
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/120	205/9376	1.52455284552846	CCND2/CCND1/HRAS/SND1	0.864614310369382
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/120	143/9376	1.63916083916084	HLA-DPB1/C1QA/C1QC	0.876942963026619
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/120	144/9376	1.62777777777778	DUSP9/HRAS/MAP2K2	0.864378338372127
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	4/120	212/9376	1.47421383647799	ITGB1/PRKCZ/HRAS/MAP2K2	0.795177714320446
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/120	214/9376	1.46043613707165	PLCG2/PDIA3/HRAS/MAP2K2	0.775792778903895
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/120	27/9376	2.89382716049383	ECHS1	1.12202938577832
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	4/120	216/9376	1.44691358024691	HSPA1A/HSPD1/HSP90B1/HRAS	0.756601640555764
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/120	86/9376	1.81705426356589	ITGB1/ITGB8	0.866676174037109
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/120	28/9376	2.79047619047619	ECHS1	1.08032096014442
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/120	154/9376	1.52207792207792	CCND1/HRAS/MAP2K2	0.743785517209193
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/120	89/9376	1.75580524344569	HRAS/MAP2K2	0.815702454890774
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/120	90/9376	1.7362962962963	HRAS/MAP2K2	0.799142299939428
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/120	156/9376	1.5025641025641	CCND1/HRAS/MAP2K2	0.720697293691242
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/120	31/9376	2.52043010752688	TKT	0.965433230350703
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/120	31/9376	2.52043010752688	ALDH7A1	0.965433230350703
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	4/120	227/9376	1.37679882525698	PDIA3/CCND1/HRAS/MAP2K2	0.654335138759477
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/120	93/9376	1.68028673835125	HRAS/MAP2K2	0.75067835238214
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/120	93/9376	1.68028673835125	ATP2B1/ATP1B3	0.75067835238214
Human Diseases	Immune disease	hsa05310	Asthma	1/120	32/9376	2.44166666666667	HLA-DPB1	0.930117936862081
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/120	94/9376	1.66241134751773	S100A9/HSP90B1	0.734912266988475
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/120	95/9376	1.64491228070175	ATP6V0B/HLA-DPB1	0.719332448813736
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/120	33/9376	2.36767676767677	VAMP3	0.896111093021287
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/120	34/9376	2.29803921568627	POLR2J3	0.863320251623829
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/120	166/9376	1.41204819277108	ATP2B1/MAP2K2/ATP1B3	0.609869382494852
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/120	98/9376	1.59455782312925	ATP2B1/ATP1B3	0.673665861758353
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/120	99/9376	1.57845117845118	HRAS/MAP2K2	0.658787146963957
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/120	99/9376	1.57845117845118	ITGB1/ITGB8	0.658787146963957
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	4/120	238/9376	1.31316526610644	PLCG2/RPS21/C1QA/C1QC	0.557187131149652
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/120	35/9376	2.23238095238095	ENOSF1	0.831662082994838
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/120	168/9376	1.3952380952381	CCND2/CCND1/HRAS	0.588566272500739
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/120	169/9376	1.38698224852071	HMGB1/HRAS/MAP2K2	0.578016069803098
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/120	36/9376	2.17037037037037	GALNT11	0.801061240787467
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/120	101/9376	1.54719471947195	HRAS/MAP2K2	0.629520987719933
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/120	102/9376	1.53202614379085	ATP2B1/ATP1B3	0.615126025999866
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/120	37/9376	2.11171171171171	COMT	0.771449396257974
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/120	103/9376	1.51715210355987	PABPN1/DDX39B	0.600885004826727
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/120	103/9376	1.51715210355987	C1QA/C1QC	0.600885004826727
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/120	103/9376	1.51715210355987	ARG2/HSPB1	0.600885004826727
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/120	104/9376	1.5025641025641	PISD/PCYT2	0.586794467825078
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/120	38/9376	2.05614035087719	ATP1B3	0.742764412157016
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/120	105/9376	1.48825396825397	PLCG2/GADD45G	0.572851070392567
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/120	105/9376	1.48825396825397	PLCG2/HRAS	0.572851070392567
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/120	105/9376	1.48825396825397	ITGB1/ITGB8	0.572851070392567
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/120	39/9376	2.0034188034188	HLA-DPB1	0.714949632941871
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/120	253/9376	1.23530961791831	PLCG2/CD44/ITGB1/CYTH3	0.432011880314293
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/120	109/9376	1.43363914373089	SLC27A2/PRKCZ	0.518485641486229
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/120	181/9376	1.29502762430939	HSPD1/ATP6V0B/HLA-DPB1	0.456342262289395
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/120	41/9376	1.90569105691057	GABRE	0.661727883184748
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/120	44/9376	1.77575757575758	TUSC3	0.587258872371681
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/120	44/9376	1.77575757575758	DYNC1H1	0.587258872371681
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/120	45/9376	1.7362962962963	HLA-DPB1	0.563714708117233
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/120	193/9376	1.21450777202073	PLCG2/PRKCZ/HRAS	0.342841970614703
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/120	47/9376	1.66241134751773	PRKCZ	0.518350753586987
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/120	195/9376	1.20205128205128	PLCG2/HMGB1/MAP2K2	0.324637369526875
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/120	48/9376	1.62777777777778	ATP1B3	0.496474419415732
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/120	122/9376	1.28087431693989	HRAS/MAP2K2	0.355542715665431
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/120	49/9376	1.59455782312925	GALNT11	0.475100773813802
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/120	50/9376	1.56266666666667	HLA-DPB1	0.454206214960975
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/120	52/9376	1.5025641025641	HSD17B1	0.413767706389804
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/120	52/9376	1.5025641025641	LRPAP1	0.413767706389804
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/120	54/9376	1.44691358024691	HLA-DPB1	0.374999311635774
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/120	56/9376	1.3952380952381	TUSC3	0.337760954464695
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/120	57/9376	1.37076023391813	ECHS1	0.31967634987
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/120	138/9376	1.13236714975845	ITGB1/MAP2K2	0.178359140094342
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/120	226/9376	1.03716814159292	ATP2B1/MAP2K2/ATP1B3	0.0643989976426499
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/120	63/9376	1.24021164021164	GPX4	0.217813157211759
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/120	63/9376	1.24021164021164	POLR2J3	0.217813157211759
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/120	63/9376	1.24021164021164	GADD45G	0.217813157211759
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/120	65/9376	1.20205128205128	ALDH7A1	0.186116430089402
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/120	66/9376	1.18383838383838	HLA-DPB1	0.170646705774983
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/120	154/9376	1.01471861471861	ATP2B1/ATP1B3	0.0209690775995959
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/120	238/9376	0.984873949579832	PLCG2/HRAS/MAP2K2	-0.0269124374616112
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/120	155/9376	1.00817204301075	CCND1/MAP2K2	0.0116807860704852
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/120	158/9376	0.989029535864979	HRAS/MAP2K2	-0.0158343332834302
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/120	73/9376	1.0703196347032	MLLT1	0.0686738054545959
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/120	163/9376	0.958691206543967	HRAS/MAP2K2	-0.0605759683254235
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/120	76/9376	1.0280701754386	SLC27A2	0.0279753183332917
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/120	76/9376	1.0280701754386	ATP1B3	0.0279753183332917
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/120	78/9376	1.0017094017094	PLCG2	0.00172608132013104
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/120	78/9376	1.0017094017094	ITGB1	0.00172608132013104
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/120	254/9376	0.922834645669291	PLCG2/MCOLN3/ATP2B1	-0.141957638893897
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/120	83/9376	0.94136546184739	SLC27A2	-0.061091272949456
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/120	86/9376	0.908527131782946	ATP1B3	-0.0970282623684809
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/120	180/9376	0.868148148148148	HLA-DPB1/PDIA3	-0.203370329990037
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/120	89/9376	0.877902621722846	GABRE	-0.131773538302474
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/120	90/9376	0.868148148148148	HRAS	-0.1431059651803
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/120	90/9376	0.868148148148148	ATP1B3	-0.1431059651803
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/120	91/9376	0.858608058608059	GABRE	-0.154318853469789
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/120	93/9376	0.840143369175627	HLA-DPB1	-0.176397547503917
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/120	98/9376	0.797278911564626	PLCG2	-0.229693852178477
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/120	98/9376	0.797278911564626	PLCG2	-0.229693852178477
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/120	99/9376	0.789225589225589	PLCG2	-0.24004700465625
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	2/120	200/9376	0.781333333333333	ITGB1/CYTH3	-0.355906130075396
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/120	105/9376	0.744126984126984	HRAS	-0.300206737800006
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/120	107/9376	0.730218068535825	LDHB	-0.319560355502159
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/120	108/9376	0.723456790123457	DDX39B	-0.329114072742245
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/120	109/9376	0.716819571865443	MAP2K2	-0.338587943593969
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/120	109/9376	0.716819571865443	HLA-DPB1	-0.338587943593969
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/120	110/9376	0.71030303030303	DCN	-0.347983566813934
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/120	115/9376	0.679420289855072	HRAS	-0.393840703225235
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/120	115/9376	0.679420289855072	HRAS	-0.393840703225235
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/120	115/9376	0.679420289855072	SLC34A2	-0.393840703225235
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/120	117/9376	0.667806267806268	BRD7	-0.411686770317561
Genetic Information Processing	Translation	hsa03010	Ribosome	2/120	222/9376	0.703903903903904	RPS21/MRPS21	-0.508356408601455
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/120	122/9376	0.640437158469945	CCND1	-0.455150013439405
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/120	133/9376	0.587468671679198	COMT	-0.545557923127208
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/120	134/9376	0.583084577114428	MAP2K2	-0.553454555583799
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/120	142/9376	0.550234741784038	PLCG2	-0.614893257615938
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/120	168/9376	0.465079365079365	HMGB1	-0.796573629850398
NA	NA	hsa04519	Cadherin signaling	3/120	404/9376	0.58019801980198	HRAS/GABRE/MAP2K2	-0.982098666062755
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/120	187/9376	0.417825311942959	TXNIP	-0.915597472002423
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/120	191/9376	0.409075043630017	HRAS	-0.93945076273899
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/120	194/9376	0.402749140893471	DYNC1H1	-0.957091792845959
NA	NA	hsa04082	Neuroactive ligand signaling	1/120	199/9376	0.392629815745394	GABRE	-0.986039310270686
NA	NA	hsa04382	Cornified envelope formation	1/120	217/9376	0.360061443932412	S100A9	-1.08594718209852
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/120	298/9376	0.262192393736018	IL1RL1	-1.47373962006242
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/120	370/9376	0.211171171171171	GABRE	-1.76271562051819